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Pathways Recommended:	PROTAC

Results for "

Ligand for Target Protein for PROTAC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (16) Ligands for E3 Ligase (16) Ligands for Target Protein for PROTAC (162) PD-1/PD-L1 (2) PROTAC Linkers (10) Target Protein Ligand-Linker Conjugates (9) 17β-HSD (1) AAK1 (1) Acetyl-CoA Carboxylase (1) ADC Linker (1) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (5) Apoptosis (23) Aurora Kinase (7) Autophagy (5) Bcl-2 Family (1) BCL6 (1) Bcr-Abl (2) Btk (11) c-Met/HGFR (1) c-Myc (4) CaMK (1) Casein Kinase (3) CDK (16) CRM1 (2) Cyclophilin (2) Cytochrome P450 (1) Dengue Virus (1) DNA Methyltransferase (1) DNA/RNA Synthesis (4) DYRK (1) Early 2 Factor (E2F) (1) EGFR (5) Epigenetic Reader Domain (47) Estrogen Receptor/ERR (9) FAK (3) Ferroptosis (4) FGFR (4) FKBP (5) Flavivirus (1) FLT3 (4) Glutathione Peroxidase (3) HCV (1) HDAC (10) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) Histone Demethylase (2) Histone Methyltransferase (4) HIV (2) HSP (1) IKK (1) IKZF Family (1) Indoleamine 2,3-Dioxygenase (IDO) (1) IRAK (3) Itk (3) JAK (1) JNK (1) Kinesin (2) LIM Kinase (LIMK) (1) MAP3K (1) MAP4K (1) MDM-2/p53 (4) MEK (2) Mixed Lineage Kinase (2) Mps1 (2) mTOR (1) NAMPT (1) NF-κB (1) p38 MAPK (2) PARP (2) Phosphatase (1) PI3K (1) PIN1 (2) Polo-like Kinase (PLK) (1) PROTACs (171) Proteasome (1) Raf (1) Ras (5) RET (4) RIP kinase (2) ROR (1) Salt-inducible Kinase (SIK) (1) SARS-CoV (4) Sirtuin (1) STAT (6) STING (3) SWI/SNF Complex (3) Tau Protein (2) Tyrosinase (1) ULK (1) Virus Protease (4) WDR5 (2) Wnt (1) YAP (4) α-synuclein (1) β-catenin (1)
By Research Areas:	Cancer (357) Cardiovascular Disease (1) Endocrinology (1) Infection (13) Inflammation/Immunology (12) Metabolic Disease (5) Neurological Disease (6)
Click Chemistry:	PROTAC Synthesis (3) Azide (20) Alkynes (5)

395

Inhibitors & Agonists

Screening Libraries

Peptides

Click Chemistry

Targets Recommended: Ligands for Target Protein for PROTAC PROTAC-Linker Conjugates for PAC Target Protein Ligand-Linker Conjugates PROTAC Linkers E3 Ligase Ligand-Linker Conjugates Ligands for E3 Ligase Drug-Linker Conjugates for ADC PD-1/PD-L1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-168970

MT2A ligand 1	Ligands for Target Protein for PROTAC	Cancer
MT2A ligand 1 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). MT2A ligand 1 can be used for synthesis AA-BR-157 (HY-168969) .

HY-44824

SMARCA2 ligand-13	Epigenetic Reader Domain Ligands for Target Protein for PROTAC	Cancer
SMARCA2 ligand-13 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMARCA2 ligand-13 can be used for synthesis PROTACs .

HY-169487

SMARCA2 ligand-12	Epigenetic Reader Domain Ligands for Target Protein for PROTAC	Cancer
SMARCA2 ligand-12 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMARCA2 ligand-12 can be used for synthesis PROTAC SMARCA2 degrader-25 (HY-169276) .

HY-168691

PTPN2 ligand 1	Ligands for Target Protein for PROTAC	Cancer
PTPN2 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). PTPN2 ligand 1 can be used to synthesize PVD-06 (HY-149760) .

HY-168283

HPK1 ligand 2	Ligands for Target Protein for PROTAC	Cancer
HPK1 ligand 2 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). HPK1 ligand 2 can be used for synthesis DD205-291 (HY-168282) .

HY-170303

AR ligand-32	Ligands for Target Protein for PROTAC	Cancer
AR ligand-32 is a target protein ligand, used for the synthesis of PROTAC AR Degrader-7 (HY-160221) .

HY-169396

TAE648	Ligands for Target Protein for PROTAC	Cancer
TAE648 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC SK-3-91 (HY-137341) .

HY-168685

c-Myc ligand 1	c-Myc Ligands for Target Protein for PROTAC	Cancer
c-Myc ligand 1, a c-Myc inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). c-Myc ligand 1 can be used for synthesis PROTAC c-Myc inhibitor 7 (HY-148837) .

HY-168671

pan-KRAS ligand 1	Ligands for Target Protein for PROTAC Ras	Cancer
pan-KRAS ligand 1 is a **Ligand for Target Protein for PROTAC*. pan-KRAS ligand* 1 can be used for synthesis PROTAC pan-KRAS degrader 4 (HY-168669) .

HY-168271

ER ligand-2	Ligands for Target Protein for PROTAC Estrogen Receptor/ERR	Cancer
ER ligand-2 (Ligands for Target Protein for Compound 24) is the ligand of ER. ER ligand-2 can be used for synthesis PROTAC ER Degrader-11 (HY-168270) .

HY-168700

G12D ligand 1	Ligands for Target Protein for PROTAC	Cancer
G12D ligand 1 is a **Ligand for Target Protein for PROTAC*. G12D ligand* 1 can be used to synthesize Setidegrasib (HY-148273) .

HY-168611

PROTAC IRAK4 ligand-4	Ligands for Target Protein for PROTAC IRAK	Cancer
PROTAC IRAK4 ligand-4 is a **Ligand for Target Protein for PROTAC** with antitumor activity. PROTAC IRAK4 ligand-4 can be used to synthesize PROTAC IRAK4 degrader-12 (HY-168586) .

HY-170817

SMI-1074	Ligands for Target Protein for PROTAC	Cancer
SMI-1074 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMI-1074 can be used for synthesis SMD-3236 (HY-170824) and SMD-1087 (HY-170828) .

HY-168275

TRIB2 ligand-1	Ligands for Target Protein for PROTAC	Cancer
TRIB2 ligand-1 is a ligand of TRIB2 (Ligands for Target Protein for PROTACs). TRIB2 ligand-1 can be used for synthesis PROTAC TRIB2 degrader-1 (HY-168274) .

HY-168638

PROTAC SOS1 ligand 1	Ligands for Target Protein for PROTAC	Cancer
PROTAC SOS1 ligand 1, a BI-3406 (HY-125817) analog, is a ligand for target SOS1 protein for PROTACT SIAIS562055 (HY-168637) .

HY-169379

CSI118 TFA	Ligands for Target Protein for PROTAC	Cancer
CSI118 TFA (Compound 1) is a **Ligand for Target Protein for PROTAC**. CSI118 TFA can be used to synthesize CSI86 (HY-169378) .

HY-168702

FLT3 ligand-2	Ligands for Target Protein for PROTAC	Cancer
FLT3 ligand-2 is a **Ligand for Target Protein for PROTAC*. FLT3 ligand-2 can be used to synthesize PROTAC* FLT-3 degrader 1 (HY-114323) .

HY-168695

BRD9 ligand-7	Ligands for Target Protein for PROTAC	Cancer
BRD9 ligand-7 is a **Ligand for Target Protein for PROTAC**. CSI118 TFA can be used to synthesize BRD9 Degrader-1 (HY-156401) .

HY-168288

MEK ligand-2	MEK Ligands for Target Protein for PROTAC	Cancer
MEK ligand-2, a MEK1 and MEK2 inhibitor, is a ligand for target protein for PROTAC of MS934 (HY-153863). MS934 is a VHL-recruiting MEK 1/2 PROTAC degrader .

HY-47709

STING ligand-3	Ligands for Target Protein for PROTAC	Inflammation/Immunology
STING ligand-3 is a **Ligand for Target Protein for PROTAC** activity control. STING ligand-3 can be used to synthesize Anti-inflammatory agent 70 (HY-157570) .

HY-159956

BTK-IN-39	Ligands for Target Protein for PROTAC	Cancer
BTK-IN-39 (0204) is a PROTAC target protein ligand that can be used to synthesize PROTAC BTK Degrader-11 (HY-159947) .

HY-134725

MTH1 degrader-1	DNA/RNA Synthesis Ligands for Target Protein for PROTAC	Cancer
MTH1 degrader-1, a MTH1 aTAG inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). MTH1 degrader-1 can be used for synthesis PROTAC aTAG 4531 (HY-163168) .

HY-130979

EED226-COOH	Ligands for Target Protein for PROTAC	Cancer
EED226-COOH is an EED226-derived ligand for target protein EED ligand for PROTAC, binds to a ligand for VHL via linker to form UNC6852 (HY-130708) to degrade PRC2 .

HY-170326

HSP90-IN-35	Ligands for Target Protein for PROTAC HSP	Cancer
Hsp90-in-35 (Compound 379) is an inhibitor of Hsp90. The IC₅₀ of HSP90-IN-35 for Her2 is between 0.05 and 0.5 μM. HSP90-IN-35 has antitumor activity. HSP90-IN-35 can be used to synthesize PROTAC (HY-153881) .

HY-168230

SMARCA2 ligand-9	Ligands for Target Protein for PROTAC	Cancer
SMARCA2 ligand-9 is the ligand of SMARCA2. SMARCA2 ligand-9 can be used to synthesize PROTAC SMARCA2 degrader-27 (HY-168229) .

HY-168683

CDK8 ligand 1	Ligands for Target Protein for PROTAC CDK	Cancer
CDK8 ligand 1 is the ligand of CDK8. CDK8 ligand 1 can be used to synthesize LL-K8-22 (HY-149209) .

HY-168302

BTK ligand 10	Ligands for Target Protein for PROTAC Tyrosinase Btk	Cancer
BTK ligand 10 is the ligand of BTK. BTK ligand 10 can be used to synthesize (R)-NX-2127 (HY-153220A) .

HY-75578

dTAG Targeting Ligand 1	Polo-like Kinase (PLK) Ligands for Target Protein for PROTAC	Cancer
dTAG Targeting Ligand 1 (SUBSTITUTE SHEET 245) is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). dTAG Targeting Ligand 1 can be used for synthesis PROTACs .

HY-168311

PROTAC IRAK4 ligand-5	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-5 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC IRAK4 ligand-5 can be utilized for the synthesis of KT-413 (HY-153368) .

HY-49421

BTK ligand 12	Ligands for Target Protein for PROTAC	Cancer
BTK ligand 12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BTK ligand 12 can serve as an active control for the target protein ligand of NRX-0492 (HY-153357) .

HY-162876

PROTAC BRD4 ligand-3	Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4 ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC BRD4 ligand-3 can be used for synthesis PROTAC BRD4 Degrader-27 (HY-162875) .

HY-168387

ITK ligand 1	Ligands for Target Protein for PROTAC Itk	Cancer
ITK ligand 1 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). ITK ligand 1 can be used in the synthesis of PROTACs (e.g. HY-149917) .

HY-169978

ER ligand-3	Ligands for Target Protein for PROTAC	Cancer
ER ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). ER ligand-3 can be used for the synthesis of PROTAC ER Degrader-12 (HY-160264) .

HY-168038

PIN1 ligand-1	Ligands for Target Protein for PROTAC	Cancer
PIN1 ligand-1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PIN1 ligand-1 can be used for synthesis PROTAC PIN1 degrader-1 (HY-168037) .

HY-48932

IRAK4 ligand-12	Ligands for Target Protein for PROTAC	Cancer
IRAK4 ligand-12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). IRAK4 ligand-12 can be used for the synthesis of KTX-951 (HY-148290) .

HY-161990

BCL6 ligand-2	Ligands for Target Protein for PROTAC	Cancer
BCL6 ligand-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BCL6 ligand-2 can be used for synthesis DZ-837 (HY-161989) .

HY-49393

BRD9 ligand-6	Ligands for Target Protein for PROTAC	Cancer
BRD9 ligand-6 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-6 can be utilized for the synthesis of FHD-609 (HY-153367) .

HY-159573

Napabucasin analogue	Ligands for Target Protein for PROTAC	Cancer
Thalidomide acid is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Thalidomide acid can be used in synthesis Napabucasin (HY-13919) .

HY-169482

ALK protein ligand-1	Ligands for Target Protein for PROTAC Anaplastic lymphoma kinase (ALK)	Cancer
ALK protein ligand-1 (Compound A1), a ligand for the anaplastic lymphoma kinase (ALK) protein, is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) that exhibits inhibitory effects on ALK. ALK protein ligand-1 can be used in the synthesis of AP-1 (HY-169481) .

HY-169049

Smurf1 ligand 1	Ligands for Target Protein for PROTAC	Cancer
Smurf1 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Smurf1 ligand 1 can be used for synthesis SMART1 (HY-W998345) .

HY-162841

HPK1 ligand 1	Ligands for Target Protein for PROTAC	Cancer
HPK1 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). HPK1 ligand 1 can be used for synthesis PROTAC PD-L1 degrader-2 (HY-162816) .

HY-168017

NSC682769	Ligands for Target Protein for PROTAC	Cancer
NSC682769 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). NSC682769 can be used for synthesis PROTAC YAP degrader-1 (HY-168016) .

HY-159544

SMARCA2 ligand-7	Ligands for Target Protein for PROTAC	Cancer
SMARCA2 ligand-7 is a ligand for target protein for pROTAC.

HY-159542

SMARCA2 ligand-6	Ligands for Target Protein for PROTAC	Cancer
SMARCA2 ligand-6 is a ligand for target protein for pROTAC.

HY-169988

BRD9 ligand-5	Ligands for Target Protein for PROTAC	Cancer
BRD9 ligand-5 (Compound 172-11) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-5 can be utilized for the synthesis of CFT8634 (HY-145925B) .

HY-170354

SMARCA2/4-ligand-4	Ligands for Target Protein for PROTAC	Cancer
SMARCA2/4-ligand-4 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-4 can be used for the synthesis of PROTAC SMARCA2/4 degrader-36 (HY-170347) .

HY-132942A

PROTAC BRD4 ligand-2 hydrochloride	Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4 ligand-2 hydrochloride is a ligand for target BRD4 protein for *PROTAC* CFT-2718.

HY-132942

PROTAC BRD4 ligand-2	Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for *PROTAC* CFT-2718.

HY-162814

SMARCA2/4-ligand-3	Ligands for Target Protein for PROTAC	Cancer
SMARCA2/4-ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-3 can be used for synthesis PROTAC SMARCA2/4-degrader-25 (HY-162813) .

HY-161973

Hydroxyl-ML-210	Ligands for Target Protein for PROTAC	Cancer
Hydroxyl-ML-210 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Hydroxyl-ML-210 can be used for synthesis ZX782 (HY-161972) .

Cat. No.	Product Name

HY-L129

Target Protein Ligand Library

54 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 54 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

HY-L128

E3 Ligase Ligand Library

65 compounds

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 65 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L151

PROTAC Library

340 compounds

PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy.

MCE supplies a unique collection of 340 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

HY-L918

Molecular Glue-like Compound Library

1200 compounds

Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms.

Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases.

Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-, VHL-, and DCAF-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 1200 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

Cat. No.	Product Name	Target	Research Area

HY-169235

DHHC3 degrader 1	Ligands for Target Protein for PROTAC	Cancer
DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232) .

HY-162946

Alkyne-P60	Ligands for Target Protein for PROTAC	Cancer
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a **ligand for target protein for PROTAC** (HY-162943).

Cat. No.	Product Name		Classification

HY-163926

SMARCA2/4-IN-2		Azide
SMARCA2/4-IN-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-2 can be used for synthesis PROTAC SMARCA2/4-degrader-5 (HY-159456) .

HY-69220

7-Octynoic acid		Alkynes PROTAC Synthesis
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159544

SMARCA2 ligand-7		Azide
SMARCA2 ligand-7 is a ligand for target protein for pROTAC.

HY-159542

SMARCA2 ligand-6		Azide
SMARCA2 ligand-6 is a ligand for target protein for pROTAC.

HY-159615

Cbl-b-IN-21		Azide
Cbl-b-IN-21 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Cbl-b-IN-21 can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608) .

HY-159545

SMARCA2/4-ligand-2		Azide
SMARCA2/4-ligand-2 is a ligand for target protein for pROTAC.

HY-159164

PROTAC CRBN ligand-3		Azide
PROTAC CRBN ligand-3 is a target protein ligand of RGB110 (HY-159087).

HY-172360

HDAC6 ligand-3		Alkynes
HDAC6 ligand-3 is a ligand for HDAC6 that can be used as target protein ligand for synthesis of PROTAC HDAC6 degrader 4 (HY-172359) .

HY-163167

VH 032 amide-alkylC5-azide		Azide
VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .

HY-161132

Lenalidomide 4'-alkyl-C5-azide		Azide
Lenalidomide 4'-alkyl-C5-azide is a functionalized cerebellar ligand for PROTAC development that contains an E3 ligand and an alkyl LC5 ligand with terminal azides that can be coupled to a target protein ligand .

HY-159799

p38α inhibitor 5		Alkynes
p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand targeting p38 and can be used to synthesize NR-11c (HY-159798) .

HY-108374

4-Azidobutylamine		Azide PROTAC Synthesis
4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159608

PROTAC Cbl-b-IN-1		Azide
PROTAC Cbl-b-IN-1 (compound 64) is a PROTAC targeting Cbl-b. PROTAC Cbl-b-IN-1 is composed of PROTAC target protein ligand Cbl-b-IN-21 (HY-159615), PROTAC Linker Cbz-Pip-2C-Pip-C-Pip (HY-159617) and E3 ubiquitin ligase ligand (3S) Lenalidomide-5-Br (HY-W797329), where the E3 ubiquitin ligase ligand + Linker conjugate is (3S) Lenalidomide-5-Pip-C-Pip-2C-Pip (HY-159618) ^{[1] ^.}

HY-130296

Palbociclib-propargyl PROTAC CDK6 Ligand 1		Alkynes
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC₅₀ of 2.1 nM for CDK6 . Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159087

RGB110		Azide
RGB110 (Compound 10d) is a PROTAC inhibitor for D-dopachrome tautomerase with an IC₅₀ of 5.9 μM. RGB110 causes no degradation of D-DT. (Pink: ligand for target protein (HY-159164); Black: linker (HY-W125017); Blue: ligand for E3 ligase CRBN (HY-10984))

HY-159472

SMARCA2/4-ligand-1		Azide
2-(6-Amino-5-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)phenol is a Ligand for target protein for pROTAC.

HY-159449

PROTAC SMARCA2 degrader-5		Azide
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159451

PROTAC SMARCA2 degrader-7		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159461

PROTAC SMARCA2/4-degrader-9		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159455

PROTAC SMARCA2/4-degrader-4		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

PROTAC SMARCA2/4-degrader-5		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

PROTAC SMARCA2/4-degrader-8		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2 with DC₅₀ <100 nM in A549 and in MV411, degrades SMARCA4 with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-162946

Alkyne-P60		Alkynes
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a **ligand for target protein for PROTAC** (HY-162943).

HY-151792

Pomalidomid-C6-PEG3-butyl-N3		Azide PROTAC Synthesis
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a *crosslinker-E3 ligase ligand* conjugate*, which be used in click reactive protein* degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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