1. Gene
  2. Acly - ATP citrate lyase Gene

Acly - ATP citrate lyase Gene

Rattus norvegicus

Also known as ACL; Clatp

Gene ID: 24159 | Gene type: protein coding

About Acly

Primary_assembly 10: 85,412,049-85,463,320 reverse strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 283 orthologues and is associated with 3 phenotypes. Biased expression in Adrenal (RPKM 1293.6), Liver (RPKM 156.3) and 9 other tissues.

Summary

Enables ATP citrate synthase activity. Involved in acetyl-CoA metabolic process; citrate metabolic process; and fatty acid biosynthetic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human ACLY (ATP Citrate Lyase). [provided by Alliance of Genome Resources, Apr 2022]

Acly Products(2)

mRNA Protein Name
NM_016987.2 NP_058683.2 ATP-citrate synthase isoform 1
NM_001111095.1 NP_001104565.1 ATP-citrate synthase isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ATP citrate synthase activity IDA
IDA: Inferred from direct assay
2295639 RGD
Biological Process GO Annotation Evidence Reference Source
involved in acetyl-CoA metabolic process IDA
IDA: Inferred from direct assay
18062843 RGD
involved in citrate metabolic process IDA
IDA: Inferred from direct assay
18062843 RGD
involved in fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
11735100 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acly Protein Structure

PLN02235

PLN02235: cl42902 (0 - 418)

PLN02522

PLN02522: cl31895 (488 - 1093)

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  • 1101 a.a.
Protein Preferred Names Protein Names

ATP-citrate synthase

ATP-citrate (pro-S-)-lyase

citrate cleavage enzyme

Orthologs Information

Species Symbol Source ID
Homo sapiens Acly NCBI NCBI:47