Search Result
Results for "
13C-labeled
" in MedChemExpress (MCE) Product Catalog:
1618
Inhibitors & Agonists
1
Biochemical Assay Reagents
1614
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
- HY-170207S
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- HY-W015466S1
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- HY-Y0289S
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- HY-W778152
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- HY-W1110947
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- HY-N0437S2
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- HY-B0401S1
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- HY-W653931
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- HY-W751098
-
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Isotope-Labeled Compounds
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Others
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Aldosterone- 13C3 is a 13C-labeled Aldosterone (HY-113313). Aldosterone is a primary mineralocorticoid and steroid hormone.
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- HY-167810A
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- HY-W771021
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- HY-N0437S1
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- HY-W770285
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- HY-N0437S3
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- HY-W010596S
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METHANEDICARBOXYLIC ACID DIAMIDE-13C3
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Isotope-Labeled Compounds
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Others
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Malonamide- 13C3 (METHANEDICARBOXYLIC ACID DIAMIDE- 13C3) is the 13C-labeled Malonamide (HY-W010596).
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- HY-W778065
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- HY-143857S
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- HY-Y0989S2
-
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1-Phenylethan-1-One-1,2-13C2
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Isotope-Labeled Compounds
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Others
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Acetophenone-1,2- 13C2 is the 13C-labeled Acetophenone. Acetophenone is an organic compound with simple structure .
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- HY-W768283
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GUANINE RIBOSIDE HYDRATE-13C5
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Isotope-Labeled Compounds
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Others
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Guanosine Hydrate- 13C5 (GUANINE RIBOSIDE HYDRATE- 13C5) is the 13C-labeled Guanosine Hydrate (HY-N0090).
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- HY-W750442
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- HY-157077S
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- HY-N0680S3
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- HY-N0521AS
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Isotope-Labeled Compounds
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Cancer
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(+)-Gallocatechin- 13C3 is the 13C-labeled (+)-Gallocatechin. (+)-Gallocatechin is a polyphenol compound from green tea, possesses anticancer activity .
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- HY-N6612S
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-
- HY-147551S
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- HY-W015883S
-
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Endogenous Metabolite
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Metabolic Disease
Cancer
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Fumaric acid- 13C4 is the 13C-labeled Fumaric acid. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.
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- HY-B0337S2
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- HY-W751746
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- HY-W766769
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- HY-W751475
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- HY-76847S2
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- HY-Y0842S
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- HY-144427S
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- HY-W766913
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- HY-W769362
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- HY-W768990
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- HY-100354S
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- HY-W012530S
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- HY-18102BS
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- HY-W776938
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Nicotinic acid ethylester hydrochloride-13C6
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Isotope-Labeled Compounds
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Others
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Ethyl nicotinate hydrochloride- 13C6 (Nicotinic acid ethylester hydrochloride- 13C6) is the 13C-labeled Ethyl nicotinate (HY-W013628).
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- HY-B0456S2
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- HY-W779236
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Propiolic acid ethyl ester-13C3
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Isotope-Labeled Compounds
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Others
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Ethyl Propargylate- 13C3 (Propiolic acid ethyl ester- 13C3) is the 13C-labeled Ethyl propiolate (HY-Y0871).
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- HY-W778202
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Glyoxylic Acid monohydrate-13C2
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Isotope-Labeled Compounds
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Others
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2-Oxoacetic acid hydrate- 13C2 (Glyoxylic Acid monohydrate- 13C2) is the 13C-labeled 2-Oxoacetic acid hydrate (HY-W047499).
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- HY-N0666S4
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- HY-W749645
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- HY-W771072
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- HY-W778173
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- HY-W778774
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![Benz[a]anthracene-7-methanol-13C](//file.medchemexpress.eu/product_pic/hy-w778774.gif)
- HY-Y1088S
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3-Phenylpropionic acid-2,3-13C2; 3-Phenylpropanoic acid-2,3-13C2; 3-Phenyl-n-propionic acid-2,3-13C2
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Endogenous Metabolite
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Others
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Hydrocinnamic acid-2,3- 13C2 is the 13C-labeled Hydrocinnamic acid. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities.
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- HY-W748626
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- HY-10002S
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- HY-W778300
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Sodium cyanoacetate-13C2; 2-Cyano-acetic Acid sodium-13C2
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Isotope-Labeled Compounds
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Others
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Sodium 2-cyanoacetate- 13C2 (Sodium cyanoacetate- 13C2) is the 13C-labeled Sodium 2-cyanoacetate (HY-W129503).
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- HY-50896S1
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CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6
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Isotope-Labeled Compounds
EGFR
Autophagy
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Cancer
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Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR .
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- HY-N0771S
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- HY-144085S
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- HY-W749199
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- HY-W010098S1
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- HY-B2219S2
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- HY-Y0252S3
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Endogenous Metabolite
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Others
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L-Proline- 13C is the 13C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
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- HY-12857S
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- HY-W747961
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Isotope-Labeled Compounds
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Others
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2-(4-(Methylsulfonamido)phenoxy)acetic Acid- 13C is the 13C-labeled 2-(4-(Methylsulfonamido)phenoxy)acetic acid (HY-W714806).
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- HY-N0326S3
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Endogenous Metabolite
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Others
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L-Methionine- 13C is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-79131S
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- HY-W013780S
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- HY-B0504S1
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- HY-B0412S3
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- HY-N0351S
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Endogenous Metabolite
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Cancer
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p-Coumaric acid- 13C3 is the 13C-labeled p-Coumaric acid. p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities.
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- HY-W768287
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- HY-N0623S1
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Tryptophan-13C; Tryptophane-13C
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Endogenous Metabolite
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Metabolic Disease
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L-Tryptophan- 13C is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .
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- HY-W014423S
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H-His-OH-13C hydrochloride hydrate
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Endogenous Metabolite
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Metabolic Disease
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L-Histidine- 13C (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
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- HY-N0898S
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- HY-108226S1
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- HY-N0771S4
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Endogenous Metabolite
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Others
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L-Isoleucine-1- 13C is the 13C-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid . L-Isoleucine is an essential amino acid.
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- HY-W765992
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- HY-W778270
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Isotope-Labeled Compounds
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Others
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2-Oxo clopidogrel- 13C,d3 hydrochloride is the deuterium and 13C-labeled (±)-2-Oxo clopidogrel hydrochloride (HY-W585947).
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- HY-W779017
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- HY-Y0978S3
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- HY-111095S3A
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(R)-2-Hydroxypropionic acid-13C-2 sodium; D-Lactic acid-13C-2 sodium
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Isotope-Labeled Compounds
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Others
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D-(-)-Lactic acid- 13C-2 (sodium) is a 13C-labeled D-(-)-Lactic acid (HY-111095). D-(-)-Lactic acid can be used for a variety of biochemical studies.
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- HY-76204S
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- HY-W768527
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Isotope-Labeled Compounds
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Others
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Methyl piperidine-4-carboxylate hydrochloride- 13C3 is the 13C-labeled Methyl piperidine-4-carboxylate hydrochloride (HY-W002947).
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- HY-W778772
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![Benz[a]anthracene-7-acetonitrile-13C2](//file.medchemexpress.eu/product_pic/hy-w778772.gif)
- HY-Y0252S
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Endogenous Metabolite
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Others
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L-Proline- 13C5 is the 13C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
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- HY-N0486S2
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- HY-N1981S
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- HY-N0717S6
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(S)-Valine-13C5
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Endogenous Metabolite
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Others
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L-Valine- 13C5 is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
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- HY-B0434S
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- HY-W013068S2
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- HY-N0623S2
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- HY-N0486S1
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- HY-W769556
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- HY-W009204S5
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- HY-W750001
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- HY-W014423S2
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H-His-OH-13C6 hydrochloride hydrate
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Endogenous Metabolite
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Metabolic Disease
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L-Histidine- 13C6 (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
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- HY-N0473S4
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- HY-I1111S3
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- HY-N0326S5
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Endogenous Metabolite
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Others
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L-Methionine- 13C5 is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-N0324S2
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Endogenous Metabolite
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Metabolic Disease
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Cholic acid- 13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
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- HY-W145482S1
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- HY-W748574
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- HY-N0473S3
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- HY-15651S
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- HY-113252S1
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- HY-W768246
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- HY-N0091S2
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Purin-6-ol-13C5; Sarcine-13C5
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Endogenous Metabolite
Isotope-Labeled Compounds
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Others
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Hypoxanthine- 13C5 is a 13C-labeled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
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- HY-W768275
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- HY-N0473S2
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- HY-W750987
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- HY-N0326S4
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Endogenous Metabolite
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Others
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L-Methionine-1- 13C is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-N0717S5
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- HY-W777418
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- HY-N7092S22
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D(-)-Fructose-13C3
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Isotope-Labeled Compounds
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Others
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D-Fructose- 13C3 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
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- HY-W654109
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Anthracene, 2-chloro-13C6
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Isotope-Labeled Compounds
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Others
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2-Chloroanthracene- 13C6 (Anthracene, 2-chloro- 13C6) is the 13C-labeled 2-Chloroanthracene (HY-W014272).
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- HY-N1394S
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- HY-W765364
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- HY-128417S4
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- HY-B0388S
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- HY-N0717S4
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(S)-Valine-1-13C
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Endogenous Metabolite
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Others
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L-Valine-1- 13C is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
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- HY-W777823
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- HY-76204S1
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Isotope-Labeled Compounds
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Others
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Glycine ethyl ester- 13C2 hydrochloride is a 13C-labeled Glycine ethyl ester hydrochloride (HY-76204). Glycine ethyl ester monohydrochloride is a Glycine (HY-Y0966) derivative .
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- HY-W750553
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Cyanoacetic Acid Octyl Ester-13C3
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Isotope-Labeled Compounds
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Others
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2-Ethylhexyl 2-cyanoacetate- 13C3 (Cyanoacetic Acid Octyl Ester- 13C3) is the 13C-labeled 2-Ethylhexyl 2-cyanoacetate.
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- HY-W751110
-
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N-Nitro-S-methylisothiourea-13C
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Isotope-Labeled Compounds
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Others
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N'-Nitro(methylsulfanyl)methanimidamide- 13C (N-Nitro-S-methylisothiourea- 13C) is the 13C-labeled N'-Nitro(methylsulfanyl)methanimidamide (HY-W673314).
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- HY-W771036
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- HY-W748002
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-
- HY-N0623S3
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-
- HY-W750263
-
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Acetylformic acid-13C2
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
|
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Pyruvic acid- 13C2 (Acetylformic acid- 13C2) is the 13C-labeled Pyruvic acid (HY-Y0781). Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
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- HY-N7092S24
-
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D(-)-Fructose-13C4
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Isotope-Labeled Compounds
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Others
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D-Fructose- 13C4 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
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- HY-W771037
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- HY-I1111S1
-
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- HY-40354S
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Tasocitinib-13C3; CP-690550-13C3
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JAK
Apoptosis
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Inflammation/Immunology
Cancer
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Tofacitinib- 13C3 is the 13C-labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
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- HY-W777751
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-
- HY-W767285
-
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- HY-W747290
-
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Isotope-Labeled Compounds
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Others
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Bis(methylsulfinylethyl)sulfone- 13C4 is the 13C-labeled 1-(Methylsulfinyl)-2-((2-(methylsulfinyl)ethyl)sulfonyl)ethane (HY-W713530).
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- HY-W770176
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-
- HY-N0473S5
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-
- HY-B0945S
-
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3,5-Dinitrobenzamide-13C6
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Isotope-Labeled Compounds
|
Infection
|
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Nitromide- 13C6 (3,5-Dinitrobenzamide- 13C6) is the 13C-labeled Nitromide (HY-B0945). Nitromide is an anti-parasitic agent .
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- HY-N0666S6
-
-
- HY-W768211
-
-
- HY-B0318S
-
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Bacterial
Parasite
Apoptosis
Antibiotic
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Infection
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Metronidazole- 13C2, 15N2 is the 13C-labeled and 15N-labeled Metronidazole. Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.
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- HY-N0473S7
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-
- HY-N0684S3
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- HY-Y0978S2
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- HY-N0486S5
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-
- HY-113357S
-
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Endogenous Metabolite
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Inflammation/Immunology
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m-Coumaric acid- 13C3 is the 13C-labeled m-Coumaric acid. m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.
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- HY-W778771
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-
![Benz[a]anthracene-7-acetic Acid-13C2](//file.medchemexpress.eu/product_pic/hy-w778771.gif)
- HY-W777862
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-
- HY-W753344
-
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Isotope-Labeled Compounds
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Others
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2-(2,6-Dichlorophenoxy)-N-phenylacetamide- 13C6 is the 13C-labeled 2-(2,6-Dichlorophenoxy)-N-phenylacetamide (HY-W713396).
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- HY-W770721
-
-
- HY-Y0479S
-
-
- HY-W777037
-
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Isotope-Labeled Compounds
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Others
|
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2,3-Dichlorobenzamidyl Guanidine- 13C2 is the 13C-labeled 2-(2,3-Dichlorobenzoyl)hydrazine-1-carboximidamide (HY-W727201).
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- HY-N0382S
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-
- HY-13693S2
-
-
- HY-W766920
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-
- HY-B0178AS
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Guanidinium-13C,15N3 chloride; Aminoformamidine-13C,15N3 hydrochloride
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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Guanidine- 13C, 15N3 (hydrochloride)is the 13C-labeled and 15N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins .
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- HY-15097S
-
-
- HY-B2156S1
-
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Vitamin K2(MK-4)-13C6; Menaquinone K4-13C6
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Isotope-Labeled Compounds
Endogenous Metabolite
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Cancer
|
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Menaquinone-4- 13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
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- HY-N6618S
-
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Isotope-Labeled Compounds
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Others
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DL-Mannitol- 13C is the 13C-labeled DL-Mannitol. DL-Mannitol is obtained by combining D-mannitol with a sample of Lmannitol obtained by reduction of L-mannono-1, Clactone .
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- HY-113283S
-
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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Homogentisic acid- 13C6 is the 13C-labeled Homogentisic acid (HY-113283). Homogentisic acid is a specific metabolite that accumulates in the urine and serum. Homogentisic acid can be used for diagnosis of alkaptonuria. Homogentisic acid is a phenolic acid .
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- HY-16637S3
-
-
- HY-W749742
-
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Triphenyl(propan-2-yl)phosphonium bromide-13C3
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Isotope-Labeled Compounds
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Others
|
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Isopropyltriphenylphosphonium bromide- 13C3 (Triphenyl(propan-2-yl)phosphonium bromide- 13C3) is the 13C-labeled Isopropyltriphenylphosphonium bromide (HY-W013757).
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-
- HY-W778203
-
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Hydroxyethanoic acid-13C2
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Isotope-Labeled Compounds
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Others
|
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Glycolic acid- 13C2 is the 13C-labeled Glycolic acid (HY-W015967). Glycolic acid- 13C2 is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
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-
- HY-N0593S3
-
-
- HY-N7092S23
-
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D(-)-Fructose-13C3-1
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Isotope-Labeled Compounds
|
Others
|
|
D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-N0455AS7
-
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(S)-(+)-Arginine-13C hydrochloride
|
NO Synthase
Endogenous Metabolite
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Others
|
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L-Arginine- 13C (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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- HY-N0473S6
-
-
- HY-W771025
-
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Tetramethylene Iodide (stabilized with Copper chip)-13C4
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Isotope-Labeled Compounds
|
Others
|
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1,4-Diiodobutane- 13C4 (Tetramethylene Iodide (stabilized with Copper chip)- 13C4) is the 13C-labeled 1,4-Diiodobutane (HY-W004871).
|
-
- HY-B0456S
-
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Vitamin B2-13C4,15N2; E101-13C4,15N2
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Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
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Riboflavin- 13C4, 15N2is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-W778791
-
-
- HY-144343S
-
-
- HY-W778297
-
-
- HY-W392933S3
-
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Thymidine-5'-phosphate-13C10 dilithium
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Isotope-Labeled Compounds
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Others
|
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Thymidine 5'-monophosphate- 13C10 (Thymidine-5'-phosphate- 13C10) dilithium is 13C-labeled Thymidine 5'-monophosphate (HY-W392933).
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-
- HY-W024986S
-
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4'-Hexyloxy-4-biphenylcarbonitrile-13C6
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Isotope-Labeled Compounds
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Others
|
|
4-(4-Hexoxyphenyl)benzonitrile- 13C6 (4'-Hexyloxy-4-biphenylcarbonitrile- 13C6) is the 13C-labeled 4-(4-Hexoxyphenyl)benzonitrile.
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- HY-N0391S3
-
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Endogenous Metabolite
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Others
|
|
L-Citrulline- 13C is the 13C-labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
|
-
- HY-W000450S
-
-
- HY-N0650S1
-
|
(-)-Serine-13C; (S)-Serine-13C
|
Endogenous Metabolite
|
Cancer
|
|
L-Serine- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-W770294
-
|
Tetrabromophthalic acid-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
3,4,5,6-Tetrabromophthalic acid- 13C6 (Tetrabromophthalic acid- 13C6) is the 13C-labeled 3,4,5,6-Tetrabromophthalic acid (HY-W259069).
|
-
- HY-B0892S
-
-
- HY-W778790
-
-
- HY-N0666S1
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
L-Aspartic acid- 13C4, 15N is the 13C-labeled and 15N-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
|
-
- HY-W751444
-
|
4-Methoxy-m-xylene-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
2,4-Dimethylanisole- 13C6 (4-Methoxy-m-xylene- 13C6) is the 13C-labeled 2,4-Dimethylanisole (HY-W100677).
|
-
- HY-W753343
-
|
2-Chloroacetanilide-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
2-Chloro-N-phenylacetamide- 13C6 (2-Chloroacetanilide- 13C6) is the 13C-labeled 2-Chloro-N-phenylacetamide (HY-W069522).
|
-
- HY-W018386S1
-
-
- HY-I0960S
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Uracil- 13C2, 15N2 is the 13C-labeled and 15N-labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
|
-
- HY-134178S1
-
-
- HY-W015084S
-
|
|
Isotope-Labeled Compounds
Apoptosis
|
Cancer
|
|
β-Ionone- 13C3 is the 13C-labeled β-Ionone. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .
|
-
- HY-W778171
-
-
- HY-113400S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Cytidine diphosphate- 13C9 dilithium is 13C-labeled Cytidine diphosphate (HY-113400). Cytidine diphosphate is a nucleoside diphosphate that acts as a carrier for phosphorylcholine, diacylglycerol, and other molecules during phospholipid synthesis.
|
-
- HY-W770952
-
|
N-Acetyl-S-phenyl-L-cysteine-13C6
|
Isotope-Labeled Compounds
Amino Acid Derivatives
|
Others
|
|
DL-Phenylmercapturic Acid- 13C6 (N-Acetyl-S-phenyl-L-cysteine- 13C6) is the 13C-labeled DL-Phenylmercapturic Acid (HY-W141770). DL-Phenylmercapturic Acid is a cysteine derivative .
|
-
- HY-10285S1
-
-
- HY-115584S
-
|
|
Isotope-Labeled Compounds
Parasite
|
Infection
|
|
Lufenuron- 13C6 is a 13C-labeled Lufenuron. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods .
|
-
- HY-W777496
-
-
- HY-N0455AS6
-
|
(S)-(+)-Arginine-13C6 hydrochloride
|
Isotope-Labeled Compounds
NO Synthase
Endogenous Metabolite
|
Others
|
|
L-Arginine- 13C6 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-16271S
-
|
|
Isotope-Labeled Compounds
MDM-2/p53
|
Cancer
|
|
Kevetrin (hydrochloride)- 13C2, 15N3 is the 13C-labeled and 15N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
|
-
- HY-W754199
-
|
Guanidinoacetic acid-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Glycocyamine- 13C (Guanidinoacetic acid- 13C) is the 13C-labeled Glycocyamine (HY-W021448). Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird.
|
-
- HY-N0384S3
-
|
Vanilacetic acid-13C6,18O
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Homovanillic acid- 13C6, 18O is the 13C-labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
|
-
- HY-W778172
-
-
- HY-18260S2
-
-
- HY-N0650S
-
|
(-)-Serine-13C3; (S)-Serine-13C3
|
Endogenous Metabolite
|
Cancer
|
|
L-Serine- 13C3 is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-113251S1
-
-
- HY-W017018S1
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Ornithine-1,2- 13C2 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
- HY-N0229S9
-
|
L-2-Aminopropionic acid-13C2
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
L-Alanine- 13C2 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-W778716
-
|
Propanedinitrile, 2-(1-ethoxyethylidene)-13C2; a-Cyano-b-methyl-b-ethoxyacrylonitrile-13C2
|
Isotope-Labeled Compounds
|
Others
|
|
2-(1-Ethoxyethylidene)malononitrile- 13C2 (Propanedinitrile, 2-(1-ethoxyethylidene)- 13C2) is the 13C-labeled 2-(1-Ethoxyethylidene)malononitrile (HY-W008403).
|
-
- HY-W749665
-
|
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Cancer
|
|
Clindamycin Hydrochloride- 13C,d3 is the deuterium and 13C-labeled Clindamycin hydrochloride (HY-B0408A). Clindamycin hydrochloride is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal.
|
-
- HY-W751099
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Corticosterone- 13C3 is a 13C-labeled corticosterone (HY-B1618). Corticosterone (17-Deoxycortisol) is an orally available glucocorticoid that can regulate limbic system neurons and has good immunosuppressive activity.
|
-
- HY-N0650S2
-
|
(-)-Serine-1-13C; (S)-Serine-1-13C
|
Endogenous Metabolite
|
Cancer
|
|
L-Serine-1- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-W753497
-
|
Trimellitic Acid-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
Benzene-1,2,4-tricarboxylic acid- 13C3 (Trimellitic Acid- 13C3) is the 13C-labeled Benzene-1,2,4-tricarboxylic acid (HY-W014409).
|
-
- HY-N0229S8
-
|
L-2-Aminopropionic acid-13C3
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
L-Alanine- 13C3 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0216S2
-
|
|
Bacterial
Fungal
Endogenous Metabolite
|
Infection
|
|
Benzoic acid- 13C is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
|
-
- HY-144920S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Tacrolimus impurity 16- 13C,d2 is the deuterium labeled and 13C-labeled 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506 (HY-W777541).
|
-
- HY-W654157
-
|
|
Bacterial
Antibiotic
Isotope-Labeled Compounds
|
Infection
|
|
Dicloxacillin- 13C4 sodium hydrate is the 13C-labeled Dicloxacillin Sodium hydrate (HY-B0977). Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-B2130S2
-
-
- HY-W768574
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Bisphenol A Bissulfate Disodium Salt- 13C12 is the 13C-labeled Sodium S,S′-[(1-methylethylidene)di-4,1-phenylene] disulfate (2:1) (HY-W587516).
|
-
- HY-W012835S2
-
|
4-Methoxytoluene-13C
|
Isotope-Labeled Compounds
|
Others
|
|
4-Methylanisole- 13C is the 13C-labeled 4-Methylanisole. 4-Methylanisole (4-Methoxytoluene) is food flavoring agent and can be naturally found in Ylang Ylang fragrance oil .
|
-
- HY-N0455AS3
-
|
(S)-(+)-Arginine-1-13C hydrochloride
|
NO Synthase
Endogenous Metabolite
|
Others
|
|
L-Arginine-1- 13C (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-W749598
-
|
3-Pyridinecarboxamide, N-methoxy-N-methyl-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
N-Methoxy-N-methylnicotinamide- 13C6 (3-Pyridinecarboxamide, N-methoxy-N-methyl- 13C6) is the 13C-labeled N-methoxy-N-methylnicotinamide (HY-W051270).
|
-
- HY-N0356S
-
|
|
Isotope-Labeled Compounds
COX
|
Cancer
|
|
(+/-)-Catechin Gallate- 13C3 is the 13C-labeled (-)-Catechin gallate. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
|
-
- HY-B1337S4
-
|
|
Cholinesterase (ChE)
|
Others
|
|
Choline Chloride- 13C3 is the 13C-labeled Choline (chloride). Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.
|
-
- HY-N0650S4
-
|
(-)-Serine-2-13C; (S)-Serine-2-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
L-Serine-2- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-Y0966S3
-
-
- HY-W042357S4
-
-
- HY-W752253
-
-
- HY-W777534
-
|
N-Acetylsulfanilyl chloride-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
4-Acetamidobenzene-1-sulfonyl chloride- 13C6 (N-Acetylsulfanilyl chloride- 13C6) is the 13C-labeled 4-Acetamidobenzene-1-sulfonyl chloride (HY-W012207).
|
-
- HY-W016498S1
-
-
- HY-N0216S1
-
|
|
Bacterial
Fungal
Endogenous Metabolite
|
Infection
|
|
Benzoic acid- 13C6 is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
|
-
- HY-N0229S7
-
-
- HY-Y1250S3
-
|
Fmoc-glycine-13C
|
Isotope-Labeled Compounds
|
Others
|
|
Fmoc-Gly-OH- 13C is a 13C-labeled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .
|
-
- HY-Y0966S2
-
|
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine-2- 13C is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-N0470S2
-
-
- HY-W780162
-
|
Succinic Acid Monomethyl Ester-13C4; Butanedioic Acid 1-Methyl Ester-13C4
|
Isotope-Labeled Compounds
|
Others
|
|
4-Methoxy-4-oxobutanoic acid- 13C4 (Succinic Acid Monomethyl Ester- 13C4) is the 13C-labeled 4-Methoxy-4-oxobutanoic acid (HY-W010380).
|
-
- HY-N0229S6
-
-
- HY-W338810S
-
-
- HY-N0187S
-
|
Hymecromone-13C4; 4-MU-13C4
|
Isotope-Labeled Compounds
|
Cancer
|
|
4-Methylumbelliferone- 13C4 (Hymecromone- 13C4) is the 13C-labeled 4-Methylumbelliferone (HY-N0187). 4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects.
|
-
- HY-W393970S2
-
|
5'-Deoxyguanylic acid-13C10 dilithium
|
Isotope-Labeled Compounds
|
Others
|
|
2′-Deoxyguanosine 5′-monophosphate- 13C10 (5'-Deoxyguanylic acid- 13C10) dilithium is 13C-labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-N0229S1
-
|
L-2-Aminopropionic acid-1-13C
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
L-Alanine-1- 13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-W143131S
-
|
Itaconic Acid Diethyl Ester (stabilized with TBC)-13C5
|
Isotope-Labeled Compounds
|
Others
|
|
Diethyl itaconate,98% (stabilized with TBC)- 13C5 (Itaconic Acid Diethyl Ester (stabilized with TBC)- 13C5) is the 13C-labeled Diethyl itaconate,98% (stabilized with TBC) (HY-W143131).
|
-
- HY-Y0966S4
-
|
|
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
Glycine-1- 13C is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-W754303
-
|
Dihydroqinghaosu-13C,d5; β-Dihydroartemisinin-13C,d5; Artenimol-13C,d5
|
Isotope-Labeled Compounds
Apoptosis
Autophagy
Parasite
NF-κB
|
Cancer
|
|
Dihydroartemisinin- 13C,d5 (Dihydroqinghaosu- 13C,d5) is the deuterium labeled and 13C-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is a potent anti-malaria agent.
|
-
- HY-17563S2
-
|
Deoxyguanosine-13C10; Guanine deoxyriboside-13C10
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
2'-Deoxyguanosine- 13C10 (Deoxyguanosine- 13C10; Guanine deoxyriboside- 13C10) is 13C-labeled 2'-Deoxyguanosine (HY-17563). 2'-Deoxyguanosine (Deoxyguanosine) is deoxyguanosine.
|
-
- HY-W776973
-
|
Oxiranecarboxamide-13C3; 2,3-Epoxypropanamide-13C3
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Glycidamide- 13C3 (Oxiranecarboxamide- 13C3) is the 13C-labeled Glycidamide (HY-119329). Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects .
|
-
- HY-W777439
-
-
- HY-W766785
-
|
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Tiamulin Fumarate- 13C4 is the 13C-labeled Tiamulin. Tiamulin (Thiamutilin) fumarate is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin fumarate is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
|
-
- HY-N0683S
-
-
- HY-W134007S1
-
-
- HY-N0469S1
-
|
|
Endogenous Metabolite
Virus Protease
|
Inflammation/Immunology
|
|
L-Lysine- 13C6 (dihydrochloride) is the 13C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions .
|
-
- HY-W756750
-
-
- HY-W040047S
-
-
- HY-W017018S2
-
-
- HY-128417S5
-
-
- HY-113225S2
-
-
- HY-B0289S
-
-
- HY-W747332
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Pyruvic aldehyde (42% in water)- 13C3 is the 13C-labeled Pyruvic aldehyde (42% in water) (HY-W020014). Pyruvic aldehyde (42% in water) is often used as a reagent in organic synthesis, as a flavoring agent, and in tanning.
|
-
- HY-N0455AS5
-
|
(S)-(+)-Arginine-1,2-13C2 hydrochloride
|
Isotope-Labeled Compounds
NO Synthase
Endogenous Metabolite
|
Others
|
|
L-Arginine-1,2- 13C2 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-79096S
-
-
- HY-N1132AS2
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Alpha,Beta-Trehalose- 13C12 is the 13C-labeled D-(+)-Trehalose dihydrate (HY-N1132A). D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.
|
-
- HY-W777836
-
-
- HY-114293S
-
-
- HY-N0683S1
-
-
- HY-W777351
-
-
- HY-W739894S
-
-
- HY-W018241S
-
|
2,2-Sulfonyldiethanol-13C4
|
Isotope-Labeled Compounds
|
Others
|
|
2,2'-Sulfonyldiethanol(65% in water)- 13C4 (2,2-Sulfonyldiethanol- 13C4) is the 13C-labeled 2,2'-Sulfonyldiethanol(65% in water) (HY-W018241).
|
-
- HY-W010382S
-
|
2-Oxosuccinic acid-13C4
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Oxaloacetic acid- 13C4 is the 13C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis .
|
-
- HY-112675S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
4-Octyl itaconate- 13C5-1 is 13C-labeled 4-Octyl itaconate (HY-112675). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
|
-
- HY-Y0479S3
-
-
- HY-Y1250S5
-
-
- HY-W777833
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Ethyl 2-(6-nitro-2,3-dichlorobenzyl)glycine- 13C2 is the 13C-labeled Ethyl (2,3-dichloro-6-nitrobenzyl)glycinate (HY-W701652).
|
-
- HY-B0167S1
-
-
- HY-Y1250S4
-
|
Fmoc-glycine-1-13C
|
Fungal
|
Infection
Cancer
|
|
Fmoc-Gly-OH-1- 13C is a 13C-labeled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .
|
-
- HY-B0315S
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Vitamin B12- 13C7 is the 13C-labeled Vitamin B12. Vitamin B12 is a vitamin. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood .
|
-
- HY-15407AS
-
|
AHU-377-13C4 hemicalcium salt
|
Isotope-Labeled Compounds
Neprilysin
|
Cardiovascular Disease
|
|
Sacubitril- 13C4 (hemicalcium salt) is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696 .
|
-
- HY-W766332
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
7-Hydroxy coumarin glucuronide sodium- 13C6 is the 13C-labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
|
-
- HY-N0060S1
-
-
- HY-16637S2
-
|
(Rac)-Vitamin B9-13C5,15N; (Rac)-Vitamin M-13C5,15N
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
|
(Rac)-Folic acid- 13C5, 15N is the 13C-labeled and 15N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
|
-
- HY-B0122SS1
-
-
- HY-W042357S5
-
|
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
|
Ac-rC Phosphoramidite- 13C,d1 is deuterium and 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
- HY-N1393S
-
|
NSC 3778-13C6; O-Methylsalicylic acid-13C6; Salicylic acid methyl ether-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
2-Methoxybenzoic acid- 13C6 is the 13C-labeled 2-Methoxybenzoic acid. 2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.
|
-
- HY-W768912
-
-
- HY-W770183
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Uric acid- 13C3 is 13C-labeled Uric acid (HY-B2130). Uric acid is the end product of purine metabolism in the human body. Uric acid can scavenge reactive oxygen species (ROS), such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation.
|
-
- HY-W020044S
-
|
|
Isotope-Labeled Compounds
Ferroptosis
|
Others
|
|
DL-alpha-Tocopherol- 13C3 is the 13C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .
|
-
- HY-B0456S1
-
|
Vitamin B2-13C4,15N2-1; E101-13C4,15N2-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-W017401S
-
|
BIT-13C6
|
Isotope-Labeled Compounds
Bacterial
|
Others
|
|
Benzisothiazolinone-13C5 (1,2-Benzothiazol-3-one-13C5) is a 13C-labeled Benzisothiazolinone. Benzisothiazolinone is widely used as an antiseptic and antibacterial agent .
|
-
- HY-W768295
-
-
- HY-W747213
-
|
MALIC ACID, 3-METHYL-, DIETHYL ESTER-13C
|
Isotope-Labeled Compounds
|
Others
|
|
Diethyl 2-hydroxy-3-methylsuccinate- 13C (MALIC ACID, 3-METHYL-, DIETHYL ESTER- 13C) is the 13C-labeled Diethyl 2-hydroxy-3-methylsuccinate (HY-W502469).
|
-
- HY-W779800
-
-
- HY-100760S
-
-
- HY-W769319
-
|
5'-IMP-13C5; IMP-13C5; Inosine 5'-(dihydrogen phosphate)-13C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Inosinic acid- 13C5 (5'-IMP- 13C5) is the 13C-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .
|
-
- HY-B0859S
-
|
4-Chloro-2-Methylphenoxyacetic acid-13C8
|
Isotope-Labeled Compounds
|
Others
|
|
MCPA- 13C8 is the 13C-labeled MCPA. MCPA is a phenoxy herbicide, and widely used to control annual and perennial broad leaved weeds, including poppy, thistles and docks, in crops such as cereals, rice, linseed, flax, grassland and turf .
|
-
- HY-113225S5
-
-
- HY-W749378
-
-
- HY-15398S1
-
-
- HY-W769734
-
-
- HY-W768296
-
-
- HY-W654084
-
-
- HY-W048482S2
-
|
DMT-2'O-TBDMS-rU phosphoramidite-13C9
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
|
rU Phosphoramidite- 13C9 (DMT-2'O-TBDMS-rU phosphoramidite- 13C9) is 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-W777477
-
-
- HY-W753370
-
|
Benzene, 1,2,4-trichloro-5-nitro-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
2,4,5-Trichloronitrobenzene- 13C6 (Benzene, 1,2,4-trichloro-5-nitro- 13C6) is the 13C-labeled 2,4,5-Trichloronitrobenzene (HY-W142633).
|
-
- HY-167906S
-
-
- HY-W777546
-
|
Acetic Acid 5-Formylfurfuryl Ester-13C6; 5-Acetoxymethyl-2-furaldehyde-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
(5-Formylfuran-2-yl)methyl acetate- 13C6 (Acetic Acid 5-Formylfurfuryl Ester- 13C6) is the 13C-labeled (5-Formylfuran-2-yl)methyl acetate (HY-W111899).
|
-
- HY-Y0313S1
-
-
- HY-I0626S
-
|
|
Endogenous Metabolite
|
Others
|
|
Cytosine- 13C2, 15N3 is the 13C-labeled and 15N-labeled Cytosine. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging .
|
-
- HY-W768324
-
|
Adonitol-13C5; Adonite-13C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Ribitol- 13C5 (Adonitol- 13C5) is the 13C-labeled Ribitol (HY-100582). Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol.
|
-
- HY-W778655
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Desmethylene oxobexarotene methyl ester- 13C4 is the 13C-labeled Methyl 4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzoate (HY-W130051).
|
-
- HY-B0202S4
-
-
- HY-14608S
-
|
|
Endogenous Metabolite
iGluR
Ferroptosis
Apoptosis
|
Neurological Disease
|
|
L-Glutamic acid- 13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
|
-
- HY-B0891S1
-
|
17-Hydroxyprogesterone-13C3; 17-OHP-13C3
|
Isotope-Labeled Compounds
Progesterone Receptor
Endogenous Metabolite
|
Others
|
|
17α-Hydroxyprogesterone- 13C3 is the 13C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
|
-
- HY-D0187S4
-
|
GSH-13C; γ-L-Glutamyl-L-cysteinyl-glycine-13C
|
Isotope-Labeled Compounds
|
Others
|
|
L-Glutathione reduced- 13C (GSH- 13C; γ-L-Glutamyl-L-cysteinyl-glycine- 13C) is 13C-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced is an endogenous antioxidant and oxygen free radical scavenger.
|
-
- HY-N6625S
-
|
|
Fungal
|
Inflammation/Immunology
|
|
Chlorothalonil- 13C2 is the 13C-labeled Chlorothalonil. Chlorothalonil is a broad spectrum fungicide and is effective in protecting plants against fungal diseases caused mainly by Phytophthora infestans and Alternaria solani. Chlorothalonil is used for controlling of fungal foliar diseases of vegetables and crops .
|
-
- HY-B2039S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Bentazone- 13C10, 15N is the 13C-labeled and 15N-labeled Bentazone. Bentazone is a post-emergence herbicide used for selective control of broadleaf weeds and sedges in beans, rice, corn, peanuts, mint and others. It acts by interfering with photosynthesis .
|
-
- HY-W777806
-
-
![Pyrimido[1,2-a]purin-10(1H)-one-13C3](//file.medchemexpress.eu/product_pic/hy-w777806.gif)
- HY-18341S1
-
-
- HY-W768181
-
-
- HY-B0141S4
-
-
- HY-124489S
-
-
- HY-W018386S
-
|
3-Bromo-Tyr-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
3-?Bromo-?L-?tyrosine- 13C6 (3-Bromo-Tyr- 13C6) is a 13C-labeled 3-?Bromo-?L-?tyrosine (HY-W018386). 3- Bromo- L- tyrosine (3-Bromo-Tyr) is a tyrosine derivative .
|
-
- HY-W007527S
-
|
4-Bromo-2-Chloro Phenol-13C6; 2-Chloro-4-Bromo Phenol13C6
|
Isotope-Labeled Compounds
|
Others
|
|
4-Bromo-2-chlorophenol- 13C6 (4-Bromo-2-Chloro Phenol- 13C6) is the 13C-labeled 4-Bromo-2-chlorophenol (HY-W007527).
|
-
- HY-B0234S
-
-
- HY-W754548
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
Glycocholic acid- 13C2,d4 is the deuterium labeled and 13C-labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways .
|
-
- HY-Y1055S4
-
-
- HY-W015913S
-
|
Sodium pyruvate-13C3
|
Reactive Oxygen Species (ROS)
Endogenous Metabolite
|
Metabolic Disease
|
|
Sodium 2-oxopropanoate- 13C3 is the 13C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .
|
-
- HY-B1776AS1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Spermidine- 13C4 (hydrochloride) is the 13C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .
|
-
- HY-14608S5
-
|
|
Endogenous Metabolite
iGluR
Ferroptosis
Apoptosis
|
Neurological Disease
|
|
L-Glutamic acid- 13C5 is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
|
-
- HY-10999S1
-
|
|
MEK
Autophagy
Apoptosis
|
Cancer
|
|
Trametinib- 13C6 is the 13C-labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis .
|
-
- HY-N0092S4
-
-
- HY-W768220
-
-
- HY-W042357S3
-
|
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
|
Ac-rC Phosphoramidite- 13C2,d1 is deuterium and 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
- HY-N0229S
-
-
- HY-B0141S5
-
-
- HY-B0234S3
-
-
- HY-W777340
-
-
- HY-W778257
-
|
4,6-dichloropyrimidin-2-ylamine-13C2
|
Isotope-Labeled Compounds
|
Others
|
|
2-Amino-4,6-dichloropyrimidine- 13C2 (4,6-dichloropyrimidin-2-ylamine- 13C2) is the 13C-labeled 2-Amino-4,6-dichloropyrimidine (HY-41261).
|
-
- HY-B0216S2
-
-
- HY-15398S4
-
-
- HY-143687S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
3-Cyano Gimeracil methyl ether- 13C3 is the 13C-labeled 5-Chloro-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile (HY-W050667).
|
-
- HY-B0150S2
-
|
Niacinamide-13C6; Nicotinic acid amide-13C6
|
Endogenous Metabolite
Sirtuin
|
Neurological Disease
Cancer
|
|
Nicotinamide- 13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
|
-
- HY-W778002
-
-
- HY-W768856
-
|
Dihydroqinghaosu methyl ether-13C,d3; Dihydroartemisinin methyl ether-13C,d3; SM224-13C,d3
|
Isotope-Labeled Compounds
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
|
Artemether- 13C,d3 (Dihydroqinghaosu methyl ether- 13C,d3) is the deuterium and 13C-labeled Artemether (HY-N0402). Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .
|
-
- HY-W747264
-
-
- HY-B0574S2
-
|
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Mefenamic acid- 13C6 is the 13C-labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
|
-
- HY-B2236S1
-
|
(±)-2,6-Diaminocaproic acid-13C6 hydrochloride
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is 13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-N0682S3
-
|
Pyridoxol-13C4 hydrochloride; Vitamin B6-13C4 hydrochloride
|
Isotope-Labeled Compounds
Endogenous Metabolite
Keap1-Nrf2
|
Neurological Disease
|
|
Pyridoxine- 13C4 (hydrochloride) is the 13C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
|
-
- HY-10572S1
-
-
- HY-W778162
-
|
|
Isotope-Labeled Compounds
Apoptosis
|
Cancer
|
|
Phenanthrene- 13C2 is the 13C-labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
|
-
- HY-14608S6
-
-
- HY-N0325S
-
|
|
Isotope-Labeled Compounds
Parasite
|
Infection
Inflammation/Immunology
|
|
DL-Methionine- 13C is the 13C-labeled DL-Methionine. DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants .
|
-
- HY-W751537
-
|
4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
4-[[(4-Fluorophenyl)imino]methyl]phenol- 13C6 (4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol- 13C6) is the 13C-labeled 4-[[(4-Fluorophenyl)imino]methyl]phenol (HY-W014178).
|
-
![4-[[(4-Fluorophenyl)imino]methyl]phenol-13C6](//file.medchemexpress.eu/product_pic/hy-w751537.gif)
- HY-W016814S
-
|
cis-Aconitic acid-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
(Z)-Aconitic acid- 13C6 is the 13C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
|
-
- HY-W127578S1
-
|
Oxiran-2-ylmethyl palmitate-13C16
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Glycidyl palmitate- 13C16 (Oxiran-2-ylmethyl palmitate- 13C16) is the 13C-labeled Glycidyl palmitate (HY-W127578). Glycidyl Palmitate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W777002
-
-
- HY-W128417S
-
|
DmPABr-13C2,d6
|
Isotope-Labeled Compounds
|
Others
|
|
4-(Dimethylamino)phenacyl bromide- 13C2,d6 (DmPABr- 13C2,d6) is 13C-labeled 4-(Dimethylamino)phenacyl bromide (HY-W128417) .
|
-
- HY-14608S1
-
|
|
Endogenous Metabolite
iGluR
Ferroptosis
Apoptosis
|
Neurological Disease
|
|
L-Glutamic acid-1- 13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
|
-
- HY-N0067S3
-
-
- HY-W008253S3
-
-
- HY-W778023
-
|
(R)-(-)-Ketoprofen-13C,d3
|
Isotope-Labeled Compounds
|
Others
|
|
(R)-2-(3-Benzoylphenyl)propanoic acid- 13C,d3 ((R)-(-)-Ketoprofen- 13C,d3) is the deuterium labeled and 13C-labeled Ketoprofen-d3-1 (HY-W322573S).
|
-
- HY-N7091S1
-
|
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Atrazine- 13C3, 15N3 is the 13C-labeled and 15N-labeled Atrazine. Atrazine is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term .
|
-
- HY-50723S
-
|
|
Endogenous Metabolite
|
Others
|
|
3-Methylxanthine- 13C4, 15N3 is the 13C-labeled and 15N-labeled 3-Methylxanthine. 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
|
-
- HY-113128S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
sn-Glycerol 3-phosphate- 13C3 disodium is the 13C-labeled sn-Glycerol 3-phosphate disodium. sn-Glycerol 3-phosphate disodium is produced by cytosolic glycerol 3-phosphate dehydrogenase pathway through the reduction of dihydroxyacetone phosphate using NADH formed during glycolysis .
|
-
- HY-W750399
-
|
Tetrabromophthalic anhydride-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
4,5,6,7-Tetrabromoisobenzofuran-1,3-dione- 13C6 (Tetrabromophthalic anhydride- 13C6) is the 13C-labeled 4,5,6,7-Tetrabromoisobenzofuran-1,3-dione (HY-W010833).
|
-
- HY-Y0337S4
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Cysteine- 13C3 is the 13C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .
|
-
- HY-W777440
-
-
- HY-W752476
-
|
N6-Succinyl adenosine-13C4
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Succinyladenosine- 13C4 (N6-Succinyl adenosine- 13C4) is the 13C-labeled Succinyladenosine (HY-113284). Succinyladenosine, the metabolic product of dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase, is a biochemical marker of adenylosuccinase (ASL) deficiency .
|
-
- HY-113359AS1
-
-
- HY-W779404
-
|
Ribasphere-13C2
|
Isotope-Labeled Compounds
RSV
HCV
Antibiotic
Orthopoxvirus
|
Cancer
|
|
Ribavirin- 13C2 (Ribasphere- 13C2) is the 13C-labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
|
-
- HY-W777329
-
|
(E)-Oct-4-ene-1,8-dioic acid-13C2
|
Isotope-Labeled Compounds
|
Others
|
|
(4E)-4-Octenedioic acid- 13C2 ((E)-Oct-4-ene-1,8-dioic acid- 13C2) is the 13C-labeled (4E)-4-Octenedioic acid (HY-W151203).
|
-
- HY-N0390S1
-
-
- HY-B0843S
-
|
|
Isotope-Labeled Compounds
Fungal
|
Infection
|
|
Metalaxyl- 13C6 is the 13C-labeled Metalaxyl. Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s=0.3-3.9 μg/mL).
|
-
- HY-Y0337S2
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Cysteine-3- 13C is the 13C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .
|
-
- HY-W014993S
-
|
|
Endogenous Metabolite
|
Others
|
|
1,3-Dimethyluric acid- 13C4, 15N3 is the 13C-labeled and 15N-labeled 1,3-Dimethyluric acid. 1,3-Dimethyluric acid is a product of theophylline metabolism in man. 1,3-Dimethyluric acid is one of the purine components in urinary calculi.
|
-
- HY-W778236
-
|
SAN 9789-13C,d3
|
Isotope-Labeled Compounds
Herbicide
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Others
|
|
Norflurazon- 13C,d3 (SAN 9789- 13C,d3) is the deuterium and 13C-labeled Norflurazon (HY-114849). Norflurazon (SAN 9789) is a bleaching herbicide. Norflurazon can block carotenoid biosynthesis by inhibiting phytoene desaturase activity .
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-
- HY-W767035
-
-
- HY-Y0337S3
-
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Endogenous Metabolite
|
Metabolic Disease
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|
L-Cysteine-1- 13C is the 13C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .
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-
- HY-41121S1
-
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
|
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Boc-L-Ala-OH-3- 13C is a 13C-labeled Boc-L-Ala-OH (HY-41121). Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .
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-
- HY-41121S2
-
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Isotope-Labeled Compounds
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Others
|
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Boc-L-Ala-OH-2- 13C is a 13C-labeled Boc-L-Ala-OH (HY-41121). Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .
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-
- HY-N0830S10
-
-
- HY-W777266
-
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Isotope-Labeled Compounds
Biochemical Assay Reagents
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Others
|
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Cyclohexane-1,3-dione- 13C3 is the 13C-labeled Cyclohexane-1,3-dione (HY-W007466). Cyclohexane-1,3-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-N0390S4
-
-
- HY-D0184S5
-
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Deoxycytidine-13C9; Cytosine deoxyriboside-13C9; Deoxyribose cytidine-13C9
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Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
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2'-Deoxycytidine- 13C9 (Deoxycytidine- 13C9; Cytosine deoxyriboside- 13C9; Deoxyribose cytidine- 13C9) is 13C-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
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-
- HY-W766699
-
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6-Amino-2-thiouracil Monohydrate-13C
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Isotope-Labeled Compounds
|
Others
|
|
6-Amino-4-hydroxy-2-mercaptopyrimidine- 13C (6-Amino-2-thiouracil Monohydrate- 13C) is the 13C-labeled 6-Amino-4-hydroxy-2-mercaptopyrimidine (HY-75601).
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-
- HY-B0351S1
-
|
2-Aminoethanesulfonic acid-13C2
|
Autophagy
Endogenous Metabolite
|
Metabolic Disease
|
|
Taurine- 13C2 is the 13C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes .
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-
- HY-W654362
-
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Isotope-Labeled Compounds
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Others
|
|
(R)-2-Thioxothiazolidine-4-carboxylic acid- 13C3 is the 13C-labeled (R)-2-Thioxothiazolidine-4-carboxylic acid. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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-
- HY-N0830S6
-
-
- HY-N0830BS1
-
-
- HY-N0390S5
-
-
- HY-13632S1
-
|
|
Isotope-Labeled Compounds
Cytochrome P450
|
Endocrinology
Cancer
|
|
Exemestane- 13C3 is the 13C-labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
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-
- HY-14749AS1
-
|
|
Isotope-Labeled Compounds
Parasite
|
Cancer
|
|
Pyronaridine tetraphosphate- 13C2,d4 is the deuterium and 13C-labeled Pyronaridine tetraphosphate (HY-14749A). Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection .
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-
- HY-176145S
-
-
- HY-111095S1
-
|
(R)-2-Hydroxypropionic acid-13C; D-Lactic acid-13C
|
Isotope-Labeled Compounds
|
Others
|
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D-(-)-Lactic acid-13C ((R)-2-Hydroxypropionic acid-13C) is a 13C-labeled D-Lactic acid. D-(-)-Lactic acid-13C can be used as an internal standard and can also be used in studies such as metabolic tracing.
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-
- HY-N0390S11
-
-
- HY-N0464S
-
-
- HY-W750144
-
|
Benzoylformic acid-13C8
|
Isotope-Labeled Compounds
Endogenous Metabolite
Drug Intermediate
|
Metabolic Disease
|
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Phenylglyoxylic acid- 13C8 (Benzoylformic acid- 13C8) is the 13C-labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds .
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-
- HY-144344S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Benzyl(2R)-3-N,N-dibenzylamino-2-fluoropropanoate- 13C3 is a 13C-labeled and deuterium labeled Benzyl(2R)-3-N,N-dibenzylamino-2-fluoropropanoate .
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-
- HY-17461S
-
-
- HY-W777928
-
|
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Cyclohexane-1,3-dione- 13C6 is the 13C-labeled Cyclohexane-1,3-dione (HY-W007466). Cyclohexane-1,3-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N0830BS
-
-
- HY-W767936
-
-
- HY-W780166
-
|
|
Reactive Oxygen Species (ROS)
|
Cardiovascular Disease
|
|
Uric acid- 13C is the 13C-labeled Uric acid (HY-B2130). Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .
|
-
- HY-W770914
-
|
|
Isotope-Labeled Compounds
GlyT
Endogenous Metabolite
|
Metabolic Disease
|
|
Stearoyl-L-carnitine chloride- 13C3 is the 13C-labeled Stearoyl-L-carnitine chloride (HY-130466). Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM .
|
-
- HY-N0830S3
-
|
|
HSP
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
Cancer
|
|
Palmitic acid-1- 13C is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
|
-
- HY-19528S1
-
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SAH (S-Adenosylhomocysteine)-13C5
|
Endogenous Metabolite
|
Metabolic Disease
|
|
SAH- 13C5 is the 13C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .
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-
- HY-B1395S1
-
|
|
Isotope-Labeled Compounds
nAChR
|
Neurological Disease
|
|
Mecamylamine (hydrochloride)- 13C4, 15N is the 13C-labeled and 15N-labeled Mecamylamine hydrochloride. Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier .
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-
- HY-79576S2
-
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Oestrone methyl ether-13C6; 3-O-Methylestrone-13C6
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Isotope-Labeled Compounds
|
Others
|
|
Estrone 3-methyl ether- 13C6 is a 13C-labeled Estrone 3-methyl ether (HY-79576). Estrone 3-methyl ether (Oestrone methyl ether; 3-O-Methylestrone) is a synthetic intermediate useful for synthesis of estrogen receptor modulator .
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-
- HY-W754982
-
|
N-Cyclohexylbenzothiazole-2-amine-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
N-Cyclohexyl-1,3-benzothiazol-2-amine- 13C6 (N-Cyclohexylbenzothiazole-2-amine- 13C6) is the 13C-labeled N-Cyclohexyl-1,3-benzothiazol-2-amine (HY-W200757).
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-
- HY-Y0479AS2
-
-
- HY-W768333
-
|
D-Ribose-13C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
|
|
D-Ribofuranose- 13C5 (D-Ribose- 13C5) is the 13C-labeled D-Ribofuranose (HY-113375). D-Ribofuranose (D-Ribose) is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Ribose 5 Phosphate Isomerase Deficiency and Medium Chain Acyl Co A Dehydrogenase Deficiency .
|
-
- HY-10065S
-
|
AG-013736-13C，d3
|
VEGFR
PDGFR
|
Cancer
|
|
Axitinib- 13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50 values of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively .
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-
- HY-N0390S10
-
-
- HY-W749528
-
-
- HY-I0096S
-
-
- HY-W756637
-
|
Dytransin-13C6
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Ibufenac- 13C6 (Dytransin- 13C6) is the 13C-labeled Ibufenac (HY-W040672). Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .
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-
- HY-B0150S1
-
|
Niacinamide-15N,13C3; Nicotinic acid amide-15N,13C3
|
Endogenous Metabolite
Sirtuin
|
Neurological Disease
Cancer
|
|
Nicotinamide- 15N, 13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
|
-
- HY-W750064
-
|
1-Phenylethan-1-One-13C8
|
Isotope-Labeled Compounds
Fungal
Drug Intermediate
|
Others
|
|
Acetophenone- 13C8 (1-Phenylethan-1-One- 13C8) is the 13C-labeled Acetophenone (HY-Y0989). Acetophenone (1-Phenylethan-1-One) is an organic compound with simple structure. Acetophenone can be bioreduced to phenylethanol (PEA) .
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-
- HY-17376S3
-
|
SCH 58235-13C6
|
Isotope-Labeled Compounds
Autophagy
Keap1-Nrf2
|
Cancer
|
|
Ezetimibe- 13C6 (SCH 58235- 13C6) is the 13C-labeled Ezetimibe (HY-17376). Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
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- HY-141578S
-
|
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Isotope-Labeled Compounds
|
Others
|
|
C18:1-Ceramide- 13C18 is a 13C-labeled C18:1-Ceramide (HY-141578). C18:1-Ceramide is a ceramide subspecies. C18:1-Ceramide can be used in the study of type 2 diabetes .
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-
- HY-W759459
-
|
2,2-Dimethyl-1,3-dioxane-4,6-dione-13C3
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Meldrum's acid- 13C3 (2,2-Dimethyl-1,3-dioxane-4,6-dione- 13C3) is the 13C-labeled Meldrum's acid (HY-Y0232). Meldrum's acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-W777188
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
6-Hydroxy Chlorzoxazone- 13C6 is a the 13C-labeled 6-Hydroxy Chlorzoxazone (HY-W016221) . 6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort .
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-
- HY-W771024
-
|
4-(4-Methylphenyl)sulfonyloxybutyl 4-methylbenzenesulfonate-13C4; NSC 521542-13C4
|
Isotope-Labeled Compounds
|
Others
|
|
Butane-1,4-diyl bis(4-methylbenzenesulfonate)- 13C4 (4-(4-Methylphenyl)sulfonyloxybutyl 4-methylbenzenesulfonate- 13C4) is the 13C-labeled Butane-1,4-diyl bis(4-methylbenzenesulfonate) (HY-Z1250).
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-
- HY-B0495S4
-
|
LTG-13C3; BW430C-13C3
|
Sodium Channel
Autophagy
|
Neurological Disease
|
|
Lamotrigine- 13C3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .
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-
- HY-B2130S
-
|
|
Reactive Oxygen Species (ROS)
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Uric acid- 13C, 15N3 is the 13C-labeled and 15N-labeled Uric acid. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .
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-
- HY-W334800S2
-
|
L-threo-2,6-Diaminopimelic acid-13C7
|
Isotope-Labeled Compounds
|
Others
|
|
(2S,6S)-2,6-Diaminoheptanedioic acid- 13C7 (L-threo-2,6-Diaminopimelic acid- 13C7) is 13C-labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).
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-
- HY-113046S
-
|
5-Methyl THF-13C5; 5-MTHF-13C,d5
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Endogenous Metabolite
|
Metabolic Disease
|
|
5-Methyltetrahydrofolic acid- 13C5 is the 13C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid .
|
-
- HY-32351AS1
-
|
25-Hydroxy Vitamin D3-13C5 monohydrate
|
Isotope-Labeled Compounds
VD/VDR
Endogenous Metabolite
|
Metabolic Disease
|
|
Calcifediol- 13C5 monohydrate is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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-
- HY-W768207
-
-
- HY-W779969
-
-
- HY-W749377
-
|
Toluene, 2,3,4,5,6-pentabromo-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,5-Pentabromo-6-methylbenzene- 13C6 (Toluene, 2,3,4,5,6-pentabromo- 13C6) is the 13C-labeled 1,2,3,4,5-Pentabromo-6-methylbenzene (HY-W274110).
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-
- HY-90009AS1
-
-
- HY-N0830S9
-
-
- HY-W769361
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
5-Hydroxymethyl-2-furancarboxylic acid- 13C6 is the 13C-labeled 5-Hydroxymethyl-2-furancarboxylic acid (HY-W005241). 5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural (HMF) in the body and eliminated renally.
|
-
- HY-W008449S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
1-Methylxanthine- 13C4, 15N3 is the 13C-labeled and 15N-labeled 1-Methylxanthine. 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP) . 1-Methylxanthine enhances the radiosensitivity of tumor cells .
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-
- HY-B0430S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Pantothenic acid- 13C3, 15N (hemicalcium) is the 13C-labeled and 15N-labeled D-Pantothenic acid. D-Pantothenic acid is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism .
|
-
- HY-W768262
-
|
Gluconic acid lactone-13C6
|
Reactive Oxygen Species (ROS)
|
Others
|
|
D-(+)-Glucono-1,5-lactone- 13C6 (Gluconic acid lactone- 13C6) is the 13C-labeled D-(+)-Glucono-1,5-lactone (HY-I0301). D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.
|
-
- HY-113407CS
-
|
|
Isotope-Labeled Compounds
Drug Intermediate
|
Metabolic Disease
|
|
D-Fructose-6-phosphate disodium monohydrate- 13C6 is the 13C-labeled D-Fructose-6-phosphate disodium monohydrate (HY-113407C). D-Fructose-6-phosphate disodium monohydrate is an intermediate of Glycolysis. D-Fructose-6-phosphate disodium monohydrate is the precursor for the synthesis of amino sugars, such as galactosamine and glucosamine .
|
-
- HY-13756S
-
|
FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2
|
Phosphatase
FKBP
Bacterial
Autophagy
Antibiotic
|
Infection
Inflammation/Immunology
Cancer
|
|
Tacrolimus- 13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
|
-
- HY-W778511
-
|
4-Oxovaleric acid-13C3; NSC 3716-13C3
|
Isotope-Labeled Compounds
Bacterial
Endogenous Metabolite
|
Infection
|
|
Levulinic acid- 13C3 (4-Oxovaleric acid- 13C) is the 13C-labeled Levulinic acid (HY-Y0839). Levulinic acid is a precursor for the synthesis of biofuels, such as ethyl levulinate. Levulinic acid is also a 5-keto-pentanoic acid. Levulinic acid can be utilized by the cells as a cosubstrate for biopolymer synthesis. Levulinic acid can be used in antibacterial research .
|
-
- HY-W766574
-
-
- HY-138615S2
-
-
- HY-W778286
-
|
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Enterolactone- 13C3 is the 13C-labeled Enterolactone (HY-108692). Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .
|
-
- HY-W654247
-
|
|
HBV
|
Infection
Cancer
|
|
Lamivudine- 13C,d2 is the deuterium labeled and 13C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
|
-
- HY-W769288
-
|
LY231514 disodium-13C5
|
Isotope-Labeled Compounds
Apoptosis
Antifolate
Autophagy
|
Cancer
|
|
Pemetrexed disodium- 13C5 (LY231514 disodium- 13C5) is the 13C-labeled Pemetrexed disodium (HY-10820A). Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .
|
-
- HY-N1150S11
-
-
- HY-W777620
-
|
rac-Cotinine-13C,d3
|
Isotope-Labeled Compounds
|
Others
|
|
1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone- 13C,d3 (rac-Cotinine- 13C,d3) is the deuterium and 13C-labeled 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (HY-W588192).
|
-
- HY-136648S5
-
|
dATP-13C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
DNA/RNA Synthesis
|
Others
|
|
2'-Deoxyadenosine-5'-triphosphate- 13C10 (dATP- 13C10) dilithium is 13C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
|
-
- HY-N0830S
-
-
- HY-W777749
-
|
8-Methoxypsoralen-13C,d3; Xanthotoxin-13C,d3; 8-MOP-13C,d3
|
Isotope-Labeled Compounds
Cytochrome P450
|
Cancer
|
|
Methoxsalen- 13C,d3 (8-Methoxypsoralen- 13C,d3) is the deuterium and 13C-labeled Methoxsalen (HY-30151). Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.
|
-
- HY-W768772
-
|
|
Isotope-Labeled Compounds
Herbicide
|
Others
|
|
Fluroxypyr- 13C2,d2 is the deuterium labeled and 13C-labeled Fluroxypyr (HY-B1842). Fluroxypyr is an auxin herbicide to control annual or perennial weeds. Fluroxypyr icauses auxin overdose or excessive endogenous auxin concentrations, thereby resulting in an imbalance of auxin homeostasis and interaction with other hormones in tissues .
|
-
- HY-N8525S
-
|
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
3'-O-Acetylthymidine- 13C is the 13C-labeled 3'-O-Acetylthymidine (HY-N8525). 3'-O-Acetylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-W048482S
-
|
DMT-2'O-TBDMS-rU phosphoramidite-13C2,d1
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
|
rU Phosphoramidite- 13C2,d1 (DMT-2'O-TBDMS-rU phosphoramidite- 13C2,d1) is deuterium and 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-W748688
-
|
Acetylsulfamethoxazole-13C6
|
Isotope-Labeled Compounds
Bacterial
Drug Metabolite
|
Infection
|
|
N4-Acetylsulfamethoxazole- 13C6 (Acetylsulfamethoxazole- 13C6) is the 13C-labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of?Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections .
|
-
- HY-B2176S2
-
|
Adenosine 5'-triphosphate-13C dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
|
ATP- 13C (Adenosine 5'-triphosphate- 13C) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
|
-
- HY-W777706
-
|
1-(3,4-Dimethylphenyl)ethanol-13C,d3
|
Isotope-Labeled Compounds
|
Others
|
|
1-(3,4-Dimethylphenyl)ethan-1-ol- 13C,d3 (1-(3,4-Dimethylphenyl)ethanol- 13C,d3) is the deuterium labeled and 13C-labeled 1-(3,4-Dimethylphenyl)ethan-1-ol (HY-W340128).
|
-
- HY-B2176S6
-
|
Adenosine 5'-triphosphate-13C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
|
ATP- 13C10 (Adenosine 5'-triphosphate- 13C10) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
|
-
- HY-18085S2
-
-
- HY-15407S3
-
|
AHU-377-13C4
|
Isotope-Labeled Compounds
Neprilysin
|
Infection
|
|
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .
|
-
- HY-128417S2
-
-
- HY-W770250
-
|
|
Isotope-Labeled Compounds
Insecticide
|
Others
|
|
Clothianidin-d3, 13C1 is the 13C-labeled Clothianidin (HY-133167). Clothianidin is a neonicotinoid insecticide. Clothianidin shows excellent long-term control effect in small doses against various insect pests such as Coleoptera, Thysanoptera, Lepidoptera, Diptera, Homoptera, Heteroptera, Orthoptera and Isoptera families. Clothianidin has various application methods and high safety for crops .
|
-
- HY-14605BS
-
|
AGN1135-13C3; TVP1012-13C3 racemic
|
Isotope-Labeled Compounds
Monoamine Oxidase
|
Neurological Disease
|
|
Rasagiline- 13C3 (mesylate racemic) is a 13C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor . Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W101495S
-
-
- HY-W749519
-
|
trans,trans-Farnesol-13C3; (2E,6E)-Farnesol-13C3
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
(E,E)-Farnesol- 13C3 (trans,trans-Farnesol- 13C3) is the 13C-labeled (E,?E)?-?Farnesol (HY-Y0248). (E, E)-Farnesol (trans,trans-Farnesol;(2E,6E)-Farnesol) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-101400S4
-
-
- HY-W751526
-
|
Sulfamethazine-n4-acetyl-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
N4-Acetylsulfamethazine- 13C6 (Sulfamethazine-n4-acetyl- 13C6) is the 13C-labeled N4-Acetylsulfamethazine (HY-W290839). N4-Acetylsulfamethazine is a metabolite of Sulfamethazine (HY-B0035). Sulfamethazine is one of the most frequently used sulfonamides in the poultry farming industry .
|
-
- HY-W778288
-
|
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
(±)-Enterodiol- 13C3 is the 13C-labeled (±)-Enterodiol (HY-108695B). (±)-Enterodiol is the racemate of Enterodiol (HY-108695). Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Enterodiol has anti-cancer activities .
|
-
- HY-W008452S
-
-
- HY-107372S2
-
-
- HY-66005S3
-
-
- HY-113008AS
-
|
(Z)-Urocanic acid-13C3; cis-UCA-13C3
|
Isotope-Labeled Compounds
5-HT Receptor
|
Inflammation/Immunology
|
|
cis-Urocanic acid- 13C3 is the 13C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor .
|
-
- HY-W754216
-
|
2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Diacetone-β-D-fructose- 13C6 (2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose- 13C6) is the 13C-labeled Diacetone-β-D-fructose (HY-W011792). Diacetone-β-D-fructose is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-W768188
-
|
D-Arabinitol-1,2-13C2
|
Isotope-Labeled Compounds
|
Others
|
|
(2r,4r)-Pentane-1,2,3,4,5-pentaoll- 13C2 (D-Arabinitol-1,2- 13C2) is the 13C-labeled (2r,4r)-Pentane-1,2,3,4,5-pentaol (HY-W794625).
|
-
- HY-B0495S
-
|
LTG-13C3,d3; BW430C-13C3,d3
|
Isotope-Labeled Compounds
Sodium Channel
Autophagy
|
Neurological Disease
|
|
Lamotrigine- 13C3,d3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .
|
-
- HY-101981S4
-
|
5'-Uridylic acid-13C9 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Uridine 5'-monophosphate- 13C9 (5'- Uridylic acid- 13C9) dilithium is 13C-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'- Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-W778954
-
|
(2,2-Dimethyl-[1,3] dioxane-4-yl)-methanol-13C3; (4RS)-2,2-Dimethyl-1,3-dioxolane-4-methanol-13C3; (RS)-Solketal-13C3; (±)-1,2-O-Isopropylideneglycerol-13C3; (±)-2,2-Dimethyl-1,3-dioxolane-4-methanol-13C3; (±)-Glycerol 1,2-acetonide-13C3; Solketa-13C3l
|
Isotope-Labeled Compounds
|
Others
|
|
2,2-Dimethyl-1,3-dioxolane-4-methanol- 13C3 ((2,2-Dimethyl-[1,3] dioxane-4-yl)-methanol- 13C3) is the 13C-labeled 2,2-Dimethyl-1,3-dioxolane-4-methanol (HY-Y1372).
|
-
- HY-W768839
-
|
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
5-(Hydroxymethyl)cytidine- 13C,d2 is the deuterium labeled and 13C-labeled 5-(Hydroxymethyl)cytidine (HY-152854). 5-(Hydroxymethyl)cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-W747791
-
|
s-Triazine, 2-amino-4,6-dichloro-13C3; 2-Amino-4,6-dichloro-s-triazine-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
4,6-Dichloro-1,3,5-triazin-2-amine- 13C3 (s-Triazine, 2-amino-4,6-dichloro- 13C3) is the 13C-labeled 4,6-Dichloro-1,3,5-triazin-2-amine (HY-W008081).
|
-
- HY-B2033S
-
|
|
Isotope-Labeled Compounds
Fungal
|
Infection
|
|
Pyrimethanil- 13C, 15N2 is the 13C-labeled and 15N-labeled Pyrimethanil. Pyrimethanil is an?anilinopyrimidine?and broad-spectrum?contact fungicide for the control of Botrytis spp. on a wide variety of crops . Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in?Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection .
|
-
- HY-W748430
-
|
Furazidine-13C3; Furazidin-13C3
|
Isotope-Labeled Compounds
Carbonic Anhydrase
Bacterial
Antibiotic
|
Infection
|
|
Furagin- 13C3 (Furazidine- 13C3) is the 13C-labeled Furagin (HY-77036). Furagin (Furazidine), an analogue of Nitrofurantoin (HY-A0090), is an antibiotic with antibacterial activity against ESKAPE pathogens with MIC values of 0-32 μg/mL. Furagin inhibits human Carbonic anhydrases . Furagin is promising for research of cancer and urinary tract infections (UTIs) .
|
-
- HY-W766388
-
|
D-Glucosamine Hydrochloride-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
2-Amino-2-deoxyglucose hydrochloride- 13C6 (D-Glucosamine Hydrochloride- 13C6) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
|
-
- HY-W777762
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Dodecanedioic Acid- 13C12 is the 13C-labeled Dodecanedioic acid (HY-W012241). Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus .
|
-
- HY-W751834
-
|
NSC 99321-13C3; 6-Amino-5-nitrouracil-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
6-Amino-5-nitropyrimidine-2,4(1H,3H)-dione- 13C3 (NSC 99321- 13C3) is the 13C-labeled 6-Amino-5-nitropyrimidine-2,4(1H,3H)-dione (HY-W016913).
|
-
- HY-A0181S3
-
|
AMP-13C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
Adenosine Receptor
HSV
|
Infection
Metabolic Disease
|
|
Adenosine monophosphate- 13C10 (AMP- 13C10) dilithium is 13C-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction .
|
-
- HY-W654255
-
|
(±)-Mandelic acid-13C8; DL-Mandelic acid-13C8
|
Isotope-Labeled Compounds
Bacterial
Endogenous Metabolite
|
Infection
|
|
Mandelic Acid- 13C8 ((±)-Mandelic acid- 13C8) is the 13C-labeled Mandelic acid (HY-W015591). Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation .
|
-
- HY-W016009S3
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
2'-Deoxyadenosine-5'-monophosphate- 13C10 dilithium is 13C-labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
|
-
- HY-W777526
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Nitisinone- 13C6 is a 13C-labeled Nitisinone (HY-B0607). Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .
|
-
- HY-W755778
-
|
|
Isotope-Labeled Compounds
Trace Amine-associated Receptor (TAAR)
|
Metabolic Disease
|
|
3-Iodothyronamine hydrochloride- 13C6 is the 13C-labeled 3-Iodothyronamine hydrochloride (HY-135065). 3-Iodothyronamine hydrochloride is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure .
|
-
- HY-W778179
-
|
LRCL 3794-13C,d3
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Benoxaprofen- 13C,d3 (LRCL 3794- 13C,d3) is the deuterium and 13C-labeled Benoxaprofen (HY-13568). Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation .
|
-
- HY-W779191
-
|
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline-2-13C
|
Isotope-Labeled Compounds
Cytochrome P450
|
Cancer
|
|
MeIQx- 13C (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline-2- 13C) is the 13C-labeled MeIQx (HY-W355129). MeIQx, a dietary aromatic amine, is mutagenic compound could be isolated from present in fried beef and beef extracts. MeIQx binds covalently to hemoglobin. MeIQx induces liver tumors .
|
-
- HY-B0636S1
-
|
|
Isotope-Labeled Compounds
Glucocorticoid Receptor
FGFR
|
Cardiovascular Disease
Inflammation/Immunology
Endocrinology
Cancer
|
|
Triamcinolone acetonide- 13C3 is the 13C-labeled Triamcinolone acetonide (HY-B0636). Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis .
|
-
- HY-W767186
-
|
|
Isotope-Labeled Compounds
Hexokinase
|
Metabolic Disease
Cancer
|
|
D-Mannoheptulose- 13C7 is the 13C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .
|
-
- HY-W281364S
-
|
|
Isotope-Labeled Compounds
MDM-2/p53
|
Cancer
|
|
2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine- 13C is the 13C-labeled 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine (HY-W281364). 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine is a mutagenic compound .
|
-
![2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine-13C](//file.medchemexpress.eu/product_pic/hy-w281364s.gif)
- HY-W768482
-
|
2-Amino-6-hydroxy-1H-pyrimidin-4-one-13C2; 2-Amino-4,6-dihydroxypyrimidine-13C2
|
Isotope-Labeled Compounds
|
Others
|
|
2-Amino-6-hydroxypyrimidin-4(1H)-one- 13C2 (2-Amino-6-hydroxy-1H-pyrimidin-4-one- 13C2) is the 13C-labeled 2-Amino-6-hydroxypyrimidin-4(1H)-one (HY-Y0559).
|
-
- HY-W009162S1
-
|
5'-Cytidylic acid-13C9 dilithium; 5'-CMP-13C9 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Cytidine 5′-monophosphate- 13C9 (5'-Cytidylic acid- 13C9 dilithium; 5'-CMP- 13C9) dilithium is 13C-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
|
-
- HY-W010918S3
-
|
Adenosine diphosphate-13C5; ADP-13C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Adenosine 5'-diphosphate- 13C5 (Adenosine diphosphate- 13C5) is the 13C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
|
-
- HY-W778240
-
|
Naphthalene-2-carboxylic acid-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
2-Naphthoic acid- 13C6 (Naphthalene-2-carboxylic acid- 13C6) is the 13C-labeled 2-Naphthoic acid (HY-W007437). 2-Naphthoic acid is an organic compound commonly used as a raw material for dyes and the production of other chemicals. It can form dyes with other organic substances and is widely used in textile, printing and manufacturing fields. In addition, the compound is also used as a photosensitive material and a lubricant.
|
-
- HY-N5134S1
-
|
5'-GMP-13C10 dilithium; 5'-guanosine monophosphate-13C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
5'-Guanylic acid- 13C10 (5'-GMP- 13C10 dilithium; 5'-guanosine monophosphate- 13C10) dilithium is 13C-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
|
-
- HY-W748418
-
|
|
Isotope-Labeled Compounds
Liposome
|
Others
|
|
1-Thio-β-D-glucose Sodium Salt Dihydrate- 13C6 is the 13C-labeled 1-Thio-β-D-glucose sodium (HY-115419). 1-Thio-β-D-glucose sodium is the sodium salt form of 1-Thio-β-D-glucose. 1-Thio-β-D-glucose forms hydrophilic self-assembled monolayer with metal, stablizes the lipid bilayer and protects the proteins from denaturation .
|
-
- HY-W751156
-
|
L-Serine O-phosphate-13C3; L-SOP-13C3
|
Isotope-Labeled Compounds
mGluR
Endogenous Metabolite
|
Neurological Disease
|
|
O-Phospho-L-serine- 13C3 (L-Serine O-phosphate- 13C3) is the 13C-labeled O-Phospho-L-serine (HY-15129). O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .
|
-
- HY-W748519
-
|
N-Methylglycine-13C3; Sarcosin-13C3
|
Isotope-Labeled Compounds
GlyT
Endogenous Metabolite
|
Cancer
|
|
Sarcosine- 13C3 (N-Methylglycine- 13C3; Sarcosin- 13C3) is the 13C-labeled Sarcosine (HY-101037). Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .
|
-
- HY-N0322S4
-
|
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Metabolic Disease
|
|
Cholesterol- 13C3 is the 13C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .
|
-
- HY-116084S1
-
-
- HY-N6786S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Ochratoxin B- 13C20 is 13C-labeled Ochratoxin B (HY-N6786). Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .
|
-
- HY-W768178
-
|
D-Glucosamine Hydrochloride-1,2-13C2
|
Isotope-Labeled Compounds
|
Others
|
|
2-Amino-2-deoxyglucose hydrochloride- 13C2 (D-Glucosamine Hydrochloride-1,2- 13C2) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
|
-
- HY-W777120
-
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R 51619-13C,d3; (±)-Cisaprid-13C,d3
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Isotope-Labeled Compounds
5-HT Receptor
Potassium Channel
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Neurological Disease
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Cisapride- 13C,d3 (R 51619- 13C,d3) is the deuteriumand 13C-labeled Cisapride (HY-14149). Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. Cisapride is a hERG blocker with an IC50 value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity .
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- HY-W747879
-
|
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Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
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Diclofenac Amide- 13C6 is the 13C-labeled Diclofenac amide (HY-134521). Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) .
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- HY-18572S
-
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2,4-Dichlorophenoxyacetic acid-13C6
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Isotope-Labeled Compounds
DNA/RNA Synthesis
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Others
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2,4-D- 13C6 is the 13C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development .
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-
- HY-W759219
-
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(+)-Adrenosterone-13C3; 11-Keto-androstedione-13C3
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Isotope-Labeled Compounds
Endogenous Metabolite
Androgen Receptor
|
Endocrinology
|
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Adrenosterone- 13C3 ((+)-Adrenosterone- 13C3) is the 13C-labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor.
Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .
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-
- HY-B0152S3
-
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6-Aminopurine-13C5; Vitamin B4-13C5
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Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
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Adenine- 13C5 (6-Aminopurine- 13C5; Vitamin B4- 13C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA.
Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
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-
- HY-129503S
-
|
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
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2-Heptyl-4-quinolone- 13C6 is the 13C-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .
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-
- HY-W777281
-
|
|
Isotope-Labeled Compounds
Glucocorticoid Receptor
Wnt
|
Endocrinology
|
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Fluocinolone acetonide- 13C3 is the 13C-labeled Fluocinolone (Acetonide) (HY-B0415). Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015) .
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-
- HY-W749825
-
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Diethylenetriaminepentaacetic acid-13C5; DTPA-13C5
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Isotope-Labeled Compounds
Fluorescent Dye
|
Others
|
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Pentetic acid- 13C5 (Diethylenetriaminepentaacetic acid- 13C5) is the 13C-labeled Pentetic acid (HY-B1335). Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide .
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-
- HY-136380S
-
|
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Isotope-Labeled Compounds
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Others
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Clodinafop-propargyl- 13C6 is the 13C-labeled Clodinafop-propargyl. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl-13C6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-N0322S3
-
|
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Metabolic Disease
|
|
Cholesterol- 13C5 is the 13C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .
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-
- HY-W765245
-
|
Sirolimus-13C,d3-1; AY-22989-13C,d3-1
|
Isotope-Labeled Compounds
Fungal
mTOR
Bacterial
Autophagy
Endogenous Metabolite
FKBP
Antibiotic
|
Cancer
|
|
Rapamycin- 13C,d3-1 (Sirolimus- 13C,d3-1) is the deuterium labeled and 13C-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .
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- HY-B1804S
-
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Trioctanoin-13C3; Glyceryl trioctanoate-13C3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
Inflammation/Immunology
|
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Tricaprilin- 13C3 (Trioctanoin- 13C3) is a 13C-labeled Tricaprilin (HY-B1804) . Tricaprilin is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .
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-
- HY-N1428S1
-
-
- HY-W753181
-
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L-(-)-3-Phenyllactic Acid-13C9
|
Isotope-Labeled Compounds
Fungal
Endogenous Metabolite
|
Metabolic Disease
|
|
(S)-2-Hydroxy-3-phenylpropanoic acid- 13C9 (L-(-)-3-Phenyllactic Acid- 13C9) is the 13C-labeled (S)-2-Hydroxy-3-phenylpropanoic acid (HY-30220). (S)-2-Hydroxy-3-phenylpropanoic acid is the L-configuration of 2-Hydroxy-3-phenylpropanoic acid, and its level is closely related to some diseases, such as phenylketonuria .
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-
- HY-N0086S2
-
|
6-Methyladenosine-13C4; N-Methyladenosine-13C4
|
Isotope-Labeled Compounds
Influenza Virus
Endogenous Metabolite
|
Infection
|
|
N6-Methyladenosine- 13C4 (6-Methyladenosine- 13C4; N-Methyladenosine- 13C4) is 13C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.
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-
- HY-W750959
-
|
H-Met(O)-OH-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Methionine sulfoxide- 13C (H-Met(O)-OH- 13C) is the 13C-labeled L-Methionine sulfoxide (HY-W010104). L-Methionine sulfoxide is an orally active oxidation product of Methionine (HY-N0326). L-Methionine sulfoxide can be partially converted into Methionine in the body and participate in the synthesis of glutathione in the liver. L-Methionine sulfoxide provides the body with sulfur activity and can participate in the synthesis of proteins and sulfur-containing compounds .
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-
- HY-N0086S3
-
|
6-Methyladenosine-13C3; N-Methyladenosine-13C3
|
Isotope-Labeled Compounds
Influenza Virus
Endogenous Metabolite
|
Infection
|
|
N6-Methyladenosine- 13C3 (6-Methyladenosine- 13C3) is 13C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities .
|
-
- HY-N1428S3
-
-
- HY-W778335
-
|
DMP-13C2
|
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
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Dimethyl Phthalate- 13C2 (DMP- 13C2) is the 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
|
-
- HY-13653S
-
|
|
Oxidative Phosphorylation
Autophagy
Reactive Oxygen Species (ROS)
HIV
Ferroptosis
Mitochondrial Metabolism
Endogenous Metabolite
|
Cancer
|
|
(+/-)-Epigallocatechin Gallate- 13C3 is the 13C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects . (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.
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- HY-15037S
-
|
|
Isotope-Labeled Compounds
COX
Apoptosis
|
Inflammation/Immunology
|
|
Diclofenac- 13C6 (sodium heminonahydrate) is the 13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
|
-
- HY-W747751
-
|
|
Isotope-Labeled Compounds
Fungal
IGF-1R
Bacterial
Endogenous Metabolite
Antibiotic
|
Infection
|
|
Sorbic acid- 13C2 is the 13C-labeled Sorbic acid (HY-N0626). Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways .
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-
- HY-W754236
-
|
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Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-Carnitine Hydrochloride- 13C3 is the 13C-labeled L-Carnitine hydrochloride (HY-B2246). L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .
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-
- HY-A0067S1
-
|
Benzophenone 3-13C6
|
Isotope-Labeled Compounds
RAR/RXR
Autophagy
Apoptosis
|
Neurological Disease
|
|
Oxybenzone- 13C6 (Benzophenone 3- 13C6) is the 13C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
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-
- HY-128393S1
-
|
|
Isotope-Labeled Compounds
PI3K
Akt
E-Selectin
Apoptosis
MMP
MEK
ERK
|
Cancer
|
|
Trilinolein- 13C54 is the 13C-labeled Trilinolein (HY-128393). Trilinolein is an orally active triglyceride that inhibits the PI3K/Akt, Ras/MEK/ERK signaling pathways, and MMP-2. Trilinolein can reduce oxidative stress, induce apoptosis, and inhibit cell migration. Trilinolein can be used in the research fields of cardiovascular disease, cerebrovascular disease (such as cerebral ischemia), and non-small cell lung cancer .
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-
- HY-W777169
-
|
LGD1069-13C4
|
Isotope-Labeled Compounds
RAR/RXR
Autophagy
|
Cancer
|
|
Bexarotene- 13C4 (LGD1069- 13C4) is the 13C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
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-
- HY-B0166S1
-
-
- HY-B0228S13
-
-
- HY-B0113S3
-
|
H 16868-13C,d3
|
Isotope-Labeled Compounds
Proton Pump
Autophagy
Bacterial
Phospholipase
|
Infection
Metabolic Disease
Cancer
|
|
Omeprazole- 13C,d3 is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
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-
- HY-B0166S
-
-
- HY-W778242
-
|
3,4-Dihydro-1(2H)-naphthalenon-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
3,4-Dihydronaphthalen-1-one- 13C6 (3,4-Dihydro-1(2H)-naphthalenon- 13C6) is the 13C-labeled 3,4-Dihydronaphthalen-1(2H)-one (HY-76194). 3,4-Dihydronaphthalen-1(2H)-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-W766136
-
|
2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenyl-4-[(2-N-methoxycarbonyl)acetamidrazono]morpholine-13C2,d2
|
Isotope-Labeled Compounds
|
Others
|
|
Aprepitant Impurity 9- 13C2,d2 (2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenyl-4-[(2-N-methoxycarbonyl)acetamidrazono]morpholine- 13C2,d2) is the deuterium labeled and 13C-labeled Aprepitant Impurity 9 (HY-Z11099).
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-
- HY-W009300S1
-
|
4-OHE1-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
4-Hydroxyestrone- 13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .
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-
- HY-N7106S3
-
|
DMP-13C6
|
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Dimethyl phthalate- 13C6 (DMP- 13C6) is the 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
|
-
- HY-W127841
-
-
- HY-W008048S
-
|
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
2',3'-O-Isopropylideneadenosine- 13C5 is the 13C-labeled 2',3'-O-Isopropylideneadenosine (HY-W008048). 2',3'-O-Isopropylideneadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
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-
- HY-W751180
-
|
CGP52421-13C6
|
Isotope-Labeled Compounds
FLT3
|
Cancer
|
|
3-Hydroxy Midostaurin- 13C6 (CGP52421- 13C6) is the 13C-labeled 3-Hydroxy Midostaurin (HY-108263). 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .
|
-
- HY-W654296
-
|
|
Isotope-Labeled Compounds
PPAR
Cytochrome P450
Biochemical Assay Reagents
Estrogen Receptor/ERR
|
Others
|
|
Octocrylene- 13C3 is the 13C-labeled Octocrylene (HY-A0087). Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes .
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-
- HY-W777084
-
|
(E)-O-Methylferulic acid-13C3
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
(E)-3,4-Dimethoxycinnamic acid- 13C3 ((E)-O-Methylferulic acid- 13C3) is the 13C-labeled (E)-3,4-Dimethoxycinnamic acid (HY-N1778A). (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .
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-
- HY-W747676
-
|
|
Isotope-Labeled Compounds
Apoptosis
Autophagy
Necroptosis
|
Neurological Disease
|
|
Glyphosate- 13C is the 13C-labeled Glyphosate (HY-B0863). Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .
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-
- HY-16938S
-
|
5'-(Methylthio)-5'-deoxyadenosine-13C6; 5'-Deoxy-5'-(methylthio)adenosine-13C6; 5'-S-Methyl-5'-thioadenosine-13C6
|
Endogenous Metabolite
Apoptosis
|
Metabolic Disease
Cancer
|
|
5'-Methylthioadenosine- 13C6 is the 13C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .
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-
- HY-A0181S
-
|
AMP-13C10,15N5 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
Adenosine Receptor
HSV
|
Infection
Metabolic Disease
|
|
Adenosine monophosphate- 13C10, 15N5(AMP- 13C10, 15N5) is the 13C-labeled and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction .
|
-
- HY-151997S
-
|
1,2-Olein-3-laurin-13C3; TG(18:1/18:1/12:0)-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-Dioleoyl-3-lauroyl-rac-glycerol- 13C3 is the 13C-labeled 1,2-Dioleoyl-3-lauroyl-rac-glycerol (HY-165089), 1,2-Dioleoyl-3-lauroyl-rac-glycerol (1,2-Olein-3-laurin) is a triglyceride identified by specific analytical methods in human milk, infant formula, other mammalian milk, and vegetable oils, with specific structural and distribution characteristics.
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-
- HY-138616S3
-
|
2'-Deoxyguanosine-5'-triphosphate-13C10 dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
|
Infection
Cancer
|
|
dGTP- 13C10 (2'-Deoxyguanosine-5'-triphosphate- 13C10) dilithium is 13C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
|
-
- HY-W738273
-
|
3,4-Dimethoxybenzoic acid-13C
|
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Veratric acid- 13C (3,4-Dimethoxybenzoic acid- 13C) is the 13C-labeled Veratric acid (HY-N2007). Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities . Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling . Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation .
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-
- HY-107867S2
-
|
|
Isotope-Labeled Compounds
P2Y Receptor
|
Cardiovascular Disease
|
|
Clopidogrel- 13C,d3 sulfate is the deuterium and 13C-labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .
|
-
- HY-W768336
-
|
D-Gluconic acid-13C6 sodium; D-Gluconate-13C6 sodium
|
Isotope-Labeled Compounds
Interleukin Related
ERK
NO Synthase
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Gluconate sodium- 13C6 (D-Gluconic acid sodium salt- 13C6) is the 13C-labeled Gluconate sodium (HY-B1092A). Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury .
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-
- HY-W011012S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Adenosine 5'-monophosphate- 13C (disodium) is a 13C-labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .
|
-
- HY-W749394
-
|
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
|
|
4-Methyl-5-thiazoleethanol- 13C3 is the 13C-labeled 4-Methyl-5-thiazoleethanol (HY-W015695). 4-Methyl-5-thiazoleethanol is a natural sulfur-containing flavor compound with the aroma of beef and nuts. In addition, the composite material prepared by modifying graphene oxide with 4-Methyl-5-thiazoleethanol through a one-step esterification reaction can selectively adsorb copper ions (Cu2+) in aqueous solutions .
|
-
- HY-W738270
-
|
3,4-Dimethoxy[7-13C]-benzaldehyde
|
Isotope-Labeled Compounds
Bacterial
Parasite
|
Infection
|
|
Veratraldehyde- 13C (3,4-Dimethoxy[7- 13C]-benzaldehyde) is the 13C-labeled Veratraldehyde (HY-N1096). Veratraldehyde is an orally active aromatic compound and antibacterial agent. Veratraldehyde can be isolated from essential oils of plants such as peppermint and ginger. Veratraldehyde targets the PilY1 protein. Veratraldehyde has antibacterial activity against Pseudomonas aeruginosa. Veratraldehyde has a repellent effect against mosquitoes and ticks. Veratraldehyde can be used as a flavoring agent .
|
-
- HY-W753345
-
|
2,6-Dichloro-N-phenylaniline-13C6
|
Isotope-Labeled Compounds
Bacterial
|
Cancer
|
|
2,6-Dichlorodiphenylamine- 13C6 (2,6-Dichloro-N-phenylaniline- 13C6) is the 13C-labeled 2,6-Dichlorodiphenylamine (HY-W012126). 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a?COX?inhibitor, with?IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
|
-
- HY-W777959
-
|
|
Isotope-Labeled Compounds
5-HT Receptor
|
Neurological Disease
|
|
Azasetron Hydrochloride- 13C,d3 is the deuterium and 13C-labeled Azasetron (HY-B0019). Azasetron ((Rac)-SENS-401 free base) is an antiemetic drug with 5-HT3 receptor antagonist activity. Azasetron is often used as a preventive measure for postoperative nausea and vomiting or chemotherapy-induced nausea and vomiting. Azasetron does not impair neutrophil chemotaxis or phagocytosis and does not scavenge O(-)(2) or H(2)O(2) generated by cell-free systems .
|
-
- HY-W266188
-
|
|
Isotope-Labeled Compounds
iGluR
Tyrosinase
c-Met/HGFR
Glutaminase
|
Neurological Disease
Metabolic Disease
Cancer
|
|
Decanoic acid- 13C is the 13C-labeled Decanoic acid (HY-W015309). Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy .
|
-
- HY-114293S4
-
|
Acetyl-CoA-13C2-1 sodium
|
Isotope-Labeled Compounds
Autophagy
Endogenous Metabolite
Oxidative Phosphorylation
|
Cardiovascular Disease
|
|
Acetyl coenzyme A- 13C2-1 sodium (Acetyl-CoA- 13C2-1 sodium) is the 13C-labeled Acetyl coenzyme A (HY-114293). Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis .
|
-
- HY-12516S2
-
|
Org-2969-13C2,d2-1
|
Isotope-Labeled Compounds
Progesterone Receptor
|
Others
|
|
Desogestrel- 13C2,d2-1 (Org-2969- 13C2,d2-1) is the deuterium labeled and 13C-labeled Desogestrel (HY-12516). Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
|
-
- HY-N0215S8
-
|
(S)-2-Amino-3-phenylpropionic acid-13C6
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C6 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
|
-
- HY-N0215S10
-
|
(S)-2-Amino-3-phenylpropionic acid-13C9
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C9 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
|
-
- HY-W754064
-
|
Cytidine triphosphate-13C5; 5'-CTP-13C5; Cytidine-5'-triphosphate-1',2',3',4',5'-13C5 Triethylamine Salt
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Endogenous Metabolite
|
Metabolic Disease
|
|
Cytidine-5'-triphosphate- 13C5 (Cytidine triphosphate- 13C5) is the 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii .
|
-
- HY-N0215S7
-
|
(S)-2-Amino-3-phenylpropionic acid-3-13C
|
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine-3- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
|
-
- HY-N0411S4
-
|
Provitamin A-13C10; beta-Carotene-13C10
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
Reactive Oxygen Species (ROS)
|
Metabolic Disease
Cancer
|
|
β-Carotene- 13C10 (Provitamin A- 13C10) is the 13C-labeled β-Carotene (HY-N0411). β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .
|
-
- HY-N0215S2
-
|
(S)-2-Amino-3-phenylpropionic acid-13C
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
|
-
- HY-W751181
-
|
CGP62221-13C6; O-Desmethyl PKC412-13C6
|
Isotope-Labeled Compounds
PKC
|
Cancer
|
|
O-Desmethyl midostaurin- 13C6 (CGP62221- 13C6; O-Desmethyl PKC412- 13C6) is the 13C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor?with?IC50?ranging from 22-500 nM.
|
-
- HY-W767601
-
|
L-Lactide-13C2
|
Isotope-Labeled Compounds
|
Others
|
|
(3S,6S)-3,6-Dimethyl-1,4-dioxane-2,5-dione- 13C2 (L-Lactide- 13C2) is the 13C-labeled L-Lactide (HY-W020691A). (3S,6S)-3,6-Dimethyl-1,4-dioxane-2,5-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N2362S
-
|
DL-2-Aminopropionic acid-13C-1
|
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-Alanine- 13C-1 is the 13C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver .
|
-
- HY-W768934
-
|
L-Gulonolactone-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Gulono-1,4-lactone- 13C6 (L-Gulonolactone- 13C6) is the 13C-labeled L-Gulono-1,4-lactone (HY-W016628). L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
|
-
- HY-113066S1
-
|
GDP-13C10 dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
Potassium Channel
|
Inflammation/Immunology
|
|
Guanosine 5'-diphosphate- 13C10 (GDP- 13C10) dilithium is 13C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
|
-
- HY-N2362S1
-
|
DL-2-Aminopropionic acid-13C-3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-Alanine- 13C-3 is the 13C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver .
|
-
- HY-W753201
-
|
5'-(Methylthio)-5'-deoxyadenosine-13C; 5'-Deoxy-5'-(methylthio)adenosine-13C; 5'-S-Methyl-5'-thioadenosine-13C
|
Isotope-Labeled Compounds
Apoptosis
Parasite
Endogenous Metabolite
|
Cancer
|
|
5'-Methylthioadenosine- 13C (5'-(Methylthio)-5'-deoxyadenosine- 13C) is the 13C-labeled 5'-Methylthioadenosine (HY-16938). 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .
|
-
- HY-112499S1
-
|
Vitamin K2-7-13C6; Vitamin K2(35)-13C6; Vitamin MK-7-13C6
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .
|
-
- HY-W754400
-
|
1,6-Anhydro-β-D-mannopyranose-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Mannosan,95%- 13C6 (1,6-Anhydro-β-D-mannopyranose- 13C6) is the 13C-labeled Mannosan,95% (HY-124095). Mannosan,95% (1,6-Anhydro-β-D-mannopyranose,95%) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-N7106S2
-
|
DMP-13C6,d4
|
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Dimethyl phthalate- 13C6,d4 (DMP- 13C6,d4) is the deuterium labeled and 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
|
-
- HY-12033S1
-
|
2-ME2-13C6; NSC-659853-13C6
|
Isotope-Labeled Compounds
Microtubule/Tubulin
Reactive Oxygen Species (ROS)
Apoptosis
Autophagy
Endogenous Metabolite
|
Cancer
|
|
2-Methoxyestradiol- 13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .
|
-
- HY-W040329S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Nucleoside Antimetabolite/Analog
Caspase
Apoptosis
|
Metabolic Disease
Endocrinology
Cancer
|
|
2'-Deoxyadenosine- 13C10 is 13C-labeled 2'-Deoxyadenosine (HY-W040329) . 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .
|
-
- HY-W777365
-
|
EDTA-13C4
|
Isotope-Labeled Compounds
Bacterial
SOD
Biochemical Assay Reagents
|
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Ethylenediaminetetraacetic acid- 13C4 (EDTA- 13C4) is the 13C-labeled Ethylenediaminetetraacetic acid (HY-Y0682). Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .
|
-
- HY-W750674
-
|
3-Formylindole-C13C8
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Indole-3-carboxaldehyde- 13C8 (3-Formylindole- 13C8) is the 13C-labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde, a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract .
|
-
- HY-B0152S2
-
|
6-Aminopurine-13C5,15N5; Vitamin B4-13C5,15N5
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
|
Adenine- 13C5,15C5 (6-Aminopurine- 13C5,15C5; Vitamin B4- 13C5,15C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
|
-
- HY-W777458
-
|
|
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Fluorene- 13C6 is the 13C-labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .
|
-
- HY-B0822S1
-
|
|
GABA Receptor
Cytochrome P450
|
Inflammation/Immunology
|
|
Fipronil- 13C6 is the 13C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.
|
-
- HY-W738271
-
|
3,4-Dimethoxybenzyl alcohol-13C
|
Isotope-Labeled Compounds
Bacterial
Endogenous Metabolite
|
Infection
|
|
Veratryl alcohol- 13C (3,4-Dimethoxybenzyl alcohol- 13C) is the 13C-labeled Veratryl alcohol (HY-107858). Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H2O2 and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy .
|
-
- HY-125818S3
-
|
Cytidine triphosphate-13C9 dilithium; 5'-CTP-13C9 dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Infection
Cancer
|
|
Cytidine-5'-triphosphate- 13C9 (Cytidine triphosphate- 13C9 dilithium; 5'-CTP- 13C9) dilithium is 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
|
-
- HY-16561S1
-
|
trans-Resveratrol-13C6; SRT501-13C6
|
Isotope-Labeled Compounds
IKK
Autophagy
Mitophagy
Sirtuin
Apoptosis
Bacterial
Fungal
Antibiotic
Keap1-Nrf2
|
Infection
Inflammation/Immunology
Cancer
|
|
Resveratrol- 13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
|
-
- HY-W751179
-
|
PKC412-13C6; CGP 41251-13C6
|
Isotope-Labeled Compounds
Apoptosis
VEGFR
PKC
c-Kit
NO Synthase
|
Cancer
|
|
Midostaurin- 13C6 (PKC412- 13C6) is the 13C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .
|
-
- HY-78726S2
-
|
Amprenavir phosphate-13C6; GW 433908-13C6
|
Isotope-Labeled Compounds
Drug Intermediate
HIV
HIV Protease
|
Infection
|
|
Fosamprenavir- 13C6 is the 13C-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .
|
-
- HY-W777393
-
|
7-Hydroxycoumarin-13C6; Hydrangin-13C6; NSC 19790-13C6
|
Isotope-Labeled Compounds
Apoptosis
Fluorescent Dye
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Umbelliferone- 13C6 (7-Hydroxycoumarin- 13C6) is the 13C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in
chronic alcohol-fed rats .
|
-
- HY-W756467
-
|
1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid-13C,d3
|
Isotope-Labeled Compounds
Bacterial
Drug Intermediate
|
Infection
|
|
Antibacterial agent 265- 13C,d3 (1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid- 13C,d3) is the deuterium labeled and 13C-labeled Antibacterial agent 265 (HY-W018629). Antibacterial agent 265 (Compound 2) is an antibacterial agent. Antibacterial agent 265 shows antibacterial activity against Staphylococcus Aureus, Micrococcus Luteus, Bacillus subtilis, gram-negative Escherichia coli, Pseudomonas aeruginosa and Flavobacterium devorans .
|
-
- HY-W777283
-
|
|
Isotope-Labeled Compounds
Apoptosis
Mitochondrial Metabolism
|
Neurological Disease
|
|
Idebenone- 13C,d3 is the deuterium labeled and 13C-labeled Idebenone (HY-N0303). Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM) . Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells . Idebenone quickly crosses the blood-brain barrier.
|
-
- HY-Y1352S
-
-
- HY-151097S
-
-
- HY-Y1220S
-
-
- HY-Y1213S
-
-
- HY-B1449S1
-
-
- HY-154773S
-
-
- HY-B0174AS
-
-
- HY-W768581
-
-
- HY-W088065S
-
-
- HY-B1773AS
-
-
- HY-Y0847S
-
-
- HY-W768213
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
2'-Deoxyguanosine monohydrate- 13C5 is the 13C-labeled 2'-Deoxyguanosine monohydrate (HY-D0185). 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1O2, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer .
|
-
- HY-W747060
-
|
Benzyl Paraben-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Benzyl 4-hydroxybenzoate- 13C6 (Benzyl Paraben- 13C6) is the 13C-labeled Benzyl 4-hydroxybenzoate (HY-W013482). Benzyl 4-hydroxybenzoate is a prominent material. Benzyl 4-hydroxybenzoate can be used as an excipient, such as bacteriostatic agent, preservative. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
|
-
- HY-W251598S
-
|
|
Reference Standards
Bacterial
|
Others
|
|
Bicarbonate- 13C sodium is the 13C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .
|
-
- HY-N0537S2
-
-
- HY-W769017
-
-
- HY-N0537S5
-
-
- HY-121267S
-
-
- HY-W654118
-
-
- HY-122062S
-
-
- HY-N0537S6
-
-
- HY-W035903S
-
-
- HY-N0537S4
-
-
- HY-152072S
-
-
- HY-W777964
-
-
- HY-150679S
-
-
- HY-W770434
-
-
- HY-W010407S
-
-
- HY-141939S
-
-
- HY-I0400S
-
-
- HY-W778142
-
-
- HY-W344468S
-
-
- HY-N2024AS2
-
-
- HY-W747621
-
-
- HY-W780180
-
-
- HY-B1773AS3
-
-
- HY-W585933S
-
-
- HY-106950CS
-
-
- HY-B0451AS5
-
-
- HY-W585934S
-
-
- HY-B0400AS
-
-
- HY-W012584S
-
-
- HY-106950CS1
-
-
- HY-106950CS3
-
-
- HY-Y0827S
-
-
- HY-146994S
-
-
- HY-N2024AS1
-
-
- HY-150194S
-
-
- HY-146995S
-
-
- HY-N0059AS
-
-
- HY-W015824S
-
-
- HY-W028026S
-
-
- HY-146995S1
-
-
- HY-N0667S3
-
|
(-)-Asparagine-13C4 monohydrate; Asn-13C4 monohydrate; Asparamide-13C4 monohydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
|
Inflammation/Immunology
|
|
L-Asparagine- 13C4 monohydrate is the 13C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
|
-
- HY-W750212
-
|
Orange II-13C6; D&C Orange NO. 4-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Acid Orange 7- 13C6 (Orange II- 13C6) is the 13C-labeled Acid orange 7 (HY-N1442). Acid Orange 7 (Orange II; D&C Orange NO. 4) is an azo dye widely used in the textile, food and cosmetic industries. Acid Orange 7 is mainly used as a colorant by combining with fibers and other substances through azo bonds. Acid Orange 7 has a maximum absorption wavelength at 484-485 nm, and the concentration is measured using a UV-visible spectrophotometer. Acid Orange 7 is difficult to degrade and has a certain degree of toxicity. It is often used to study various sewage treatment technologies and photocatalytic degradation reactions, and to evaluate the removal effects of different treatment methods on organic pollutants .
|
-
- HY-N0667S4
-
|
(-)-Asparagine-4-13C monohydrate; Asn-4-13C monohydrate; Asparamide-4-13C monohydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
|
Inflammation/Immunology
|
|
L-Asparagine-4- 13C monohydrate is the 13C-labeled L-Asparagine monohydrate (HY-W017443).L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
|
-
- HY-125818S2
-
|
Cytidine triphosphate-13C,d1 dilithium; 5'-CTP-13C,d1 dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Infection
Cancer
|
|
Cytidine-5'-triphosphate- 13C,d1 (Cytidine triphosphate- 13C,d1 dilithium; 5'-CTP- 13C,d1) dilithium is deuterium and 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
|
-
- HY-W778408
-
|
ICI 47699-13C6; (Z)-Tamoxifen-13C6; trans-Tamoxifen-13C6
|
Isotope-Labeled Compounds
Apoptosis
Autophagy
HSP
Estrogen Receptor/ERR
|
Endocrinology
|
|
Tamoxifen- 13C6 (ICI 47699- 13C6) is the 13C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER transgenic mouse .
|
-
- HY-W777675
-
|
NSC 270912-13C4
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
|
2,5-Deoxyfructosazine- 13C4 (NSC 270912- 13C4) is the 13C-labeled 2,5-Deoxyfructosazine (HY-135078). 2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50=~1.25 mM).
|
-
- HY-W001132S1
-
-
- HY-150915S
-
-
- HY-Y0262BS
-
-
- HY-Y0338S1
-
-
- HY-N0538S2
-
-
- HY-W748319
-
-
- HY-113296S
-
-
- HY-130585S
-
-
- HY-W015824S3
-
-
- HY-Y0546S2
-
-
- HY-B0892S3
-
-
- HY-B1449S4
-
-
- HY-B1449S7
-
-
- HY-W774917S
-
-
- HY-B1449S3
-
-
- HY-N0378S3
-
-
- HY-N0538S
-
-
- HY-W753532
-
-
- HY-N0538S1
-
-
- HY-W016145S
-
-
- HY-Y0589S
-
|
3-Carboxybenzonitrile-13C6; 3-Cyanobenzoic acid-13C6; m-Carboxybenzonitrile-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
m-Cyanobenzoic acid- 13C6 is the 13C labeled m-Cyanobenzoic acid .
|
-
- HY-166934S
-
-
- HY-B0451AS1
-
-
- HY-166919S
-
-
- HY-B1449S2
-
-
- HY-77956S
-
-
- HY-I0400S2
-
-
- HY-W338294S2
-
-
- HY-W338294S
-
-
- HY-B1659AS
-
-
- HY-B1092AS
-
-
- HY-146996S
-
-
- HY-I0400S1
-
-
- HY-141925S
-
-
- HY-116956S3
-
-
- HY-W067028S
-
|
Aminourea-13C,15N2 hydrochloride; Hydrazinecarboxamide-13C,15N2 hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
Semicarbazide- 13C, 15N2 hydrochloride is 15N and 13C labeled Semicarbazide.
|
-
- HY-W099580S
-
-
- HY-W005355S2
-
-
- HY-116956S
-
-
- HY-116956S1
-
-
- HY-I0400S3
-
-
- HY-W145612S
-
-
- HY-N7092AS
-
-
- HY-W585866S
-
-
- HY-W343292S
-
-
- HY-116956S2
-
-
- HY-W142434S
-
-
- HY-W011240S
-
|
Methforylthiazidine-13C,d2; Rontyl-13C,d2
|
Isotope-Labeled Compounds
|
Others
|
|
Hydroflumethiazide- 13C,d2 is the deuterium and 13C labeled Hydroflumethiazide .
|
-
- HY-Y1027S
-
-
- HY-W010696AS
-
-
- HY-B1941S1
-
-
- HY-W016508S1
-
-
- HY-W007318S
-
-
- HY-128748S
-
-
- HY-N8847S
-
-
- HY-Y0383S2
-
-
- HY-150703S
-
-
- HY-W017387S1
-
|
Sodium 4-methyl-2-oxopentanoate-13C2; 2-Ketoisocaproic acid-13C2 sodium salt
|
Isotope-Labeled Compounds
|
Others
|
|
Sodium α-ketoisocaproic acid- 13C2 is the 13C labeled Sodium α-ketoisocaproic acid .
|
-
- HY-139427S
-
-
- HY-150707S
-
-
- HY-W145652S1
-
-
- HY-Y0721S
-
|
m-Bromofluorobenzene-13C6; m-Fluorobromobenzene-13C6; m-Fluorophenyl bromide-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
3-Bromofluorobenzene- 13C6 is the 13C labeled 3-Bromofluorobenzene .
|
-
- HY-W104010S
-
-
- HY-W001138S
-
-
- HY-W779015
-
-
- HY-34428S
-
-
- HY-N0378S1
-
-
- HY-133689AS
-
-
- HY-158034S
-
-
- HY-W777533
-
-
- HY-143848S
-
-
- HY-N0059AS1
-
-
- HY-12651AS
-
|
|
Parasite
|
Others
|
|
Primaquine- 13C,d3 is the deuterium and 13C labeled Primaquine .
|
-
- HY-W013677S
-
-
- HY-10250S
-
-
- HY-141909S
-
-
- HY-13577S
-
-
- HY-143804S
-
-
- HY-W005355S9
-
-
- HY-128748S2
-
-
- HY-W017387S2
-
|
Sodium 4-methyl-2-oxopentanoate-13C6; 2-Ketoisocaproic acid-13C6 sodium salt
|
Isotope-Labeled Compounds
|
Others
|
|
Sodium α-ketoisocaproic acid- 13C6 is the 13C labeled Sodium α-ketoisocaproic acid .
|
-
- HY-W770410
-
-
- HY-17508S
-
-
- HY-W145492S3
-
-
- HY-141928S
-
-
- HY-146994S2
-
-
- HY-Y0931S
-
-
- HY-W145652S
-
-
- HY-143786S
-
-
- HY-W015824S2
-
-
- HY-B0400AS1
-
-
- HY-Y1027S1
-
-
- HY-146994S1
-
-
- HY-113062S
-
-
- HY-N2353S
-
-
- HY-W772341
-
-
- HY-I0459S
-
-
- HY-W013396S
-
-
- HY-I0210S
-
-
- HY-131501S1
-
-
- HY-W140740S
-
-
- HY-W012584S1
-
-
- HY-N6614S1
-
-
- HY-N6714S2
-
-
- HY-128748S1
-
-
- HY-17506S1
-
-
- HY-W767865
-
|
|
Isotope-Labeled Compounds
STING
Endogenous Metabolite
|
Infection
Cardiovascular Disease
Inflammation/Immunology
|
|
Cyclic GMP sodium- 13C5 is the 13C-labeled Cyclic GMP sodium (HY-113469A). Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases .
|
-
- HY-W753593
-
-
- HY-W017443S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
L-Asparagine- 13C4, 15N2 monohydrateis the 13C-labeled and 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
|
-
- HY-W778990
-
|
|
Isotope-Labeled Compounds
Thymidylate Synthase
Endogenous Metabolite
|
Infection
|
|
2-Deoxyuridine-1,2,3,4,5- 13C5 is the 13C-labeled 2'-Deoxyuridine (HY-D0186). 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .
|
-
- HY-W017540S
-
|
|
Isotope-Labeled Compounds
ATP Synthase
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
Cancer
|
|
Cyclocreatine- 13C3 is the 13C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .
|
-
- HY-B1422S
-
|
Aminacrine-13C6
|
Bacterial
HIV
Isotope-Labeled Compounds
|
Infection
|
|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-N0667S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
|
Inflammation/Immunology
|
|
L-Asparagine- 13C4, 15N2,d8 is the 13C-labeled and 15N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
|
-
- HY-W769991
-
|
Lactic acid sodium-13C2
|
Isotope-Labeled Compounds
Bacterial
|
Metabolic Disease
|
|
Lactate sodium (60% in water)- 13C2 (Lactic acid sodium- 13C2) is the 13C-labeled Lactate sodium (60% in water) (HY-B2227B). Lactate (60% in water) (Lactic acid) sodium is the product of glycogenolysis and glycolysis . Lactate sodium (60% in water) is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium (60% in water) can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium (60% in water) is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium (60% in water) is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection . Lactate sodium (60% in water) also has antimicrobial activity, which can be used as a food preservative .
|
-
- HY-77956S1
-
-
- HY-W009204S3
-
-
- HY-77956S2
-
-
- HY-W768398
-
-
- HY-W156840S
-
|
ethanone, 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
OTNE- 13C3 is 13C labeled 2-methoxy-4-propylphenol.
|
-
- HY-128741S
-
-
- HY-W021400S
-
-
- HY-Y0989S3
-
-
- HY-W777148
-
-
- HY-W010392S1
-
-
- HY-W110705S
-
-
- HY-W654058
-
-
- HY-N0378S6
-
-
- HY-W014633S1
-
-
- HY-146986S1
-
-
- HY-W009204S2
-
-
- HY-41121S
-
-
- HY-W012932S
-
-
- HY-N2325S
-
-
- HY-150678S
-
-
- HY-B0141S7
-
-
- HY-W088065S1
-
-
- HY-A0084S1
-
|
Procaine amide-13C2 hydrochloride; SP 100-13C2 hydrochloride
|
Isotope-Labeled Compounds
|
Cancer
|
|
Procainamide- 13C2 hydrochloride is 13C labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.
|
-
- HY-Y1069S3
-
|
(S)-Hydroxybutanedioic acid-13C4; (S)-E 296-13C4; L-Malic acid-13C4
|
Isotope-Labeled Compounds
|
Others
|
|
(S)-Malic acid- 13C4 is the 13C labeled S-Malic acid (HY-Y1069) .
|
-
- HY-152039S1
-
-
- HY-W015198S
-
-
- HY-W338294S1
-
-
- HY-W009362AS
-
-
- HY-N0294S1
-
-
- HY-W012507S1
-
-
- HY-143778S
-
-
- HY-W091039S
-
-
- HY-W769279
-
-
- HY-121259S
-
|
Adriamycinol-13C,d3 TFA; DXR-OL-13C,d3 TFA
|
Endogenous Metabolite
|
Others
|
|
Doxorubicinol- 13C,d3 (TFA) is the deuterium and 13C labeled Doxorubicinol TFA .
|
-
- HY-166923S
-
-
- HY-W654127
-
-
- HY-B0111RS
-
|
Dihydrospirorenone-13C3
|
Isotope-Labeled Compounds
|
Endocrinology
|
|
Drospirenone- 13C3 is 13C labeled Drospirenone. Drospirenone (Dihydrospirorenone) is a synthetic progesterone that is an analog of Spironolactone .
|
-
- HY-141907S
-
-
- HY-B1732S1
-
-
- HY-114364S
-
-
- HY-W020678S
-
-
- HY-W039909S
-
-
- HY-W198678S
-
-
- HY-W001942S2
-
-
- HY-B1659S
-
-
- HY-W017072S
-
-
- HY-Y0781S1
-
|
Acetylformic acid-13C
|
Endogenous Metabolite
|
Others
|
|
Pyruvic acid- 13C is the 13C labeled Pyruvic acid . Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
|
-
- HY-W715199S
-
-
- HY-150628S
-
-
- HY-W768347
-
|
Xylite-13C5
|
Isotope-Labeled Compounds
Bacterial
Autophagy
Endogenous Metabolite
Atg8/LC3
Atg7
|
Cancer
|
|
Xylitol- 13C5 (Xylite- 13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
|
-
- HY-143683S
-
|
1,3-Dimethylxanthine-13C2,d6; Theo-24-13C2,d6
|
Isotope-Labeled Compounds
Phosphodiesterase (PDE)
Interleukin Related
Adenosine Receptor
Apoptosis
HDAC
TNF Receptor
Endogenous Metabolite
|
Cancer
|
|
Theophylline- 13C2,d6 (1,3-Dimethylxanthine- 13C2,d6) is the deuterium labeled and 13C-labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .
|
-
- HY-W765177
-
|
O-Acetyl-L-carnitine hydrochloride-13C3; ALCAR hydrochloride-13C3
|
Isotope-Labeled Compounds
Apoptosis
Caspase
|
Neurological Disease
|
|
Acetyl-L-carnitine hydrochloride- 13C3 (O-Acetyl-L-carnitine hydrochloride- 13C3) is the 13C-labeled Acetyl-L-carnitine hydrochloride (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression .
|
-
- HY-141637S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2-Deoxy-2-fluoro-D-glucose- 13C,d7 is the 13C-labeled and deuterium labeled 2-Deoxy-2-fluoro-D-glucose (HY-141637) . 2-Deoxy-2-fluoro-D-glucose, a radiolabeled glucose analog, is commonly used in medical imaging techniques such as positron emission tomography (PET) scans. FDG has unique chemical properties that allow it to be taken up by cells that actively metabolize glucose, such as cancer cells or inflamed tissue. Once absorbed, FDG emits positrons that can be detected in 2-Deoxy-2-fluoro-D-glucose scans, producing images that highlight areas of high metabolic activity in the body. This makes it a useful tool for diagnosing and monitoring a variety of diseases, including cancer and neurological disorders.
|
-
- HY-128753S4
-
-
- HY-W005355S7
-
-
- HY-166909S
-
-
- HY-128753S3
-
-
- HY-N0086S1
-
|
6-Methyladenosine-sup>13C; N-Methyladenosine-sup>13C
|
Isotope-Labeled Compounds
|
Others
|
|
N6-Methyladenosine- 13C is the 13C labeled isotope of N6-Methyladenosine .
|
-
- HY-128790S
-
-
- HY-141934S
-
-
- HY-Y0442S
-
-
- HY-W746828
-
-
- HY-W654126
-
|
Cytosine β-D-arabinofuranoside--13C3; Cytosine Arabinoside--13C3; Ara-C-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
Cytarabine- 13C3 (Cytosine β-D-arabinofuranoside- 13C3) is 13C labeled Cytarabine .
|
-
- HY-166962S
-
-
- HY-W778144
-
-
- HY-128741S2
-
-
- HY-B2221S4
-
-
- HY-128753S5
-
-
- HY-128741S1
-
-
- HY-16561S2
-
-
- HY-W357090S
-
-
- HY-W777577
-
-
- HY-W005355S8
-
-
- HY-143843S
-
-
- HY-150533S
-
-
- HY-76929S
-
-
- HY-W617979S
-
-
- HY-150706S
-
-
- HY-33212S
-
-
- HY-W097453S
-
-
- HY-W777535
-
-
- HY-W777581
-
-
- HY-W777535S
-
-
- HY-W094748S1
-
-
- HY-15926S
-
|
2-Nitrophenyl β-D-galactopyranoside-13C
|
Isotope-Labeled Compounds
|
Others
|
|
ONPG- 13C is the 13C labeled ONPG. ONPG is a colorimetric and spectrophotometric substrate for detection of β-galactosidase activit .
|
-
- HY-79131S5
-
-
- HY-B1640S
-
-
- HY-146993S
-
-
- HY-W092778S
-
-
- HY-B0389S
-
-
- HY-W102356S1
-
|
Phenethyl alcohol, acetate-13C2
|
Isotope-Labeled Compounds
|
Others
|
|
Phenethyl acetate- 13C2 is 13C labeled Phenethyl acetate (HY-W102356). Phenethyl acetate (Phenethyl alcohol) is a natural product .
|
-
- HY-W778148
-
-
- HY-W585982S
-
-
- HY-W778154
-
-
- HY-N7092S1
-
-
- HY-146992S
-
-
- HY-166915S
-
-
- HY-W010256S
-
-
- HY-W770295
-
-
- HY-W673588S
-
-
- HY-W013058S
-
-
- HY-W010256S3
-
-
- HY-Z2483S
-
-
- HY-Y0781S3
-
|
Acetylformic acid-13C-2 sodium
|
Endogenous Metabolite
|
Others
|
|
Pyruvic acid- 13C-2 (sodium) is the 13C labeled Pyruvic acid . Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
|
-
- HY-Y0504S
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Trimethylammonium chloride- 13C3,d9 is the deuterium and 13C labeled Trimethylammonium chloride . Trimethylammonium chloride is an endogenous metabolite.
|
-
- HY-13553S1
-
-
- HY-W039909S1
-
-
- HY-W779345
-
-
- HY-W327895S
-
-
- HY-76595S1
-
-
- HY-138199S
-
-
- HY-W012980S1
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Isovaleric acid- 13C is the 13C labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.
|
-
- HY-B1732S3
-
-
- HY-G0007S1
-
-
- HY-W010256S1
-
-
- HY-W011873S2
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Palmitoleic acid- 13C16 is the 13C labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.
|
-
- HY-166959S
-
-
- HY-W549233S
-
-
- HY-W012684S
-
|
Ethylenediamine-13C2 dihydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
Ethane-1,2-diamine dihydrochloride- 13C2 is the 13C labeled Ethane-1,2-diamine dihydrochloride .
|
-
- HY-103395S1
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Methylmalonic acid- 13C4 is the 13C labeled Methylmalonic acid . Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer .
|
-
- HY-W013378S4
-
-
- HY-N7092S
-
|
D(-)-Fructose-13C6
|
Endogenous Metabolite
|
Others
|
|
D-Fructose- 13C6 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
|
-
- HY-W012722BS1
-
|
α-Ketoisocaproic acid-13C sodium
|
Isotope-Labeled Compounds
|
Others
|
|
4-Methyl-2-oxopentanoic acid- 13C (sodium) is the 13C labeled 4-Methyl-2-oxopentanoic acid sodium .
|
-
- HY-W749012
-
-
- HY-50719S1
-
-
- HY-128417S1
-
-
- HY-B1659S1
-
-
- HY-W747097
-
-
- HY-W005355S
-
-
- HY-W014632S
-
|
Desacetyl triflusal-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
4-Trifluoromethylsalicylic acid- 13C6 is the 13C labeled 4-Trifluoromethylsalicylic acid . 4-Trifluoromethylsalicylic acid is a platelet aggregation inhibitor .
|
-
- HY-W008507S
-
-
- HY-W654082
-
-
- HY-W585890S
-
-
![Benzo[pqr]tetraphen-3-ol-13C6](//file.medchemexpress.eu/product_pic/hy-w585890s.gif)
- HY-N7092S3
-
-
- HY-B0375S1
-
|
MD-805-13C6 hydrochloride; MCI-9038-13C6 hydrochloride; Argipidine-13C6 hydrochloride
|
Thrombin
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Argatroban- 13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.
|
-
- HY-W012578S1
-
-
- HY-I0960S2
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Uracil- 13C is the 13C labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .
|
-
- HY-Y0418S
-
-
- HY-157386S
-
-
- HY-W013812S
-
|
Linoleic Acid-13C18 ethyl ester; Mandenol-13C18
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
Ethyl linoleate- 13C18 is the 13C labeled Ethyl linoleate. Ethyl linoleate inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators .
|
-
- HY-W703429S
-
-
- HY-Y1117S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Melamine- 13C3 is the 13C labeled Melamine . Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials .
|
-
- HY-W005355S10
-
-
- HY-N0733S
-
-
- HY-166917S
-
-
- HY-W754811
-
-
- HY-B1659S5
-
|
Glycerin-13C3
|
Endogenous Metabolite
|
Cancer
|
|
Glycerol- 13C3 is the 13C labeled Glycerol . Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis .
|
-
- HY-W017049S
-
-
- HY-141919S
-
-
- HY-N3686S
-
-
- HY-150629S
-
-
- HY-N0210S12
-
-
- HY-166918S
-
-
- HY-N0666S
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Aspartic acid- 13C is a 13C labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly .
|
-
- HY-I0960S1
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Uracil- 13C4 is the 13C labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .
|
-
- HY-Y0781S5
-
|
Acetylformic acid-13C,d4
|
Endogenous Metabolite
|
Others
|
|
Pyruvic acid- 13C,d4 is the deuterium and 13C labeled Pyruvic acid . Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
|
-
- HY-B1659S4
-
|
Glycerin-13C2
|
Endogenous Metabolite
|
Cancer
|
|
Glycerol- 13C2 is the 13C labeled Glycerol . Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis .
|
-
- HY-W010489S1
-
-
- HY-B1462S1
-
|
|
Cytochrome P450
|
Inflammation/Immunology
|
|
Chlorzoxazone- 13C is the 13C labeled Chlorzoxazone . Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort .
|
-
- HY-113143AS
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Galactose 1-phosphate- 13C (potassium) is the 13C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug .
|
-
- HY-166903S
-
-
- HY-166900S
-
-
- HY-W097410S1
-
|
N-phenyliodoacetamide-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
2-Iodo-N-phenylacetamide- 13C6 (N-phenyliodoacetamide- 13C6) is the 13C labeled 2-Iodo-N-phenylacetamide.
|
-
- HY-166963S
-
-
- HY-W010388S
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Creatine- 13C is the 13C labeled Creatine . Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain .
|
-
- HY-139312S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
L-Mannitol-1- 13C is the 13C labeled L-Mannitol. L-mannitol is a compound?can be used for ?the compound sweetener synthesis .
|
-
- HY-W718472S
-
-
- HY-W152813S
-
-
- HY-113008S1
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Urocanic acid- 13C3 is the 13C labeled Urocanic acid . Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR) .
|
-
- HY-N7092S7
-
-
- HY-146989S
-
-
- HY-N0105S2
-
-
- HY-N7092S2
-
-
- HY-N0733S3
-
-
- HY-N7092S5
-
-
- HY-N0378S2
-
-
- HY-W007928S
-
-
- HY-150525S
-
-
- HY-23506S
-
-
- HY-W654080
-
|
α,α'-Bis(4-hydroxyphenyl)-1,4-diisopropylbenzene-13C4
|
Isotope-Labeled Compounds
|
Others
|
|
Bisphenol P- 13C4 is 13C labeled α,α'-Bis(4-hydroxyphenyl)-1,4-diisopropylbenzene .
|
-
- HY-154814S
-
-
- HY-N0733S1
-
-
- HY-Y0287AS
-
-
- HY-N7092S4
-
-
- HY-100043S
-
-
- HY-154746S
-
-
- HY-W765043
-
-
- HY-N1420AS
-
|
L-Rhamnose-13C monohydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
Rhamnose- 13C (monohydrate) is the 13C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate c
|
-
- HY-N0210S
-
-
- HY-N7092S6
-
-
- HY-W777457
-
-
- HY-100805S2
-
-
- HY-W015604S
-
-
- HY-113263S1
-
-
- HY-W013378S5
-
-
- HY-B2219S
-
-
- HY-127035S1
-
-
- HY-W748322
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1, 2, 3, 4, 7, 8- Hexachloro-dibenzofuran- 13C12 is 13C labeled 1,2,3,4,7,8-Hexachlorodibenzofuran .
|
-
- HY-166895S
-
-
- HY-Y0418S3
-
-
- HY-W010042S
-
-
- HY-W715361S
-
-
- HY-W104549S
-
-
- HY-166920S
-
-
- HY-Y0418S1
-
-
- HY-B0892S5
-
-
- HY-166933S
-
-
- HY-166893S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,6,7,8-Hexachloronaphthalene- 13C10 is 13C labeled 1,2,3,6,7,8-Hexachloronaphthalene .
|
-
- HY-Y0418S2
-
-
- HY-166897S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,8,9-Hexachlorodibenzofuran- 13C12 is 13C labeled 1,2,3,4,8,9-Hexachlorodibenzofuran .
|
-
- HY-166957S
-
-
- HY-166924S
-
-
- HY-166948S
-
-
- HY-W766368
-
|
C6-Cer-13C2,d2; N-Hexanoylsphingosine-13C2,d2
|
Isotope-Labeled Compounds
Apoptosis
|
Cancer
|
|
C6 Ceramide- 13C2,d2 (C6-Cer- 13C2,d2) is the deuterium labeled and 13C-labeled C6 Ceramide (HY-19542). C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .
|
-
- HY-P1264F
-
|
|
nAChR
|
Neurological Disease
|
|
α-Bungarotoxin, FITC labeledis the FITC labelled α-Bungarotoxin (HY-P1264). α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs) .
|
-
- HY-42682S1
-
|
D-Galactosamine-13C (hydrochloride)
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
D(+)-Galactosamine- 13C (hydrochloride) is the 13C labeled D(+)-Galactosamine hydrochloride. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and
|
-
- HY-W762012S
-
|
OCDD-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
Octachlorodibenzo-p-dioxin- 13C12 is Octachlorodibenzo-p-dioxin- 13 C-labeled octachlorodibenzo-p-dioxin- 13C. Octachlorodibenzo-p-dioxin is a widespread environmental pollutant .
|
-
- HY-113143AS1
-
-
- HY-N0658S6
-
-
- HY-W009444S4
-
-
- HY-150660S
-
-
- HY-N3686S1
-
-
- HY-N0379S5
-
-
- HY-N3686S2
-
-
- HY-W009444S1
-
-
- HY-10353AS1
-
-
- HY-118877
-
|
|
Isotope-Labeled Compounds
|
Infection
|
|
Urea- 13C is the 13C labelled urea. The Urea- 13C breath test ( 13C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection .
|
-
- HY-141637S
-
-
- HY-W653994
-
|
Ethyl parahydroxybenzoate-13C6; Ethyl 4-hydroxybenzoate-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
Ethyl Paraben- 13C6 (Ethyl parahydroxybenzoate- 13C6) is 13C labeled Ethylparaben. Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive .
|
-
- HY-W715357S
-
-
- HY-41417S3
-
|
Caprylic acid-13C
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Octanoic acid- 13C is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-N10004S
-
-
- HY-W715351S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,4,5,7,8-Hexachloro naphthalene- 13C10 is 13C labeled 1,2,4,5,7,8-Hexachloronaphthalene .
|
-
- HY-113075S
-
-
- HY-W009444S2
-
-
- HY-W010184S
-
-
- HY-146990S
-
-
- HY-W009444S3
-
-
- HY-W751145
-
-
- HY-34628S
-
-
- HY-14164S1
-
-
- HY-143784S
-
-
- HY-N1420AS2
-
|
L-Rhamnose-13C-2 monohydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
Rhamnose- 13C-2 (monohydrate) is the 13C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate
|
-
- HY-B1659S2
-
-
- HY-W552229S
-
-
- HY-N0210S3
-
-
- HY-150661S
-
-
- HY-W718518S
-
-
- HY-W243408S
-
-
- HY-B0482S1
-
|
TVX 1322-13C6
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Acemetacin- 13C6 (TVX 1322- 13C6) is 13C labeled Acemetacin. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
|
-
- HY-W767866
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
N-Acetyl-S-(2-carboxyethyl)cysteine- 13C3 (dicyclohexylamine) is 13C labeled N-Acetyl-S-(2-carboxyethyl)cysteine (dicyclohexylamine) .
|
-
- HY-N0210S1
-
-
- HY-W748327
-
-
- HY-W654041
-
-
- HY-166904S
-
-
- HY-W654343
-
-
- HY-23805S
-
-
- HY-N2041S4
-
|
|
Endogenous Metabolite
|
Others
|
|
Myristic acid- 13C3 is the 13C labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
|
-
- HY-106950S1
-
|
Diphosphofructose-13C6 tetrasodium hydrate; Esafosfan-13C6 tetrasodium hydrate; FDP-13C6 tetrasodium hydrate
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Fosfructose- 13C6 (tetrasodium hydrate) is the 13C labeled Fosfructose (HY-106950). Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma .
|
-
- HY-W009597S
-
-
- HY-W718532S
-
-
- HY-W294556S
-
-
- HY-W718525S
-
-
- HY-N0210S4
-
-
- HY-W748303
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1, 2, 3, 7, 8, 9-Hexachloro-dibenzofuran- 13C12 is 13C labeled 1, 2, 3, 7, 8, 9-Hexachloro-dibenzofuran .
|
-
- HY-41417S4
-
|
Caprylic acid-13C4
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Octanoic acid- 13C4 is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-12767S2
-
-
- HY-166927S
-
-
- HY-W770278
-
-
- HY-166961S
-
-
- HY-166949S
-
-
- HY-N0210S2
-
-
- HY-166912S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,5,6,7-Hexachloro-naphthalene- 13C10 is 13C labeled 1,2,3,5,6,7-Hexachloro-naphthalene .
|
-
- HY-W748299
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1, 2, 3, 6, 7, 8-Hexachloro-dibenzofuran- 13C12 is 13C labeled 1, 2, 3, 6, 7, 8-Hexachloro-dibenzofuran .
|
-
- HY-166936S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,5,6,8-Heptachloronaphthalene- 13C10 is 13C labeled 1,2,3,4,5,6,8-Heptachloronaphthalene .
|
-
- HY-B0445S1
-
|
β-DPN-13C5; β-NAD-13C5; β-Nicotinamide Adenine Dinucleotide-13C5
|
Endogenous Metabolite
|
Metabolic Disease
|
|
NAD+- 13C5-1 is the 13C labeled NAD+ . NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
|
-
- HY-W710384S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,5,6,7-Heptachloro naphthalene- 13C10 is 13C labeled 1,2,3,4,5,6,7-Heptachloronaphthalene .
|
-
- HY-W654120
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Creatine- 13C3 is the 13C labeled isotope ofCreatine (HY-W010388) . Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.
|
-
- HY-40354S3
-
-
- HY-W006057AS
-
-
- HY-B0083S1
-
-
- HY-W050145S2
-
|
1,6-Anhydro-β-D-glucopyranose-13C6; 1,6-Anhydro-β-D-glucose-13C6
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Levoglucosan- 13C6 is the 13C labeled Levoglucosan . Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature .
|
-
- HY-B1431S1
-
|
Butyl parahydroxybenzoate-13C6; Butyl 4-hydroxybenzoate-13C6
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
Butylparaben- 13C6 is the 13C labeled Butylparaben . Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.
|
-
- HY-N1446S
-
-
- HY-N0172S
-
|
3,4-Dihydroxycinnamic acid-13C3
|
Bacterial
Fungal
|
Infection
|
|
Caffeic acid- 13C3 is an 13C labeled caffeic acid. Caffeic acid is a phytonutrient belonging to the flavonoids. Caffeic acid and its derivatives, are potential antimicrobial agents, chronic infection induced by microbes such as bacteria, fungi, and viruses .
|
-
- HY-W715184S
-
-
- HY-W748200
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
3-Hydroxypropionic acid- 13C3 sodium is the 13C labeled 3-Hydroxypropionic acid sodium (HY-W095705A). 3-Hydroxypropionic acid sodium, an endogenous metabolite, is a building block in the chemical synthesis .
|
-
- HY-79128S2
-
-
- HY-W779002
-
|
|
Isotope-Labeled Compounds
|
|
|
alpha-D-glucose-13C2-1 is a 13C labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite[1].
|
-
- HY-166670S
-
-
- HY-W010042S2
-
-
- HY-W010042S1
-
-
- HY-B1409S
-
|
ISDN-13C6
|
NO Synthase
|
Cardiovascular Disease
|
|
Isosorbide dinitrate- 13C6 is the 13C labeled Isosorbide dinitrate . Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) .
|
-
- HY-W778057
-
|
Protocatechuic acid ethyl ester-13C3
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
Ethyl 3,4-Dihydroxybenzoate- 13C3 (Protocatechuic acid ethyl ester- 13C3) is the 13C-labeled Ethyl 3,4-dihydroxybenzoate (HY-W016409). Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .
|
-
- HY-N1380S2
-
-
- HY-166940S
-
-
- HY-N7125S
-
|
|
Bacterial
Isotope-Labeled Compounds
|
Others
|
|
Cinnamyl acetate- 13C2 is 13C labeled Cinnamyl acetate (HY-N7125). Cinnamyl acetate has a wide application in the flavor and fragrance industry . Cinnamyl acetate is a new broad spectrum antibacterial agent .
|
-
- HY-B0158S1
-
-
- HY-N0098S3
-
|
|
Endogenous Metabolite
|
Others
|
|
Vanillin- 13C is the 13C labeled Vanillin . Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine .
|
-
- HY-W778140
-
|
|
Isotope-Labeled Compounds
Bacterial
Parasite
|
Infection
|
|
Diethyl phosphate- 13C4 (sodium) is the 13C labeled isotope of Diethyl phosphate- 13C4 (sodium)(HY-101417).Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos .
|
-
- HY-166894S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
3,3′,4,4′,5,5′-Hexabromo diphenyl ether- 13C12 is 13C labeled 3,3′,4,4′,5,5′-Hexabromo diphenyl ether .
|
-
- HY-166899S
-
-
- HY-W354105S
-
-
- HY-W015883S2
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Fumaric acid- 13C2,d2 is the deuterium and 13C labeled Fumaric acid . Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite .
|
-
- HY-W015410S
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Disodium succinate- 13C2 is the 13C labeled Disodium succinate . Disodium succinate is the disodium salt of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism .
|
-
- HY-50667S
-
|
BMS-562247-01-13C,d3
|
Factor Xa
|
Cardiovascular Disease
|
|
Apixaban- 13C,d3 is a deuterium and 13C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively .
|
-
- HY-166942S
-
-
- HY-W749756
-
-
- HY-N0379S7
-
-
- HY-166951S
-
-
- HY-N0394S4
-
|
|
Ferroptosis
Endogenous Metabolite
|
Others
|
|
L-Cystine-3,3'- 13C2 is the 13C labeled L-Cystine . L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes .
|
-
- HY-166935S
-
-
- HY-N6725S
-
-
- HY-76520S
-
-
- HY-34628S2
-
-
- HY-N0379S8
-
|
|
Endogenous Metabolite
|
Others
|
|
D-Mannose- 13C-3 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
|
-
- HY-14832S1
-
-
- HY-W748314
-
-
- HY-N0379S9
-
-
- HY-166889S
-
-
- HY-166926S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2′,3,4,5,5′-Hexachloro diphenyl ether- 13C12 is 13C labeled 2,2′,3,4,5,5′-Hexachloro diphenyl ether .
|
-
- HY-N0305S2
-
|
5-ALA-13C hydrochloride; δ-Aminolevulinic acid-13C hydrochloride; 5-Amino-4-oxopentanoic acid-13C hydrochloride
|
Apoptosis
Autophagy
Mitophagy
Endogenous Metabolite
|
Metabolic Disease
|
|
5-Aminolevulinic acid- 13C (hydrochloride) is the 13C labeled 5-Aminolevulinic acid hydrochloride . 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles .
|
-
- HY-34628S1
-
-
- HY-N0379S6
-
-
- HY-N0379S10
-
-
- HY-41494S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
o-Toluic acid- 13C is the 13C labeled o-Toluic acid . o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
|
-
- HY-W748196S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,6,7-Hexachloro dibenzo-p-dioxin- 13C12 is 13C labeled 1, 2, 3, 4, 6, 7- Hexachlorodibenzo- p- dioxin .
|
-
- HY-166950S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2′,3,4,4′,6-Hexabromo diphenyl ether- 13C12 is 13C labeled 2,2′,3,4,4′,6-Hexabromo diphenyl ether .
|
-
- HY-B1204S3
-
|
Ergamine-13C5
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Histamine- 13C5 is the 13C labeled Histamine (HY-B1204). Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter .
|
-
- HY-N0379S14
-
-
- HY-N1446S2
-
-
- HY-100582S3
-
|
Adonitol-5-13C; Adonite-5-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Ribitol-5- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-17359S1
-
-
- HY-150981S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-O-Isopropylidene-a-D-glucofuranuronic-6- 13C acid, γ-lactone is the 13C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid, γ-lactone .
|
-
- HY-W400722
-
-
- HY-N0098S2
-
|
p-Vanillin-13C6; m-Methoxy-p-hydroxybenzaldehyde-13C6; p-Hydroxy-m-methoxybenzaldehyde-13C6
|
Endogenous Metabolite
|
Others
|
|
Vanillin- 13C6 is the 13C labeled Vanillin . Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine .
|
-
- HY-165686
-
|
N-(Carboxyacetyl)-N-(2,6-dimethylphenyl)-DL-alanine-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
Benalaxyl metabolite M2- 13C3 (N-(Carboxyacetyl)-N-(2,6-dimethylphenyl)-DL-alanine- 13C3) is 13C labeled Benalaxyl metabolite M2 .
|
-
- HY-N6726S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
Fumonisin B3- 13C34 is the 13C labeled Fumonisin B3 (HY-N6726) . Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins .
|
-
- HY-N7092S13
-
-
- HY-W145492S2
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
D-(+)-Talose- 13C is the 13C labeled D-(+)-Talose (HY-W145492) . D-(+)-Talose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N2840S
-
|
Allodulcitol-13C
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Allitol- 13C is the 13C labeled Allitol. Allitol is a rare natural polyol that can be used as a sweetener. Allitol is an important intermediate for the preparation of the agents which against diabetes, cancer, and viral infections, including AIDS
|
-
- HY-100582S1
-
|
Adonitol-2-13C; Adonite-2-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Ribitol-2- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-112537S2
-
-
- HY-W145584S
-
-
- HY-W718588S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,3',5,5'-Hexachlorobiphenyl- 13C12 is 13C labeled 2,2',3,3',5,5'-Hexachloro-1,1'-biphenyl .
|
-
- HY-W006057AS3
-
-
- HY-W006057AS2
-
-
- HY-150980S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2-O-Isopropylidene-β-L-idofuranuronic-6- 13C acid γ-lactone is the 13C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid γ-lactone .
|
-
- HY-N1480S
-
-
- HY-112174S
-
|
UDP-α-D-N-Acetylglucosamine-13C disodium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
UDP-GlcNAc- 13C (disodium) is the 13C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O .
|
-
- HY-100582S2
-
|
Adonitol-3-13C; Adonite-3-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
Ribitol-3- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
|
-
- HY-W777503
-
|
|
Isotope-Labeled Compounds
CaSR
|
Cardiovascular Disease
|
|
Calindol hydrochloride- 13C,d2 is the deuterium and 13C labeled Calindol hydrochloride (HY-122819). Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM .
|
-
- HY-N1446S4
-
-
- HY-N0379S20
-
-
- HY-W718614S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,3,3′,4,5,5′-Hexachloro biphenyl- 13C12 is 13C labeled 2,3,3',4,5,5'-Hexachloro-1,1'-biphenyl .
|
-
- HY-W748343
-
|
2,2',5,5'-Tétrachlorobiphényl-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',5,5'-Tetrachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',5,5'-Tetrachloro-1,1'-biphenyl .
|
-
- HY-166960S
-
-
- HY-166928S
-
-
- HY-B2167S2
-
-
- HY-W748290
-
|
3,4,4',5-Tetrachlorobiphenyl-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
3,4,4',5-Tetrachloro-1,1'-biphenyl- 13C12 is 13C labeled 3,4,4',5-Tetrachloro-1,1'-biphenyl .
|
-
- HY-111592S
-
-
- HY-W748312
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1, 2, 3, 4, 7, 8, 9-Heptachloro-dibenzofuran- 13C12 is 13C labeled 1,2,3,4,7,8,9-Heptachlorodibenzo[b,d]furan .
|
-
- HY-166922S
-
-
- HY-166953S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,6,8-Hexachloro-dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,3,4,6,8-Hexachloro-dibenzo-p-dioxin .
|
-
- HY-W751505
-
-
- HY-134423S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Stearoyl coenzyme A- 13C18 (lithium) is the 13C labeled Stearoyl coenzyme A lithium . Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes .
|
-
- HY-N0230S5
-
|
2-Carboxyethylamine-13C; 3-Aminopropanoic acid-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
β-Alanine- 13C (2-Carboxyethylamine- 13C) is 13C labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
|
-
- HY-166952S
-
-
- HY-B0183S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Ellagic acid- 13C12 is 13 C-labeled Ellagic acid (HY-B0183). Ellagic acid is a natural antioxidant and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC50 of 40 nM and a Ki of 20 nM .
|
-
- HY-B2227BS3
-
|
Lactic acid-13C-1 sodium
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Lactate- 13C-1 sodium (20% in water) is the 13C labeled Lactate (sodium) . Lactate (Lactic acid) sodium (20% in water) is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium (20% in water) functions in a variety of biochemical processes .
|
-
- HY-W715187S
-
-
- HY-W715121S
-
-
- HY-100582S
-
|
Adonitol-1-13C; Adonite-1-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Ribitol-1- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol .
|
-
- HY-Y0366S
-
|
|
Endogenous Metabolite
Bacterial
|
Infection
|
|
Lauric acid- 13C is the 13C labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
|
-
- HY-W100312S
-
|
Toluene, 2-amino-13C6 hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
o-Toluidine-13C6 hydrochloride (Toluene, 2-amino-13C6 hydrochloride) is the 13C labeled isotope of o-Toluidine hydrochloride (HY-W100312) .
|
-
- HY-W778183
-
-
- HY-17016S3
-
|
GS 4104-13C,d3 phosphate
|
Isotope-Labeled Compounds
Influenza Virus
|
Infection
Cancer
|
|
Oseltamivir- 13C,d3 (phosphate) (GS 4104- 13C,d3 (phosphate)) is 13C labeled Oseltamivir (phosphate). Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
|
-
- HY-B0389S19
-
|
Glucose-13C,d; D-(+)-Glucose-13C,d; Dextrose-13C,d
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sign
|
-
- HY-B0158S2
-
-
- HY-N1480S3
-
|
6-Desoxygalactose-13C-3; L-(-)-Fucose-13C-3; L-Galactomethylose-13C-3
|
Isotope-Labeled Compounds
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
|
|
(-)-Fucose- 13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
|
-
- HY-W715198S
-
-
- HY-111095S2
-
|
(R)-2-Hydroxypropionic acid-13C-1; D-Lactic acid-13C-1
|
Endogenous Metabolite
|
Others
|
|
D-(-)-Lactic acid- 13C-1 is the 13C labeled D-(-)-Lactic acid. D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants .
|
-
- HY-N1480S2
-
|
6-Desoxygalactose-13C-2; L-(-)-Fucose-13C-2; L-Galactomethylose-13C-2
|
Isotope-Labeled Compounds
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
|
|
(-)-Fucose- 13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
|
-
- HY-166956S
-
-
- HY-B1374S2
-
-
- HY-156326S
-
-
- HY-150708S
-
-
- HY-113248S1
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Nitro-L-tyrosine- 13C6 is the 13C labeled 3-Nitro-L-tyrosine . 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions .
|
-
- HY-W010452S1
-
-
- HY-W010452S2
-
-
- HY-138622S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
24:0 Lyso PC- 13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .
|
-
- HY-156326S1
-
-
- HY-B0389S25
-
|
Glucose-13C,d1; D-(+)-Glucose-13C,d1; Dextrose-13C,d1
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
|
-
- HY-W721295S
-
-
- HY-W013061S11
-
-
- HY-N1480S1
-
|
6-Desoxygalactose-13C-1; L-(-)-Fucose-13C-1; L-Galactomethylose-13C-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
Parasite
|
Infection
Metabolic Disease
|
|
(-)-Fucose- 13C-1 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
|
-
- HY-Y1093S3
-
|
|
Bacterial
|
Others
|
|
Ethyl acetoacetate- 13C is the 13C labeled Ethyl acetoacetate . Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds . Ethyl acetoacetate is an inhibitor of bacterial biofilm .
|
-
- HY-W010450S3
-
|
|
Endogenous Metabolite
DNA/RNA Synthesis
|
Cancer
|
|
Thymine- 13C is the 13C labeled Thymine . Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM .
|
-
- HY-42680S
-
|
D-(-)-Tagatose-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Tagatose- 13C is the 13C labeled D-Tagatose. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice
|
-
- HY-W793608S
-
-
- HY-W765261
-
-
- HY-W748346
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2′,3,3′,5,5′,6-Heptachloro biphenyl- 13C12 is 13C labeled 2,2',3,3',5,5',6-Heptachloro-1,1'-biphenyl .
|
-
- HY-W715365S
-
-
- HY-128850S1
-
|
N-Acetylmannosamine-13C; ManNAc-13C
|
Bacterial
|
Neurological Disease
|
|
N-Acetyl-D-mannosamine- 13C is the 13C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)
|
-
- HY-W128657S
-
|
2-Hydroxy-3-chloropropionic Acid-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
3-Chloro-2-hydroxypropanoic acid- 13C3 (2-Hydroxy-3-chloropropionic Acid- 13C3) is 13C labeled 3-Chloro-2-hydroxypropanoic acid .
|
-
- HY-166931S
-
-
- HY-W747168
-
-
- HY-139145S
-
|
Trimethylopropane phosphate-13C3
|
GABA Receptor
|
Neurological Disease
|
|
Etbicyphat- 13C3 is the 13C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors .
|
-
- HY-166958S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,6,7,9-Heptachloro dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,3,4,6,7,9-Heptachloro dibenzo-p-dioxin .
|
-
- HY-B0377S1
-
-
- HY-109591S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Oleoyl coenzyme A- 13C18 (lithium) is the 13C labeled Oleoyl Coenzyme A lithium . Oleoyl coenzyme A (Oleoyl-CoA) is a thioester of oleic acid and coenzyme A. Oleoyl coenzyme A has a role as an Escherichia coli metabolite and a mouse metabolite .
|
-
- HY-W017086S2
-
-
![Dibenzo[b,d]furan-13C12](//file.medchemexpress.eu/product_pic/hy-w017086s2.gif)
- HY-W714574S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2′,3,3′,4,4′,5-Heptachloro biphenyl- 13C12 is 13C labeled 2,2',3,3',4,4',5-Heptachloro-1,1'-biphenyl .
|
-
- HY-166925S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2′,3,3′,4′,5,5′-Hexachloro-4-biphenylol- 13C12 is 13C labeled 2′,3,3′,4′,5,5′-Hexachloro-4-biphenylol .
|
-
- HY-Y1055S
-
|
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
|
Guanine- 13C is the 13C labeled Guanine . Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
|
-
- HY-Y1093S1
-
|
|
Bacterial
|
Others
|
|
Ethyl acetoacetate- 13C4 is the 13C labeled Ethyl acetoacetate . Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds . Ethyl acetoacetate is an inhibitor of bacterial biofilm .
|
-
- HY-166901S
-
-
- HY-W777334
-
-
- HY-W242887S2
-
-
- HY-W337886S
-
-
- HY-W738582S
-
-
- HY-Y0264S2
-
|
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
4-Hydroxybenzoic acid- 13C is the 13C labeled 4-Hydroxybenzoic acid . 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL .
|
-
- HY-W018587S
-
-
- HY-W013061S10
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Propane-1,2,3-triyl tripalmitate- 13C is the 13C labeled Propane-1,2,3-triyl tripalmitate . Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
|
-
- HY-B0389S21
-
|
Glucose-13C,d2; D-(+)-Glucose-13C,d2; Dextrose-13C,d2
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Glucose- 13C,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
|
-
- HY-112537S1
-
-
- HY-B0211S1
-
-
- HY-B1459AS
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Dicloxacillin- 13C4 is the 13C labeled Dicloxacillin . Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus .
|
-
- HY-150663S
-
|
1,25-Dihydroxyvitamin D3-13C5
|
Isotope-Labeled Compounds
|
Others
|
|
1α,25-Dihydroxyvitamin D3-(23,24,25,26,27- 13C5) solution is the 13C labeled 1α,25-Dihydroxyvitamin D3 .
|
-
- HY-N1150S2
-
-
- HY-W653853
-
-
- HY-W587423S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2′,3,3′,4,4′,5,5′,6-Nonabromo diphenyl ether- 13C12 is 13C labeled 2,2′,3,3′,4,4′,5,5′,6-Nonabromodiphenyl ether .
|
-
- HY-Y0520S
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Itaconic acid- 13C5 is the 13C labeled Itaconic acid. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors .
|
-
- HY-14781S2
-
-
- HY-W749374
-
-
- HY-W013061S5
-
-
- HY-W013061S1
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Propane-1,2,3-triyl tripalmitate- 13C3 is the 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
|
-
- HY-W748332
-
|
CDE-99-13C12; PCB No 118-13C12; 2,3',4,4',5-Pentachlorobiphenyl-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
PCB118- 13C12 (CDE-99- 13C12; PCB No 118- 13C12; 2,3',4,4',5-Pentachlorobiphenyl- 13C12) is 13C labeled PCB118 .
|
-
- HY-B0389S20
-
|
Glucose-13C,d-1; D-(+)-Glucose-13C,d-1; Dextrose-13C,d-1
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Glucose- 13C,d-1 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
|
-
- HY-W012864S
-
-
- HY-22306S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
β-D-Glucose pentaacetate- 13C6 is the 13C labeled β-D-Glucose pentaacetate[1]. β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is used in biochemical reaction.
|
-
- HY-N0379S18
-
-
- HY-N6692S
-
|
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Diacetoxyscirpenol- 13C19 is 13C labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals .
|
-
- HY-166914S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,3',4,5,5'-Heptachloro-4'-methoxybiphenyl- 13C12 is 13C labeled 2,2',3,3',4,5,5'-Heptachloro-4'-methoxybiphenyl .
|
-
- HY-104026CS
-
-
- HY-15409S1
-
|
BI 10773-13C6
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Empagliflozin- 13C6 (BI 10773- 13C6) is 13C labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2 .
|
-
- HY-143679S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate-13C6 is the 13C labeled isotope of 4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate .
|
-
- HY-W768338
-
|
D-(+)-Saccharose-13C
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Sucrose- 13C is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
|
-
- HY-A0161S
-
|
Clofedanol-13C6; Calmotusin-13C6; NSC 113595-13C6
|
Isotope-Labeled Compounds
|
Infection
|
|
Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
|
-
- HY-166896S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,3,3',4',5,5'-Hexachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,3,3',4',5,5'-Hexachloro-1,1'-biphenyl .
|
-
- HY-W748345
-
|
2,3',4,4',5,5'-Hexachlorobiphenyl-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
2,3',4,4',5,5'-Hexachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,3',4,4',5,5'-Hexachloro-1,1'-biphenyl .
|
-
- HY-B1328S3
-
|
Pyridoxol-13C4
|
Isotope-Labeled Compounds
|
Neurological Disease
Cancer
|
|
Pyridoxine- 13C4 (Pyridoxol- 13C4) is 13C labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
|
-
- HY-W008351S
-
|
|
Antibiotic
Isotope-Labeled Compounds
|
Cancer
|
|
L-Ribose- 13C is the 13C labeled L-Ribose. L-Ribose, a non-naturally occurring pentose, is an ideal starting material for use in synthesizing L-nucleosides analogues. Many anticancer and antiviral agents are synthesized based on a backbone of L-Ribose and i
|
-
- HY-42680S1
-
|
D-(-)-Tagatose-13C-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Tagatose- 13C-1 is the 13C labeled D-Tagatose. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit jui
|
-
- HY-W018772S1
-
-
- HY-W242887S3
-
-
- HY-Y0479AS
-
-
- HY-166945S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,3,3′,4,5,5′-Hexachloro-4′-methoxy biphenyl- 13C12 is 13C labeled 2,3,3′,4,5,5′-Hexachloro-4′-methoxy biphenyl .
|
-
- HY-W708160S
-
-
- HY-W517076S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,6,7,8-Hexachloro dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,3,6,7,8-Hexachlorodibenzo[b,e][1,4]dioxine .
|
-
- HY-W750238
-
|
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Scoparone- 13C2,d6 is the deuterium and 13C labeled Scoparone (HY-N0228). Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .
|
-
- HY-141857S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-2,4,5- 13C3 is the deuterium and 13C labeled 5-(4-Hydroxyphenyl)-5-phenyl-hydantoin .
|
-
- HY-N1482S
-
|
|
Parasite
|
Inflammation/Immunology
|
|
Methyl palmitate- 13C16 is the 13C labeled Methyl palmitate. Methyl palmitate, an acaricidal compound occurring in green walnut husks, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects .
|
-
- HY-N1150S5
-
-
- HY-17436S3
-
|
|
Calcium Channel
|
Cardiovascular Disease
|
|
(R)-Clevidipine- 13C,d3 is the deuterium and 13C labeled Clevidipine . Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension .
|
-
- HY-10158S1
-
-
- HY-40354S2
-
-
- HY-B1278AS
-
|
Vitamin E acetate-13C4,d6
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
DL-α-Tocopherol acetate- 13C4,d6 is the deuterium and 13C labeled DL-α-Tocopherol acetate . DL-α-Tocopherol acetate is a vitamin E derivative which is often included in the formulations of enteral nutrition .
|
-
- HY-N0470S8
-
|
|
Endogenous Metabolite
Virus Protease
|
Infection
|
|
L-Lysine- 13C6 hydrochloride is the 13C labeled L-Lysine hydrochloride . L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health .
|
-
- HY-13613S
-
|
GG 745-13C6; GI 198745-13C6
|
Apoptosis
5 alpha Reductase
|
Cancer
|
|
Dutasteride- 13C6 is the 13C labeled Dutasteride . Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
|
-
- HY-B0221S
-
|
|
Isotope-Labeled Compounds
Antibiotic
Fungal
Parasite
Bacterial
|
Cancer
|
|
Amphotericin B- 13C6 is 13C labeled Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
|
-
- HY-21268S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Methyl linolenate- 13C18 is the 13C labeled Methyl linolenate[1]. Methyl linolenate is a polyunsaturated fattly acid (PUFA). It is used in studies on the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids[2][3]. The IC50 is 60 uM[4].
|
-
- HY-10984S4
-
-
- HY-N0420S2
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Succinic acid- 13C4 is the 13C labeled Succinic acid . Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries .
|
-
- HY-19657S
-
-
- HY-10268S2
-
|
PRT054021-13C6
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Betrixaban- 13C6 (PRT054021- 13C6) is 13C labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect .
|
-
- HY-B0400S1
-
|
Sorbitol-13C; D-Glucitol-13C
|
Endogenous Metabolite
|
Others
|
|
D-Sorbitol- 13C is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary s
|
-
- HY-A0132S1
-
-
- HY-128850S2
-
|
N-Acetylmannosamine-13C-1; ManNAc-13C-1
|
Isotope-Labeled Compounds
Bacterial
|
Neurological Disease
|
|
N-Acetyl-D-mannosamine- 13C-1 is the 13C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)
|
-
- HY-N6685S1
-
|
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
3-Acetyldeoxynivalenol- 13C17 is the 13C labeled 3-Acetyldeoxynivalenol (HY-N6685) . 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .
|
-
- HY-128793S
-
|
(E)-Stilbene-13C2
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
|
|
trans-Stilbene- 13C2 ((E)-Stilbene- 13C2) is the 13C labeled trans-Stilbene (HY-128793) . trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens .
|
-
- HY-W015913S3
-
|
|
Endogenous Metabolite
Reactive Oxygen Species (ROS)
|
Metabolic Disease
|
|
Sodium 2-oxopropanoate- 13C is the 13C labeled Sodium 2-oxopropanoate . Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .
|
-
- HY-B0389S22
-
|
Glucose-13C2,d2; D-(+)-Glucose-13C2,d2; Dextrose-13C2,d2
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Glucose- 13C2,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
|
-
- HY-D0186S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Infection
|
|
2'-Deoxyuridine-1′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
|
-
- HY-B0612AS
-
|
|
Calcium Channel
|
Cardiovascular Disease
|
|
Lercanidipine- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Lercanidipine hydrochloride . Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect .
|
-
- HY-W041171S
-
|
|
Endogenous Metabolite
|
Others
|
|
3-Chloro-L-tyrosine- 13C6 is the 13C labeled 3-Chloro-L-tyrosine . 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima .
|
-
- HY-166929S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2′,3,4′,5,5′,6-Heptachloro-4-methoxy biphenyl- 13C12 is 13C labeled 2,2′,3,4′,5,5′,6-Heptachloro-4-methoxy biphenyl .
|
-
- HY-D0186S3
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Infection
|
|
2'-Deoxyuridine-5′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
|
-
- HY-D0186S2
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Infection
|
|
2'-Deoxyuridine-3′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
|
-
- HY-N1150S4
-
-
- HY-B1779S5
-
|
D-(+)-Saccharose-13C6
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Sucrose- 13C6 is the 13C labeled Sucrose . Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al .
|
-
- HY-W013061S4
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Propane-1,2,3-triyl tripalmitate- 13C3-1 is the 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
|
-
- HY-W748321
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,4',5,6,6'-heptachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,4',5,6,6'-Heptachloro-1,1'-biphenyl .
|
-
- HY-13966S2
-
|
2-DG-13C; 2-Deoxy-D-arabino-hexose-13C; D-Arabino-2-deoxyhexose-13C
|
Isotope-Labeled Compounds
Apoptosis
Hexokinase
HSV
|
Cancer
|
|
2-Deoxy-D-glucose- 13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .
|
-
- HY-W716411S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,5-Pentabromo-6-(2,3-dibromophenoxy)benzene- 13C12 is 13C labeled 1,2,3,4,5-Pentabromo-6-(2,3-dibromophenoxy)benzene .
|
-
- HY-D0186S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Infection
|
|
2'-Deoxyuridine-2′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
|
-
- HY-W748284
-
|
2,4,4'-Trichlorobiphenyl-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
2,4,4'-Trichloro-1,1'-biphenyl- 13C12 (2,4,4'-Trichlorobiphenyl- 13C12) is 13C labeled 2,4,4'-Trichloro-1,1'-biphenyl .
|
-
- HY-W006057AS17
-
|
|
Endogenous Metabolite
|
Others
|
|
3-Methyl-2-oxobutanoic acid- 13C2 is the 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
|
-
- HY-N0229S19
-
-
- HY-165124S
-
|
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
1,2,3,4,6,7,8-Heptachlorodibenz- 13C12 is 13C labeled 1,2,3,4,6,7,8-Heptachlorodibenz. 1,2,3,4,6,7,8-Heptachlorodibenz is a biochemical reagent.
|
-
- HY-B1337S5
-
|
|
nAChR
Endogenous Metabolite
|
Cancer
|
|
Choline- 13C2 (chloride) is the 13C labeled Choline chloride . Choline chloride is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders .
|
-
- HY-W006057AS16
-
|
|
Endogenous Metabolite
|
Others
|
|
Sodium 3-methyl-2-oxobutanoate- 13C5 is the 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
|
-
- HY-W715180S
-
-
- HY-N1150S3
-
-
- HY-W012864S1
-
-
- HY-W012864S2
-
-
- HY-10984S3
-
-
- HY-A0132S3
-
-
- HY-W018772S4
-
-
- HY-B0400S2
-
|
Sorbitol-13C-1; D-Glucitol-13C-1
|
Endogenous Metabolite
|
Others
|
|
D-Sorbitol- 13C-1 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-W753141
-
|
4,4'-DDE-13C12; p,p'-Dichlorodiphenyldichloroethylene-13C12
|
Isotope-Labeled Compounds
Androgen Receptor
Drug Metabolite
|
Endocrinology
|
|
p,p'-DDE- 13C12 is 13C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM .
|
-
- HY-112251S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle .
|
-
- HY-W015307S
-
|
|
Biochemical Assay Reagents
Isotope-Labeled Compounds
|
Others
|
|
4-Ethyloctanoic acid- 13C2 is 13C labeled 4-Ethyloctanoic acid (HY-W015307). 4-Ethyloctanoic acid is a natural compound first isolated from Saussurea lappa Clarke, widely used as a safe flavoring compound and acts as food additive .
|
-
- HY-17530S
-
-
- HY-W018772S2
-
-
- HY-B0554S1
-
|
Norethisterone-13C2
|
Isotope-Labeled Compounds
Progesterone Receptor
Bacterial
|
Endocrinology
|
|
Norethindrone- 13C2 (Norethisterone- 13C2) is the 13C labeled Norethindrone (HY-B0554) . Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea .
|
-
- HY-N6683S1
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
15-Acetyl-deoxynivalenol- 13C17 is the 13C labeled 15-Acetyl-deoxynivalenol (HY-N6683) . 15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .
|
-
- HY-104026BS
-
-
- HY-W015913S4
-
|
|
Endogenous Metabolite
Reactive Oxygen Species (ROS)
|
Metabolic Disease
|
|
2-Oxopropanoate- 13C5 (sodium) is the 13C labeled Sodium 2-oxopropanoate . Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .
|
-
- HY-166908S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,3',4,4',5,6,6'-Nonabromo diphenyl ether- 13C12 is 13C labeled 1,2,3,4,5-Pentabromo-6-(2,3,4,6-tetrabromophenoxy)benzene .
|
-
- HY-B0400S3
-
|
Sorbitol-13C-2; D-Glucitol-13C-2
|
Endogenous Metabolite
|
Others
|
|
D-Sorbitol- 13C-2 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
|
-
- HY-W018772S5
-
-
- HY-W018772S3
-
-
- HY-N0097S4
-
|
DL-Guanosine-13C10; Vernine-13C10
|
Isotope-Labeled Compounds
Endogenous Metabolite
HSV
|
Infection
|
|
Guanosine- 13C10 is the 13C labeled Guanosine (HY-N0097). Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .
|
-
- HY-B1449S10
-
|
β-Uridine-13C5
|
Isotope-Labeled Compounds
|
Cancer
|
|
Uridine- 13C5 (β-Uridine- 13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.
|
-
- HY-W748282
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,3,3',4,4',5,5',6-Octachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,3,3',4,4',5,5',6-Octachloro-1,1'-biphenyl .
|
-
- HY-W748349
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,3',4,4',5,5'-Octachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,3',4,4',5,5'-Octachloro-1,1'-biphenyl .
|
-
- HY-W768340
-
|
D-(+)-Saccharose-13C6-1
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
|
-
- HY-W778225
-
|
|
Isotope-Labeled Compounds
|
Infection
|
|
Vanillic acid- 13C6 is the 13C labeled isotope of Vanillic acid- 13C6(HY-N0708 ).Vanillic acid is a flavoring agent found in edible plants and fruits, and in the root of angelica. Vanillic acid inhibits NF-κB activation. It has anti-inflammatory and antimicrobial activities.
|
-
- HY-N0420S4
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Succinic acid- 13C2 is the 13C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].
|
-
- HY-Y0836S
-
|
1,4-Diethyl butanedioate-1,2,3,4-13C4
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Diethyl succinate- 13C4 is the 13C labeled Diethyl succinate . Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring .
|
-
- HY-W779534
-
-
- HY-W751832
-
|
5,6-Diaminouracil hydrochloride-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
5,6-Diaminopyrimidine-2,4-diol hydrochloride- 13C3 (5,6-Diaminouracil hydrochloride- 13C3) is the 13C-labeled5,6-Diaminopyrimidine-2,4-diol (HY-W002107).
|
-
- HY-A0132S2
-
-
- HY-N0420S3
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Butanedioic acid- 13C2 is the 13C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].
|
-
- HY-15029S2
-
|
|
COX
|
Cancer
|
|
(±)-Naproxen- 13C,d3 is the deuterium and 13C labeled (±)-Naproxen . (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively.
|
-
- HY-W748204
-
|
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
1,2,3,7,8-Pentachloro dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,3,7,8-Pentachlorodibenzo-p-dioxin. 1,2,3,7,8-Pentachlorodibenzo-p-dioxin is a biochemical reagent .
|
-
- HY-B0400S16
-
|
Sorbitol-13C6; D-Glucitol-13C6
|
Bacterial
Endogenous Metabolite
|
Others
|
|
D-Sorbitol- 13C6 is the 13C labeled D-Sorbitol . D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement .
|
-
- HY-W748355
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,3',5,5',6,6'-Octachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,3',5,5',6,6'-Octachloro-1,1'-biphenyl .
|
-
- HY-A0132S5
-
-
- HY-W654136
-
|
Deoxycytidine-13C; Cytosine deoxyriboside-13C; Deoxyribose cytidine-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
2'-Deoxycytidine-2'- 13C is 13C labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, can inhibit biological effects of Bromodeoxyuridine (Brdu). 2'-Deoxycytidine is essential for the synthesis of nucleic acids, that can be used for the research of cancer .
|
-
- HY-14608S10
-
|
|
Apoptosis
iGluR
Ferroptosis
Endogenous Metabolite
|
Neurological Disease
|
|
L-Glutamic acid- 13C2 is the 13C labeled L-Glutamic acid . L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals .
|
-
- HY-W777456
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Phenanthrene- 13C6 is the 13C labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
|
-
- HY-B0228S5
-
-
- HY-B0166S2
-
-
- HY-18341S2
-
|
|
Thyroid Hormone Receptor
Endogenous Metabolite
|
Endocrinology
|
|
L-Thyroxine- 13C6 is the 13C labeled L-Thyroxine . L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
|
-
- HY-W007928S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1-O-Acetyl 2,3,5-tri-O-benzoyl-beta-D-ribofuranoside- 13C-1 is the 13C labeled 1-O-Acetyl-2,3,5-Tri-O-benzoyl-beta-D-Ribofuranose .
|
-
- HY-B0476S1
-
|
|
COX
|
Inflammation/Immunology
|
|
Phenacetin- 13C is the 13C labeled Phenacetin . Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .
|
-
- HY-15027S2
-
|
Mesalamine-13C6; 5-ASA-13C6; Mesalazine-13C6
|
PPAR
PAK
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
|
|
5-Aminosalicylic acid- 13C6 is the 13C labeled 5-Aminosalicylic Acid . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
|
-
- HY-B0166S5
-
-
- HY-13966S4
-
|
2-DG-13C-1; 2-Deoxy-D-arabino-hexose-13C-1; D-Arabino-2-deoxyhexose-13C-1
|
Isotope-Labeled Compounds
Apoptosis
Hexokinase
HSV
|
Cancer
|
|
2-Deoxy-D-glucose- 13C-1 is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .
|
-
- HY-B0389S10
-
|
Glucose-13C; D-(+)-Glucose-13C; Dextrose-13C
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
|
-
- HY-N0305S3
-
|
5-ALA-13C-1 hydrochloride; δ-Aminolevulinic acid-13C-1 hydrochloride; 5-Amino-4-oxopentanoic acid-13C-1 hydrochloride
|
Apoptosis
Autophagy
Mitophagy
Endogenous Metabolite
|
Metabolic Disease
|
|
5-Aminolevulinic acid- 13C-1 (5-ALA- 13C-1) hydrochloride is the 13C labeled 5-Aminolevulinic acid hydrochloride . 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles .
|
-
- HY-B1654S
-
|
FAD-13C5 ammonium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Flavin adenine dinucleotide- 13C5 (FAD- 13C5) ammonium is 13C labeled Flavin adenine dinucleotide (HY-B1654). Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
|
-
- HY-B0271S1
-
|
Pyrazinecarboxamide-13C,15N; Pyrazinoic acid amide-13C,15N
|
Autophagy
Antibiotic
Bacterial
Isotope-Labeled Compounds
|
Infection
|
|
Pyrazinamide- 13C, 15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
|
-
- HY-W777702
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,4',5,5',6-Heptachloro-4-biphenylol- 13C12 is 13C labeled 2,2',3,4',5,5',6-Heptachloro-[1,1'-biphenyl]-4-ol .
|
-
- HY-N0610AS2
-
|
3-Phenylacrylic acid-13C3; β-Phenylacrylic acid-13C3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
Cinnamic acid- 13C3 (3-Phenylacrylic acid- 13C3) is the 13C labeled Cinnamic acid (HY-N0610A). Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells .
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-
- HY-W016433S
-
|
|
DNA/RNA Synthesis
|
Others
|
|
2-Aminofluorene- 13C is the 13C labeled 2-Aminofluorene . 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .
|
-
- HY-B0166S4
-
-
- HY-B0190S1
-
|
|
Ser/Thr Protease
Apoptosis
SARS-CoV
|
Cardiovascular Disease
|
|
Nafamostat formate salt- 13C6 is the 13C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .
|
-
- HY-I0301S
-
-
- HY-B0166S3
-
-
- HY-W715311S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,3',4',5,5'-Heptachloro-4-biphenylol- 13C12 is 13C labeled 2,2',3,3',4',5,5'-Heptachloro-[1,1'-biphenyl]-4-ol .
|
-
- HY-18342S1
-
|
MK-647-13C6
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
|
Diflunisal- 13C6 (MK-647- 13C6) is 13C labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
|
-
- HY-W012998S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,3-Pentanedione- 13C2 is 13C labeled Furaneol (HY-N7093). Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines .
|
-
- HY-B0228S3
-
-
- HY-A0090S
-
|
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Others
|
|
Nitrofurantoin- 13C3 is the 13C labeled Nitrofurantoin (HY-A0090) . Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .
|
-
- HY-126373S1
-
|
SN-38G-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
SN-38 glucuronide- 13C6 is the 13C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
|
-
- HY-150012S1
-
-
- HY-W748320
-
|
2,2',3,3',4,4',5,5'-Octachlorobiphenyl-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,3',4,5,5',6,6'-Nonachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,3',4,5,5',6,6'-Nonachloro-1,1'-biphenyl .
|
-
- HY-Y0264S
-
|
|
Isotope-Labeled Compounds
|
Infection
|
|
4-Hydroxybenzoic acid- 13C6 is the 13C labeled isotope of 4-Hydroxybenzoic acid- 13C6.4-Hydroxybenzoic acid is a phenolic derivative of benzoic acid, which can inhibit most Gram-positive bacteria and some Gram-negative bacteria with an IC50 value of 160 μg/mL.
|
-
- HY-B0947S1
-
|
|
P-glycoprotein
Bacterial
|
Infection
|
|
Sulfanitran- 13C6 is the 13C labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG).
|
-
- HY-166939S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
3,4,5,6-Tetrabromo[1,1′-biphenyl]-2,2′-diol- 13C12 is 13C labeled 3,4,5,6-Tetrabromo[1,1′-biphenyl]-2,2′-diol .
|
-
![3,4,5,6-Tetrabromo[1,1′-biphenyl]-2,2′-diol-13C12](//file.medchemexpress.eu/product_pic/hy-166939s.gif)
- HY-B0228S2
-
-
- HY-17410S2
-
-
- HY-W748350
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',3,3',4,4',5,5',6-Nonachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,3',4,4',5,5',6-Nonachloro-1,1'-biphenyl .
|
-
- HY-W011297S3
-
|
Arachidonic acid methyl ester-13C5
|
Isotope-Labeled Compounds
Others
|
Metabolic Disease
|
|
Methyl arachidonate- 13C5 (Arachidonic acid methyl ester- 13C5) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
|
-
- HY-W006057AS14
-
|
|
Endogenous Metabolite
|
Others
|
|
Sodium 3-methyl-2-oxobutanoate- 13C,d4 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
|
-
- HY-W762019S
-
|
1,2,3,4,7,8-HxCDD-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,7,8-Hexachloro dibenzo-p-dioxin- 13C12 (1,2,3,4,7,8-HxCDD- 13C12) is 13C labeled 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin .
|
-
- HY-10163S2
-
|
BIBR 953-13C6; BIBR 953ZW-13C6
|
Thrombin
|
Cardiovascular Disease
|
|
Dabigatran- 13C6 is the 13C labeled Dabigatran . Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM) .
|
-
- HY-B0228S4
-
-
- HY-N0092S1
-
-
- HY-W015851S
-
|
3-Hydroxybutyric acid-13C sodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutanoic acid-13C- 13C (sodium) is the 13C labeled 3-Hydroxybutanoic acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .
|
-
- HY-B0389S11
-
|
Glucose-13C-1; D-(+)-Glucose-13C-1; Dextrose-13C-1
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
|
-
- HY-W008807S
-
|
Phosphoenolpyruvate (potassium)-13C2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Phosphoenolpyruvic acid (potassium)- 13C2 is the 13C labeled Phosphoenolpyruvic acid potassium (HY-W008807) . Phosphoenolpyruvic acid (Phosphoenolpyruvate) potassium is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid potassium is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid potassium also exhibits cytoprotective and anti-oxidative properties .
|
-
- HY-W751082
-
-
- HY-B0389S17
-
|
Glucose-13C-5; D-(+)-Glucose-13C-5; Dextrose-13C-5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C-5 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
|
-
- HY-B0389S16
-
|
Glucose-13C-4; D-(+)-Glucose-13C-4; Dextrose-13C-4
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
|
-
- HY-B0389S13
-
|
Glucose-13C-3; D-(+)-Glucose-13C-3; Dextrose-13C-3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C-3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
|
-
- HY-W748291
-
|
2,3,4,4',5-Pentachlorobiphenyl-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
2,3,4,4',5-Pentachloro-1,1'-biphenyl- 13C12 (2,3,4,4',5-Pentachlorobiphenyl- 13C12) is 13C labeled 2,3,4,4',5-Pentachloro-1,1'-biphenyl .
|
-
- HY-W777166
-
-
- HY-B0389S14
-
|
Glucose-13C2; D-(+)-Glucose-13C2; Dextrose-13C2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-N6723S
-
|
|
Isotope-Labeled Compounds
|
Infection
|
|
Fumonisin B2- 13C34 is the 13C labeled Fumonisin B2 (HY-N6723) . Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .
|
-
- HY-Y1636S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Fmoc-Arg(Pbf)-OH- 13C6 is the 13C labeled Fmoc-Arg(Pbf)-OH . Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
|
-
- HY-79369S1
-
|
|
ADC Linker
|
Cancer
|
|
Succinic anhydride- 13C2 is the 13C labeled Succinic anhydride . Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide .
|
-
- HY-W006057AS15
-
|
|
Endogenous Metabolite
|
Others
|
|
Sodium 3-methyl-2-oxobutanoate- 13C,d4-1 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
|
-
- HY-W779542
-
-
- HY-N0304S2
-
|
|
Dopamine Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
L-DOPA- 13C is the 13C labeled L-DOPA . L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
|
-
- HY-100807S1
-
|
|
Isotope-Labeled Compounds
iGluR
Endogenous Metabolite
|
Others
|
|
Quinolinic acid- 13C7 is the 13C labeled Quinolinic acid (HY-100807) . Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction .
|
-
- HY-14283S
-
|
NND 502-13C7
|
Isotope-Labeled Compounds
|
Infection
|
|
Luliconazole- 13C7 (NND 502- 13C7) is 13C labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .
|
-
- HY-W585819S
-
|
3-MPCD dipalmitate-13C3; 3-CPD dipalmitate-13C3
|
Isotope-Labeled Compounds
Others
|
Others
|
|
3-Chloropropane-1,2-diol dipalmitate- 13C3 is 13C labeled 3-Chloropropane-1,2-diol dipalmitate. 3-Chloropropane-1,2-diol dipalmitate is a free fatty acid consisting mainly of diesters .
|
-
- HY-W269693S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
5-(4-Hydroxyphenyl)-5-phenylimidazolidine-2,4-dione- 13C3,d5 is the deuterium and 13C labeled 5-(4-Hydroxyphenyl)-5-phenylimidazolidine-2,4-dione .
|
-
- HY-W777978
-
|
α-Bromo-3'-methoxyacetophenone-13C,d3
|
Isotope-Labeled Compounds
|
Others
|
|
2-Bromo-3'-methoxyacetophenone- 13C,d3 (α-Bromo-3'-methoxyacetophenone- 13C,d3) is the deuterium and 13C labeled 2-Bromo-3'-methoxyacetophenone (HY-W004800).
|
-
- HY-W243018S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2:5,6-Di-O-isopropylidene-a-D-glucofuranose-1,2,3,4,5,6- 13C6 is the 13C labeled 1,2:5,6-Di-O-isopropylidene-a-D-glucofuranose-1,2,3,4,5,6 .
|
-
- HY-17430S2
-
-
- HY-W011297S2
-
|
Arachidonic acid methyl ester-13C4
|
Isotope-Labeled Compounds
Others
|
Metabolic Disease
|
|
Methyl arachidonate- 13C4 (Arachidonic acid methyl ester- 13C4) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
|
-
- HY-W009362S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
DL-Isocitric acid- 13C4 (trisodium salt) is a 13C labeled DL-Isocitric acid (trisodium salt) (HY-W009362). DL-Isocitric acid trisodium salt is an endogenous metabolite. DL-Isocitric acid trisodium salt is a substrate in the citric acid cycle. DL-Isocitric acid trisodium salt can be used as a marker for determining the composition of isocitrates in fruit products, including fruit juices.
|
-
- HY-B0411S2
-
|
R33812-13C6
|
Isotope-Labeled Compounds
Dopamine Receptor
|
Neurological Disease
|
|
Domperidone- 13C6 (R33812- 13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine .
|
-
- HY-10392S
-
|
PNU-100480-13C4; U-100480-13C4; PF-02341272-13C4
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Sutezolid- 13C4 (PNU-100480- 13C4) is 13C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
|
-
- HY-101277S1
-
|
PG-1016548-13C6; AKB-6548-13C6
|
Isotope-Labeled Compounds
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
|
Vadadustat- 13C6 (PG-1016548- 13C6) is 13C labeled Vadadustat. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .
|
-
- HY-B0389S15
-
|
Glucose-13C2-4; D-(+)-Glucose-13C2-4; Dextrose-13C2-4
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C2-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
|
-
- HY-150918S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl- 13C5 is the 13C labeled 3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl .
|
-
- HY-N0001S2
-
-
- HY-76082S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Inflammation/Immunology
|
|
L-Pyroglutamic acid- 13C5 is the 13C labeled L-Pyroglutamic acid (HY-76082) . L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid can be used as a biomarker for systemic lupus erythematosus (SLE) .
|
-
- HY-B0149S2
-
|
Cyclocapron-13C6
|
Isotope-Labeled Compounds
MMP
Mitophagy
IGF-1R
AMPK
|
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Tranexamic acid- 13C6 (Cyclocapron- 13C6) is 13C labeled Tranexamic acid. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .
|
-
- HY-W006057AS13
-
|
|
Endogenous Metabolite
|
Others
|
|
Sodium 3-methyl-2-oxobutanoate- 13C4,d3 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
|
-
- HY-N0001S
-
-
- HY-12008S1
-
|
CP-358774-13C6 hydrochloride; NSC 718781-13C6 hydrochloride; OSI-774-13C6 hydrochloride
|
EGFR
Autophagy
|
Cancer
|
|
Erlotinib- 13C6 hydrochloride is the 13C labeled Erlotinib Hydrochloride . Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM . Erlotinib- 13C6 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-13966S3
-
|
2-DG-13C6; 2-Deoxy-D-arabino-hexose-13C6; D-Arabino-2-deoxyhexose-13C6
|
Isotope-Labeled Compounds
Apoptosis
Hexokinase
HSV
|
Cancer
|
|
2-Deoxy-D-glucose- 13C6 (2-DG- 13C6) is 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .
|
-
- HY-W778290
-
|
5-Chloro-o-anisic acid (COOH=1)-13C,d3; 5-Chloro-2-methoxybenzoic acid-13C,d3
|
Isotope-Labeled Compounds
|
Others
|
|
5-Chloro-2-methoxy-benzoic Acid- 13C,d3 (5-Chloro-o-anisic acid (COOH=1)- 13C,d3) is the deuterium and 13C labeled 5-Chloro-2-methoxybenzoic acid (HY-W016163).
|
-
- HY-B0389S18
-
|
Glucose-13C3-1; D-(+)-Glucose-13C3-1; Dextrose-13C3-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
|
-
- HY-109590S3
-
|
Immunocytophyt-13C4
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
|
|
Arachidonic acid- 13C4 (Immunocytophyt- 13C4) is 13C labeled Arachidonic acid. Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function .
|
-
- HY-109120S1
-
-
- HY-W106014S
-
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Biphenyl-3-amine-13C6 hydrochloride
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Isotope-Labeled Compounds
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Others
|
|
[1,1'-Biphenyl]-3-amine-13C6 hydrochloride (Biphenyl-3-amine-13C6 hydrochloride) is the 13C labeled isotope of [1,1'-Biphenyl]-3-amine hydrochloride (HY-W106014) .
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![[1,1'-Biphenyl]-3-amine-13C6 hydrochloride](//file.medchemexpress.eu/product_pic/hy-w106014s.gif)
- HY-113365S2
-
|
4-Cholesten-3-one-13C2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Cholestenone- 13C2 is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells .
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- HY-129974S
-
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3,3'-T2-13C6
|
COX
Endogenous Metabolite
|
Metabolic Disease
|
|
3,3'-Diiodo-L-thyronine- 13C6 is the 13C labeled 3,3'-Diiodo-L-thyronine . 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity .
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-
- HY-13017S4
-
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VX-770-13C6
|
Isotope-Labeled Compounds
CFTR
Autophagy
|
Endocrinology
|
|
Ivacaftor- 13C6 (VX-770- 13C6) is 13C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
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-
- HY-18569S4
-
|
Indole-3-acetic acid-13C6; 3-IAA-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Indoleacetic acid- 13C6 is the 13C labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
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- HY-19528S2
-
|
|
Endogenous Metabolite
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Metabolic Disease
|
|
SAH- 13C10 is the 13C labeled SAH . SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .
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-
- HY-B0389S12
-
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Glucose-13C-2; D-(+)-Glucose-13C-2; Dextrose-13C-2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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-
- HY-B0389S9
-
|
Glucose-13C3-2; D-(+)-Glucose-13C3-2; Dextrose-13C3-2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C3-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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- HY-113365S1
-
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4-Cholesten-3-one-13C
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Cholestenone- 13C is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells .
|
-
- HY-W750297
-
|
4,4'-DDD-13C12; p,p'-Dichlorodiphenyl dichloroethane-13C12
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
p,p'-DDD- 13C12 is 13C labeled p,p'-DDD. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT .
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-
- HY-B0214S3
-
-
- HY-15772S1
-
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AZD-9291-13C,d3; Mereletinib-13C,d3
|
EGFR
|
Cancer
|
|
Osimertinib- 13C,d3 is the deuterium and 13C labeled Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively.
|
-
- HY-15388S2
-
|
AGN 190168-13C6
|
Isotope-Labeled Compounds
RAR/RXR
Autophagy
|
Inflammation/Immunology
Cancer
|
|
Tazarotene- 13C6 (AGN 190168- 13C6) is 13C labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-17007S2
-
-
- HY-B0495S7
-
|
LTG-13C; BW430C-13C
|
Isotope-Labeled Compounds
|
Neurological Disease
Cancer
|
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Lamotrigine- 13C (LTG- 13C) is 13C labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .
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-
- HY-12009S
-
|
GW786034-13C,d3 hydrochloride
|
VEGFR
PDGFR
Autophagy
c-Fms
FGFR
c-Kit
|
Cancer
|
|
Pazopanib- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Pazopanib hydrochloride . Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively .
|
-
- HY-B0511S3
-
|
Vitamin B7-13C5; Vitamin H-13C5; D-Biotin-13C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Biotin- 13C5 (Vitamin B7- 13C5) is 13C labeled Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
|
-
- HY-103447S2
-
|
Mycotoxin F2-13C7; Toxin F2-13C7
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Others
|
|
Zearalenone- 13C7 (Mycotoxin F2- 13C7) is 13C labeled Zearalenone. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
|
-
- HY-W748354
-
|
2,2',4,4',6,6'-Hexachlorobiphenyl-13C12
|
Isotope-Labeled Compounds
|
Others
|
|
2,2',4,4',6,6'-Hexachloro-1,1'-biphenyl- 13C12 (2,2',4,4',6,6'-Hexachlorobiphenyl- 13C12) is 13C labeled 2,2',4,4',6,6'-Hexachloro-1,1'-biphenyl .
|
-
- HY-B0152S1
-
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Adenine-8-C13; 9H-Purin-6-amine-8-13C
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
|
Adenine- 13C is the 13C labeled Adenine . Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis .
|
-
- HY-W777583
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6 is the 13C labeled isotope of 2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6 (HY-W777583) .
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-
![2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6](//file.medchemexpress.eu/product_pic/hy-w777583.gif)
- HY-17043S3
-
-
- HY-W653930
-
|
Bisphenol S-13C12; Bis(4-hydroxyphenyl) sulfone-13C12
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
4,4'-Sulfonyldiphenol- 13C12 (Bisphenol S- 13C12) is 13C labeled 4,4'-Sulfonyldiphenol. 4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-10285S2
-
|
BMS-477118-13C2
|
Isotope-Labeled Compounds
Dipeptidyl Peptidase
|
Metabolic Disease
|
|
Saxagliptin- 13C2 (BMS-477118- 13C2) is 13C labeled Saxagliptin. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research .
|
-
- HY-W017522S3
-
|
Hexanedioic acid-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
HSV
|
Infection
Metabolic Disease
|
|
Adipic acid- 13C (Hexanedioic acid- 13C) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc .
|
-
- HY-136406S
-
|
|
Isotope-Labeled Compounds
ATP Synthase
|
Cancer
|
|
Bongkrekic acid- 13C28 is the 13C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .
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-
- HY-78139S
-
|
L-(-)-Xylose-1-13C
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
|
|
L-Xylose-1- 13C (L-(-)-Xylose-1- 13C) is the 13C labeled L-Xylose (HY-78139). L-Xylose (L-(-)-Xylose) is a rare sugar and the levorotatory form of Xylose (HY-N0537). L-Xylose can be used as a raw material for the synthesis of various drugs and bioactive molecules .
|
-
- HY-B1227S1
-
|
|
FAAH
COX
Autophagy
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Carprofen- 13C,d3 is the deuterium and 13C labeled Carprofen . Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively .
|
-
- HY-78139S2
-
|
L-(-)-Xylose-5-13C
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
|
|
L-Xylose-5- 13C (L-(-)-Xylose-5- 13C) is the 13C labeled L-Xylose (HY-78139). L-Xylose (L-(-)-Xylose) is a rare sugar and the levorotatory form of Xylose (HY-N0537). L-Xylose can be used as a raw material for the synthesis of various drugs and bioactive molecules .
|
-
- HY-10208S1
-
|
GW786034-13C,d3
|
VEGFR
PDGFR
Autophagy
FGFR
c-Kit
|
Cancer
|
|
Pazopanib- 13C,d3 is the deuterium and 13C labeled Pazopanib . Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively .
|
-
- HY-14879S2
-
|
NXL-104-13C5
|
Isotope-Labeled Compounds
Antibiotic
Beta-lactamase
Bacterial
|
Infection
|
|
Avibactam sodium salt- 13C5 (NXL-104- 13C5) is 13C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively .
|
-
- HY-N0729S3
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
|
Linoleic acid- 13C1 is the 13C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
|
-
- HY-78139S1
-
|
L-(-)-Xylose-2-13C
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
|
|
L-Xylose-2- 13C ((L-(-)-Xylose-2- 13C)) is the 13C labeled L-Xylose (HY-78139). L-Xylose (L-(-)-Xylose) is a rare sugar and the levorotatory form of Xylose (HY-N0537). L-Xylose can be used as a raw material for the synthesis of various drugs and bioactive molecules .
|
-
- HY-12956S2
-
-
- HY-10450S5
-
|
|
Isotope-Labeled Compounds
SGLT
|
Metabolic Disease
Cancer
|
|
Dapagliflozin- 13C6-1 is 13C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .
|
-
- HY-B1290S3
-
|
Phenylethyl alcohol-13C2; Phenethyl alcohol-13C2; Benzyl carbinol-13C2
|
Bacterial
Virus Protease
Isotope-Labeled Compounds
|
Infection
|
|
2-Phenylethanol- 13C2 is 13C labeled 2-Phenylethanol (HY-B1290). 2-Phenylethanol (Phenethyl alcohol) is an aromatic alcohol with a rose-like odour. 2-Phenylethanol is a flavour and fragrance compound, and can be used as a preservative and anti-microbial agent. 2-Phenylethanol has antityrosinase and antimicrobial activities .
|
-
- HY-B0760S1
-
|
FNF acid-13C8
|
Isotope-Labeled Compounds
COX
PPAR
|
Metabolic Disease
|
|
Fenofibric acid- 13C8 (FNF acid- 13C8) is 13C labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 μM, 1.47 μM, and 1.06 μM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
|
-
- HY-N0729S2
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
|
Linoleic acid- 13C18 is the 13C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
|
-
- HY-113038AS
-
|
2-Hydroxyglutarate-13C5 disodium; 2-Hydroxyglutaric acid-13C5 sodium; 2-Hydroxypentanedioic acid-13C5 disodium
|
Histone Demethylase
Endogenous Metabolite
|
Cancer
|
|
α-Hydroxyglutaric acid- 13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .
|
-
- HY-B0363S1
-
|
R805-13C6
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
|
Nimesulide- 13C6 (R805- 13C6) is 13C labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.
|
-
- HY-15550S1
-
|
|
Drug Metabolite
|
Inflammation/Immunology
|
|
4'-Hydroxy diclofenac- 13C6 is the 13C labeled 4'-Hydroxy diclofenac . 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .
|
-
- HY-121309S1
-
|
Adriamycin aglycone-13C,d3; Adriamycinone-13C,d3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
Doxorubicinone- 13C,d3 (Adriamycin aglycone- 13C,d3) is 13C labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
|
-
- HY-115767S
-
|
1,2-Dioleoyl-rac-glycerol-CC3
|
Isotope-Labeled Compounds
PKC
|
Others
|
|
(±)-1,2-Diolein- 13C3 (1,2-Dioleoyl-rac-glycerol- 13C3) is 13C labeled (±)-1,2-Diolein. (±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein increases myotubes Ca 2+ influx .
|
-
- HY-W777649
-
-
- HY-W017522S1
-
|
Hexanedioic acid-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
HSV
|
Infection
Metabolic Disease
|
|
Adipic acid- 13C6 (Hexanedioic acid- 13C6) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc .
|
-
- HY-17498S3
-
-
- HY-A0118S1
-
|
NKTR-118-13C,d2; AZ-13337019-13C,d2
|
Isotope-Labeled Compounds
Opioid Receptor
|
Neurological Disease
Cancer
|
|
Naloxegol- 13C,d2 (NKTR-118- 13C,d2) is 13C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .
|
-
- HY-14740S2
-
|
GS-9137-13C6 ; JTK-303-13C6 ; D06677-13C6
|
Isotope-Labeled Compounds
HIV Integrase
HIV
|
Infection
|
|
Elvitegravir- 13C6 (GS-9137- 13C6) is 13C labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
|
-
- HY-W015851S2
-
|
(R)-(-)-3-Hydroxybutanoic acid-13C4 sodium; (R)-3-Hydroxybutyric acid-13C4 sodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-3-Hydroxybutanoic acid- 13C4 sodium is a 13C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
|
-
- HY-W017522S6
-
|
Hexanedioic acid-13C2
|
Isotope-Labeled Compounds
Endogenous Metabolite
HSV
|
Infection
Metabolic Disease
|
|
Adipic acid- 13C2 (Hexanedioic acid- 13C2) is 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc .
|
-
- HY-N6719S
-
|
|
Isotope-Labeled Compounds
|
Infection
|
|
Fumonisin B1- 13C34 is the 13C labeled Fumonisin B1 (HY-N6719) . Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .
|
-
- HY-16504S
-
-
- HY-B0497BS
-
|
BAY2353-13C6 monohydrate
|
STAT
Parasite
Antibiotic
|
Cancer
|
|
Niclosamide- 13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate . Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research . Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells . Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .
|
-
- HY-B0512S1
-
|
RP2632-13C6
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Sulfamerazine- 13C6 (RP2632- 13C6) is 13C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.
|
-
- HY-B0122S1
-
-
- HY-B0227S3
-
|
RP-19583-13C6
|
Isotope-Labeled Compounds
COX
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Ketoprofen- 13C6 (RP-19583- 13C6) is 13C labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .
|
-
- HY-W008125S
-
|
Methyl acetobromo-α-D-glucuronate-13C6 methyl ester
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Acetobromo-a-D-glucuronic acid- 13C6 methyl ester (Methyl acetobromo-α-D-glucuronate- 13C6 methyl ester) is 13C labeled Acetobromo-α-D-glucuronic acid methyl ester, 98%. Acetobromo-α-D-glucuronic acid methyl ester, 98% (Acetobromo-alpha-D-glucuronic acid methyl ester, 98%) can be used in glycobiology research and can undergo glycosylation reactions with suitable glycoside receptors.
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-
- HY-B0252S2
-
|
HCTZ-13C6
|
TGF-beta/Smad
Potassium Channel
|
Metabolic Disease
|
|
Hydrochlorothiazide- 13C6 is the 13C labeled Hydrochlorothiazide . Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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-
- HY-A0118S
-
|
NKTR-118-13C,d3; AZ-13337019-13C,d3
|
Isotope-Labeled Compounds
|
Neurological Disease
Cancer
|
|
Naloxegol- 13C,d3 (NKTR-118- 13C,d3) is 13C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .
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-
- HY-W778391
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Bisphenol A- 13C2 is 13C labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .
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-
- HY-N6779S
-
|
Terinin-13C7
|
Isotope-Labeled Compounds
|
Infection
|
|
Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
|
-
- HY-B1125S
-
-
- HY-N0368S1
-
|
|
Apoptosis
Endogenous Metabolite
iGluR
Bacterial
Isotope-Labeled Compounds
|
Cancer
|
|
Linalool- 13C3 is 13C labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
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-
- HY-B0228S10
-
|
(R)-(-)-3-Hydroxybutanoic acid-13C2 sodium; (R)-3-Hydroxybutyric acid-13C2 sodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-3-Hydroxybutanoic acid- 13C2 (sodium) is the 13C labeled (R)-3-Hydroxybutanoic acid (sodium) (HY-W015851). (R)-3-Hydroxybutanoic acid (sodium) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
|
-
- HY-W769714
-
|
T-705-13C3
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Favipiravir- 13C3 is the 13C labeled isotope of Favipiravir- 13C3(HY-14768 ).Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
|
-
- HY-Y0921S3
-
|
1,2-(RS)-Propanediol-13C3; 1,2-Propylene glycol-13C3; Propylene glycol-13C3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
|
|
(±)-1,2-Propanediol- 13C3 is 13C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish .
|
-
- HY-10450S3
-
|
BMS-512148-13C6
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Dapagliflozin- 13C6 (BMS-512148- 13C6) is 13C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .
|
-
- HY-14397S3
-
|
Indometacin-13C6
|
Isotope-Labeled Compounds
COX
Antibiotic
Influenza Virus
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Indomethacin- 13C6 (Indometacin- 13C6) is 13C labeled Indomethacin. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .
|
-
- HY-152040S
-
|
3-(Acetyl-13C2)-5-((S)-sec-butyl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one
|
Isotope-Labeled Compounds
|
Others
|
|
Tenuazonic acid-(acetyl- 13C2) (mixture of diastereomers) in methanol (3-(Acetyl- 13C2)-5-((S)-sec-butyl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one) is 13C labeled Tenuazonic acid-(acetyl) (mixture of diastereomers) in methanol .
|
-
- HY-W654002
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
(3R)-3-Hydroxybutyric acid-1- 13C is 13C labeled (R)-3-Hydroxybutanoic acid. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones .
|
-
- HY-19717S
-
|
S-[(1E)-1,2-Dichloroethenyl]-L-cysteine-13C3,15N
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
DCVC- 13C3, 15N is 15N and 13C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures .
|
-
- HY-W653989
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Desonide- 13C3 is the 13C labeled isotope of Desonide (HY-B0248). Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis .
|
-
- HY-B0228S1
-
|
Adenine riboside-13C5; D-Adenosine-13C5
|
Apoptosis
Nucleoside Antimetabolite/Analog
Autophagy
Endogenous Metabolite
|
Cancer
|
|
Adenosine- 13C5 is the 13C labeled Adenosine . Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .
|
-
- HY-B0637S2
-
|
BM15075-13C6
|
Isotope-Labeled Compounds
PPAR
|
Cardiovascular Disease
Metabolic Disease
|
|
Bezafibrate- 13C6 (BM15075- 13C6) is 13C labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
|
-
- HY-W021040S
-
|
CGA-173506-13C3
|
Isotope-Labeled Compounds
Fungal
Apoptosis
|
Infection
Cancer
|
|
Fludioxonil- 13C3 (CGA-173506- 13C3) is 13C labeled Fludioxonil. Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells .
|
-
- HY-W778008
-
|
|
Isotope-Labeled Compounds
GABA Receptor
|
Neurological Disease
|
|
Rac-Vigabatrin- 13C,d2 (Major) is the deuterium and 13C labeled Vigabatrin (HY-15399). Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .
|
-
- HY-14854S
-
|
ATI-5923-13C,d3
|
Isotope-Labeled Compounds
VKOR
|
Cardiovascular Disease
|
|
Tecarfarin- 13C,d3 (ATI-5923- 13C,d3) is 13C labeled Tecarfarin. Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X . Tecarfarin has the antithrombotic activity .
|
-
- HY-B0256S1
-
|
BW 57-322-13C4
|
Isotope-Labeled Compounds
|
Others
|
|
Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .
|
-
- HY-B0421S2
-
|
Mycophenolate-13C17
|
Isotope-Labeled Compounds
Flavivirus
|
Cancer
|
|
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
|
-
- HY-W585956
-
|
3,4,4′-Trichlorocarbanilide-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
Triclocarban- 13C6 is the 13C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
|
-
- HY-N0803S1
-
|
β-Myrcene-13C3
|
NF-κB
Isotope-Labeled Compounds
|
Others
|
|
Myrcene- 13C3 is 13C labeled Myrcene (HY-N0803). Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .
|
-
- HY-13458S2
-
|
L-DOPS-13C6; DOPS-13C6; SM5688-13C6
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
Droxidopa- 13C6 (L-DOPS- 13C6) is 13C labeled Droxidopa. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder) .
|
-
- HY-103447S1
-
|
Mycotoxin F2-13C18; Toxin F2-13C18
|
Isotope-Labeled Compounds
|
Others
|
|
Zearalenone- 13C18 (Mycotoxin F2- 13C18; Toxin F2- 13C18) is the 13C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
|
-
- HY-N0728S3
-
|
|
Isotope-Labeled Compounds
PI3K
Akt
|
Cardiovascular Disease
Cancer
|
|
α-Linolenic acid- 13C18 is the 13C labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .
|
-
- HY-W018772S15
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
D-Ribose(mixture of isomers)- 13C5 isomers)- 13C5 is the 13C labeled D-Ribose(mixture of isomers) . D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .
|
-
- HY-114370S
-
|
LOXO-292-13C,d3
|
Isotope-Labeled Compounds
|
Cancer
|
|
Selpercatinib- 13C,d3 (LOXO-292- 13C,d3) is 13C labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity .
|
-
- HY-113420S2
-
|
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
11-Dehydro-thromboxane B2- 13C5 is 13C labeled 11-Dehydro-thromboxane B2 (HY-113420). 11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis .
|
-
- HY-N6801S
-
|
|
Isotope-Labeled Compounds
|
Infection
|
|
Nivalenol- 13C15 is the 13C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .
|
-
- HY-B1075AS
-
|
MK-0955 (benzylamine)-13C3
|
Bacterial
Antibiotic
|
Infection
|
|
(Rac)-Fosfomycin (benzylamine)- 13C3 is the 13C labeled Fosfomycin . Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
|
-
- HY-14894S2
-
|
ASP1941-13C6
|
Isotope-Labeled Compounds
SGLT
|
Metabolic Disease
|
|
Pragliflozin- 13C6 (ASP1941- 13C6) is 13C labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
|
-
- HY-Y0051S
-
|
2-Hydroxymethyl-5-furfural-13C6; 2-Formyl-5-hydroxymethylfuran-13C6
|
Isotope-Labeled Compounds
Fungal
|
Others
|
|
5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
|
-
- HY-W654020
-
|
Propyl parahydroxybenzoate-13C6; Propyl 4-hydroxybenzoate-13C6
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
Bacterial
|
Infection
|
|
Propyl paraben- 13C6 (Propyl parahydroxybenzoate- 13C6) is 13C labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats .
|
-
- HY-B0251S1
-
|
Epoxymexrenone-13C,d3
|
Isotope-Labeled Compounds
Mineralocorticoid Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Cancer
|
|
Eplerenone- 13C,d3 (Epoxymexrenone- 13C,d3) is 13C labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
|
-
- HY-17416S2
-
|
|
Adrenergic Receptor
Isotope-Labeled Compounds
|
Cardiovascular Disease
Endocrinology
|
|
Guanfacine- 13C,d5 hydrochloride is the deuterium and 13C labeled Guanfacine hydrochloride (HY-17416). Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) .
|
-
- HY-10260S2
-
|
ZD6474-13C6
|
Isotope-Labeled Compounds
VEGFR
Autophagy
Apoptosis
|
Cancer
|
|
Vandetanib- 13C6 is a 13C labeled Vandetanib (HY-10260) . Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
|
-
- HY-18767S2
-
|
AG-120-13C5
|
Isotope-Labeled Compounds
Isocitrate Dehydrogenase (IDH)
|
Metabolic Disease
Cancer
|
|
Ivosidenib- 13C5 (AG-120- 13C5) is 13C labeled Ivosidenib. Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity .
|
-
- HY-59354S1
-
|
1,2-Dihydro-3,6-pyridazine-13C4-dione; 3,6-Dihydroxypyridazine-13C4; 3,6-Pyridazine-13C4-diol; Maleic hydrazide-13C4
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Cancer
|
|
1,2-Dihydropyridazine-3,6-dione-3,4,5,6- 13C4 (1,2-Dihydro-3,6-pyridazine- 13C4-dione) is 13C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
|
-
- HY-Y0045S
-
|
1-(1,3-Thiazol-2-yl)ethanone-13C2; 1-(Thiazol-2-yl)ethanone-13C2; Methyl 2-thiazolyl ketone-13C2
|
Isotope-Labeled Compounds
|
Others
|
|
2-Acetylthiazole- 13C2 is 13C labeled 2-Acetylthiazole (HY-Y0045). 2-Acetylthiazole (1-(1,3-Thiazol-2-yl)ethanone; 1-(Thiazol-2-yl)ethanone; Methyl 2-thiazolyl ketone) is a flavor compound. 2-Acetylthiazole is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-W008614S1
-
|
AG-1813-13C6
|
Isotope-Labeled Compounds
Proton Pump
Drug Metabolite
|
Metabolic Disease
|
|
Lansoprazole sulfone- 13C6 (AG-1813- 13C6) is 13C labeled Lansoprazole sulfone. Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H +, K +-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H +, K +-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .
|
-
- HY-N9484S
-
|
|
Drug Metabolite
Isotope-Labeled Compounds
|
Others
|
|
Menthofuran- 13C2 is 13C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .
|
-
- HY-14171S2
-
|
LGD1069-13C6
|
Isotope-Labeled Compounds
RAR/RXR
Autophagy
|
Cancer
|
|
Bexarotene- 13C6 (LGD1069- 13C6) is 13C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
|
-
- HY-14520S2
-
|
L-5,6,7,8-Tetrahydrofolic acid-13C6; L-Tetrahydrofolic acid-13C6
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Tetrahydrofolic acid- 13C6 (L-5,6,7,8-Tetrahydrofolic acid- 13C6) is 13C labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
|
-
- HY-B0158S7
-
|
Cytosine β-D-riboside-13C9; Cytosine-1-β-D-ribofuranoside-13C9
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Cytidine- 13C9 (Cytosine β-D-riboside- 13C9; Cytosine-1-β-D-ribofuranoside- 13C9) is 13C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .
|
-
- HY-137522AS1
-
|
3'-Azido-3'-deoxythymidine β-D-glucuronide-13C6
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Zidovudine Glucuronide- 13C6 (3'-Azido-3'-deoxythymidine β-D-glucuronide- 13C6) is 13C labeled Zidovudine O-β-D-glucuronide. Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .
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-
- HY-18341S4
-
-
- HY-113455S1
-
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(+)-α-Dimophecolic acid-13C18
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
|
Cancer
|
|
9(S)-HODE- 13C18 ((+)-α-Dimophecolic acid- 13C18) is 13C labeled 9S-HODE. 9S-HODE (Alpha-dimorphecolic acid) is an octadecadienoic acid and the main active derivative of linoleic acid, which can reduce the viability of HL-60 cells and induce apoptosis. 9S-HODE is rich in lipid peroxidation (LPO) products and is almost an ideal marker for LPO .
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-
- HY-N6745S
-
|
|
Na+/K+ ATPase
Apoptosis
Isotope-Labeled Compounds
|
Infection
|
|
Citreoviridin- 13C23 is 13C labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-B0656AS3
-
|
LY307640-13C,d3 sodium
|
Isotope-Labeled Compounds
Apoptosis
Bacterial
Proton Pump
|
Inflammation/Immunology
Cancer
|
|
Rabeprazole- 13C,d3 (sodium) (LY307640- 13C,d3 (sodium)) is 13C labeled Rabeprazole (sodium). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .
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-
- HY-N0322S5
-
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Estrogen Receptor/ERR
Endogenous Metabolite
|
Metabolic Disease
|
|
Cholesterol- 13C2 is the 13C labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .
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- HY-W013636S3
-
|
Alpha-Ketoglutaric acid-13C
|
Isotope-Labeled Compounds
Endogenous Metabolite
Tyrosinase
|
Neurological Disease
Metabolic Disease
|
|
2-Ketoglutaric acid- 13C (Alpha-Ketoglutaric acid- 13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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- HY-W013636S4
-
|
Alpha-Ketoglutaric acid-13C2
|
Isotope-Labeled Compounds
Tyrosinase
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
2-Ketoglutaric acid- 13C2 (Alpha-Ketoglutaric acid- 13C2) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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- HY-W779193
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline-2- 13C is 13C labeled 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine. 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine is a mutagenic compound .
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-
![2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline-2-13C](//file.medchemexpress.eu/product_pic/hy-w779193.gif)
- HY-10574S1
-
|
R278474-13C6; TMC278-13C6; DB08864-13C6
|
Isotope-Labeled Compounds
HIV
Reverse Transcriptase
|
Infection
|
|
Rilpivirine- 13C6 (R278474- 13C6) is 13C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .
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-
- HY-17416AS1
-
|
|
Adrenergic Receptor
Isotope-Labeled Compounds
|
Neurological Disease
Endocrinology
|
|
Guanfacine- 15N3, 13C2 is 15N and 13C labeled Guanfacine (HY-17416A). Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) .
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-
- HY-N0349S1
-
|
Methyl 4-hydroxybenzoate-13C6
|
Isotope-Labeled Compounds
Bacterial
Endogenous Metabolite
|
Infection
|
|
Methyl Paraben- 13C6 (Methyl 4-hydroxybenzoate- 13C6) is a 13C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .
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- HY-10121S4
-
-
- HY-W013636S
-
|
Alpha-Ketoglutaric acid-13C5
|
Isotope-Labeled Compounds
Tyrosinase
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
2-Ketoglutaric acid- 13C5 (Alpha-Ketoglutaric acid- 13C5) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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- HY-14520S1
-
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L-5,6,7,8-Tetrahydrofolic acid-13C5; L-Tetrahydrofolic acid-13C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Tetrahydrofolic acid- 13C5 (L-5,6,7,8-Tetrahydrofolic acid- 13C5) is 13C labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
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-
- HY-U00462S
-
|
|
Isotope-Labeled Compounds
Hexokinase
|
Metabolic Disease
Cancer
|
|
D-Mannoheptulose- 13C is the 13C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .
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- HY-B0322S1
-
|
Ro 4-2130-13C6
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Sulfamethoxazole- 13C6 (Ro 4-2130- 13C6) is a 13C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .
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- HY-W749691
-
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(S)-GS-5816-13C,d3
|
Isotope-Labeled Compounds
SARS-CoV
HCV
|
Infection
Inflammation/Immunology
Cancer
|
|
(S)-Velpatasvir- 13C,d3 ((S)-GS-5816- 13C,d3) is 13C labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
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- HY-W777582
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
4-tert-Octylphenol monoethoxylate- 13C6 is the 13C labeled isotope of 4-tert-Octylphenol monoethoxylate (HY-W777582) . 4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent .
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-
- HY-W747703
-
-
- HY-113209S2
-
|
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Others
|
|
8-Isoprostaglandin F2α- 13C5 is 13C labeled 8-Isoprostaglandin F2α (HY-113209). 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
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- HY-B2221S1
-
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|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
U- 13C Cellulose from chicory is the 13C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .
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- HY-B2221S5
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
U- 13C Cellulose from broccoli is the 13C labeled Cellulose (HY-B2221). Cellulose is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .
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-
- HY-113046S1
-
|
5-Methyl THF-13C6; 5-MTHF-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
|
5-Methyltetrahydrofolic acid- 13C6 (5-Methyl THF- 13C6) is 13C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .
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-
- HY-B1805S1
-
|
3,4,4'-Trichlorocarbanilide-13C13
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Triclocarban- 13C13 (3,4,4'-Trichlorocarbanilide- 13C13) is 13C labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
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-
- HY-A0004S
-
|
5-Aza-2'-deoxycytidine-13C5; 5-AZA-CdR-13C5; NSC 127716-13C5
|
Isotope-Labeled Compounds
DNA Methyltransferase
Nucleoside Antimetabolite/Analog
Apoptosis
|
Cancer
|
|
Decitabine- 13C5 (5-Aza-2'-deoxycytidine- 13C5) is 13C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .
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-
- HY-B0122S
-
-
- HY-W011577S1
-
|
2,3-Benzotriphenylene-13C6
|
Isotope-Labeled Compounds
Photosensitizer
|
Cancer
|
|
Dibenzo[a,c]anthracene- 13C6 (2,3-Benzotriphenylene- 13C6) is 13C labeled Benzo[f]tetraphene. Benzo[f]tetraphene (Dibenz[a,c]anthracene) is a polycyclic aromatic hydrocarbon with significant antitumor activity. Benzo[f]tetraphene is used as a luminescent probe in cell biology research and can effectively detect reactive oxygen species in biological systems. Benzo[f]tetraphene can also be used as a potential photosensitizer and shows good application prospects in photodynamic inhibition.
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-
![Dibenzo[a,c]anthracene-13C6](//file.medchemexpress.eu/product_pic/hy-w011577s1.gif)
- HY-13716S
-
|
|
Isotope-Labeled Compounds
Apoptosis
Opioid Receptor
|
Cancer
|
|
Noscapine- 13C,d3 is a 13C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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-
- HY-78131S3
-
|
(±)-Ibuprofen-13C6
|
Isotope-Labeled Compounds
Apoptosis
Parasite
COX
|
Cancer
|
|
Ibuprofen- 13C6 ((±)-Ibuprofen- 13C6) is a 13C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
|
-
- HY-B0347S3
-
|
|
Calcium Channel
Caspase
Reactive Oxygen Species (ROS)
Apoptosis
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Lacidipine- 13C4 is 13C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .
|
-
- HY-15206S2
-
|
Glyburide-13C6
|
Isotope-Labeled Compounds
Autophagy
Mitochondrial Metabolism
Potassium Channel
CFTR
P-glycoprotein
|
Metabolic Disease
|
|
Glibenclamide- 13C6 (Glyburide- 13C6) is 13C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K + channel (KATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .
|
-
- HY-166898S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
trans Nonachlor- 13C10 is 13C labeled (1R,2R,3S,3aR,4R,7R,7aS)-1,2,3,4,5,6,7,8,8-Nonachloro-2,3,3a,4,7,7a-hexahydro-1H-4,7-methanoindene .
|
-
- HY-13771S1
-
|
Ursodeoxycholate-13C; Ursodiol-13C; UDCA-13C
|
Isotope-Labeled Compounds
G protein-coupled Bile Acid Receptor 1
FXR
Endogenous Metabolite
|
Cancer
|
|
Ursodeoxycholic acid- 13C is the 13C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active .
|
-
- HY-B2221S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
U- 13C Cellulose high DP from potato is the 13C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .
|
-
- HY-B2221S3
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
U- 13C Cellulose high DP from maize is the 13C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .
|
-
- HY-W007376S
-
|
3-Formylindole-13C3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Indole-3-carboxaldehyde- 13C (3-Formylindole- 13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin .
|
-
- HY-B1456AS
-
|
LILLY-53858-13C6 sodium hydrate
|
Isotope-Labeled Compounds
COX
Melanocortin Receptor
ERK
|
Inflammation/Immunology
|
|
Fenoprofen- 13C6 (LILLY-53858- 13C6) sodium hydrate is the 13C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
|
-
- HY-B0617S2
-
|
S-Adenosyl methionine-13C dihydrochloride; Ademetionine-13C hydrochloride; AdoMet-13C dihydrochloride
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
S-Adenosyl-L-methionine- 13C (S-Adenosyl methionine- 13C) dihydrochloride is the 13C labeled S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .
|
-
- HY-10218S1
-
|
RAD001-13C2,d4; SDZ-RAD-13C2,d4
|
Isotope-Labeled Compounds
Bacterial
Autophagy
FKBP
mTOR
Apoptosis
|
Cancer
|
|
Everolimus- 13C2,d4 (RAD001- 13C2,d4) is 13C labeled Everolimus. Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .
|
-
- HY-15236S1
-
|
RO 2433--d1,13C,15N2; GS-331007--d1,13C,15N2
|
HCV
Isotope-Labeled Compounds
|
Infection
|
|
PSI-6206-d1, 13C, 15N2 is 15N and 13C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
|
-
- HY-W747639
-
|
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Glycidyl Stearate- 13C3 is 13C labeled Glycidyl stearate. Oxiran-2-ylmethyl stearate is a compound belonging to the class of esters. It contains reactive oxirane or epoxy groups that give the molecule its unique properties. Oxiran-2-ylmethyl stearate is derived from stearic acid and epichlorohydrin, which are naturally occurring substances. Glycidyl stearate is commonly used in various industrial applications such as the production of coatings, adhesives and surfactants. It can also be used as a crosslinking agent in the manufacture of polymers and resins .
|
-
- HY-166906S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
cis-Nonachlor- 13C10 is 13C labeled (1R,2S,3S,3aR,4R,7R,7aS)-1,2,3,4,5,6,7,8,8-Nonachloro-2,3,3a,4,7,7a-hexahydro-1H-4,7-methanoindene .
|
-
- HY-B0124S2
-
|
AD 810-13C6; CI 912-13C6
|
Isotope-Labeled Compounds
Carbonic Anhydrase
Apoptosis
|
Neurological Disease
|
|
Zonisamide- 13C6 (AD 810- 13C6) is 13C labeled Zonisamide. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .
|
-
- HY-B0580S2
-
|
RS37619-13C6
|
Isotope-Labeled Compounds
Apoptosis
COX
|
Inflammation/Immunology
Cancer
|
|
Ketorolac- 13C6 (RS37619- 13C6) is 13C labeled Ketorolac. Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research .
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- HY-B0151S1
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3β-Hydroxy-5-pregnen-20-one-13C2,d2
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Isotope-Labeled Compounds
Autophagy
Cannabinoid Receptor
Endogenous Metabolite
TRP Channel
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Neurological Disease
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Pregnenolone- 13C2,d2 is the deuterium and 13C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .
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- HY-15463S3
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STI571-13C,d3; CGP-57148B-13C,d3
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Isotope-Labeled Compounds
Autophagy
SARS-CoV
Bcr-Abl
PDGFR
c-Kit
|
Cancer
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|
Imatinib- 13C,d3 (STI571- 13C,d3) is 13C labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and MERS-CoV .
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- HY-13690S1
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2,4′-DDD-13C6; o,p'-DDD-13C6
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Apoptosis
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Cancer
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Mitotane- 13C6 is the 13C labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
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- HY-N6739S
-
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Acyltransferase
Isotope-Labeled Compounds
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Infection
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Beauvericin- 13C45 is 13C labeled Beauvericin (HY-N6739). Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages .
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- HY-W779019
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D-(+)-Xylose-13C5; (+)-Xylose-13C5; Wood sugar-13C5
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Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
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Xylose- 13C5 (D-(+)-Xylose- 13C5) is 13C labeled Xylose. Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation .
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- HY-D0205AS1
-
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Carbocysteine-13C3-1
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Isotope-Labeled Compounds
Keap1-Nrf2
NF-κB
PERK
Apoptosis
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Infection
Inflammation/Immunology
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Carbocisteine- 13C3-1 (Carbocysteine- 13C3-1) is 13C labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research [13].
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- HY-B0579S3
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Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4; CsA-13C2,d4
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Isotope-Labeled Compounds
|
Inflammation/Immunology
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Cyclosporin A- 13C2,d4 (Cyclosporine A- 13C2,d4; Ciclosporin A- 13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .
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- HY-W653962
-
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Isotope-Labeled Compounds
Apoptosis
Antibiotic
Fungal
Bacterial
|
Infection
Cancer
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Triclosan- 13C6 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
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-
- HY-W747491
-
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|
Isotope-Labeled Compounds
Antibiotic
Apoptosis
Bacterial
Fungal
|
Cancer
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Triclosan- 13C12 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
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- HY-B1190S2
-
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BL-S 578-13C6
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Isotope-Labeled Compounds
Bacterial
Antibiotic
EAAT
|
Infection
Neurological Disease
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Cefadroxil- 13C6 (BL-S 578- 13C6) is 13C labeled Cefadroxil (HY-B1190). Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
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- HY-N0537S3
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D-(+)-Xylose-2-13C; (+)-Xylose-2-13C; Wood sugar-2-13C
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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Xylose-2- 13C (D-(+)-Xylose-2- 13C) is the 13C labeled Xylose (HY-N0537). Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation .
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- HY-143704S
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Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride
|
PPAR
NF-κB
PAK
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Metabolic Disease
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5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
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- HY-W778207
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Isotope-Labeled Compounds
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Others
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|
2'-Deoxyadenosine- 13C5 monohydrate is the 13C labeled isotope of '-Deoxyadenosine monohydrate (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .
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- HY-130462S2
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POPC-13C16; 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine-13C16
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Isotope-Labeled Compounds
Liposome
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Others
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC- 13C16 (POPC- 13C16) is 13C labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers .
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- HY-W040240S
-
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Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
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|
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- 13C is the 13C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite .
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- HY-W014901S1
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-
- HY-W011683S3
-
|
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Isotope-Labeled Compounds
Endogenous Metabolite
Nucleoside Antimetabolite/Analog
Caspase
Apoptosis
|
Metabolic Disease
Endocrinology
Cancer
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2'-Deoxyadenosine monohydrate-5′- 13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .
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-
- HY-W011683S
-
|
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Isotope-Labeled Compounds
Endogenous Metabolite
Nucleoside Antimetabolite/Analog
Caspase
Apoptosis
|
Metabolic Disease
Endocrinology
Cancer
|
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2'-Deoxyadenosine monohydrate-1′- 13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .
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- HY-W011683S1
-
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Isotope-Labeled Compounds
Endogenous Metabolite
Nucleoside Antimetabolite/Analog
Caspase
Apoptosis
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Metabolic Disease
Endocrinology
Cancer
|
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2'-Deoxyadenosine monohydrate-2′- 13C is the 13C labeled 2'-Deoxyadenosine monohydrate(HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .
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-
- HY-W014901S
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-
- HY-W040240S1
-
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|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- 13C-1 is the 13C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite .
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- HY-W040240S2
-
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Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- 13C-2 is the 13C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite .
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- HY-A0003S2
-
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CC-5013-13C5,15N
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Ligands for E3 Ligase
Apoptosis
Molecular Glues
Isotope-Labeled Compounds
|
Inflammation/Immunology
Cancer
|
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Lenalidomide- 13C5, 15N is 15N and 13C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .
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- HY-B0166S8
-
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L-Ascorbate-1; Vitamin C-13C6-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
Reactive Oxygen Species (ROS)
Calcium Channel
Apoptosis
|
Cancer
|
|
L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
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-
- HY-W011683S2
-
-
- HY-N6715S
-
|
|
Influenza Virus
Bacterial
Isotope-Labeled Compounds
|
Infection
|
|
Tenuazonic acid- 13C10 is 13C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
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-
- HY-13690S3
-
|
2,4′-DDD-13C12; o,p'-DDD-13C12
|
Isotope-Labeled Compounds
Apoptosis
|
Cancer
|
|
Mitotane- 13C12 (2,4′-DDD- 13C12) is 13C labeled Mitotane. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
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-
- HY-W127515S
-
|
Violet leaf aldehyde-13C2
|
Biochemical Assay Reagents
Isotope-Labeled Compounds
|
Others
|
|
trans-2,cis-6-Nonadienal- 13C2 is 13C labeled trans-2,cis-6-Nonadienal (HY-W127515). Trans-2, cis-6-NonadienalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2, cis-6-NonadienalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.
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-
- HY-W050154S
-
|
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Parasite
Isotope-Labeled Compounds
|
Infection
|
|
Kojic acid- 13C6 is 13C labeled Kojic acid (HY-W050154). Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .
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-
- HY-133968S1
-
|
Ostreasterol-13C
|
Isotope-Labeled Compounds
Acyltransferase
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
24-Methylenecholesterol- 13C (Ostreasterol- 13C) is the 13C labeled 24-Methylenecholesterol (HY-133968) . 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .
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-
- HY-W017443S4
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
L-Asparagine-1,2,3,4- 13C4 monohydrate is the 13C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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-
- HY-N7032S1
-
|
UDP-D-Glucose-13C6 disodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
P2Y Receptor
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
Uridine 5′-diphosphoglucose- 13C6 (UDP-D-Glucose- 13C6) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .
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- HY-N7032S
-
|
UDP-D-Glucose-13C disodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
P2Y Receptor
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
Uridine 5′-diphosphoglucose- 13C (UDP-D-Glucose- 13C) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .
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- HY-N6746S1
-
|
NSC 186-13C13
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Isotope-Labeled Compounds
Apoptosis
Bacterial
Autophagy
|
Infection
Neurological Disease
Cancer
|
|
Citrinin- 13C13 (NSC 186- 13C13) is the 13C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .
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-
- HY-18252S3
-
|
TA1790-13C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
Phosphodiesterase (PDE)
NO Synthase
|
Cardiovascular Disease
Endocrinology
|
|
Avanafil- 13C5 (TA1790- 13C5) is 13C labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .
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-
- HY-B0710S
-
|
Trimethylglycine-13C3; Carboxy-N,N,N-trimethylmethanaminium-13C3
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Betaine- 13C3 (Trimethylglycine- 13C3) is the 13C labeled isotope of Betaine (HY-B0710). Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns [1,2]. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity .
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-
- HY-N0059S
-
|
|
Isotope-Labeled Compounds
Parasite
Bacterial
AMPK
PPAR
|
Infection
Neurological Disease
Metabolic Disease
|
|
D-Arabinose- 13C is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
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-
- HY-B0660S1
-
|
EPA 1,2,3,4,5-13C, FA 20:5-13C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
Histone Demethylase
|
Neurological Disease
Cancer
|
|
Eicosapentaenoic acid 1,2,3,4,5- 13C5 (EPA 1,2,3,4,5- 13C, FA 20:5- 13C5) is 13C labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .
|
-
- HY-N0059S1
-
|
|
Isotope-Labeled Compounds
Parasite
Bacterial
AMPK
PPAR
|
Infection
Neurological Disease
Metabolic Disease
|
|
D-Arabinose- 13C-1 is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
|
-
- HY-N0059S2
-
|
|
Isotope-Labeled Compounds
Parasite
Bacterial
AMPK
PPAR
|
Infection
Neurological Disease
Metabolic Disease
|
|
D-Arabinose- 13C-2 is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
|
-
- HY-N0059S3
-
|
|
Isotope-Labeled Compounds
Parasite
Bacterial
AMPK
PPAR
|
Infection
Neurological Disease
Metabolic Disease
|
|
D-Arabinose- 13C-3 is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
|
-
- HY-N7082S
-
|
|
Isotope-Labeled Compounds
Parasite
Bacterial
AMPK
PPAR
|
Infection
Neurological Disease
Metabolic Disease
|
|
D-Arabinopyranos- 13C5 is 13C labeled D-Arabinopyranos (HY-N7082). D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
|
-
- HY-W009538S1
-
|
5-Fluoro-5'-deoxycytidine-13C5
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Drug Metabolite
|
Cancer
|
|
5'-Deoxy-5-fluorocytidine-13C5 is the 13C labeled isotope of 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-W127841
-
|
|
Biochemical Assay Reagents
|
|
Citric acid-2,4- 13C2 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1264F
-
|
|
nAChR
|
Neurological Disease
|
|
α-Bungarotoxin, FITC labeledis the FITC labelled α-Bungarotoxin (HY-P1264). α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs) .
|
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-A0070AS2
-
|
|
|
Liothyronine- 13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively .
|
-
-
- HY-B0035S2
-
|
|
|
Sulfamethazine- 13C6 is a 13C-labeled Sulfamethazine (HY-A0178). Sulfamethazine (Sulfadimidine) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections) .
|
-
-
- HY-W010575S
-
|
|
|
(2R)-3-Amino-2-fluoropropanoic acid- 13C3 is a 13C-labeled (2R)-3-Amino-2-fluoropropanoic acid. (2R)-3-Amino-2-fluoropropanoic acid is the catabolism of anticancer agent 5-Fluorouracil .
|
-
-
- HY-W777615
-
|
|
|
Ammeline Hydrochloride- 13C3 is the 13C-labeled
|
-
-
- HY-W008621S
-
|
|
|
Oleic acid- 13C (potassium) is a 13C-labeled Oleic acid.
|
-
-
- HY-W768206
-
|
|
|
D-Cellobiose- 13C12 is the 13C-labeled
|
-
-
- HY-W015339S
-
|
|
|
Octanoate- 13C sodium is a 13C-labeled Octanoate sodium .
|
-
-
- HY-W134007S
-
|
|
|
Hexadecanoate- 13C (potassium) is a 13C-labeled Hexadecanoate potassium .
|
-
-
- HY-W771066
-
|
|
|
Methyl L-Arabinopyranoside- 13C is the 13C-labeled
|
-
-
- HY-W770279
-
|
|
|
DL-Cytarabine- 13C3 is the 13C-labeled DL-Cytarabine.
|
-
-
- HY-W768304
-
|
|
|
D-(+)-Maltose Monohydrate- 13C12 is the 13C-labeled D-(+)-Maltose Monohydrate.
|
-
-
- HY-W766603
-
|
|
|
Thiouric Acid Sodium Salt Dihydrate- 13C3 is the 13C-labeled Thiouric Acid Sodium Salt Dihydrate.
|
-
-
- HY-W778773
-
|
|
|
Benz[a]anthracene-7-chloromethane- 13C is the 13C-labeled
|
-
![Benz[a]anthracene-7-chloromethane-13C](//file.medchemexpress.eu/product_pic/hy-w778773.gif)
-
- HY-118560S
-
|
|
|
Tricyclodecenyl acetate- 13C2 is 13C-labeled Tricyclodecenyl acetate (HY-118560).
|
-
-
- HY-W777286
-
|
|
|
rac Lenalidomide- 13C5 is a 13C-labeled rac Lenalidomide .
|
-
-
- HY-W009762S1
-
|
|
|
L-Lysine6- 13C (dihydrochloride) is a 13C-labeled L-Lysine dihydrochloride.
|
-
-
- HY-125296S
-
|
|
|
Fipronil sulfone- 13C6 is the 13C-labeled Fipronil sulfone .
|
-
-
- HY-141901S2
-
|
|
|
Dehydroepiandrosterone- 13C3 is a 13C-labeled and deuterium labeled Dehydroepiandrosterone .
|
-
-
- HY-N0090S
-
|
|
|
Guanosine-1'- 13C Monohydrate is the 13C-labeled Guanosine-1' Monohydrate .
|
-
-
- HY-W746880
-
|
|
|
D-Arabinose Phenylhydrazone- 13C5 is the 13C-labeled D-Arabinose Phenylhydrazone.
|
-
-
- HY-W768353
-
|
|
|
Lactulose- 13C is the 13C-labeled D-Lactulose (HY-N11175).
|
-
-
- HY-W768226
-
|
|
|
D-Fructose-1,2,3- 13C3 is the 13C-labeled
|
-
-
- HY-W750888
-
|
|
|
(Z)-Chlorolefin- 13C6 is the 13C-labeled (Z)-Chlorolefin- 13C6.
|
-
-
- HY-101064S
-
|
|
|
Fmoc-leucine- 13C is a 13C-labeled Boc-GlycineFmoc-leucine (HY-101064).
|
-
-
- HY-B2225AS
-
|
|
|
Starch from potato- 13C12 is the 13C-labeled Starch from potato .
|
-
-
- HY-W777877
-
|
|
|
Carbovir- 13C,d2 is the deuterium labeled and 13C-labeled Carbovir.
|
-
-
- HY-W777036
-
|
|
|
2,3-Dichlorobenzoic acid- 13C is the 13C-labeled 2,3-Dichlorobenzoic acid.
|
-
-
- HY-W750576
-
|
|
|
4-Octyl itaconate- 13C5 is the 13C-labeled 4-Octyl itaconate.
|
-
-
- HY-W777674
-
|
|
|
2,6-Deoxyfructosazine- 13C4 is the 13C-labeled 2,6-Deoxyfructosazine.
|
-
-
- HY-W751522
-
|
|
|
Olsalazine Dimethyl Ester- 13C12 is the 13C-labeled Olsalazine Dimethyl Ester (HY-W751524).
|
-
-
- HY-W654206
-
|
|
|
D-Glucose 6-Phosphate Sodium Salt Hydrate- 13C6 is the 13C-labeled D-Glucose 6-Phosphate Sodium Salt Hydrate.
|
-
-
- HY-W768168
-
|
|
|
N-Acetyl-D-neuraminic Acid- 13C2 is the 13C-labeled N-Acetyl-D-neuraminic Acid.
|
-
-
- HY-W781971
-
|
|
|
Estradiol 17-Benzoate- 13C2 is the 13C-labeled Estradiol 17-Benzoate.
|
-
-
- HY-W013495S
-
|
|
|
Porphobilinogen- 13C2 is the 13C-labeled Porphobilinogen. Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.
|
-
-
- HY-W778060
-
|
|
|
Benzaldehyde Semicarbazone- 13C is the 13C-labeled 2-Benzylidenehydrazinecarboxamide (HY-W010129).
|
-
-
- HY-W771023
-
|
|
|
Dihydroxydodecanedioic- 13C12 Acid 1-Ethyl Ester is the 13C-labeled Dihydroxydodecanedioic Acid 1-Ethyl Ester.
|
-
-
- HY-W748193
-
|
|
|
2,5-Furandicarboxylic acid- 13C6 is the 13C-labeled 2,5-Furandicarboxylic acid.
|
-
-
- HY-Y0781S
-
|
|
|
Pyruvic acid- 13C (sodium) is the 13C-labeled Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
|
-
-
- HY-W756758
-
|
|
|
Guanosine- 13C5 5'-Monophosphate is the 13C-labeled Guanosine 5'-Monophosphate.
|
-
-
- HY-W014375S2
-
|
|
|
Arginine- 13C6 hydrochloride is 13C-labeled Arginine (hydrochloride) (HY-W014375). Arginine hydrochloride is an arginine derivative.
|
-
-
- HY-W777622
-
|
|
|
ent-Calindol amide- 13C is the 13C-labeled ent-Calindol Amide (HY-W740666).
|
-
-
- HY-B0143S3
-
|
|
|
Niacin- 13C6 is the 13C-labeled Niacin. Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group.
|
-
-
- HY-128790S1
-
|
|
|
4-Methoxyestrone- 13C6 is a 13C-labeled 4-Methoxyestrone (HY-128790).
|
-
-
- HY-W751109
-
|
|
|
Methyl carbamimidothioate sulfate- 13C is the 13C-labeled Methyl carbamimidothioate sulfate (HY-W089554).
|
-
-
- HY-W779008
-
|
|
|
2-Hydroxyacetaldehyde- 13C2 is the 13C-labeled 2-Hydroxyacetaldehyde (HY-28911).
|
-
-
- HY-17383S
-
|
|
|
Levomefolate- 13C5 (calcium) is the 13C-labeled Levomefolate (calcium). Levomefolate calcium is an artificial form of folate.
|
-
-
- HY-W757436
-
|
|
|
(R)-Mertansine- 13C,d3 is the deuterium labeled and 13C-labeled (R)-Mertansine.
|
-
-
- HY-W768302
-
|
|
|
D-Lyxose- 13C5 is the 13C-labeled D-Lyxose. D-Lyxose is an?endogenous metabolite.
|
-
-
- HY-W749501
-
|
|
|
Methyl-beta-L-arabinopyranoside- 13C is the 13C-labeled Methyl-beta-L-arabinopyranoside (HY-W143275).
|
-
-
- HY-170207S
-
|
|
|
Aurothioglucose 70%- 13C6 is the 13C-labeled CRBN ligand-175 (HY-170207).
|
-
- HY-W015466S1
-
|
|
|
Acetylvaline-13C2 is the 13C-labeled Acetylvaline. Acetylvaline is an endogenous metabolite .
|
-
- HY-Y0289S
-
|
|
|
1-Dodecanol- 13C is the 13C-labeled 1-Dodecanol. 1-Dodecanol is an endogenous metabolite.
|
-
- HY-W778152
-
|
|
|
O,O-Dimethyl Phosphorothionate ammonium- 13C2 is the 13C-labeled O,O-Dimethyl Phosphorothionate ammonium.
|
-
- HY-W1110947
-
|
|
|
(S)-3-Phosphoglyceric acid- 13C3 sodium is the 13C-labeled (S)-3-Phosphoglyceric acid sodium.
|
-
- HY-N0437S2
-
|
|
|
Progesterone- 13C3 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
|
-
- HY-B0401S1
-
|
|
|
Tolbutamide- 13C is the 13C-labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
|
-
- HY-W653931
-
|
|
|
rac 1,2-Bis-palmitoyl-3-chloropropanediol- 13C3 is the 13C-labeled
|
-
- HY-W751098
-
|
|
|
Aldosterone- 13C3 is a 13C-labeled Aldosterone (HY-113313). Aldosterone is a primary mineralocorticoid and steroid hormone.
|
-
- HY-167810A
-
|
|
|
Cyclosporin A Acetate- 13C2,d4 is the deuterium labeled and 13C-labeled Cyclosporin A Acetate.
|
-
- HY-W771021
-
|
|
|
Dioxododecanedioic- 13C12 Acid 1,12-Diethyl Ester is the 13C-labeled Dioxododecanedioic Acid 1,12-Diethyl Ester.
|
-
- HY-N0437S1
-
|
|
|
Progesterone- 13C5 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
|
-
- HY-W770285
-
|
|
|
Bisphenol A bis-(β-D-glucuronide)- 13C12 sodium is the 13C-labeled Bisphenol A bis-(β-D-glucuronide).
|
-
- HY-N0437S3
-
|
|
|
Progesterone- 13C2 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
|
-
- HY-W010596S
-
|
|
|
Malonamide- 13C3 (METHANEDICARBOXYLIC ACID DIAMIDE- 13C3) is the 13C-labeled Malonamide (HY-W010596).
|
-
- HY-W778065
-
|
|
|
N-(tert-Butoxycarbonyl)aniline- 13C6 is the 13C-labeled tert-Butyl phenylcarbamate (HY-W009968).
|
-
- HY-143857S
-
|
|
|
22:0 Lyso PC- 13C6 is a 13C-labeled and deuterium labeled 22:0 Lyso PC .
|
-
- HY-Y0989S2
-
|
|
|
Acetophenone-1,2- 13C2 is the 13C-labeled Acetophenone. Acetophenone is an organic compound with simple structure .
|
-
- HY-W768283
-
|
|
|
Guanosine Hydrate- 13C5 (GUANINE RIBOSIDE HYDRATE- 13C5) is the 13C-labeled Guanosine Hydrate (HY-N0090).
|
-
- HY-W750442
-
|
|
|
4-Bromophenoxytriisopropylsilane- 13C6 is the 13C-labeled (4-Bromophenoxy)triisopropylsilane (HY-W702226).
|
-
- HY-157077S
-
|
|
|
5-Hydroxysaxagliptin- 13C,d2 (TFA) is 13C-labeled 5-Hydroxysaxagliptin .
|
-
- HY-N0680S3
-
|
|
|
Thiamine- 13C3 (hydrochloride) is the 13C-labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.
|
-
- HY-N0521AS
-
|
|
|
(+)-Gallocatechin- 13C3 is the 13C-labeled (+)-Gallocatechin. (+)-Gallocatechin is a polyphenol compound from green tea, possesses anticancer activity .
|
-
- HY-N6612S
-
|
|
|
D-Glucuronic acid sodium monohydrate- 13C6 is the 13C-labeled D-Glucuronic acid sodium salt monohydrate (HY-N6612A). D-Glucuronic acid sodium salt monohydrate is an endogenous metabolite.
|
-
- HY-147551S
-
|
|
|
3-Iodo-L-thyronine- 13C6 is the 13C-labeled 3-Iodo-L-thyronine (HY-W588264).
|
-
- HY-W015883S
-
|
|
|
Fumaric acid- 13C4 is the 13C-labeled Fumaric acid. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.
|
-
- HY-B0337S2
-
|
|
|
Sulfadimethoxine- 13C6 is the 13C-labeled Sulfadimethoxine. Sulfadimethoxine (Sulphadimethoxine) is a sulfonamide antibiotic used to treat many infections .
|
-
- HY-W751746
-
|
|
|
Dehydro Folic Acid 1,5-Dimethyl Ester- 13C5 is the 13C-labeled Dehydro Folic Acid 1,5-Dimethyl Ester.
|
-
- HY-W766769
-
|
|
|
Cyproterone Acetate- 13C2,d3 is 13C-labeled Cyproterone Acetate (HY-13604) .
|
-
- HY-W751475
-
|
|
|
1-(Methoxymethoxy)benzene- 13C6 is the 13C-labeled 1-(Methoxymethoxy)benzene (HY-W642289).
|
-
- HY-76847S2
-
|
|
|
Chenodeoxycholic acid- 13C is the 13C-labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
|
-
- HY-Y0842S
-
|
|
|
Formamide- 13C is the 13C-labeled Formamide. Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.
|
-
- HY-144427S
-
|
|
|
Vitamin E- 13C2,d6 is a 13C-labeled and deuterium labeled Vitamin E .
|
-
- HY-W766913
-
|
|
|
Moxifloxacin (N-Sulfate Disodium)- 13C,d3 is the deuterium labeled and 13C-labeled Moxifloxacin (N-Sulfate Disodium).
|
-
- HY-W769362
-
|
|
|
N-Methyl Ticlopidine- 13C,d3 Iodide is the deuterium labeled and 13C-labeled N-Methyl Ticlopidine Iodide.
|
-
- HY-W768990
-
|
|
|
Vinclozolin- 13C3,d3 is the deuterium and 13C-labeled Vinclozolin (HY-B2061).
|
-
- HY-100354S
-
|
|
|
C16-Ceramide- 13C16 is a 13C-labeled C16-Ceramide (HY-100354).
|
-
- HY-W012530S
-
|
|
|
Phenylpyruvic acid- 13C6 sodium is the 13C-labeled Phenylpyruvic acid. Phenylpyruvic acid is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase .
|
-
- HY-18102BS
-
|
|
|
GLPG0492- 13C,d3 (racemate) is 13C-labeled GLPG0492 (racemate) (HY-18102B) .
|
-
- HY-W776938
-
|
|
|
Ethyl nicotinate hydrochloride- 13C6 (Nicotinic acid ethylester hydrochloride- 13C6) is the 13C-labeled Ethyl nicotinate (HY-W013628).
|
-
- HY-B0456S2
-
|
|
|
Riboflavin- 13C5 is the 13C-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-W779236
-
|
|
|
Ethyl Propargylate- 13C3 (Propiolic acid ethyl ester- 13C3) is the 13C-labeled Ethyl propiolate (HY-Y0871).
|
-
- HY-W778202
-
|
|
|
2-Oxoacetic acid hydrate- 13C2 (Glyoxylic Acid monohydrate- 13C2) is the 13C-labeled 2-Oxoacetic acid hydrate (HY-W047499).
|
-
- HY-N0666S4
-
|
|
|
L-Aspartic acid- 13C4 is the 13C-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
|
-
- HY-W749645
-
|
|
|
Acrolein 2,4-Dinitrophenylhydrazone- 13C6 is the 13C-labeled Acrolein 2,4-dinitrophenylhydrazone (HY-W414289).
|
-
- HY-W771072
-
|
|
|
4-Hydroxybenzenesulfonic Acid- 13C6 is the 13C-labeled 4-Hydroxybenzenesulfonic acid,65+% in water (HY-W016793).
|
-
- HY-W778173
-
|
|
|
2-Benzyloxy-benzoic Acid Benzyl Ester- 13C6 is the 13C-labeled Benzyl 2-(benzyloxy)benzoate (HY-W702475).
|
-
- HY-W778774
-
|
|
|
Benz[a]anthracene-7-methanol- 13C is the 13C-labeled Tetraphen-7-ylmethanol (HY-W704173).
|
-
- HY-Y1088S
-
|
|
|
Hydrocinnamic acid-2,3- 13C2 is the 13C-labeled Hydrocinnamic acid. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities.
|
-
- HY-W748626
-
|
|
|
Acetic acid, 2-bromo-, hexadecyl ester- 13C2 is the 13C-labeled Acetic acid, 2-bromo-, hexadecyl ester (HY-W856683).
|
-
- HY-10002S
-
|
|
|
Calcitriol- 13C3 is the 13C-labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
|
-
- HY-W778300
-
|
|
|
Sodium 2-cyanoacetate- 13C2 (Sodium cyanoacetate- 13C2) is the 13C-labeled Sodium 2-cyanoacetate (HY-W129503).
|
-
- HY-50896S1
-
|
|
|
Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR .
|
-
- HY-N0771S
-
|
|
|
L-Isoleucine- 13C6 is the 13C-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid . L-Isoleucine is an essential amino acid.
|
-
- HY-144085S
-
|
|
|
D-Fructose-6-phosphate- 13C6 disodium x.hydrate is a 13C-labeled D-Fructose-6-phosphate disodium x.hydrate .
|
-
- HY-W749199
-
|
|
|
2-Ethyl toluene- 13C6 is the 13C-labeled 1-Ethyl-2-methylbenzene (HY-W008826).
|
-
- HY-W010098S1
-
|
|
|
Terephthalic acid- 13C2 is the 13C-labeled Terephthalic acid. Terephthalic acid is one isomer of the three phthalic, a precursor to the polyester PET, used to make clothing and plastic bottles.
|
-
- HY-B2219S2
-
|
|
|
Stearic acid- 13C18is the 13C-labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
|
-
- HY-Y0252S3
-
|
|
|
L-Proline- 13C is the 13C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
|
-
- HY-12857S
-
|
|
|
Brigatinib- 13C6 is the 13C-labeled Brigatinib. Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor, with an IC50 of 0.6 nM .
|
-
- HY-W747961
-
|
|
|
2-(4-(Methylsulfonamido)phenoxy)acetic Acid- 13C is the 13C-labeled 2-(4-(Methylsulfonamido)phenoxy)acetic acid (HY-W714806).
|
-
- HY-N0326S3
-
|
|
|
L-Methionine- 13C is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-79131S
-
|
|
|
Fmoc-Phe-OH- 13C6 is a 13C-labeled Fmoc-Phe-OH (HY-79131). Fmoc-Phe-OH is a phenylalanine derivative .
|
-
- HY-W013780S
-
|
|
|
Fmoc-Pro-OH- 13C is a 13C-labeled Fmoc-Pro-OH (HY-W013780). Fmoc-Pro-OH is a proline derivative .
|
-
- HY-B0504S1
-
|
|
|
Creatinine- 13C is the 13C-labeled Creatinine. Creatinine (NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.
|
-
- HY-B0412S3
-
|
|
|
Estriol- 13C3 is the 13C-labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
|
-
- HY-N0351S
-
|
|
|
p-Coumaric acid- 13C3 is the 13C-labeled p-Coumaric acid. p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities.
|
-
- HY-W768287
-
|
|
|
L-Idose (0.16M Aqueous Solution)- 13C is the 13C-labeled L-Idose (0.16M Aqueous Solution).
|
-
- HY-N0623S1
-
|
|
|
L-Tryptophan- 13C is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .
|
-
- HY-W014423S
-
|
|
|
L-Histidine- 13C (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-N0898S
-
|
|
|
Catechin- 13C3 is the 13C-labeled Catechin. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
|
-
- HY-108226S1
-
|
|
|
Regorafenib N-oxide and N-desmethyl (M5)- 13C6 is the 13C-labeled Regorafenib N-oxide and N-desmethyl (M5) .
|
-
- HY-N0771S4
-
1 Publications Verification
|
|
L-Isoleucine-1- 13C is the 13C-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid . L-Isoleucine is an essential amino acid.
|
-
- HY-W765992
-
|
|
|
N-Boc-erythro-sphingosine- 13C2,d2 is the deuterium labeled and 13C-labeled N-Boc-erythro-sphingosine.
|
-
- HY-W778270
-
|
|
|
2-Oxo clopidogrel- 13C,d3 hydrochloride is the deuterium and 13C-labeled (±)-2-Oxo clopidogrel hydrochloride (HY-W585947).
|
-
- HY-W779017
-
|
|
|
Thymidine- 13C5 (DThyd- 13C5; NSC 21548- 13C5) is 13C-labeled Thymidine (HY-N1150) .
|
-
- HY-Y0978S3
-
|
|
|
Boc-Glycine- 13C is a 13C-labeled Boc-Glycine (HY-Y0978). Boc-Glycine is a Glycine (HY-Y0966) derivative .
|
-
- HY-111095S3A
-
|
|
|
D-(-)-Lactic acid- 13C-2 (sodium) is a 13C-labeled D-(-)-Lactic acid (HY-111095). D-(-)-Lactic acid can be used for a variety of biochemical studies.
|
-
- HY-76204S
-
|
|
|
Glycine ethyl ester- 13C hydrochloride is a 13C-labeled Glycine ethyl ester hydrochloride (HY-76204). Glycine ethyl ester monohydrochloride is a Glycine (HY-Y0966) derivative .
|
-
- HY-W768527
-
|
|
|
Methyl piperidine-4-carboxylate hydrochloride- 13C3 is the 13C-labeled Methyl piperidine-4-carboxylate hydrochloride (HY-W002947).
|
-
- HY-W778772
-
|
|
|
Benz[a]anthracene-7-acetonitrile- 13C2 is the 13C-labeled Benz[a]anthracene-7-acetonitrile (HY-W742528).
|
-
- HY-Y0252S
-
|
|
|
L-Proline- 13C5 is the 13C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
|
-
- HY-N0486S2
-
|
|
|
Leucine- 13C6 is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .
|
-
- HY-N1981S
-
|
|
|
Triolein- 13C3 is the 13C-labeled Triolein. Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties .
|
-
- HY-N0717S6
-
|
|
|
L-Valine- 13C5 is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
|
-
- HY-B0434S
-
|
|
|
Ribavirin- 13C5 is the 13C-labeled Ribavirin. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV.
|
-
- HY-W013068S2
-
|
|
|
DMT-dT Phosphoramidite- 13C is 13C-labeled DMT-dT Phosphoramidite (HY-W013068). DMT-dT Phosphoramidite is typically used in the synthesis of DNA.
|
-
- HY-N0623S2
-
|
|
|
L-Tryptophan- 13C11 is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .
|
-
- HY-N0486S1
-
|
|
|
L-Leucine- 13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .
|
-
- HY-W769556
-
|
|
|
Ethyl Cyano(ethoxymethylene)acetate- 13C3 is the 13C-labeled (Z)-Ethyl 2-cyano-3-ethoxyacrylate (HY-W071513).
|
-
- HY-W009204S5
-
|
|
|
Fmoc-Ala-OH- 13C3 is a 13C-labeled Fmoc-Ala-OH (HY-W009204). Fmoc-Ala-OH is an alanine derivative .
|
-
- HY-W750001
-
|
|
|
1-Acetoxy-2,5-hexanedione- 13C4 is the 13C-labeled 1-Acetoxy-2,5-hexanedione
|
-
- HY-W014423S2
-
|
|
|
L-Histidine- 13C6 (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-N0473S4
-
|
|
|
L-Tyrosine- 13C is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
|
-
- HY-I1111S3
-
|
|
|
Fmoc-L-Val-OH- 13C5 is a 13C-labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .
|
-
- HY-N0326S5
-
|
|
|
L-Methionine- 13C5 is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-N0324S2
-
|
|
|
Cholic acid- 13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
|
-
- HY-W145482S1
-
|
|
|
3-O-Methyl-D-glucopyranose- 13C6 is 13C-labeled 3-O-Methyl-D-glucopyranose (HY-W145482) .
|
-
- HY-W748574
-
|
|
|
Sodium methanesulfonate- 13C is the 13C-labeled Sodium methanesulfonate (HY-W034344). Sodium methanesulfonate is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-N0473S3
-
|
|
|
L-Tyrosine- 13C9 is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
|
-
- HY-15651S
-
|
|
|
Alvelestat- 13C,d3 (AZD9668- 13C,d3) is 13C-labeled Alvelestat (HY-15651) .
|
-
- HY-113252S1
-
|
|
|
2-Methoxyestrone- 13C6 is the 13C-labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.
|
-
- HY-W768246
-
|
|
|
Galactose 1-phosphate- 13C6 potassium is the 13C-labeled Galactose 1-phosphate Potassium salt (HY-113143A). Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars.
|
-
- HY-N0091S2
-
|
|
|
Hypoxanthine- 13C5 is a 13C-labeled Hypoxanthine (HY-N0091). Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
|
-
- HY-W768275
-
|
|
|
Glucopyranose- 13C5 (D-Glucose-2,3,4,5,6- 13C5) is the 13C-labeled Glucopyranose (HY-W854449).
|
-
- HY-N0473S2
-
|
|
|
L-Tyrosine- 13C6 is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
|
-
- HY-W750987
-
|
|
|
Formaldehyde 2,4-Dinitrophenylhydrazone- 13C is the 13C-labeled 1-(2,4-Dinitrophenyl)-2-methylenehydrazine (HY-W290520).
|
-
- HY-N0326S4
-
|
|
|
L-Methionine-1- 13C is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-N0717S5
-
|
|
|
L-Valine-2- 13C is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
|
-
- HY-W777418
-
|
|
|
Isosorbide mononitrate- 13C6 (Isosorbide-5-mononitrate- 13C6) is 13C-labeled Isosorbide mononitrate (HY-B0642) .
|
-
- HY-N7092S22
-
|
|
|
D-Fructose- 13C3 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-W654109
-
|
|
|
2-Chloroanthracene- 13C6 (Anthracene, 2-chloro- 13C6) is the 13C-labeled 2-Chloroanthracene (HY-W014272).
|
-
- HY-N1394S
-
|
|
|
p-Anisic acid- 13C6 is the 13C-labeled p-Anisic acid. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties .
|
-
- HY-W765364
-
|
|
|
2,3-Dichlorobenzoic acid- 13C,d3 is the deuterium labeled and 13C-labeled 2,3-Dichlorobenzoic acid (HY-W012508).
|
-
- HY-128417S4
-
|
|
|
alpha-D-glucose- 13C6 is 13C-labeled alpha-D-glucose (HY-128417). alpha-D-glucose is an endogenous metabolite.
|
-
- HY-B0388S
-
|
|
|
Probucol- 13C3 is the 13C-labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
|
-
- HY-N0717S4
-
|
|
|
L-Valine-1- 13C is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
|
-
- HY-W777823
-
|
|
|
N-(a,a-Dimethylbenzyl)benzenesulfonamide- 13C6 is the 13C-labeled N-(2-Phenylpropan-2-yl)benzenesulfonamide (HY-W701611).
|
-
- HY-76204S1
-
|
|
|
Glycine ethyl ester- 13C2 hydrochloride is a 13C-labeled Glycine ethyl ester hydrochloride (HY-76204). Glycine ethyl ester monohydrochloride is a Glycine (HY-Y0966) derivative .
|
-
- HY-W750553
-
|
|
|
2-Ethylhexyl 2-cyanoacetate- 13C3 (Cyanoacetic Acid Octyl Ester- 13C3) is the 13C-labeled 2-Ethylhexyl 2-cyanoacetate.
|
-
- HY-W751110
-
|
|
|
N'-Nitro(methylsulfanyl)methanimidamide- 13C (N-Nitro-S-methylisothiourea- 13C) is the 13C-labeled N'-Nitro(methylsulfanyl)methanimidamide (HY-W673314).
|
-
- HY-W771036
-
|
|
|
Argininic acid- 13C6 (L-Argininic Acid- 13C6) is the 13C-labeled Argininic acid (HY-113079). Argininic acid is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-W748002
-
|
|
|
a-Methyl-2-piperidinemethanol- 13C2 is the 13C-labeled α-Methyl-2-piperidinemethanol (HY-W742168).
|
-
- HY-N0623S3
-
|
|
|
L-Tryptophan-1- 13C is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .
|
-
- HY-W750263
-
|
|
|
Pyruvic acid- 13C2 (Acetylformic acid- 13C2) is the 13C-labeled Pyruvic acid (HY-Y0781). Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
|
-
- HY-N7092S24
-
|
|
|
D-Fructose- 13C4 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-W771037
-
|
|
|
2-Oxoarginine- 13C6 (δ-Guanido-α-ketovaleric Acid- 13C6) is the 13C-labeled 2-Oxoarginine (HY-113417).
|
-
- HY-I1111S1
-
|
|
|
Fmoc-L-Val-OH-1- 13C is a 13C-labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .
|
-
- HY-40354S
-
|
|
|
Tofacitinib- 13C3 is the 13C-labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
|
-
- HY-W777751
-
|
|
|
6-Desamino 6-chloro etravirine- 13C3 is the 13C-labeled 6-Desamino 6-Chloro Etravirine (HY-W740641).
|
-
- HY-W767285
-
|
|
|
6-Amino-5-nitrosouracil- 13C2 is the 13C-labeled 6-Amino-5-nitrosouracil (HY-W053097).
|
-
- HY-W747290
-
|
|
|
Bis(methylsulfinylethyl)sulfone- 13C4 is the 13C-labeled 1-(Methylsulfinyl)-2-((2-(methylsulfinyl)ethyl)sulfonyl)ethane (HY-W713530).
|
-
- HY-W770176
-
|
|
|
2-Benzyl-5-chlorobenzaldehyde- 13C6 is the 13C-labeled 2-Benzyl-5-chlorobenzaldehyde (HY-W332685).
|
-
- HY-N0473S5
-
|
|
|
L-Tyrosine-4- 13C is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
|
-
- HY-B0945S
-
|
|
|
Nitromide- 13C6 (3,5-Dinitrobenzamide- 13C6) is the 13C-labeled Nitromide (HY-B0945). Nitromide is an anti-parasitic agent .
|
-
- HY-N0666S6
-
|
|
|
L-Aspartic acid-1,4- 13C2 is the 13C-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
|
-
- HY-W768211
-
|
|
|
2-Deoxy-2-fluoro-D-glucose- 13C6 is the 13C-labeled 2-Deoxy-2-fluoro-D-glucose.
|
-
- HY-B0318S
-
1 Publications Verification
|
|
Metronidazole- 13C2, 15N2 is the 13C-labeled and 15N-labeled Metronidazole. Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.
|
-
- HY-N0473S7
-
|
|
|
L-Tyrosine-1- 13C is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
|
-
- HY-N0684S3
-
|
|
|
Vitamin K1- 13C6 is the 13C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
|
-
- HY-Y0978S2
-
|
|
|
Boc-Glycine-2- 13C is a 13C-labeled Boc-Glycine (HY-Y0978). Boc-Glycine is a Glycine (HY-Y0966) derivative .
|
-
- HY-N0486S5
-
|
|
|
L-Leucine-2- 13C is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .
|
-
- HY-113357S
-
|
|
|
m-Coumaric acid- 13C3 is the 13C-labeled m-Coumaric acid. m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant.
|
-
- HY-W778771
-
|
|
|
Benz[a]anthracene-7-acetic Acid- 13C2 is the 13C-labeled 2-(Tetraphen-7-yl)acetic acid (HY-W704171).
|
-
- HY-W777862
-
|
|
|
1-Stearoyl-rac-glycerol- 13C3,d5 is the deuterium labeled and 13C-labeled 1-Stearoyl-rac-glycerol.
|
-
- HY-W753344
-
|
|
|
2-(2,6-Dichlorophenoxy)-N-phenylacetamide- 13C6 is the 13C-labeled 2-(2,6-Dichlorophenoxy)-N-phenylacetamide (HY-W713396).
|
-
- HY-W770721
-
|
|
|
Phenylboronic acid- 13C6 is the 13C-labeled Phenylboronic acid (HY-W001090). Phenylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-Y0479S
-
|
|
|
L-Lactic acid- 13C3 is a 13C-labeled L-Lactic acid (HY-Y0479). L-Lactic acid- 13C3 can be used for lactate metabolism research .
|
-
- HY-W777037
-
|
|
|
2,3-Dichlorobenzamidyl Guanidine- 13C2 is the 13C-labeled 2-(2,3-Dichlorobenzoyl)hydrazine-1-carboximidamide (HY-W727201).
|
-
- HY-N0382S
-
|
|
|
Galangin- 13C3 is the 13C-labeled Galangin. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.
|
-
- HY-13693S2
-
|
|
|
Mometasone furoate- 13C,d6 (Sch32088- 13C,d6) is 13C-labeled Mometasone furoate (HY-13693) .
|
-
- HY-W766920
-
|
|
|
Olsalazine disodium- 13C12 is the 13C-labeled Olsalazine disodium (HY-B0174). Olsalazine Disodium is an anti-inflammatory compound that works in inflammatory bowel disease and ulcerative colitis.
|
-
- HY-B0178AS
-
|
|
|
Guanidine- 13C, 15N3 (hydrochloride)is the 13C-labeled and 15N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins .
|
-
- HY-15097S
-
|
|
|
Myricetin- 13C3 is the 13C-labeled Myricetin. Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.
|
-
- HY-B2156S1
-
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|
|
Menaquinone-4- 13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
|
-
- HY-N6618S
-
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|
|
DL-Mannitol- 13C is the 13C-labeled DL-Mannitol. DL-Mannitol is obtained by combining D-mannitol with a sample of Lmannitol obtained by reduction of L-mannono-1, Clactone .
|
-
- HY-113283S
-
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|
|
Homogentisic acid- 13C6 is the 13C-labeled Homogentisic acid (HY-113283). Homogentisic acid is a specific metabolite that accumulates in the urine and serum. Homogentisic acid can be used for diagnosis of alkaptonuria. Homogentisic acid is a phenolic acid .
|
-
- HY-16637S3
-
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|
|
Folic acid- 13C5 is the 13C-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
|
-
- HY-W749742
-
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|
|
Isopropyltriphenylphosphonium bromide- 13C3 (Triphenyl(propan-2-yl)phosphonium bromide- 13C3) is the 13C-labeled Isopropyltriphenylphosphonium bromide (HY-W013757).
|
-
- HY-W778203
-
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|
|
Glycolic acid- 13C2 is the 13C-labeled Glycolic acid (HY-W015967). Glycolic acid- 13C2 is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
|
-
- HY-N0593S3
-
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|
|
Deoxycholic acid- 13C is the 13C-labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
|
-
- HY-N7092S23
-
|
|
|
D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-N0455AS7
-
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|
|
L-Arginine- 13C (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-N0473S6
-
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|
|
L-Tyrosine-3,5- 13C2 is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
|
-
- HY-W771025
-
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|
|
1,4-Diiodobutane- 13C4 (Tetramethylene Iodide (stabilized with Copper chip)- 13C4) is the 13C-labeled 1,4-Diiodobutane (HY-W004871).
|
-
- HY-B0456S
-
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|
|
Riboflavin- 13C4, 15N2is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-W778791
-
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|
|
N-Formylglycine ethyl ester- 13C2 is the 13C-labeled N-Formylglycine Ethyl Ester (HY-W141893). N-Formylglycine Ethyl Ester is a Glycine (HY-Y0966) derivative .
|
-
- HY-144343S
-
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|
|
(Rac)-cis-3-hydroxy glyburide- 13C,d3 is a 13C-labeled and deuterium labeled (Rac)-cis-3-hydroxy glyburide .
|
-
- HY-W778297
-
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|
|
5,6-Diamino-4-thiouracil- 13C2 is the 13C-labeled 5,6-Diamino-4-thiouracil (HY-W740396).
|
-
- HY-W392933S3
-
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|
|
Thymidine 5'-monophosphate- 13C10 (Thymidine-5'-phosphate- 13C10) dilithium is 13C-labeled Thymidine 5'-monophosphate (HY-W392933).
|
-
- HY-W024986S
-
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|
|
4-(4-Hexoxyphenyl)benzonitrile- 13C6 (4'-Hexyloxy-4-biphenylcarbonitrile- 13C6) is the 13C-labeled 4-(4-Hexoxyphenyl)benzonitrile.
|
-
- HY-N0391S3
-
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|
|
L-Citrulline- 13C is the 13C-labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
|
-
- HY-W000450S
-
|
|
|
5-Aminolevulinic acid- 13C is the 13C-labeled 5-Aminolevulinic acid. 5-Aminolevulinic acid (5-ALA) is a non-protein amino acid that plays a rate-limiting role in heme biosynthesis.
|
-
- HY-N0650S1
-
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|
|
L-Serine- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-W770294
-
|
|
|
3,4,5,6-Tetrabromophthalic acid- 13C6 (Tetrabromophthalic acid- 13C6) is the 13C-labeled 3,4,5,6-Tetrabromophthalic acid (HY-W259069).
|
-
- HY-B0892S
-
|
|
|
Benzyl alcohol-α- 13C-α,α-d2 is the 13C-labeled Benzyl alcohol. Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.
|
-
- HY-W778790
-
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|
|
Ethyl 2-formamido-3-hydroxyacrylate- 13C2 is the 13C-labeled Ethyl 2-formamido-3-hydroxyacrylate (HY-W704462).
|
-
- HY-N0666S1
-
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|
|
L-Aspartic acid- 13C4, 15N is the 13C-labeled and 15N-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
|
-
- HY-W751444
-
|
|
|
2,4-Dimethylanisole- 13C6 (4-Methoxy-m-xylene- 13C6) is the 13C-labeled 2,4-Dimethylanisole (HY-W100677).
|
-
- HY-W753343
-
|
|
|
2-Chloro-N-phenylacetamide- 13C6 (2-Chloroacetanilide- 13C6) is the 13C-labeled 2-Chloro-N-phenylacetamide (HY-W069522).
|
-
- HY-W018386S1
-
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|
|
3-Bromo-L-tyrosine- 13C9 (3-Bromo-Tyr- 13C9) is 13C-labeled 3-?Bromo-?L-?tyrosine (HY-W018386) .
|
-
- HY-I0960S
-
|
|
|
Uracil- 13C2, 15N2 is the 13C-labeled and 15N-labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
|
-
- HY-134178S1
-
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|
|
5-Fluorouridine 5'-triphosphate- 13C, 19F,d1 is deuterium and 13C-labeled 5-Fluorouridine 5'-triphosphate (HY-134178).
|
-
- HY-W015084S
-
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|
|
β-Ionone- 13C3 is the 13C-labeled β-Ionone. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .
|
-
- HY-W778171
-
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|
|
2-Benzyloxy-5-nitro-benzoic Acid Benzyl Ester- 13C6 is the 13C-labeled Benzyl 2-(benzyloxy)-5-nitrobenzoate (HY-W702473).
|
-
- HY-113400S1
-
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|
|
Cytidine diphosphate- 13C9 dilithium is 13C-labeled Cytidine diphosphate (HY-113400). Cytidine diphosphate is a nucleoside diphosphate that acts as a carrier for phosphorylcholine, diacylglycerol, and other molecules during phospholipid synthesis.
|
-
- HY-W770952
-
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|
|
DL-Phenylmercapturic Acid- 13C6 (N-Acetyl-S-phenyl-L-cysteine- 13C6) is the 13C-labeled DL-Phenylmercapturic Acid (HY-W141770). DL-Phenylmercapturic Acid is a cysteine derivative .
|
-
- HY-10285S1
-
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|
|
(rel)-Saxagliptin- 13C,d2 ((rel)-BMS-477118- 13C,d2) TFA is 13C-labeled Saxagliptin (HY-10285) .
|
-
- HY-115584S
-
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|
|
Lufenuron- 13C6 is a 13C-labeled Lufenuron. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods .
|
-
- HY-W777496
-
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|
|
Saccharin- 13C6 is the 13C-labeled Saccharin (HY-Y0272). Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties .
|
-
- HY-N0455AS6
-
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|
|
L-Arginine- 13C6 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-16271S
-
|
|
|
Kevetrin (hydrochloride)- 13C2, 15N3 is the 13C-labeled and 15N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
|
-
- HY-W754199
-
|
|
|
Glycocyamine- 13C (Guanidinoacetic acid- 13C) is the 13C-labeled Glycocyamine (HY-W021448). Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird.
|
-
- HY-N0384S3
-
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|
|
Homovanillic acid- 13C6, 18O is the 13C-labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
|
-
- HY-W778172
-
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|
|
2-Benzyloxy-3-nitro-benzoic Acid Benzyl Ester- 13C6 is the 13C-labeled Benzyl 2-(benzyloxy)-3-nitrobenzoate (HY-W702474).
|
-
- HY-18260S2
-
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|
|
Bisphenol A- 13C12 is the 13C-labeled Bisphenol A (HY-18260). Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-N0650S
-
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|
|
L-Serine- 13C3 is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-113251S1
-
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|
|
2-Hydroxyestrone- 13C6 is the 13C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic .
|
-
- HY-W017018S1
-
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|
|
L-Ornithine-1,2- 13C2 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
- HY-N0229S9
-
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|
|
L-Alanine- 13C2 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-W778716
-
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|
2-(1-Ethoxyethylidene)malononitrile- 13C2 (Propanedinitrile, 2-(1-ethoxyethylidene)- 13C2) is the 13C-labeled 2-(1-Ethoxyethylidene)malononitrile (HY-W008403).
|
-
- HY-W749665
-
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Clindamycin Hydrochloride- 13C,d3 is the deuterium and 13C-labeled Clindamycin hydrochloride (HY-B0408A). Clindamycin hydrochloride is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal.
|
-
- HY-W751099
-
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|
Corticosterone- 13C3 is a 13C-labeled corticosterone (HY-B1618). Corticosterone (17-Deoxycortisol) is an orally available glucocorticoid that can regulate limbic system neurons and has good immunosuppressive activity.
|
-
- HY-N0650S2
-
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L-Serine-1- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-W753497
-
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|
Benzene-1,2,4-tricarboxylic acid- 13C3 (Trimellitic Acid- 13C3) is the 13C-labeled Benzene-1,2,4-tricarboxylic acid (HY-W014409).
|
-
- HY-N0229S8
-
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L-Alanine- 13C3 is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-N0216S2
-
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Benzoic acid- 13C is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
|
-
- HY-144920S
-
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|
|
Tacrolimus impurity 16- 13C,d2 is the deuterium labeled and 13C-labeled 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506 (HY-W777541).
|
-
- HY-W654157
-
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Dicloxacillin- 13C4 sodium hydrate is the 13C-labeled Dicloxacillin Sodium hydrate (HY-B0977). Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-B2130S2
-
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Uric acid- 13C5 is the 13C-labeled Uric acid (HY-B2130). Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-W768574
-
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|
|
Bisphenol A Bissulfate Disodium Salt- 13C12 is the 13C-labeled Sodium S,S′-[(1-methylethylidene)di-4,1-phenylene] disulfate (2:1) (HY-W587516).
|
-
- HY-W012835S2
-
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4-Methylanisole- 13C is the 13C-labeled 4-Methylanisole. 4-Methylanisole (4-Methoxytoluene) is food flavoring agent and can be naturally found in Ylang Ylang fragrance oil .
|
-
- HY-N0455AS3
-
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|
L-Arginine-1- 13C (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-W749598
-
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|
|
N-Methoxy-N-methylnicotinamide- 13C6 (3-Pyridinecarboxamide, N-methoxy-N-methyl- 13C6) is the 13C-labeled N-methoxy-N-methylnicotinamide (HY-W051270).
|
-
- HY-N0356S
-
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(+/-)-Catechin Gallate- 13C3 is the 13C-labeled (-)-Catechin gallate. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
|
-
- HY-B1337S4
-
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Choline Chloride- 13C3 is the 13C-labeled Choline (chloride). Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.
|
-
- HY-N0650S4
-
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|
|
L-Serine-2- 13C is the 13C-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-Y0966S3
-
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|
|
Glycine- 13C2 is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-W042357S4
-
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|
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Ac-rC Phosphoramidite- 13C9 is 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
|
-
- HY-W752253
-
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|
|
N-2-Naphthalenyl-N-phenyl-2-naphthalenamine- 13C6 is the 13C-labeled N-2-Naphthalenyl-N-phenyl-2-naphthalenamine.
|
-
- HY-W777534
-
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|
4-Acetamidobenzene-1-sulfonyl chloride- 13C6 (N-Acetylsulfanilyl chloride- 13C6) is the 13C-labeled 4-Acetamidobenzene-1-sulfonyl chloride (HY-W012207).
|
-
- HY-W016498S1
-
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|
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Paraxanthine- 13C4, 15N3 is the 13C-labeled and 15N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
|
-
- HY-N0216S1
-
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|
|
Benzoic acid- 13C6 is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
|
-
- HY-N0229S7
-
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|
|
L-Alanine-2- 13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-Y1250S3
-
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|
|
Fmoc-Gly-OH- 13C is a 13C-labeled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .
|
-
- HY-Y0966S2
-
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|
|
Glycine-2- 13C is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-N0470S2
-
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|
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L-Lysine- 13C (dihydrochloride) is the 13C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
|
-
- HY-W780162
-
|
|
|
4-Methoxy-4-oxobutanoic acid- 13C4 (Succinic Acid Monomethyl Ester- 13C4) is the 13C-labeled 4-Methoxy-4-oxobutanoic acid (HY-W010380).
|
-
- HY-N0229S6
-
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|
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L-Alanine-3- 13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-W338810S
-
|
|
|
S-(5'-Adenosyl)-L-methionine- 13C5 sulfate is a 13C-labeled S-(5'-Adenosyl)-L-methionine. S-(5'-Adenosyl)-L-methionine is a methyl donor and cofactor .
|
-
- HY-N0187S
-
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|
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4-Methylumbelliferone- 13C4 (Hymecromone- 13C4) is the 13C-labeled 4-Methylumbelliferone (HY-N0187). 4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects.
|
-
- HY-W393970S2
-
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|
|
2′-Deoxyguanosine 5′-monophosphate- 13C10 (5'-Deoxyguanylic acid- 13C10) dilithium is 13C-labeled 2′-Deoxyguanosine 5′-monophosphate (HY-W393970).
|
-
- HY-N0229S1
-
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L-Alanine-1- 13C is the 13C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-W143131S
-
|
|
|
Diethyl itaconate,98% (stabilized with TBC)- 13C5 (Itaconic Acid Diethyl Ester (stabilized with TBC)- 13C5) is the 13C-labeled Diethyl itaconate,98% (stabilized with TBC) (HY-W143131).
|
-
- HY-Y0966S4
-
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|
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Glycine-1- 13C is the 13C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
|
-
- HY-W754303
-
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|
|
Dihydroartemisinin- 13C,d5 (Dihydroqinghaosu- 13C,d5) is the deuterium labeled and 13C-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is a potent anti-malaria agent.
|
-
- HY-17563S2
-
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|
2'-Deoxyguanosine- 13C10 (Deoxyguanosine- 13C10; Guanine deoxyriboside- 13C10) is 13C-labeled 2'-Deoxyguanosine (HY-17563). 2'-Deoxyguanosine (Deoxyguanosine) is deoxyguanosine.
|
-
- HY-W776973
-
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|
|
Glycidamide- 13C3 (Oxiranecarboxamide- 13C3) is the 13C-labeled Glycidamide (HY-119329). Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects .
|
-
- HY-W777439
-
|
|
|
4-Chloro-6-nitrosoresorcinol- 13C6 is the 13C-labeled 4-Chloro-6-nitrosobenzene-1,3-diol (HY-W699627).
|
-
- HY-W766785
-
|
|
|
Tiamulin Fumarate- 13C4 is the 13C-labeled Tiamulin. Tiamulin (Thiamutilin) fumarate is a diterpenic antibiotic that is widely used in pigs and poultry for the control of infectious diseases. Tiamulin fumarate is effectively used in the study of airsacculitis, which is primarily caused by Mycoplasma spp .
|
-
- HY-N0683S
-
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|
|
α-Vitamin E- 13C6 is the 13C-labeled α-Vitamin E. α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant .
|
-
- HY-W134007S1
-
3 Publications Verification
|
|
Hexadecanoate- 13C16 (potassium) is the 13C-labeled Hexadecanoate sodium. Hexadecanoate potassium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
|
-
- HY-N0469S1
-
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L-Lysine- 13C6 (dihydrochloride) is the 13C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions .
|
-
- HY-W756750
-
|
|
|
2-Acetyl-3-oxobutane-1,4-diyl diacetate- 13C4 is the 13C-labeled 2-Acetyl-3-oxobutane-1,4-diyl diacetate.
|
-
- HY-W040047S
-
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|
|
Pregnanediol 3-glucuronide- 13C5 is 13C-labeled Pregnanediol (HY-107850) Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo.
|
-
- HY-W017018S2
-
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|
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L-Ornithine-1,2,3,4,5- 13C5 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
|
-
- HY-128417S5
-
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|
|
alpha-D-glucose- 13C6,d7 is deuterium and 13C-labeled alpha-D-glucose (HY-128417). alpha-D-glucose is an endogenous metabolite.
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-
- HY-113225S2
-
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Guanosine triphosphate- 13C (GTP- 13C) dilithium is 13C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
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-
- HY-B0289S
-
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Erdosteine- 13C4 is a 13C-labeled Erdosteine. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation . Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects .
|
-
- HY-W747332
-
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Pyruvic aldehyde (42% in water)- 13C3 is the 13C-labeled Pyruvic aldehyde (42% in water) (HY-W020014). Pyruvic aldehyde (42% in water) is often used as a reagent in organic synthesis, as a flavoring agent, and in tanning.
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-
- HY-N0455AS5
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L-Arginine-1,2- 13C2 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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-
- HY-79096S
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BOC-L-Phenylalanine- 13C is a 13C-labeled BOC-L-Phenylalanine (HY-79096). Boc-L-phenylalanine is a Boc-protected L-phenylalanine that can be used in the synthesis of other active compounds. Boc-L-phenylalanine is also a capping agent .
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-
- HY-N1132AS2
-
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Alpha,Beta-Trehalose- 13C12 is the 13C-labeled D-(+)-Trehalose dihydrate (HY-N1132A). D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.
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-
- HY-W777836
-
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2,2-Dibromomalonamide- 13C3 (Dibromo Malonamide- 13C3) is the 13C-labeled 2,2-Dibromomalonamide (HY-W324382). 2,2-Dibromomalonamide is a biochemical agent .
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-
- HY-114293S
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Acetyl coenzyme A- 13C2 lithium is the 13C-labeled Acetyl coenzyme A (HY-114293). Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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-
- HY-N0683S1
-
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α-Vitamin E- 13C3 is the 13C-labeled α-Vitamin E. α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant .
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-
- HY-W777351
-
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Etravirine- 13C3 (R165335- 13C3) is the 13C-labeled Etravirine (HY-90005). Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
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-
- HY-W739894S
-
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Diclofenac metabolite- 13C6 is the 13C-labeled 1-(2,6-Dichloro-4-hydroxphenyl)-1,3-dihydroindol-2-one (HY-W739894).
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-
- HY-W018241S
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2,2'-Sulfonyldiethanol(65% in water)- 13C4 (2,2-Sulfonyldiethanol- 13C4) is the 13C-labeled 2,2'-Sulfonyldiethanol(65% in water) (HY-W018241).
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-
- HY-W010382S
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Oxaloacetic acid- 13C4 is the 13C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis .
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-
- HY-112675S
-
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4-Octyl itaconate- 13C5-1 is 13C-labeled 4-Octyl itaconate (HY-112675). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
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-
- HY-Y0479S3
-
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L-Lactic acid-2- 13C1 is the 13C-labeled L-Lactic acid (HY-Y0479). L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid .
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-
- HY-Y1250S5
-
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Fmoc-Gly-OH- 13C2 is a 13C-labeled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .
|
-
- HY-W777833
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Ethyl 2-(6-nitro-2,3-dichlorobenzyl)glycine- 13C2 is the 13C-labeled Ethyl (2,3-dichloro-6-nitrobenzyl)glycinate (HY-W701652).
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-
- HY-B0167S1
-
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Salicylic acid- 13C6 is the 13C-labeled Salicylic acid (HY-B0167). Salicylic acid is a precursor to and a metabolite of Aspirin (HY-14654), can inhibit cyclo-oxygenase-2 (COX-2) activity .
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-
- HY-Y1250S4
-
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Fmoc-Gly-OH-1- 13C is a 13C-labeled Fmoc-Gly-OH (HY-Y1250). Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .
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-
- HY-B0315S
-
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Vitamin B12- 13C7 is the 13C-labeled Vitamin B12. Vitamin B12 is a vitamin. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood .
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-
- HY-15407AS
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Sacubitril- 13C4 (hemicalcium salt) is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696 .
|
-
- HY-W766332
-
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7-Hydroxy coumarin glucuronide sodium- 13C6 is the 13C-labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
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-
- HY-N0060S1
-
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Ferulic acid- 13C3 is the 13C-labeled Ferulic acid. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.
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-
- HY-16637S2
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(Rac)-Folic acid- 13C5, 15N is the 13C-labeled and 15N-labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
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-
- HY-B0122SS1
-
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|
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Topiramate- 13C6-1 (McN 4853- 13C6-1; RWJ 17021- 13C6-1) is 13C-labeled Topiramate (HY-B0122) .
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-
- HY-W042357S5
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Ac-rC Phosphoramidite- 13C,d1 is deuterium and 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
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-
- HY-N1393S
-
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2-Methoxybenzoic acid- 13C6 is the 13C-labeled 2-Methoxybenzoic acid. 2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.
|
-
- HY-W768912
-
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|
|
Paclitaxel- 13C6 is the 13C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy .
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-
- HY-W770183
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Uric acid- 13C3 is 13C-labeled Uric acid (HY-B2130). Uric acid is the end product of purine metabolism in the human body. Uric acid can scavenge reactive oxygen species (ROS), such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation.
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-
- HY-W020044S
-
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DL-alpha-Tocopherol- 13C3 is the 13C-labeled DL-alpha-Tocopherol. DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB .
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-
- HY-B0456S1
-
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Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
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-
- HY-W017401S
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Benzisothiazolinone-13C5 (1,2-Benzothiazol-3-one-13C5) is a 13C-labeled Benzisothiazolinone. Benzisothiazolinone is widely used as an antiseptic and antibacterial agent .
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-
- HY-W768295
-
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D-Lactose monohydrate- 13C6 is the 13C-labeled D-Lactose (hydrate) (HY-W115740). D-Lactose monohydrate is a type of lactose. D-Lactose is composed of D-galactose and D-glucose. D-Lactose monohydrate can be used as sweetener or excipient .
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-
- HY-W747213
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Diethyl 2-hydroxy-3-methylsuccinate- 13C (MALIC ACID, 3-METHYL-, DIETHYL ESTER- 13C) is the 13C-labeled Diethyl 2-hydroxy-3-methylsuccinate (HY-W502469).
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-
- HY-W779800
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D-α-Hydroxyglutaric acid- 13C5 disodium is the 13C-labeled D-α-Hydroxyglutaric acid (HY-113038). Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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-
- HY-100760S
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Toxoflavin- 13C4 is the 13C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity . Antibiotic properties.
|
-
- HY-W769319
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Inosinic acid- 13C5 (5'-IMP- 13C5) is the 13C-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs .
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-
- HY-B0859S
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MCPA- 13C8 is the 13C-labeled MCPA. MCPA is a phenoxy herbicide, and widely used to control annual and perennial broad leaved weeds, including poppy, thistles and docks, in crops such as cereals, rice, linseed, flax, grassland and turf .
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-
- HY-113225S5
-
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Guanosine triphosphate- 13C10 (GTP- 13C10) dilithium is 13C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
|
-
- HY-W749378
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1,2,3,4,5-Pentabromo-6-ethylbenzene- 13C6 is the 13C-labeled 1,2,3,4,5-Pentabromo-6-ethylbenzene (HY-W715201).
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-
- HY-15398S1
-
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Vitamin D3- 13C3 is the 13C-labeled Vitamin D3. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.
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-
- HY-W769734
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N-Acetylneuraminic Acid- 13C,d3 (N-Acetyl-β-D-neuraminic acid- 13C,d3) is the deuterium labeled and 13C-labeled N-Acetyl-β-D-neuraminic acid (HY-75278).
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-
- HY-W768296
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D-Lactose monohydrate- 13C12 is the 13C-labeled D-Lactose (hydrate) (HY-W115740). D-Lactose monohydrate is a type of lactose. D-Lactose is composed of D-galactose and D-glucose. D-Lactose monohydrate can be used as sweetener or excipient .
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-
- HY-W654084
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24 Bisphenol S- 13C12 is the 13C-labeled 2,4'-Dihydroxydiphenyl sulfone (HY-W128222). 2,4'-Dihydroxydiphenyl sulfone is an active small molecule and can be used as fire-resistant polyester compositions .
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-
- HY-W048482S2
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rU Phosphoramidite- 13C9 (DMT-2'O-TBDMS-rU phosphoramidite- 13C9) is 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
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-
- HY-W777477
-
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Homovanillic Acid- 13C6 (Vanilacetic acid- 13C6) is the 13C-labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
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-
- HY-W753370
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2,4,5-Trichloronitrobenzene- 13C6 (Benzene, 1,2,4-trichloro-5-nitro- 13C6) is the 13C-labeled 2,4,5-Trichloronitrobenzene (HY-W142633).
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-
- HY-167906S
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Hexadecyl 2-((4-Nitrophenyl)thio)acetate- 13C2 is the 13C-labeled Lunamarine (HY-167906). Lunamarine is a inhibitor of PDE5 with BBB permeability. Lunamarine can be used in the reseach of Pulmonary Arterial Hypertension (PAH) and Erectile Dysfunction (ED) .
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-
- HY-W777546
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(5-Formylfuran-2-yl)methyl acetate- 13C6 (Acetic Acid 5-Formylfurfuryl Ester- 13C6) is the 13C-labeled (5-Formylfuran-2-yl)methyl acetate (HY-W111899).
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- HY-Y0313S1
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p-Hydroxybenzaldehyde- 13C is the 13C-labeled p-Hydroxybenzaldehyde. p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
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- HY-I0626S
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Cytosine- 13C2, 15N3 is the 13C-labeled and 15N-labeled Cytosine. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging .
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-
- HY-W768324
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Ribitol- 13C5 (Adonitol- 13C5) is the 13C-labeled Ribitol (HY-100582). Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol.
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-
- HY-W778655
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Desmethylene oxobexarotene methyl ester- 13C4 is the 13C-labeled Methyl 4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzoate (HY-W130051).
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- HY-B0202S4
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Irbesartan- 13C,d4 (SR-47436- 13C,d4; BMS-186295- 13C,d4) is 13C-labeled Irbesartan (HY-B0202) .
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-
- HY-14608S
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L-Glutamic acid- 13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
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-
- HY-B0891S1
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17α-Hydroxyprogesterone- 13C3 is the 13C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
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-
- HY-D0187S4
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L-Glutathione reduced- 13C (GSH- 13C; γ-L-Glutamyl-L-cysteinyl-glycine- 13C) is 13C-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced is an endogenous antioxidant and oxygen free radical scavenger.
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- HY-N6625S
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Chlorothalonil- 13C2 is the 13C-labeled Chlorothalonil. Chlorothalonil is a broad spectrum fungicide and is effective in protecting plants against fungal diseases caused mainly by Phytophthora infestans and Alternaria solani. Chlorothalonil is used for controlling of fungal foliar diseases of vegetables and crops .
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- HY-B2039S
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Bentazone- 13C10, 15N is the 13C-labeled and 15N-labeled Bentazone. Bentazone is a post-emergence herbicide used for selective control of broadleaf weeds and sedges in beans, rice, corn, peanuts, mint and others. It acts by interfering with photosynthesis .
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-
- HY-W777806
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Pyrimido[1,2-a]purin-10(1H)-one- 13C3 is the 13C-labeled Pyrimido[1,2-a]purin-10(3H)-one (HY-W701574).
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- HY-18341S1
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Thyroxine hydrochloride- 13C6 is the 13C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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-
- HY-W768181
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1,5-Anhydrosorbitol- 13C6 (1,5-Anhydro-D-glucitol- 13C6) is the 13C-labeled 1,5-Anhydrosorbitol (HY-113075). 1,5-Anhydrosorbitol is a short-term marker for glycemic control.
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- HY-B0141S4
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Estradiol- 13C6 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
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- HY-124489S
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2-Hydroxyestradiol- 13C6 is the 13C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .
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- HY-W018386S
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3-?Bromo-?L-?tyrosine- 13C6 (3-Bromo-Tyr- 13C6) is a 13C-labeled 3-?Bromo-?L-?tyrosine (HY-W018386). 3- Bromo- L- tyrosine (3-Bromo-Tyr) is a tyrosine derivative .
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- HY-W007527S
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4-Bromo-2-chlorophenol- 13C6 (4-Bromo-2-Chloro Phenol- 13C6) is the 13C-labeled 4-Bromo-2-chlorophenol (HY-W007527).
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- HY-B0234S
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Estrone- 13C3 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells .
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- HY-W754548
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Glycocholic acid- 13C2,d4 is the deuterium labeled and 13C-labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways .
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- HY-Y1055S4
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Guanine- 13C5 is 13C-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-W015913S
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Sodium 2-oxopropanoate- 13C3 is the 13C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .
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- HY-B1776AS1
-
1 Publications Verification
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Spermidine- 13C4 (hydrochloride) is the 13C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .
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- HY-14608S5
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L-Glutamic acid- 13C5 is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
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-
- HY-10999S1
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Trametinib- 13C6 is the 13C-labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis .
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- HY-N0092S4
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Inosine-13C3 is a 13C-labeled Inosine that can be used in pharmacokinetic studies of Inosine. Inosine is an agonist of adenosine receptors A1R and A2AR with anti-inflammatory immunomodulatory, antinociceptive and neuroprotective effects .
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-
- HY-W768220
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D-Fructose-1,2- 13C2 is the 13C-labeled D-Fructose. D-Fructose (D(-)-Fructose) is a monosaccharide found in honey, fruits, and?other?plants. Two D-Fructose molecules can combine to form a disaccharide, sucrose .
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- HY-W042357S3
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Ac-rC Phosphoramidite- 13C2,d1 is deuterium and 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
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- HY-N0229S
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L-Alanine-2- 13C, 15Nis the 13C-labeled and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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- HY-B0141S5
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Estradiol- 13C2 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
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- HY-B0234S3
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Estrone- 13C2 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells .
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- HY-W777340
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Gimeracil- 13C3 (Gimestat- 13C3) is the 13C-labeled Gimeracil (HY-17469). Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD) .
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-
- HY-W778257
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2-Amino-4,6-dichloropyrimidine- 13C2 (4,6-dichloropyrimidin-2-ylamine- 13C2) is the 13C-labeled 2-Amino-4,6-dichloropyrimidine (HY-41261).
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- HY-B0216S2
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Ethynyl Estradiol- 13C2 is the 13C-labeled Ethynyl Estradiol. Ethynyl Estradiol-13C2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-15398S4
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Vitamin D3- 13C5 is the 13C-labeled Vitamin D3 (HY-15398). Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells .
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-
- HY-143687S
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3-Cyano Gimeracil methyl ether- 13C3 is the 13C-labeled 5-Chloro-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile (HY-W050667).
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- HY-B0150S2
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Nicotinamide- 13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
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- HY-W778002
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(S)-(+)-Ketoprofen- 13C,d3 is the deuterium and 13C-labeled S-(+)-Ketoprofen (HY-B2137). S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
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- HY-W768856
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Artemether- 13C,d3 (Dihydroqinghaosu methyl ether- 13C,d3) is the deuterium and 13C-labeled Artemether (HY-N0402). Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .
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- HY-W747264
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P-Hydroxybenzaldehyde- 13C6 is the 13C-labeled p-Hydroxybenzaldehyde (HY-Y0313). p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
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- HY-B0574S2
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Mefenamic acid- 13C6 is the 13C-labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
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- HY-B2236S1
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DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is 13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
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- HY-N0682S3
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Pyridoxine- 13C4 (hydrochloride) is the 13C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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- HY-10572S1
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Efavirenz- 13C6 is the 13C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .
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- HY-W778162
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Phenanthrene- 13C2 is the 13C-labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
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- HY-14608S6
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L-Glutamic acid-5- 13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
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- HY-N0325S
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DL-Methionine- 13C is the 13C-labeled DL-Methionine. DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants .
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- HY-W751537
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4-[[(4-Fluorophenyl)imino]methyl]phenol- 13C6 (4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol- 13C6) is the 13C-labeled 4-[[(4-Fluorophenyl)imino]methyl]phenol (HY-W014178).
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- HY-W016814S
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(Z)-Aconitic acid- 13C6 is the 13C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
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- HY-W127578S1
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Glycidyl palmitate- 13C16 (Oxiran-2-ylmethyl palmitate- 13C16) is the 13C-labeled Glycidyl palmitate (HY-W127578). Glycidyl Palmitate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W777002
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Famotidine- 13C3 (MK-208- 13C3) is the 13C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
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- HY-W128417S
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4-(Dimethylamino)phenacyl bromide- 13C2,d6 (DmPABr- 13C2,d6) is 13C-labeled 4-(Dimethylamino)phenacyl bromide (HY-W128417) .
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- HY-14608S1
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L-Glutamic acid-1- 13C is the 13C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
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- HY-N0067S3
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γ-Aminobutyric acid- 13C4 is the 13C-labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain , binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors) .
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- HY-W008253S3
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5-Hydroxyindole-3-acetic acid- 13C6 is the 13C-labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
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- HY-W778023
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(R)-2-(3-Benzoylphenyl)propanoic acid- 13C,d3 ((R)-(-)-Ketoprofen- 13C,d3) is the deuterium labeled and 13C-labeled Ketoprofen-d3-1 (HY-W322573S).
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- HY-N7091S1
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Atrazine- 13C3, 15N3 is the 13C-labeled and 15N-labeled Atrazine. Atrazine is principally used for control of certain annual broadleaf and grass weeds. Atrazine inhibits photophosphorylation but typically does not result in lethality or permanent cell damage in the short term .
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- HY-50723S
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3-Methylxanthine- 13C4, 15N3 is the 13C-labeled and 15N-labeled 3-Methylxanthine. 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
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- HY-113128S
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sn-Glycerol 3-phosphate- 13C3 disodium is the 13C-labeled sn-Glycerol 3-phosphate disodium. sn-Glycerol 3-phosphate disodium is produced by cytosolic glycerol 3-phosphate dehydrogenase pathway through the reduction of dihydroxyacetone phosphate using NADH formed during glycolysis .
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- HY-W750399
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4,5,6,7-Tetrabromoisobenzofuran-1,3-dione- 13C6 (Tetrabromophthalic anhydride- 13C6) is the 13C-labeled 4,5,6,7-Tetrabromoisobenzofuran-1,3-dione (HY-W010833).
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- HY-Y0337S4
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L-Cysteine- 13C3 is the 13C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .
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- HY-W777440
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4-Chloro resorcinol- 13C6 is the 13C-labeled 4-Chlororesorcinol (HY-W015658). 4-Chlorobenzene-1,3-diol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W752476
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Succinyladenosine- 13C4 (N6-Succinyl adenosine- 13C4) is the 13C-labeled Succinyladenosine (HY-113284). Succinyladenosine, the metabolic product of dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase, is a biochemical marker of adenylosuccinase (ASL) deficiency .
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- HY-113359AS1
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Uridine 5'-diphosphate- 13C9 dilithium is 13C-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.
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- HY-W779404
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Ribavirin- 13C2 (Ribasphere- 13C2) is the 13C-labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
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- HY-W777329
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(4E)-4-Octenedioic acid- 13C2 ((E)-Oct-4-ene-1,8-dioic acid- 13C2) is the 13C-labeled (4E)-4-Octenedioic acid (HY-W151203).
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- HY-N0390S1
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3 Publications Verification
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L-Glutamine- 13C5 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .
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- HY-B0843S
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Metalaxyl- 13C6 is the 13C-labeled Metalaxyl. Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s=0.3-3.9 μg/mL).
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- HY-Y0337S2
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L-Cysteine-3- 13C is the 13C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .
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- HY-W014993S
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1,3-Dimethyluric acid- 13C4, 15N3 is the 13C-labeled and 15N-labeled 1,3-Dimethyluric acid. 1,3-Dimethyluric acid is a product of theophylline metabolism in man. 1,3-Dimethyluric acid is one of the purine components in urinary calculi.
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- HY-W778236
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Norflurazon- 13C,d3 (SAN 9789- 13C,d3) is the deuterium and 13C-labeled Norflurazon (HY-114849). Norflurazon (SAN 9789) is a bleaching herbicide. Norflurazon can block carotenoid biosynthesis by inhibiting phytoene desaturase activity .
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- HY-W767035
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O6-Benzyl-N2,3-etheno Guanosine- 13C2,d1 is the deuterium labeled and 13C-labeled O6-Benzyl-N2,3-etheno Guanosine.
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- HY-Y0337S3
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L-Cysteine-1- 13C is the 13C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .
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- HY-41121S1
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Boc-L-Ala-OH-3- 13C is a 13C-labeled Boc-L-Ala-OH (HY-41121). Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .
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- HY-41121S2
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Boc-L-Ala-OH-2- 13C is a 13C-labeled Boc-L-Ala-OH (HY-41121). Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .
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- HY-N0830S10
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Palmitic acid- 13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
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- HY-W777266
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Cyclohexane-1,3-dione- 13C3 is the 13C-labeled Cyclohexane-1,3-dione (HY-W007466). Cyclohexane-1,3-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-N0390S4
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L-Glutamine-5- 13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .
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- HY-D0184S5
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2'-Deoxycytidine- 13C9 (Deoxycytidine- 13C9; Cytosine deoxyriboside- 13C9; Deoxyribose cytidine- 13C9) is 13C-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
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- HY-W766699
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6-Amino-4-hydroxy-2-mercaptopyrimidine- 13C (6-Amino-2-thiouracil Monohydrate- 13C) is the 13C-labeled 6-Amino-4-hydroxy-2-mercaptopyrimidine (HY-75601).
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- HY-B0351S1
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Taurine- 13C2 is the 13C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes .
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- HY-W654362
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(R)-2-Thioxothiazolidine-4-carboxylic acid- 13C3 is the 13C-labeled (R)-2-Thioxothiazolidine-4-carboxylic acid. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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- HY-N0830S6
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3 Publications Verification
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Palmitic acid- 13C16 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
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- HY-N0830BS1
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3 Publications Verification
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Palmitic acid- 13C16 sodium is the 13C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
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- HY-N0390S5
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1 Publications Verification
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L-Glutamine-1- 13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .
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- HY-13632S1
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Exemestane- 13C3 is the 13C-labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .
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- HY-14749AS1
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Pyronaridine tetraphosphate- 13C2,d4 is the deuterium and 13C-labeled Pyronaridine tetraphosphate (HY-14749A). Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection .
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- HY-176145S
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N-Benzyl-2-iodo-N-(prop-2-yn-1-yl)acetamide- 13C is the 13C-labeled N-Benzyl-2-iodo-N-(prop-2-yn-1-yl)acetamide.
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- HY-111095S1
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D-(-)-Lactic acid-13C ((R)-2-Hydroxypropionic acid-13C) is a 13C-labeled D-Lactic acid. D-(-)-Lactic acid-13C can be used as an internal standard and can also be used in studies such as metabolic tracing.
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- HY-N0390S11
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L-Glutamine-2- 13C is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .
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- HY-N0464S
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Quinic acid- 13C3 is the 13C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid scavenges hydrogen peroxide (IC50=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC50 =93.75 μg/mL). D-(-)-Quinic acid is orally active .
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- HY-W750144
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Phenylglyoxylic acid- 13C8 (Benzoylformic acid- 13C8) is the 13C-labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds .
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- HY-144344S
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Benzyl(2R)-3-N,N-dibenzylamino-2-fluoropropanoate- 13C3 is a 13C-labeled and deuterium labeled Benzyl(2R)-3-N,N-dibenzylamino-2-fluoropropanoate .
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- HY-17461S
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Cortisone- 13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .
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- HY-W777928
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Cyclohexane-1,3-dione- 13C6 is the 13C-labeled Cyclohexane-1,3-dione (HY-W007466). Cyclohexane-1,3-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-N0830BS
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Palmitic acid- 13C (sodium) is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
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- HY-W767936
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Moxonidine- 13C,d3 (BDF5895- 13C,d3) is the 13C-labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.
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- HY-W780166
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Uric acid- 13C is the 13C-labeled Uric acid (HY-B2130). Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .
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- HY-W770914
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Stearoyl-L-carnitine chloride- 13C3 is the 13C-labeled Stearoyl-L-carnitine chloride (HY-130466). Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM .
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- HY-N0830S3
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Palmitic acid-1- 13C is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
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- HY-19528S1
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SAH- 13C5 is the 13C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .
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- HY-B1395S1
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Mecamylamine (hydrochloride)- 13C4, 15N is the 13C-labeled and 15N-labeled Mecamylamine hydrochloride. Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier .
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- HY-79576S2
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Estrone 3-methyl ether- 13C6 is a 13C-labeled Estrone 3-methyl ether (HY-79576). Estrone 3-methyl ether (Oestrone methyl ether; 3-O-Methylestrone) is a synthetic intermediate useful for synthesis of estrogen receptor modulator .
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- HY-W754982
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N-Cyclohexyl-1,3-benzothiazol-2-amine- 13C6 (N-Cyclohexylbenzothiazole-2-amine- 13C6) is the 13C-labeled N-Cyclohexyl-1,3-benzothiazol-2-amine (HY-W200757).
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- HY-Y0479AS2
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L-Lactate- 13C ((S)-2-Hydroxypropanoic acid- 13C) sodium is the 13C-labeled L-Lactic acid sodium (HY-W040233). L-lactate Sodium is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity .
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- HY-W768333
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D-Ribofuranose- 13C5 (D-Ribose- 13C5) is the 13C-labeled D-Ribofuranose (HY-113375). D-Ribofuranose (D-Ribose) is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Ribose 5 Phosphate Isomerase Deficiency and Medium Chain Acyl Co A Dehydrogenase Deficiency .
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- HY-10065S
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Axitinib- 13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50 values of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively .
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- HY-N0390S10
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L-Glutamine-1,2- 13C2 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .
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- HY-W749528
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3-Deoxyglucosone- 13C6 is the 13C-labeled (5s,6r)-2,5-dihydroxy-6-(hydroxymethyl)dihydro-2h-pyran-3(4h)-one (HY-W759076).
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- HY-I0096S
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Indole-2-carboxylic acid- 13C is the 13C-labeled Indole-2-carboxylic acid. Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current .
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- HY-W756637
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Ibufenac- 13C6 (Dytransin- 13C6) is the 13C-labeled Ibufenac (HY-W040672). Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .
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- HY-B0150S1
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Nicotinamide- 15N, 13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
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- HY-W750064
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Acetophenone- 13C8 (1-Phenylethan-1-One- 13C8) is the 13C-labeled Acetophenone (HY-Y0989). Acetophenone (1-Phenylethan-1-One) is an organic compound with simple structure. Acetophenone can be bioreduced to phenylethanol (PEA) .
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- HY-17376S3
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Ezetimibe- 13C6 (SCH 58235- 13C6) is the 13C-labeled Ezetimibe (HY-17376). Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
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- HY-141578S
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C18:1-Ceramide- 13C18 is a 13C-labeled C18:1-Ceramide (HY-141578). C18:1-Ceramide is a ceramide subspecies. C18:1-Ceramide can be used in the study of type 2 diabetes .
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- HY-W759459
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Meldrum's acid- 13C3 (2,2-Dimethyl-1,3-dioxane-4,6-dione- 13C3) is the 13C-labeled Meldrum's acid (HY-Y0232). Meldrum's acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W771024
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Butane-1,4-diyl bis(4-methylbenzenesulfonate)- 13C4 (4-(4-Methylphenyl)sulfonyloxybutyl 4-methylbenzenesulfonate- 13C4) is the 13C-labeled Butane-1,4-diyl bis(4-methylbenzenesulfonate) (HY-Z1250).
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- HY-B0495S4
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Lamotrigine- 13C3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .
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- HY-B2130S
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Uric acid- 13C, 15N3 is the 13C-labeled and 15N-labeled Uric acid. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .
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- HY-W334800S2
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(2S,6S)-2,6-Diaminoheptanedioic acid- 13C7 (L-threo-2,6-Diaminopimelic acid- 13C7) is 13C-labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).
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- HY-113046S
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5-Methyltetrahydrofolic acid- 13C5 is the 13C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid .
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- HY-32351AS1
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Calcifediol- 13C5 monohydrate is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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- HY-W768207
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Cytidine-1',2',3',4',5'- 13C5 is the 13C-labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .
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- HY-W779969
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2-Acetyl-4-tetrahydroxybutyl imidazole- 13C6 is the 13C-labeled 2-Acetyl-4-tetrahydroxybutyl imidazole (HY-14113). 2-Acetyl-5-tetrahydroxybutyl imidazole is a potent sphingosine-1-phosphate (S1P) lyase inhibitor in vivo.
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- HY-W749377
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1,2,3,4,5-Pentabromo-6-methylbenzene- 13C6 (Toluene, 2,3,4,5,6-pentabromo- 13C6) is the 13C-labeled 1,2,3,4,5-Pentabromo-6-methylbenzene (HY-W274110).
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- HY-90009AS1
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Tadalafil- 13C2,d3-1 (IC-351- 13C2,d3-1) is the deuterium and 13C-labeled Tadalafil (HY-90009A). Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM.
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- HY-N0830S9
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Palmitic acid- 13C is the 13C-labeled Palmitic acid (HY-N0830). Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
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- HY-W769361
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5-Hydroxymethyl-2-furancarboxylic acid- 13C6 is the 13C-labeled 5-Hydroxymethyl-2-furancarboxylic acid (HY-W005241). 5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural (HMF) in the body and eliminated renally.
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- HY-W008449S1
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1-Methylxanthine- 13C4, 15N3 is the 13C-labeled and 15N-labeled 1-Methylxanthine. 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP) . 1-Methylxanthine enhances the radiosensitivity of tumor cells .
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- HY-B0430S
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Pantothenic acid- 13C3, 15N (hemicalcium) is the 13C-labeled and 15N-labeled D-Pantothenic acid. D-Pantothenic acid is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism .
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- HY-W768262
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D-(+)-Glucono-1,5-lactone- 13C6 (Gluconic acid lactone- 13C6) is the 13C-labeled D-(+)-Glucono-1,5-lactone (HY-I0301). D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.
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- HY-113407CS
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D-Fructose-6-phosphate disodium monohydrate- 13C6 is the 13C-labeled D-Fructose-6-phosphate disodium monohydrate (HY-113407C). D-Fructose-6-phosphate disodium monohydrate is an intermediate of Glycolysis. D-Fructose-6-phosphate disodium monohydrate is the precursor for the synthesis of amino sugars, such as galactosamine and glucosamine .
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- HY-13756S
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Tacrolimus- 13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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- HY-W778511
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Levulinic acid- 13C3 (4-Oxovaleric acid- 13C) is the 13C-labeled Levulinic acid (HY-Y0839). Levulinic acid is a precursor for the synthesis of biofuels, such as ethyl levulinate. Levulinic acid is also a 5-keto-pentanoic acid. Levulinic acid can be utilized by the cells as a cosubstrate for biopolymer synthesis. Levulinic acid can be used in antibacterial research .
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- HY-W766574
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L-Glutamine-5- 13C Hydrochloride is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells .
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- HY-138615S2
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Deoxythymidine-5'-triphosphate- 13C10 (dTTP- 13C10) dilithium is 13C-labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
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- HY-W778286
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Enterolactone- 13C3 is the 13C-labeled Enterolactone (HY-108692). Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .
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- HY-W654247
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Lamivudine- 13C,d2 is the deuterium labeled and 13C-labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .
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- HY-W769288
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Pemetrexed disodium- 13C5 (LY231514 disodium- 13C5) is the 13C-labeled Pemetrexed disodium (HY-10820A). Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively .
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- HY-N1150S11
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Thymidine- 13C10 (DThyd- 13C10; NSC 21548- 13C10) is 13C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
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- HY-W777620
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1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone- 13C,d3 (rac-Cotinine- 13C,d3) is the deuterium and 13C-labeled 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (HY-W588192).
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- HY-136648S5
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2'-Deoxyadenosine-5'-triphosphate- 13C10 (dATP- 13C10) dilithium is 13C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
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- HY-N0830S
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Palmitic acid-1,2,3,4- 13C4 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
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- HY-W777749
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Methoxsalen- 13C,d3 (8-Methoxypsoralen- 13C,d3) is the deuterium and 13C-labeled Methoxsalen (HY-30151). Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.
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- HY-W768772
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Fluroxypyr- 13C2,d2 is the deuterium labeled and 13C-labeled Fluroxypyr (HY-B1842). Fluroxypyr is an auxin herbicide to control annual or perennial weeds. Fluroxypyr icauses auxin overdose or excessive endogenous auxin concentrations, thereby resulting in an imbalance of auxin homeostasis and interaction with other hormones in tissues .
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- HY-N8525S
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3'-O-Acetylthymidine- 13C is the 13C-labeled 3'-O-Acetylthymidine (HY-N8525). 3'-O-Acetylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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- HY-W048482S
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rU Phosphoramidite- 13C2,d1 (DMT-2'O-TBDMS-rU phosphoramidite- 13C2,d1) is deuterium and 13C-labeled rU Phosphoramidite (HY-W048482). rU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
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- HY-W748688
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N4-Acetylsulfamethoxazole- 13C6 (Acetylsulfamethoxazole- 13C6) is the 13C-labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of?Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections .
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- HY-B2176S2
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ATP- 13C (Adenosine 5'-triphosphate- 13C) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
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- HY-W777706
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1-(3,4-Dimethylphenyl)ethan-1-ol- 13C,d3 (1-(3,4-Dimethylphenyl)ethanol- 13C,d3) is the deuterium labeled and 13C-labeled 1-(3,4-Dimethylphenyl)ethan-1-ol (HY-W340128).
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- HY-B2176S6
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ATP- 13C10 (Adenosine 5'-triphosphate- 13C10) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
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- HY-18085S2
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Quercetin- 13C3 is the 13C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .
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- HY-15407S3
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Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .
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- HY-128417S2
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D-Glucose-1,6- 13C2 is the 13C-labeled D-Glucose (HY-B0389). D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .
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- HY-W770250
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Clothianidin-d3, 13C1 is the 13C-labeled Clothianidin (HY-133167). Clothianidin is a neonicotinoid insecticide. Clothianidin shows excellent long-term control effect in small doses against various insect pests such as Coleoptera, Thysanoptera, Lepidoptera, Diptera, Homoptera, Heteroptera, Orthoptera and Isoptera families. Clothianidin has various application methods and high safety for crops .
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- HY-14605BS
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Rasagiline- 13C3 (mesylate racemic) is a 13C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor . Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W101495S
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Boc-Leu-OH·H2O- 13C is a 13C-labeled Boc-Leu-OH (HY-W101495). Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .
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- HY-W749519
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(E,E)-Farnesol- 13C3 (trans,trans-Farnesol- 13C3) is the 13C-labeled (E,?E)?-?Farnesol (HY-Y0248). (E, E)-Farnesol (trans,trans-Farnesol;(2E,6E)-Farnesol) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-101400S4
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Deoxycytidine triphosphate- 13C9 (dCTP- 13C9 dilithium; 2′-Deoxycytidine-5′-triphosphate- 13C9) dilithium is 13C-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
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- HY-W751526
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N4-Acetylsulfamethazine- 13C6 (Sulfamethazine-n4-acetyl- 13C6) is the 13C-labeled N4-Acetylsulfamethazine (HY-W290839). N4-Acetylsulfamethazine is a metabolite of Sulfamethazine (HY-B0035). Sulfamethazine is one of the most frequently used sulfonamides in the poultry farming industry .
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- HY-W778288
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(±)-Enterodiol- 13C3 is the 13C-labeled (±)-Enterodiol (HY-108695B). (±)-Enterodiol is the racemate of Enterodiol (HY-108695). Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Enterodiol has anti-cancer activities .
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- HY-W008452S
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H-Tyr(3-I)-OH- 13C6 is the 13C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .
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- HY-107372S2
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Uridine triphosphate- 13C9 (UTP- 13C9 dilithium; Uridine 5'-triphosphate- 13C9) dilithium is 13C-labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
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- HY-66005S3
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Acetaminophen-13C6 (Paracetamol-13C6) is the 13C-labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
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- HY-113008AS
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cis-Urocanic acid- 13C3 is the 13C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor .
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- HY-W754216
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Diacetone-β-D-fructose- 13C6 (2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose- 13C6) is the 13C-labeled Diacetone-β-D-fructose (HY-W011792). Diacetone-β-D-fructose is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-W768188
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(2r,4r)-Pentane-1,2,3,4,5-pentaoll- 13C2 (D-Arabinitol-1,2- 13C2) is the 13C-labeled (2r,4r)-Pentane-1,2,3,4,5-pentaol (HY-W794625).
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- HY-B0495S
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Lamotrigine- 13C3,d3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .
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- HY-101981S4
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Uridine 5'-monophosphate- 13C9 (5'- Uridylic acid- 13C9) dilithium is 13C-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'- Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
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- HY-W778954
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2,2-Dimethyl-1,3-dioxolane-4-methanol- 13C3 ((2,2-Dimethyl-[1,3] dioxane-4-yl)-methanol- 13C3) is the 13C-labeled 2,2-Dimethyl-1,3-dioxolane-4-methanol (HY-Y1372).
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- HY-W768839
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5-(Hydroxymethyl)cytidine- 13C,d2 is the deuterium labeled and 13C-labeled 5-(Hydroxymethyl)cytidine (HY-152854). 5-(Hydroxymethyl)cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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- HY-W747791
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4,6-Dichloro-1,3,5-triazin-2-amine- 13C3 (s-Triazine, 2-amino-4,6-dichloro- 13C3) is the 13C-labeled 4,6-Dichloro-1,3,5-triazin-2-amine (HY-W008081).
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- HY-B2033S
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Pyrimethanil- 13C, 15N2 is the 13C-labeled and 15N-labeled Pyrimethanil. Pyrimethanil is an?anilinopyrimidine?and broad-spectrum?contact fungicide for the control of Botrytis spp. on a wide variety of crops . Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in?Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection .
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- HY-W748430
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Furagin- 13C3 (Furazidine- 13C3) is the 13C-labeled Furagin (HY-77036). Furagin (Furazidine), an analogue of Nitrofurantoin (HY-A0090), is an antibiotic with antibacterial activity against ESKAPE pathogens with MIC values of 0-32 μg/mL. Furagin inhibits human Carbonic anhydrases . Furagin is promising for research of cancer and urinary tract infections (UTIs) .
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- HY-W766388
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2-Amino-2-deoxyglucose hydrochloride- 13C6 (D-Glucosamine Hydrochloride- 13C6) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
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- HY-W777762
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Dodecanedioic Acid- 13C12 is the 13C-labeled Dodecanedioic acid (HY-W012241). Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus .
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- HY-W751834
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6-Amino-5-nitropyrimidine-2,4(1H,3H)-dione- 13C3 (NSC 99321- 13C3) is the 13C-labeled 6-Amino-5-nitropyrimidine-2,4(1H,3H)-dione (HY-W016913).
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- HY-A0181S3
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Adenosine monophosphate- 13C10 (AMP- 13C10) dilithium is 13C-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction .
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- HY-W654255
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Mandelic Acid- 13C8 ((±)-Mandelic acid- 13C8) is the 13C-labeled Mandelic acid (HY-W015591). Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation .
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- HY-W016009S3
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2'-Deoxyadenosine-5'-monophosphate- 13C10 dilithium is 13C-labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
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- HY-W777526
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Nitisinone- 13C6 is a 13C-labeled Nitisinone (HY-B0607). Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .
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- HY-W755778
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3-Iodothyronamine hydrochloride- 13C6 is the 13C-labeled 3-Iodothyronamine hydrochloride (HY-135065). 3-Iodothyronamine hydrochloride is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure .
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- HY-W778179
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Benoxaprofen- 13C,d3 (LRCL 3794- 13C,d3) is the deuterium and 13C-labeled Benoxaprofen (HY-13568). Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation .
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- HY-W779191
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MeIQx- 13C (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline-2- 13C) is the 13C-labeled MeIQx (HY-W355129). MeIQx, a dietary aromatic amine, is mutagenic compound could be isolated from present in fried beef and beef extracts. MeIQx binds covalently to hemoglobin. MeIQx induces liver tumors .
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- HY-B0636S1
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Triamcinolone acetonide- 13C3 is the 13C-labeled Triamcinolone acetonide (HY-B0636). Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis .
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- HY-W767186
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D-Mannoheptulose- 13C7 is the 13C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .
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- HY-W281364S
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2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine- 13C is the 13C-labeled 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine (HY-W281364). 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine is a mutagenic compound .
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- HY-W768482
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2-Amino-6-hydroxypyrimidin-4(1H)-one- 13C2 (2-Amino-6-hydroxy-1H-pyrimidin-4-one- 13C2) is the 13C-labeled 2-Amino-6-hydroxypyrimidin-4(1H)-one (HY-Y0559).
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- HY-W009162S1
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Cytidine 5′-monophosphate- 13C9 (5'-Cytidylic acid- 13C9 dilithium; 5'-CMP- 13C9) dilithium is 13C-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
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- HY-W010918S3
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Adenosine 5'-diphosphate- 13C5 (Adenosine diphosphate- 13C5) is the 13C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
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- HY-W778240
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2-Naphthoic acid- 13C6 (Naphthalene-2-carboxylic acid- 13C6) is the 13C-labeled 2-Naphthoic acid (HY-W007437). 2-Naphthoic acid is an organic compound commonly used as a raw material for dyes and the production of other chemicals. It can form dyes with other organic substances and is widely used in textile, printing and manufacturing fields. In addition, the compound is also used as a photosensitive material and a lubricant.
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- HY-N5134S1
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5'-Guanylic acid- 13C10 (5'-GMP- 13C10 dilithium; 5'-guanosine monophosphate- 13C10) dilithium is 13C-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
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- HY-W748418
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1-Thio-β-D-glucose Sodium Salt Dihydrate- 13C6 is the 13C-labeled 1-Thio-β-D-glucose sodium (HY-115419). 1-Thio-β-D-glucose sodium is the sodium salt form of 1-Thio-β-D-glucose. 1-Thio-β-D-glucose forms hydrophilic self-assembled monolayer with metal, stablizes the lipid bilayer and protects the proteins from denaturation .
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- HY-W751156
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O-Phospho-L-serine- 13C3 (L-Serine O-phosphate- 13C3) is the 13C-labeled O-Phospho-L-serine (HY-15129). O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .
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- HY-W748519
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Sarcosine- 13C3 (N-Methylglycine- 13C3; Sarcosin- 13C3) is the 13C-labeled Sarcosine (HY-101037). Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .
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- HY-N0322S4
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Cholesterol- 13C3 is the 13C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .
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- HY-116084S1
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Trimethylamine-N-oxide- 13C3 is the 13C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .
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- HY-N6786S
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Ochratoxin B- 13C20 is 13C-labeled Ochratoxin B (HY-N6786). Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .
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- HY-W768178
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2-Amino-2-deoxyglucose hydrochloride- 13C2 (D-Glucosamine Hydrochloride-1,2- 13C2) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
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- HY-W777120
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Cisapride- 13C,d3 (R 51619- 13C,d3) is the deuteriumand 13C-labeled Cisapride (HY-14149). Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. Cisapride is a hERG blocker with an IC50 value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity .
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- HY-W747879
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Diclofenac Amide- 13C6 is the 13C-labeled Diclofenac amide (HY-134521). Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) .
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- HY-18572S
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2,4-D- 13C6 is the 13C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development .
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- HY-W759219
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Adrenosterone- 13C3 ((+)-Adrenosterone- 13C3) is the 13C-labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor.
Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .
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- HY-B0152S3
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Adenine- 13C5 (6-Aminopurine- 13C5; Vitamin B4- 13C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA.
Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
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- HY-129503S
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2-Heptyl-4-quinolone- 13C6 is the 13C-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .
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- HY-W777281
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Fluocinolone acetonide- 13C3 is the 13C-labeled Fluocinolone (Acetonide) (HY-B0415). Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015) .
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- HY-W749825
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Pentetic acid- 13C5 (Diethylenetriaminepentaacetic acid- 13C5) is the 13C-labeled Pentetic acid (HY-B1335). Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide .
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- HY-136380S
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Clodinafop-propargyl- 13C6 is the 13C-labeled Clodinafop-propargyl. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl-13C6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-N0322S3
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Cholesterol- 13C5 is the 13C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .
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- HY-W765245
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Rapamycin- 13C,d3-1 (Sirolimus- 13C,d3-1) is the deuterium labeled and 13C-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .
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- HY-B1804S
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Tricaprilin- 13C3 (Trioctanoin- 13C3) is a 13C-labeled Tricaprilin (HY-B1804) . Tricaprilin is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .
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- HY-N1428S1
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Citric acid- 13C6 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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- HY-W753181
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(S)-2-Hydroxy-3-phenylpropanoic acid- 13C9 (L-(-)-3-Phenyllactic Acid- 13C9) is the 13C-labeled (S)-2-Hydroxy-3-phenylpropanoic acid (HY-30220). (S)-2-Hydroxy-3-phenylpropanoic acid is the L-configuration of 2-Hydroxy-3-phenylpropanoic acid, and its level is closely related to some diseases, such as phenylketonuria .
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- HY-N0086S2
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N6-Methyladenosine- 13C4 (6-Methyladenosine- 13C4; N-Methyladenosine- 13C4) is 13C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.
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- HY-W750959
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L-Methionine sulfoxide- 13C (H-Met(O)-OH- 13C) is the 13C-labeled L-Methionine sulfoxide (HY-W010104). L-Methionine sulfoxide is an orally active oxidation product of Methionine (HY-N0326). L-Methionine sulfoxide can be partially converted into Methionine in the body and participate in the synthesis of glutathione in the liver. L-Methionine sulfoxide provides the body with sulfur activity and can participate in the synthesis of proteins and sulfur-containing compounds .
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- HY-N0086S3
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N6-Methyladenosine- 13C3 (6-Methyladenosine- 13C3) is 13C-labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities .
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- HY-N1428S3
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Citric acid- 13C3 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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- HY-W778335
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Dimethyl Phthalate- 13C2 (DMP- 13C2) is the 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
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- HY-13653S
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(+/-)-Epigallocatechin Gallate- 13C3 is the 13C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects . (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.
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- HY-15037S
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Diclofenac- 13C6 (sodium heminonahydrate) is the 13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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- HY-W747751
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Sorbic acid- 13C2 is the 13C-labeled Sorbic acid (HY-N0626). Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways .
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- HY-W754236
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(R)-Carnitine Hydrochloride- 13C3 is the 13C-labeled L-Carnitine hydrochloride (HY-B2246). L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .
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- HY-A0067S1
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Oxybenzone- 13C6 (Benzophenone 3- 13C6) is the 13C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
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- HY-128393S1
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Trilinolein- 13C54 is the 13C-labeled Trilinolein (HY-128393). Trilinolein is an orally active triglyceride that inhibits the PI3K/Akt, Ras/MEK/ERK signaling pathways, and MMP-2. Trilinolein can reduce oxidative stress, induce apoptosis, and inhibit cell migration. Trilinolein can be used in the research fields of cardiovascular disease, cerebrovascular disease (such as cerebral ischemia), and non-small cell lung cancer .
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- HY-W777169
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Bexarotene- 13C4 (LGD1069- 13C4) is the 13C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
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- HY-B0166S1
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L-Ascorbic acid- 13C is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
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- HY-B0228S13
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Adenosine- 13C10 (Adenine riboside- 13C10; D-Adenosine- 13C10) is 13C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
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- HY-B0113S3
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Omeprazole- 13C,d3 is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
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- HY-B0166S
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L-Ascorbic acid- 13C6 is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
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- HY-W778242
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3,4-Dihydronaphthalen-1-one- 13C6 (3,4-Dihydro-1(2H)-naphthalenon- 13C6) is the 13C-labeled 3,4-Dihydronaphthalen-1(2H)-one (HY-76194). 3,4-Dihydronaphthalen-1(2H)-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W766136
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Aprepitant Impurity 9- 13C2,d2 (2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenyl-4-[(2-N-methoxycarbonyl)acetamidrazono]morpholine- 13C2,d2) is the deuterium labeled and 13C-labeled Aprepitant Impurity 9 (HY-Z11099).
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- HY-W009300S1
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4-Hydroxyestrone- 13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .
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- HY-N7106S3
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Dimethyl phthalate- 13C6 (DMP- 13C6) is the 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
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- HY-W127841
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Citric acid-2,4- 13C2 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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- HY-W008048S
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2',3'-O-Isopropylideneadenosine- 13C5 is the 13C-labeled 2',3'-O-Isopropylideneadenosine (HY-W008048). 2',3'-O-Isopropylideneadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .
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- HY-W751180
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3-Hydroxy Midostaurin- 13C6 (CGP52421- 13C6) is the 13C-labeled 3-Hydroxy Midostaurin (HY-108263). 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .
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- HY-W654296
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Octocrylene- 13C3 is the 13C-labeled Octocrylene (HY-A0087). Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes .
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- HY-W777084
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(E)-3,4-Dimethoxycinnamic acid- 13C3 ((E)-O-Methylferulic acid- 13C3) is the 13C-labeled (E)-3,4-Dimethoxycinnamic acid (HY-N1778A). (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .
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- HY-W747676
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Glyphosate- 13C is the 13C-labeled Glyphosate (HY-B0863). Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .
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- HY-16938S
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5'-Methylthioadenosine- 13C6 is the 13C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .
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- HY-A0181S
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1 Publications Verification
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Adenosine monophosphate- 13C10, 15N5(AMP- 13C10, 15N5) is the 13C-labeled and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction .
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- HY-151997S
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1,2-Dioleoyl-3-lauroyl-rac-glycerol- 13C3 is the 13C-labeled 1,2-Dioleoyl-3-lauroyl-rac-glycerol (HY-165089), 1,2-Dioleoyl-3-lauroyl-rac-glycerol (1,2-Olein-3-laurin) is a triglyceride identified by specific analytical methods in human milk, infant formula, other mammalian milk, and vegetable oils, with specific structural and distribution characteristics.
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- HY-138616S3
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dGTP- 13C10 (2'-Deoxyguanosine-5'-triphosphate- 13C10) dilithium is 13C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
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- HY-W738273
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Veratric acid- 13C (3,4-Dimethoxybenzoic acid- 13C) is the 13C-labeled Veratric acid (HY-N2007). Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities . Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling . Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation .
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- HY-107867S2
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Clopidogrel- 13C,d3 sulfate is the deuterium and 13C-labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .
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- HY-W768336
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Gluconate sodium- 13C6 (D-Gluconic acid sodium salt- 13C6) is the 13C-labeled Gluconate sodium (HY-B1092A). Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury .
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- HY-W011012S
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Adenosine 5'-monophosphate- 13C (disodium) is a 13C-labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .
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- HY-W749394
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4-Methyl-5-thiazoleethanol- 13C3 is the 13C-labeled 4-Methyl-5-thiazoleethanol (HY-W015695). 4-Methyl-5-thiazoleethanol is a natural sulfur-containing flavor compound with the aroma of beef and nuts. In addition, the composite material prepared by modifying graphene oxide with 4-Methyl-5-thiazoleethanol through a one-step esterification reaction can selectively adsorb copper ions (Cu2+) in aqueous solutions .
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- HY-W738270
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Veratraldehyde- 13C (3,4-Dimethoxy[7- 13C]-benzaldehyde) is the 13C-labeled Veratraldehyde (HY-N1096). Veratraldehyde is an orally active aromatic compound and antibacterial agent. Veratraldehyde can be isolated from essential oils of plants such as peppermint and ginger. Veratraldehyde targets the PilY1 protein. Veratraldehyde has antibacterial activity against Pseudomonas aeruginosa. Veratraldehyde has a repellent effect against mosquitoes and ticks. Veratraldehyde can be used as a flavoring agent .
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- HY-W753345
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2,6-Dichlorodiphenylamine- 13C6 (2,6-Dichloro-N-phenylaniline- 13C6) is the 13C-labeled 2,6-Dichlorodiphenylamine (HY-W012126). 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a?COX?inhibitor, with?IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
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- HY-W777959
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Azasetron Hydrochloride- 13C,d3 is the deuterium and 13C-labeled Azasetron (HY-B0019). Azasetron ((Rac)-SENS-401 free base) is an antiemetic drug with 5-HT3 receptor antagonist activity. Azasetron is often used as a preventive measure for postoperative nausea and vomiting or chemotherapy-induced nausea and vomiting. Azasetron does not impair neutrophil chemotaxis or phagocytosis and does not scavenge O(-)(2) or H(2)O(2) generated by cell-free systems .
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- HY-W266188
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Decanoic acid- 13C is the 13C-labeled Decanoic acid (HY-W015309). Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy .
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- HY-114293S4
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Acetyl coenzyme A- 13C2-1 sodium (Acetyl-CoA- 13C2-1 sodium) is the 13C-labeled Acetyl coenzyme A (HY-114293). Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis .
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- HY-12516S2
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Desogestrel- 13C2,d2-1 (Org-2969- 13C2,d2-1) is the deuterium labeled and 13C-labeled Desogestrel (HY-12516). Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
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- HY-N0215S8
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L-Phenylalanine- 13C6 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
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- HY-N0215S10
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L-Phenylalanine- 13C9 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
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- HY-W754064
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Cytidine-5'-triphosphate- 13C5 (Cytidine triphosphate- 13C5) is the 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii .
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- HY-N0215S7
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L-Phenylalanine-3- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
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- HY-N0411S4
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β-Carotene- 13C10 (Provitamin A- 13C10) is the 13C-labeled β-Carotene (HY-N0411). β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .
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- HY-N0215S2
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L-Phenylalanine- 13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
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- HY-W751181
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O-Desmethyl midostaurin- 13C6 (CGP62221- 13C6; O-Desmethyl PKC412- 13C6) is the 13C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor?with?IC50?ranging from 22-500 nM.
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- HY-W767601
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(3S,6S)-3,6-Dimethyl-1,4-dioxane-2,5-dione- 13C2 (L-Lactide- 13C2) is the 13C-labeled L-Lactide (HY-W020691A). (3S,6S)-3,6-Dimethyl-1,4-dioxane-2,5-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-N2362S
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DL-Alanine- 13C-1 is the 13C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver .
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- HY-W768934
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L-Gulono-1,4-lactone- 13C6 (L-Gulonolactone- 13C6) is the 13C-labeled L-Gulono-1,4-lactone (HY-W016628). L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
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- HY-113066S1
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Guanosine 5'-diphosphate- 13C10 (GDP- 13C10) dilithium is 13C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).
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- HY-N2362S1
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DL-Alanine- 13C-3 is the 13C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver .
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- HY-W753201
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5'-Methylthioadenosine- 13C (5'-(Methylthio)-5'-deoxyadenosine- 13C) is the 13C-labeled 5'-Methylthioadenosine (HY-16938). 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .
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- HY-112499S1
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Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .
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- HY-W754400
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Mannosan,95%- 13C6 (1,6-Anhydro-β-D-mannopyranose- 13C6) is the 13C-labeled Mannosan,95% (HY-124095). Mannosan,95% (1,6-Anhydro-β-D-mannopyranose,95%) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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- HY-N7106S2
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Dimethyl phthalate- 13C6,d4 (DMP- 13C6,d4) is the deuterium labeled and 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
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- HY-12033S1
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2-Methoxyestradiol- 13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .
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- HY-W040329S1
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2'-Deoxyadenosine- 13C10 is 13C-labeled 2'-Deoxyadenosine (HY-W040329) . 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .
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- HY-W777365
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Ethylenediaminetetraacetic acid- 13C4 (EDTA- 13C4) is the 13C-labeled Ethylenediaminetetraacetic acid (HY-Y0682). Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .
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- HY-W750674
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Indole-3-carboxaldehyde- 13C8 (3-Formylindole- 13C8) is the 13C-labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde, a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract .
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- HY-B0152S2
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Adenine- 13C5,15C5 (6-Aminopurine- 13C5,15C5; Vitamin B4- 13C5,15C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
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- HY-W777458
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Fluorene- 13C6 is the 13C-labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .
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- HY-B0822S1
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Fipronil- 13C6 is the 13C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.
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- HY-W738271
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Veratryl alcohol- 13C (3,4-Dimethoxybenzyl alcohol- 13C) is the 13C-labeled Veratryl alcohol (HY-107858). Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H2O2 and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy .
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- HY-125818S3
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Cytidine-5'-triphosphate- 13C9 (Cytidine triphosphate- 13C9 dilithium; 5'-CTP- 13C9) dilithium is 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
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- HY-16561S1
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Resveratrol- 13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
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- HY-W751179
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Midostaurin- 13C6 (PKC412- 13C6) is the 13C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .
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- HY-78726S2
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Fosamprenavir- 13C6 is the 13C-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .
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- HY-W777393
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Umbelliferone- 13C6 (7-Hydroxycoumarin- 13C6) is the 13C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in
chronic alcohol-fed rats .
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- HY-W756467
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Antibacterial agent 265- 13C,d3 (1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid- 13C,d3) is the deuterium labeled and 13C-labeled Antibacterial agent 265 (HY-W018629). Antibacterial agent 265 (Compound 2) is an antibacterial agent. Antibacterial agent 265 shows antibacterial activity against Staphylococcus Aureus, Micrococcus Luteus, Bacillus subtilis, gram-negative Escherichia coli, Pseudomonas aeruginosa and Flavobacterium devorans .
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- HY-W777283
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Idebenone- 13C,d3 is the deuterium labeled and 13C-labeled Idebenone (HY-N0303). Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM) . Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells . Idebenone quickly crosses the blood-brain barrier.
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- HY-Y1352S
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Potassium cyanate- 13C is the 13C labeled Potassium cyanate .
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- HY-151097S
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(±)-Benzfendizone- 13C is the 13C labeled (±)-Benzfendizone .
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- HY-Y1220S
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Potassium carbonate- 13C is the 13C labeled Potassium carbonate .
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- HY-Y1213S
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1 Publications Verification
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Carbon- 13C is the 13C labeled Carbon .
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- HY-B1449S1
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Uridine- 13C is the 13C labeled Uridine .
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- HY-154773S
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Artesunate- 13C4 is 13C labeled Artesunate.
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- HY-B0174AS
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Olsalazine- 13C6 is the 13C labeled Olsalazine.
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- HY-W768581
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Acetoin- 13C4 is 13C labeled Acetoin.
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- HY-W088065S
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Formate- 13C (sodium) is the 13C labeled Sodium formate .
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- HY-B1773AS
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Propanoic- 13C (sodium) is the 13C labeled Sodium Propionate .
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- HY-Y0847S
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Potassium thiocyanate- 13C is the 13C labeled Potassium thiocyanate .
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- HY-W768213
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2'-Deoxyguanosine monohydrate- 13C5 is the 13C-labeled 2'-Deoxyguanosine monohydrate (HY-D0185). 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1O2, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer .
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- HY-W747060
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Benzyl 4-hydroxybenzoate- 13C6 (Benzyl Paraben- 13C6) is the 13C-labeled Benzyl 4-hydroxybenzoate (HY-W013482). Benzyl 4-hydroxybenzoate is a prominent material. Benzyl 4-hydroxybenzoate can be used as an excipient, such as bacteriostatic agent, preservative. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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- HY-W251598S
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Bicarbonate- 13C sodium is the 13C-labeled Sodium bicarbonate (HY-Y0756). Sodium bicarbonate is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort .
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- HY-N0537S2
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Xylose-1- 13C is the 13C labeled Xylose.
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- HY-W769017
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Thiothiamine- 13C3 is 13C labeled Thiothiamine .
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- HY-N0537S5
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Xylose-3- 13C is the 13C labeled Xylose.
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- HY-121267S
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Dicamba- 13C6 is the 13C labeled Dicamba .
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- HY-W654118
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Cloxacillin- 13C4 (sodium) is 13C labeled Cloxacillin (sodium) .
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- HY-122062S
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Fenoxycarb- 13C6 is the 13C labeled Fenoxycarb .
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- HY-N0537S6
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Xylose-4- 13C is the 13C labeled Xylose.
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- HY-W035903S
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Ethanolamine- 13C2 hydrochloride is the 13C labeled Ethanolamine hydrochloride .
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- HY-N0537S4
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Xylose-5- 13C is the 13C labeled Xylose.
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- HY-152072S
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Deoxynivalenol- 13C15 is the 13C labeled Deoxynivalenol .
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- HY-W777964
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Phloroglucinol- 13C6 is 13C labeled Phloroglucinol .
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- HY-150679S
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Remdesivir- 13C6 is the 13C labeled Remdesivir .
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- HY-W770434
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Octrizole- 13C6 is 13C labeled Octrizole .
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- HY-W010407S
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Cyanuric acid- 13C3 is the 13C labeled Cyanuric acid .
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- HY-141939S
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Triiodothyronine- 13C6 (hydrochloride) is the 13C labeled Triiodothyronine .
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- HY-I0400S
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N-Acetylneuraminic acid- 13C is the 13C labeled N-Acetylneuraminic acid.
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- HY-W778142
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Dimethyl Phosphate- 13C2 (sodium) is 13C labeled Dimethyl Phosphate (sodium) .
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- HY-W344468S
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Adipate- 13C6 (sodium) is the 13C labeled Sodium adipate .
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- HY-N2024AS2
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Maltose monohydrate- 13C is the 13C labeled isotope of Maltose monohydrate .
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- HY-W747621
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Ethyl formate- 13C is 13C labeled Ethyl formate.
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- HY-W780180
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Tetrabromobisphenol A- 13C12 is 13C labeled Tetrabromobisphenol A .
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- HY-B1773AS3
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Propanoic- 13C3 (sodium) is the 13C labeled Sodium Propionate .
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- HY-W585933S
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Fructose-alanine- 13C6 is 13C labeled Fructose-alanine.
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- HY-106950CS
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Fosfructose-1- 13C (sodium) is the 13C labeled Fosfructose .
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- HY-B0451AS5
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Dopamine- 13C (hydrochloride) is the 13C labeled Dopamine hydrochloride (ASL279) .
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- HY-W585934S
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Fructose-phenylalanine- 13C6 is 13C labeled Fructose-phenylalanine.
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- HY-B0400AS
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L-Sorbitol- 13C is the 13C labeled L-Sorbitol .
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- HY-W012584S
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L-Arabinopyranose- 13C is the 13C labeled L-Arabinopyranose .
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- HY-106950CS1
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Fosfructose-2- 13C (sodium) is the 13C labeled Fosfructose .
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- HY-106950CS3
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Fosfructose-6- 13C (sodium) is the 13C labeled Fosfructose .
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- HY-Y0827S
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Carbonate- 13C (barium) is the 13C labeled Barium carbonate .
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- HY-146994S
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L-Idose- 13C is the 13C labeled L-Idose .
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- HY-N2024AS1
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Maltose monohydrate- 13C12 is the 13C labeled isotope of Maltose monohydrate .
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- HY-150194S
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Fructose-glutamic acid- 13C6 is 13C labeled Fructose-glutamic acid.
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- HY-146995S
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Glycolaldehyde-1- 13C is the 13C labeled Glycolaldehyde .
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- HY-N0059AS
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L-(+)-Lyxose- 13C is the 13C labeled L-Lyxose .
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- HY-W015824S
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DL-Aspartic acid- 13C is the 13C labeled DL-Aspartic acid .
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- HY-W028026S
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Methacetin-methoxy- 13C is the 13C labeled Methacetin-methoxy .
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- HY-146995S1
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Glycolaldehyde-2- 13C is the 13C labeled Glycolaldehyde .
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- HY-N0667S3
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L-Asparagine- 13C4 monohydrate is the 13C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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- HY-W750212
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Acid Orange 7- 13C6 (Orange II- 13C6) is the 13C-labeled Acid orange 7 (HY-N1442). Acid Orange 7 (Orange II; D&C Orange NO. 4) is an azo dye widely used in the textile, food and cosmetic industries. Acid Orange 7 is mainly used as a colorant by combining with fibers and other substances through azo bonds. Acid Orange 7 has a maximum absorption wavelength at 484-485 nm, and the concentration is measured using a UV-visible spectrophotometer. Acid Orange 7 is difficult to degrade and has a certain degree of toxicity. It is often used to study various sewage treatment technologies and photocatalytic degradation reactions, and to evaluate the removal effects of different treatment methods on organic pollutants .
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- HY-N0667S4
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L-Asparagine-4- 13C monohydrate is the 13C-labeled L-Asparagine monohydrate (HY-W017443).L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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- HY-125818S2
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Cytidine-5'-triphosphate- 13C,d1 (Cytidine triphosphate- 13C,d1 dilithium; 5'-CTP- 13C,d1) dilithium is deuterium and 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
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- HY-W778408
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Tamoxifen- 13C6 (ICI 47699- 13C6) is the 13C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER transgenic mouse .
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- HY-W777675
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2,5-Deoxyfructosazine- 13C4 (NSC 270912- 13C4) is the 13C-labeled 2,5-Deoxyfructosazine (HY-135078). 2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50=~1.25 mM).
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- HY-W001132S1
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Indole- 13C is the 13C labeled Indole . Indole is an endogenous metabolite.
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- HY-150915S
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Uracil 4,5- 13C2 is the 13C labeled Uracil .
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- HY-Y0262BS
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Oxalic Acid- 13C2 (disodium) is the 13C labeled Oxalic Acid disodium .
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- HY-Y0338S1
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Ethylene glycol- 13C2 is the 13C labeled Ethylene glycol .
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- HY-N0538S2
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Xylitol-5- 13C is the 13C labeled Xylit .
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- HY-W748319
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K 101- 13C12 is 13C labeled K 101 .
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- HY-113296S
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Indoxyl Sulfate Potassium Salt- 13C6 is the 13C labeled Indoxyl Sulfate Potassium Salt .
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- HY-130585S
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Estradiol undecylate- 13C3 is the 13C labeled Estradiol undecylate .
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- HY-W015824S3
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DL-Aspartic acid- 13C1 is the 13C labeled DL-Aspartic acid .
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- HY-Y0546S2
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Benzophenone- 13C is the 13C labeled Benzophenone . Benzophenone is an endogenous metabolite.
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- HY-B0892S3
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Benzyl alcohol- 13C6 is the 13C labeled Benzyl alcohol .
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- HY-B1449S4
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Uridine- 13C-3 is the 13C labeled Uridine .
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- HY-B1449S7
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Uridine 13C-4 is the 13C labeled Uridine .
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- HY-W774917S
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trans Chlordane- 13C10 is 13C labeled trans-Chlordane .
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- HY-B1449S3
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Uridine- 13C-2 is the 13C labeled Uridine .
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- HY-N0378S3
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D-Mannitol-2- 13C is the 13C labeled D-Mannitol.
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- HY-N0538S
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Xylitol-1- 13C is the 13C labeled Xylit .
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-
- HY-W753532
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Bisphenol B- 13C12 is 13C labeled Bisphenol B .
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- HY-N0538S1
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Xylitol-2- 13C is the 13C labeled Xylit .
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-
- HY-W016145S
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L-Glutamic acid- 13C5 (hydrate salt) is the 13C labeled L-Glutamic acid hydrate salt .
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- HY-Y0589S
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m-Cyanobenzoic acid- 13C6 is the 13C labeled m-Cyanobenzoic acid .
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- HY-166934S
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Endosulfan- 13C9 (sulfate) is 13C labeled Endosulfan (sulfate) .
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- HY-B0451AS1
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Dopamine- 13C6 (hydrochloride) is the 13C labeled Dopamine hydrochloride (ASL279) .
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- HY-166919S
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cis-Chlordane- 13C8 is 13C labeled cis-Chlordane .
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- HY-B1449S2
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Uridine- 13C-1 is the 13C labeled Uridine .
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- HY-77956S
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Thyminose- 13C is the 13C labeled Thyminose. Thyminose is an endogenous metabolite .
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- HY-I0400S2
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N-Acetylneuraminic acid- 13C-2 is the 13C labeled N-Acetylneuraminic acid.
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- HY-W338294S2
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2'-Deoxyguanosine- 13C (monohydrate) Monohydrate is the 13C labeled 2'-Deoxyguanosine .
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- HY-W338294S
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2'-Deoxycytidine- 13C (monohydrate) is the 13C labeled 2'-Deoxycytidine .
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- HY-B1659AS
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D-Glycerol-3- 13C is the 13C labeled D-Glycerol .
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- HY-B1092AS
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Gluconate-1- 13C (sodium) is the 13C labeled Gluconate sodi .
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- HY-146996S
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β-lactosyl- 13C is the 13C labeled β-lactosy .
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- HY-I0400S1
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N-Acetylneuraminic acid- 13C-1 is the 13C labeled N-Acetylneuraminic acid.
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- HY-141925S
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3-Octanone- 13C is the 13C labeled 3-Octanone .
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- HY-116956S3
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D-Erythrose-4- 13C is the 13C labeled D-Erythrose .
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- HY-W067028S
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Semicarbazide- 13C, 15N2 hydrochloride is 15N and 13C labeled Semicarbazide.
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- HY-W099580S
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Hexadecane-1,2- 13C2 is the 13C labeled Hexadecane .
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- HY-W005355S2
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Sodium 2-oxobutanoate- 13C (hydrate) is the 13C labeled Sodium 2-oxobutanoate .
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- HY-116956S
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D-Erythrose-1- 13C is the 13C labeled D-Erythrose .
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- HY-116956S1
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D-Erythrose-2- 13C is the 13C labeled D-Erythrose .
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- HY-I0400S3
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N-Acetylneuraminic acid- 13C-3 is the 13C labeled N-Acetylneuraminic acid.
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- HY-W145612S
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D-Talitol-1- 13C is the 13C labeled D-Talitol .
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- HY-N7092AS
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L-Fructose-1- 13C is the 13C labeled L-Fructose .
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- HY-W585866S
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Alternariol, methyl ether- 13C15 is a 13C labeled Alternariol, methyl ether.
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- HY-W343292S
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2-Methylbutyl acetate- 13C2 is 13C labeled 2-Methylbutyl acetate.
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- HY-116956S2
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D-Erythrose-3- 13C is the 13C labeled D-Erythrose .
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- HY-W142434S
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D-Galactose- 13C-1 is the 13C labeled D-galactopyranose .
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- HY-W011240S
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Hydroflumethiazide- 13C,d2 is the deuterium and 13C labeled Hydroflumethiazide .
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- HY-Y1027S
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2-Chlorobenzoic Acid- 13C7 is the 13C labeled 2-Chlorobenzoic Acid .
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- HY-W010696AS
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Reverse T3- 13C6 (hydrochloride) is the 13C labeled Reverse T3 .
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- HY-B1941S1
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4-tert-Octylphenol- 13C6 is the 13C labeled isotope of Octylphenol .
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- HY-W016508S1
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L-(-)-Mannose- 13C-1 is the 13C labeled L-(-)-Mannose .
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- HY-W007318S
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2-Iodoaniline- 13C6 is the 13C labeled 2-Iodoaniline .
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- HY-128748S
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DL-Glyceraldehyde-1- 13C is the 13C labeled DL-Glyceraldehyde[1].
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- HY-N8847S
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α-Ionone- 13C3 is the 13C labeled α-Ionone .
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- HY-Y0383S2
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Dimethyl terephthalate- 13C2-1 is 13C labeled Dimethyl terephthalate.
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- HY-150703S
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4-Methoxyestradiol- 13C6 is the 13C labeled 4-Methoxyestradiol .
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- HY-W017387S1
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Sodium α-ketoisocaproic acid- 13C2 is the 13C labeled Sodium α-ketoisocaproic acid .
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- HY-139427S
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3-Methylglutaconic acid- 13C3 is the 13C labeled 3-Methylglutaconic acid .
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- HY-150707S
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DL-A-phosphatidylcholine, dipalmitoyl- 13C40 is the 13C labeled DL-A-phosphatidylcholine, dipalmitoyl .
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- HY-W145652S1
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D-Altrose-2- 13C is the 13C labeled D(+)-Altrose[1].
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- HY-Y0721S
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3-Bromofluorobenzene- 13C6 is the 13C labeled 3-Bromofluorobenzene .
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- HY-W104010S
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2-Chloroaniline hydrochloride- 13C6 is the 13C labeled 2-Chloroaniline hydrochloride .
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- HY-W001138S
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4-Bromobenzaldehyde- 13C6 is the 13C labeled 4-Bromobenzaldehyde .
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-
- HY-W779015
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5-Methyluridine- 13C5 is 13C labeled 5-Methyluridine .
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- HY-34428S
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4-Fluorobenzonitrile- 13C6 is the 13C labeled 4-Fluorobenzonitrile .
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- HY-N0378S1
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D-Mannitol- 13C is the 13C labeled D-Mannitol .
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- HY-133689AS
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3-Nitrophenylhydrazine- 13C6 (hydrochloride) is the 13C labeled 3-Nitrophenylhydrazine hydrochloride .
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- HY-158034S
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U-13C Hemicellulose from potato is the 13C labeled Hemicellulose .
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- HY-W777533
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N-Acetyl sulfadiazine- 13C6 is 13C labeled N-Acetyl sulfadiazine .
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- HY-143848S
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Tadalafil- 13C,d3 is the deuterium and 13C labeled Tadalafil .
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- HY-N0059AS1
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L-(+)-Lyxose- 13C-1 is the 13C labeled L-Lyxose .
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- HY-12651AS
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Primaquine- 13C,d3 is the deuterium and 13C labeled Primaquine .
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- HY-W013677S
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4-Fluorobenzoic acid- 13C6 is the 13C labeled 4-Fluorobenzoic acid .
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-
- HY-10250S
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Triciribine phosphate-- 13C,d3 is the deuterium and 13C labeled Triciribine phosphate .
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- HY-141909S
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4-Fluoroiodobenzene- 13C6 is the 13C labeled 4-Fluoroiodobenzene .
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- HY-13577S
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Oclacitinib- 13C-d3 is the deuterium and 13C labeled Oclacitinib .
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-
- HY-143804S
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Cefditoren- 13C,d3 is the deuterium and 13C labeled Cefditoren .
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-
- HY-W005355S9
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Sodium 2-oxobutanoate- 13C4 is the 13C labeled Sodium 2-oxobutanoate .
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-
- HY-128748S2
-
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DL-Glyceraldehyde- 13C,d is the deuterium and 13C labeled DL-Glyceraldehyde .
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-
- HY-W017387S2
-
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Sodium α-ketoisocaproic acid- 13C6 is the 13C labeled Sodium α-ketoisocaproic acid .
|
-
- HY-W770410
-
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9-PAHSA- 13C4 is 13C labeled 9-PAHSA .
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-
- HY-17508S
-
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Clarithromycin- 13C,d3 is the deuterium and 13C labeled Clarithromycin .
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-
- HY-W145492S3
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D-(+)-Talose- 13C-1 is the 13C labeled D-(+)-Talose .
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-
- HY-141928S
-
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4-Bromoanisole- 13C6 is the 13C labeled 4-Bromoanisole .
|
-
- HY-146994S2
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L-Idose- 13C-2 is the 13C labeled L-Idose .
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-
- HY-Y0931S
-
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3-Iodobenzoic Acid- 13C6 is the 13C labeled 3-Iodobenzoic Acid .
|
-
- HY-W145652S
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D-Altrose-1- 13C is the 13C labeled D(+)-Altrose[1].
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-
- HY-143786S
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Tazobactum ester- 13C,d3 is the deuterium and 13C labeled Tazobactum ester .
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-
- HY-W015824S2
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DL-Aspartic acid-3- 13C is the 13C labeled DL-Aspartic acid .
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-
- HY-B0400AS1
-
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L-Sorbitol- 13C-1 is the 13C labeled L-Sorbitol .
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-
- HY-Y1027S1
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2-Chlorobenzoic acid- 13C6 is the 13C labeled 2-Chlorobenzoic acid .
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-
- HY-146994S1
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L-Idose- 13C-1 is the 13C labeled L-Idose .
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-
- HY-113062S
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20a-Dihydroprogesterone- 13C5 is the 13C labeled 20a-Dihydroprogesterone .
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-
- HY-N2353S
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Arabinose-1- 13C is the 13C labeled Arabinose. Arabinose is an endogenous metabolite .
|
-
- HY-W772341
-
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Acetic acid-1- 13C is 13C labeled Acetic acid-1.
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-
- HY-I0459S
-
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Apixaban acid- 13C,d3 is the deuterium and 13C labeled Apixaban acid .
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-
- HY-W013396S
-
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4-Iodobenzoic Acid- 13C6 is the 13C labeled 4-Iodobenzoic Acid .
|
-
- HY-I0210S
-
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4-Iodoaniline- 13C6 is the 13C labeled 4-Iodoaniline .
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-
- HY-131501S1
-
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Menaquinone-9- 13C6 is the 13C labeled Menaquinone-9 .
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-
- HY-W140740S
-
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Hexabromobenzene- 13C6 (Perbromobenzene- 13C6) is 13C labeled Hexabromobenzene .
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-
- HY-W012584S1
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L-Arabinopyranose- 13C-1 is the 13C labeled L-Arabinopyranose .
|
-
- HY-N6614S1
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L-Galactose- 13C-1 is the 13C labeled L-Galactose .
|
-
- HY-N6714S2
-
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Alternariol- 13C14 is a 13C labeled Alternariol (HY-N6714) .
|
-
- HY-128748S1
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DL-Glyceraldehyde-2- 13C is the 13C labeled DL-Glyceraldehyde[1].
|
-
- HY-17506S1
-
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Azithromycin- 13C,d3 is the deuterium and 13C labeled Azithromycin .
|
-
- HY-W767865
-
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Cyclic GMP sodium- 13C5 is the 13C-labeled Cyclic GMP sodium (HY-113469A). Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current ICa, and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases .
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-
- HY-W753593
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N4-Acetylcytidine- 13C5 is the 13C-labeled N4-Acetylcytidine (HY-W019670). N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain NLRP3 inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity .
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-
- HY-W017443S
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L-Asparagine- 13C4, 15N2 monohydrateis the 13C-labeled and 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
|
-
- HY-W778990
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2-Deoxyuridine-1,2,3,4,5- 13C5 is the 13C-labeled 2'-Deoxyuridine (HY-D0186). 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .
|
-
- HY-W017540S
-
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Cyclocreatine- 13C3 is the 13C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .
|
-
- HY-B1422S
-
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|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-N0667S
-
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|
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L-Asparagine- 13C4, 15N2,d8 is the 13C-labeled and 15N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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-
- HY-W769991
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Lactate sodium (60% in water)- 13C2 (Lactic acid sodium- 13C2) is the 13C-labeled Lactate sodium (60% in water) (HY-B2227B). Lactate (60% in water) (Lactic acid) sodium is the product of glycogenolysis and glycolysis . Lactate sodium (60% in water) is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium (60% in water) can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium (60% in water) is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium (60% in water) is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection . Lactate sodium (60% in water) also has antimicrobial activity, which can be used as a food preservative .
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-
- HY-77956S1
-
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Thyminose- 13C-1 is the 13C labeled Thyminose. Thyminose is an endogenous metabolite .
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-
- HY-W009204S3
-
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|
Fmoc-Ala-OH-3- 13C is the 13C labeled Fmoc-Ala-OH .
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-
- HY-77956S2
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|
Thyminose- 13C-2 is the 13C labeled Thyminose. Thyminose is an endogenous metabolite .
|
-
- HY-W768398
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Ethephon- 13C2 is 13C labeled Ethephon. Ethephon is a plant growth regulator .
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-
- HY-W156840S
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OTNE- 13C3 is 13C labeled 2-methoxy-4-propylphenol.
|
-
- HY-128741S
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D-Allose- 13C is the 13C labeled D-Allose. D-Allose is an endogenous metabolite .
|
-
- HY-W021400S
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Sodium 2-Methylpropionate-1- 13C is the 13C labeled Sodium 2-Methylpropionate .
|
-
- HY-Y0989S3
-
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Acetophenone- 13C is the 13C labeled Acetophenone . Acetophenone is an organic compound with simple structure .
|
-
- HY-W777148
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Anagrelide- 13C3 (BL 4162A- 13C3) is 13C labeled Anagrelide .
|
-
- HY-W010392S1
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Ethyl 2-methylbutanoate- 13C2 is 13C labeled Ethyl 2-methylbutanoate.
|
-
- HY-W110705S
-
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|
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1-Bromopentadecane-1- 13C is the 13C labeled 1-Bromopentadecane .
|
-
- HY-W654058
-
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|
L-Arginine- 13C,d4 (dihydrochloride) is 13C labeled L-Arginine (dihydrochloride) .
|
-
- HY-N0378S6
-
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D-Mannitol- 13C,d2 is the deuterium and 13C labeled D-Mannitol.
|
-
- HY-W014633S1
-
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4-(Trifluoromethoxy)benzoic acid- 13C is the 13C labeled 4-(Trifluoromethoxy)benzoic acid .
|
-
- HY-146986S1
-
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N-acetyl-D-talosamine- 13C is the 13C labeled N-acetyl-D-talosamine .
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-
- HY-W009204S2
-
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Fmoc-Ala-OH-1- 13C is the 13C labeled Fmoc-Ala-OH .
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-
- HY-41121S
-
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Boc-Ala-OH-1- 13C is the 13C labeled Boc-Ala-OH .
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-
- HY-W012932S
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2,4-Dimethylthiazole- 13C3 is 13C labeled 2,4-Dimethylthiazole.
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-
- HY-N2325S
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D-(+)-Cellobiose- 13C is the 13C labeled D-(+)-Cellobiose. D-(+)-Cellobiose is an endogenous metabolite .
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-
- HY-150678S
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Adenosine:H20- 13C is the 13C labeled Adenosine:H20 .
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-
- HY-B0141S7
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rel-Estradiol- 13C6 is the sup>13C-labeled rel-Estradiol .
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-
- HY-W088065S1
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Sodium formate- 13C,d1 is the deuterium and 13C labeled Sodium formate[1].
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-
- HY-A0084S1
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Procainamide- 13C2 hydrochloride is 13C labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.
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-
- HY-Y1069S3
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(S)-Malic acid- 13C4 is the 13C labeled S-Malic acid (HY-Y1069) .
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-
- HY-152039S1
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6PPD-quinone- 13C6 is the 13C labeled 6PPD-quinone .
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-
- HY-W015198S
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4-(Trifluoromethyl)benzoic acid- 13C6 is the 13C labeled 4-(Trifluoromethyl)benzoic acid .
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-
- HY-W338294S1
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2'-Deoxycytidine- 13C-2 (monohydrate) Monohydrate is the 13C labeled 2'-Deoxycytidine .
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-
- HY-W009362AS
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DL-Isocitric acid-13C4 (trisodium hydrate) is a 13C labeled DL-Isocitric acid.
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-
- HY-N0294S1
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Protocatechuic acid- 13C7 is 13C labeled Protocatechuic acid. Protocatechuic acid is a phenolic compound which exhibits neuroprotective effect.
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-
- HY-W012507S1
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2,6-Dichlorobenzoic acid- 13C6 is 13C labeled 2,6-Dichlorobenzoic acid .
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-
- HY-143778S
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Clavulanic acid methyl ester- 13C,d3 is the deuterium and 13C labeled Clavulanic acid methyl ester .
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-
- HY-W091039S
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N-Acetyl-α-neuraminic acid- 13C3 is the 13C labeled N-Acetyl-α-neuraminic acid .
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-
- HY-W769279
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Felodipine- 13C4,d3 is 13C labeled Felodipine .
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-
- HY-121259S
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Doxorubicinol- 13C,d3 (TFA) is the deuterium and 13C labeled Doxorubicinol TFA .
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-
- HY-166923S
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2-Chloro dibenzofuran- 13C12 is 13C labeled 2-Chloro dibenzofuran .
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-
- HY-W654127
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Cytarabine- 13C3 5'-monophosphate is 13C labeled Cytarabine 5’-monophosphate .
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- HY-B0111RS
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Drospirenone- 13C3 is 13C labeled Drospirenone. Drospirenone (Dihydrospirorenone) is a synthetic progesterone that is an analog of Spironolactone .
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- HY-141907S
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17β-Estradiol- 13C3 is the 13C labeled 17β-Estradiol .
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-
- HY-B1732S1
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DL-3-Phenylalanine- 13C is the 13C labeled DL-3-Phenylalanine .
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-
- HY-114364S
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UDP-α-D-Galactose- 13C (disodium) is the 13C labeled UDP-α-D-Galactose disodium salt .
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-
- HY-W020678S
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2-Methylbutanal- 13C6 is 13C labeled 2-Methylbutanal (HY-W020678).
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-
- HY-W039909S
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Tri-O-acetyl-D-galactal- 13C is the 13C labeled Tri-O-Acetyl-D-galactose .
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-
- HY-W198678S
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6-Methylthioguanine- 13C,d3 is the 13C labeled 6-Methylthioguanine .
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-
- HY-W001942S2
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DL-2-Methylbutyric acid- 13C2 is 13C labeled DL-2-Methylbutyric acid.
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-
- HY-B1659S
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Glycerol- 13C3,d8 is the deuterium and 13C labeled Glycerol .
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-
- HY-W017072S
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1-Dodecene-1,2- 13C2 is the 13C labeled 1-Dodecene .
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-
- HY-Y0781S1
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Pyruvic acid- 13C is the 13C labeled Pyruvic acid . Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
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-
- HY-W715199S
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Pentabromo benzene- 13C6 is 13C labeled 1,2,3,4,5-Pentabromobenzene .
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-
- HY-150628S
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2-Oxobutanoic acid- 13C,d1 sodium hydrate is the deuterium and 13C labeled 2-Oxobutanoic acid sodium hydrate.
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-
- HY-W768347
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Xylitol- 13C5 (Xylite- 13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .
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- HY-143683S
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Theophylline- 13C2,d6 (1,3-Dimethylxanthine- 13C2,d6) is the deuterium labeled and 13C-labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .
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-
- HY-W765177
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Acetyl-L-carnitine hydrochloride- 13C3 (O-Acetyl-L-carnitine hydrochloride- 13C3) is the 13C-labeled Acetyl-L-carnitine hydrochloride (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression .
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- HY-141637S1
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2-Deoxy-2-fluoro-D-glucose- 13C,d7 is the 13C-labeled and deuterium labeled 2-Deoxy-2-fluoro-D-glucose (HY-141637) . 2-Deoxy-2-fluoro-D-glucose, a radiolabeled glucose analog, is commonly used in medical imaging techniques such as positron emission tomography (PET) scans. FDG has unique chemical properties that allow it to be taken up by cells that actively metabolize glucose, such as cancer cells or inflamed tissue. Once absorbed, FDG emits positrons that can be detected in 2-Deoxy-2-fluoro-D-glucose scans, producing images that highlight areas of high metabolic activity in the body. This makes it a useful tool for diagnosing and monitoring a variety of diseases, including cancer and neurological disorders.
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-
- HY-128753S4
-
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D-Lyxose- 13C-3 is the 13C labeled D-Lyxose. D-Lyxose is an endogenous metabolite .
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-
- HY-W005355S7
-
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Sodium 2-oxobutanoate- 13C,d2 is the deuterium and 13C labeled Sodium 2-oxobutanoate .
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-
- HY-166909S
-
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1,4,5-Trichloronaphthalene- 13C10 is 13C labeled 1,4,5-Trichloronaphthalene .
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-
- HY-128753S3
-
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D-Lyxose- 13C-2 is the 13C labeled D-Lyxose. D-Lyxose is an endogenous metabolite .
|
-
- HY-N0086S1
-
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N6-Methyladenosine- 13C is the 13C labeled isotope of N6-Methyladenosine .
|
-
- HY-128790S
-
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4-Methoxyestrone- 13C,d3 is the deuterium and 13C labeled 4-Methoxyestrone .
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-
- HY-141934S
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2-Methylthiopurine- 13C,d3 is the deuterium and 13C labeled 2-Methylthiopurine .
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-
- HY-Y0442S
-
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2-Methylbenzaldehyde- 13C is the 13C labeled 2-Methylbenzaldehyde . 2-Methylbenzaldehyde is an endogenous metabolite.
|
-
- HY-W746828
-
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Oxindole-3-acetic acid- 13C6 is 13C labeled Oxindole-3-acetic acid .
|
-
- HY-W654126
-
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Cytarabine- 13C3 (Cytosine β-D-arabinofuranoside- 13C3) is 13C labeled Cytarabine .
|
-
- HY-166962S
-
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2,3-Dichloro dibenzofuran- 13C12 is 13C labeled 2,3-Dichloro dibenzofuran .
|
-
- HY-W778144
-
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O,O-Diethyl Thiophosphate- 13C4 (ammonium) is 13C labeled O,O-Diethyl Thiophosphate (ammonium) .
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-
- HY-128741S2
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D-Allose- 13C-2 is the 13C labeled D-Allose. D-Allose is an endogenous metabolite .
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-
- HY-B2221S4
-
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U-13C Cellulose high DP from maize (high purity) is the 13C labeled Cellulose .
|
-
- HY-128753S5
-
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D-Lyxose- 13C-4 is the 13C labeled D-Lyxose. D-Lyxose is an endogenous metabolite .
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-
- HY-128741S1
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D-Allose- 13C-1 is the 13C labeled D-Allose. D-Allose is an endogenous metabolite .
|
-
- HY-16561S2
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Resveratrol-(4-Hydroxyphenyl)- 13CN6 is the 13C labeled Resveratrol-(4-Hydroxyphenyl) .
|
-
- HY-W357090S
-
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L-Idose- 13C-3 is the 13C labeled L-Idose (HY-W357090) .
|
-
- HY-W777577
-
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ent-Calindol Hydrochloride- 13C,d2 is the deuterium and 13C labeled (S)-Calindol hydrochloride (HY-122819A).
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- HY-W005355S8
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Sodium 2-oxobutanoate- 13C,d4 is the deuterium and 13C labeled Sodium 2-oxobutanoate .
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-
- HY-143843S
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Isosorbide-2-mononitrate- 13C6 is the 13C labeled Isosorbide-2-mononitrate .
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- HY-150533S
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(E/Z)-Mycophenolic Acid- 13C,d3 is the deuterium and 13C labeled (E/Z)-Mycophenolic Acid .
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- HY-76929S
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tert-Butyl 4-aminobenzoate- 13C6 is the 13C labeled tert-Butyl 4-aminobenzoate .
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- HY-W617979S
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3,4-Dichlorodiphenyl ether- 13C12 is 13C labeled 3,4-Dichlorodiphenyl ether .
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- HY-150706S
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D-fructose-6-phosphate- 13C6 is the 13C labeled D-fructose-6-phosphate .
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- HY-33212S
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D-N-Acetylgalactosamine- 13C is the 13C labeled D-N-Acetylgalactosamine. D-N-Acetylgalactosamine is an endogenous metabolite .
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-
- HY-W097453S
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6-(Methylthio)purine- 13C,d3 is the 13C labeled 6-(Methylthio)purine.
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- HY-W777535
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Naphthalene- 13C10 is 13C labeled Naphthalene-13C10 (HY-W777535).
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-
- HY-W777581
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4-tert-Octylphenol-diethoxylate- 13C6 is the 13C labeled isotope of 4-tert-Octylphenol-diethoxylate .
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- HY-W777535S
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Naphthalene- 13C6 is 13C labeled Naphthalene-13C10 (HY-W777535).
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-
- HY-W094748S1
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Dibenzo-p-dioxin- 13C12 is 13C labeled Dibenzo[b,e][1,4]dioxin .
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-
- HY-15926S
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ONPG- 13C is the 13C labeled ONPG. ONPG is a colorimetric and spectrophotometric substrate for detection of β-galactosidase activit .
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- HY-79131S5
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Fmoc-Phe-OH- 13C is the 13C labeled Fmoc-Phe-OH . Fmoc-Phe-OH is a phenylalanine derivative .
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- HY-B1640S
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Ethacrynic acid-13C2,d5 is the deuterium and 13C labeled Ethacrynic acid .
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- HY-146993S
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3-O-Methyl-D-glucose- 13C is the 13C labeled 3-O-Methyl-D-glucose .
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-
- HY-W092778S
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4,4′-Dibromo diphenyl ether- 13C12 is 13C labeled 4,4'-Oxybis(bromobenzene) .
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- HY-B0389S
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D-Glucose- 13C6,d7 is the deuterium and 13C labeled D-Glucose .
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- HY-W102356S1
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Phenethyl acetate- 13C2 is 13C labeled Phenethyl acetate (HY-W102356). Phenethyl acetate (Phenethyl alcohol) is a natural product .
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- HY-W778148
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O,O-Diethyl dithiophosphate- 13C4 ammonium is the 13C labeled isotope of O,O-Diethyl dithiophosphate ammonium .
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- HY-W585982S
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Bisphenol A β-D-Glucuronide- 13C12 is the 13C labeled isotope of Bisphenol A β-D-Glucuronide .
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- HY-W778154
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O,O-Dimethyl dithiophosphate- 13C2 ammonium is the 13C labeled isotope of O,O-Dimethyl dithiophosphate ammonium .
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- HY-N7092S1
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D-Fructose- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
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- HY-146992S
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α-D-Glucopyranosyl 1-phosphate- 13C (dicyclohexylamine, monohydrate) is the 13C labeled α-D-Glucopyranosyl 1-phosphate .
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- HY-166915S
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1,4,6-Trichloro naphthalene- 13C10 is 13C labeled 1,4,6-Trichloro naphthalene .
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- HY-W010256S
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D-Xylulose-1- 13C is the 13C labeled D-Xylulose. D-xylulose is a precursor of the pentiol D-arabi .
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- HY-W770295
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2,3,4,5-Tetrabromobenzoic acid- 13C6 is 13C labeled 2,3,4,5-Tetrabromobenzoic acid .
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- HY-W673588S
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2,3-Dichlorobiphenyl- 13C12 is 13C labeled 1,1'-Biphenyl, 2,3-Dichloro- .
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- HY-W013058S
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1,2-Bis(pentabromophenyl)ethane- 13C14 is 13C labeled 1,2-Bis(perbromophenyl)ethane .
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- HY-W010256S3
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D-Xylulose-13C5 is 13C labeled D-Xylulose. D-xylulose is the precursor of arabinitol .
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- HY-Z2483S
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Clopidogrel-MP endo derivative- 13C,d3 is the deuterium and 13C labeled Clopidogrel-MP endo derivative .
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- HY-Y0781S3
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Pyruvic acid- 13C-2 (sodium) is the 13C labeled Pyruvic acid . Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
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- HY-Y0504S
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Trimethylammonium chloride- 13C3,d9 is the deuterium and 13C labeled Trimethylammonium chloride . Trimethylammonium chloride is an endogenous metabolite.
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- HY-13553S1
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Anidulafungin- 13C6 (LY303366- 13C6) is 13C labeled Anidulafungin. Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
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- HY-W039909S1
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Tri-O-acetyl-D-galactal- 13C-1 is the 13C labeled Tri-O-Acetyl-D-galactose .
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- HY-W779345
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3,3',5'-Triiodo-L-thyronine- 13C6 is 13C labeled 3,3',5'-Triiodo-L-thyronine .
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- HY-W327895S
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Tris(4-chlorophenyl)methanol- 13C19 is 13C labeled Tris(4-chlorophenyl)methanol .
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- HY-76595S1
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4-Bromo diphenyl ether- 13C12 is 13C labeled 1-Bromo-4-phenoxybenzene .
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- HY-138199S
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Omeprazole sulfone N-oxide- 13C,d3 is the deuterium and 13C labeled Omeprazole sulfone N-Oxide .
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- HY-W012980S1
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Isovaleric acid- 13C is the 13C labeled Isovaleric acid. Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.
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- HY-B1732S3
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DL-3-Phenylalanine- 13C-1 is the 13C labeled DL-3-Phenylalanine .
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- HY-G0007S1
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Omeprazole metabolite Omeprazole sulfone- 13C,d3 is the deuterium and 13C labeled Omeprazole metabolite Omeprazole sulfone .
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- HY-W010256S1
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D-Xylulose-2- 13C is the 13C labeled D-Xylulose. D-xylulose is a precursor of the pentiol D-arabi .
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- HY-W011873S2
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Palmitoleic acid- 13C16 is the 13C labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.
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- HY-166959S
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2,3,8-Trichloro dibenzofuran- 13C12 is 13C labeled 2,3,8-Trichloro dibenzofuran .
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- HY-W549233S
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Tris(4-chlorophenyl)methane- 13C19 is 13C labeled Tris(4-chlorophenyl)methane .
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- HY-W012684S
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Ethane-1,2-diamine dihydrochloride- 13C2 is the 13C labeled Ethane-1,2-diamine dihydrochloride .
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- HY-103395S1
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Methylmalonic acid- 13C4 is the 13C labeled Methylmalonic acid . Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer .
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- HY-W013378S4
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Carbamazepine 10,11-epoxide- 13C is the 13C labeled Carbamazepine 10,11-epoxide (HY-W013378) .
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- HY-N7092S
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D-Fructose- 13C6 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
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- HY-W012722BS1
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4-Methyl-2-oxopentanoic acid- 13C (sodium) is the 13C labeled 4-Methyl-2-oxopentanoic acid sodium .
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- HY-W749012
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(2,4,6-Trichlorophenoxy)acetic acid- 13C6 is the 13C labeled isotope of (2,4,6-Trichlorophenoxy)acetic acid .
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- HY-50719S1
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2-Acetyl-1-pyrroline- 13C5 is 13C labeled 2-Acetyl-1-pyrroline.
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- HY-128417S1
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Alpha-D-glucose- 13C is the 13C labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite .
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- HY-B1659S1
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Glycerol- 13C is the 13C labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis .
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- HY-W747097
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Sacubitrilat- 13C4 (Desethyl Sacubitril- 13C4) is 13C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
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- HY-W005355S
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Sodium 2-oxobutanoate- 13C4,d2 (hydrate) is the deuterium and 13C labeled Sodium 2-oxobutanoate hydrate .
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- HY-W014632S
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4-Trifluoromethylsalicylic acid- 13C6 is the 13C labeled 4-Trifluoromethylsalicylic acid . 4-Trifluoromethylsalicylic acid is a platelet aggregation inhibitor .
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- HY-W008507S
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(R)-2,3-Dihydroxypropanal-3- 13C is the 13C labeled (R)-2,3-Dihydroxypropanal .
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-
- HY-W654082
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Bisphenol e- 13C6 is 13C labeled Bisphenol E. Bisphenol E (4,4'-Ethylidenediphenol) is a biochemical reagent .
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- HY-W585890S
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Benzo[pqr]tetraphen-3-ol- 13C6 is 13C labeled Benzo[pqr]tetraphen-3-ol.
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- HY-N7092S3
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D-Fructose- 13C2 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
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- HY-B0375S1
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Argatroban- 13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.
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- HY-W012578S1
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2-Isopropyl-3-methoxypyrazine- 13C3 is 13C labeled 2-Isopropyl-3-methoxypyrazine.
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- HY-I0960S2
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Uracil- 13C is the 13C labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .
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- HY-Y0418S
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Dulcite- 13C is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact .
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- HY-157386S
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8-(o-Fluoro-benzyl)theophylline methylsulfonyl- 13C2 is a 13C labeled 8-(o-Fluoro-benzyl)theophylline methylsulfonyl.
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- HY-W013812S
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Ethyl linoleate- 13C18 is the 13C labeled Ethyl linoleate. Ethyl linoleate inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators .
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- HY-W703429S
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2,3,6,7-Tetrachloro-naphthalene- 13C10 is 13C labeled 2,3,6,7-Tetrachloronaphthalene .
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- HY-Y1117S1
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Melamine- 13C3 is the 13C labeled Melamine . Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials .
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- HY-W005355S10
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Sodium 2-oxobutanoate- 13C4,d2 is the deuterium and 13C labeled Sodium 2-oxobutanoate .
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- HY-N0733S
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Glucosamine- 13C (hydrochloride) is the 13C labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a
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- HY-166917S
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1,3,6,8-Tetrachloro-dibenzofuran- 13C12 is 13C labeled 1,3,6,8-Tetrachlorodibenzofuran .
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- HY-W754811
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Trifluoroacetic acid-13C sodium is the 13C labeled isotope of Trifluoroacetic acid-13C (sodium) (HY-W754811) .
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- HY-B1659S5
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Glycerol- 13C3 is the 13C labeled Glycerol . Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis .
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- HY-W017049S
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Trifluoroacetic acid-13C2 sodium is the 13C labeled isotope of Sodium 2,2,2-trifluoroacetate (HY-W017049) .
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- HY-141919S
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1-Bromo-4-iodobenzene- 13C6 is the 13C labeled 1-Bromo-4-iodobenzene .
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- HY-N3686S
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D-Arabitol- 13C is the 13C labeled D-Arabitol. D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in hu .
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- HY-150629S
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2-Ketobutyric acid- 13C4,3,3-d2 sodium salt hydrate is the 13C labeled 2-Ketobutyric acid sodium salt hydrate .
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- HY-N0210S12
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D-Galactose- 13C,d is the deuterium and 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-166918S
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2,3,6,7-Tetrachloro biphenylene- 13C12 is 13C labeled 2,3,6,7-Tetrachloro biphenylene .
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- HY-N0666S
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L-Aspartic acid- 13C is a 13C labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly .
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- HY-I0960S1
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Uracil- 13C4 is the 13C labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .
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- HY-Y0781S5
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Pyruvic acid- 13C,d4 is the deuterium and 13C labeled Pyruvic acid . Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats .
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- HY-B1659S4
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Glycerol- 13C2 is the 13C labeled Glycerol . Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis .
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- HY-W010489S1
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2-Phenylacetaldehyde- 13C2 is 13C labeled 2-Phenylacetaldehyde (HY-W010489). 2-Phenylacetaldehyde is an endogenous metabolite.
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- HY-B1462S1
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Chlorzoxazone- 13C is the 13C labeled Chlorzoxazone . Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort .
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-
- HY-113143AS
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Galactose 1-phosphate- 13C (potassium) is the 13C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug .
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- HY-166903S
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2,3,4,5-Tetrachlorodiphenyl ether- 13C12 is 13C labeled 2,3,4,5-Tetrachlorodiphenyl ether .
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- HY-166900S
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3,3′,4,5′-Tetrabromodiphenyl ether- 13C12 is 13C labeled 3,3′,4,5′-Tetrabromodiphenyl ether .
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- HY-W097410S1
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2-Iodo-N-phenylacetamide- 13C6 (N-phenyliodoacetamide- 13C6) is the 13C labeled 2-Iodo-N-phenylacetamide.
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- HY-166963S
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3,4,4′-Trichloro diphenyl ether- 13C12 is 13C labeled 3,4,4′-Trichloro diphenyl ether .
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- HY-W010388S
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Creatine- 13C is the 13C labeled Creatine . Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain .
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- HY-139312S
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L-Mannitol-1- 13C is the 13C labeled L-Mannitol. L-mannitol is a compound?can be used for ?the compound sweetener synthesis .
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-
- HY-W718472S
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3,3′-Dichloro biphenyl- 13C12 is 13C labeled 3,3'-Dichloro-1,1'-biphenyl .
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-
- HY-W152813S
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3',4'-Dichloro-4-biphenylol- 13C12 is 13C labeled 4-(3,4-Dichlorophenyl)phenol .
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- HY-113008S1
-
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Urocanic acid- 13C3 is the 13C labeled Urocanic acid . Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR) .
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- HY-N7092S7
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D-Fructose-6- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants .
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- HY-146989S
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4-O-β-D-Galactopyranosyl-D-mannose- 13C is the 13C labeled 4-O-β-D-Galactopyranosyl-D-mannose .
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- HY-N0105S2
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Rhein- 13C4 (Rheic Acid- 13C4) is 13C labeled Rhein. Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects .
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- HY-N7092S2
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D-Fructose- 13C-1 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
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- HY-N0733S3
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Glucosamine-6- 13C (hydrochloride) is the 13C labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as
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- HY-N7092S5
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D-Fructose-4- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants .
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-
- HY-N0378S2
-
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D-Mannitol- 13C6 is the 13C labeled D-Mannitol . D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator .
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-
- HY-W007928S
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1-O-Acetyl 2,3,5-tri-O-benzoyl-beta-D-ribofuranoside- 13C is the 13C labeled D-Ribulose .
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-
- HY-150525S
-
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Acetyl-1,2 Coenzyme A- 13C2(Lithium) is the 13C labeled Acetyl-1,2 Coenzyme A Lithium .
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- HY-23506S
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1-Aminoimidazolidine-2,4-dione- 13C3 is 13C labeled 1-Aminoimidazolidine-2,4-dione.
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-
- HY-W654080
-
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Bisphenol P- 13C4 is 13C labeled α,α'-Bis(4-hydroxyphenyl)-1,4-diisopropylbenzene .
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-
- HY-154814S
-
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Monohydroxy-3-butenyl-mercapturic acid- 13C3, 15N sodium is 15N and 13C labeled Monohydroxy-3-butenyl-mercapturic acid.
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-
- HY-N0733S1
-
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Glucosamine-2- 13C (hydrochloride) is the 13C labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as
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-
- HY-Y0287AS
-
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Calcium carbonate,99.8%,PT- 13C is the 13C labeled Calcium carbonate,99.95-100.05%,PT .
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-
- HY-N7092S4
-
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D-Fructose-3- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants .
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-
- HY-100043S
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2-Ethyl-3,5-dimethylpyrazine- 13C2 is 13C labeled 2-Ethyl-3,5-dimethylpyrazine.
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-
- HY-154746S
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3-HPMA Potassium Salt-3- 13C3, 15N is 15N and 13C labeled 3-HPMA Potassium Salt-3.
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-
- HY-W765043
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4-Methoxy Fenretinide- 13C,d3 is the deuterium and 13C labeled 4-Methoxy Fenretinide (HY-W776976).
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-
- HY-N1420AS
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Rhamnose- 13C (monohydrate) is the 13C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate c
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- HY-N0210S
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D-Galactose- 13C is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
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-
- HY-N7092S6
-
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D-Fructose-5- 13C is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants .
|
-
- HY-W777457
-
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Anthracene- 13C6 (Anthracin- 13C6) is 13C labeled Anthracene-13C6 (HY-W777457).
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- HY-100805S2
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D-Glutamic acid- 13C5 ((R)-Glutamic acid- 13C5) is 13C labeled D-Glutamic acid. D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.
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- HY-W015604S
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2,3-Diethyl-5-methylpyrazine- 13C2 is 13C labeled 2,3-Diethyl-5-methylpyrazine.
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- HY-113263S1
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17α-Hydroxypregnenolone- 13C2,d2 is the deuterium and 13C labeled 17α-Hydroxypregnenolone .
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- HY-W013378S5
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Carbamazepine 10,11-epoxide- 13C-1 is the 13C labeled Carbamazepine 10,11-epoxide (HY-W013378) .
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- HY-B2219S
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Stearic acid-1- 13C is the 13C labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
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- HY-127035S1
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Tristearin- 13C3 (Glycerol tristearate- 13C3) is 13C labeled Tristearin. Tristearin is a triglyceride derived from three units of stearic acid .
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- HY-W748322
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1, 2, 3, 4, 7, 8- Hexachloro-dibenzofuran- 13C12 is 13C labeled 1,2,3,4,7,8-Hexachlorodibenzofuran .
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- HY-166895S
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1,3,4,6,8-Pentachloro dibenzofuran- 13C12 is 13C labeled 1,3,4,6,8-Pentachloro dibenzofuran .
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- HY-Y0418S3
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Dulcite- 13C-3 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact .
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- HY-W010042S
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L-Glucose- 13C is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake .
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- HY-W715361S
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2,4,6,8-Tetrachloro dibenzothiophene- 13C12 is 13C labeled 2,4,6,8-Tetrachlorodibenzo[b,d]thiophene .
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- HY-W104549S
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3,6-Dichloro-2-hydroxybenzoic acid- 13C6 is the 13C labeled 3,6-Dichloro-2-hydroxybenzoic acid .
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- HY-166920S
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2,2′,3,4,5-Pentachlorodiphenyl ether- 13C12 is 13C labeled 2,2′,3,4,5-Pentachlorodiphenyl ether .
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- HY-Y0418S1
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Dulcite- 13C-1 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact .
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- HY-B0892S5
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Benzyl alcohol- 13C is the 13C labeled Benzyl alcohol (HY-B0892). Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor .
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- HY-166933S
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1,2,3,6,7-Pentachloro-naphthalene- 13C10 is 13C labeled 1,2,3,6,7-Pentachloro-naphthalene .
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- HY-166893S
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1,2,3,6,7,8-Hexachloronaphthalene- 13C10 is 13C labeled 1,2,3,6,7,8-Hexachloronaphthalene .
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- HY-Y0418S2
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Dulcite- 13C-2 is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact .
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- HY-166897S
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1,2,3,4,8,9-Hexachlorodibenzofuran- 13C12 is 13C labeled 1,2,3,4,8,9-Hexachlorodibenzofuran .
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- HY-166957S
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1,2,3,7,8-Pentachloro naphthalene- 13C10 is 13C labeled 1,2,3,7,8-Pentachloro naphthalene .
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- HY-166924S
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1,2,3,4,6-Pentachloro-dibenzofuran- 13C12 is 13C labeled 1,2,3,4,6-Pentachloro-dibenzofuran .
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- HY-166948S
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1,2,3,8,9-Pentachloro dibenzofuran- 13C12 is 13C labeled 1,2,3,8,9-Pentachloro dibenzofuran .
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- HY-W766368
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C6 Ceramide- 13C2,d2 (C6-Cer- 13C2,d2) is the deuterium labeled and 13C-labeled C6 Ceramide (HY-19542). C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .
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- HY-42682S1
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D(+)-Galactosamine- 13C (hydrochloride) is the 13C labeled D(+)-Galactosamine hydrochloride. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and
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- HY-W762012S
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Octachlorodibenzo-p-dioxin- 13C12 is Octachlorodibenzo-p-dioxin- 13 C-labeled octachlorodibenzo-p-dioxin- 13C. Octachlorodibenzo-p-dioxin is a widespread environmental pollutant .
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- HY-113143AS1
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Galactose 1-phosphate- 13C-1 (potassium) is the 13C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug .
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- HY-N0658S6
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L-Threonine- 13C4 is the 13C labeled L-Threonine . L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed .
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- HY-W009444S4
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5-Methyluridine-5′- 13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu .
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- HY-150660S
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25-Hydroxyvitamin D2-(20,21,22,26,27- 13C5) solution is the 13C labeled 25-Hydroxyvitamin D2 .
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- HY-N3686S1
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D-Arabitol- 13C-1 is the 13C labeled D-Arabitol. D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in hu .
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- HY-N0379S5
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D-Mannose- 13C is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-N3686S2
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D-Arabitol- 13C-2 is the 13C labeled D-Arabitol. D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in hu .
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- HY-W009444S1
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5-Methyluridine-1′- 13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu .
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- HY-10353AS1
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Raltegravir- 13C,d3 potassium is 13C labeled Raltegravir potassium (HY-10353A). Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.
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- HY-118877
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1 Publications Verification
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Urea- 13C is the 13C labelled urea. The Urea- 13C breath test ( 13C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection .
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- HY-141637S
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2-Deoxy-2-fluoro-D-glucose- 13C is the 13C labeled 2-Deoxy-2-fluoro-D-glucose .
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- HY-W653994
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Ethyl Paraben- 13C6 (Ethyl parahydroxybenzoate- 13C6) is 13C labeled Ethylparaben. Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive .
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- HY-W715357S
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3,3′,4,4′-Tetrabromo diphenyl ether- 13C12 is 13C labeled 4,4'-Oxybis(1,2-dibromobenzene) .
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- HY-41417S3
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Octanoic acid- 13C is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
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- HY-N10004S
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1-Deoxy-1-L-proline-D-fructose- 13C6 is 13C labeled 1-Deoxy-1-L-proline-D-fructose.
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- HY-W715351S
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1,2,4,5,7,8-Hexachloro naphthalene- 13C10 is 13C labeled 1,2,4,5,7,8-Hexachloronaphthalene .
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- HY-113075S
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1,5-Anhydrosorbitol- 13C is the 13C labeled 1,5-Anhydrosorbitol. 1,5-Anhydrosorbitol is a short-term marker for glycemic cont .
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- HY-W009444S2
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5-Methyluridine-2′- 13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu .
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- HY-W010184S
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4,6-Dioxoheptanoic acid- 13C5 is the 13C labeled 4,6-Dioxoheptanoic acid . 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis .
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- HY-146990S
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3-Deoxy-3-fluoro-D-glucose- 13C is the 13C labeled 3-Deoxy-3-fluoro-D-glucose .
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- HY-W009444S3
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5-Methyluridine-3′- 13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu .
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- HY-W751145
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Diphenyl ether- 13C12 is 13C labeled Diphenyl ether. Oxydibenzene is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-34628S
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3,4,6-Tri-O-acetyl-D-glucal- 13C is the 13C labeled 3,4,6-Tri-O-acetyl-D-glucal .
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- HY-14164S1
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Zileuton- 13C2, 15N is 15N and 13C labeled Zileuton (HY-14164). Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
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- HY-143784S
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C14 Benzalkonium-1 acid- 13C2,d11 (chloride) is the deuterium and 13C labeled C14 Benzalkonium-1 acid chloride .
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- HY-N1420AS2
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Rhamnose- 13C-2 (monohydrate) is the 13C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate
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- HY-B1659S2
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Glycerol- 13C-1 (90% in water) is the 13C labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis .
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- HY-W552229S
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2,8-Dichloro dibenzo-p-dioxin- 13C12 is 13C labeled 2,8-Dichlorodibenzo[b,e][1,4]dioxine .
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- HY-N0210S3
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D-Galactose- 13C-4 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
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- HY-150661S
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3-Epi-25-hydroxyvitamin D3- 13C5 is the 13C labeled 3-Epi-25-hydroxyvitamin D3 .
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- HY-W718518S
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2,3,4,4′-Tetrachloro biphenyl- 13C12 is 13C labeled 2,3,4,4'-Tetrachloro-1,1'-biphenyl .
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- HY-W243408S
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Calcium carbonate-13C (Limestone-13C) is the 13C labeled isotope of Calcium carbonate,50nm (HY-W243408) .
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- HY-B0482S1
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Acemetacin- 13C6 (TVX 1322- 13C6) is 13C labeled Acemetacin. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
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- HY-W767866
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N-Acetyl-S-(2-carboxyethyl)cysteine- 13C3 (dicyclohexylamine) is 13C labeled N-Acetyl-S-(2-carboxyethyl)cysteine (dicyclohexylamine) .
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- HY-N0210S1
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D-Galactose- 13C-2 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
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- HY-W748327
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2,5-Dichloro-1,1'-biphenyl- 13C12 is 13C labeled 2,5-Dichloro-1,1'-biphenyl .
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- HY-W654041
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Adenosine monophosphate- 13C5 (AMP- 13C5) is 13C labeled Adenosine monophosphate. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction .
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- HY-166904S
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2,2′,4,4′,6-Pentabromo diphenyl ether- 13C12 is 13C labeled 2,2′,4,4′,6-Pentabromo diphenyl ether .
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- HY-W654343
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D-Erythro-sphingosine-1-phosphate- 13C2,d2 is 13C labeled D-Erythro-sphingosine-1-phosphate .
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- HY-23805S
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3,6-Dichloro-9H-carbazole- 13C12 is 13C labeled 3,6-Dichloro-9H-carbazole .
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- HY-N2041S4
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Myristic acid- 13C3 is the 13C labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
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- HY-106950S1
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Fosfructose- 13C6 (tetrasodium hydrate) is the 13C labeled Fosfructose (HY-106950). Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma .
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- HY-W009597S
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1,5-Dichloro-2,4-dinitrobenzene- 13C6 is the 13C labeled 1,5-Dichloro-2,4-dinitrobenzene .
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- HY-W718532S
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3,3′,4,5′-Tetrachloro biphenyl- 13C12 is 13C labeled 3,3',4,5'-Tetrachloro-1,1'-biphenyl .
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- HY-W294556S
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1-Benzyl-4-methylenepiperidine- 13C,d6 is the deuterium and 13C labeled 1-Benzyl-4-methylenepiperidine .
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- HY-W718525S
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2,3′,4′,5-Tetrachloro biphenyl- 13C12 is 13C labeled 2,3',4',5-Tetrachloro-1,1'-biphenyl .
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- HY-N0210S4
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D-Galactose- 13C-5 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
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- HY-W748303
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1, 2, 3, 7, 8, 9-Hexachloro-dibenzofuran- 13C12 is 13C labeled 1, 2, 3, 7, 8, 9-Hexachloro-dibenzofuran .
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- HY-41417S4
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Octanoic acid- 13C4 is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
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- HY-12767S2
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Carvedilol metabolite 4-Hydroxyphenyl Carvedilol- 13C6 (4-Hydroxycarvedilol Carvedilol- 13C6) is 13C labeled Carvedilol metabolite 4-Hydroxyphenyl Carvedilol.
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- HY-166927S
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2,2′,4,4′,5-Pentabromo diphenyl ether- 13C12 is 13C labeled 2,2′,4,4′,5-Pentabromo diphenyl ether .
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- HY-W770278
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Bisphenol Z-13C12 is the 13C labeled isotope of Bisphenol Z-13C12 (HY-W770278) .
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- HY-166961S
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2′,4′,5′-Trichloro-4-biphenylol- 13C12 is 13C labeled 2′,4′,5′-Trichloro-4-biphenylol .
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- HY-166949S
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1,2,8,9-Tetrachloro-dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,8,9-Tetrachloro-dibenzo-p-dioxin .
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- HY-N0210S2
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D-Galactose- 13C-3 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
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- HY-166912S
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1,2,3,5,6,7-Hexachloro-naphthalene- 13C10 is 13C labeled 1,2,3,5,6,7-Hexachloro-naphthalene .
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- HY-W748299
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1, 2, 3, 6, 7, 8-Hexachloro-dibenzofuran- 13C12 is 13C labeled 1, 2, 3, 6, 7, 8-Hexachloro-dibenzofuran .
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- HY-166936S
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1,2,3,4,5,6,8-Heptachloronaphthalene- 13C10 is 13C labeled 1,2,3,4,5,6,8-Heptachloronaphthalene .
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- HY-B0445S1
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NAD+- 13C5-1 is the 13C labeled NAD+ . NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
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- HY-W710384S
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1,2,3,4,5,6,7-Heptachloro naphthalene- 13C10 is 13C labeled 1,2,3,4,5,6,7-Heptachloronaphthalene .
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- HY-W654120
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Creatine- 13C3 is the 13C labeled isotope ofCreatine (HY-W010388) . Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.
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- HY-40354S3
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Tofacitinib- 13C (Tasocitinib- 13C) is 13C labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
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- HY-W006057AS
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Sodium 3-methyl-2-oxobutanoate- 13C2,d is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate .
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- HY-B0083S1
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Leflunomide- 13C6 (HWA486- 13C6) is 13C labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.
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- HY-W050145S2
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Levoglucosan- 13C6 is the 13C labeled Levoglucosan . Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature .
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- HY-B1431S1
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Butylparaben- 13C6 is the 13C labeled Butylparaben . Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.
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- HY-N1446S
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Oleic acid- 13C is the 13C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .
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- HY-N0172S
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Caffeic acid- 13C3 is an 13C labeled caffeic acid. Caffeic acid is a phytonutrient belonging to the flavonoids. Caffeic acid and its derivatives, are potential antimicrobial agents, chronic infection induced by microbes such as bacteria, fungi, and viruses .
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- HY-W715184S
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8-Bromo-2,3-dichlorodibenzofuran- 13C12 is 13C labeled 8-Bromo-2,3-dichlorodibenzo[b,d]furan .
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- HY-W748200
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3-Hydroxypropionic acid- 13C3 sodium is the 13C labeled 3-Hydroxypropionic acid sodium (HY-W095705A). 3-Hydroxypropionic acid sodium, an endogenous metabolite, is a building block in the chemical synthesis .
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- HY-79128S2
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Fmoc-L-Lys (Boc)-OH- 13C (Fmoc-L-Lys(Boc)-OH- 13C) is 13C labeled Fmoc-L-Lys (Boc)-OH. Fmoc-L-Lys (Boc)-OH is a lysine derivative .
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- HY-W779002
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alpha-D-glucose-13C2-1 is a 13C labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite[1].
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- HY-166670S
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Ketoconazole carbonyl- 13C (Ketoconazol- 13C) is 13C labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
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- HY-W010042S2
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L-Glucose- 13C-2 is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake .
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- HY-W010042S1
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L-Glucose- 13C-1 is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake .
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- HY-B1409S
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Isosorbide dinitrate- 13C6 is the 13C labeled Isosorbide dinitrate . Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) .
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- HY-W778057
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Ethyl 3,4-Dihydroxybenzoate- 13C3 (Protocatechuic acid ethyl ester- 13C3) is the 13C-labeled Ethyl 3,4-dihydroxybenzoate (HY-W016409). Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema .
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- HY-N1380S2
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Guaiacol- 13C6 is the 13C labeled Guaiacol . Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .
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- HY-166940S
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2′,3′,4′,5′-Tetrachloro-4-biphenylol- 13C12 is 13C labeled 2′,3′,4′,5′-Tetrachloro-4-biphenylol .
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- HY-N7125S
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Cinnamyl acetate- 13C2 is 13C labeled Cinnamyl acetate (HY-N7125). Cinnamyl acetate has a wide application in the flavor and fragrance industry . Cinnamyl acetate is a new broad spectrum antibacterial agent .
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- HY-B0158S1
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Cytidine- 13C is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine
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- HY-N0098S3
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Vanillin- 13C is the 13C labeled Vanillin . Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine .
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- HY-W778140
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Diethyl phosphate- 13C4 (sodium) is the 13C labeled isotope of Diethyl phosphate- 13C4 (sodium)(HY-101417).Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos .
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- HY-166894S
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3,3′,4,4′,5,5′-Hexabromo diphenyl ether- 13C12 is 13C labeled 3,3′,4,4′,5,5′-Hexabromo diphenyl ether .
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- HY-166899S
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1,3-Dibromo-2,7,8-trichlorodibenzofuran- 13C12 is 13C labeled 1,3-Dibromo-2,7,8-trichlorodibenzofuran .
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- HY-W354105S
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3,3',4,5,5'-Pentachloro biphenyl- 13C12 is 13C labeled 3,3',4,5,5'-Pentachloro-1,1'-biphenyl .
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- HY-W015883S2
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Fumaric acid- 13C2,d2 is the deuterium and 13C labeled Fumaric acid . Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite .
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- HY-W015410S
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Disodium succinate- 13C2 is the 13C labeled Disodium succinate . Disodium succinate is the disodium salt of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism .
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- HY-50667S
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Apixaban- 13C,d3 is a deuterium and 13C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively .
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- HY-166942S
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1,2,3,8,9-Pentachloro-dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,3,8,9-Pentachloro-dibenzo-p-dioxin .
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- HY-W749756
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rac-1,2-Distearoyl-3-chloropropanediol- 13C3 is 13C labeled rac-1,2-Distearoyl-3-chloropropanediol .
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- HY-N0379S7
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D-Mannose- 13C-2 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-166951S
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1,2,4,7,8-Pentachloro dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,4,7,8-Pentachloro dibenzo-p-dioxin .
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- HY-N0394S4
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L-Cystine-3,3'- 13C2 is the 13C labeled L-Cystine . L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes .
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- HY-166935S
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2,3-Dibromo-7,8-dichloro-dibenzofuran- 13C12 is 13C labeled 2,3-Dibromo-7,8-dichloro-dibenzofuran .
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- HY-N6725S
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Sterigmatocystine- 13C18 is 13C labeled 2,6-Dimethoxyphenol (HY-W003972). 2,6-Dimethoxyphenol is a phenolic compound that is extensively used for the measurement of laccase activity .
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- HY-76520S
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Sitaxsentan- 13C6 (IPI 1040- 13C6) is 13C labeled Sitaxsentan (HY-76520). Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist.
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- HY-34628S2
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3,4,6-Tri-O-acetyl-D-glucal- 13C-2 is the 13C labeled 3,4,6-Tri-O-acetyl-D-glucal .
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- HY-N0379S8
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D-Mannose- 13C-3 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-14832S1
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Ataluren- 13C6 (PTC124- 13C6) is 13C labeled Ataluren. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.
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- HY-W748314
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2,2',6-Trichloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',6-Trichloro-1,1'-biphenyl .
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- HY-N0379S9
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D-Mannose- 13C-4 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-166889S
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2,4,5-Trichloro-4'-methoxy-biphenyl- 13C12 is 13C labeled 2,4,5-Trichloro-4'-methoxy-biphenyl .
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- HY-166926S
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2,2′,3,4,5,5′-Hexachloro diphenyl ether- 13C12 is 13C labeled 2,2′,3,4,5,5′-Hexachloro diphenyl ether .
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- HY-N0305S2
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5-Aminolevulinic acid- 13C (hydrochloride) is the 13C labeled 5-Aminolevulinic acid hydrochloride . 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles .
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- HY-34628S1
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3,4,6-Tri-O-acetyl-D-glucal- 13C-1 is the 13C labeled 3,4,6-Tri-O-acetyl-D-glucal .
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- HY-N0379S6
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D-Mannose- 13C-1 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-N0379S10
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D-Mannose- 13C-5 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-41494S1
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o-Toluic acid- 13C is the 13C labeled o-Toluic acid . o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
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- HY-W748196S
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1,2,3,4,6,7-Hexachloro dibenzo-p-dioxin- 13C12 is 13C labeled 1, 2, 3, 4, 6, 7- Hexachlorodibenzo- p- dioxin .
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- HY-166950S
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2,2′,3,4,4′,6-Hexabromo diphenyl ether- 13C12 is 13C labeled 2,2′,3,4,4′,6-Hexabromo diphenyl ether .
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- HY-B1204S3
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Histamine- 13C5 is the 13C labeled Histamine (HY-B1204). Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter .
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- HY-N0379S14
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D-Mannose- 13C,d is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-N1446S2
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Oleic acid- 13C18 is the 13C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .
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- HY-100582S3
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Ribitol-5- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
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- HY-17359S1
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Deferasirox- 13C6 (ICL 670- 13C6) is 13C labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .
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- HY-150981S
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1,2-O-Isopropylidene-a-D-glucofuranuronic-6- 13C acid, γ-lactone is the 13C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid, γ-lactone .
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- HY-W400722
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Sodium 3-methyl-2-oxobutanoate- 13C5,d1 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate .
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- HY-N0098S2
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Vanillin- 13C6 is the 13C labeled Vanillin . Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine .
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- HY-165686
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Benalaxyl metabolite M2- 13C3 (N-(Carboxyacetyl)-N-(2,6-dimethylphenyl)-DL-alanine- 13C3) is 13C labeled Benalaxyl metabolite M2 .
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- HY-N6726S
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Fumonisin B3- 13C34 is the 13C labeled Fumonisin B3 (HY-N6726) . Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins .
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- HY-N7092S13
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D-Fructose- 13C6,d7 is the deuterium and 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants .
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- HY-W145492S2
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D-(+)-Talose- 13C is the 13C labeled D-(+)-Talose (HY-W145492) . D-(+)-Talose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-N2840S
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Allitol- 13C is the 13C labeled Allitol. Allitol is a rare natural polyol that can be used as a sweetener. Allitol is an important intermediate for the preparation of the agents which against diabetes, cancer, and viral infections, including AIDS
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- HY-100582S1
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Ribitol-2- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
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- HY-112537S2
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D-Glucose 6-phosphate-13C is 13C labeled D-Glucose 6-phosphate (HY-112537). D-Glucose 6-phosphate is glucose phosphorylated with a hydroxyl group on carbon 6 .
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- HY-W145584S
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D-Iditol- 13C is the 13C labeled D-Iditol. D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity .
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- HY-W718588S
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2,2',3,3',5,5'-Hexachlorobiphenyl- 13C12 is 13C labeled 2,2',3,3',5,5'-Hexachloro-1,1'-biphenyl .
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- HY-W006057AS3
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Sodium 3-methyl-2-oxobutanoate- 13C2,d4 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate .
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- HY-W006057AS2
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Sodium 3-methyl-2-oxobutanoate- 13C4,d4 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate .
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- HY-150980S
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1,2-O-Isopropylidene-β-L-idofuranuronic-6- 13C acid γ-lactone is the 13C labeled 1,2-O-Isopropylidene-β-L-idofuranuronic acid γ-lactone .
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- HY-N1480S
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(-)-Fucose- 13C is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti
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- HY-112174S
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UDP-GlcNAc- 13C (disodium) is the 13C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O .
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- HY-100582S2
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Ribitol-3- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol
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- HY-W777503
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Calindol hydrochloride- 13C,d2 is the deuterium and 13C labeled Calindol hydrochloride (HY-122819). Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM .
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- HY-N1446S4
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Oleic acid- 13C-1 is the 13C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .
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- HY-N0379S20
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D-Mannose- 13C,d-2 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-W718614S
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2,3,3′,4,5,5′-Hexachloro biphenyl- 13C12 is 13C labeled 2,3,3',4,5,5'-Hexachloro-1,1'-biphenyl .
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- HY-W748343
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2,2',5,5'-Tetrachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',5,5'-Tetrachloro-1,1'-biphenyl .
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- HY-166960S
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2,2′,4,4′-Tetrabromo-6-hydroxydiphenyl ether- 13C12 is 13C labeled 2,2′,4,4′-Tetrabromo-6-hydroxydiphenyl ether .
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- HY-166928S
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1,3,6,8-Tetrachloro-9H-carbazole- 13C12 is 13C labeled 1,3,6,8-Tetrachloro-9H-carbazole .
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- HY-B2167S2
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Docosahexaenoic acid- 13C4 is 13C labeled Docosahexaenoic acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk .
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- HY-W748290
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3,4,4',5-Tetrachloro-1,1'-biphenyl- 13C12 is 13C labeled 3,4,4',5-Tetrachloro-1,1'-biphenyl .
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- HY-111592S
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S-(5′-Adenosyl)-L-cysteine- 13C is the 13C labeled S-(5′-Adenosyl)-L-cysteine (HY-111592). S-(5′-Adenosyl)-L-cysteine is a cysteine derivative .
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- HY-W748312
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1, 2, 3, 4, 7, 8, 9-Heptachloro-dibenzofuran- 13C12 is 13C labeled 1,2,3,4,7,8,9-Heptachlorodibenzo[b,d]furan .
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- HY-166922S
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2,3,4,5-Tetrachloro-4′-methoxy biphenyl- 13C12 is 13C labeled 2,3,4,5-Tetrachloro-4′-methoxy biphenyl .
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- HY-166953S
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1,2,3,4,6,8-Hexachloro-dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,3,4,6,8-Hexachloro-dibenzo-p-dioxin .
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- HY-W751505
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2-(Methoxymethoxy)-1,3-dimethylbenzene- 13C8,d3 is the deuterium and 13C labeled 2-(Methoxymethoxy)-1,3-dimethylbenzene.
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- HY-134423S
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Stearoyl coenzyme A- 13C18 (lithium) is the 13C labeled Stearoyl coenzyme A lithium . Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes .
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- HY-N0230S5
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β-Alanine- 13C (2-Carboxyethylamine- 13C) is 13C labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
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- HY-166952S
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2′,3,4′,5,5′-Pentachloro-4-biphenylol- 13C12 is 13C labeled 2′,3,4′,5,5′-Pentachloro-4-biphenylol .
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- HY-B0183S
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Ellagic acid- 13C12 is 13 C-labeled Ellagic acid (HY-B0183). Ellagic acid is a natural antioxidant and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC50 of 40 nM and a Ki of 20 nM .
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- HY-B2227BS3
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Lactate- 13C-1 sodium (20% in water) is the 13C labeled Lactate (sodium) . Lactate (Lactic acid) sodium (20% in water) is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium (20% in water) functions in a variety of biochemical processes .
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- HY-W715187S
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3-Bromo-2,7,8-trichloro dibenzofuran- 13C12 is 13C labeled 3-Bromo-2,7,8-trichlorodibenzo[b,d]furan .
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- HY-W715121S
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2,3,7,8-Tetrabromo dibenzo-p-dioxin- 13C12 is 13C labeled 2,3,7,8-Tetrabromodibenzo[b,E][1,4]dioxine .
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- HY-100582S
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Ribitol-1- 13C is the 13C labeled Ribitol. Ribitol is a crystalline pentose alcohol formed by the reduction of ribose. Enhancing the flux of D-glucose to the pentose phosphate pathway in Saccharomyces cerevisiae for the production of D-ribose and ribitol .
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- HY-Y0366S
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Lauric acid- 13C is the 13C labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.
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- HY-W100312S
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o-Toluidine-13C6 hydrochloride (Toluene, 2-amino-13C6 hydrochloride) is the 13C labeled isotope of o-Toluidine hydrochloride (HY-W100312) .
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- HY-W778183
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3,5,6-Trichloro-2-pyridinol- 13C5 (TCPy- 13C5) is 13C labeled 3,5,6-Trichloro-2-pyridinol .
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- HY-17016S3
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Oseltamivir- 13C,d3 (phosphate) (GS 4104- 13C,d3 (phosphate)) is 13C labeled Oseltamivir (phosphate). Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
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- HY-B0389S19
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D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sign
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- HY-B0158S2
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Cytidine- 13C-1 is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami
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- HY-N1480S3
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(-)-Fucose- 13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
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- HY-W715198S
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4-Bromo-2,3,7,8-tetrachlorodibenzofuran- 13C12 is 13C labeled 4-Bromo-2,3,7,8-tetrachlorodibenzo[b,d]furan .
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- HY-111095S2
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D-(-)-Lactic acid- 13C-1 is the 13C labeled D-(-)-Lactic acid. D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants .
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- HY-N1480S2
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(-)-Fucose- 13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
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- HY-166956S
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Chlordene- 13C10 is 13C labeled 1,7,8,9,10,10-Hexachlorotricyclo[5.2.1.0,2,6]deca-3,8-diene .
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- HY-B1374S2
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Florfenicol- 13C6 (SCH-25298- 13C6) is 13C labeled Florfenicol. Florfenicol ((-)-Florfenicol) is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions .
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- HY-156326S
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(3E,5E)-Octadien-2-one- 13C2 is 13C labeled (3E,5E)-Octadien-2-one.
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- HY-150708S
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Ethyl 2-hydroxy-2-methyl-3-oxobutanoate- 13C is the 13C labeled Ethyl 2-hydroxy-2-methyl-3-oxobutanoate .
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- HY-113248S1
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3-Nitro-L-tyrosine- 13C6 is the 13C labeled 3-Nitro-L-tyrosine . 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions .
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- HY-W010452S1
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3-Hydroxybutyric acid- 13C4 (sodium) is the 13C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids .
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- HY-W010452S2
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3-Hydroxybutyric acid- 13C2 (sodium) is the 13C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids .
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- HY-138622S
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24:0 Lyso PC- 13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .
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- HY-156326S1
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(3E,5Z)-Octadien-2-one- 13C2 is 13C labeled (3E,5Z)-Octadien-2-one.
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- HY-B0389S25
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D-Glucose- 13C,d is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
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- HY-W721295S
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N-(1-Deoxy-D-fructos-1-yl)-L-methionine- 13C6 is 13C labeled N-(1-Deoxy-D-fructos-1-yl)-L-methionine.
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- HY-W013061S11
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Tripalmitin (Glycerol 13C3, 13C 99%) is 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite .
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- HY-N1480S1
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(-)-Fucose- 13C-1 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
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- HY-Y1093S3
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Ethyl acetoacetate- 13C is the 13C labeled Ethyl acetoacetate . Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds . Ethyl acetoacetate is an inhibitor of bacterial biofilm .
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- HY-W010450S3
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Thymine- 13C is the 13C labeled Thymine . Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM .
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- HY-42680S
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D-Tagatose- 13C is the 13C labeled D-Tagatose. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice
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- HY-W793608S
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N-(1-Deoxy-D-fructos-1-yl)-L-asparagine- 13C6 is 13C labeled N-(1-Deoxy-D-fructos-1-yl)-L-asparagine.
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- HY-W765261
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Eprinomectin B1a- 13C,d3 is the deuterium and 13C labeled Eprinomectin B1a (HY-N8483). Eprinomectin B1a is a Eprinomectin (HY-12643) metabolite (an antiparasitic compound) .
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- HY-W748346
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2,2′,3,3′,5,5′,6-Heptachloro biphenyl- 13C12 is 13C labeled 2,2',3,3',5,5',6-Heptachloro-1,1'-biphenyl .
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- HY-W715365S
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1,2,3-Tribromo-5-(3,4-dibromophenoxy)benzene- 13C12 is 13C labeled 1,2,3-Tribromo-5-(3,4-dibromophenoxy)benzene .
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- HY-128850S1
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N-Acetyl-D-mannosamine- 13C is the 13C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)
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- HY-W128657S
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3-Chloro-2-hydroxypropanoic acid- 13C3 (2-Hydroxy-3-chloropropionic Acid- 13C3) is 13C labeled 3-Chloro-2-hydroxypropanoic acid .
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- HY-166931S
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2,2',4,4'-Tetrabromo-6-methoxy-diphenyl ether- 13C12 is 13C labeled 2,2',4,4'-Tetrabromo-6-methoxy-diphenyl ether .
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- HY-W747168
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Ethyl Vinyllactate- 13C2,d3 is the deuterium and 13C labeled Ethyl 2-hydroxy-2-methylbut-3-enoate (HY-W713350).
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- HY-139145S
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Etbicyphat- 13C3 is the 13C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors .
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- HY-166958S
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1,2,3,4,6,7,9-Heptachloro dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,3,4,6,7,9-Heptachloro dibenzo-p-dioxin .
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- HY-B0377S1
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Famotidine- 13C (MK-208- 13C) is 13C labeled Famotidine. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
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- HY-109591S
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Oleoyl coenzyme A- 13C18 (lithium) is the 13C labeled Oleoyl Coenzyme A lithium . Oleoyl coenzyme A (Oleoyl-CoA) is a thioester of oleic acid and coenzyme A. Oleoyl coenzyme A has a role as an Escherichia coli metabolite and a mouse metabolite .
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- HY-W017086S2
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Dibenzo[b,d]furan- 13C12 is 13C labeled Dibenzo[b,d]furan. Dibenzo[b,d]furan is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-W714574S
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2,2′,3,3′,4,4′,5-Heptachloro biphenyl- 13C12 is 13C labeled 2,2',3,3',4,4',5-Heptachloro-1,1'-biphenyl .
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- HY-166925S
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2′,3,3′,4′,5,5′-Hexachloro-4-biphenylol- 13C12 is 13C labeled 2′,3,3′,4′,5,5′-Hexachloro-4-biphenylol .
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- HY-Y1055S
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Guanine- 13C is the 13C labeled Guanine . Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-Y1093S1
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Ethyl acetoacetate- 13C4 is the 13C labeled Ethyl acetoacetate . Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds . Ethyl acetoacetate is an inhibitor of bacterial biofilm .
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- HY-166901S
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2,3′,4,5,5′-Pentachloro-4′-methoxy biphenyl- 13C12 is 13C labeled 2,3′,4,5,5′-Pentachloro-4′-methoxy biphenyl .
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- HY-W777334
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2,5-Dioxopyrrolidin-1-yl nicotinate- 13C6,d4 is the deuterium and 13C labeled 2,5-Dioxopyrrolidin-1-yl nicotinate.
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- HY-W242887S2
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D-Gulose- 13C is the 13C labeled (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal .
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- HY-W337886S
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2-Ethylhexyl 2,3,4,5-tetrabromobenzoate- 13C6,d17 is 13C labeled 2-Ethylhexyl 2,3,4,5-tetrabromobenzoate .
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- HY-W738582S
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N-(1-Deoxy-D-fructos-1-yl) -L-threonine- 13C6 is 13C labeled N-(1-Deoxy-D-fructos-1-yl)-L-methionine.
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- HY-Y0264S2
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4-Hydroxybenzoic acid- 13C is the 13C labeled 4-Hydroxybenzoic acid . 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL .
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- HY-W018587S
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Bis(2-Ethylhexyl)-tetrabromo phthalate- 13C6,d34 is 13C labeled Bis(2-ethylhexyl) 3,4,5,6-tetrabromophthalate .
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- HY-W013061S10
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Propane-1,2,3-triyl tripalmitate- 13C is the 13C labeled Propane-1,2,3-triyl tripalmitate . Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
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- HY-B0389S21
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D-Glucose- 13C,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sig
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- HY-112537S1
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D-Glucose 6-Phosphate- 13C6 disodium xhydrate is the 13C labeled D-Glucose 6-phosphate (HY-112537) . D-Glucose 6-phosphate is a glucose sugar phosphorylated at the hydroxy group on carbon 6 .
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- HY-B0211S1
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Riluzole- 13C6 (PK 26124- 13C6) is 13C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
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- HY-B1459AS
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Dicloxacillin- 13C4 is the 13C labeled Dicloxacillin . Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus .
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- HY-150663S
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1α,25-Dihydroxyvitamin D3-(23,24,25,26,27- 13C5) solution is the 13C labeled 1α,25-Dihydroxyvitamin D3 .
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- HY-N1150S2
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Thymidine- 13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication
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- HY-W653853
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Ritonavir- 13C3 is 13C labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.61 μM .
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- HY-W587423S
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2,2′,3,3′,4,4′,5,5′,6-Nonabromo diphenyl ether- 13C12 is 13C labeled 2,2′,3,3′,4,4′,5,5′,6-Nonabromodiphenyl ether .
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- HY-Y0520S
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Itaconic acid- 13C5 is the 13C labeled Itaconic acid. Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors .
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- HY-14781S2
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Levomefolic acid- 13C5 is the 13C labeled Levomefolic acid . Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .
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- HY-W749374
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1,2-Bis(2,4,6-tribromophenoxy)ethane- 13C12 is 13C labeled 1,1-(1,2-Ethanediylbis(oxy))bis(2,4,6-tribromobenzene) .
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- HY-W013061S5
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Propane-1,2,3-triyl tripalmitate- 13C2 is the 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
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- HY-W013061S1
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Propane-1,2,3-triyl tripalmitate- 13C3 is the 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
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- HY-W748332
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PCB118- 13C12 (CDE-99- 13C12; PCB No 118- 13C12; 2,3',4,4',5-Pentachlorobiphenyl- 13C12) is 13C labeled PCB118 .
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- HY-B0389S20
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D-Glucose- 13C,d-1 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
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- HY-W012864S
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(2S,3R)-2,3,4-Trihydroxybutanal- 13C is the 13C labeled (2S,3R)-2,3,4-Trihydroxybutanal .
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- HY-22306S
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β-D-Glucose pentaacetate- 13C6 is the 13C labeled β-D-Glucose pentaacetate[1]. β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is used in biochemical reaction.
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- HY-N0379S18
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D-mannose- 13C6,d7 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-N6692S
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Diacetoxyscirpenol- 13C19 is 13C labeled Diacetoxyscirpenol (HY-N6692). Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin, a secondary metabolite product of fungi. Diacetoxyscirpenol (DAS) consumption induces haematological disorders (neutropenia, aplastic anemia) in human and animals .
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- HY-166914S
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2,2',3,3',4,5,5'-Heptachloro-4'-methoxybiphenyl- 13C12 is 13C labeled 2,2',3,3',4,5,5'-Heptachloro-4'-methoxybiphenyl .
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- HY-104026CS
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L-Kynurenine- 13C10 (sulfate hemihydrate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .
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- HY-15409S1
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Empagliflozin- 13C6 (BI 10773- 13C6) is 13C labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2 .
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- HY-143679S
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4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate-13C6 is the 13C labeled isotope of 4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate .
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- HY-W768338
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Sucrose- 13C is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
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- HY-A0161S
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Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
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- HY-166896S
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2,3,3',4',5,5'-Hexachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,3,3',4',5,5'-Hexachloro-1,1'-biphenyl .
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- HY-W748345
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2,3',4,4',5,5'-Hexachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,3',4,4',5,5'-Hexachloro-1,1'-biphenyl .
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- HY-B1328S3
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Pyridoxine- 13C4 (Pyridoxol- 13C4) is 13C labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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- HY-W008351S
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L-Ribose- 13C is the 13C labeled L-Ribose. L-Ribose, a non-naturally occurring pentose, is an ideal starting material for use in synthesizing L-nucleosides analogues. Many anticancer and antiviral agents are synthesized based on a backbone of L-Ribose and i
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- HY-42680S1
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D-Tagatose- 13C-1 is the 13C labeled D-Tagatose. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit jui
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- HY-W018772S1
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D-Ribose- 13C is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glycati
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- HY-W242887S3
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D-Gulose-1- 13C is the 13C labeled (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal .
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- HY-Y0479AS
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L-Lactic acid- 13C3 ((S)-2-hydroxypropanoic- 13C3) sodium (20% in water) is the 13C labeled L-Lactic acid. L-Lactic acid- 13C3 sodium (20% in water) can be used for lactate metabolism research .
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- HY-166945S
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2,3,3′,4,5,5′-Hexachloro-4′-methoxy biphenyl- 13C12 is 13C labeled 2,3,3′,4,5,5′-Hexachloro-4′-methoxy biphenyl .
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- HY-W708160S
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1,2,3-Tribromo-4-(2,4,5-tribromophenoxy)benzene- 13C12 is 13C labeled 1,2,3-Tribromo-4-(2,4,5-tribromophenoxy)benzene .
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- HY-W517076S
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1,2,3,6,7,8-Hexachloro dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,3,6,7,8-Hexachlorodibenzo[b,e][1,4]dioxine .
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- HY-W750238
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Scoparone- 13C2,d6 is the deuterium and 13C labeled Scoparone (HY-N0228). Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .
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- HY-141857S
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5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-2,4,5- 13C3 is the deuterium and 13C labeled 5-(4-Hydroxyphenyl)-5-phenyl-hydantoin .
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- HY-N1482S
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Methyl palmitate- 13C16 is the 13C labeled Methyl palmitate. Methyl palmitate, an acaricidal compound occurring in green walnut husks, inhibits phagocytic activity and immune response. Methyl palmitate also posseses anti-inflammatory and antifibrotic effects .
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- HY-N1150S5
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Thymidine-2′- 13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication .
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- HY-17436S3
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(R)-Clevidipine- 13C,d3 is the deuterium and 13C labeled Clevidipine . Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension .
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- HY-10158S1
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Bosutinib- 13C,d3 (SKI-606- 13C,d3) is 13C labeled Bosutinib. Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively .
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- HY-40354S2
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Tofacitinib- 13C,d3 (Tasocitinib- 13C,d3) is 13C labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
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- HY-B1278AS
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DL-α-Tocopherol acetate- 13C4,d6 is the deuterium and 13C labeled DL-α-Tocopherol acetate . DL-α-Tocopherol acetate is a vitamin E derivative which is often included in the formulations of enteral nutrition .
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- HY-N0470S8
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L-Lysine- 13C6 hydrochloride is the 13C labeled L-Lysine hydrochloride . L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health .
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- HY-13613S
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Dutasteride- 13C6 is the 13C labeled Dutasteride . Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
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- HY-B0221S
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Amphotericin B- 13C6 is 13C labeled Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
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- HY-21268S
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Methyl linolenate- 13C18 is the 13C labeled Methyl linolenate[1]. Methyl linolenate is a polyunsaturated fattly acid (PUFA). It is used in studies on the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids[2][3]. The IC50 is 60 uM[4].
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- HY-10984S4
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Pomalidomide- 13C5 (CC-4047- 13C5) is 13C labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
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- HY-N0420S2
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Succinic acid- 13C4 is the 13C labeled Succinic acid . Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries .
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- HY-19657S
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Oxypurinol- 13C, 15N2 is 15N and 13C labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .
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- HY-10268S2
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Betrixaban- 13C6 (PRT054021- 13C6) is 13C labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect .
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- HY-A0132S1
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N-Acetyl-D-glucosamine- 13C is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc .
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- HY-128850S2
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N-Acetyl-D-mannosamine- 13C-1 is the 13C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)
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- HY-N6685S1
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3-Acetyldeoxynivalenol- 13C17 is the 13C labeled 3-Acetyldeoxynivalenol (HY-N6685) . 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative , is a blood-brain barrier (BBB) permeable mycotoxin .
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- HY-128793S
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trans-Stilbene- 13C2 ((E)-Stilbene- 13C2) is the 13C labeled trans-Stilbene (HY-128793) . trans-Stilbene ((E)-Stilbene) is used in the manufacturing of dye lasers, optical brighteners, non-steroidal synthetic estrogens .
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- HY-W015913S3
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Sodium 2-oxopropanoate- 13C is the 13C labeled Sodium 2-oxopropanoate . Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .
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- HY-B0389S22
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D-Glucose- 13C2,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
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- HY-D0186S
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2'-Deoxyuridine-1′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
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- HY-B0612AS
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Lercanidipine- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Lercanidipine hydrochloride . Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect .
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- HY-W041171S
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3-Chloro-L-tyrosine- 13C6 is the 13C labeled 3-Chloro-L-tyrosine . 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima .
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- HY-166929S
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2,2′,3,4′,5,5′,6-Heptachloro-4-methoxy biphenyl- 13C12 is 13C labeled 2,2′,3,4′,5,5′,6-Heptachloro-4-methoxy biphenyl .
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- HY-D0186S3
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2'-Deoxyuridine-5′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
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- HY-D0186S2
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2'-Deoxyuridine-3′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
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- HY-N1150S4
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Thymidine- 13C-2 is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication
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- HY-B1779S5
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Sucrose- 13C6 is the 13C labeled Sucrose . Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al .
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- HY-W013061S4
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Propane-1,2,3-triyl tripalmitate- 13C3-1 is the 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
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- HY-W748321
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2,2',3,4',5,6,6'-heptachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,4',5,6,6'-Heptachloro-1,1'-biphenyl .
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- HY-13966S2
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2-Deoxy-D-glucose- 13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .
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- HY-W716411S
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1,2,3,4,5-Pentabromo-6-(2,3-dibromophenoxy)benzene- 13C12 is 13C labeled 1,2,3,4,5-Pentabromo-6-(2,3-dibromophenoxy)benzene .
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- HY-D0186S1
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2'-Deoxyuridine-2′- 13C is the 13C labeled 2'-Deoxyuridine. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxud[1]
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- HY-W748284
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2,4,4'-Trichloro-1,1'-biphenyl- 13C12 (2,4,4'-Trichlorobiphenyl- 13C12) is 13C labeled 2,4,4'-Trichloro-1,1'-biphenyl .
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- HY-W006057AS17
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3-Methyl-2-oxobutanoic acid- 13C2 is the 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
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- HY-N0229S19
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L-Alanine-1,2- 13C2 (Alanine- 13C2) is 13C labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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- HY-165124S
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1,2,3,4,6,7,8-Heptachlorodibenz- 13C12 is 13C labeled 1,2,3,4,6,7,8-Heptachlorodibenz. 1,2,3,4,6,7,8-Heptachlorodibenz is a biochemical reagent.
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- HY-B1337S5
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Choline- 13C2 (chloride) is the 13C labeled Choline chloride . Choline chloride is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders .
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- HY-W006057AS16
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Sodium 3-methyl-2-oxobutanoate- 13C5 is the 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
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- HY-W715180S
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2,3-Dibromo-7,8-dichloro dibenzo-p-dioxin- 13C12 is 13C labeled 2,3-Dibromo-7,8-dichlorodibenzo[b,E][1,4]dioxine .
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- HY-N1150S3
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Thymidine- 13C-1 is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication
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- HY-W012864S1
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(2S,3R)-2,3,4-Trihydroxybutanal- 13C-1 is the 13C labeled (2S,3R)-2,3,4-Trihydroxybutanal .
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- HY-W012864S2
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(2S,3R)-2,3,4-Trihydroxybutanal- 13C-2 is the 13C labeled (2S,3R)-2,3,4-Trihydroxybutanal .
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- HY-10984S3
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Pomalidomide- 15N, 13C5 is 15N and 13C labeled Pomalidomide (HY-10984). Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
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- HY-A0132S3
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N-Acetyl-D-glucosamine-2- 13C is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc .
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- HY-W018772S4
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D-Ribose- 13C-3 is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca
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- HY-B0400S2
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D-Sorbitol- 13C-1 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
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- HY-W753141
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p,p'-DDE- 13C12 is 13C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM .
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- HY-112251S
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D-Lin-MC3-DMA- 13C3 is the 13C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle .
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- HY-W015307S
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4-Ethyloctanoic acid- 13C2 is 13C labeled 4-Ethyloctanoic acid (HY-W015307). 4-Ethyloctanoic acid is a natural compound first isolated from Saussurea lappa Clarke, widely used as a safe flavoring compound and acts as food additive .
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- HY-17530S
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Aldicarb sulfone- 13C2,d3 is the deuterium and 13C labeled Aldicarb sulfone (HY-17530). Aldicarb sulfone is one of the metabolites of the carbamate pesticide Aldicarb and has insecticidal activity. Aldicarb sulfone is also an inhibitor of cholinesterase .
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- HY-W018772S2
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D-Ribose- 13C-1 is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca
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- HY-B0554S1
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Norethindrone- 13C2 (Norethisterone- 13C2) is the 13C labeled Norethindrone (HY-B0554) . Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea .
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- HY-N6683S1
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15-Acetyl-deoxynivalenol- 13C17 is the 13C labeled 15-Acetyl-deoxynivalenol (HY-N6683) . 15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .
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- HY-104026BS
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L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .
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- HY-W015913S4
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2-Oxopropanoate- 13C5 (sodium) is the 13C labeled Sodium 2-oxopropanoate . Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .
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- HY-166908S
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2,2',3,3',4,4',5,6,6'-Nonabromo diphenyl ether- 13C12 is 13C labeled 1,2,3,4,5-Pentabromo-6-(2,3,4,6-tetrabromophenoxy)benzene .
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- HY-B0400S3
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D-Sorbitol- 13C-2 is the 13C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary
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- HY-W018772S5
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D-Ribose- 13C-4 is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca
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- HY-W018772S3
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D-Ribose- 13C-2 is the 13C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca
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- HY-N0097S4
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Guanosine- 13C10 is the 13C labeled Guanosine (HY-N0097). Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .
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- HY-B1449S10
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1 Publications Verification
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Uridine- 13C5 (β-Uridine- 13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.
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- HY-W748282
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2,3,3',4,4',5,5',6-Octachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,3,3',4,4',5,5',6-Octachloro-1,1'-biphenyl .
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- HY-W748349
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2,2',3,3',4,4',5,5'-Octachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,3',4,4',5,5'-Octachloro-1,1'-biphenyl .
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- HY-W768340
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Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
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- HY-W778225
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Vanillic acid- 13C6 is the 13C labeled isotope of Vanillic acid- 13C6(HY-N0708 ).Vanillic acid is a flavoring agent found in edible plants and fruits, and in the root of angelica. Vanillic acid inhibits NF-κB activation. It has anti-inflammatory and antimicrobial activities.
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- HY-N0420S4
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Succinic acid- 13C2 is the 13C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].
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- HY-Y0836S
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Diethyl succinate- 13C4 is the 13C labeled Diethyl succinate . Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring .
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- HY-W779534
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4,5-Dimethyl-3-hydroxy-2(5H)-furanone- 13C2 is 13C labeled 4,5-Dimethyl-3-hydroxy-2(5H)-furanone- 13C2.
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- HY-W751832
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5,6-Diaminopyrimidine-2,4-diol hydrochloride- 13C3 (5,6-Diaminouracil hydrochloride- 13C3) is the 13C-labeled5,6-Diaminopyrimidine-2,4-diol (HY-W002107).
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- HY-A0132S2
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N-Acetyl-D-glucosamine- 13C-1 is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc .
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- HY-N0420S3
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Butanedioic acid- 13C2 is the 13C labeled Succinic acid[1]. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[2][3].
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- HY-15029S2
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(±)-Naproxen- 13C,d3 is the deuterium and 13C labeled (±)-Naproxen . (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively.
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- HY-W748204
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1,2,3,7,8-Pentachloro dibenzo-p-dioxin- 13C12 is 13C labeled 1,2,3,7,8-Pentachlorodibenzo-p-dioxin. 1,2,3,7,8-Pentachlorodibenzo-p-dioxin is a biochemical reagent .
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- HY-B0400S16
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D-Sorbitol- 13C6 is the 13C labeled D-Sorbitol . D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement .
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- HY-W748355
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2,2',3,3',5,5',6,6'-Octachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,3',5,5',6,6'-Octachloro-1,1'-biphenyl .
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- HY-A0132S5
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N-Acetyl-D-glucosamine- 13C-3 is the 13C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc .
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- HY-W654136
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2'-Deoxycytidine-2'- 13C is 13C labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, can inhibit biological effects of Bromodeoxyuridine (Brdu). 2'-Deoxycytidine is essential for the synthesis of nucleic acids, that can be used for the research of cancer .
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- HY-14608S10
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L-Glutamic acid- 13C2 is the 13C labeled L-Glutamic acid . L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals .
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- HY-W777456
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Phenanthrene- 13C6 is the 13C labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
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- HY-B0228S5
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Adenosine- 13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology,
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- HY-B0166S2
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L-Ascorbic acid- 13C-1 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen
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- HY-18341S2
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L-Thyroxine- 13C6 is the 13C labeled L-Thyroxine . L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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- HY-W007928S1
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1-O-Acetyl 2,3,5-tri-O-benzoyl-beta-D-ribofuranoside- 13C-1 is the 13C labeled 1-O-Acetyl-2,3,5-Tri-O-benzoyl-beta-D-Ribofuranose .
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- HY-B0476S1
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Phenacetin- 13C is the 13C labeled Phenacetin . Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats .
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- HY-15027S2
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5-Aminosalicylic acid- 13C6 is the 13C labeled 5-Aminosalicylic Acid . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
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- HY-B0166S5
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L-Ascorbic acid- 13C-4 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collag
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- HY-13966S4
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2-Deoxy-D-glucose- 13C-1 is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .
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- HY-B0389S10
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D-Glucose- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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- HY-N0305S3
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5-Aminolevulinic acid- 13C-1 (5-ALA- 13C-1) hydrochloride is the 13C labeled 5-Aminolevulinic acid hydrochloride . 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles .
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- HY-B1654S
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Flavin adenine dinucleotide- 13C5 (FAD- 13C5) ammonium is 13C labeled Flavin adenine dinucleotide (HY-B1654). Flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
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- HY-B0271S1
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Pyrazinamide- 13C, 15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
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- HY-W777702
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2,2',3,4',5,5',6-Heptachloro-4-biphenylol- 13C12 is 13C labeled 2,2',3,4',5,5',6-Heptachloro-[1,1'-biphenyl]-4-ol .
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- HY-N0610AS2
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Cinnamic acid- 13C3 (3-Phenylacrylic acid- 13C3) is the 13C labeled Cinnamic acid (HY-N0610A). Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells .
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- HY-W016433S
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2-Aminofluorene- 13C is the 13C labeled 2-Aminofluorene . 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .
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- HY-B0166S4
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L-Ascorbic acid- 13C-3 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen
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- HY-B0190S1
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Nafamostat formate salt- 13C6 is the 13C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .
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- HY-I0301S
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D-(+)-Glucono-1,5-lactone-1- 13C is the 13C labeled D-(+)-Glucono-1,5-lactone. D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activ .
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- HY-B0166S3
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L-Ascorbic acid- 13C-2 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen
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- HY-W715311S
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2,2',3,3',4',5,5'-Heptachloro-4-biphenylol- 13C12 is 13C labeled 2,2',3,3',4',5,5'-Heptachloro-[1,1'-biphenyl]-4-ol .
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- HY-18342S1
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Diflunisal- 13C6 (MK-647- 13C6) is 13C labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
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- HY-W012998S1
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2,3-Pentanedione- 13C2 is 13C labeled Furaneol (HY-N7093). Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines .
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- HY-B0228S3
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Adenosine-3′- 13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo
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- HY-A0090S
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Nitrofurantoin- 13C3 is the 13C labeled Nitrofurantoin (HY-A0090) . Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections .
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- HY-126373S1
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SN-38 glucuronide- 13C6 is the 13C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
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- HY-150012S1
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N-Lactoyl-Phenylalanine- 13C6 (Lac-Phe- 13C6) is 13C labeled N-Lactoyl-Phenylalanine. N-Lactoyl-Phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-Phenylalanine can reduce obesity and improve glucose tolerance .
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- HY-W748320
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2,2',3,3',4,5,5',6,6'-Nonachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,3',4,5,5',6,6'-Nonachloro-1,1'-biphenyl .
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- HY-Y0264S
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4-Hydroxybenzoic acid- 13C6 is the 13C labeled isotope of 4-Hydroxybenzoic acid- 13C6.4-Hydroxybenzoic acid is a phenolic derivative of benzoic acid, which can inhibit most Gram-positive bacteria and some Gram-negative bacteria with an IC50 value of 160 μg/mL.
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- HY-B0947S1
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Sulfanitran- 13C6 is the 13C labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG).
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- HY-166939S
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3,4,5,6-Tetrabromo[1,1′-biphenyl]-2,2′-diol- 13C12 is 13C labeled 3,4,5,6-Tetrabromo[1,1′-biphenyl]-2,2′-diol .
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- HY-B0228S2
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Adenosine-2′- 13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo
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- HY-17410S2
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Iloperidone- 13C,d3 (HP 873- 13C,d3) is 13C labeled Iloperidone. Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .
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- HY-W748350
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2,2',3,3',4,4',5,5',6-Nonachloro-1,1'-biphenyl- 13C12 is 13C labeled 2,2',3,3',4,4',5,5',6-Nonachloro-1,1'-biphenyl .
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- HY-W011297S3
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Methyl arachidonate- 13C5 (Arachidonic acid methyl ester- 13C5) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
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- HY-W006057AS14
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Sodium 3-methyl-2-oxobutanoate- 13C,d4 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
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- HY-W762019S
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1,2,3,4,7,8-Hexachloro dibenzo-p-dioxin- 13C12 (1,2,3,4,7,8-HxCDD- 13C12) is 13C labeled 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin .
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- HY-10163S2
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Dabigatran- 13C6 is the 13C labeled Dabigatran . Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM) .
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- HY-B0228S4
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Adenosine-1′- 13C is the 13C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo
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- HY-N0092S1
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Inosine- 13C is the 13C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors .
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- HY-W015851S
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3-Hydroxybutanoic acid-13C- 13C (sodium) is the 13C labeled 3-Hydroxybutanoic acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .
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- HY-B0389S11
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D-Glucose- 13C-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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- HY-W008807S
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Phosphoenolpyruvic acid (potassium)- 13C2 is the 13C labeled Phosphoenolpyruvic acid potassium (HY-W008807) . Phosphoenolpyruvic acid (Phosphoenolpyruvate) potassium is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid potassium is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid potassium also exhibits cytoprotective and anti-oxidative properties .
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- HY-W751082
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H-N-Me-Ala-OH- 13C,d3 (N-Methyl-L-alanine- 13C,d3) is the deuterium and 13C labeled H-N-Me-Ala-OH (HY-W015926). H-N-Me-Ala-OH is an alanine derivative .
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- HY-B0389S17
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D-Glucose- 13C-5 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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- HY-B0389S16
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D-Glucose- 13C-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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- HY-B0389S13
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D-Glucose- 13C-3 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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- HY-W748291
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2,3,4,4',5-Pentachloro-1,1'-biphenyl- 13C12 (2,3,4,4',5-Pentachlorobiphenyl- 13C12) is 13C labeled 2,3,4,4',5-Pentachloro-1,1'-biphenyl .
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- HY-W777166
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Aprepitant- 13C2,d2 (Major) (MK-0869- 13C2,d2) is 13C labeled Aprepitant. Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a Kd of 86 pM.
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- HY-B0389S14
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D-Glucose- 13C2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-N6723S
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Fumonisin B2- 13C34 is the 13C labeled Fumonisin B2 (HY-N6723) . Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .
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- HY-Y1636S1
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Fmoc-Arg(Pbf)-OH- 13C6 is the 13C labeled Fmoc-Arg(Pbf)-OH . Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
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- HY-79369S1
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Succinic anhydride- 13C2 is the 13C labeled Succinic anhydride . Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide .
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- HY-W006057AS15
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Sodium 3-methyl-2-oxobutanoate- 13C,d4-1 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
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- HY-W779542
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(2E,4E,6E)-2,4,6-Nonatrienal- 13C2 is 13C labeled (2E,4E,6E)-2,4,6-Nonatrienal.
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- HY-N0304S2
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1 Publications Verification
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L-DOPA- 13C is the 13C labeled L-DOPA . L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
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- HY-100807S1
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Quinolinic acid- 13C7 is the 13C labeled Quinolinic acid (HY-100807) . Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction .
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- HY-14283S
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Luliconazole- 13C7 (NND 502- 13C7) is 13C labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .
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- HY-W585819S
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3-Chloropropane-1,2-diol dipalmitate- 13C3 is 13C labeled 3-Chloropropane-1,2-diol dipalmitate. 3-Chloropropane-1,2-diol dipalmitate is a free fatty acid consisting mainly of diesters .
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- HY-W269693S
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5-(4-Hydroxyphenyl)-5-phenylimidazolidine-2,4-dione- 13C3,d5 is the deuterium and 13C labeled 5-(4-Hydroxyphenyl)-5-phenylimidazolidine-2,4-dione .
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- HY-W777978
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2-Bromo-3'-methoxyacetophenone- 13C,d3 (α-Bromo-3'-methoxyacetophenone- 13C,d3) is the deuterium and 13C labeled 2-Bromo-3'-methoxyacetophenone (HY-W004800).
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- HY-W243018S
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1,2:5,6-Di-O-isopropylidene-a-D-glucofuranose-1,2,3,4,5,6- 13C6 is the 13C labeled 1,2:5,6-Di-O-isopropylidene-a-D-glucofuranose-1,2,3,4,5,6 .
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- HY-17430S2
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Amprenavir- 13C6 (VX-478- 13C6) is 13C labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.09 μM.
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- HY-W011297S2
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Methyl arachidonate- 13C4 (Arachidonic acid methyl ester- 13C4) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
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- HY-W009362S
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DL-Isocitric acid- 13C4 (trisodium salt) is a 13C labeled DL-Isocitric acid (trisodium salt) (HY-W009362). DL-Isocitric acid trisodium salt is an endogenous metabolite. DL-Isocitric acid trisodium salt is a substrate in the citric acid cycle. DL-Isocitric acid trisodium salt can be used as a marker for determining the composition of isocitrates in fruit products, including fruit juices.
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- HY-B0411S2
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Domperidone- 13C6 (R33812- 13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine .
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- HY-10392S
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Sutezolid- 13C4 (PNU-100480- 13C4) is 13C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
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- HY-101277S1
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Vadadustat- 13C6 (PG-1016548- 13C6) is 13C labeled Vadadustat. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .
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- HY-B0389S15
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D-Glucose- 13C2-4 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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- HY-150918S
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3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl- 13C5 is the 13C labeled 3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl .
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- HY-N0001S2
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(-)-Epicatechin- 13C3 ((-)-Epicatechol- 13C3) is 13C labeled (-)-Epicatechin. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
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- HY-76082S1
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L-Pyroglutamic acid- 13C5 is the 13C labeled L-Pyroglutamic acid (HY-76082) . L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid can be used as a biomarker for systemic lupus erythematosus (SLE) .
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- HY-B0149S2
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Tranexamic acid- 13C6 (Cyclocapron- 13C6) is 13C labeled Tranexamic acid. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .
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- HY-W006057AS13
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Sodium 3-methyl-2-oxobutanoate- 13C4,d3 is the deuterium and 13C labeled Sodium 3-methyl-2-oxobutanoate . Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli .
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- HY-N0001S
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(±)-Epicatechin- 13C3 is the 13C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB .
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- HY-12008S1
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Erlotinib- 13C6 hydrochloride is the 13C labeled Erlotinib Hydrochloride . Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM . Erlotinib- 13C6 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-13966S3
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2-Deoxy-D-glucose- 13C6 (2-DG- 13C6) is 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .
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- HY-W778290
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5-Chloro-2-methoxy-benzoic Acid- 13C,d3 (5-Chloro-o-anisic acid (COOH=1)- 13C,d3) is the deuterium and 13C labeled 5-Chloro-2-methoxybenzoic acid (HY-W016163).
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- HY-B0389S18
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D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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- HY-109590S3
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Arachidonic acid- 13C4 (Immunocytophyt- 13C4) is 13C labeled Arachidonic acid. Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function .
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- HY-109120S1
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Odevixibat- 13C6 is 13C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
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- HY-W106014S
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[1,1'-Biphenyl]-3-amine-13C6 hydrochloride (Biphenyl-3-amine-13C6 hydrochloride) is the 13C labeled isotope of [1,1'-Biphenyl]-3-amine hydrochloride (HY-W106014) .
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- HY-113365S2
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Cholestenone- 13C2 is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells .
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- HY-129974S
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3,3'-Diiodo-L-thyronine- 13C6 is the 13C labeled 3,3'-Diiodo-L-thyronine . 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity .
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- HY-13017S4
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Ivacaftor- 13C6 (VX-770- 13C6) is 13C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
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- HY-18569S4
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3-Indoleacetic acid- 13C6 is the 13C labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
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- HY-19528S2
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SAH- 13C10 is the 13C labeled SAH . SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM .
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- HY-B0389S12
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D-Glucose- 13C-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-B0389S9
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D-Glucose- 13C3-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .
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- HY-113365S1
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Cholestenone- 13C is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells .
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- HY-W750297
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p,p'-DDD- 13C12 is 13C labeled p,p'-DDD. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT .
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- HY-B0214S3
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Prednisone- 13C2,d2 (Dehydrocortisone- 13C2,d2) is 13C labeled Prednisone. Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus .
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- HY-15772S1
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Osimertinib- 13C,d3 is the deuterium and 13C labeled Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively.
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- HY-15388S2
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Tazarotene- 13C6 (AGN 190168- 13C6) is 13C labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-17007S2
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Saquinavir- 13C6 (Ro 31-8959- 13C6) is 13C labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells .
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- HY-B0495S7
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Lamotrigine- 13C (LTG- 13C) is 13C labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .
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- HY-12009S
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Pazopanib- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Pazopanib hydrochloride . Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively .
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- HY-B0511S3
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Biotin- 13C5 (Vitamin B7- 13C5) is 13C labeled Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
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- HY-103447S2
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Zearalenone- 13C7 (Mycotoxin F2- 13C7) is 13C labeled Zearalenone. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
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- HY-W748354
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2,2',4,4',6,6'-Hexachloro-1,1'-biphenyl- 13C12 (2,2',4,4',6,6'-Hexachlorobiphenyl- 13C12) is 13C labeled 2,2',4,4',6,6'-Hexachloro-1,1'-biphenyl .
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- HY-B0152S1
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Adenine- 13C is the 13C labeled Adenine . Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis .
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- HY-W777583
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2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6 is the 13C labeled isotope of 2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6 (HY-W777583) .
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- HY-17043S3
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Loratadine- 13C6 (SCH 29851- 13C6) is 13C labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
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- HY-W653930
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4,4'-Sulfonyldiphenol- 13C12 (Bisphenol S- 13C12) is 13C labeled 4,4'-Sulfonyldiphenol. 4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-10285S2
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Saxagliptin- 13C2 (BMS-477118- 13C2) is 13C labeled Saxagliptin. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research .
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- HY-W017522S3
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Adipic acid- 13C (Hexanedioic acid- 13C) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc .
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- HY-136406S
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Bongkrekic acid- 13C28 is the 13C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .
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- HY-78139S
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L-Xylose-1- 13C (L-(-)-Xylose-1- 13C) is the 13C labeled L-Xylose (HY-78139). L-Xylose (L-(-)-Xylose) is a rare sugar and the levorotatory form of Xylose (HY-N0537). L-Xylose can be used as a raw material for the synthesis of various drugs and bioactive molecules .
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- HY-B1227S1
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Carprofen- 13C,d3 is the deuterium and 13C labeled Carprofen . Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively .
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- HY-78139S2
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L-Xylose-5- 13C (L-(-)-Xylose-5- 13C) is the 13C labeled L-Xylose (HY-78139). L-Xylose (L-(-)-Xylose) is a rare sugar and the levorotatory form of Xylose (HY-N0537). L-Xylose can be used as a raw material for the synthesis of various drugs and bioactive molecules .
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- HY-10208S1
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Pazopanib- 13C,d3 is the deuterium and 13C labeled Pazopanib . Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively .
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- HY-14879S2
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Avibactam sodium salt- 13C5 (NXL-104- 13C5) is 13C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively .
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- HY-N0729S3
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Linoleic acid- 13C1 is the 13C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
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- HY-78139S1
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L-Xylose-2- 13C ((L-(-)-Xylose-2- 13C)) is the 13C labeled L-Xylose (HY-78139). L-Xylose (L-(-)-Xylose) is a rare sugar and the levorotatory form of Xylose (HY-N0537). L-Xylose can be used as a raw material for the synthesis of various drugs and bioactive molecules .
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- HY-12956S2
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Dinoprost- 13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
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- HY-10450S5
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Dapagliflozin- 13C6-1 is 13C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .
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- HY-B1290S3
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2-Phenylethanol- 13C2 is 13C labeled 2-Phenylethanol (HY-B1290). 2-Phenylethanol (Phenethyl alcohol) is an aromatic alcohol with a rose-like odour. 2-Phenylethanol is a flavour and fragrance compound, and can be used as a preservative and anti-microbial agent. 2-Phenylethanol has antityrosinase and antimicrobial activities .
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- HY-B0760S1
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Fenofibric acid- 13C8 (FNF acid- 13C8) is 13C labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 μM, 1.47 μM, and 1.06 μM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
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- HY-N0729S2
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Linoleic acid- 13C18 is the 13C labeled Linoleic acid. Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
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- HY-113038AS
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α-Hydroxyglutaric acid- 13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .
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- HY-B0363S1
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Nimesulide- 13C6 (R805- 13C6) is 13C labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.
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- HY-15550S1
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4'-Hydroxy diclofenac- 13C6 is the 13C labeled 4'-Hydroxy diclofenac . 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .
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- HY-121309S1
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Doxorubicinone- 13C,d3 (Adriamycin aglycone- 13C,d3) is 13C labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
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- HY-115767S
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(±)-1,2-Diolein- 13C3 (1,2-Dioleoyl-rac-glycerol- 13C3) is 13C labeled (±)-1,2-Diolein. (±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein increases myotubes Ca 2+ influx .
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- HY-W777649
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Oxypurinol- 13C, 15N2-1 (Oxipurinol- 13C, 15N2-1) is 15N and 13C labeled Oxypurinol (HY-19657). Oxipurinol, the major active metabolite of Allopurinoll (HY-B0219), is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .
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- HY-W017522S1
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Adipic acid- 13C6 (Hexanedioic acid- 13C6) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc .
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- HY-17498S3
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Atenolol- 13C6 ((RS)-Atenolol- 13C6) is 13C labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .
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- HY-A0118S1
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Naloxegol- 13C,d2 (NKTR-118- 13C,d2) is 13C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .
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- HY-14740S2
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Elvitegravir- 13C6 (GS-9137- 13C6) is 13C labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
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- HY-W015851S2
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(R)-3-Hydroxybutanoic acid- 13C4 sodium is a 13C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
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- HY-W017522S6
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Adipic acid- 13C2 (Hexanedioic acid- 13C2) is 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc .
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- HY-N6719S
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Fumonisin B1- 13C34 is the 13C labeled Fumonisin B1 (HY-N6719) . Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .
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- HY-16504S
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Treprostinil- 13C2-d1 (Sodium) (UT-15- 13C2-d1(sodium)) is deuterium and 13C labeled Treprostinil (sodium). Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
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- HY-B0497BS
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Niclosamide- 13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate . Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research . Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells . Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .
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- HY-B0512S1
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Sulfamerazine- 13C6 (RP2632- 13C6) is 13C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.
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- HY-B0122S1
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Topiramate- 13C (McN 4853- 13C) is 13C labeled Topiramate. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .
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- HY-B0227S3
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Ketoprofen- 13C6 (RP-19583- 13C6) is 13C labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .
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- HY-W008125S
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Acetobromo-a-D-glucuronic acid- 13C6 methyl ester (Methyl acetobromo-α-D-glucuronate- 13C6 methyl ester) is 13C labeled Acetobromo-α-D-glucuronic acid methyl ester, 98%. Acetobromo-α-D-glucuronic acid methyl ester, 98% (Acetobromo-alpha-D-glucuronic acid methyl ester, 98%) can be used in glycobiology research and can undergo glycosylation reactions with suitable glycoside receptors.
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- HY-B0252S2
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Hydrochlorothiazide- 13C6 is the 13C labeled Hydrochlorothiazide . Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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- HY-A0118S
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Naloxegol- 13C,d3 (NKTR-118- 13C,d3) is 13C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .
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- HY-W778391
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Bisphenol A- 13C2 is 13C labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .
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- HY-N6779S
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Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
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- HY-B1125S
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Glucosamine- 13C6 (D-Glucosamine- 13C6) is 13C labeled Glucosamine. Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
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- HY-N0368S1
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Linalool- 13C3 is 13C labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
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- HY-B0228S10
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(R)-3-Hydroxybutanoic acid- 13C2 (sodium) is the 13C labeled (R)-3-Hydroxybutanoic acid (sodium) (HY-W015851). (R)-3-Hydroxybutanoic acid (sodium) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
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- HY-W769714
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Favipiravir- 13C3 is the 13C labeled isotope of Favipiravir- 13C3(HY-14768 ).Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
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- HY-Y0921S3
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(±)-1,2-Propanediol- 13C3 is 13C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish .
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- HY-10450S3
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Dapagliflozin- 13C6 (BMS-512148- 13C6) is 13C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .
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- HY-14397S3
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Indomethacin- 13C6 (Indometacin- 13C6) is 13C labeled Indomethacin. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .
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- HY-152040S
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Tenuazonic acid-(acetyl- 13C2) (mixture of diastereomers) in methanol (3-(Acetyl- 13C2)-5-((S)-sec-butyl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one) is 13C labeled Tenuazonic acid-(acetyl) (mixture of diastereomers) in methanol .
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- HY-W654002
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(3R)-3-Hydroxybutyric acid-1- 13C is 13C labeled (R)-3-Hydroxybutanoic acid. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones .
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- HY-19717S
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DCVC- 13C3, 15N is 15N and 13C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures .
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- HY-W653989
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Desonide- 13C3 is the 13C labeled isotope of Desonide (HY-B0248). Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis .
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- HY-B0228S1
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Adenosine- 13C5 is the 13C labeled Adenosine . Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .
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- HY-B0637S2
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Bezafibrate- 13C6 (BM15075- 13C6) is 13C labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
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- HY-W021040S
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Fludioxonil- 13C3 (CGA-173506- 13C3) is 13C labeled Fludioxonil. Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells .
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- HY-W778008
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Rac-Vigabatrin- 13C,d2 (Major) is the deuterium and 13C labeled Vigabatrin (HY-15399). Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .
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- HY-14854S
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Tecarfarin- 13C,d3 (ATI-5923- 13C,d3) is 13C labeled Tecarfarin. Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X . Tecarfarin has the antithrombotic activity .
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- HY-B0256S1
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Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .
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- HY-B0421S2
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Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
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- HY-W585956
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Triclocarban- 13C6 is the 13C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
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- HY-N0803S1
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Myrcene- 13C3 is 13C labeled Myrcene (HY-N0803). Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .
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- HY-13458S2
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Droxidopa- 13C6 (L-DOPS- 13C6) is 13C labeled Droxidopa. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder) .
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- HY-103447S1
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Zearalenone- 13C18 (Mycotoxin F2- 13C18; Toxin F2- 13C18) is the 13C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .
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- HY-N0728S3
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α-Linolenic acid- 13C18 is the 13C labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .
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- HY-W018772S15
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D-Ribose(mixture of isomers)- 13C5 isomers)- 13C5 is the 13C labeled D-Ribose(mixture of isomers) . D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .
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- HY-114370S
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Selpercatinib- 13C,d3 (LOXO-292- 13C,d3) is 13C labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity .
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- HY-113420S2
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11-Dehydro-thromboxane B2- 13C5 is 13C labeled 11-Dehydro-thromboxane B2 (HY-113420). 11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis .
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- HY-N6801S
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Nivalenol- 13C15 is the 13C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .
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- HY-B1075AS
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(Rac)-Fosfomycin (benzylamine)- 13C3 is the 13C labeled Fosfomycin . Fosfomycin (MK-0955) is a broad-spectrum antibiotic. Fosfomycin can cross blood-brain barrier penetrating, and irreversibly inhibits an early stage in cell wall synthesis. Fosfomycin shows anti-bacteria activity for a range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria .
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- HY-14894S2
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Pragliflozin- 13C6 (ASP1941- 13C6) is 13C labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
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- HY-Y0051S
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5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
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- HY-W654020
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Propyl paraben- 13C6 (Propyl parahydroxybenzoate- 13C6) is 13C labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats .
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- HY-B0251S1
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Eplerenone- 13C,d3 (Epoxymexrenone- 13C,d3) is 13C labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
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- HY-17416S2
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Guanfacine- 13C,d5 hydrochloride is the deuterium and 13C labeled Guanfacine hydrochloride (HY-17416). Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) .
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- HY-10260S2
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Vandetanib- 13C6 is a 13C labeled Vandetanib (HY-10260) . Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
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- HY-18767S2
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Ivosidenib- 13C5 (AG-120- 13C5) is 13C labeled Ivosidenib. Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity .
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- HY-59354S1
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1,2-Dihydropyridazine-3,6-dione-3,4,5,6- 13C4 (1,2-Dihydro-3,6-pyridazine- 13C4-dione) is 13C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .
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- HY-Y0045S
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2-Acetylthiazole- 13C2 is 13C labeled 2-Acetylthiazole (HY-Y0045). 2-Acetylthiazole (1-(1,3-Thiazol-2-yl)ethanone; 1-(Thiazol-2-yl)ethanone; Methyl 2-thiazolyl ketone) is a flavor compound. 2-Acetylthiazole is a kind of biological materials or organic compounds that are widely used in life science research .
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- HY-W008614S1
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Lansoprazole sulfone- 13C6 (AG-1813- 13C6) is 13C labeled Lansoprazole sulfone. Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H +, K +-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H +, K +-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .
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- HY-N9484S
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Menthofuran- 13C2 is 13C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .
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- HY-14171S2
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Bexarotene- 13C6 (LGD1069- 13C6) is 13C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
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- HY-14520S2
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Tetrahydrofolic acid- 13C6 (L-5,6,7,8-Tetrahydrofolic acid- 13C6) is 13C labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
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- HY-B0158S7
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Cytidine- 13C9 (Cytosine β-D-riboside- 13C9; Cytosine-1-β-D-ribofuranoside- 13C9) is 13C labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .
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- HY-137522AS1
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Zidovudine Glucuronide- 13C6 (3'-Azido-3'-deoxythymidine β-D-glucuronide- 13C6) is 13C labeled Zidovudine O-β-D-glucuronide. Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .
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- HY-18341S4
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L-Thyroxine- 13C6-1 (Levothyroxine- 13C6-1; T4- 13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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- HY-113455S1
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9(S)-HODE- 13C18 ((+)-α-Dimophecolic acid- 13C18) is 13C labeled 9S-HODE. 9S-HODE (Alpha-dimorphecolic acid) is an octadecadienoic acid and the main active derivative of linoleic acid, which can reduce the viability of HL-60 cells and induce apoptosis. 9S-HODE is rich in lipid peroxidation (LPO) products and is almost an ideal marker for LPO .
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- HY-N6745S
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Citreoviridin- 13C23 is 13C labeled 2,3-Pentanedione (HY-W012998). 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
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- HY-B0656AS3
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Rabeprazole- 13C,d3 (sodium) (LY307640- 13C,d3 (sodium)) is 13C labeled Rabeprazole (sodium). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .
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- HY-N0322S5
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Cholesterol- 13C2 is the 13C labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .
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- HY-W013636S3
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2-Ketoglutaric acid- 13C (Alpha-Ketoglutaric acid- 13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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- HY-W013636S4
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2-Ketoglutaric acid- 13C2 (Alpha-Ketoglutaric acid- 13C2) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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- HY-W779193
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2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline-2- 13C is 13C labeled 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine. 2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine is a mutagenic compound .
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- HY-10574S1
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Rilpivirine- 13C6 (R278474- 13C6) is 13C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .
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- HY-17416AS1
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Guanfacine- 15N3, 13C2 is 15N and 13C labeled Guanfacine (HY-17416A). Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) .
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- HY-N0349S1
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Methyl Paraben- 13C6 (Methyl 4-hydroxybenzoate- 13C6) is a 13C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .
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- HY-10121S4
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Asenapine-d3, 13C (Org 5222-d3, 13C) is deuterium and 13C labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .
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- HY-W013636S
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2-Ketoglutaric acid- 13C5 (Alpha-Ketoglutaric acid- 13C5) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) .
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- HY-14520S1
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Tetrahydrofolic acid- 13C5 (L-5,6,7,8-Tetrahydrofolic acid- 13C5) is 13C labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
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- HY-U00462S
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D-Mannoheptulose- 13C is the 13C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .
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- HY-B0322S1
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Sulfamethoxazole- 13C6 (Ro 4-2130- 13C6) is a 13C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .
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- HY-W749691
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(S)-Velpatasvir- 13C,d3 ((S)-GS-5816- 13C,d3) is 13C labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
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- HY-W777582
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4-tert-Octylphenol monoethoxylate- 13C6 is the 13C labeled isotope of 4-tert-Octylphenol monoethoxylate (HY-W777582) . 4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent .
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- HY-W747703
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Hippuric acid- 13C6 (Benzoylglycine- 13C6) is 13C labeled Hippuric acid. Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research .
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- HY-113209S2
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8-Isoprostaglandin F2α- 13C5 is 13C labeled 8-Isoprostaglandin F2α (HY-113209). 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
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- HY-B2221S1
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U- 13C Cellulose from chicory is the 13C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .
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- HY-B2221S5
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U- 13C Cellulose from broccoli is the 13C labeled Cellulose (HY-B2221). Cellulose is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .
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- HY-113046S1
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5-Methyltetrahydrofolic acid- 13C6 (5-Methyl THF- 13C6) is 13C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .
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- HY-B1805S1
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Triclocarban- 13C13 (3,4,4'-Trichlorocarbanilide- 13C13) is 13C labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
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- HY-A0004S
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Decitabine- 13C5 (5-Aza-2'-deoxycytidine- 13C5) is 13C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .
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- HY-B0122S
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Topiramate-13C6 (McN 4853-13C6) is the 13C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .
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- HY-W011577S1
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Dibenzo[a,c]anthracene- 13C6 (2,3-Benzotriphenylene- 13C6) is 13C labeled Benzo[f]tetraphene. Benzo[f]tetraphene (Dibenz[a,c]anthracene) is a polycyclic aromatic hydrocarbon with significant antitumor activity. Benzo[f]tetraphene is used as a luminescent probe in cell biology research and can effectively detect reactive oxygen species in biological systems. Benzo[f]tetraphene can also be used as a potential photosensitizer and shows good application prospects in photodynamic inhibition.
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- HY-13716S
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Noscapine- 13C,d3 is a 13C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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- HY-78131S3
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Ibuprofen- 13C6 ((±)-Ibuprofen- 13C6) is a 13C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
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- HY-B0347S3
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Lacidipine- 13C4 is 13C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .
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- HY-15206S2
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Glibenclamide- 13C6 (Glyburide- 13C6) is 13C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K + channel (KATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .
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- HY-166898S
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trans Nonachlor- 13C10 is 13C labeled (1R,2R,3S,3aR,4R,7R,7aS)-1,2,3,4,5,6,7,8,8-Nonachloro-2,3,3a,4,7,7a-hexahydro-1H-4,7-methanoindene .
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- HY-13771S1
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Ursodeoxycholic acid- 13C is the 13C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active .
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- HY-B2221S
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U- 13C Cellulose high DP from potato is the 13C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .
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- HY-B2221S3
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U- 13C Cellulose high DP from maize is the 13C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .
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- HY-W007376S
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Indole-3-carboxaldehyde- 13C (3-Formylindole- 13C) is a 13C labeled Indole-3-carboxaldehyde (HY-W007376). Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde (3-Formylindole) is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin .
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- HY-B1456AS
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Fenoprofen- 13C6 (LILLY-53858- 13C6) sodium hydrate is the 13C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
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- HY-B0617S2
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S-Adenosyl-L-methionine- 13C (S-Adenosyl methionine- 13C) dihydrochloride is the 13C labeled S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .
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- HY-10218S1
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Everolimus- 13C2,d4 (RAD001- 13C2,d4) is 13C labeled Everolimus. Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .
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- HY-15236S1
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PSI-6206-d1, 13C, 15N2 is 15N and 13C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
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- HY-W747639
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Glycidyl Stearate- 13C3 is 13C labeled Glycidyl stearate. Oxiran-2-ylmethyl stearate is a compound belonging to the class of esters. It contains reactive oxirane or epoxy groups that give the molecule its unique properties. Oxiran-2-ylmethyl stearate is derived from stearic acid and epichlorohydrin, which are naturally occurring substances. Glycidyl stearate is commonly used in various industrial applications such as the production of coatings, adhesives and surfactants. It can also be used as a crosslinking agent in the manufacture of polymers and resins .
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- HY-166906S
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cis-Nonachlor- 13C10 is 13C labeled (1R,2S,3S,3aR,4R,7R,7aS)-1,2,3,4,5,6,7,8,8-Nonachloro-2,3,3a,4,7,7a-hexahydro-1H-4,7-methanoindene .
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- HY-B0124S2
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Zonisamide- 13C6 (AD 810- 13C6) is 13C labeled Zonisamide. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .
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- HY-B0580S2
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Ketorolac- 13C6 (RS37619- 13C6) is 13C labeled Ketorolac. Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research .
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- HY-B0151S1
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Pregnenolone- 13C2,d2 is the deuterium and 13C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels .
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- HY-15463S3
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Imatinib- 13C,d3 (STI571- 13C,d3) is 13C labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and MERS-CoV .
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- HY-13690S1
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Mitotane- 13C6 is the 13C labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
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- HY-N6739S
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Beauvericin- 13C45 is 13C labeled Beauvericin (HY-N6739). Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages .
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- HY-W779019
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Xylose- 13C5 (D-(+)-Xylose- 13C5) is 13C labeled Xylose. Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation .
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- HY-D0205AS1
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Carbocisteine- 13C3-1 (Carbocysteine- 13C3-1) is 13C labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research [13].
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- HY-B0579S3
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Cyclosporin A- 13C2,d4 (Cyclosporine A- 13C2,d4; Ciclosporin A- 13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .
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- HY-W653962
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Triclosan- 13C6 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
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- HY-W747491
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Triclosan- 13C12 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
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- HY-B1190S2
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Cefadroxil- 13C6 (BL-S 578- 13C6) is 13C labeled Cefadroxil (HY-B1190). Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
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- HY-N0537S3
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Xylose-2- 13C (D-(+)-Xylose-2- 13C) is the 13C labeled Xylose (HY-N0537). Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation .
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- HY-143704S
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5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
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- HY-W778207
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2'-Deoxyadenosine- 13C5 monohydrate is the 13C labeled isotope of '-Deoxyadenosine monohydrate (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer .
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- HY-130462S2
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC- 13C16 (POPC- 13C16) is 13C labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers .
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- HY-W040240S
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(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- 13C is the 13C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite .
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- HY-W014901S1
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Bisphenol F- 13C12 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) .
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- HY-W011683S3
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2'-Deoxyadenosine monohydrate-5′- 13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .
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- HY-W011683S
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2'-Deoxyadenosine monohydrate-1′- 13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .
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- HY-W011683S1
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2'-Deoxyadenosine monohydrate-2′- 13C is the 13C labeled 2'-Deoxyadenosine monohydrate(HY-W011683) . 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer .
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- HY-W014901S
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Bisphenol F- 13C6 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) .
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- HY-W040240S1
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(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- 13C-1 is the 13C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite .
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- HY-W040240S2
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(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- 13C-2 is the 13C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite .
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- HY-A0003S2
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Lenalidomide- 13C5, 15N is 15N and 13C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .
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- HY-B0166S8
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L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
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- HY-W011683S2
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2'-Deoxyadenosine monohydrate-3′- 13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer>
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- HY-N6715S
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Tenuazonic acid- 13C10 is 13C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .
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- HY-13690S3
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Mitotane- 13C12 (2,4′-DDD- 13C12) is 13C labeled Mitotane. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
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- HY-W127515S
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trans-2,cis-6-Nonadienal- 13C2 is 13C labeled trans-2,cis-6-Nonadienal (HY-W127515). Trans-2, cis-6-NonadienalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2, cis-6-NonadienalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.
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- HY-W050154S
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Kojic acid- 13C6 is 13C labeled Kojic acid (HY-W050154). Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .
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- HY-133968S1
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24-Methylenecholesterol- 13C (Ostreasterol- 13C) is the 13C labeled 24-Methylenecholesterol (HY-133968) . 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .
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- HY-W017443S4
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L-Asparagine-1,2,3,4- 13C4 monohydrate is the 13C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
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- HY-N7032S1
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Uridine 5′-diphosphoglucose- 13C6 (UDP-D-Glucose- 13C6) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .
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- HY-N7032S
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Uridine 5′-diphosphoglucose- 13C (UDP-D-Glucose- 13C) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .
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- HY-N6746S1
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Citrinin- 13C13 (NSC 186- 13C13) is the 13C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .
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- HY-18252S3
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Avanafil- 13C5 (TA1790- 13C5) is 13C labeled Avanafil. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis .
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- HY-B0710S
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Betaine- 13C3 (Trimethylglycine- 13C3) is the 13C labeled isotope of Betaine (HY-B0710). Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns [1,2]. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity .
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- HY-N0059S
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D-Arabinose- 13C is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
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- HY-B0660S1
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Eicosapentaenoic acid 1,2,3,4,5- 13C5 (EPA 1,2,3,4,5- 13C, FA 20:5- 13C5) is 13C labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .
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- HY-N0059S1
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D-Arabinose- 13C-1 is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
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- HY-N0059S2
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D-Arabinose- 13C-2 is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
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- HY-N0059S3
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D-Arabinose- 13C-3 is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
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- HY-N7082S
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D-Arabinopyranos- 13C5 is 13C labeled D-Arabinopyranos (HY-N7082). D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose (HY-N0059). D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082) .
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- HY-W009538S1
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5'-Deoxy-5-fluorocytidine-13C5 is the 13C labeled isotope of 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .
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Classification |
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- HY-14605BS
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AGN1135-13C3; TVP1012-13C3 racemic
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Alkynes
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Rasagiline- 13C3 (mesylate racemic) is a 13C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor . Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-50896S1
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CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6
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Alkynes
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Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR .
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- HY-B0216S2
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17α-Ethynylestradiol-13C2; Ethynylestradiol-13C2
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Alkynes
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Ethynyl Estradiol- 13C2 is the 13C-labeled Ethynyl Estradiol. Ethynyl Estradiol-13C2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-136380S
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Alkynes
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Clodinafop-propargyl- 13C6 is the 13C-labeled Clodinafop-propargyl. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl-13C6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-12008S1
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CP-358774-13C6 hydrochloride; NSC 718781-13C6 hydrochloride; OSI-774-13C6 hydrochloride
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Alkynes
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Erlotinib- 13C6 hydrochloride is the 13C labeled Erlotinib Hydrochloride . Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM . Erlotinib- 13C6 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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