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Results for "

caspases 3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (180) 5-HT Receptor (1) Akt (15) AMPK (1) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (4) Antibiotic (4) Apoptosis (179) Arenavirus (2) Aurora Kinase (1) Autophagy (11) Bacterial (8) Bcl-2 Family (46) Beta-secretase (2) Biochemical Assay Reagents (3) c-Myc (1) Calcium Channel (9) CaMK (2) Cannabinoid Receptor (1) Casein Kinase (1) Cathepsin (1) CDK (9) CFTR (2) Cholinesterase (ChE) (2) Constitutive Androstane Receptor (1) COX (4) Cytochrome P450 (3) DNA/RNA Synthesis (3) DYRK (1) EGFR (1) Endogenous Metabolite (15) Epigenetic Reader Domain (1) ERK (12) Fat Mass and Obesity-associated Protein (FTO) (1) Ferroptosis (3) FGFR (1) Flavivirus (3) FLT3 (3) Fluorescent Dye (11) Formyl Peptide Receptor (FPR) (1) Fungal (2) Glutaminase (3) GSK-3 (2) HDAC (8) Histone Methyltransferase (1) HIV (1) HIV Protease (1) HSP (3) IAP (2) IGF-1R (1) iGluR (4) IKK (1) Integrin (4) Interleukin Related (6) Isotope-Labeled Compounds (7) JAK (3) JNK (5) Keap1-Nrf2 (3) Lipoxygenase (1) MAP3K (1) MDM-2/p53 (9) mGluR (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (3) MMP (1) mTOR (4) MyD88 (1) Na+/K+ ATPase (1) Necroptosis (2) NF-κB (8) NO Synthase (1) Orexin Receptor (OX Receptor) (2) P-glycoprotein (2) p38 MAPK (7) Parasite (6) PARP (27) PERK (1) PGE synthase (1) Phosphatase (2) Phospholipase (1) PI3K (5) Pim (1) PKC (4) Polo-like Kinase (PLK) (1) Potassium Channel (3) PPAR (2) PROTACs (1) Protease Activated Receptor (PAR) (1) Pyroptosis (6) RABV (1) RAD51 (2) RAR/RXR (1) Reactive Oxygen Species (21) ROCK (1) ROS Kinase (2) SARS-CoV (1) Ser/Thr Protease (2) Sirtuin (1) SOD (1) Sodium Channel (1) STAT (6) Succinate Dehydrogenase (1) TGF-β Receptor (1) TNF Receptor (1) Topoisomerase (1) TRP Channel (4) VDAC (2) VEGFR (2) Virus Protease (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (195) Cardiovascular Disease (12) Endocrinology (6) Infection (26) Inflammation/Immunology (36) Metabolic Disease (12) Neurological Disease (43)
Oligonucleotides:	Nucleosides and their Analogs (1)

284

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136975

Caspase-3-IN-1	Caspase	Neurological Disease Metabolic Disease
Caspase-3-IN-1 (compound 11b) is a potent *Caspase-3* inhibitor, with an IC₅₀ of 14.5 nM .

HY-P1095

Ivachtin Caspase-3 Inhibitor VII	Caspase	Cardiovascular Disease Neurological Disease
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl *caspase-3* inhibitor with an IC₅₀ of 23 nM. Ivachtin has modest selectivity for the remaining caspases .

HY-121320

Raptinal 5 Publications Verification	Caspase Apoptosis	Cancer
Raptinal, a agent that directly activates *caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase*-9 .

HY-N10091

2,3-Dihydro-3α-methoxynimbolide	Apoptosis	Others
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521 .

HY-161991

Caspase-3 activator 4	Caspase Apoptosis	Cancer
Caspase-3 activator 4 (compound 4o) is a potent and cross the blood-brain barrier *caspase-3* activator. Caspase-3 activator 4 shows antiproliferative activity. Caspase-3 activator 4 induces apoptosis. Caspase-3 activator 4 increases the gene expression of TNF-α. Caspase-3 activator 4 decreases the protein expression of cleaved caspases 3/caspases 3 .

HY-P10452

Ac-LEVDGWK(Dnp)-NH2	Caspase	Others
Ac-LEVDGWK(Dnp)-NH2 is a substrate for *Caspase-3, and can be used to detect Caspase-3* activity .

HY-D1432

FITC-C6-DEVD-FMK	Fluorescent Dye	Cancer
FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .

HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dye	Others
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-W415273

Caspase-3-IN-2	Ser/Thr Protease HIV Protease Caspase	Infection
Caspase-3-IN-2 (Compound 4d) is the inhibitor for α-Chymotrypsin. Caspase-3-IN-2 also exhibits inhibitory activity against HIV protease and *caspase 3* with an inhibition rate of 57% and 51% at 100 μM .

HY-W792412

Z-YVAD-CMK	Caspase	Cancer
Z-YVAD-CMK is a *caspase-1* and *caspase-3* inhibitor .

HY-P3234

Ac-ESMD-CHO	Casein Kinase	Others
Ac-ESMD-CHO is an inhibitor of *caspase-3* and *caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3* precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .

HY-W033813

Caspase-3/7 Inhibitor I	Caspase Apoptosis	Cancer
Caspase-3/7 inhibitor I is a potent and reversible inhibitor of *caspase-3* and *caspase-7, with K_is of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis* in Camptothecin (HY-16560)-treated Jurkat cells and in chondrocytes .**

HY-P1169

Ac-IETD-AFC 1 Publications Verification	Caspase	Others
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-155389

Caspase-3 activator 2	Caspase	Cancer
Caspase-3 activator 2 (Compound 2f) is a *caspase 3* activator that induces apoptosis and can be used in cancer research. Caspase-3 activator 2 is cytotoxic to HL-60 cells and K562 cells, with IC₅₀ values of 33.52 μM and 76.90 μM respectively .

HY-152756

Caspase-3/7 activator 2	Apoptosis Caspase	Cancer
Caspase-3/7 activator 2 is an effective activator of *Caspase-3/7. Caspase-3/7 activator 2 has tumor selectivity, anti-proliferative activity and high Apoptosis*-inducing ability .

HY-152748

Caspase-3/7 activator 1	Apoptosis Caspase	Cancer
Caspase-3/7 activator 1 is an effective activator of *Caspase-3/7. Caspase-3/7 activator 1 has tumor selectivity, anti-proliferative activity and high Apoptosis*-inducing ability .

HY-152758

Caspase-3/7 activator 3	Apoptosis Caspase	Cancer
Caspase-3/7 activator 3 is an effective activator of *Caspase-3/7. Caspase-3/7 activator 3 has tumor selectivity, anti-proliferative activity and high Apoptosis*-inducing ability .

HY-P1986

Z-DEVD-AFC	Caspase	Cancer
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .

HY-155390

Caspase-3 activator 3	Caspase Apoptosis	Cancer
Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant *caspase 3* activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC₅₀ values of 42.89 and 33.61 μM, respectively .

HY-P1094

AZ-10417808	Apoptosis Caspase	Inflammation/Immunology Cancer
AZ-10417808 is a selective *caspase-3* inhibitor. AZ-10417808 blocks apoptosis signaling pathway by inhibiting *caspase-3* activity. AZ-10417808 can be used to study the effect of nicotine on plasmacytoid dendritic cell migration .

HY-P2614

Mca-DEVDAP-K(Dnp)-OH	Caspase	Others
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for *caspase-3* .

HY-P1001

Ac-DEVD-CHO 35+ Cited Publications	Caspase	Cancer
Ac-DEVD-CHO is a specific *Caspase-3* inhibitor with a K_i value of 230 pM.

HY-P6285

Z-TPE-2DEVD	Fluorescent Dye Caspase	Cancer
Z-TPE-2DEVD is a specific probe for caspase-3 .

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Bcl-2 Family Caspase	Neurological Disease
Thevetiaflavone could upregulate the expression of Bcl-2 and downregulate that of Bax and *caspase-3*.

HY-12466

Z-DEVD-FMK Maximum Cited Publications 93 Publications Verification	Caspase	Cancer
Z-DEVD-FMK is a specific and irreversible *caspase-3* inhibitor with an IC₅₀ of 18 μM .

HY-19696

Tauroursodeoxycholate 70+ Cited Publications Tauroursodeoxycholic acid; TUDCA; UR 906	ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK*.

HY-155612

M826	Caspase	Neurological Disease
M826 is a potent, selective and reversible non-peptide *caspase-3* inhibitor with an IC₅₀ value of 0.005 μM for enzymatic activity against caspase-3. M826 displays potent anti-apoptotic activity in animal models in vitro and in vivo. M826 can be used for nervous system diseases research .

HY-103667

2-HBA 3 Publications Verification	Caspase	Cancer
2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate *caspase-3* and *caspase-10*.

HY-19696A

Tauroursodeoxycholate sodium 70+ Cited Publications Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium	ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK*.

HY-P5936

Ac-AAVALLPAVLLALLAP-DEVD-CHO DEVD-CHO-CPP 32	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible *caspase-3* inhibitor .

HY-103347

M50054	Apoptosis	Inflammation/Immunology
M50054 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC₅₀ of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia .

HY-P0034

Ac-DEVD-CMK Caspase-3 Inhibitor III	Caspase Apoptosis	Metabolic Disease
Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible *caspase-3* inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis .

HY-P2615

Ac-VDVAD-AFC	Fluorescent Dye	Cancer
Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-P2615A

Ac-VDVAD-AFC TFA	Fluorescent Dye	Cancer
Ac-VDVAD-AFC TFA is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC TFA can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-19696B

Tauroursodeoxycholate dihydrate 70+ Cited Publications Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK* .

HY-P0034A

Ac-DEVD-CMK TFA 2 Publications Verification Caspase-3 Inhibitor III TFA	Caspase Apoptosis	Metabolic Disease
Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible *caspase-3* inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis .

HY-111675

Ac-FLTD-CMK 5+ Cited Publications	Caspase Pyroptosis	Inflammation/Immunology
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against *caspases-1* (IC₅₀ of 46.7 nM), *caspases-4* (IC₅₀ of 1.49 μM), *caspases-5* (IC₅₀ of 329 nM), and *caspases-11* , but not the apoptotic caspases such as caspase-3 .

HY-103346

MMPSI	Caspase Apoptosis	Cardiovascular Disease
MMPSI is a potent and selective small molecule *caspase 3* and caspase 7 inhibitor with an IC₅₀ of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection .

HY-19696S

Tauroursodeoxycholate-d5	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₅ is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S1

Tauroursodeoxycholate-d4 Tauroursodeoxycholic acid-d₄; TUDCA-d₄; UR 906-d₄	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-10396

Emricasan 35+ Cited Publications PF 03491390; IDN-6556	Caspase Flavivirus	Infection Neurological Disease Cancer
Emricasan (PF 03491390) is an orally active and irreversible *pan-caspase* inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in *caspase-3* activity and protected human cortical neural progenitors .

HY-19696AS

Tauroursodeoxycholate-d4 sodium Tauroursodeoxycholic acid-d₄ sodium; TUDCA-d₄ sodium; UR 906-d₄ sodium	Isotope-Labeled Compounds ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N3376

Liriodenine Spermatheridine; VLT045	Apoptosis	Cancer
Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities . Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9 .

HY-19696S2

Tauroursodeoxycholate-d4-1 Tauroursodeoxycholic acid-d₄-1; TUDCA-d₄-1; UR 906-d₄-1	Isotope-Labeled Compounds ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-155613

M867	Caspase	Cancer
M867 is a selective and reversible inhibitor of *caspase-3* with an IC₅₀ of 1.4 nM and K_i of 0.7 nM. M867 has anti apoptotic activity .

HY-N6681

15-Acetoxyscirpenol	Caspase Bacterial Apoptosis Antibiotic	Infection
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other *caspases* independent of caspase-3 .

HY-12294B

(Rac)-PEAQX (Rac)-NVP-AAM077	iGluR Caspase Apoptosis	Neurological Disease
(Rac)-PEAQX is a NMDA receptor agonist. (Rac)-PEAQX can promote the activation of *caspase-3* and induce cell apoptosis in cortical striatal slice cultures .

HY-117804

8-Br-cADPR 8-Bromo-Cyclic ADP-Ribose	TRP Channel	Neurological Disease
8-Br-cADPR is a potent cADPR antagonist. 8-Br-cADPR reduces renal damage and the expression of *caspase-3* and TRPM2 .

HY-P3363

Z-DEVD-AMC	Caspase	Cancer
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .

HY-19696R

Tauroursodeoxycholate (Standard)	ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate (Standard) is the analytical standard of Tauroursodeoxycholate. This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

Cat. No.	Product Name	Type

HY-P1169

Ac-IETD-AFC 1 Publications Verification	Fluorescent Dyes/Probes
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-P1986

Z-DEVD-AFC	Fluorescent Dyes/Probes
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .

HY-P3363

Z-DEVD-AMC	Chromogenic Substrates
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .

HY-P1003

Ac-DEVD-AMC 4 Publications Verification	Chromogenic Substrates
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

HY-D0086

DIDS sodium salt Maximum Cited Publications 14 Publications Verification MDL101114ZA	Dyes
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .

HY-D1432

FITC-C6-DEVD-FMK	Fluorescent Dyes/Probes
FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .

HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dyes/Probes
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-P2614

Mca-DEVDAP-K(Dnp)-OH	Chromogenic Substrates
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for *caspase-3* .

HY-W338079

Ac-Asp-Glu-Val-Asp-pNA	Fluorescent Dyes/Probes
Ac-Asp-Glu-Val-Asp-pNA is a peptidic substrate of caspase-3/7 .

HY-P3110

Ac-DNLD-AMC	Dyes
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

Cat. No.	Product Name	Type

HY-Y1881B

Copper sulfate pentahydrate, for cell culture, 98%

Buffer Reagents

Copper sulfate pentahydrate, for cell culture, 98% is a biochemical reagent. Copper sulfate pentahydrate, for cell culture, 98% reduces the production of ROS and the expression levels of MyD88 as well as c-Rel genes. Copper sulfate pentahydrate, for cell culture, 98% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, for cell culture, 98% is cytotoxic to various cells .

HY-NP019

Agkistrodon halys batroxobin	Native Proteins
Agkistrodon halys batroxobin is a thrombin-like serine protease. Agkistrodon halys batroxobin reduces the expression of Sirt1 and extracellular signal-regulated kinase activation in brain tissue. Agkistrodon halys batroxobin reduces cleaved caspase-3 expression and inhibits neuronal apoptosis in rat .

HY-W250111

Carboxymethyl chitosan

Biochemical Assay Reagents

Carboxymethyl chitosan is a water-soluble derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma .

HY-D0848

N,N'-Methylenebisacrylamide

Bisacrylamide; MBA; Methylenebisacrylamide; N,N-Methylenebisacrylamide

Thickeners

N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel .

Cat. No.	Product Name	Target	Research Area

HY-P1169

Ac-IETD-AFC 1 Publications Verification	Caspase	Others
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-P1986

Z-DEVD-AFC	Caspase	Cancer
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .

HY-P1001

Ac-DEVD-CHO Maximum Cited Publications 37 Publications Verification	Caspase	Cancer
Ac-DEVD-CHO is a specific *Caspase-3* inhibitor with a K_i value of 230 pM.

HY-P10452

Ac-LEVDGWK(Dnp)-NH2	Caspase	Others
Ac-LEVDGWK(Dnp)-NH2 is a substrate for *Caspase-3, and can be used to detect Caspase-3* activity .

HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dye	Others
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-W792412

Z-YVAD-CMK	Caspase	Cancer
Z-YVAD-CMK is a *caspase-1* and *caspase-3* inhibitor .

HY-P3234

Ac-ESMD-CHO	Casein Kinase	Others
Ac-ESMD-CHO is an inhibitor of *caspase-3* and *caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3* precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .

HY-P2614

Mca-DEVDAP-K(Dnp)-OH	Caspase	Others
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for *caspase-3* .

HY-P6285

Z-TPE-2DEVD	Fluorescent Dye Caspase	Cancer
Z-TPE-2DEVD is a specific probe for caspase-3 .

HY-P5936

Ac-AAVALLPAVLLALLAP-DEVD-CHO DEVD-CHO-CPP 32	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible *caspase-3* inhibitor .

HY-P0034

Ac-DEVD-CMK Caspase-3 Inhibitor III	Caspase Apoptosis	Metabolic Disease
Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible *caspase-3* inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis .

HY-P2615

Ac-VDVAD-AFC	Fluorescent Dye	Cancer
Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-P2615A

Ac-VDVAD-AFC TFA	Fluorescent Dye	Cancer
Ac-VDVAD-AFC TFA is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC TFA can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-P0034A

Ac-DEVD-CMK TFA 2 Publications Verification Caspase-3 Inhibitor III TFA	Caspase Apoptosis	Metabolic Disease
Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible *caspase-3* inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis .

HY-P3363

Z-DEVD-AMC	Caspase	Cancer
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .

HY-108312A

AC-VEID-CHO TFA	Caspase	Neurological Disease
AC-VEID-CHO (TFA) is a peptide-derived *caspase* inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .

HY-P2228

Chlamydocin	HDAC Apoptosis	Cancer
Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC₅₀ of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .

HY-P10162

Ac-DMQD-AMC	Caspase	Cancer
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .

HY-P1006

Ac-DEVD-pNA 1 Publications Verification	Caspase	Others
Ac-DEVD-pNA is a ligand for *caspase-3/-7* and related cysteine proteases .

HY-P1003

Ac-DEVD-AMC 4 Publications Verification	Fluorescent Dye	Others
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

HY-P10083

Ac-VQVD-pNA	Fluorescent Dye	Others
Ac-VQVD-pNA is a chromogenic substrate of *caspase* 3 .

HY-P10656

Ac-DEVDD-TPP	Apoptosis Pyroptosis	Cancer
Ac-DEVDD-TPP is a porphyrin derivative that can be converted into D-TPP by caspase-3 cleavage and laser irradiation. The formed porphyrin nanofibers can effectively induce Apoptosis and Pyroptosis. Ac-DEVDD-TPP has antitumor activity .

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin	Neurological Disease
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .

HY-P3528

GPR	Caspase Apoptosis	Neurological Disease
GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting *caspase-3/p53* dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).

HY-P3110

Ac-DNLD-AMC	Fluorescent Dye	Others
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

HY-P3560

Edratide TV 4710	Apoptosis	Inflammation/Immunology
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) .

HY-P4900

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone	Caspase	Others
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that binds irreversibly to activated *caspase*-3 in apoptotic cells. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy .

HY-P4400

Z-VDVAD-AFC	Fluorescent Dye	Others
Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals .

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-P2374

Ac-DMQD-CHO	Caspase Apoptosis	Neurological Disease
Ac-DMQD-CHO is a selective inhibitor for *caspase 3, with IC₅₀* of 39 nM. Ac-DMQD-CHO reduces apoptosis, and exhibits neuroprotective efficacy .

HY-136733

Ac-DNLD-CHO Ac-Asp-Asn-Leu-Asp-CHO	Caspase	Infection Neurological Disease
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a *Caspase-3/7* inhibitor (IC₅₀: 9.89, 245 nM respectively; K_i ^app: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases .

HY-P5156

BDS-I	Potassium Channel	Neurological Disease
BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death .

HY-P4403

Z-DEVD-R110 (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110	Fluorescent Dye Apoptosis Caspase	Others
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)₂-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .

HY-P1823

C-Reactive Protein (CRP) (174-185)	Akt mTOR Caspase	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
C-Reactive Protein (CRP) is an anti-pneumococcal plasma protein that can serve as an inflammatory marker. C-Reactive protein can protect mice from pneumococcal infection by activating complement. C-Reactive protein can inhibit the activation of *caspase-3/9* through the CD64/AKT/mTOR pathway, thereby promoting chemotherapy resistance in mice with tongue squamous cell carcinoma .

HY-P2569

Malformin A1	Apoptosis	Cancer
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .

HY-P3259

AY254	Protease Activated Receptor (PAR)	Inflammation/Immunology Cancer
AY254 is an analogue of AY77 (HY-138951). AY254 is ERK-biased PAR2 agonist with an EC₅₀ of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling

HY-P1740

RGD peptide (GRGDNP) 5 Publications Verification	Integrin Apoptosis Caspase	Inflammation/Immunology
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation .

HY-P1740A

RGD peptide (GRGDNP) (TFA) 5 Publications Verification	Integrin Apoptosis	Inflammation/Immunology Cancer
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation .

Cat. No.	Product Name

HY-K2611

Caspase 3 Activity Assay Kit 1 Publications Verification
MCE Caspase 3 Activity Assay Kit provides a simple and convenient way for detecting the activity of detection of Caspase 3 activity that based on the spectrophotometric.

HY-K1088

*VF 488 Caspase 3* Assay Kit for Live Cells**
MCE VF 488 Caspase 3 Assay Kit for Live Cells uses a fluorescent substrate with cell membrane permeability to detect Caspase 3 activity in live cells.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Bcl-2 Family Caspase
Thevetiaflavone could upregulate the expression of Bcl-2 and downregulate that of Bax and *caspase-3*.

HY-19696

Tauroursodeoxycholate Maximum Cited Publications 75 Publications Verification Tauroursodeoxycholic acid; TUDCA; UR 906	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK*.

HY-19696A

Tauroursodeoxycholate sodium Maximum Cited Publications 75 Publications Verification Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK*.

HY-19696B

Tauroursodeoxycholate dihydrate Maximum Cited Publications 75 Publications Verification Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK* .

HY-N3376

Liriodenine Spermatheridine; VLT045	Alkaloids Structural Classification Classification of Application Fields Magnoliaceae Source classification Pyridine Alkaloids Liriodendron chinense (Hemsl.) Sarg. Plants Disease Research Fields Cancer	Apoptosis
Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities . Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9 .

HY-N6681

15-Acetoxyscirpenol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Caspase Bacterial Apoptosis Antibiotic
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other *caspases* independent of caspase-3 .

HY-N6861

Lucidenic acid B	Triterpenes Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells .

HY-N2490

Dehydrotrametenolic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Poria cocos Plants Inflammation/Immunology Disease Research Fields	Caspase Apoptosis
Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through *caspase-3* pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects .

HY-19696R

Tauroursodeoxycholate (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate (Standard) is the analytical standard of Tauroursodeoxycholate. This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N13123

Tenacissoside C	Triterpenes Structural Classification Terpenoids Marsdenia tenacissima (Roxb.) Moon Source classification Asclepiadaceae Plants	Apoptosis
Tenacissoside C is an anti-cancer compound that inhibits angiogenesis. Tenacissoside C induces apoptosis in cancer cells by down-regulating the expression of anti-apoptotic factors and activating caspase-9 and caspase-3. Tenacissoside C also causes cell cycle arrest in cancer cells and induces apoptosis through the mitochondrial pathway.

HY-N7569

Demethoxyfumitremorgin C	Structural Classification Alkaloids Microorganisms Source classification Marine natural products Other marine organisms Indole Alkaloids	Apoptosis Caspase PPAR
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates *caspase*-3, -8, and -9, leading to PARP/ cleavage .

HY-W012499

N-Acetyl-L-methionine 1 Publications Verification N-Acetylmethionine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Caspase Mitochondrial Metabolism
N-Acetyl-L-methionine is a dietary supplementation. N-Acetyl-L-methionine increases *caspase-3* activity and inhibits mitochondrial activity. N-Acetyl-L-methionine promotes lactation and improves meat quality .

HY-N8464

Juncuenin D	Structural Classification Natural Products Juncaceae Source classification Plants Juncus acutus L.	Bacterial
Juncuenin D induces *caspase-3*-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus .

HY-N12503

Patuletin	Structural Classification Flavonols Flavonoids Source classification Amaranthaceae Plants Spinacia oleracea L.	Apoptosis Caspase
Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce *caspase-3* activation .

HY-N11648

Ganoderic acid T1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis Caspase
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

HY-W046353

2-Methoxycinnamaldehyde o-Methoxycinnamaldehyde	Structural Classification Cinnamomum cassia (L.) D. Don Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae Disease Research Fields Cancer	Apoptosis
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .

HY-W106456

3-Methoxy-9H-Carbazole	Structural Classification Alkaloids Pyrrole Alkaloids Clausena heptaphylla (Roxb.) Wight & Arn. Source classification Rutaceae Plants	Caspase Reactive Oxygen Species Apoptosis
3-Methoxy-9H-Carbazole induces *caspase-3* activities and the cellular generation of eactive oxygen species. 3-Methoxy-9H-Carbazole inhibits cancer cell proliferation and induces apoptosis .

HY-N13891

Arisostatin A	Structural Classification Natural Products Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Apoptosis
Arisostatin A, a microbial secondary metabolite, is an antibiotic against Gram-positive bacteria and shown to possess potent anti-tumor properties. Arisostatin A induces apoptosis through the activation of caspase-3 and reactive oxygen species (ROS) generation in AMC-HN-4 cells .

HY-130073

Amorfrutin A	Structural Classification Simple Phenylpropanols Leguminosae Source classification Amorpha fruticosaL. Phenylpropanoids Plants	NF-κB Apoptosis
Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis .

HY-N0702

Tenuifolin	Triterpenes Structural Classification Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	Beta-secretase Cholinesterase (ChE)
Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).

HY-N1970

5,7-Dihydroxychromone 1 Publications Verification	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Isoflavones	Keap1-Nrf2 Arenavirus Caspase PARP
5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated *caspase-3* and *caspase-9* and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .

HY-N0905

Ginsenoside Rh4	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Bcl-2 Family Caspase Apoptosis Autophagy Endogenous Metabolite
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, *caspase 3, caspase* 8, and caspase 9. Ginsenoside Rh4 also induces autophagy.

HY-N0809

Sesamolin 2 Publications Verification	Structural Classification Sesamum indicum Linn. Source classification Other Phenylpropanoids Phenylpropanoids Pedaliaceae Plants	p38 MAPK JNK Caspase Reactive Oxygen Species NF-κB
Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and *caspase-3* but not ERK-MAPK expression. Sesamolin is orally active .

HY-N7930

Crenulatin	Structural Classification Classification of Application Fields Source classification Crassulaceae Other Diseases Plants Disease Research Fields Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Saccharides	Others
Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity .

HY-Y0152

Cinchonine 4 Publications Verification (8R,9S)-Cinchonine; LA40221	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Cancer	Apoptosis Parasite Autophagy Caspase Calcium Channel
Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

HY-W046353R

2-Methoxycinnamaldehyde (Standard)	Structural Classification Cinnamomum cassia (L.) D. Don Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae	Apoptosis
2-Methoxycinnamaldehyde (Standard) is the analytical standard of 2-Methoxycinnamaldehyde. This product is intended for research and analytical applications. 2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .

HY-N6690

Destruxin B	Infection Structural Classification Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields	Bcl-2 Family Caspase Apoptosis
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells . Destruxin B significantly activates *caspase-3* and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo .

HY-124344

Avenanthramide C	Structural Classification Simple Phenylpropanols Avena sativa Linn. Gramineae Source classification Phenylpropanoids Plants	Interleukin Related
Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .

HY-W012499R

N-Acetyl-L-methionine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
N-Acetyl-L-methionine (Standard) is the analytical standard of N-Acetyl-L-methionine. This product is intended for research and analytical applications. N-Acetyl-L-methionine is a dietary supplementation. N-Acetyl-L-methionine increases *caspase-3* activity and inhibits mitochondrial activity. N-Acetyl-L-methionine promotes lactation and improves meat quality .

HY-N15380

4,4′-Secalonic acid D	Structural Classification Xanthones Animals Source classification Phenols	PARP Reactive Oxygen Species Caspase Apoptosis Pyroptosis
4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the *caspase-3/GSDME* pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity .

HY-N15315

Triptriolide	Triterpenes Structural Classification Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants	Apoptosis MAP3K NF-κB
Triptriolide inhibits Puromycin aminonucleoside PAN (HY-15695)-induced apoptosis in mouse podocytes through regulation of Bcl-2 family proteins and inhibition of Caspase-3. Triptriolide promotes the cell survival, protects and restores the podocyte function through activation of TAK1-NF-κB signaling pathway and upregulation of podocin .

HY-W748591

Cannflavin A	Structural Classification Flavonoids Cannabis sativa L Flavones Source classification Plants Moraceae	Apoptosis Amyloid-β
Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage .

HY-N0702R

Tenuifolin (Standard)	Triterpenes Structural Classification Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	Beta-secretase Cholinesterase (ChE)
Tenuifolin (Standard) is the analytical standard of Tenuifolin. This product is intended for research and analytical applications. Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD) .

HY-N0809R

Sesamolin (Standard)	Structural Classification Sesamum indicum Linn. Source classification Other Phenylpropanoids Phenylpropanoids Pedaliaceae Plants	p38 MAPK JNK Caspase
Sesamolin (Standard) is the analytical standard of Sesamolin. This product is intended for research and analytical applications. Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesamolin potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression .

HY-N2013

Aristolactam I 1 Publications Verification Aristololactam; Aristolactam	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Caspase Apoptosis
Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a *caspase-3*-dependent pathway .

HY-W748509

Pipernonaline	Piper longum Linn. Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-N1440

Koumine	Alkaloids Structural Classification Classification of Application Fields Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Inflammation/Immunology Disease Research Fields Indole Alkaloids	Bcl-2 Family
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N1970R

5,7-Dihydroxychromone (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Isoflavones	Keap1-Nrf2 Arenavirus Caspase PARP
5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone. This product is intended for research and analytical applications. 5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .

HY-Y0152R

Cinchonine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants	Apoptosis Parasite Autophagy Caspase Calcium Channel
Cinchonine (Standard) is the analytical standard of Cinchonine. This product is intended for research and analytical applications. Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

HY-N0361

Dihydrocapsaicin 2 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Source classification Phenols Metabolic Disease Solanaceae Plants Disease Research Fields	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and *Caspase-3* expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-W040329

2'-Deoxyadenosine	Structural Classification Natural Products Immune System Disorder Classification of Application Fields Source classification Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite Caspase Apoptosis
2'-Deoxyadenosine is a purine nucleoside composed of Adenine (HY-B0152) and 2'-deoxyribose. 2'-Deoxyadenosine activates *Caspase-3* and promotes Apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase. 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .

HY-W748591R

Cannflavin A (Standard)	Structural Classification Flavonoids Cannabis sativa L Flavones Source classification Plants Moraceae	Apoptosis Amyloid-β
Cannflavin A (Standard) is the analytical standard of Cannflavin A. This product is intended for research and analytical applications. Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage .

HY-N0763

Angelicin 5+ Cited Publications Isopsoralen	Structural Classification Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating *caspase-9* and *caspase-3*.

HY-N3584

Paris saponin VII 3 Publications Verification Chonglou Saponin VII	Structural Classification Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of *Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt*. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N1440R

Koumine (Standard)	Alkaloids Structural Classification Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids	Bcl-2 Family
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N2877

Annonacin	Structural Classification Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Source classification Plants Annonaceae Disease Research Fields	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways .

HY-N2013R

Aristolactam I (Standard)	Structural Classification Natural Products other families Source classification Plants	Caspase Apoptosis
Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway .

HY-N15449

Vicanicin	Structural Classification Natural Products Microorganisms Source classification	HSP Caspase Apoptosis Reactive Oxygen Species
Vicanicin is a depsidone compound found in lichens. Vicanicin inhibits the expression of Hsp70, regulates the redox-sensitive mechanisms within cells, promotes the increase of reactive oxygen species (ROS) in cancer cells, changes the Bax/Bcl-2 ratio, activates caspase-3, and triggers apoptosis. Vicanicin inhibits cell growth and induces apoptosis in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. Vicanicin is promising for research of prostate cancer .

HY-N0361R

Dihydrocapsaicin (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-N1486R

Ursonic acid (Standard)	Triterpenes Structural Classification Ziziphus jujuba Terpenoids Source classification Plants Endogenous metabolite Rhamnaceae	Apoptosis Endogenous Metabolite NF-κB
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

Cat. No.	Product Name	Chemical Structure

HY-19696S

Tauroursodeoxycholate-d5
Tauroursodeoxycholate-d₅ is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696AS

Tauroursodeoxycholate-d4 sodium
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃ is the deuterium labeled Dihydrocapsaicin (HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-19696S1

Tauroursodeoxycholate-d4
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S2

Tauroursodeoxycholate-d4-1
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-W015879S

2-Heptanol-d5
2-Heptanol-d₅ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

HY-W020050S

Cystamine-d8 dihydrochloride

Cystamine-d₈ (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].

HY-B0347S3

Lacidipine-13C4

Lacidipine- ¹³C₄ is ¹³C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-B0347S1

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

Cat. No.	Product Name		Classification

HY-W040329

2'-Deoxyadenosine		Nucleosides and their Analogs
2'-Deoxyadenosine is a purine nucleoside composed of Adenine (HY-B0152) and 2'-deoxyribose. 2'-Deoxyadenosine activates *Caspase-3* and promotes Apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase. 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .

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