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Results for "

IV

" in MedChemExpress (MCE) Product Catalog:

302

Inhibitors & Agonists

9

Fluorescent Dye

12

Biochemical Assay Reagents

34

Peptides

3

Inhibitory Antibodies

52

Natural
Products

65

Recombinant Proteins

13

Isotope-Labeled Compounds

23

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155888
    IV-255

    		Epigenetic Reader Domain Cancer
    IV-255 is a selective small molecule inhibitor of the BRG1 bromodomain. IV-255 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345). IV-255 inhibits the invasiveness of GBM cells. IV-255 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide .
    IV-255
  • HY-139011
    IV-361

    		CDK Cancer
    IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1) .
    IV-361
  • HY-13734
    PX-12
    5+ Cited Publications

    IV-2

    		 Others Cancer
    PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively.
    PX-12
  • HY-E70397
    Dipeptidyl peptidase IV

    DPP-IV

    		 Others Metabolic Disease Cancer
    Dipeptidyl peptidase IV (DPP-IV) is a protease that inactivates insulin stimulating hormones such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulin-like polypeptide (GIP). Dipeptidyl peptidase IV can be used as a binding protein and ligand for various extracellular molecules. Dipeptidyl peptidase IV can be used in diabetes research .
    Dipeptidyl peptidase IV
  • HY-155889
    IV-275

    		Epigenetic Reader Domain Cancer
    IV-275 is an inhibitor of both BRG1 and BRM bromodomains. IV-275 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345). IV-275 inhibits the invasiveness of GBM cells. IV-275 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide .
    IV-275
  • HY-126324
    IV-23

    		Apoptosis Cancer
    IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC) .
    IV-23
  • HY-W127360
    Sialyl Neolactotetraosylceramide

    Sialyl nLc4Cer; IV3NeuAcnLc4Cer

    		 Biochemical Assay Reagents Others
    Sialyl Neolactotetraosylceramide (=Sialyl nLc4Cer) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Sialyl Neolactotetraosylceramide
  • HY-P5184
    Hainantoxin-IV

    HNTX-IV

    		 Sodium Channel Neurological Disease
    Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .
    Hainantoxin-IV
  • HY-N9371R
    Crocin IV (Standard)

    		Endogenous Metabolite Others
    Crocin IV (Standard) is the analytical standard of Crocin IV. This product is intended for research and analytical applications. Crocin IV (Dicrocin), a crocetin glycoside, is a carotenoid pigment. Crocin IV has potent antioxidant activity .
    Crocin IV (Standard)
  • HY-P5868
    mHuwentoxin-IV

    		Sodium Channel Neurological Disease
    mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC50 of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages .
    mHuwentoxin-IV
  • HY-125131
    Buddlejasaponin IV

    		NO Synthase COX Inflammation/Immunology Cancer
    Buddlejasaponin IV (BS‐IV) exerts anti-inflammatory and cytotoxic effects against cancer cells .
    Buddlejasaponin IV
  • HY-D1896
    Chloride Ionophore IV

    		Fluorescent Dye Others
    Chloride Ionophore IV is a thiourea type hydrogen bonding-based receptor. Chloride Ionophore IV is a chloride ionophore .
    Chloride Ionophore IV
  • HY-N8760
    Batatasin IV

    		Aminopeptidase Inflammation/Immunology
    Batatasin IV is an LTA4H inhibitor with anti-inflammatory activity. Batatasin IV is also a natural product that can be obtained from Dioscorea batatus. Batatasin IV can be used in research in the area of inflammation .
    Batatasin IV
  • HY-119244
    Gly-Pro-pNA hydrochloride

    		Dipeptidyl Peptidase Others
    Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors .
    Gly-Pro-pNA hydrochloride
  • HY-P5654
    Bombolitin IV

    		Bacterial Infection
    Bombolitin IV is an antimicrobial peptide derived from bumblebee venom. Bombolitin IV can lysate erythrocyte and liposome .
    Bombolitin IV
  • HY-E70005D
    Collagenase IV, Clostridium histolytica

    Collagenase, Type IV

    		 MMP Others
    Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin.
    Collagenase IV, Clostridium histolytica
  • HY-10025
    (S)-SW IV-52 hydrochloride

    		Apoptosis Cancer
    (S)-SW IV-52 hydrochloride is a small molecule that can induce apoptosis in ovarian cancer. (S)-SW IV-52 hydrochloride has minimal single-agent activity at concentrations up to 200 μM .
    (S)-SW IV-52 hydrochloride
  • HY-N9328
    Tarasaponin IV

    		Others Cancer
    Tarasaponin IV, as an oleanane-type triterpene saponin, is isolated from the bark of Aralia elata. Tarasaponin IV can be used for the research of cancer .
    Tarasaponin IV
  • HY-148035
    Plm IV inhibitor-2

    		Parasite Infection
    Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV (Plm IV) inhibitor with IC50 values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium parasites .
    Plm IV inhibitor-2
  • HY-N11010
    Eclalbasaponin IV

    		Others Cancer
    Eclalbasaponin IV is a triterpenoid that can be isolate from the aerial parts of Eclipta prostrata. Eclalbasaponin IV shows antitumor activity in human ovarian cancer cells .
    Eclalbasaponin IV
  • HY-N12069
    Praeroside IV

    		Others Inflammation/Immunology
    Praeroside IV can be isolated from the roots of Angelica furcijuga. Praeroside IV can be used for research of D-GalN/LPS-induced liver injury .
    Praeroside IV
  • HY-N9371
    Crocin IV

    Dicrocin

    		 Endogenous Metabolite Others
    Crocin IV (Dicrocin), a crocetin glycoside, is a carotenoid pigment. Crocin IV has potent antioxidant activity .
    Crocin IV
  • HY-157185
    Etioporphyrin IV acid

    		Others Others
    Etioporphyrin IV acid is a hapten that can be coupled with bovine serum albumin and keyhole limpet hemocyanin. Etioporphyrin IV acid can target porphyrin with IC50 of 1.3 μM .
    Etioporphyrin IV acid
  • HY-N8216
    Bacopaside IV

    		Others Neurological Disease
    Bacopaside IV is a saponin .
    Bacopaside IV
  • HY-148034
    Plm IV inhibitor-1

    		Others Infection
    Plm IV inhibitor-1 (compound 6) is a potent plasmepsin IV (Plm IV) inhibitor with IC50s of 4.1, 0.80, 0.25, 0.35 µM for Plm I, Plm II, Plm IV, Cat D, respectively .
    Plm IV inhibitor-1
  • HY-D0932R
    Sudan IV (Standard)

    		Fluorescent Dye Others
    Sudan IV (Standard) is the analytical standard of Sudan IV. This product is intended for research and analytical applications. Sudan IV (Solvent Red 24) is a lysochrome (fat-soluble dye) diazo dye used for the staining of lipids, triglycerides and lipoproteins on frozen sections .
    Sudan IV (Standard)
  • HY-N13579
    Momordicin IV

    		Others
    Momordicin IV is a natural product .
    Momordicin IV
  • HY-N5076
    Picfeltarraenin IV

    		Cholinesterase (ChE) Infection Inflammation/Immunology Cancer
    Picfeltarraenin IV, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IV can be used for the treatment of herpes infections, cancer and inflammation .
    Picfeltarraenin IV
  • HY-N8804
    Shatavarin IV

    Asparanin B

    		 Reactive Oxygen Species Neurological Disease Cancer
    Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans .
    Shatavarin IV
  • HY-N6945R
    Mogroside IV (Standard)

    		Others Metabolic Disease Cancer
    Mogroside IV (Standard) is the analytical standard of Mogroside IV. This product is intended for research and analytical applications. Mogroside IV, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .
    Mogroside IV (Standard)
  • HY-N7483
    1-Dehydroxybaccatin IV

    		Others Metabolic Disease
    1-Dehydroxybaccatin IV is a taxane diterpene. 1-Dehydroxybaccatin IV shows concentration-dependent NO inhibition, with an IC50 of 32.2 μM .
    1-Dehydroxybaccatin IV
  • HY-U00352
    PDE IV-IN-1

    		Phosphodiesterase (PDE) Inflammation/Immunology
    PDE IV-IN-1 is an inhibitor of phosphodiesterase IV, used for the research of asthma, COPD or other inflammatory diseases.
    PDE IV-IN-1
  • HY-W783917
    Lead Ionophore IV

    		Others
    Lead Ionophore IV is an ionophore that has the activity of promoting metal ion transport. Lead Ionophore IV is often used in biological research to study the biological effects of lead ions and their effects on cell function. Lead Ionophore IV can also be used to develop drug delivery systems to improve the bioavailability of compounds.
    Lead Ionophore IV
  • HY-N4214
    Isoastragaloside IV

    		Others Others
    Isoastragaloside IV is a triterpene oligoglycoside isolated from Astragali Radix.
    Isoastragaloside IV
  • HY-N0431R
    Astragaloside IV (Standard)

    		MMP ERK JNK Cancer
    Astragaloside IV (Standard) is the analytical standard of Astragaloside IV. This product is intended for research and analytical applications. Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
    Astragaloside IV (Standard)
  • HY-N8693
    Withanoside IV

    		Others Others
    Withanoside IV is a Steroids product that can be isolated from the herbs of Withania somnifera .
    Withanoside IV
  • HY-N6014
    Asperosaponin IV

    		Others Others
    Asperosaponin IV is a Triterpenoids product that can be isolated from the roots of Dipsacus asperoides .
    Asperosaponin IV
  • HY-P1220
    Huwentoxin-IV

    		Sodium Channel Neurological Disease
    Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain .
    Huwentoxin-IV
  • HY-N5086
    Picroside IV

    		HBV Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .
    Picroside IV
  • HY-P4018
    HIV Protease Substrate IV

    		HIV Protease Infection
    HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease .
    HIV Protease Substrate IV
  • HY-115394
    Soyasaponin IV

    		Others Others
    Soyasaponin IV, isolated from the aerial parts of Glycine soya, exhibits a hepatoprotective action .
    Soyasaponin IV
  • HY-115990
    Topoisomerase IV inhibitor 1

    		Topoisomerase Bacterial Infection
    Topoisomerase IV inhibitor 2 (compound 7d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.23 μM and 0.43 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 0.972 μM and 0.608 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively .
    Topoisomerase IV inhibitor 1
  • HY-115991
    Topoisomerase IV inhibitor 2

    		Topoisomerase Bacterial Infection
    Topoisomerase IV inhibitor 2 (compound 5d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC50s of 0.35 μM and 0.55 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 1.985 μM and 0.744 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively .
    Topoisomerase IV inhibitor 2
  • HY-151578
    DPP IV/hCA II-IN-1

    		Dipeptidyl Peptidase Carbonic Anhydrase Metabolic Disease
    DPP IV/hCA II-IN-1 is a potent and selective dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA) inhibitor with an IC50 value of 0.049 μM for DPP IV and with Ki values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively .
    DPP IV/hCA II-IN-1
  • HY-108319
    DPP-IV-IN-2

    		Dipeptidyl Peptidase Neurological Disease Inflammation/Immunology
    DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV (DPIV) and DP8/9 with IC50s of 0.1 and 0.95 μM, respectively.
    DPP-IV-IN-2
  • HY-U00346
    TS-021 free base

    DPP-IV-IN-1

    		 Dipeptidyl Peptidase Metabolic Disease
    DPP-IV-IN-1 is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), a highly specific serine protease, with an IC50 of 4.6 nM.
    TS-021 free base
  • HY-69317
    RS14203

    PMNPQ

    		 Phosphodiesterase (PDE) Others
    RS14203 is an orally active type IV cyclic nucleotide phosphodiesterase (PDE IV) inhibitor which can induce emesis .
    RS14203
  • HY-P1220A
    Huwentoxin-IV TFA

    		Sodium Channel Neurological Disease
    Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain .
    Huwentoxin-IV TFA
  • HY-108254
    Bisindolylmaleimide IV

    Arcyriarubin A

    		 PKC CMV Infection
    Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM) . Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM .
    Bisindolylmaleimide IV
  • HY-101335
    DCG-IV

    		mGluR Neurological Disease
    DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects .
    DCG-IV

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