1. Search Result
Search Result
Isoforms Recommended: Caspase 3
Results for "

Caspase-3

" in MedChemExpress (MCE) Product Catalog:

295

Inhibitors & Agonists

10

Fluorescent Dye

3

Biochemical Assay Reagents

43

Peptides

2

MCE Kits

67

Natural
Products

2

Recombinant Proteins

10

Isotope-Labeled Compounds

2

Antibodies

2

Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1095

    Caspase-3 Inhibitor VII

    Caspase Cardiovascular Disease Neurological Disease
    Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases .
    Ivachtin
  • HY-P0034A
    Ac-DEVD-CMK TFA
    2 Publications Verification

    Caspase-3 Inhibitor III TFA

    Caspase Apoptosis Metabolic Disease
    Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis [3].
    Ac-DEVD-CMK TFA
  • HY-136975

    Caspase Neurological Disease Metabolic Disease
    Caspase-3-IN-1 (compound 11b) is a potent Caspase-3 inhibitor, with an IC50 of 14.5 nM .
    Caspase-3-IN-1
  • HY-155389

    Caspase Cancer
    Caspase-3 activator 2 (Compound 2f) is a caspase 3 activator that induces apoptosis and can be used in cancer research. Caspase-3 activator 2 is cytotoxic to HL-60 cells and K562 cells, with IC50 values of 33.52 μM and 76.90 μM respectively .
    Caspase-3 activator 2
  • HY-161991

    Caspase Apoptosis Cancer
    Caspase-3 activator 4 (compound 4o) is a potent and cross the blood-brain barrier caspase-3 activator. Caspase-3 activator 4 shows antiproliferative activity. Caspase-3 activator 4 induces apoptosis. Caspase-3 activator 4 increases the gene expression of TNF-α. Caspase-3 activator 4 decreases the protein expression of cleaved caspases 3/caspases 3 .
    Caspase-3 activator 4
  • HY-155390

    Caspase Apoptosis Cancer
    Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC50 values of 42.89 and 33.61 μM, respectively .
    Caspase-3 activator 3
  • HY-P0034

    Caspase-3 Inhibitor III

    Caspase Apoptosis Metabolic Disease
    Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis [3].
    Ac-DEVD-CMK
  • HY-152748

    Apoptosis Caspase Cancer
    Caspase-3/7 activator 1 is an effective activator of Caspase-3/7. Caspase-3/7 activator 1 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability .
    Caspase-3/7 activator 1
  • HY-152756

    Apoptosis Caspase Cancer
    Caspase-3/7 activator 2 is an effective activator of Caspase-3/7. Caspase-3/7 activator 2 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability .
    Caspase-3/7 activator 2
  • HY-152758

    Apoptosis Caspase Cancer
    Caspase-3/7 activator 3 is an effective activator of Caspase-3/7. Caspase-3/7 activator 3 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability .
    Caspase-3/7 activator 3
  • HY-D1432

    Fluorescent Dye Cancer
    FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .
    FITC-C6-DEVD-FMK
  • HY-P3475

    Fluorescent Dye Others
    Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .
    Mca-VDQMDGW-K(Dnp)-NH2
  • HY-155612

    Caspase Neurological Disease
    M826 is a potent, selective and reversible non-peptide caspase-3 inhibitor with an IC50 value of 0.005 μM for enzymatic activity against caspase-3. M826 displays potent anti-apoptotic activity in animal models in vitro and in vivo. M826 can be used for nervous system diseases research .
    M826
  • HY-P3234

    Casein Kinase Others
    Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .
    Ac-ESMD-CHO
  • HY-P1094

    Apoptosis Caspase Inflammation/Immunology Cancer
    AZ-10417808 is a selective caspase-3 inhibitor. AZ-10417808 blocks apoptosis signaling pathway by inhibiting caspase-3 activity. AZ-10417808 can be used to study the effect of nicotine on plasmacytoid dendritic cell migration .
    AZ-10417808
  • HY-P10162

    Caspase Cancer
    Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) .
    Ac-DMQD-AMC
  • HY-121320
    Raptinal
    5 Publications Verification

    Caspase Apoptosis Cancer
    Raptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9 .
    Raptinal
  • HY-155613

    Caspase Cancer
    M867 is a selective and reversible inhibitor of caspase-3 with an IC50 of 1.4 nM and Ki of 0.7 nM. M867 has anti apoptotic activity .
    M867
  • HY-P1169
    Ac-IETD-AFC
    1 Publications Verification

    Caspase Others
    Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .
    Ac-IETD-AFC
  • HY-103347

    Apoptosis Inflammation/Immunology
    M50054 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC50 of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia .
    M50054
  • HY-P3363

    Caspase Cancer
    Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .
    Z-DEVD-AMC
  • HY-19696
    Tauroursodeoxycholate
    60+ Cited Publications

    Tauroursodeoxycholic acid; TUDCA; UR 906

    ERK Caspase Endogenous Metabolite Apoptosis Cancer
    Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
    Tauroursodeoxycholate
  • HY-19696A
    Tauroursodeoxycholate sodium
    60+ Cited Publications

    Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium

    ERK Caspase Apoptosis Endogenous Metabolite Cancer
    Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
    Tauroursodeoxycholate sodium
  • HY-P4900

    Caspase Others
    Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy .
    Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone
  • HY-19696B
    Tauroursodeoxycholate dihydrate
    60+ Cited Publications

    Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate

    ERK Caspase Apoptosis Endogenous Metabolite Cancer
    Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK .
    Tauroursodeoxycholate dihydrate
  • HY-147928

    Apoptosis Caspase Bcl-2 Family Cancer
    Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research .
    Apoptotic agent-2
  • HY-NP019

    Sirtuin Caspase Apoptosis Neurological Disease
    Agkistrodon halys batroxobin is a thrombin-like serine protease. Agkistrodon halys batroxobin reduces the expression of Sirt1 and extracellular signal-regulated kinase activation in brain tissue. Agkistrodon halys batroxobin reduces cleaved caspase-3 expression and inhibits neuronal apoptosis in rat .
    Agkistrodon halys batroxobin
  • HY-150696

    Apoptosis Caspase PARP Cancer
    Antitumor agent-72 (compound 6w) is a potent anticancer agent. Antitumor agent-72 has anticancer activity and induces apoptosis through activation of caspase-3 and cleavage of PARP. Antitumor agent-72 can be used for cancer research .
    Antitumor agent-72
  • HY-137371

    Bacterial Apoptosis Antibiotic Infection Cancer
    Lactonic sophorolipid is a natural antimicrobial surfactant for oral hygiene . Lactonic sophorolipid, a potential anticancer agent, induces apoptosis in human HepG2 cells through the caspase-3 pathway .
    Lactonic sophorolipid
  • HY-P10452

    Caspase Others
    Ac-LEVDGWK(Dnp)-NH2 is a substrate for Caspase-3, and can be used to detect Caspase-3 activity .
    Ac-LEVDGWK(Dnp)-NH2
  • HY-141867

    Z-Phe-Phe-FMK

    Cathepsin Neurological Disease
    Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .
    Z-FF-FMK
  • HY-124476

    Caspase Glutaminase Apoptosis Cancer
    Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [3].
    Cystamine
  • HY-W020050

    Caspase Glutaminase Apoptosis Neurological Disease Cancer
    Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [3].
    Cystamine dihydrochloride
  • HY-124344

    Interleukin Related Neurological Disease
    Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .
    Avenanthramide C
  • HY-12294

    NVP-AAM077

    Caspase Apoptosis iGluR Neurological Disease
    PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures .
    PEAQX
  • HY-108312A

    Caspase Neurological Disease
    AC-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .
    AC-VEID-CHO TFA
  • HY-117249

    AK-2123

    Apoptosis Caspase Cancer
    Sanazole (AK-2123) is a hypoxic cell radiosensitizer. Sanazole enhances radiation-induced DNA strand breaks. In mouse fibroblast tumors, Sanazole increases nuclear condensation and fragmentation, as well as elevates caspase-3 activity, thereby enhancing radiation-induced apoptosis. These characteristics make Sanazole a promising candidate for research in tumor therapy .
    Sanazole
  • HY-144604

    Formyl Peptide Receptor (FPR) Infection Neurological Disease
    FPR2 agonist 2 is a potent and permeates the blood?brain barrier FPR2 agonist with an EC50 of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity .
    FPR2 agonist 2
  • HY-P1001
    Ac-DEVD-CHO
    30+ Cited Publications

    Caspase Cancer
    Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a Ki value of 230 pM.
    Ac-DEVD-CHO
  • HY-P2614

    Caspase Others
    Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .
    Mca-DEVDAP-K(Dnp)-OH
  • HY-W792412

    Caspase Cancer
    Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor .
    Z-YVAD-CMK
  • HY-P3560

    TV 4710

    Apoptosis Inflammation/Immunology
    Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE) [3].
    Edratide
  • HY-N1157

    Apigenin-5-methyl ether

    Bcl-2 Family Caspase Neurological Disease
    Thevetiaflavone could upregulate the expression of Bcl-2 and downregulate that of Bax and caspase-3.
    Thevetiaflavone
  • HY-P6285

    Fluorescent Dye Caspase Cancer
    Z-TPE-2DEVD is a specific probe for caspase-3 .
    Z-TPE-2DEVD
  • HY-12466
    Z-DEVD-FMK
    Maximum Cited Publications
    81 Publications Verification

    Caspase Cancer
    Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM .
    Z-DEVD-FMK
  • HY-P1006
    Ac-DEVD-pNA
    1 Publications Verification

    Caspase Others
    Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.
    Ac-DEVD-pNA
  • HY-12352

    STAT Apoptosis Cancer
    HJC0416 is a potent and orally active STAT3 inhibitor. HJC0416 shows antiprolifeative activity and induces apoptosis. HJC0416 decreases the expression of p-STAT3 (Tyr-705), Cyclin D1 and increases the expression of cleaved caspase-3 protein. HJC0416 shows anti-tumor activity .
    HJC0416
  • HY-12294A
    PEAQX tetrasodium hydrate
    5 Publications Verification

    NVP-AAM077 tetrasodium hydrate

    Apoptosis Caspase iGluR Neurological Disease
    PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures .
    PEAQX tetrasodium hydrate
  • HY-P5936

    DEVD-CHO-CPP 32

    Caspase Cancer
    Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible caspase-3 inhibitor .
    Ac-AAVALLPAVLLALLAP-DEVD-CHO
  • HY-P1986

    Caspase Cancer
    Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
    Z-DEVD-AFC

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

 

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

 

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: