1. Gene
  2. ACLY - ATP citrate lyase Gene

ACLY - ATP citrate lyase Gene

Homo sapiens

Also known as ACL; ATPCL; CLATP

Gene ID: 47 | Gene type: protein coding

About ACLY

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,866,917-41,930,545 (from NCBI)

This gene has 10 transcripts (splice variants) and 282 orthologues. Ubiquitous expression in prostate (RPKM 37.3), kidney (RPKM 29.2) and 25 other tissues.

Summary

ATP Citrate Lyase is the primary Enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The Enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

ACLY Products(5)

mRNA Protein Name
NM_198830.2 NP_942127.1 ATP-citrate synthase isoform 2
NM_001303275.1 NP_001290204.1 ATP-citrate synthase isoform 4
XM_005257395.2 XP_005257452.1 ATP-citrate synthase isoform X1
NM_001303274.1 NP_001290203.1 ATP-citrate synthase isoform 3
NM_001096.3 NP_001087.2 ATP-citrate synthase isoform 1

ACLY Protein Structure

ATP-grasp_2

ATP-grasp_2: ATP-grasp domain (52 - 207)

CoA_binding

CoA_binding: CoA binding domain (495 - 600)

Ligase_CoA

Ligase_CoA: CoA-ligase (660 - 784)

Citrate_synt

Citrate_synt: Citrate synthase, C-terminal domain (888 - 1085)

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  • 1101 a.a.
Protein Preferred Names Protein Names

ATP-citrate synthase

ATP-citrate (pro-S-)-lyase

citrate cleavage enzyme

Recombinant ACLY Proteins

Cat. No. Product Name Accession Purity
HY-P72070 ACLY Protein, Human (His-SUMO) P53396 (K4-K265) ≥95%

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Waldenstroem'S Macroglobulinemia

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Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus ACLY VGNC VGNC:59513
Canis familiaris ACLY VGNC VGNC:37511
Macaca mulatta ACLY VGNC VGNC:99112
Rattus norvegicus ACLY RGD RGD:2018
Bos taurus ACLY VGNC VGNC:25543
Mus musculus ACLY MGD MGI:103251
Others ACLY NCBI