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FGF1 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF10 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF11 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF12 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF13 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF14 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF16 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF17 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF18 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF19 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF20 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF21 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF22 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF23 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF23 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF3 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF4 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF5 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF6 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF7 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF8 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF9 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24) is a synthetic peptide, shows anti-bacterial and anti-HBV activities. Brain Derived Basic Fibroblast Growth Factor (1-24) can be used in infection disease and immune disease research .
FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity .
hMSCs-Neu perchlorate (Compound 4) is a fluorescent probe that converts hMSCs into neurons in the presence of fibroblast growth factor (FGF). hMSCs-Neu perchlorate may have important applications in neuropathology and neurodegeneration research .
NSC 12 is an extracellular trap of fibroblast growth factor 2 (FGF2) that binds FGF2 and interferes with its interaction with FGFR1. NSC12 inhibits the proliferation of different FGF-dependent tumour cells both in vitro and in vivo with no systemic toxic effects .
Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis .
ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ERK activity with an IC50 of 5.0 μM .
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively . PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor .
Tec-IN-1 (Compound 21) is a Tec inhibitor (IC50s of 11.7 μM). Tec-IN-1 inhibits Tec-mediated tyrosine phosphorylation of FGF2, and inhibits FGF2 secretion from cells .
Synstatin (92-119) is an anti-tumor agent that inhibits angiogenesis and cancer cell invasion. Synstatin (92-119) down-regulates integrin α?β3 and reduces the activation of angiogenic growth factors VEGF and FGF-2 .
XRP44X inhibits Ras-induced transcription activation with the IC50 of 10 nM. XRP44X inhibits activation of the Ras-Erk-1/2 pathway by FGF-2 . XRP44X is an inhibitor of Ras/Erk activation of Elk3 that also affects microtubules .
AHR activator 1 is an aryl hydrocarbon receptor activator with activity regulating fibroblast growth factor-2 (FGF2)-induced branching morphogenesis. AHR activator 1 prevents the formation of cellular branches by inhibiting AHR signaling. AHR activator 1 also associates with adhesion of dissociated linkers, suggesting the importance of dissociated linkers in the inhibition of branching by AHR agonists. Studies of AHR activator 1 reveal its functional role in mammary gland morphogenesis and play a role in inhibiting FGF-induced invasion .
DG1 (Compound 8Nc) is a Thymidylate Synthase (TS) inhibitor that affects cancer angiogenesis and metabolic reprogramming in NSCLC cells. DG1 can effectively inhibit the expression of CD26, ET-1, FGF-1 and EGF. DG1 also effectively inhibits the proliferation of cancer tissue in the A549 xenograft mouse model .
AF3485 is a human mPGES-1 inhibitor that exhibits antitumor activity in vitro and in vivo. AF3485 inhibits tumor-associated angiogenesis by reducing PGE2 production, inhibiting EGFR signaling, and decreasing VEGF and FGF-2 expression. AF3485 reduced tumor growth in mice bearing human A431 xenograft tumors by subchronic administration.
Antitumor agent-177 (compound 57), a non-steroidal NSC12 derivative, shows potent FGF2 binding affinity with a Kd of 24 μM by SPR. Antitumor agent-177 significantly inhibits the formation of HSPG/FGF2/FGFR1 ternary complexes. Antitumor agent-177 inhibits FGFR activation and exerts a potent anti-tumor activity on multiple myeloma (MM) cell lines in vitro and in vivo .
NP603 is a potent inhibitor of FGF receptor 1, exhibiting remarkable activity against endothelial proliferation in HUVEC cells stimulated by rhFGF-2, with a minimum effective dose of 0.4 microM.
T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 µM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream) .
Bemarituzumab is a first-in-class, humanized IgG1 monoclonal antibody against FGFR2b (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has the potential for cancer research .
Antitumor agent-176 (Compound 22), an antitumor agent, can effectively bind to FGF2 and inhibit the activation of fibroblast growth factor receptor (FGFR) in multiple myeloma (MM) cells, exhibiting significant antitumor activity both in vivo and in vitro against MM .
Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection .
Surfen is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection .
CP-547632 is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 has antitumor efficacy .
CP-547632 hydrochloride is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 hydrochloride is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 hydrochloride has antitumor efficacy .
CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 TFA has antitumor efficacy .
Pueraria Extract is a kudzu extract, and its components include: Isoflavones. Pueraria Extract (ethanol extract) can significantly improve cardiac damage in rats with acute myocardial infarction. Pueraria Extract improves bile acid levels by increasing the expression of CYP7A1 and restoring the diversity of intestinal microbiota. Pueraria Extract can also inhibit the FXR-FGF15 signaling pathway and increase the expression of OST-α to increase bile acid reabsorption and fecal excretion. .
Ki 23057 is a competitive, orally active inhibitor for tyrosine kinase, which inhibits the phosphorylation of K-samII/FGF-R2, VEGF-R1, VEGF-R2, PDGF-Rβ and c-Kit, with IC50s of 88, 69, 83, 100 and 480 nM. Ki 23057 inhibits the proliferation of sclerogastric cancer cells OCUM-2MD3 and OCUM-8, and induces apoptosis. Ki 23057 exhibits antitumor efficacy in mouse models .
TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-κB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers .
3-Methylthienyl-carbonyl-JNJ-7706621 is a potent and selective inhibitor of cyclin-dependent kinase (CDK), with IC50s of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. 3-Methylthienyl-carbonyl-JNJ-7706621 also shows potent inhibition of GSK-3 (IC50=0.041 μM) and modest potency against CDK4, VEGF-R2, and FGF-R2 (IC50=0.11, 0.13, 0.22 μM, respectively). 3-Methylthienyl-carbonyl-JNJ-7706621 can be used for the research of cancer .
Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.
MCE Differentiation Inducing Compound Library contains a unique collection of 1,554 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.
hMSCs-Neu perchlorate (Compound 4) is a fluorescent probe that converts hMSCs into neurons in the presence of fibroblast growth factor (FGF). hMSCs-Neu perchlorate may have important applications in neuropathology and neurodegeneration research .
Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24) is a synthetic peptide, shows anti-bacterial and anti-HBV activities. Brain Derived Basic Fibroblast Growth Factor (1-24) can be used in infection disease and immune disease research .
Synstatin (92-119) is an anti-tumor agent that inhibits angiogenesis and cancer cell invasion. Synstatin (92-119) down-regulates integrin α?β3 and reduces the activation of angiogenic growth factors VEGF and FGF-2 .
FGF basic (93-110) (human, bovine) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
CXCL9(74-103) is a derivative peptide of CXCL9 that has a high affinity for glycosaminoglycans (GAGs) and can bind to GAGs. CXCL9(74-103) possesses anti-angiogenic properties, capable of reducing EGF, VEGF165, and FGF-2-mediated angiogenesis processes in vitro, without exhibiting cytotoxicity .
Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis .
Burosumab is a human fibroblast growth factor 23 (FGF23) neutralizing antibody that can be used for the research of X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia .
Bemarituzumab is a first-in-class, humanized IgG1 monoclonal antibody against FGFR2b (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has the potential for cancer research .
Burosumab is a human fibroblast growth factor 23 (FGF23) neutralizing antibody that can be used for the research of X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia .
Bemarituzumab is a first-in-class, humanized IgG1 monoclonal antibody against FGFR2b (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has the potential for cancer research .
FGF-18 Protein, Human is a heparin-binding polypeptide growth factor, involved in cartilage growth, maturation and the development of functional cartilage and bone tissue.
FGF-18 Protein, Rat is a heparin-binding polypeptide growth factor, involved in cartilage growth, maturation and the development of functional cartilage and bone tissue.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF-2 Protein, Rat, consists of 145 amino acids, produced by E.coli with tag free.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF-2 Protein, Mouse (145a.a), consists of 145 amino acids, produced by E.coli with tag free.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF basic/bFGF Protein, Human (146a.a), consists of 146 amino acids, produced by E.coli with tag free.
FGF-4 Protein, Human is a member of the FGF family that transforms 3T3 cells with high efficiency, stimulates endothelial cell proliferation, migration, and protease production, and shows angiogenic activity.
FGF-23 Protein, Human is a unique FGF subfamily member, acts as a hormone and requires α-Klotho to signal through canonical FGFR, and induces hypertrophy and mineralization during chondrogenesis.
FGF-17 Protein plays a crucial role in embryonic development, serving as a signaling molecule for brain induction and patterning. Its presence is vital for normal brain development, emphasizing its significance in shaping embryogenesis intricacies. FGF-17 interacts with FGFR3 and FGFR4, underscoring its involvement in signaling cascades that precisely orchestrate developmental events in the embryonic brain. FGF-17 Protein, Human (His) is the recombinant human-derived FGF-17 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FGF-17 Protein, Human (His) is 194 a.a., with molecular weight of ~25 kDa.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF basic/bFGF protein, Bovine, consists of 146 amino acids, produced by E.coli with tag free.
The FGF-1 protein plays a key role in regulating a variety of cellular processes, serving as a potent mitogen and ligand for FGFR1 and integrins. In the presence of heparin, FGF-1 binds to FGFR1, initiating dimerization and autophosphorylation, resulting in multiple signaling cascades. FGF-1 Protein, Mouse (N-His) is the recombinant mouse-derived FGF-1 protein, expressed by E. coli , with N-6*His, N-6*His labeled tag. The total length of FGF-1 Protein, Mouse (N-His) is 140 a.a., with molecular weight of ~17 kDa.
The FGF-1 protein is critical in cellular regulation, coordinating key processes such as cell survival, division, angiogenesis, differentiation and migration. It exhibits potent mitogenic properties in vitro and serves as a ligand for FGFR1 and integrins. FGF-1 Protein, Canine is the recombinant canine-derived FGF-1 protein, expressed by E. coli , with tag free. The total length of FGF-1 Protein, Canine is 140 a.a., with molecular weight of ~16 kDa.
Fibroblast growth factor 1 is a growth factor and signaling protein encoded by the FGF1 gene. FGF-1 is a ligand of FGFR1 and integrin, and plays an important role in cell survival, division, angiogenesis, differentiation, and migration. FGF-1 induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2, and AKT1, and also stimulates angiogenesis. FGF-1 Protein, Cynomolgus is the recombinant cynomolgus-derived FGF-1 protein, expressed by E. coli , with tag free.
FGF-15 Protein crucially suppresses bile acid biosynthesis by down-regulating CYP7A1 expression, contributing to intricate bile acid homeostasis control. Interacting with MALRD1 suggests potential involvement in molecular pathways beyond bile acid regulation. The molecular associations and regulatory functions underscore FGF-15's significance in maintaining physiological balance, particularly in bile acid metabolism. FGF-15 Protein, Mouse (His-SUMO) is the recombinant mouse-derived FGF-15 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of FGF-15 Protein, Mouse (His-SUMO) is 193 a.a., with molecular weight of ~38 kDa.
FGF-19 Protein, Human could activate a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.
FGF-21 Proteinas influences glucose uptake in adipocytes by inducing SLC2A1/GLUT1 expression, particularly with KLB's presence. It plays a crucial role in systemic glucose homeostasis and insulin sensitivity, interacting directly with KLB through its C-terminus and engaging with FGFR4. The protein's molecular mechanisms involve a complex interplay, emphasizing its broad impact beyond localized effects. FGF-21 Protein, Human (His) is the recombinant human-derived FGF-21 protein, expressed by E. coli , with N-6*His labeled tag.
FGF-19 protein plays a crucial role in regulating bile acid biosynthesis by inhibiting CYP7A1 expression through positive regulation of JNK and ERK1/2 cascades. It stimulates glucose uptake in adipocytes, dependent on KLB and FGFR4. FGF-19 Protein, Human (His) is the recombinant human-derived FGF-19 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FGF-19 Protein, Human (His) is 190 a.a., with molecular weight of ~26.0 kDa.
FGF-23 protein is a key regulator of phosphate homeostasis and inhibits renal tubular phosphate transport by reducing SLC34A1 levels. It also modulates vitamin D metabolism, negatively regulates osteoblast differentiation and matrix mineralization, and reduces parathyroid hormone secretion from the parathyroid glands. FGF-23 Protein, Rat (His) is the recombinant rat-derived FGF-23 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FGF-23 Protein, Rat (His) is 227 a.a., with molecular weight of ~29.5 kDa.
The FGF-17 Protein is crucial in regulating embryonic development, functioning as a signaling molecule for inducing and patterning the embryonic brain. It plays an essential role in normal brain development and interacts specifically with FGFR3 and FGFR4 receptors, pivotal in this developmental process. FGF-17 Protein, Mouse (His) is the recombinant mouse-derived FGF-17, expressed by E. coli , with C-6*His labeled tag. The total length of FGF-17 Protein, Mouse (His) is 194 a.a.,
FGF-19 Protein, Human could activate a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.
FGF-21 Proteinas, pivotal in promoting glucose uptake in adipocytes, induces SLC2A1/GLUT1 expression, not affecting SLC2A4/GLUT4, contingent on KLB.It significantly regulates systemic glucose homeostasis and insulin sensitivity, with direct KLB interaction via its C-terminus.Engagement with FGFR4 adds complexity to its molecular mechanisms, highlighting its role in orchestrating cellular responses beyond localized effects.FGF-21 Protein, Human (HEK293, mFc-Avi) is the recombinant human-derived FGF-21 protein, expressed by HEK293 , with N-mFc, N-Avi labeled tag.
FGF-22 Protein, multifaceted in physiological processes, influences fasting response, glucose homeostasis, lipolysis, and lipogenesis.It stimulates in vitro cell proliferation and may contribute to hair development.Functionally, FGF-22 forms complexes with FGFR1 and FGFR2, integral to FGF signaling pathways.Interactions with FGFBP1 highlight its role in finely tuned regulatory networks governing cellular and metabolic activities.FGF-22 Protein, Human (His-SUMO) is the recombinant human-derived FGF-22 protein, expressed by E.coli , with N-SUMO, N-6*His labeled tag.
FGF-21 is a metabolic regulator and a potential anti-diabetic agent. FGF-21 regulates energy balance and glucose and lipid homeostasis through a heterodimeric receptor complex comprising FGFR1 and 尾-klotho. FGF-21 can also signal through FGFR2 and FGFR3. FGF-21 can be used for research of obesity, NASH, NAFLD, and type 2 diabetes mellitus. FGF-21 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived FGF-21 protein, expressed by HEK293 , with C-6*His labeled tag.
FGF-21 Proteinas influences glucose uptake in adipocytes by inducing SLC2A1/GLUT1 expression, particularly with KLB's presence. It plays a crucial role in systemic glucose homeostasis and insulin sensitivity, interacting directly with KLB through its C-terminus and engaging with FGFR4. The protein's molecular mechanisms involve a complex interplay, emphasizing its broad impact beyond localized effects. FGF-21 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGF-21 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGF-21 Protein, Mouse (HEK293, His) is 182 a.a., with molecular weight of 20-29 kDa.
FGF-12, vital for nervous system development, positively regulates voltage-gated sodium channels, particularly SCN8A, enhancing neuronal excitability. It achieves this by elevating the voltage dependence of SCN8A fast inactivation. FGF-12 interacts specifically with the C-terminal region of SCN9A. FGF-12 Protein, Human is the recombinant human-derived FGF-12 protein, expressed by E. coli , with tag free. The total length of FGF-12 Protein, Human is 181 a.a., with molecular weight of 18-20 kDa.
FGF21 is a liver factor that signals through the FGF21 receptor in the paraventricular nucleus of the hypothalamus to regulate monosaccharide intake and preference for sweets. FGF21 promotes the progression of non-small cell lung cancer by activating the SIRT1/PI3K/AKT signaling pathway. FGF21 plays an important role in embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 Protein, Hamster (HEK293, His) is the recombinant FGF-21 protein, expressed by HEK293 , with C-His labeled tag.
FGF-12 forms complexes with signaling proteins regulates the cytoskeletal system, binds to FGF receptors, activates signaling cascades to prevent apoptosis and interacts with ribosome biogenetic complexes. FGF-12 has been linked to neurological diseases, cancer and heart disease, making it a potential target and therapeutic agent for gene therapy. FGF-12 Protein, Canine is the recombinant canine-derived FGF-12 protein, expressed by E. coli , with tag free.
FGF-17 Protein plays a crucial role in embryonic development, serving as a signaling molecule for brain induction and patterning. Its presence is vital for normal brain development, emphasizing its significance in shaping embryogenesis intricacies. FGF-17 interacts with FGFR3 and FGFR4, underscoring its involvement in signaling cascades that precisely orchestrate developmental events in the embryonic brain. FGF-17 Protein, Human (HEK293, His) is the recombinant human-derived FGF-17 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGF-17 Protein, Human (HEK293, His) is 194 a.a., with molecular weight of ~31 kDa.
FGF-21 Proteinas, pivotal in promoting glucose uptake in adipocytes, induces SLC2A1/GLUT1 expression, not affecting SLC2A4/GLUT4, contingent on KLB.It significantly regulates systemic glucose homeostasis and insulin sensitivity, with direct KLB interaction via its C-terminus.Engagement with FGFR4 adds complexity to its molecular mechanisms, highlighting its role in orchestrating cellular responses beyond localized effects.FGF-21 Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived FGF-21 protein, expressed by HEK293 , with N-Avi, N-mFc labeled tag.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF-2 Protein, Mouse (His), consists of 144 amino acids, produced by E.coli with N-His.
FGF-23 protein is an important regulator of phosphate homeostasis and inhibits renal tubular phosphate transport by reducing SLC34A1 levels. It upregulates EGR1 expression through KL, directly reduces PTH secretion, and negatively regulates osteoblast differentiation and matrix mineralization. FGF-23 Protein, Human (R179Q, HEK293, His) is the recombinant human-derived FGF-23 protein, expressed by HEK293 , with C-His labeled tag and R179Q, , , , mutation. The total length of FGF-23 Protein, Human (R179Q, HEK293, His) is 227 a.a., with molecular weight of 29-32 kDa.
FGF-21 Protein, Human (CHO, His) is a polypeptide chain containing the C-termimal His tag produced in CHO cells.FGF-21 Protein, Human (CHO, His) is a member of the fibroblast growth factor (FGF) subfamily, acts as a metabolic regulator with pleiotropic effects.
FGF-18 Protein intricately regulates cell proliferation, differentiation, and migration, crucial in normal ossification and bone development for skeletal maturation. It stimulates hepatic and intestinal proliferation, showcasing versatile functions. Interactions with FGFR3 and FGFR4 underscore FGF-18 Protein's significance in modulating intricate signaling pathways for fundamental tissue development and homeostasis. FGF-18 Protein, Human (HEK293, His) is the recombinant human-derived FGF-18 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FGF-18 Protein, Human (HEK293, His) is 180 a.a., with molecular weight of ~32 kDa.
The FGF-18 protein plays a key role in regulating cell proliferation, differentiation, and migration, particularly in normal ossification and bone development, showing its critical role in skeletal maturation. In addition, FGF-18 stimulates liver and intestinal proliferation, highlighting its multifunctional role in various tissues. FGF-18 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGF-18 protein, expressed by HEK293 , with C-His labeled tag.
FGF-16 Protein, Human (CHO) is a polypeptide chain containing 206 amino acids produced in CHO cells. FGF-16 is a heparin binding growth factor, a member of the FGF family.
FGF-9 is a member of mouse heparin-binding fibroblast growth factors located on the outside of cell membranes. FGF-9 is a regulator of chondrogenesis and vascularization during bone development. FGF-9 binds to fibroblast growth factor receptors (FGFRs) to activate downstream signaling pathways, such as PI3K-AKT, RAS-MAPK and protein kinase C (PKC) pathways. FGF-9 regulates embryonic development, cell proliferation, cell differentiation and cell migration. FGF-9 plays an important role in differentiation, survival of neuronal cells and growth stimulation of glial tumors. FGF-9 Protein, Mouse (N-His) is a recombinant protein with a N-His label that consisting of 208 amino acids and is produced in E. coli.
FGF2 Protein acts as a ligand for FGFR1-4 and an integrin ligand for FGF2 signaling. It regulates cell survival, division, differentiation, and migration. FGF2 Protein is a strong mitogen and can induce angiogenesis. FGF2 Protein, Chicken (His) is the recombinant FGF2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of FGF2 Protein, Chicken (His) is 146 a.a., with molecular weight of 27 kDa.
FGF-12 Protein, Human (177 a.a) is a single polypeptide chain with a molecular mass of 20.4 kDa. FGF12 can play a role in tissues by translocating into cells through the plasma membrane.
FGF-13 Protein, a microtubule-binding protein, directly binds and stabilizes tubulin, influencing microtubule polymerization. It negatively regulates axonal and leading process branching, crucial for neuron polarization and migration in the cerebral cortex and hippocampus. Additionally, FGF-13 regulates voltage-gated sodium channel transport and function, potentially impacting MAPK signaling. Interactions with SCN8A, SCN1A, SCN5A, SCN2A, and SCN11A suggest a role in modulating sodium channel activity and MAPK8IP2 scaffolding. FGF-13 Protein, Human is the recombinant human-derived FGF-13 protein, expressed by E. coli , with tag free. The total length of FGF-13 Protein, Human is 245 a.a., with molecular weight of ~27.6 kDa.
Fibroblast growth factor 14 is a bioactive protein found in the brain and pituitary gland that promotes fibroblast growth and is involved in embryonic development, angiogenesis, tissue repair and other processes. FGF-14 plays a neuroprotective role in in vitro Alzheimer's disease (AD) models by inhibiting MAPK signaling. FGF-14 Protein, Canine is the recombinant canine-derived FGF14 protein, expressed by E. coli , with tag free.
FGF2 protein is a multifunctional ligand that can bind to FGFR1, FGFR2, FGFR3 and FGFR4. It is also a key integrin ligand for FGF2 signal transduction and has an important interaction with the integrin ITGAV:ITGB3. FGF2 plays a critical role in cell survival, division, differentiation, and migration, serves as a potent mitogen, and induces angiogenesis. FFGF basic/bFGF protein, Bovine (His)) is the recombinant bovine-derived FGF2 protein, expressed by E. coli , with N-6*His labeled tag.
FGF-2 protein is a member of the fibroblast growth factor family, involved in biological processes such as bone healing, cartilage repair, tumor development, and nerve regeneration. FGF-2 is also a mitogen that accelerates cell proliferation. It regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. FGF-2 protein, Mouse (154 a.a.), is a recombinant protein produced in E. coli (Escherichia coli), consisting of 154 amino acids (M1-S154), and is untagged.
FGF-17 Protein plays a crucial role in embryonic development, serving as a signaling molecule for brain induction and patterning. Its presence is vital for normal brain development, emphasizing its significance in shaping embryogenesis intricacies. FGF-17 interacts with FGFR3 and FGFR4, underscoring its involvement in signaling cascades that precisely orchestrate developmental events in the embryonic brain. FGF-17 Protein, Human is the recombinant human-derived FGF-17 protein, expressed by E. coli , with tag free.
The FGF-4 protein plays a key role in embryonic development and is central to cell proliferation and differentiation. It is essential for the survival of mouse embryos after implantation and is key to normal limb and heart valve development. FGF-4 Protein, Mouse is the recombinant mouse-derived FGF-4 protein, expressed by E. coli , with tag free.
FGF-23 protein is a key regulator of phosphate homeostasis and inhibits renal tubular phosphate transport by reducing SLC34A1 levels. It also modulates vitamin D metabolism, negatively regulates osteoblast differentiation and matrix mineralization, and reduces parathyroid hormone secretion from the parathyroid glands. FGF-23 Protein, Rat (P. pastoris, His) is the recombinant rat-derived FGF-23 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of FGF-23 Protein, Rat (P. pastoris, His) is 227 a.a., with molecular weight of 27.5 kDa.
FGF-21 Protein, Human (181a.a), Human is an atypical member of the fibroblast growth factor (FGF) subfamily, acts as a metabolic regulator with pleiotropic effects.
FGF2 Protein acts as a ligand for FGFR1-4 and an integrin ligand for FGF2 signaling. It regulates cell survival, division, differentiation, and migration. FGF2 Protein is a strong mitogen and can induce angiogenesis. FGF2 Protein, Chicken (N-His, C-Myc) is the recombinant FGF2 protein, expressed by E. coli, with C-Myc, N-10*His labeled tag. The total length of FGF2 Protein, Chicken (N-His, C-Myc) is 146 a.a., with molecular weight of 23.8 kDa.
FGF-12, vital for nervous system development, positively regulates voltage-gated sodium channels, particularly SCN8A, enhancing neuronal excitability. It achieves this by elevating the voltage dependence of SCN8A fast inactivation. FGF-12 interacts specifically with the C-terminal region of SCN9A. FGF-12 Protein, Human (181a.a, His) is the recombinant human-derived FGF-12 protein, expressed by E. coli , with N-6*His labeled tag. The total length of FGF-12 Protein, Human (181a.a, His) is 181 a.a., with molecular weight of ~23 kDa.
FGF2 protein is a multifunctional ligand that can bind to FGFR1, FGFR2, FGFR3 and FGFR4. It is also a key integrin ligand for FGF2 signal transduction and has an important interaction with the integrin ITGAV:ITGB3. FGF2 plays a critical role in cell survival, division, differentiation, and migration, serves as a potent mitogen, and induces angiogenesis. FGF basic/bFGF protein, Bovine (P. pastoris, N-His) is the recombinant bovine-derived FGF2 protein, expressed by P. pastoris , with N-6*His labeled tag.
FGF basic, or bFGF (fibroblast growth factor basic), initiates at an alternative CUG codon, marking a distinctive feature in translational initiation. This alternative start codon plays a pivotal role in regulating the expression and functional properties of FGF basic. FGF basic/bFGF Protein, Human (P. pastoris, N-His) is the recombinant human-derived FGF basic/bFGF protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of FGF basic/bFGF Protein, Human (P. pastoris, N-His) is 146 a.a., with molecular weight of 17.9 kDa.
FGF-14 Protein likely plays a crucial role in the development and functioning of the nervous system, contributing to intricate processes underlying neural structure and activity. Its interaction with SCN8A suggests potential involvement in modulating this sodium channel's activity, emphasizing its intricate role in neurophysiology. FGF-14 Protein, Human (isoform 1B) is the recombinant human-derived FGF-14 protein, expressed by E. coli , with tag free.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF basic/bFGF Protein, Human (145a.a), consists of 145 amino acids, produced by E.coli with tag free.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF basic/bFGF Protein, Human (154a.a), consists of 154 amino acids, produced by E.coli with tag free.
Activin AB protein is a member of the transforming growth factor-β (TGF-β) superfamily and plays a key role in various biological processes such as cell differentiation, proliferation, and apoptosis. It is involved in embryonic development, tissue repair and immune regulation. FGF-9 Protein, Human (HEK293, Fc, solution) is the recombinant human-derived FGF-9 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of FGF-9 Protein, Human (HEK293, Fc, solution) is 205 a.a., with molecular weight of ~54 & 37 kDa, respectively.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF basic/bFGF Protein, Human (154a.a, His), consists of 154 amino acids, produced by E.coli with tag free.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF basic/bFGF Protein, Human (145a.a, His), consists of 145 amino acids, produced by E.coli with tag free.
Activin AB protein is a member of the transforming growth factor-β (TGF-β) superfamily and plays a key role in various biological processes such as cell differentiation, proliferation, and apoptosis. It is involved in embryonic development, tissue repair and immune regulation. FGF-9 Protein, Human (HEK293, N-hFc) is the recombinant human-derived FGF-9 protein, expressed by HEK293 , with N-hFc labeled tag.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF basic/bFGF Protein, Human (157a.a), consists of 157 amino acids, produced by E.coli with tag free.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF basic/bFGF Protein, Human (K128N, solution), consists of 155 amino acids, produced by E.coli with tag free.
FGF-1 protein complexly regulates cell survival, division, angiogenesis, differentiation, and migration. As a potent mitogen, it acts as a ligand for FGFR1 and integrins. FGF-1 Protein, Human (154a.a) is the recombinant human-derived FGF-1 protein, expressed by E. coli , with tag free.
The FGF-5 protein critically regulates cell proliferation and differentiation, particularly during the hair growth cycle. It plays a key role in normal hair follicle progression, inhibiting hair elongation by promoting the anagen to catagen transition. FGF-5 Protein, Human (GST) is the recombinant human-derived FGF-5 protein, expressed by E. coli , with N-GST labeled tag.
FGF-8b Protein, Human/Mouse is the recombinant mouse, human-derived FGF-8b protein, expressed by E. coli , with tag free. The total length of FGF-8b Protein, Human/Mouse is 193 a.a., with molecular weight of 21-24 kDa.
The FGF-4 protein coordinates embryonic development, cell proliferation and differentiation and is critical for normal limb and heart valve development. FGF-4 may promote embryonic molar tooth bud development by inducing key gene expression. FGF-4 Protein, Human (153a.a) is the recombinant human-derived FGF-4 protein, expressed by E. coli , with tag free.
The FGF-4 protein coordinates embryonic development, cell proliferation and differentiation and is critical for normal limb and heart valve development. FGF-4 may promote embryonic molar tooth bud development by inducing key gene expression. FGF-4 Protein, Human (136a.a) is the recombinant human-derived FGF-4 protein, expressed by E. coli , with tag free.
FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 alpha (IIIc) Protein, Human (HEK293, His-Avi) is 353 a.a., with molecular weight of 65-85 kDa.
FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha Protein, Human (Biotinylated, sf9, Flag, Avi) is the recombinant human-derived FGFR-1 alpha, expressed by Sf9 insect cells , with Avi, Flag labeled tag. The total length of FGFR-1 alpha Protein, Human (Biotinylated, sf9, Flag, Avi) is 425 a.a.,
FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is 353 a.a., with molecular weight of 68-80 kDa.
The FGFBP3 protein is a heparin-binding protein that complexly regulates fibroblast growth factor 2 (FGF2) dynamics. By forming a binding complex with FGF2, it blocks heparin binding of FGF2 and may limit its anchoring to extracellular matrix glycosaminoglycans. FGFBP3 Protein, Human (sf9, His) is the recombinant human-derived FGFBP3 protein, expressed by Sf9 insect cells , with C-His labeled tag.
The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIc) Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 beta IIIc protein, expressed by HEK293 , with C-hFc labeled tag.
FGFR-1 alpha, a conserved member of the FGFR family, binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation. Mutations in FGFR1 cause syndromes and disorders. It exhibits ubiquitous expression, with notable levels in ovary (RPKM 21.8), fat (RPKM 21.4), and 25 other tissues. Alternatively spliced variants contribute to its functional diversity. FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 alpha, expressed by HEK293 , with C-hFc labeled tag. FGFR-1 alpha (IIIb) Protein, Human (HEK293, Fc), has molecular weight of ~113.3 kDa.
FGFR-1 alpha, a conserved member of the FGFR family, binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation. Mutations in FGFR1 cause syndromes and disorders. It exhibits ubiquitous expression, with notable levels in ovary (RPKM 21.8), fat (RPKM 21.4), and 25 other tissues. Alternatively spliced variants contribute to its functional diversity. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 alpha, expressed by HEK293 , with C-His, C-10*His labeled tag. FGFR-1 alpha (IIIb) Protein, Human (HEK293, His), has molecular weight of 60-90 kDa.
FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293 , with C-hFc labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc), has molecular weight of 76-106 kDa.
FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293 , with C-His labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, His), has molecular weight of 45-60 kDa.
FGFR-3 alpha (IIIb) Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFR-3 alpha, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-3 alpha (IIIb) Protein, Mouse (HEK293, His) is 328 a.a., with molecular weight of 53-70 kDa.
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIb) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIb) Protein, Human (HEK293, His-Avi) is 355 a.a., with molecular weight of 65-75 kDa.
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIb) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 beta (IIIb) Protein, Human (HEK293, His-Avi) is 249 a.a., with molecular weight of 40-55 kDa.
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag.
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag.
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is 355 a.a., with molecular weight of 65-75 kDa.
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is 249 a.a., with molecular weight of 40-55 kDa.
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 alpha IIIc protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta IIIc protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-hFc labeled tag.
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 beta (IIIb) Protein, Human (HEK293, His) is the recombinant human-derived FGFR-2 beta IIIb protein, expressed by HEK293 , with C-6*His labeled tag.
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 alpha IIIb protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-2 alpha IIIc protein, expressed by HEK293 , with C-His, C-Avi labeled tag.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.Animal-Free FGF-2 Protein, Mouse (His), consists of 144 amino acids, produced by E.coli with tag free.
FGF-1 protein complexly regulates cell survival, division, angiogenesis, differentiation, and migration. As a potent mitogen, it acts as a ligand for FGFR1 and integrins. Animal-Free FGF-1 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-1 protein, expressed by E. coli , with C-His labeled tag.
FGF-18 Protein intricately regulates cell proliferation, differentiation, and migration, crucial in normal ossification and bone development for skeletal maturation. It stimulates hepatic and intestinal proliferation, showcasing versatile functions. Interactions with FGFR3 and FGFR4 underscore FGF-18 Protein's significance in modulating intricate signaling pathways for fundamental tissue development and homeostasis. Animal-Free FGF-18 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-18 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-18 Protein, Human (His) is 173 a.a., with molecular weight of ~21.11 kDa.
FGF-21 Proteinas, pivotal in promoting glucose uptake in adipocytes, induces SLC2A1/GLUT1 expression, not affecting SLC2A4/GLUT4, contingent on KLB.It significantly regulates systemic glucose homeostasis and insulin sensitivity, with direct KLB interaction via its C-terminus.Engagement with FGFR4 adds complexity to its molecular mechanisms, highlighting its role in orchestrating cellular responses beyond localized effects.Animal-Free FGF-21 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-21 protein, expressed by E.coli , with C-His labeled tag.
FGF-16 Protein orchestrates embryonic development, regulating cell proliferation and differentiation. Its vital role in cardiomyocyte proliferation and heart development becomes evident through intricate interactions with FGFR1 and FGFR2. Forming essential molecular connections, FGF-16 contributes to signaling pathways crucial for embryonic development and cellular processes. Animal-Free FGF-16 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-16 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-16 Protein, Human (His) is 207 a.a., with molecular weight of ~24.57 kDa.
FGF-19 protein plays a crucial role in regulating bile acid biosynthesis by inhibiting CYP7A1 expression through positive regulation of JNK and ERK1/2 cascades. It stimulates glucose uptake in adipocytes, dependent on KLB and FGFR4. Animal-Free FGF-19 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-19 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-19 Protein, Human (His) is 194 a.a., with molecular weight of ~22.62 kDa.
FGF-17 Protein plays a crucial role in embryonic development, serving as a signaling molecule for brain induction and patterning. Its presence is vital for normal brain development, emphasizing its significance in shaping embryogenesis intricacies. FGF-17 interacts with FGFR3 and FGFR4, underscoring its involvement in signaling cascades that precisely orchestrate developmental events in the embryonic brain. Animal-Free FGF-17 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-17 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free FGF-17 Protein, Human (His) is 194 a.a., with molecular weight of ~23.32 kDa.
FGF-22 Protein, multifaceted in physiological processes, influences fasting response, glucose homeostasis, lipolysis, and lipogenesis.It stimulates in vitro cell proliferation and may contribute to hair development.Functionally, FGF-22 forms complexes with FGFR1 and FGFR2, integral to FGF signaling pathways.Interactions with FGFBP1 highlight its role in finely tuned regulatory networks governing cellular and metabolic activities.Animal-Free FGF-22 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-22 protein, expressed by E.coli , with N-SUMO, N-His labeled tag.
KGF/FGF-7 proteins coordinate embryonic development and regulate basic processes such as cell proliferation and differentiation. Its critical role extends to normal branching morphogenesis. KGF/FGF-7 Protein, Human (His) is the recombinant human-derived KGF/FGF-7 protein, expressed by E. coli , with N-His labeled tag.
FGF-12, vital for nervous system development, positively regulates voltage-gated sodium channels, particularly SCN8A, enhancing neuronal excitability. It achieves this by elevating the voltage dependence of SCN8A fast inactivation. FGF-12 interacts specifically with the C-terminal region of SCN9A. Animal-Free FGF-12 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-12 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-12 Protein, Human (His) is 181 a.a., with molecular weight of ~21.23 kDa.
KGF-2/FGF-10 Protein, Mouse is a paracrine signaling molecule and is involved in the branching of morphogenesis in multiple organs such as the lungs, skin, ear and salivary glands.
KGF-2/FGF-10 proteins coordinate embryonic development, regulate cell proliferation and differentiation, and are indispensable in branching morphogenesis. This multifunctional protein may aid in wound healing. KGF-2/FGF-10 Protein, Human (Biotinylated, Primary Amine Labeling) is the recombinant human-derived KGF-2/FGF-10 protein, expressed by E. coli , with tag free. The total length of KGF-2/FGF-10 Protein, Human (Biotinylated, Primary Amine Labeling) is 171 a.a., with molecular weight of ~19.3 kDa.
Animal-Free FGF-8a Protein, Human (His) is the recombinant human-derived animal-FreeFGF-8a protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-8a Protein, Human (His) is 182 a.a., with molecular weight of ~22.14 kDa.
FGF-20 protein, a homodimer, functions as a neurotrophic factor essential for regulating central nervous system development and function.It interacts with specific receptors, FGFR2 and FGFR4, with heparan sulfate glycosaminoglycans enhancing the binding affinity between fibroblast growth factors (FGFs) and their receptors, serving as coreceptors in this intricate signaling process.Animal-Free FGF-20 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-20 protein, expressed by E.coli , with C-His labeled tag.
FGF-23 protein is an important regulator of phosphate homeostasis and inhibits renal tubular phosphate transport by reducing SLC34A1 levels. It upregulates EGR1 expression through KL, directly reduces PTH secretion, and negatively regulates osteoblast differentiation and matrix mineralization. Animal-Free FGF-23 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-23 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-23 Protein, Human (His) is 227 a.a., with molecular weight of ~26.27 kDa.
The FGF-6 protein coordinates cell proliferation, differentiation, angiogenesis, and myogenesis and is critical for normal muscle regeneration. It interacts with FGFR1, FGFR2, and FGFR4 to mediate signaling cascades that affect various cellular processes. Animal-Free FGF-6 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-6 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-6 Protein, Human (His) is 168 a.a., with molecular weight of ~19.66 kDa.
KGF-2/FGF-10 Protein, Human (169a.a) is a heparin-binding protein that binds to FGF2 IIIb and FGFR1III-b receptors, promotes the growth, proliferation, and differentiation of epithelial cells and can enhance corneal wound healing.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.GMP FGF basic/bFGF Protein, Human, consists of 157 amino acids, produced by E.coli with tag free.
FGF-13 protein is a microtubule-binding protein that directly binds and stabilizes tubulin and affects microtubule polymerization. It exerts negative regulation on axonal and leading process branches, which are critical for neuronal polarization and migration in the cerebral cortex and hippocampus. Animal-Free FGF-13 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-13 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-13 Protein, Human (His) is 245 a.a., with molecular weight of ~21.23 kDa.
FGF-14 Protein likely plays a crucial role in the development and functioning of the nervous system, contributing to intricate processes underlying neural structure and activity. Its interaction with SCN8A suggests potential involvement in modulating this sodium channel's activity, emphasizing its intricate role in neurophysiology. Animal-Free FGF-14 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-14 protein, expressed by E. coli , with N-His labeled tag.
KGF/FGF-7 proteins coordinate embryonic development and regulate basic processes such as cell proliferation and differentiation. Its critical role extends to normal branching morphogenesis. KGF/FGF-7 Protein, Human is the recombinant human-derived KGF/FGF-7 protein, expressed by E. coli , with tag free.
The FGF-9 protein plays a key role in embryonic development, controlling cell proliferation, differentiation, and migration. Its diverse functions include glial cell growth and differentiation, gliosis in brain repair, neuronal cell differentiation and survival, and promotion of glioma growth. Animal-Free FGF-9 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-9 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-9 Protein, Human (His) is 208 a.a., with molecular weight of ~22.14 kDa.
KGF/FGF-7 proteins coordinate embryonic development and regulate basic processes such as cell proliferation and differentiation. Its critical role extends to normal branching morphogenesis. GMP KGF/FGF-7 Protein, Human is the recombinant human-derived KGF/FGF-7 protein, expressed by E. coli , with tag free.
KGF/FGF-7 proteins coordinate embryonic development and regulate basic processes such as cell proliferation and differentiation. Its critical role extends to normal branching morphogenesis. KGF/FGF-7 Protein, Human (HEK293, His) is the recombinant human-derived KGF/FGF-7 protein, expressed by HEK293 , with C-6*His labeled tag.
KGF/FGF-7 Protein, Human (CHO) is a polypeptide mitogen that belongs to the family of fibroblast growth factors, binds only to a splice variant of FGFR2 (FGFR2 IIIb) and is a highly specific paracrine growth factor for epithelial cells. KGF/FGF-7 Protein and its receptor are important for normal wound healing.
KGF-2/FGF-10 proteins coordinate embryonic development, regulate cell proliferation and differentiation, and are indispensable in branching morphogenesis. This multifunctional protein may aid in wound healing. Animal-Free KGF-2/FGF-10 Protein, Human (His) is the recombinant human-derived animal-FreeKGF-2/FGF-10 protein, expressed by E. coli , with C-His, C-His labeled tag. The total length of Animal-Free KGF-2/FGF-10 Protein, Human (His) is 169 a.a., with molecular weight of ~20.06 kDa.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.Animal-Free FGF-2 Protein, Pig (His), consists of 1 amino acids, produced by E.coli with tag free.
FGF basic, or bFGF (fibroblast growth factor basic), initiates at an alternative CUG codon, marking a distinctive feature in translational initiation. This alternative start codon plays a pivotal role in regulating the expression and functional properties of FGF basic.Heat Stable FGF basic/bFGF Protein, Human, Human is the recombinant human-derived Heat Stable FGF-basic protein, expressed by E. coli , with tag free.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.Animal-Free FGF basic/bFGF Protein, Human (154a.a), consists of 154 amino acids, produced by E.coli with tag free.
FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.Animal-Free FGF basic/bFGF Protein, Human (154a.a, His), consists of 154 amino acids, produced by E.coli with tag free.
Animal-Free FGF-5 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-5 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-5 Protein, Human (His) is 241 a.a., with molecular weight of ~28.46 kDa.
The FGF-4 protein coordinates embryonic development, cell proliferation and differentiation and is critical for normal limb and heart valve development. FGF-4 may promote embryonic molar tooth bud development by inducing key gene expression. Animal-Free FGF-4 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-4 protein, expressed by E. coli , with C-His labeled tag.
FGF-3 Protein orchestrates embryonic development, cell proliferation, and differentiation, crucial for normal ear development and tissue morphogenesis. Interactions with FGFR1 and FGFR2, along with heparan sulfate glycosaminoglycans, underpin FGF-3's diverse functions. The potentiated binding affinity emphasizes the multifaceted nature of FGF-3 in shaping essential developmental processes through intricate molecular interactions. Animal-Free FGF-3 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-3 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-3 Protein, Human (His) is 185 a.a., with molecular weight of ~21.99 kDa.
Animal-Free FGF-8b Protein, Human/Mouse (His) is the recombinant human-derived animal-FreeFGF-8b protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-8b Protein, Human (His) is 183 a.a., with molecular weight of ~22.14 kDa.
FIBP is an intracellular chaperone of acidic fibroblast growth factor (aFGF) and mediates the mitogenic effects of aFGF, affecting cell types through mitosis and inducing morphological changes and differentiation. This gene expresses two isoforms, showing potential functional diversity. FIBP Protein, Human is the recombinant human-derived FIBP protein, expressed by E. coli , with tag free. The total length of FIBP Protein, Human is 357 a.a., with molecular weight of 40-50 kDa.
KGF-2/FGF-10 Protein orchestrates embryonic development, regulating cell proliferation and differentiation, with indispensable significance in branching morphogenesis. This versatile protein potentially contributes to wound healing. Engaging with FGFR1 and FGFR2, it forms molecular complexes, highlighting its multifaceted functions. Interactions with FGFBP1 emphasize its intricate network in orchestrating cellular responses and developmental events during embryogenesis. KGF-2/FGF-10 Protein, Human (N-His) is the recombinant human-derived KGF-2/FGF-10 protein, expressed by E. coli, with N-His labeled tag. The total length of KGF-2/FGF-10 Protein, Human (N-His) is 169 a.a., with molecular weight of 21-23 kDa.
The FGF-11 isoform 1 protein is thought to play an important role in the development and function of the nervous system. Its presence indicates involvement in complex processes responsible for establishing and maintaining neural structure and activity. Animal-Free FGF-11 isoform 1 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-11 isoform 1 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-11 isoform 1 Protein, Human (His) is 225 a.a., with molecular weight of ~25.81 kDa.
FGF-11 isoform 2 protein is a member of the fibroblast growth factor family, characterized by broad mitotic and cell survival activities, affecting embryonic development, cell growth, morphogenesis, tissue repair, and tumor growth. Its specific function has not yet been determined, but the expression pattern of its mouse homolog suggests a role in nervous system development. Animal-Free FGF-11 isoform 2 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-11 isoform 2 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-11 isoform 2 Protein, Human (His) is 166 a.a., with molecular weight of ~19.34 kDa.
FGF19 Antibody (YA2672) is a biotin-conjugated non-conjugated IgG antibody, targeting FGF19, with a predicted molecular weight of 24 kDa (observed band size: 36 kDa). FGF19 Antibody (YA2672) can be used for WB experiment in human background.
FGF2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 31 kDa, targeting to FGF2. It can be used for WB assays with tag free, in the background of Human.
FGF21 Antibody (YA3276) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3276), targeting FGF21, with a predicted molecular weight of 22 kDa. FGF21 Antibody (YA3276) can be used for WB, IHC-P experiment in human, mouse, rat background.
FGF1 Antibody (YA1430) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1430), targeting FGF1, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). FGF1 Antibody (YA1430) can be used for WB, IHC-P experiment in human, mouse, rat background.
KGF Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 23 kDa, targeting to KGF. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.
CD266 antigen; FGF inducible 14; Fibroblast growth factor inducible immediate early response protein 14; FN14; TNFRSF 12A; Tweak receptor; TweakR
WB, IHC-P, IP
Human, Mouse, Rat
CD266 Antibody (YA2676) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2676), targeting CD266, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). CD266 Antibody (YA2676) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.
FGF1 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF10 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF11 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF12 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF13 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF14 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF16 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF17 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF18 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF19 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF20 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF21 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF22 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF23 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF23 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF3 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF4 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF5 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF6 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF7 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF8 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
FGF9 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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