VHL - von Hippel-Lindau tumor suppressor Gene

Homo sapiens

Also known as RCA1; VHL1; pVHL; HRCA1

Gene ID: 7428 | Gene type: protein coding

About VHL

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:10,141,778-10,153,667 (from NCBI)

This gene has 6 transcripts (splice variants), 168 orthologues, 1 paralogue and is associated with 102 phenotypes. Ubiquitous expression in lymph node (RPKM 12.2), spleen (RPKM 10.0) and 25 other tissues.

Summary

This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many Other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022]

VHL Products(3)

mRNA	Protein	Name
NM_000551.4	NP_000542.1	von Hippel-Lindau disease tumor suppressor isoform 1
NM_001354723.2	NP_001341652.1	von Hippel-Lindau disease tumor suppressor isoform 3
NM_198156.3	NP_937799.1	von Hippel-Lindau disease tumor suppressor isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11641274	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	11641274	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	10205047	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7660122	GOA
enables transcription elongation factor activity	IDA IDA: Inferred from direct assay	7660122	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	24899725	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid fibril formation	EXP EXP: Inferred from Experiment	34431623	GOA
involved in amyloid fibril formation	IDA IDA: Inferred from direct assay	34431623	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	34290272	GOA
involved in negative regulation of autophagy	IDA IDA: Inferred from direct assay	30902965	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	23338840	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23338840	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23338840	GOA
involved in negative regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	23338840	GOA
involved in negative regulation of signal transduction	EXP EXP: Inferred from Experiment	23338840	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11641274	GOA
involved in negative regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	7660122	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17973242	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	34290272	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	24899725	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	12169691	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15824735	GOA
involved in regulation of cellular response to hypoxia	EXP EXP: Inferred from Experiment	10205047	GOA
involved in regulation of gene expression	EXP EXP: Inferred from Experiment	15824735	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	17973242	GOA
involved in regulation of gene expression	IEP IEP: Inferred from expression pattern	15824735	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	34290272	GOA
is active in intracellular non-membrane-bounded organelle	EXP EXP: Inferred from Experiment	14963040	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VHL Protein Structure

VHL

0
100
200
213 a.a.

Protein Preferred Names

Protein Names

von Hippel-Lindau disease tumor suppressor

elongin binding protein

VHL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VHL	P40337	FN1	Homo sapiens	P02751	Anti Tag CoIP	18323857
Intra	VHL	P40337	RNF139	Homo sapiens	Q8WU17	Anti Bait CoIP	12032852
Cross	VHL	P40337	P0C6X7-PRO_0000037322	Human SARS coronavirus	P0C6X7-PRO_0000037322	Anti Tag CoIP	25732088
Cross	VHL	P40337	P0C6X7-PRO_0000037322	Human SARS coronavirus	P0C6X7-PRO_0000037322	Confocal	25732088
Cross	VHL	P40337	P0C6X7-PRO_0000037322	Human SARS coronavirus	P0C6X7-PRO_0000037322	Pull Down	25732088
Intra	VHL	P40337	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	17350623
Intra	VHL	P40337	PRKCZ	Homo sapiens	Q05513	Imaging	17350623
Intra	VHL	P40337	RACK1	Homo sapiens	P63244	Anti Tag CoIP	20871634
Intra	VHL	P40337	RACK1	Homo sapiens	P63244	Y2H	20871634
Intra	VHL	P40337	RACK1	Homo sapiens	P63244	Pull Down	20871634
Cross	VHL	P40337	Hif1a	Mus musculus	Q61221	Anti Bait CoIP	11292862
Cross	VHL	P40337	Hif1a	Mus musculus	Q61221	Far-WB	11292862
Intra	VHL	P40337	HIF1A	Homo sapiens	Q16665	Anti Bait CoIP	11292862
Intra	VHL	P40337	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	21602890
Intra	VHL	P40337	HIF1A	Homo sapiens	Q16665	Pull Down	11292862
Intra	VHL	P40337	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	34818544
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Bait CoIP	15601820
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	33961781
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	15601820
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Pull Down	25661653
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	18323857
Intra	VHL	P40337	CUL2	Homo sapiens	Q13617	Anti Bait CoIP	17353931
Intra	VHL	P40337	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	VHL	P40337	TGM2	Homo sapiens	P21980	Anti Bait CoIP	21625219
Intra	VHL	P40337	TGM2	Homo sapiens	P21980	Enzymatic Study	21625219
Intra	VHL	P40337	TGM2	Homo sapiens	P21980	Anti Tag CoIP	21625219
Intra	VHL	P40337	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VHL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76124	VHL Protein, Human (His)	P40337 (M1-D213)	≥95%

Related Diseases

Diseases

Alias

Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease	Vhl
Vhl Syndrome	VHLS
Von Hippel-Lindau Syndrome, Modifier Of	Hippel Lindau Syndrome
Angiomatosis Retinae	Cerebelloretinal Angiomatosis, Familial
Hippel-Lindau Disease	Familial Cerebelloretinal Angiomatosis
Lindau Disease	VHLD

Erythrocytosis, Familial, 2

Chuvash Polycythemia	ECYT2
Familial Erythrocytosis 2	Autosomal Recessive Benign Erythrocytosis
Polycythemia, Vhl-Dependent	Chuvash Erythromatosis
Chuvash Type Polycythemia	Chuvash Erythrocytosis
Von Hippel-Lindau-Dependent Polycythemia	Polycythemia Chuvash Type
Vhl-Dependent Polycythemia	Erythrocytosis, Familial, Type 2

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Retinal Hemangioblastoma

Capillary Hemangioma Of Retina

Acute Biphenotypic Leukemia

Mixed Phenotype Acute Leukemia	Acute Leukemia Of Ambiguous Lineage
Acute Undifferentiated Leukemia	Acute Leukemia Of Indeterminate Lineage
Hybrid Acute Leukemia	Mixed Lineage Acute Leukemia
All With Myeloid Markers	Aml With Lymphoid Markers
Acute Leukemia Of Undetermined Lineage	Bal
Biphenotypic Acute Leukemia	Undifferentiated Acute Leukemia
Mpal	Acute Myeloid Leukemia, Minimal Differentiation, Fab M0
Leukemia, Biphenotypic, Acute

Myasthenic Syndrome, Congenital, 6, Presynaptic

Familial Infantile Myasthenia	CMS6
Cmsea	Congenital Myasthenic Syndrome 6
Familial Infantile Myasthenia Gravis 2	Fimg2
Myasthenic Syndrome, Congenital, Associated With Episodic Apnea	Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea
Congenital Myasthenic Syndrome Type Ia2, Formerly	Cms1a2, Formerly
Cms Ia2, Formerly	Myasthenia, Familial Infantile, Formerly
Fim, Formerly	Myasthenia Gravis, Familial Infantile, 2, Formerly
Fimg2, Formerly	Cms Ia2
Cms1a2	Congenital Myasthenic Syndrome 6, Presynaptic
Congenital Myasthenic Syndrome Type Ia2	Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea
Fim	Cms1a
Cms-Ea	Cms Ia
Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea	Congenital Myasthenic Syndrome Type 1a
Congenital Myasthenic Syndrome Type Ia	Myasthenic Syndrome, Congenital, Type 6, Presynaptic

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

Hereditary Paraganglioma-Pheochromocytoma Syndromes

Hereditary Pheochromocytoma-Paraganglioma	Hereditary Paraganglioma-Pheochromocytoma
Familial Pheochromocytoma-Paraganglioma	Paragangliomas 2
Paragangliomas 3	Paragangliomas 4
Sdhx-Related Paraganglioma-Pheochromocytoma	Familial Paraganglioma Syndrome
Familial Paraganglioma-Pheochromocytoma Syndromes	Fpgl
Fpgl/Pheo	Paragangliomas 1
Paraganglioma

Bap1 Tumor Predisposition Syndrome

Bap1-Related Tumor Predisposition Syndrome	Common Syndrome
Bap1 Cancer Syndrome	Bap1-Tpds
Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms	Tumor Predisposition Syndrome
Tumor Susceptibility Linked To Germline Bap1 Mutations	Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms
Tumor Predisposition

Inherited Cancer-Predisposing Syndrome

Hereditary Cancer-Predisposing Syndrome

Hemangioblastoma

Capillary Hemangioblastoma

Microcystic Adenoma

Adenoma Microcystic

Adenoma, Microcystic

Sporadic Pheochromocytoma/Secreting Paraganglioma

Cystadenoma

Cystoma

Craniopharyngioma

Polycythemia

Erythrocythemia	Polycythemia Vera
Polycythaemia Due To High Altitude

Paraganglioma

Chemodectoma	Glomus Body Tumor
Paragangliomas	Carotid Body Paraganglioma
Extra-Adrenal Paraganglioma

Primary Polycythemia

Familial Erythrocytosis	Familiar Polycythemia
Benign Familial Polycythemia	Congenital Erythrocytosis
Familial Polycythemia	Hereditary Erythrocytosis
Primary Familial Polycythemia	Erythrocytosis, Familial
Polycythemia Vera	Primary Familial Polycythaemia
Primary Inherited Polycythaemia

Multiple Endocrine Neoplasia

Men	Multiple Endocrine Adenomatosis
Multiple Endocrine Neoplasia Syndrome	Adenomatosis, Familial Endocrine
Endocrine Neoplasia, Multiple	Familial Endocrine Adenomatosis
Mea	Multiple Endocrine Neoplasms
Multiple Endocrine Neoplasia Type 1

Hemangioma Of Liver

Hepatic Hemangioma	Angioma Of Liver
Hepatic Angioma

Collecting Duct Carcinoma

Kidney Medullary Carcinoma	Renal Medullary Carcinoma
Bdc	Bellini Carcinoma
Bellini Duct Carcinoma	Cdc
Collecting Duct Carcinoma Of The Kidney	Renal Cell Adenocarcinoma
Carcinoma Of Renal Collecting Duct	Renal Carcinoma, Collecting Duct Type
Renal Cell Carcinoma	Bellini'S Duct Carcinoma
Renal Collecting Duct Carcinoma	Adenocarcinoma Of Kidney

Kidney Cancer

Renal Cancer	Renal Carcinoma
Kidney Neoplasm	Malignant Neoplasm Of Kidney Except Pelvis
Malignant Tumour Of Kidney	Kidney Neoplasms
Cancer, Kidney	Cancer, Renal
Malignant Neoplasm Of Kidney	Renal Cell Carcinoma

Hepatoblastoma

Tuberous Sclerosis

Tuberous Sclerosis Syndrome	Bourneville'S Disease
Epiloia	Cerebral Sclerosis
Tuberose Sclerosis	Tuberous Sclerosis 1
Bourneville Disease	Bourneville Phakomatosis
Pringle'S Disease

Multiple Endocrine Neoplasia, Type Iia

Multiple Endocrine Neoplasia Type 2a	Sipple Syndrome
Multiple Endocrine Neoplasia Type 2	MEN2A
Men2	Ptc Syndrome
Multiple Endocrine Neoplasia, Type 2	Multiple Endocrine Neoplasia Iia
Men 2a	Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
Multiple Endocrine Neoplasia, Type 2a	Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
Multiple Endocrine Neoplasia Ii	Men2 Syndrome
Men-2a Syndrome	Multiple Neoplasia 2a
Multiple Neoplasia Type 2

Leiomyomatosis

Fumarate Hydratase Deficiency

Fumarase Deficiency

Fumaric Aciduria

Pancreatic Serous Cystadenoma

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Neurofibromatosis

Neurofibromatoses	Acoustic Neurofibromatosis
Central Neurofibromatosis	Peripheral Neurofibromatosis
Recklinghausen'S Neurofibromatosis	Von Reklinghausen Disease
Neurofibromatosis Type 1

Oncocytoma

Oxyphilic Adenoma	Follicular Adenoma, Oxyphilic Cell
Adenoma, Oxyphilic	Hurthle Cell Tumor
Oncocytic Neoplasm

Neurofibromatosis, Type I

Von Recklinghausen Disease	Neurofibromatosis 1
Neurofibromatosis, Type 1	NF1
Neurofibromatosis, Peripheral Type	Neurofibromatosis Type I
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion	Familial Spinal Neurofibromatosis
Fsnf	Peripheral Neurofibromatosis
Von Recklinghausen'S Neurofibromatosis	Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion
Neurofibromatosis Peripheral Type	Von Recklinghausen Syndrome
Neurofibromatosis Type 1	Von Recklinghausen Neuropathy
Nf1 - [Neurofibromatosis Type 1]	Recklinghausen Disease

Central Nervous System Hemangioma

Hemangioma Of Cns

Hemangioma Of The Central Nervous System

Cardiovascular Organ Benign Neoplasm

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma	Familial Medullary Thyroid Carcinoma
MTC	Medullary Thyroid Cancer
Fmtc	Mtc1
Thyroid Cancer, Medullary	Thyroid Carcinoma, Medullary
Familial Mtc	Thyroid Carcinoma Medullary
Carcinoma, Thyroid, Medullary, Familial	Medullary Carcinoma Of Thyroid
Medullary Carcinoma With Amyloid Stroma, Unspecified Site	Medullary Carcinoma With Amyloid Stroma Of Thyroid

Hemangioma

Hemangiomas

Middle Ear Adenocarcinoma

Adenocarcinoma Of Middle Ear

Adenocarcinoma Of The Middle Ear

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Hereditary Renal Cell Carcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13001	Quizartinib		99.01%	Yes
HY-14217	Quizartinib dihydrochloride		99.81%	Yes

Pre-clinical Phase

Bioactive Molecules (276)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100947	VH-298	Inhibitor	99.78%	Unkown
HY-130604	DT2216		99.97%	Unkown
HY-120217	VH032		99.64%	Unkown
HY-42424	(S,R,S)-AHPC-Me hydrochloride		99.59%	Unkown
HY-137516	LC-2	Inhibitor	98.04%	Unkown
HY-111997	VH285-PEG4-C4-Cl		≥98.0%	Unkown
HY-101763A	(S,R,S)-AHPC monohydrochloride		99.83%	Unkown
HY-18728	STF-31		99.79%	Unkown
HY-130492	ARCC-4	Inhibitor	99.88%	Unkown
HY-125845	(S,R,S)-AHPC		99.13%	Unkown
HY-132296	GSK215	Inhibitor	99.85%	Unkown
HY-145479	PROTAC AR-V7 degrader-1	Inhibitor	99.34%	Unkown
HY-151623	ACBI2	Inhibitor	99.76%	Unkown
HY-148030	XL01126	Inhibitor	99.81%	Unkown
HY-119932	PROTAC FAK degrader 1	Inhibitor	99.25%	Unkown
HY-125878	PROTAC SGK3 degrader-1	Inhibitor	99.89%	Unkown
HY-130602	MS432	Inhibitor	99.78%	Unkown
HY-112078	(S,R,S)-AHPC-Me		99.48%	Unkown
HY-130257	CP5V	Inhibitor	99.31%	Unkown
HY-103601	(S,R,S)-AHPC-PEG4-N3		99.93%	Unkown
HY-113491	3-Phosphoglyceric acid		99.78%	Unkown
HY-130271	(S,R,S)-AHPC-PEG5-COOH		99.80%	Unkown
HY-103598	(S,R,S)-AHPC-PEG3-N3		99.67%	Unkown
HY-153863	MS934	Degrader	98.82%	Unkown
HY-129937A	GNE-987	Inhibitor	99.91%	Unkown
HY-44432	Navitoclax-piperazine	Inhibitor	99.73%	Unkown
HY-153188	JNJ-1013		99.80%	Unkown
HY-125905	VH032-cyclopropane-F		99.92%	Unkown
HY-136262	CRBN-6-5-5-VHL		99.98%	Unkown
HY-112495	VH032-PEG5-C6-Cl		99.93%	Unkown
HY-103602	(S,R,S)-AHPC-PEG3-NH2 hydrochloride		99.01%	Unkown
HY-125834	GMB-475		98.98%	Unkown
HY-128845	PROTAC CRBN Degrader-1		99.84%	Unkown
HY-145162	SHP2-D26	Inhibitor	95.03%	Unkown
HY-141438	SIM1	Inhibitor	99.57%	Unkown
HY-103600	(S,R,S)-AHPC-PEG1-N3		98.18%	Unkown
HY-125845A	(S,S,S)-AHPC hydrochloride		99.42%	Unkown
HY-138669	C004019	Degrader	99.37%	Unkown
HY-133737	PROTAC BRD4 Degrader-5	Inhibitor	99.93%	Unkown
HY-100746	STF-62247	Inducer	98.99%	Unkown
HY-145816A	JPS016 TFA		98.70%	Unkown
HY-103604A	(S,R,S)-AHPC-PEG4-NH2		99.51%	Unkown
HY-103603	(S,R,S)-AHPC-PEG2-NH2 hydrochloride		99.77%	Unkown
HY-103599	(S,R,S)-AHPC-PEG2-N3		99.74%	Unkown
HY-126456	(S,R,S)-AHPC-propargyl		99.48%	Unkown
HY-132857A	ZXH-4-130 TFA		99.71%	Unkown
HY-153119	TMX-4153		98.96%	Unkown
HY-128756	SIAIS178	Inhibitor	99.36%	Unkown
HY-128767	VH032-PEG3-acetylene		98.14%	Unkown
HY-130979	EED226-COOH		98.53%	Unkown
HY-111663	VL285		98.84%	Unkown
HY-130815A	MAK683-CH2CH2COOH hydrochloride	Inhibitor	98.03%	Unkown
HY-133045	VHL Ligand 8		98.04%	Unkown
HY-47070	VH 101, acid		98.37%	Unkown
HY-B2171A	Carubicin hydrochloride	Inducer	98.33%	Unkown
HY-130798	(S,R,S)-AHPC-amido-C5-acid		99.58%	Unkown
HY-156106	VHL-IN-1		99.78%	Unkown
HY-111905	BRD7-IN-1	Inhibitor	99.77%	Unkown
HY-148896	(S,R,S)-AHPC-C2-PEG3-BCN		≥98.0%	Unkown
HY-103605	(S,R,S)-AHPC-C6-PEG3-C4-Cl		97.01%	Unkown
HY-137346	DD-03-156	Degrader	99.63%	Unkown
HY-139218	(S,R,S)-AHPC-Me-C6-NH2		99.14%	Unkown
HY-130714	TD-165	Inhibitor	99.41%	Unkown
HY-103607	(S,R,S)-AHPC-PEG2-C4-Cl		98.21%	Unkown
HY-148671	(S,R,S)-AHPC-amido-C7-acid		98.28%	Unkown
HY-123109	(S,R,S)-AHPC-Boc		95.21%	Unkown
HY-103604	(S,R,S)-AHPC-PEG4-NH2 hydrochloride		98.06%	Unkown
HY-114323	PROTAC FLT-3 degrader 1		99.74%	Unkown
HY-133487B	(S,R,S)-AHPC-C8-NH2		97.04%	Unkown
HY-136163	(S,R,S)-AHPC-C2-NH2 dihydrochloride		98.63%	Unkown
HY-130845A	AR antagonist 1 hydrochloride	Antagonist	99.53%	Unkown
HY-131388	ABM-14		98.17%	Unkown
HY-152154	Nampt degrader-2		99.41%	Unkown
HY-42424A	(S,R,S)-AHPC-Me dihydrochloride		99.84%	Unkown
HY-131865	SJF-1521	Degrader	99.65%	Unkown
HY-130849	(S,R,S)-AHPC-Me-C5-COOH		96.87%	Unkown
HY-103608	(S,R,S)-AHPC-(C3-PEG)2-C6-Cl		99.89%	Unkown
HY-130711B	(S,R,S)-AHPC-C3-NH2 hydrochloride		96.38%	Unkown
HY-145815A	JPS014 TFA		98.40%	Unkown
HY-150803	VHL Ligand 14		99.93%	Unkown
HY-47851	VH 101, thiol		98.66%	Unkown
HY-145264	OARV-771	Inhibitor	98.33%	Unkown
HY-162362	MS8709	Degrader	98.91%	Unkown
HY-114176B	(S,R,S)-AHPC-C4-NH2 dihydrochloride		/	Unkown
HY-130991	K-Ras ligand-Linker Conjugate 6		/	Unkown
HY-131387	(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2		96.12%	Unkown
HY-136183	(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride		98.16%	Unkown
HY-136184	(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride		99.01%	Unkown
HY-122702	PEG6-(CH2CO2H)2		≥95.0%	Unkown
HY-123109A	(S,S,S)-AHPC-Boc		97.21%	Unkown
HY-130716	Thalidomide-NH-C10-COOH	Inducer	97.50%	Unkown
HY-131295	PD0325901-O-C2-dioxolane	Inhibitor	98.76%	Unkown
HY-131866	(S,R,S)-CO-C2-acid		≥98.0%	Unkown
HY-136006B	(S,R,S)-AHPC-C6-NH2		98.03%	Unkown
HY-136257	CMP98		99.72%	Unkown
HY-138550A	(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA		99.42%	Unkown
HY-138678	(R,S,S)-VH032		≥95.0%	Unkown
HY-141797	MS33	Inhibitor	/	Unkown
HY-151227	VL285 Phenol		98.56%	Unkown
HY-156152A	CARM1 degrader-1 hydrochloride	Degrader	/	Unkown
HY-156568A	SMD-3040 TFA	Degrader	99.90%	Unkown
HY-158142	PROTAC TYK2 degrader-1	Degrader	/	Unkown
HY-162250	MS8847	Inhibitor	/	Unkown
HY-162608	PROTAC JAK1 degrader 1	Degrader	/	Unkown
HY-163897	PROTAC NCOA4 degrader-1	Inhibitor	/	Unkown
HY-130815	MAK683-CH2CH2COOH	Inhibitor	/	Unkown
HY-131959	(S,R,S)-AHPC-PEG5-Boc		95.29%	Unkown
HY-136165	(S,R,S)-AHPC-PEG3-propionic acid		97.03%	Unkown
HY-155815	MS9715	Inhibitor	/	Unkown
HY-103602A	(S,R,S)-AHPC-PEG3-NH2		99.26%	Unkown
HY-103603A	(S,R,S)-AHPC-PEG2-NH2		95.41%	Unkown
HY-103603B	(S,R,S)-AHPC-PEG2-NH2 dihydrochloride		≥95.0%	Unkown
HY-130642	(S,R,S)-AHPC-Me-C10-Br		97.21%	Unkown
HY-130707	K-Ras ligand-Linker Conjugate 3		/	Unkown
HY-130816	(S,R,S)-AHPC-O-Ph-PEG1-NH2		96.97%	Unkown
HY-130823	K-Ras ligand-Linker Conjugate 5		96.96%	Unkown
HY-133487A	(S,R,S)-AHPC-C8-NH2 hydrochloride		/	Unkown
HY-136006A	(S,R,S)-AHPC-C6-NH2 hydrochloride		/	Unkown
HY-136164	VH032-OH		99.43%	Unkown
HY-103606	(S,R,S)-AHPC-PEG6-C4-Cl		96.24%	Unkown
HY-111823	VH032 thiol		95.91%	Unkown
HY-114176	(S,R,S)-AHPC-C4-NH2 hydrochloride		≥97.0%	Unkown
HY-138862	(S,R,S)-AHPC-C1-Br		≥98.0%	Unkown
HY-156568	SMD-3040	Degrader	99.91%	Unkown
HY-110402	(S,R,S)-AHPC TFA		/	Unkown
HY-111905A	BRD7-IN-1 free base	Inhibitor	/	Unkown
HY-129775	K-Ras ligand-Linker Conjugate 1		/	Unkown
HY-129776	K-Ras ligand-Linker Conjugate 2		/	Unkown
HY-129941	(S,R,S)-AHPC-C10-NH2		/	Unkown
HY-130711A	(S,R,S)-AHPC-C3-NH2 TFA		/	Unkown
HY-130845	AR antagonist 1		/	Unkown
HY-141486	(Rac)-PROTAC PARP/EGFR ligand 1		/	Unkown
HY-156744	DBr-1	Degrader	/	Unkown
HY-159147	SIAIS039		/	Unkown
HY-168555	YJ1206		/	Unkown
HY-114176A	(S,R,S)-AHPC-C4-NH2		/	Unkown
HY-125846	(S,R,S)-AHPC-PEG1-OTs		/	Unkown
HY-125906	VHL Ligand-Linker Conjugates 15		/	Unkown
HY-129941A	(S,R,S)-AHPC-C10-NH2 dihydrochloride		/	Unkown
HY-130711	(S,R,S)-AHPC-C3-NH2		/	Unkown
HY-130822	K-Ras ligand-Linker Conjugate 4		98.76%	Unkown
HY-130847	(S,R,S)-AHPC-Me-C10-NH2		96.19%	Unkown
HY-133487	(S,R,S)-AHPC-C8-NH2 dihydrochloride		/	Unkown
HY-136006	(S,R,S)-AHPC-C6-NH2 dihydrochloride		/	Unkown
HY-136008A	(S,R,S)-AHPC-PEG1-NH2 dihydrochloride		/	Unkown
HY-136055	(S,R,S)-AHPC-C5-COOH	Inhibitor	98.81%	Unkown
HY-156730	KT-333	Degrader	/	Unkown
HY-156730B	KT-333 diammonium	Degrader	/	Unkown
HY-100947A	cis VH-298		/	Unkown
HY-101763B	(S,R,S)-AHPC dihydrochloride		/	Unkown
HY-103602B	(S,R,S)-AHPC-PEG3-NH2 dihydrochloride		/	Unkown
HY-111824	VH032-thiol-C6-NH2		/	Unkown
HY-112078A	(S,R,S,R)-AHPC-Me		/	Unkown
HY-114322A	cis-VZ185	Degrader	/	Unkown
HY-130641	Br-C10-methyl ester		97.87%	Unkown
HY-130654	(S,R,S)-AHPC-C2-PEG4-N3		/	Unkown
HY-130711C	(S,R,S)-AHPC-C3-NH2 dihydrochloride		/	Unkown
HY-131168	(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH		99.31%	Unkown
HY-132857	ZXH-4-130		/	Unkown
HY-133046	VHL Ligand-Linker Conjugates 17		/	Unkown
HY-136005	VH032-C7-COOH		/	Unkown
HY-136008	(S,R,S)-AHPC-PEG1-NH2		/	Unkown
HY-136163A	(S,R,S)-AHPC-C2-NH2		/	Unkown
HY-136186	(S,R,S)-AHPC-C7-amine		/	Unkown
HY-136186B	(S,R,S)-AHPC-C7-amine hydrochloride		/	Unkown
HY-136187	(S,R,S)-AHPC-C5-NH2		/	Unkown
HY-136187A	(S,R,S)-AHPC-C5-NH2 dihydrochloride		/	Unkown
HY-137516A	LC-2 epimer		/	Unkown
HY-138678B	(S,R,R)-VH032		/	Unkown
HY-138861	(S,R,S)-AHPC-C1-NH2		/	Unkown
HY-138861A	(S,R,S)-AHPC-C1-NH2 hydrochloride		98.08%	Unkown
HY-139335	VH 101 phenol-alkylC4-amine dihydrochloride		/	Unkown
HY-141651	(S,R,S)-AHPC-C3-COOH		/	Unkown
HY-144323	YF135	Inhibitor	/	Unkown
HY-145514B	dTAGV-1-NEG TFA		/	Unkown
HY-145715	Azido-PEG2-VHL		/	Unkown
HY-145815	JPS014		/	Unkown
HY-145816	JPS016		/	Unkown
HY-145818	JPS035		/	Unkown
HY-145819	JPS036		/	Unkown
HY-146022	SIAIS117	Inhibitor	/	Unkown
HY-147174	PROTAC_ERRα	Inhibitor	99.71%	Unkown
HY-147235	RIPK2-IN-2	Inhibitor	/	Unkown
HY-147373	DA-PROTAC		/	Unkown
HY-148406	(S,R,S)-AHPC-C10-NHBoc		98.32%	Unkown
HY-155356	YN14	Degrader	/	Unkown
HY-155506	NAMPT degrader-3	Degrader	/	Unkown
HY-155643	PROTAC TG2 degrader-1	Inhibitor	/	Unkown
HY-156152	CARM1 degrader-1	Inhibitor	/	Unkown
HY-156153	CARM1 degrader-2	Inhibitor	/	Unkown
HY-156730A	KT-333 ammonium	Degrader	/	Unkown
HY-157590	E3 ligase Ligand-Linker Conjugate 32		/	Unkown
HY-157593	E3 ligase Ligand-Linker Conjugate 35		/	Unkown
HY-157596	E3 ligase Ligand-Linker Conjugate 40		/	Unkown
HY-157597	E3 ligase Ligand-Linker Conjugate 42		/	Unkown
HY-157598	E3 ligase Ligand-Linker Conjugate 46		/	Unkown
HY-157634	E3 Ligase Ligand-linker Conjugate 91		/	Unkown
HY-157752	E3 Ligase Ligand-linker Conjugate 101		/	Unkown
HY-157753	E3 Ligase Ligand-linker Conjugate 102		/	Unkown
HY-157754	E3 Ligase Ligand-linker Conjugate 103		/	Unkown
HY-158036	PROTAC STING Degrader-2	Degrader	/	Unkown
HY-158046	UNC8899	Degrader	/	Unkown
HY-158047	UNC8900	Degrader	/	Unkown
HY-158048	UNC9036	Degrader	/	Unkown
HY-158345	PROTAC VHL-type degrader-1		/	Unkown
HY-158429	PROTAC CYP1B1 degrader-2	Degrader	/	Unkown
HY-158684	YX-02-030	Degrader	/	Unkown
HY-158685	RG7112D	MDM2 Inhibitor	/	Unkown
HY-159175	XM-U-14		/	Unkown
HY-159457	PROTAC SMARCA2/4-degrader-6	Degrader	/	Unkown
HY-160555	(S,R,S)-AHPC-CO-C9-NH2		/	Unkown
HY-160555A	(S,R,S)-AHPC-CO-C9-NH2 hydrochloride		98.79%	Unkown
HY-160924	MS147	Inhibitor	/	Unkown
HY-161132	Lenalidomide 4'-alkyl-C5-azide		/	Unkown
HY-161194	(S,R,S)-AHPC-acetyl-azetidine-PIP-boc		/	Unkown
HY-161207	(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc		/	Unkown
HY-161367	VHL-SF2		/	Unkown
HY-161368	BRD-SF2	Degrader	/	Unkown
HY-161445	(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH		/	Unkown
HY-162193	E3 Ligase Ligand-linker Conjugate 27		/	Unkown
HY-162202	E3 Ligase Ligand-linker Conjugate 50		/	Unkown
HY-162450	Antitumor agent-150		/	Unkown
HY-162538	LC-MI-3		/	Unkown
HY-162553	GNE7599		/	Unkown
HY-162834	PROTAC SMARCA2/4-degrader-27	Degrader	/	Unkown
HY-162835	PROTAC SMARCA2/4-degrader-28	Degrader	/	Unkown
HY-162943	P60-L3-VHL		/	Unkown
HY-162947	2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid		/	Unkown
HY-163209	VH 032 amide-PEG6-amine hydrochloride		/	Unkown
HY-163215	(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163216	PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163217	PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc		/	Unkown
HY-163219	VHL Ligand 8-PEG2-O-piperidine-Boc		/	Unkown
HY-163220	(S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc		/	Unkown
HY-163223	(S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc		/	Unkown
HY-163224	(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-163228	PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-163231	(S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH		/	Unkown
HY-163440	PROTAC NAMPT Degrader-1	Degrader	/	Unkown
HY-163845	YX862	Degrader	/	Unkown
HY-163872	PROTAC SMARCA2/4-degrader-10	Degrader	/	Unkown
HY-168026	CEP1347-VHL-02		/	Unkown
HY-168027	CEP-1347-acid		/	Unkown
HY-168229	PROTAC SMARCA2 degrader-27	Degrader	/	Unkown
HY-168234	PROTAC SMARCA2 degrader-31	Inhibitor	/	Unkown
HY-169093	MS41		/	Unkown
HY-169264	SJYHJ-026		/	Unkown
HY-44630	VH 032 amide-alkylC6-acid		/	Unkown
HY-B2171	Carubicin	Inducer	/	Unkown
HY-P5915	FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2	Agonist	/	Unkown
HY-RS15648	VHL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W584525	VH032-NH-CO-CH2-NHBoc		/	Unkown
HY-W584527	VH032 analogue-1		/	Unkown
HY-W584528	VH032 analogue-2		/	Unkown
HY-W584529	VH032-C2-NH-Boc		/	Unkown
HY-W584530	VH032-C4-NH-Boc		/	Unkown
HY-W584531	VH032-C6-NH-Boc		/	Unkown
HY-W584532	VH032-O-C2-NH-Boc		/	Unkown
HY-W584533	VH032-PEG2-NH-BOC		/	Unkown
HY-W584534	VH032-CH2-Boc		/	Unkown
HY-W584535	VH032-C3-Boc		/	Unkown
HY-131890	VH032 amide-PEG1-acid		/	Unkown
HY-135045	(S,R,S)-AHPC-C4-COOH		/	Unkown
HY-136186A	(S,R,S)-AHPC-C7-amine dihydrochloride		/	Unkown
HY-139334	VH 101 phenol-alkylC6-amine dihydrochloride		/	Unkown
HY-139341	Pomalidomide 4'-alkylC3-azide		/	Unkown
HY-139343	Pomalidomide 4'-alkylC2-azide		/	Unkown
HY-157512	SJF-0661		/	Unkown
HY-162930	PROTAC METTL3 degrader 1	Degrader	/	Unkown
HY-164043	(S,R,S)-AHPC(Me)-amido-C2-acid		/	Unkown
HY-168288	MEK ligand-2	Inhibitor	/	Unkown
HY-168290	(S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide		/	Unkown
HY-400685	SMD-3040 intermediate-2		95.82%	Unkown
HY-49514	SOS1 Ligand intermediate-1		/	Unkown
HY-49515	SOS1 Ligand intermediate-2		/	Unkown
HY-D2413	BODIPY FL VH032		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VHL	VGNC	VGNC:97325
Rattus norvegicus	VHL	RGD	RGD:3960
Mus musculus	VHL	MGD	MGI:103223
Others	VHL	NCBI