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By Research Areas:	Cancer (111) Cardiovascular Disease (11) Endocrinology (5) Infection (64) Inflammation/Immunology (49) Metabolic Disease (14) Neurological Disease (70)
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294

Inhibitors & Agonists

Screening Libraries

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9929

Bezlotoxumab	Bacterial	Infection Inflammation/Immunology
Bezlotoxumab is a human monoclonal antibody directed against C. difficile toxin B. Bezlotoxumab binds to C. difficile toxin B preventing intestinal epithelial damage and colitis .

HY-P9957

Raxibacumab ABthrax	Bacterial	Infection
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .

HY-P5914A

*Wasabi Receptor Toxin* TFA** WaTx TFA	TRP Channel	Neurological Disease
Wasabi Receptor Toxin TFA (WaTx TFA) is the TFA salt form of Wasabi Receptor Toxin (HY-P5914). Wasabi Receptor Toxin TFA is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin TFA is the activator for TRPA1 ion channel with EC₅₀ in nanomolar level, and prolongs the channel open time, but reduces Ca ²⁺ permeability. Wasabi Receptor Toxin TFA causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .

HY-P5807A

*Cn2 toxin* TFA** β-Mammal toxin Cn2 TFA	Sodium Channel	Neurological Disease
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6 .

HY-P5152

*Scorpion toxin* Tf2**	Sodium Channel	Neurological Disease
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .

HY-157328

7PCGY	Others	Cancer
7PCGY is an ricin toxin A chain (RTA) inhibitor with an IC₅₀ value of 6?μM. 7PCGY can be used for the research of cell death .

HY-P5917

Vm24-toxin Vaejovis mexicanus peptide 24	Potassium Channel	Others
Vm24-toxin is a toxin peptide that can be isolated from the Mexican scorpion Vaejovis mexicanus smithy. Vm24-toxin is an inhibitor of Kv1.3 potassium channel .

HY-P10612

*Tetanus toxin* peptide**	Bacterial	Metabolic Disease
Tetanus toxin peptide is a specific peptide isolated from the toxin produced by Clostridium tetani. Tetanus toxin peptide can be used as an immunogen to induce diabetes in mice. Tetanus toxin peptide can be used in the study of type 1 diabetes .

HY-P4984

*Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)*	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) is a T cell proliferation activator. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) promotes the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) can be used in research on inflammatory and immunity, as well as cancer .

HY-P5175

*Muscarinic toxin* 7**	mAChR	Neurological Disease
Muscarinic toxin 7 is a peptide toxin with selective and noncompetitive antagonism at the muscarinic M1 receptor .

HY-P5914

Wasabi Receptor Toxin WaTx	TRP Channel	Neurological Disease
Wasabi Receptor Toxin is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin is the activator for TRPA1 ion channel with EC₅₀ in nanomolar level, and prolongs the channel open time, but reduces Ca ²⁺ permeability. Wasabi Receptor Toxin causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .

HY-P3071

ShK toxin Stichodactyla helianthus neurotoxin	Potassium Channel	Inflammation/Immunology
ShK toxin blocks voltage-dependent potassium channel (K_v1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .

HY-N14936

*AK-toxin* Ⅰ**	Fungal	Infection
AK-toxin I is a host-specific phytotoxic metabolite. AK-toxin I causes black spot disease of pear trees .

HY-P5857

MmTx2 toxin Micrurotoxin 2	GABA Receptor	Neurological Disease
MmTx2 toxin is a GABA_A receptor modulator that enhances GABA_A receptor sensitivity to agonists. MmTx2 toxin can be obtained from venom of coral snake. MmTx2 toxin can be used in the study of neurological diseases such as epilepsy, schizophrenia and chronic pain .

HY-P5807

Cn2 toxin β-Mammal toxin Cn2	Sodium Channel	Neurological Disease
Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage sensing domain of voltage gated sodium channels (Na_v) .

HY-126856

HC-Toxin	HDAC Apoptosis	Cancer
HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC₅₀ of 30 nM . HC-Toxin induces tumor cell apoptosis and has anticancer effects .

HY-P5782

δ-Theraphotoxin-Hm1a toxin	Sodium Channel	Neurological Disease
δ-Theraphotoxin-Hm1a toxin is a selective Na_v1.1 activator. δ-Theraphotoxin-Hm1a toxin elicits pain and touch sensitivity. δ-Theraphotoxin-Hm1a toxin can be used for the research of irritable bowel syndrome .

HY-111431AS

p-Cresol sulfate-d7 potassium p-Tolyl sulfate-d₇ (potassium)	Endogenous Metabolite	Metabolic Disease
p-Cresol sulfate-d₇ (potassium) is the deuterium labeled p-Cresyl sulfate potassium. p-Methylphenyl potassium sulfate is a prototype protein-bound uremic toxin[1][2].

HY-130959

Tubulysin IM-2	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-2 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-130960

Tubulysin IM-3	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-3 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-130958

Tubulysin IM-1	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-1 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis .

HY-124801

ABMA 1 Publications Verification	Flavivirus Dengue Virus Bacterial Parasite	Infection
ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity .

HY-P5854

Aa1 toxin	Potassium Channel	Neurological Disease
Aa1 toxin, a neurotoxic peptide that can be obtained from the venom of Androctonus australis Garzoni, is a specific potassium channel blocker. Aa1 toxin can be used in the study of neurological diseases .

HY-160791A

Claramine TFA	Others	Infection Cancer
Claramine TFA is a steroidal polyamine. Claramine TFA can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins .

HY-130067

Lolitrem B	Antibiotic	Infection
Lolitrem B is a toxin produced by the fungus Epichloe .

HY-160791

Claramine	Phosphatase	Infection Cancer
Claramine is a steroid polyamine with blood-brain barrier permeability. Claramine can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins .

HY-B1977

Dipropetryn GS 16068; Sancap; Cotofor	Herbicide	Others
Dipropetryn (GS 16068) is a compound that inhibits algal photosynthesis and toxin production. It can reduce the photosynthetic activity and pigment content of Karenia, reduce the levels of unsaturated fatty acids, reactive oxygen and hemolytic toxins, and regulate the expression of related proteins.

HY-P5943

Pterinotoxin-1	Sodium Channel	Neurological Disease
Pterinotoxin-1 is a sodium channel inhibitor peptide toxin .

HY-P5942

Pterinotoxin-2	Sodium Channel	Inflammation/Immunology
Pterinotoxin-2 is a sodium channel inhibitor peptide toxin .

HY-132180

Seco-DUBA hydrochloride	ADC Cytotoxin	Inflammation/Immunology Cancer
Seco-DUBA hydrochloride is a toxin for ADC drug SYD985 .

HY-122191

*AK-Toxin* II**	Others	Infection
AK-Toxin II is a phytotoxic metabolite that can be isolated from culture broth of alternaria alternata Japanese pear pathotype. AK-Toxin II induces characteristic veinal necrosis and rapid K ⁺ loss on susceptible pear leaves .

HY-P99551

Tosatoxumab KBSA301; AR-301	Antibiotic	Infection
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes *alpha-toxin* (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent .

HY-114748

AHU1	Bacterial	Infection
AHU1 is a compound that inhibits the expression of Shiga toxin type 2 in Escherichia coli O157:H7, demonstrating a dose-dependent reduction in toxin activity by interfering with the SOS response through its effects on RecA.

HY-112779

Pertussis Toxin 5+ Cited Publications	Endogenous Metabolite	Infection
Pertussis Toxin is a protein-based AB₅-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins .

HY-15581

MMAD Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10	Microtubule/Tubulin ADC Cytotoxin	Cancer
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).

HY-P10572

HG1 Toxin	Ser/Thr Protease Potassium Channel	Inflammation/Immunology Endocrinology
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (K_i=107 nM) and can be used in the study of autoimmune diseases .

HY-P3394

*Cholera toxin* B subunit, from vibrio cholerae** CTB, from vibrio cholerae	Biochemical Assay Reagents	Others
Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

HY-P2031

Phallacidin	Arp2/3 Complex	Others
Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin .

HY-126484

Eremofortin B	Fungal	Others
Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT) .

HY-W001117

3,5-Dimethoxyphenol Phloroglucinol Dimethyl Ether	Endogenous Metabolite	Metabolic Disease
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

HY-P0028

Phalloidin 10+ Cited Publications	Fluorescent Dye	Others
Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome .

HY-P99447

Atidortoxumab	Bacterial	Infection
Atidortoxumab is a human IgG1κ monoclonal antibody that targets Staph aureus alpha toxin .

HY-132162

7-MAD-MDCPT	ADC Cytotoxin	Cancer
7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs) .

HY-P1441

Mambalgin 1	Sodium Channel	Others
Mambalgin-1 is a toxin isolated from black mamba venom. Mambalgin-1 is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger toxins. Mambalgin-1 can bind to and stabilize ASICs (acid-sensing ion channels) in a physiologically relevant closed-channel conformation .

HY-121404

Muscarine (+)-Muscarine	mAChR	Neurological Disease
Muscarine ((+)-Muscarine) is an agonist of prototype mAChR. Muscarine is a toxin that can stimulate the parasympathetic nervous system .

HY-121404A

Muscarine chloride (+)-Muscarine chloride	mAChR	Neurological Disease
Muscarine ((+)-Muscarine) chloride is an agonist of prototype mAChR. Muscarine chloride is a toxin that can stimulate the parasympathetic nervous system .

HY-78932

Dap-NE	ADC Cytotoxin	Cancer
Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162) .

HY-121404B

Muscarine tosylate (+)-Muscarine tosylate	mAChR	Neurological Disease
Muscarine ((+)-Muscarine) tosylate is an agonist of prototype mAChR. Muscarine tosylate is a toxin that can stimulate the parasympathetic nervous system .

HY-130476

Satratoxin G	Caspase Apoptosis	Cancer
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

HY-P99898

Setoxaximab	Bacterial	Others
Setoxaximab is an IgG1-κ humanized chimeric antibody targeting shiga toxin type 1 .

Cat. No.	Product Name

HY-L101

Anti-Liver Cancer Compound Library

2,174 compounds

Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.

Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.

MCE offers a unique collection of 2,174 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

HY-L194

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

1,316 compounds

Heat-clearing and detoxification is a specific treatment method in the research of traditional Chinese medicine (TCM), which is clinically used to treat infectious diseases with remarkable effect. Over the past decades, the research of heat-clearing and detoxification treatment has been one of the most active fields of combining traditional Chinese and western medicines, and has made remarkable achievements. Nowadays, the application field of heat-clearing and detoxification traditional Chinese medicine is not only limited to antibacterial and antiviral, but also has made progress in the research fields of anti-inflammatory reaction, anti-endotoxin, anti-peroxidative damage, anti-inflammatory cytokines, enhancement of immune function, protection of cellular organelles, and maintenance of calcium homeostasis. In addition to this, clearing heat and removing toxins has also made significant research progress in non-infectious diseases, for example, in tumors, cardiovascular diseases, renal diseases, blood diseases, geriatrics, and diabetes, all of which have shown good curative effect.

MCE can supply 1,316 monomer component from more than a hundred sources of heat-clearing and detoxification TCM, which can be used in TCM studies, drug development and mechanism-based studies.

Cat. No.	Product Name	Type

HY-P3394

Cholera toxin B subunit, from vibrio cholerae

CTB, from vibrio cholerae

Native Proteins

Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

HY-119491

Ethyl tricosanoate	Biochemical Assay Reagents
Ethyl Tricosanoate is a long-chain saturated fatty acid ethyl ester, which exists in small amounts in C. conicum and C. conicum. Free acid reduces the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes. Both ethyl ester and free acid can be used as standards for the analysis of lipid mixtures.

Cat. No.	Product Name	Target	Research Area

HY-P9929

Bezlotoxumab	Bacterial	Infection Inflammation/Immunology
Bezlotoxumab is a human monoclonal antibody directed against C. difficile toxin B. Bezlotoxumab binds to C. difficile toxin B preventing intestinal epithelial damage and colitis .

HY-P99277

Actoxumab Anti-C. difficile Toxin A Recombinant Antibody	Inhibitory Antibodies	Infection
Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB .

HY-P9957

Raxibacumab ABthrax	Bacterial	Infection
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .

HY-P99551

Tosatoxumab KBSA301; AR-301	Antibiotic	Infection
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes *alpha-toxin* (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent .

HY-P99583

Suvratoxumab MEDI4893	Bacterial	Infection Inflammation/Immunology
Suvratoxumab (MEDI4893) is a long-acting, high-affinity *human anti-α-toxin* monoclonal antibody** (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394) .

HY-P99800

Pritoxaximab	Inhibitory Antibodies	Infection
Pritoxaximab is an IgG1κ antibody targeting shiga toxin type 1 .

HY-P99447

Atidortoxumab	Bacterial	Infection
Atidortoxumab is a human IgG1κ monoclonal antibody that targets Staph aureus alpha toxin .

HY-P99532

Urtoxazumab HuVTm1.1; TMA-15	Inhibitory Antibodies	Infection
Urtoxazumab (TMA-15) is a humanizedized monoclonal antibody against *Shiga toxin* (Stx) 2** .

HY-P99898

Setoxaximab	Bacterial	Others
Setoxaximab is an IgG1-κ humanized chimeric antibody targeting shiga toxin type 1 .

HY-P990943

Siltartoxatug	Inhibitory Antibodies	Inflammation/Immunology
HY-P990943 is an tetanus toxin-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-111965

PF-06647263 anti-EFNA4-ADC	Antibody-Drug Conjugates (ADCs) DNA Alkylator/Crosslinker Antibiotic Apoptosis	Cancer
PF-06647263 is an ADC targeting EFNA4, consisting of EFNA4 Antibody (HY-P991109), ADC toxin Calicheamicin (HY-19609) and a linker. PF-06647263 exhibits anti-tumor activity and induces significant tumor regression in TNBC xenografts .

HY-P9932

Obiltoxaximab ETI 204	Bacterial	Infection Cardiovascular Disease
Obiltoxaximab (ETI 204) is the second and potent anti-protective antigen (PA) monoclonal antibody with immunogenicity. Obiltoxaximab plays a central role in anthrax toxin assembly and target cell intoxication, promoting survival, and inhibiting bacterial spread to the periphery in animal models. Obiltoxaximab can be used in the research of inhalational anthrax, bacteremia and toxemia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P2031

Phallacidin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Arp2/3 Complex
Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin .

HY-W001117

3,5-Dimethoxyphenol Phloroglucinol Dimethyl Ether	Schisandra sphenanthera Rehd. et Wils Monophenols Classification of Application Fields Source classification Taxaceae Phenols Metabolic Disease Plants Schisandraceae Disease Research Fields Taxus chinensis (Pilger) Rehd.	Endogenous Metabolite
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

HY-N5121

Calycanthine 1 Publications Verification	Alkaloids Structural Classification Source classification Calycanthacerae Plants Chimonanthus praecox (L.)Link Alkaloid Dimers	Endogenous Metabolite
Calycanthine, the principal alkaloid of the order Calycanthaceae, has been isolated from a species of the genus Psychotria, and is a central nervous system toxin, causing convulsions .

HY-W416250

p-Cresol glucuronide	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Drug Metabolite
p-Cresol glucuronide, a metabolite of p-cresol, is a prototype protein-bound uremic toxin. p-Cresol glucuronide is associated with chronic kidney disease (CKD) .

HY-N14936

*AK-toxin* Ⅰ**	Structural Classification Natural Products Microorganisms Ketones, Aldehydes, Acids Source classification	Fungal
AK-toxin I is a host-specific phytotoxic metabolite. AK-toxin I causes black spot disease of pear trees .

HY-130067

Lolitrem B	Structural Classification Natural Products Gramineae Source classification Plants Lolium perenne L.	Antibiotic
Lolitrem B is a toxin produced by the fungus Epichloe .

HY-122191

*AK-Toxin* II**	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
AK-Toxin II is a phytotoxic metabolite that can be isolated from culture broth of alternaria alternata Japanese pear pathotype. AK-Toxin II induces characteristic veinal necrosis and rapid K ⁺ loss on susceptible pear leaves .

HY-126484

Eremofortin B	Structural Classification Natural Products Microorganisms Source classification	Fungal
Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT) .

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

HY-N6720

T-2 Triol	Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t_1/2λz), Peak plasma concentrations (C_max) and T_max values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .

HY-N13916

Alternaric acid	Structural Classification Natural Products Microorganisms Source classification	Fungal
Alternaric acid is a host-specific toxin produced by the plant fungal. In the presence of Ca ²⁺ and Mg ²⁺, Alternaric acid stimulates phosphorylation of His-tagged cytosolic kinase RiCDPK2 .

HY-N10546

Ganglioside GM1	Structural Classification Natural Products Animals	Others
Ganglioside GM1 is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 is a functional tissue receptor for the Cholera Toxin1 .

HY-N2346

Tubulysin E	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7049

Tubulysin F	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7052

Tubulysin I	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7053

Tubulysin M	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7050

Tubulysin G	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2348

Tubulysin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2347

Tubulysin C	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7051

Tubulysin H	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N9947

Methyl-6-gingerol	Structural Classification Natural Products Source classification Aframomum melegueta K.Schum. Plants Zingiberaceae	Bacterial Antibiotic
Methyl-6-gingerol is an antimicrobial agent derived from Aframomum melegueta that exhibits anti-mycobacterial activity by inhibiting the efflux of toxins within Mycobacterium species .

HY-W674241A

4-Ethylphenyl sulfate sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Ethylphenyl sulfate sodium is a gut microbial metabolite. 4-Ethylphenyl sulfate sodium is also a protein-bound uremic toxin, a xenobiotic substrate, and causes endothelial dysfunction .

HY-N6774

Cytochalasin C 1 Publications Verification	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	Others
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D .

HY-N7719

Oosporein	Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Other Diseases Benzene Quinones Disease Research Fields	Endogenous Metabolite
Oosporein is a red crystalline metabolite produced by a toxin-producing strain of Chaetomium trilaterale. Chaetomium trilaterale is isolated from moldy Peanuts. Oosporein inhibits plant growth and produces phytotoxic effects .

HY-W015343

3-Methoxyphenylacetic acid m-Methoxyphenylacetic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot .

HY-N2387

Pinosylvin	Infection Structural Classification Stilbenes Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants Disease Research Fields	Bacterial Apoptosis Autophagy
Pinosylvin is a?pre-infectious stilbenoid toxin?isolated from the heartwood of Pinus species, has anti-bacterial activities . Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells .

HY-111431A

p-Cresyl sulfate potassium 5 Publications Verification p-Tolyl sulfate potassium	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite JNK p38 MAPK
p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity .

HY-121226

Karakin	Source classification Astragalus canadensis var. mortonii (Nutt.) S.Watson Plants Fabaceae	Biochemical Assay Reagents
Karakin is a nitro toxin derived from Lotus pedunculatus. Karakin is hydrolysed rapidly to 3-NPA in gut tissue of grass grub larvae, which is enzymic and occurred mainly in the upper half of the digestive tract .

HY-119412

Biliatresone	Structural Classification Flavonoids other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Isoflavones	Reactive Oxygen Species
Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model .

HY-N11667

18-O-Demethylpederin	Structural Classification Natural Products Source classification Marine natural products Other marine organisms	Others
18-O-Demethylpederin is a pederin analogue. Pederin is a natural polyketide compound extracted from Paederus for the first time. It is a non-protein insect toxin with a broad spectrum of biological activities, including antibacterial, antiviral, and antitumor .

HY-111009

Swinholide A	Infection Structural Classification Natural Products Classification of Application Fields Animals Source classification Marine natural products Sponge Disease Research Fields	Fungal
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-N10511

GM1a Ganglioside oligosaccharide	Structural Classification Natural Products Polysaccharides Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Others
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses .

HY-126645

Atelopidtoxin	Structural Classification Natural Products Animals Source classification Animal Venoms	Sodium Channel
Atelopidtoxin (zetekitoxin) is a toxin (LD₅₀=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .

HY-P3065

Calcicludine	Structural Classification Natural Products Animals Source classification	Calcium Channel
Calcicludine is a protein toxin from the venom of the green mamba Dendroaspis angusticeps that inhibits high-voltage-activated calcium channel, especially L-type calcium channel with the IC₅₀ of 88 nM. Calcicludine has role in excitatory synaptic transmission .

HY-N6688

Verruculogen	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Potassium Channel Bacterial Antibiotic
Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca ²⁺-activated K ⁺ channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle .

HY-P3003

Cereulide	Microorganisms Source classification	Apoptosis
Cereulide, a toxin depsipeptide, can be produced by Bacillus cereus. Cereulide induces cell apoptosis. Cereulide acts on mitochondria, leading to dysfunction in different organs (liver, pancreatic islet, brain, intestines, etc.) and body systems (immune system and nervous system) .

HY-N2802

Euptox A 9-Oxo-10,11-dehydroageraphorone	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Derris indica	Apoptosis Caspase Parasite
Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells .

HY-W040307B

Saccharopine hydrochloride L-Saccharopine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis .

HY-N13151

3-GlcA-28-AraRhaxyl-medicagenate	Structural Classification Polysaccharides Leguminosae Source classification Plants Medicago truncatula Gaertn. Saccharides	Fungal
3-GlcA-28-AraRhaxyl-medicagenate is an insect toxin belonging to the saponin family. 3-GlcA-28-AraRhaxyl-medicagenate exhibits antifungal activity and causes mortality in rice weevils at doses down to 0.1 mg/mL .

HY-P0190

Iberiotoxin 1 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Potassium Channel
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca ²⁺-activated K ⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels .

HY-107222

Lysionotin	Gesneriaceae Structural Classification Lysinonotus pauciflorus Maxim. Flavonoids Classification of Application Fields Flavones Source classification Plants Inflammation/Immunology Disease Research Fields	Bacterial
Lysionotin is a flavonoid isolated from Gesneriaceae family. Lysionotin efficiently inhibit *α-Toxin* (a pore-forming protein) expression and shows significant protection against S. aureus in vitro and in vivo. Lysionotin has the potential for the treatment of S. aureus induced pneumonia .

HY-W040307

Saccharopine L-Saccharopine	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis .

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-122009

Indican Indoxyl-β-D-glucoside	Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids Indigofera	P-glycoprotein OAT Fluorescent Dye
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .

HY-169871

Argiotoxin 636	Structural Classification Animals Source classification Phenols Polyphenols Animal Venoms	iGluR
Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases .

HY-W145518

Pectin	Infection Structural Classification Polysaccharides Malus pumila Mill. Source classification Rosaceae Plants Saccharides	Endogenous Metabolite Bacterial Antibiotic
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa .

HY-W012479

H-D-Trp-OH 1 Publications Verification D-Tryptophan	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-D-Trp-OH (D-Tryptophan) is the D-isomer of tryptophan, which is occasionally found in natural peptides, such as marine toxin peptides. H-D-Trp-OH can increase intestinal microbial diversity and counteract the inhibitory effect of allergic airway inflammation on intestinal microbial diversity .

HY-N2387R

Pinosylvin (Standard)	Structural Classification Stilbenes Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants	Bacterial Apoptosis Autophagy
Pinosylvin (Standard) is the analytical standard of Pinosylvin. This product is intended for research and analytical applications. Pinosylvin is a pre-infectious stilbenoid toxin isolated from the heartwood of Pinus species, has anti-bacterial activities . Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells .

HY-N6745

Citreoviridin	Cardiovascular Disease Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Na+/K+ ATPase Apoptosis
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-129209

Myrotoxin B	Structural Classification Natural Products Source classification Morus alba L. Plants Moraceae	Others
Myrotoxin B is a toxin produced by the fungus Myrothecium roridum that can induce necrotic lesions in mulberry leaves. Myrotoxin B can also promote the infection rate of Myrothecium roridum, acting as an infection factor, increasing the ability of the fungus to infect host plants. Myrotoxin B can be used in plant pathology and mycotoxin research .

Cat. No.	Product Name	Chemical Structure

HY-111431AS

p-Cresol sulfate-d7 potassium
p-Cresol sulfate-d₇ (potassium) is the deuterium labeled p-Cresyl sulfate potassium. p-Methylphenyl potassium sulfate is a prototype protein-bound uremic toxin[1][2].

HY-Z0056S

Bromobenzene-d5
Bromobenzene-d₅ is the deuterium labeled Bromobenzene. Bromobenzene is a well-known environmental toxin which causes liver and kidney damage through CYP450-mediated bio-activation to generate reactive metabolites and, consequently, oxidative stress[1].

HY-136406S

Bongkrekic acid-13C28

Bongkrekic acid- ¹³C₂₈ is the ¹³C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .

HY-103447S1

Zearalenone-13C18
Zearalenone- ¹³C₁₈ (Mycotoxin F2- ¹³C₁₈; Toxin F2- ¹³C₁₈) is the ¹³C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-23155S

2-Phenylethyl isothiocyanate-d5

2-Phenylethyl isothiocyanate-d₅ isothiocyanate-d₅ is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].

HY-42682S1

D(+)-Galactosamine-13C hydrochloride
D(+)-Galactosamine- ¹³C (hydrochloride) is the ¹³C labeled D(+)-Galactosamine hydrochloride. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and

HY-107654S

Muscarine-d9 iodide
Muscarine-d₉ (iodide) is the deuterium labeled Muscarine iodide. Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist[1][2].

HY-W654121

p-Cresol sulfate-d4 potassium
p-Cresol sulfate-d₄ (potassium) is deuterium labeled p-Cresyl sulfate (potassium). p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity .

HY-N6801S

Nivalenol-13C15

Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

HY-W015912S

2-Acetylfuran-d3

2-Acetylfuran-d₃ is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-B1455S

Clindamycin-d3 hydrochloride

Clindamycin-d₃ (hydrochloride) is the deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2].

HY-B1455S1

Clindamycin-13C,d3

Clindamycin- ¹³C,d₃ is the ¹³C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2][3].

Cat. No.	Product Name		Classification

HY-126690

DBCO-(PEG2-VC-PAB-MMAE)2		DBCO
DBCO-(PEG2-VC-PAB-MMAE)2 is made by MMAE conjugated to the cleavable DBCO-(PEG2-VC-PAB)2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody agent conjugate . DBCO-(PEG2-VC-PAB-MMAE)2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Cat. No.	Product Name		Classification