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Endoplasmic Reticulum Oxidoreductase 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (2) ER-phagy (1) PERK (5) 5 alpha Reductase (1) 5-HT Receptor (1) ADC Cytotoxin (1) Akt (3) Aminopeptidase (4) Aminotransferases (Transaminases) (1) AMPK (3) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (6) Apoptosis (71) ATF6 (2) Autophagy (23) Bacterial (12) Bcl-2 Family (2) Biochemical Assay Reagents (9) BRK (1) Calcium Channel (32) Caspase (15) CDK (1) CDKL (1) CETP (1) CFTR (1) CRISPR/Cas9 (2) Cytochrome P450 (5) Dengue Virus (1) Deubiquitinase (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (1) Drug Intermediate (1) Drug Metabolite (3) DYRK (1) E1/E2/E3 Enzyme (3) EGFR (1) Endogenous Metabolite (40) Epoxide Hydrolase (1) ERK (9) Estrogen Receptor/ERR (3) Eukaryotic Initiation Factor (eIF) (1) Ferroptosis (7) Flavivirus (1) Fluorescent Dye (14) Formyl Peptide Receptor (FPR) (2) Free Fatty Acid Receptor (1) Fungal (3) Glycosidase (5) GSK-3 (1) HDAC (7) Histone Demethylase (1) HIV (7) HSP (4) HSV (2) IKZF Family (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (2) IRE1 (10) Isotope-Labeled Compounds (11) JNK (3) Keap1-Nrf2 (3) Lactate Dehydrogenase (2) LDLR (1) Lipase (1) Liposome (1) MDM-2/p53 (2) Melatonin Receptor (4) Microtubule/Tubulin (4) Mitochondrial Metabolism (12) Mitophagy (6) MMP (2) mTOR (2) Myosin (1) Na+/K+ ATPase (3) NADPH Oxidase (1) NF-κB (8) p38 MAPK (3) p97 (2) Paraptosis (1) Parasite (11) PD-1/PD-L1 (1) PDGFR (1) PDHK (1) PDI (1) Peptide-Drug Conjugates (PDCs) (1) Phosphodiesterase (PDE) (1) Phospholipase (1) Photosensitizer (2) PI3K (1) PKC (1) Porcupine (1) Potassium Channel (2) PROTACs (1) Proton Pump (1) PSMA (1) Pyroptosis (1) Quinone Reductase (2) Reactive Oxygen Species (19) RSV (1) SARS-CoV (2) SGK (1) SOD (1) Sodium Channel (1) STAT (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) TRP Channel (3) TrxR (3) URAT1 (1) Virus Protease (4) Xanthine Oxidase (13) Zinc Finger Protein (1) β-catenin (1)
By Research Areas:	Cancer (129) Cardiovascular Disease (25) Endocrinology (7) Infection (40) Inflammation/Immunology (30) Metabolic Disease (53) Neurological Disease (45)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Antioxidants (1) Phospholipids (1)

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Targets Recommended: Endoplasmic Reticulum Oxidoreductase 1 (ERO1) PERK ER-phagy

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136213

Endoplasmic reticulum dye 1	Fluorescent Dye	Others
Endoplasmic reticulum dye 1 is a promising live cell imaging agent for the detection of exocytotic events at the plasma membrane. Endoplasmic reticulum dye 1 shows low cytotoxicity, resistance to photobleaching , which is ideal for imaging either short- or long-time courses ^[1].

HY-148520

QM295	Endoplasmic Reticulum Oxidoreductase 1 (ERO1)	Metabolic Disease
QM295 is an **endoplasmic reticulum oxidation 1 (ERO1)** inhibitor with selectively reversible thiol reactivity. QM295 can be used for the research of endoplasmic reticulum stress ^[1].

HY-D2299

AIE-ER	Fluorescent Dye	Metabolic Disease Cancer
AIE-ER is a specific endoplasmic reticulum (ER) fluorescent probe (green channel: λ_ex=405 nm, λ_em=450~650 nm) that exhibits remarkable photostability, high brightness, and low working concentration. AIE-ER may provide an avenue for studying diseases related to the endoplasmic reticulum ^[1].

HY-137813

PERK-IN-4	PERK	Neurological Disease Metabolic Disease Cancer
PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC ₅₀ of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states ^[1].

HY-D1297

ER-Tracker Green 1 Publications Verification	Fluorescent Dye	Others
ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation ^[1].

HY-133125

ERAP1-IN-1 2 Publications Verification	Aminopeptidase	Inflammation/Immunology
ERAP1-IN-1 is an **endoplasmic reticulum aminopeptidase 1 (ERAP1)** inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates ^[1].

HY-151974

*Xanthine oxidoreductase-IN-4*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-4 is an orally active *xanthine oxidoreductase* (XOR)** inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC₅₀ value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia ^[1].

HY-151975

*Xanthine oxidoreductase-IN-5*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-5 is an orally active *xanthine oxidoreductase* (XOR) inhibitor, with an IC₅₀** of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia ^[1].

HY-151973

*Xanthine oxidoreductase-IN-3*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-3 is an orally active *xanthine oxidoreductase* (XOR) inhibitor, with an IC₅₀** of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia ^[1].

HY-146297

*Xanthine oxidoreductase-IN-2*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidoreductase-IN-2 (Compound IVa) is a xanthine oxidoreductase (XOR) inhibitor with the IC₅₀ of 7.2 nM. Xanthine oxidoreductase-IN-2 shows hypouricemic effects in mice ^[1].

HY-N7214

Termitomycamide E	Others	Neurological Disease
Termitomycamide E is a fatty acid amide that can suppress endoplasmic reticulum stress. Termitomycamide E shows significant protective activity against T. titanicus-toxicity ^[1].

HY-169957

ROS-ERS inducer 2	Reactive Oxygen Species	Cancer
ROS-ERS inducer 2 (Complex 3f) triggers intracellular ROS generation and affect the function of mitochondria. promote the release of damage-associated molecular patterns (DAMPs), induce immunogenic cell death (ICD) and activates endoplasmic reticulum stress (ERS). ROS-ERS inducer 2 plays an important role in anti-liver cancer research ^[1].

HY-134261

8-Br-ADPR 8-Bromoadenosine-5'-O-diphosphoribose	TRP Channel	Metabolic Disease
8-Br-ADPR (8-Bromoadenosine-5'-O-diphosphoribose), an analogue of Adenosine 5′-diphosphoribose (HY-100973), is a TRPM2 modulator. 8-Br-ADPR is a human TRPM2 (hsTRPM2) inhibitor and a Nematostella vectensis (nvTRPM2) partial agonist (EC₅₀ of 31.9 µM). 8-Br-ADPR regulates calcium release from the endoplasmic reticulum and sarcoplasmic reticulum ^[1].

HY-129348

IRE1α kinase-IN-10	IRE1	Cancer
IRE1α kinase-IN-10 (GP29) is an IRE1α kinase inhibitor. IRE1α kinase-IN-10 can be used for the research of endoplasmic reticulum stress-related diseases ^[1].

HY-152240

PD-1/PD-L1-IN-29	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN-29 (S4-1) is a potent *PD-1/PD-L1* inhibitor with an IC₅₀ value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity ^[1].

HY-P10738A

N-Formyl-MMYALF TFA	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF TFA can inhibit the *FPR-1*-mediated chemotactic response of PMNs to bacterial peptides ^[1].

HY-19696

Tauroursodeoxycholate 70+ Cited Publications Tauroursodeoxycholic acid; TUDCA; UR 906	ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-P10738

N-Formyl-MMYALF	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the *FPR-1*-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides ^[1].

HY-19696A

Tauroursodeoxycholate sodium 70+ Cited Publications Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium	ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N0878

Bufotalin 4 Publications Verification	Apoptosis Reactive Oxygen Species	Cancer
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation ^[1] .

HY-D1429

ER-Tracker Blue-White DPX	Fluorescent Dye	Others
ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation ^[1].

HY-124735

RH01687	Apoptosis	Metabolic Disease
RH01687 is a compound that can protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. RH01687 has the potential for the research of diabetes ^[1].

HY-19696B

Tauroursodeoxycholate dihydrate 70+ Cited Publications Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	ERK Caspase Apoptosis Endogenous Metabolite	Cancer
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK ^[1] .

HY-19696R

Tauroursodeoxycholate (Standard)	ERK Caspase Endogenous Metabolite Apoptosis	Cancer
Tauroursodeoxycholate (Standard) is the analytical standard of Tauroursodeoxycholate. This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-D1687

Flubi-2	Fluorescent Dye	Others
Flubi-2 is a fluorescein-biotin based pH-ratio dye (Ex=480 nm, Em= 520-560 nm) with a pK value of 6.7. Flubi-2 is a hydrolysis product of Flubida-2 (non-fluorescent, membrane permeable). Flubi-2 can be used for pH determination of organelles of the secretory pathway (such as golgi apparatus and endoplasmic reticulum) in living cells ^[1] .

HY-125603

Termitomycamide B	Free Fatty Acid Receptor	Neurological Disease
Termitomycamide B (compound 2) is a neuroprotective agent that can be obtained from Termitomyces titanicus. Termitomycamide B effectively inhibits endoplasmic reticulum stress-dependent cell death. Termitomycamide B can be used in the study of neurodegenerative diseases ^[1] .

HY-N7395

Cyclic ADP-ribose cADPR	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels ^[1] .

HY-N7395A

Cyclic ADP-ribose ammonium cADPR ammonium	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels ^[1] .

HY-Y0152A

Cinchonine monohydrochloride hydrate (8R,9S)-Cinchonine monohydrochloride hydrate; LA40221 monohydrochloride hydrate	Parasite Apoptosis	Infection Cardiovascular Disease Metabolic Disease Cancer
Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as antimalarial agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis ^[1].

HY-145001

20-HC-Me-Pyrrolidine	LDLR CETP	Metabolic Disease
20-HC-Me-Pyrrolidine is a potent Aster protein inhibitor with IC₅₀s of 0.11 μM, 0.06 μM, and 0.71 μM for Aster-A, Aster-B, and Aster-C, respectively. 20-HC-Me-Pyrrolidine blocks the ability of Asters to bind and transfer cholesterol. 20-HC-Me-Pyrrolidine also inhibits the movement of low-density lipoprotein (LDL) cholesterol to the endoplasmic reticulum (ER) ^[1].

HY-153202

SLMP53-2	MDM-2/p53 Apoptosis	Cancer
SLMP53-2 is a mutant p53 reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity ^[1] .

HY-138364

YUM70 2 Publications Verification	HSP Apoptosis	Cancer
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC₅₀ of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model ^[1].

HY-111974

β-D-Glucopyranosyl abscisate ABA-GE; (S)-cis,trans-Abscisic acid glucosyl ester	Proton Pump	Endocrinology
β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable abscisic acid (ABA) conjugate that accumulates in the vacuole and presumably also in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate allows the rapid formation of free ABA in response to abiotic stress conditions such as dehydration and salt stress. β-D-Glucopyranosyl abscisate contributes to the maintenance of ABA homeostasis ^[1].

HY-146696

mEH-IN-1	Epoxide Hydrolase	Cardiovascular Disease Neurological Disease Cancer
mEH-IN-1 (Compound 62) is a potent microsomal epoxide hydrolase (mEH) inhibitor with the IC₅₀ of 2.2 nM. The mEH is a mammalian α/β-fold hydrolase enzyme, expressed in almost all tissues, hydrolyzes a wide range of epoxide containing molecules. The mEH is mainly localized in the endoplasmic reticulum (ER) of eukaryotic cells. mEH-IN-1 can be used for the research of preeclampsia, hypercholanemia and cancer ^[1].

HY-110078

Eeyarestatin I 5 Publications Verification	p97 Apoptosis	Cancer
Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects ^[1] .

HY-N1487

Oleanonic acid 1 Publications Verification 3-Oxooleanolic acid	HIV Autophagy Ferroptosis Amyloid-β	Infection Neurological Disease Inflammation/Immunology Cancer
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats ^[1] .

HY-146296

*Xanthine oxidoreductase-IN-1*	Xanthine Oxidase	Metabolic Disease
The compound is a xanthine oxidoreductase (XOR) inhibitor with high inhibitory concentration, and the value of ic₅₀ is 7.0 nm.

HY-157158

TrxR-IN-6	TrxR Apoptosis	Cancer
TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces reactive oxygen species (ROS) accumulation and has anticancer activity. TrxR-IN-6 can further lead to redox system collapse, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Finally, it causes oxidative stress and induces apoptosis ^[1].

HY-135887

ZX-29	Anaplastic lymphoma kinase (ALK) Apoptosis Autophagy	Cancer
ZX-29 is a potent and selective ALK inhibitor with an IC₅₀ of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect ^[1].

HY-N10661

Ipomoeassin F Ipom-F	SARS-CoV	Infection Cancer
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs ^[1] .

HY-124662

IHVR-19029	Flavivirus Dengue Virus Glycosidase	Infection
IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC₅₀ of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir (HY-14768) improves the antiviral efficacy ^[1] .

HY-169842

NSC 645827	Quinone Reductase	Cancer
NSC 645827 is an inhibitor for NAD(P)H: quinone oxidoreductase 1 (NQO1) with an IC₅₀ of 0.7 μM ^[1].

HY-N0492

α-Lipoic Acid 5+ Cited Publications Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent *HIV-1* LTR activation ^[1] . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium 5+ Cited Publications Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent *HIV-1* LTR activation ^[1] . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-P10326

Z-ATAD-FMK	Caspase Apoptosis	Cancer
Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK prevents endoplasmic reticulum stress-mediated apoptosis by inhibiting the activity of caspase-12 and reducing the activity of caspase-9 ^[1].

HY-149769

CP-506	Cytochrome P450	Cancer
CP-506 (compound 26) is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity ^[1].

HY-157231A

HC-5404-Fu	PERK	Cancer
HC-5404-Fu is a PERK inhibitor with an antitumor activity. HC-5404-Fu inhibits endoplasmic reticulum stress response signalling. HC-5404-Fu sensitizes renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). HC-5404-Fu is promising for research of renal cell carcinoma, gastric cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors ^[1] .

HY-139704

Eroonazole	Biochemical Assay Reagents	Others
Eroonazole is a new small molecule disrupter of endoplasmic reticulum structure.

HY-N0645

Dicoumarol 5+ Cited Publications Dicumarol	PDHK	Cancer
Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and *PDK1* with IC₅₀s of 0.37 and 19.42 μM, respectively.

HY-124873

SERCA2a activator 1	Calcium Channel	Cardiovascular Disease
SERCA2a activator 1 (Compound A) is a *sarco/endoplasmic* reticulum Ca ²⁺-dependent ATPase 2a (SERCA2a)** activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-19696

Tauroursodeoxycholate 70+ Cited Publications Tauroursodeoxycholic acid; TUDCA; UR 906	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696A

Tauroursodeoxycholate sodium 70+ Cited Publications Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N0878

Bufotalin 4 Publications Verification	Structural Classification Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	Apoptosis Reactive Oxygen Species
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation ^[1] .

HY-19696B

Tauroursodeoxycholate dihydrate 70+ Cited Publications Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK ^[1] .

HY-N7395

Cyclic ADP-ribose cADPR	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels ^[1] .

HY-N7395A

Cyclic ADP-ribose ammonium cADPR ammonium	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels ^[1] .

HY-N7214

Termitomycamide E	Structural Classification Monophenols Microorganisms Source classification Phenols	Others
Termitomycamide E is a fatty acid amide that can suppress endoplasmic reticulum stress. Termitomycamide E shows significant protective activity against T. titanicus-toxicity ^[1].

HY-19696R

Tauroursodeoxycholate (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate (Standard) is the analytical standard of Tauroursodeoxycholate. This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-125603

Termitomycamide B	Structural Classification Natural Products Microorganisms Source classification	Free Fatty Acid Receptor
Termitomycamide B (compound 2) is a neuroprotective agent that can be obtained from Termitomyces titanicus. Termitomycamide B effectively inhibits endoplasmic reticulum stress-dependent cell death. Termitomycamide B can be used in the study of neurodegenerative diseases ^[1] .

HY-Y0152A

Cinchonine monohydrochloride hydrate (8R,9S)-Cinchonine monohydrochloride hydrate; LA40221 monohydrochloride hydrate	Cardiovascular Disease Infection Cinchona succirubra Pav. ex Klotzsch Alkaloids Classification of Application Fields Source classification Rubiaceae Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields	Parasite Apoptosis
Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as antimalarial agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis ^[1].

HY-111974

β-D-Glucopyranosyl abscisate ABA-GE; (S)-cis,trans-Abscisic acid glucosyl ester	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Abscisic acid Plants Phytohormone Disease Research Fields Endocrinology Agricultural Research	Proton Pump
β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable abscisic acid (ABA) conjugate that accumulates in the vacuole and presumably also in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate allows the rapid formation of free ABA in response to abiotic stress conditions such as dehydration and salt stress. β-D-Glucopyranosyl abscisate contributes to the maintenance of ABA homeostasis ^[1].

HY-N1487

Oleanonic acid 1 Publications Verification 3-Oxooleanolic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	HIV Autophagy Ferroptosis Amyloid-β
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats ^[1] .

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs ^[1] .

HY-N0492

α-Lipoic Acid 5+ Cited Publications Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent *HIV-1* LTR activation ^[1] . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium 5+ Cited Publications Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent *HIV-1* LTR activation ^[1] . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0645

Dicoumarol 5+ Cited Publications Dicumarol	Structural Classification Melilotus officinalis (L.) Pall. Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	PDHK
Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and *PDK1* with IC₅₀s of 0.37 and 19.42 μM, respectively.

HY-N10191

Hydroaurantiogliocladin	Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Disease Research Fields	Cytochrome P450
Hydroaurantiogliocladin is a quinol. Hydroaurantiogliocladin can be used as substrate for the quinol-cytochrome c oxidoreductase activity (beef heart enzyme) ^[1].

HY-W783829

(2E)-Hexenoyl-CoA Hex-2-trans-enoyl-CoA	Microorganisms Source classification	Endogenous Metabolite
(2E)-Hexenoyl-CoA (Hex-2-trans-enoyl-CoA) is an intermediate in fatty acid metabolism. (2E)-Hexenoyl-CoA is the substrate of the enzymes enoyl-coenzyme A reductase, acyl-CoA oxidase, acyl-CoA dehydrogenase, long-chain-acyl-CoA dehydrogenase and Oxidoreductases .

HY-135024

Phenylacetyl CoA Phenylacetyl Coenzyme A	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phenylacetyl CoA is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica ^[1].

HY-U00141

ABTL-0812 α-Hydroxylinoleic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Bombacaceae Source classification Metabolic Disease Plants Pachira aquatica Aublet Disease Research Fields	Autophagy
ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity ^[1].

HY-N3642

Cristacarpin Erythrabyssin I; Erythrabissin I	Leguminosae Erythrina suberosa Roxb. Source classification Plants	Others
Cristacarpin can be extracted from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sublethal reactive oxygen species (ROS) production and ultimately cell death through senescence ^[1].

HY-N4202

Dihydrorotenone	Erycibe ferruginea C. Y. Wu Flavonoids Neurological Disease Classification of Application Fields Isoflavanones Source classification Plants Disease Research Fields Convolvulaceae Biological Pesticide Research Agricultural Research	Mitochondrial Metabolism Apoptosis
Dihydrorotenone, a natural pesticide, is a potent mitochondrial inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway ^[1].

HY-N5058

Dehydroeffusol	Structural Classification Natural Products Juncus effusus Linn. Juncaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity ^[1] .

HY-W011241

Cinchonine hydrochloride (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride	Alkaloids other families Classification of Application Fields Source classification Quinoline Alkaloids Plants Disease Research Fields Cancer	Apoptosis Parasite
Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells ^[1].

HY-N6036

Ganoderic acid F 1 Publications Verification	Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Cancer	Others
Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress ^[1] .

HY-13433

Thapsigargin 80+ Cited Publications	Infection Classification of Application Fields Terpenoids Source classification Diterpenoids Umbelliferae Plants Disease Research Fields Thapsia garganica L. Cancer	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types ^[1] .

HY-16592

Brefeldin A 85+ Cited Publications BFA; Cyanein; Decumbin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Disease Research Anticancer Disease Research Fields	Autophagy CRISPR/Cas9 Mitophagy HSV Antibiotic Bacterial
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus ^[1] . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A inhibits *HSV-1* and has anti-cancer activity .

HY-N8439

Questiomycin A Phx-3	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	HSP Bacterial Antibiotic
Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases ^[1] .

HY-Y0152

Cinchonine 4 Publications Verification (8R,9S)-Cinchonine; LA40221	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Cancer	Apoptosis Parasite Autophagy Caspase Calcium Channel
Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells ^[1].

HY-N3831

Epimedokoreanin B	Structural Classification Flavonoids Flavones Epimedium koreanum Nakai Source classification Plants Berberidaceae	Bacterial Apoptosis
Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and *Porphyromonas gingivalis* growth and biofilm formation ^[1] .

HY-100355

C18-Ceramide	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
C18-Ceramide is a bioactive molecule with multiple functions in cells, can cross the blood-brain barrier, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology ^[1] .

HY-N6036R

Ganoderic acid F (Standard)	Triterpenes Structural Classification Microorganisms Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants	Others
Ganoderic acid F (Standard) is the analytical standard of Ganoderic acid F. This product is intended for research and analytical applications. Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress ^[1] .

HY-16592R

Brefeldin A (Standard) BFA (Standard); Cyanein (Standard); Decumbin (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antiviral Disease Research Anticancer	Autophagy CRISPR/Cas9 Mitophagy HSV Antibiotic Bacterial
Brefeldin A (Standard) (BFA (Standard)) is the analytical standard of Rutin. This product is intended for research and analytical applications. Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A inhibits HSV-1 and has anti-cancer activity.

HY-N6771

Cyclopiazonic acid 4 Publications Verification	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Disease Research Fields Indole Alkaloids	Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

HY-Y0152R

Cinchonine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants	Apoptosis Parasite Autophagy Caspase Calcium Channel
Cinchonine (Standard) is the analytical standard of Cinchonine. This product is intended for research and analytical applications. Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells ^[1].

HY-N0270

Ononin 5+ Cited Publications Ononoside; Formononetin 7-O-β-D-glucopyranoside	Structural Classification Flavonoids other families Classification of Application Fields Leguminosae Source classification Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones	ERK JNK p38 MAPK PI3K Akt mTOR Apoptosis
Ononin is an orally active isoflavone. Ononin inhibits the ERK/JNK/p38 and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy ^[1] .

HY-W009783

1-Deoxymannojirimycin hydrochloride 1 Publications Verification	Infection Alkaloids Piperidine Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields	HIV Influenza Virus
1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits *HIV‐1* strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity ^[1] .

HY-N0270R

Ononin (Standard)	Structural Classification Flavonoids other families Leguminosae Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Glycyrrhiza uralensis Fisch. Isoflavones	Others
Ononin (Standard) is the analytical standard of Ononin. Ononin is an orally active isoflavone. Ononin inhibits the ERK/JNK/p38 and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy ^[1] .

HY-B0075

Melatonin 95+ Cited Publications N-Acetyl-5-methoxytryptamine	Structural Classification Natural Products Other disease Neurological Disease Classification of Application Fields Anti-aging Source classification Endogenous metabolite Microorganisms Disease markers Inflammation/Immunology Disease Research Fields Cancer	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis
Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties ^[1] . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-A0098

Tunicamycin Maximum Cited Publications 110 Publications Verification	Structural Classification Antifungal Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Antiviral Anticancer Inflammation/Immunology Disease Research Fields	Bacterial Fungal Influenza Virus Antibiotic
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity ^[1] .Tunicamycin increases exosome release in cervical cancer cells .

HY-N6778

Paxilline 5+ Cited Publications	Alkaloids Structural Classification Microorganisms other families Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Indole Alkaloids	Potassium Channel Calcium Channel Reactive Oxygen Species
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity ^[1] .

HY-103312

Xestospongin C 4 Publications Verification (-)-Xestospongin C	Alkaloids Piperidine Alkaloids Structural Classification Animals Source classification	Calcium Channel Apoptosis
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells ^[1] .

HY-125954A

Uridine diphosphate glucuronic acid ammonium UDP-α-D-glucuronic acid ammonium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum ^[1].

HY-125954

Uridine diphosphate glucuronic acid UDP-α-D-glucuronic acid	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum ^[1] .

HY-113027R

p-Hydroxymandelic acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
Melatonin (Standard) is the analytical standard of Melatonin. This product is intended for research and analytical applications. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties ^[1] . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-B0075R

Melatonin (standard) N-Acetyl-5-methoxytryptamine (standard); Melatonin	Structural Classification Natural Products Microorganisms Other disease Source classification Disease markers Endogenous metabolite	Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis
Melatonin (Standard) is the analytical standard of Melatonin. This product is intended for research and analytical applications. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties ^[1] . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-N2877

Annonacin	Structural Classification Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Source classification Plants Annonaceae Disease Research Fields	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W ^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and *sarcoplasmic reticulum* (SERCA) ATPase pumps**. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways ^[1] .

HY-N0492AR

α-Lipoic Acid (sodium) (Standard)	Natural Products Source classification Endogenous metabolite	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis

HY-N0492R

α-Lipoic Acid (Standard) 5+ Cited Publications Thioctic acid (Standard); (±)-α-Lipoic acid (Standard); DL-α-Lipoic acid (Standard)	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent *HIV-1* LTR activation ^[1] . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-135024A

Phenylacetyl CoA lithium Phenylacetyl Coenzyme A lithium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phenylacetyl CoA lithium (Phenylacetyl Coenzyme A lithium) is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica ^[1].

Cat. No.	Product Name	Chemical Structure

HY-15654S

Phenylbutyrate-d11 sodium
Phenylbutyrate-d₁₁ (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[1].

HY-A0281S

4-Phenylbutyric acid-d11
4-Phenylbutyric acid-d₁₁ is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-19696S

Tauroursodeoxycholate-d5
Tauroursodeoxycholate-d₅ is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696AS

Tauroursodeoxycholate-d4 sodium
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N0492S

α-Lipoic Acid-d5
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

HY-137813S

PERK-IN-4-d3
PERK-IN-4-d₃ is the deuterium labeled PERK-IN-4. PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states[1].

HY-19696S1

Tauroursodeoxycholate-d4
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-A0281S3

4-Phenylbutyric acid-d2
4-Phenylbutyric acid-d₂ is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-19696S2

Tauroursodeoxycholate-d4-1
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-A0281S2

4-Phenylbutyric acid-d5
4-Phenylbutyric acid-d₅ is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[2][3][4].

HY-B0075S1

Melatonin-d3

Melatonin-d₃ is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties ^[1] . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-W012722BS

4-Methyl-2-oxopentanoic acid-d7 sodium

4-Methyl-2-oxopentanoic acid-d₇ (α-Ketoisocaproic acid-d₇) sodium is the deuterium labeled 4-Methyl-2-oxopentanoic acid (HY-W012722).4-Methyl-2-oxopentanoic acid is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways ^[1] .

HY-B0075S2

Melatonin-d7

Melatonin-d₇ is the deuterium labeled Melatonin (HY-B0075). Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties ^[1] . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

HY-14874S

Topiroxostat-d4
Topiroxostat-d₄ is deuterium labeled Topiroxostat. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment[1][2].

HY-W011690S

L-Homocystine-d8
L-Homocystine-d₈ is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

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