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By Targets:	GDNF Receptor (1) 5-HT Receptor (4) Akt (2) Aldose Reductase (1) Amylases (1) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (3) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (10) Apoptosis (55) Arp2/3 Complex (1) Atg7 (1) Atg8/LC3 (1) Autophagy (14) Bacterial (18) Bcl-2 Family (5) Bcr-Abl (2) Biochemical Assay Reagents (2) BMI1 (2) c-Kit (1) c-Met/HGFR (2) c-Myc (1) Calcium Channel (2) Carbonic Anhydrase (2) Casein Kinase (1) Caspase (9) CDK (9) Cholinesterase (ChE) (3) COX (5) CXCR (1) Cyclophilin (1) Cytochrome P450 (2) Deubiquitinase (1) DNA Alkylator/Crosslinker (1) DNA-PK (1) DNA/RNA Synthesis (6) Drug Metabolite (3) Dynamin (2) EGFR (6) Endogenous Metabolite (18) Endonuclease (1) Endothelin Receptor (1) Epigenetic Reader Domain (8) ERK (4) Estrogen Receptor/ERR (1) FAP (1) Fatty Acid Synthase (FASN) (3) Ferroptosis (4) FGFR (3) Fluorescent Dye (3) Free Fatty Acid Receptor (2) Fungal (4) G-quadruplex (2) GLP Receptor (1) Glucosidase (1) Glutaminase (1) Glutathione Peroxidase (1) GSK-3 (2) HBV (7) HDAC (6) Hedgehog (2) Histone Acetyltransferase (4) Histone Demethylase (6) Histone Methyltransferase (3) HIV (1) HIV Integrase (1) HSP (2) HSV (2) IAP (1) Influenza Virus (1) Integrin (1) Interleukin Related (1) IRAK (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (5) JAK (1) JNK (2) Keap1-Nrf2 (1) LPL Receptor (1) MCHR1 (GPR24) (2) MDM-2/p53 (5) MEK (1) Methionine Adenosyltransferase (MAT) (1) mGluR (1) Microtubule/Tubulin (17) MMP (2) Molecular Glues (3) Monoamine Oxidase (1) Motilin Receptor (1) NAMPT (2) Necroptosis (2) NEKs (1) NF-κB (6) NO Synthase (3) Nucleoside Antimetabolite/Analog (2) Orthopoxvirus (2) P-glycoprotein (3) Parasite (7) PARP (6) PDGFR (1) PGE synthase (1) Phosphatase (2) Phosphodiesterase (PDE) (2) PI3K (4) Pim (1) PKA (1) PKC (1) PPAR (1) PROTACs (9) Proteasome (1) Pyroptosis (1) Raf (3) Ras (1) Reactive Oxygen Species (11) RET (1) Reverse Transcriptase (2) RSV (1) SARS-CoV (2) Ser/Thr Protease (2) Sirtuin (4) Smo (2) Sodium Channel (1) STAT (7) Syk (1) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (2) Toll-like Receptor (TLR) (2) Topoisomerase (3) Trk Receptor (1) VEGFR (5) Virus Protease (3) Wnt (2) YAP (1) β-catenin (4)
By Research Areas:	Cancer (263) Cardiovascular Disease (12) Endocrinology (5) Infection (43) Inflammation/Immunology (29) Metabolic Disease (6) Neurological Disease (18)
Click Chemistry:	Azide (2)
Oligonucleotides:	Aptamers (4) Phospholipids (1) mRNA (1)

349

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Hsp110-STAT3 interaction-IN-1	Others	Cardiovascular Disease
Row174336 (compound 29) is a potent inhibitor of Hsp110-STAT3 interaction that shows antiproliferative activity against HPAEC cell line, with the IC₅₀ of 22.67 μM .

Neohelmanthicin A	Others	Cancer
Neohelmanthicin A (compound 3A) is a phenylpropanoid compound with antitumor activity. The IC₅₀s of Neohelmanthicin A for inhibiting leukemia cell line EL4, breast cancer cell line S180 and breast cancer cell line MCF7 are 0.13 μM, 7 μM and 23 μM respectively .

Aleniglipron	GLP Receptor	Metabolic Disease
Aleniglipron (compound 121a) is a GLP-1 agonist with an EC₅₀ value of less than 0.1 nM in the HDB cell line in a cAMP stimulation assay .

Moflomycin F 860191	Others	Cancer
Moflomycin (F 860191) is a compound with strong anti-leukemic activity and low mutagenicity. Moflomycin has an antiproliferative effect on the leukemic cell line HL60 in vitro (IC₅₀=2.9 nM) .

Coclauril	HBV	Infection
Coclauril is an inhibitor of HBV. Coclauril inhibits HBV replication in the human hepatoblastoma cell line with an EC₅₀ of 7.6 μg/mL .

Dihydrodehydrodiconiferyl alcohol	TNF Receptor	Cancer
Dihydrodehydrodiconiferyl alcohol (compound 2) is a kind of neolignan. Dihydrodehydrodiconiferyl alcohol can be isolated from Anogeissus acuminata. Dihydrodehydrodiconiferyl alcohol has specific cytotoxic activity on melanoma cancer cell line .

(-)-Rasfonin	Ras Apoptosis Autophagy	Cancer
(-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line) .

8-Lavandulylkaempferol	Others	Cancer
8-Lavandulylkaempferol is a flavonoid that can be isolated from Sophora flaWescens. 8-Lavandulylkaempferol exhibits cytotoxic activity against the KB epidermoid carcinoma cell line with an IC₅₀ of 15.1 μg/mL .

Ronipamil	Calcium Channel	Cardiovascular Disease Cancer
Ronipamil is a calcium ion antagonist. Ronipamil increases the specific binding and internalization of human ¹²⁵I-LDL in human skin fibroblasts (HSF) and the human hepatoma cell line Hep G2 .

NU-7163	DNA-PK	Cancer
NU-7163 is an ATP-competitive DNA-PK inhibitor (IC₅₀=0.19 μM; K_i=24 nM). NU-7163 enhances the cytotoxicity of ionizing radiation against the HeLa human tumor cell line in vitro .

MDM2/XIAP-IN-2	MDM-2/p53	Cancer
MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC₅₀ value of 0.3 μM .

Debrisoquin Debrisoquine; Isocaramidine; Ro 5-3307/1	SARS-CoV Ser/Thr Protease	Infection
Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC₅₀ of 22μM. Debrisoquin can be used for antiviral research .

Anticancer agent 90	Virus Protease	Cancer
Anticancer agent 90 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity. Anticancer agent 90 has high inhibition against the two cell line from ovarian cancer (OVCAR-4), renal cancer (A498) .

Anticancer agent 91	Antibiotic	Cancer
Anticancer agent 91 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. Anticancer agent 91 has high inhibition against the two cell line from CNS cancer (SF-539 and SNB-75) .

Anticancer agent 89	Others	Cancer
Anticancer agent 89 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity, has high inhibition against the three cell line from ovarian cancer (OVCAR-4), renal cancer (A498), and melanoma (SK-MEL-5) .

Debrisoquin hemisulfate Debrisoquine hemisulfate; Isocaramidine hemisulfate; Ro 5-3307/1 hemisulfate	Endogenous Metabolite	Infection Cardiovascular Disease
Debrisoquin (Isocaramidine) hemisulfate is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC₅₀ of 22μM. Debrisoquin hemisulfate can be used for antiviral research .

Veltuzumab IMMU-106; hA20	Integrin	Cancer
Veltuzumab (IMMU-106) is a humanized anti-CD20 monoclonal antibody. Veltuzumab has low EC₅₀ value of 0.08-0.09 μg/mL in the Daudi cell line. Veltuzumab can be used for the research of cancer including non-Hodgkin lymphoma (NHL) .

Saquayamycin B	Antibiotic	Infection Cancer
Saquayamycin B (compound 3) is a new angucycline antibiotic. Saquayamycin B has antitumor activities against a human lung (H-460) and a human breast cancer cell line (MCF-7) with GI₅₀ values of 12.2 and 15.2 µM respectively .

Debrisoquin hydroiodide Debrisoquine hydroiodide; Isocaramidine hydroiodide; Ro 5-3307/1 hydroiodide	SARS-CoV Ser/Thr Protease	Infection
Debrisoquin (hydroiodide) is the hydrochloride form of Debrisoquin (HY-B1624). Debrisoquin is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner. Debrisoquin can be used for antiviral research .

HCVcc-IN-2	Virus Protease	Infection Cancer
HCVcc-IN-2 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. HCVcc-IN-2 has high inhibition against the three cell line from CNS cancer (SF-539 and SNB-75), colon cancer (HCT-116), and renal cancer (A498) .

MMs02943764	MDM-2/p53	Cancer
MMs02943764 is a 1,2,4-triazole derivative with anticancer activity. MMs02943764 has significant antiproliferative effects on multiple cancer cell lines. PAC, a structural analog of MMs02943764, has significant cytotoxicity against the leukemia cell line K562 (IC₅₀=35.264 μM), reduces the degradation of p53 by inhibiting Mdm2 and Pirh2, and induces K562 cell cycle arrest .

Allylthiourea Thiosinamine; N-Allylthiourea	Reactive Oxygen Species	Cancer
Allylthiourea can selectively inhibit the oxidation of ammonia. Allylthiourea is commonly used to inhibit nitrification by targeting ammonia monooxygenase and chelating copper in the active site to suppress its activity. Allylthiourea also exhibits anticancer activity, showing cytotoxicity against the MCF-7 cell line with an IC₅₀ of 5.22 mM. Allylthiourea can be utilized in research related to micropollutant biodegradability and cancer studies .

OM-1700	PARP	Cancer
OM-1700 is a potent tankyrase inhibitor with IC₅₀s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI₅₀=650 nM) .

AD16	Endonuclease	Inflammation/Immunology
AD16 (Acetamide) is a LINE-1 retrotransposon endonuclease inhibitor with the IC₅₀ of 4.7 μM. AD16 (Acetamide) reduce LINE-1 retrotransposition, L1-induced DNA damage, and inflammation reinforced by L1 in senescent cells .

Tretazicar CB 1954	DNA Alkylator/Crosslinker	Cancer
Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .

Peplomycin Bleomycin PEP; Pepleomycin	Antibiotic	Cancer
Peplomycin (Bleomycin PEP; Pepleomycin) is an antibiotic analogue of Bleomycin (HY-108345), with high antitumor effect and less pulmonary toxicity. Peplomycin induce apoptosis in oral squamous carcinoma cell line SSCKN cells and pulmonary fibrosis in rats .

RAF-IN-1	Raf	Cancer
RAF-IN-1 is a potent b/cRAF inhibitor with an IC₅₀s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAF ^wt, and bRAF ^V600E. RAF-IN-1 shows cell growth inhibition with GI₅₀s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAF ^V600E mutation, respectively .

11-epi-Chaetomugilin I	Endogenous Metabolite	Cancer
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

Ganoderic acid R	Apoptosis	Cancer
Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing apoptosis on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1) .

2,3-Diphospho-D-glyceric acid pentasodium salt 2,3-DPG pentasodium salt	Others	Cardiovascular Disease
2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects .

PP5-IN-2	Phosphatase	Cancer
PP5-IN-2 is an orally active and selective protein phosphatase 5 (PP5) inhibitor with an IC₅₀ value of 0.9 μM. PP5-IN-2 activates p53 and downregulates cyclin D1 and MGMT, which shows potency in cell cycle arrest and reverses Temozolomide (TMZ) (HY-17364) resistance in the U87 MG cell line. PP5-IN-2 effectively inhibits tumor growth in the xenograft mouse model .

Ethionamide 1 Publications Verification 2-Ethylthioisonicotinamide	Bacterial Antibiotic	Infection
Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic.

Vitexolide E 12-epi-Vitexolide D; Curcucomosin C	Others	Cancer
Vitexolide E is a diterpenoid compound isolated from the leaves of the Malaysian species Vitex vestita. Vitexolide E shows cytotoxic activities against the HCT-116 cancer cell line and human fetal lung fibroblast MRC5 cell line .

Dexylosyltubeimoside Ⅲ	Others	Cancer
Dexylosyltubeimoside Ⅲ (compound 3) is a cyclic disoside that can be isolated from Actinostemma lobatum MAXIM. Dexylosyltubeimoside Ⅲ has in vitro anticancer activity and inhibits the growth of human esophageal cancer cell line ECA109 (IC50=22.37 μM), lung cancer cell line A549 (IC50=27.27 μM) and gastric cancer cell line MGC-803 (IC50=36.85 μM) .

ML243	Others	Cancer
ML243 is a selective small-molecule inhibitor of breast cancer stem cells. ML243 has 32-fold greater selective inhibition in the breast CSC-like cell line HMLE_shECad than the control cell line HMLE_shGFP .

Pinobanksin 3,5,7-Trihydroxyflavanone	Apoptosis	Others
Pinobanksin has apoptotic induction in a B-cell lymphoma cell line .

CDK9-IN-2 5 Publications Verification	CDK	Cancer
CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor, extracted from patent WO/2012131594A1, compound CDKI(8), has an IC₅₀ of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.

Lumefantrine 1 Publications Verification Benflumetol	Parasite	Infection
Lumefantrine is an active antimalarial molecule used in combination with Artemether as a first- and second-line antimalarial drug with oral activity .

Epicorynoxidine	Others	Inflammation/Immunology
Epicorynoxidine, a natural alkaloid, shows cytotoxic effects P-388 cell line with an ED₅₀ of 25.53 μg/mL .

(±)-Pinocembrin (±)-5,7-Dihydroxyflavanone; NSC 43318	Free Fatty Acid Receptor	Others
(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line .

Sanggenol P	HBV	Infection
Sanggenol P, a flavonoid, shows anti-HBV activity on HepG2.2.15 cell line in vitro .

(+)-Menthyl acetate	Biochemical Assay Reagents	Others
(+)-Menthyl acetate is a compound isolated from natural Cunila angustifolia Benth essential oil. The selectivity of (+)-Menthyl acetate is higher than that of MCF-7 cell line, IC₅₀=34.0 μg?mL ^-1, and lower than that of SK-Mel-28 cell line, IC₅₀=279.9 μg?mL ^-1, on A549 cell without fatal .

Pheophytin a	Reactive Oxygen Species	Endocrinology
Pheophytin a is a chlorophyll that can be isolated from S. vermiculata extracts. Pheophytin a has antioxidant activity with IC₅₀ values of? 200.5 and 137.7 μg/mL for SOD, and NO respectively. Pheophytin a has reducing power with an IC₅₀ value of 4.2 μg/mL . Pheophytin a has a cytotoxic effect on the MCF-7 cell line(IC₅₀= 35.9 μg/mL)^[1].

Betulin 5+ Cited Publications Trochol	Fatty Acid Synthase (FASN) Apoptosis Endogenous Metabolite	Cancer
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC₅₀ of 14.5 μM in K562 cell line.

LSD1-UM-109	Histone Demethylase	Cancer
LSD1-UM-109 is a ighly potent and reversible LSD1 inhibitor with an IC₅₀ of 3.1 nM. LSD1-UM-109 inhibits cell growth with IC₅₀ values of 0.6 nM in the MV4;11 acute leukemia cell line and 1.1 nM in the H1417 small-cell lung cancer cell line .

(+)-Epieudesmin	Bacterial	Infection Cancer
(+)-Epieudesmin is an antineoplastic agent. (+)-Epieudesmin has marginal cancer cell line inhibitory activities. (+)-Epieudesmin inhibits the growth of Gram-negative pathogen .

Cat. No.	Product Name

HY-L174

Macrophage Related Compound Library

173 compounds

Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance.

MCE designs a unique collection of 173 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Type

HY-D0047

5-CFDA 3 Publications Verification 5-Carboxyfluorescein diacetate	Fluorescent Dyes/Probes
5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D0721

6-CFDA 6-Carboxyfluorescein diacetate	Fluorescent Dyes/Probes
6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D0722

5(6)-CFDA 5 Publications Verification 5-(6)-Carboxyfluorescein diacetate; CFDA	Fluorescent Dyes/Probes
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D2380

H2S probe 1	Fluorescent Dyes/Probes
H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC₅₀=77.9 nM) and has a high affinity for human telomeric G-quadruplex (G4) (K_d=1.72 μM). H2S probe 1 can be used in cancer research .

Cat. No.	Product Name	Type

HY-B0812

5-Sulfosalicylic acid dihydrate SSA dihydrate	Chelators
5-Sulfosalicylic acid dihydrate is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid dihydrate is effective against the breast cancer cell line, MCF-7, with less toxicity . 5-Sulfosalicylic acid dihydrate has antioxidant activities .

Cat. No.	Product Name	Target	Research Area

HY-P1037

Motilin (26-47), human, porcine	Motilin Receptor	Others
Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with K_i and EC₅₀ of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

HY-P3333

KSPWFTTL	Peptides	Inflammation/Immunology Cancer
KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P3333A

KSPWFTTL TFA	Peptides	Inflammation/Immunology Cancer
KSPWFTTL TFA is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL TFA can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-125153

Bursin	Peptides	Others
Bursin is a peptide that can be isolated from the bursa of Fabricius of chicken. Bursin induces the phenotypic differentiation of mammalian and avian B precursor cells. Bursin also increases cyclic guanosine monophosphate in cells of the human B-cell line Daudi .

HY-P2291

Beta-defensin 103 isoform X1, pig	Bacterial	Inflammation/Immunology
Beta-defensin 103 isoform X1, pig is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens .

HY-P2291A

Beta-defensin 103 isoform X1, pig TFA	Bacterial	Inflammation/Immunology
Beta-defensin 103 isoform X1, pig TFA is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens .

HY-P2466

Bax BH3 peptide (55-74), wild type	Apoptosis	Cancer
Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models .

HY-168095

CXCR4 antagonist 10	CXCR	Cancer
CXCR4 antagonist 10 (compound 21) is a potent antagonist of CXCR4, with the IC₅₀ of 7.8 nM. CXCR4 antagonist 10 plays an important role in cancer research .

HY-P4135

FITC-LC-Antennapedia Peptide	Peptides	Others
FITC-LC-Antennapedia Peptide is a FITC labeled Antennapedia Peptide (HY-P0307). Antennapedia Peptide is a cellular-membrane permeable peptides (CPP). FITC-LC-Antennapedia Peptide has good penetration in 3T3 cell line, which was rapidly accumulated into nuclei .

HY-P3083

N-Myristoyl-Lys-Arg-Thr-Leu-Arg	PKC	Inflammation/Immunology
N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a protein kinase C (PKC) inhibitor with an IC₅₀ value of 75 μM. N-Myristoyl-Lys-Arg-Thr-Leu-Arg inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat .

HY-P1205

MCH(human, mouse, rat) Melanin-concentrating hormone(human, mouse, rat)	MCHR1 (GPR24)	Neurological Disease
MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC₅₀ values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC₅₀ values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively .

HY-P1205A

MCH(human, mouse, rat) TFA Melanin-concentrating hormone(human, mouse, rat) TFA	MCHR1 (GPR24)	Neurological Disease
MCH (human, mouse, rat) TFA is a potent peptide agonist of MCH-R and exhibits binding IC₅₀ values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC₅₀ values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P99224

Veltuzumab IMMU-106; hA20	Integrin	Cancer
Veltuzumab (IMMU-106) is a humanized anti-CD20 monoclonal antibody. Veltuzumab has low EC₅₀ value of 0.08-0.09 μg/mL in the Daudi cell line. Veltuzumab can be used for the research of cancer including non-Hodgkin lymphoma (NHL) .

Species:	Human (4) Rat (1) Canine (1)
Tag:	His (4) SUMO (1) Tag Free (1) Fc (1)
Source:	HEK293 (2) Sf9 insect cells (1) P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73074

	GDNF Protein, Human (HEK293) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Human	HEK293
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Human (HEK293) is produced in HEK293 cells, and consists of 103 amino acids (R83-I185).

HY-P73075

	GDNF Protein, Rat (sf9, His) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Rat	Sf9 insect cells
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Rat (sf9, His) is produced in Sf9 insect cells with a N-Terminal His-tag. It consists of 134 amino acids (S78-I211).

HY-P75169

	GDNF Protein, Canine (HEK293, Fc) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Canine	HEK293
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Canine (HEK293, Fc) is produced in HEK293 cells with a N-Terminal Fc-tag. It consists of 103 amino acids (R109-I211).

HY-P700084AF

	Animal-Free GDNF Protein, Human (His) Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3	Human	E. coli
	Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. Animal-Free GDNF Protein, Human (His), a recombinant animal-free protein, is produced in E.coil with a C-Terminal His-tag. It consists of 134 amino acids (S78-I211).

HY-P72116

	CAPZA2 Protein, Human (His-SUMO) CAPPA2 ; Capping protein actin filament; muscle Z line; alpha 2 ; CapZ alpha 2; CapZ alpha-2; CAPZ; CAPZA2; CAZA2_HUMAN; F actin capping protein alpha 2 subunit; F actin capping protein subunit alpha 2; F-actin-capping protein subunit alpha-2	Human	E. coli
	The CAPZA2 protein is a member of the F-actin capping protein family and binds to the barbed ends of actin filaments, preventing subunit exchange without severing the filaments. CAPZA2 Protein, Human (His-SUMO) is the recombinant human-derived CAPZA2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CAPZA2 Protein, Human (His-SUMO) is 285 a.a., with molecular weight of ~48.8 kDa.

HY-P700509

	TFF1 Protein, Human (P. pastoris, N-His) TFF1; BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2; trefoil factor 1; gastrointestinal trefoil protein pS2; breast cancer estrogen-inducible sequence; Breast cancer estrogen-inducible protein; breast cancer, estrogen-inducible sequence expressed in gastrointestinal trefoil protein pS2; pS2 protein; trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancer cell line M	Human	P. pastoris
	TFF1 protein functions as a mucous gel stabilizer, vital for fortifying the gastrointestinal mucosa against noxious agents. It contributes to the mucous layer's integrity, providing a crucial physical barrier for the gastrointestinal tract, safeguarding it from potential harm. TFF1's stabilizing role emphasizes its significance in preserving the mucosal barrier, essential for overall gastrointestinal health and protection. TFF1 Protein, Human (P. pastoris, N-His) is the recombinant human-derived TFF1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of TFF1 Protein, Human (P. pastoris, N-His) is 60 a.a., with molecular weight of 8.7 kDa.

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HY-P81154

	CXCL10/IP10 Antibody 10 kDa interferon gamma induced protein; C7; Chemokine (C X C motif) ligand 10; Chemokine CXC motif ligand 10; Crg 2; CRG2; CXCL 10; CXCL10; Gamma IP10; gIP 10; GIP10; IFI 10; IFI10; INP 10; INP10; Interferon activated gene 10; Interferon gamma induced cell line; Interferon inducible cytokine IP 10; MOB1; SCYB 10; SCYB10; Small inducible cytokine B10; Small inducible cytokine B10 precursor; Small inducible cytokine subfamily B (Cys X Cys) member 10; Gamma-IP-10.	ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat,
	CXCL10/IP10 Antibody is an unconjugated, approximately 10 kDa, rabbit-derived, anti-CXCL10/IP10 polyclonal antibody. CXCL10/IP10 Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, background without labeling.

HY-P81518

	LINE-1 ORF1p Antibody (YA1263) LRE1; L1RE1; line-1 retrotransposable element ORF1 protein; L1ORF1p; line retrotransposable element 1; line1 retrotransposable element 1	IHC-P	Human
	LINE-1 ORF1p Antibody (YA1263) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1263), targeting LINE-1 ORF1p. LINE-1 ORF1p Antibody (YA1263) can be used for IHC-P experiment in human background.

HY-P83294

	LINE 1 ORF1p Antibody (YA3039) L1ORF1p; L1RE1; LRE1	WB, IP	Human
	LINE 1 ORF1p Antibody (YA3039) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3039), targeting LINE 1 ORF1p, with a predicted molecular weight of 40 kDa (observed band size: 40 kDa). LINE 1 ORF1p Antibody (YA3039) can be used for WB, IP experiment in human background.

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Cat. No.	Product Name		Classification

HY-159495

Keap1-Nrf2-IN-21		Azide
Keap1-Nrf2-IN-21 (compound 4d) is a glucose metabolism inhibitor with antitumor activity. Keap1-Nrf2-IN-21 inhibits glycolytic activity of cancer cells by targeting the glycolytic pathway, especially by affecting the Keap1-Nrf2 signaling pathway, thereby inhibiting tumor growth. Keap1-Nrf2-IN-21 exhibits cytotoxicity against the HEC1A cell line (IC₅₀=2.60 μM) .

HY-159564

iNOS/COX-2-IN-3		Azide
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

Cat. No.	Product Name		Classification

HY-160055

GMT 4 aptamer sodium		Aptamers
GMT 4 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM .

HY-160057

GMT 8 aptamer sodium		Aptamers
GMT 8 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM .

HY-160066

SYL3C aptamer sodium		Aptamers
SYL3C aptamer sodium is a DNA aptamer that targets the epithelial cell adhesion molecule (EpCAM) on the surface of cancer cells. SYL3C aptamer sodium targets multiple human cancer cell lines including MDA-MB-231, Kato III, HT-29, T47D and SW480. The Kd of SYL3C aptamer sodium against breast cancer cell line MDA-MB-231 and gastric cancer cell line Kato III is 38 nM and 67 nM, respectively. SYL3C aptamer sodium provides stability, high binding affinity, and selectivity for targeted cancer therapy, cancer cell imaging, and circulating tumor cell detection .

HY-160059

JHIT2e aptamer sodium		Aptamers
JHIT2e aptamer sodium is a molecular probe based on the aptamer JHIT2 of human liver cancer cell line HepG2 cells. JHIT2e aptamer sodiu retains the ability to specifically bind HepG2 and can deliver fluorescent materials or radionuclides to tumors .

HY-157687

18:1 (Δ9-Trans) PC 1,2-Dielaidoyl-sn-glycero-3-phosphocholine		Phospholipids
18:1 (Δ9-Trans) PC (1,2-Dielaidoyl-sn-glycero-3-phosphocholine) is a phosphoglyceride with two unsaturated acyl chains. The product line is designed to offer compounds with different physical properties, including short chain (C3-C8, water soluble and hygroscopic), saturated, polyunsaturated and mixed acid PCs.

HY-164058

LZCap AG(3'Acm) RFP mRNA		mRNA
Red fluorescent protein (RFP) is a protein isolated from the Pacific anemone (Discosoma sp.) that can emit red fluorescence under ultraviolet light. RFP can be excited by the 488 nm or 532 nm laser line and is optimally detected at 588 nm. LZCap AG(3'Acm) RFP mRNA is synthesized and purified in a one-step transcription process using T7 RNA polymerase and LZCap AG(3'Acm) cap analog. This mRNA is suitable for experiments related to mRNA delivery, translation efficiency, transfection efficiency, and in vivo imaging.

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