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NRF2

" in MedChemExpress (MCE) Product Catalog:

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145879

Nrf2 activator-2	Keap1-Nrf2	Cancer
Nrf2 activator-2 (compound O15), a Osthole derivative, is a potent *Nrf2* agonist with an EC₅₀ of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thus showing the activation effect on Nrf2. Nrf2 activator-2 shows a marked decrease in the level of ubiquitinated Nrf2 in cells .

HY-143333

Nrf2 activator-3	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Nrf2 activator-3 is a potent *Nrf2* activator. Nrf2 activator-3 is used for cerebral ischemic injury research .

HY-162307

Nrf2 degrader 1	PROTACs Keap1-Nrf2	Cancer
Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC₅₀ values of 100 nM and 40 nM, respectively .

HY-145390

Nrf2 activator-1	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis (extracted from patent WO2018109647A1) .

HY-146086

Nrf2 activator-4	Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Nrf2 activator-4 (Compound 20a) is a highly potent, orally active *Nrf2* activator with an EC₅₀ of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model .

HY-149244

Nrf2 activator-7	Keap1-Nrf2	Others
Nrf2 activator-7 (Compound 12b) is a potent *Nrf2* activator and significantly activates the *Nrf2* signaling pathway.

HY-161992

Nrf2 activator-11	Keap1-Nrf2 Apoptosis	Neurological Disease Inflammation/Immunology
Nrf2 activator-11 (compound M11) is a *Nrf2* activator with blood-brain permeability. Nrf2 activator-11 has anti-oxidation, anti-inflammation, anti-ferroptosis and anti-apoptosis. Nrf2 activator-11 can be used to study cerebral  ischemia-reperfusion (CI/R) injury models .

HY-148480

Nrf2 activator-6	Keap1-Nrf2	Cardiovascular Disease
Nrf2 activator-6, a tetrahydroisoquinoline compound, is a *Nrf2* activator. Nrf2 activator-6 has an IC₅₀ of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4) .

HY-156081

Nrf2 activator-9	Keap1-Nrf2 Apoptosis	Metabolic Disease
Nrf2 activator-9 (compound D-36) is an Nrf2 activator that inhibits oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. Nrf2 activator-9 inhibits oxLDL and HG-induced vascular endothelial cell (VEC) injury and can effectively prevent and treat atherosclerosis .

HY-P10530

Nrf2 (69-84)	Keap1-Nrf2	Neurological Disease Inflammation/Immunology Cancer
Nrf2 (69-84) is a peptide fragment of Nrf2 protein that contains the key ETGE motif, which is an important region for binding to the Kelch domain of Keap1 protein. Nrf2 (69-84) can be used to study the role of Nrf2 in the development and progression of diseases, especially in cancer, neurodegenerative diseases and inflammatory diseases .

HY-155572

Nrf2 activator-8	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-8 (compound 10e) is a *Nrf2* activator (EC₅₀=37.9 nM). Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation .

HY-124834

Nrf2 activator-10	Keap1-Nrf2 Apoptosis	Cancer
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC₅₀ is 2.7 μM) and an activator for *Nrf2. Nrf2* activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H₂O₂-induced apoptosis.

HY-173307

Nrf2 activator 19	Reactive Oxygen Species Keap1-Nrf2 Apoptosis	Cardiovascular Disease
Nrf2 activator 19 is a BBB-penetrable *NRF2/HO-1* activator. Nrf2 activator 19 exerts potent antioxidant and neuroprotective effects. Nrf2 activator 19 can also effectively reduce brain damage, reduce Reactive Oxygen Species (ROS) accumulation. Nrf2 activator 19 inhibits neuronal apoptosis. Nrf2 activator 19 promotes the recovery of neurological function and motor ability. Nrf2 activator 19 shows significant potential in ischemic stroke research .

HY-146168

Nrf2 activator-5	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-5 (compound 1) is a potent *Nrf2* activator that can attenuate H₂O₂-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities .

HY-169315

Nrf2 activator 17	Keap1-Nrf2	Cancer
Nrf2 activator 17 (compound 10) is an *Nrf2* activator that inhibits the interaction between Keap1 and Nrf2 with an IC₅₀ of < 0.1 pM. Additionally, Nrf2 activator 17 has an EC₅₀ of < 10 μM in HepG2 cells .

HY-168709

Nrf2 activator 18	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator 18 (Compound 11a) is an orally active activator for *Keap1/Nrf2/HO-1* signaling pathway, that promotes the Nrf2 nuclear translocation, and enhances the antioxidant efficacy. Nrf2 activator 18 inhibits the release of IL-6 with an IC₅₀ of 4.816 μM. Nrf2 activator 18 exhibits anti-inflammatory efficacy in mouse PM2.5-induced lung injury model .

HY-169201

Nrf2 activator-12	Keap1-Nrf2	Cancer
Nrf2 activator-12 (compund 10v) potently activates *Nrf2* (EC50=83.5 nM) and exhibits promising pharmacological properties, reversing disease progression and alleviating demyelination in an experimental autoimmune encephalomyelitis mouse model .

HY-RS16271

Nrf-2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Keap1-Nrf2	Others
Nrf-2 Mouse Pre-designed siRNA Set A includes three pairs of siRNA designed for different regions of the Nrf-2 (Mouse) gene, along with a negative control, a FAM-labeled negative control, and a positive control.

Nrf-2 Mouse Pre-designed siRNA Set A Nrf-2 Mouse Pre-designed siRNA Set A

HY-115849

Nrf2-Activator-12G	Keap1-Nrf2	Neurological Disease
Nrf2-Activator-12G (compd 12g) is an activator of *Nrf2. Nrf2-Activator-12G induces the expression of nrf2-dependentantioxidant enzymes at both mRNA and protein levels in DAergic neuronal cell. Nrf2*-Activator-12G can used in study Parkinson’s Disease .

HY-101025

Nrf2-IN-1 5 Publications Verification	Keap1-Nrf2	Cancer
Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML) .

HY-149508

Nrf2-IN-3	Keap1-Nrf2 Reactive Oxygen Species	Cancer
Nrf2-IN-3 (Compound R16) is a small-molecule *NRF2* inhibitor and increases reactive oxygen species (ROS) production. Nrf2-IN-3 selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions, leading to proteasome-dependent NRF2 degradation in cells. Nrf2-IN-3 sensitizes KEAP1-mutated tumor cells to Cisplatin (HY-17394), Gefitinib (HY-50895), and KEAP1 G333C-mutated xenograft to Cisplatin .

HY-151430

Nrf2/HO-1 activator 1	Keap1-Nrf2 ERK Akt JNK Reactive Oxygen Species	Neurological Disease
Nrf2/HO-1 activator 1 (Compound 24) is a potent *Nrf2/HO-1* activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research .

HY-151431

Nrf2/HO-1 activator 2	Keap1-Nrf2 Reactive Oxygen Species ERK Akt JNK	Neurological Disease
Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent *Nrf2/HO-1* activator. Nrf2/HO-1 activator 2 has neuroprotective and antioxidant effects through the Nrf2/HO-1 pathway mediated by phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. Nrf2/HO-1 activator 2 can be used in the research of Parkinson's disease (PD) .

HY-170867

Nrf2/HO-1 activator 3	Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species	Cardiovascular Disease
Nrf2/HO-1 activator 3 (Compound C3a) is the activator for *Nrf2* signaling pathway that promotes the *Nrf2* translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H₂O₂- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy .

HY-144635

Nrf2-ARE/hMAO-B/QR2 modulator 1	Monoamine Oxidase Keap1-Nrf2 Reactive Oxygen Species	Neurological Disease
Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC₅₀s of 8.05, 9.83 and 0.57 μM for hMAO-B, *NRF2* and *QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS* production in okadaic acid-treated mice hippocampal slices .

HY-147924

*Keap1-Nrf2-IN-11*	Keap1-Nrf2 NO Synthase ROS Kinase	Inflammation/Immunology
Keap1-Nrf2-IN-11 (compound 6k) is a *Keap1-Nrf2* inhibitor with K_D2 value of 0.21 nM. Keap1-Nrf2-IN-11 inhibits the productions of ROS and NO and the expression of TNF-α. Keap1-Nrf2-IN-11 relieves inflammations by increasing the Nrf2 nuclear translocation. Keap1-Nrf2-IN-11 can be used for anti-inflammatory research .

HY-145390A

*(R,R)-Nrf2* activator-1**	Keap1-Nrf2	Inflammation/Immunology
(R,R)-Nrf2 activator-1 is the enantiomer of Nrf2 activator-1. Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis .

HY-159495

*Keap1-Nrf2-IN-21*	Keap1-Nrf2	Metabolic Disease Cancer
Keap1-Nrf2-IN-21 (compound 4d) is a glucose metabolism inhibitor with antitumor activity. Keap1-Nrf2-IN-21 inhibits glycolytic activity of cancer cells by targeting the glycolytic pathway, especially by affecting the *Keap1-Nrf2* signaling pathway, thereby inhibiting tumor growth. Keap1-Nrf2-IN-21 exhibits cytotoxicity against the HEC1A cell line (IC₅₀=2.60 μM) .

HY-147517

*Keap1-Nrf2-IN-9*	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Keap1-Nrf2-IN-9 (compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein protein interaction) inhibitor with an IC₅₀ of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows not cytotoxic activity in ARPE19 cells .

HY-P5909

*Keap1-Nrf2* probe**	Keap1-Nrf2	Cancer
Keap1-Nrf2 probe is a *Keap1-Nrf2* probe .

HY-151362

*Keap1-Nrf2-IN-14*	Keap1-Nrf2 Reactive Oxygen Species	Inflammation/Immunology
Keap1-Nrf2-IN-14 (compound 20c) is a *KEAP1-NRF2* inhibitor that effectively disrupts the *KEAP1-NRF2* interaction (IC₅₀=75 nM) with a K_d value of 24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of *NRF2* target genes and enhances the downstream antioxidant and anti-inflammatory activities. Keap1-Nrf2-IN-14 can be used in the study of oxidative stress-related inflammation .

HY-168526

*Keap1-Nrf2-IN-24*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-24 (compound 57) is a potent *Keap1-Nrf2* inhibitor with a K_i value of 13 nM. Keap1-Nrf2-IN-24 increases the protein expression of TRXR1 and NQO1. Keap1-Nrf2-IN-24 increases the AKR1B10 mRNA expression. Keap1-Nrf2-IN-24 shows good metabolic stability .

HY-168161

*Keap1-Nrf2-IN-23*	Keap1-Nrf2	Cancer
Keap1-Nrf2-IN-23 (compound 56) is an inhibitor of the Keap1–Nrf2 PPI (IC₅₀=16.0 nM). Keap1-Nrf2-IN-23 binds to Keap1 with a K_d value of 3.07 nM. Keap1-Nrf2-IN-23 has oral activity .

HY-143893

*Keap1-Nrf2-IN-6*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-6 (compound 64) is a potent and selective Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC₅₀ of 41 nM, K_d of 68 nM .

HY-146577

*Keap1-Nrf2-IN-7*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-7 (compound 7v) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC₅₀ of 0.45 µM .

HY-146578

*Keap1-Nrf2-IN-8*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC₅₀s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1 .

HY-143892

*Keap1-Nrf2-IN-5*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC₅₀ of 4.1 µM, K_d of 3.7 µM .

HY-150578

*Keap1-Nrf2-IN-12*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-12 is a potent *Keap1-Nrf2* inhibitor with an IC₅₀ value of 2.30 µM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes .

HY-168922

*Keap1-Nrf2-IN-25*	Keap1-Nrf2 Reactive Oxygen Species Interleukin Related	Inflammation/Immunology
Keap1-Nrf2-IN-25 (Compound 19) is a potent *Keap1-Nrf2* inhibitor (IC₅₀ of 0.55 μM) with Keap1 binding affinity (K_d of 0.50 μM). Keap1-Nrf2-IN-25 activates *Nrf2, reduces ROS* and pro-inflammatory cytokines (IL-1β, IL-6). Keap1-Nrf2-IN-25 exerts protective effects against DSS (HY-116282)-induced colitis .

HY-162096

*Keap1-Nrf2-IN-17*	Keap1-Nrf2	Cancer
Keap1-Nrf2-IN-17 (compound 18) is a potent inhibitor of *Keap1-Nrf2* protein-protein interaction .

HY-139862

*Keap1-Nrf2-IN-3*	Keap1-Nrf2	Others
Keap1-Nrf2-IN-3 is a *KEAP1:NRF2* protein−protein interaction inhibitor, and with a K_d value of 2.5 nM for KEAP1 protein.

HY-152037

*AChE/Nrf2* modulator 1**	Cholinesterase (ChE) Keap1-Nrf2	Neurological Disease
AChE/Nrf2 modulator 1 is an orally active acetylcholinesterase (AChE)/nuclear factor erythroid 2-related factor 2 (Nrf2) modulator. AChE/Nrf2 modulator 1 has Nrf2 inductive activity and AChE inhibitory activity for eeAChE and hAChE with IC₅₀ values of 0.07 μM and 0.38 μM, respectively. AChE/Nrf2 modulator 1 can be used for the research of Alzheimer's disease .

HY-P5909F

*FITC-labelled Keap1-Nrf2* probe**	Keap1-Nrf2	Others
FITC-labelled Keap1-Nrf2 probe is aFITC-labeled Keap1-Nrf2 probe (HY-P5909).

HY-144099

*Keap1-Nrf2-IN-4*	E1/E2/E3 Enzyme Apoptosis	Cancer
Keap1-Nrf2-IN-4 is a potent neddylation inhibitor. Keap1-Nrf2-IN-4 exhibits potent anti-proliferation activity against MGC-803 cells (IC₅₀=2.55 µM). Keap1-Nrf2-IN-4 blocks the migration ability and induces apoptosis of gastric cancer cells. Keap1-Nrf2-IN-4 inhibits tumor growth without obvious toxicity .

HY-168065

*Keap1-Nrf2-IN-22*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-22 (compound 19) is a *Keap1-Nrf2* inhibitor， with a *K_D2* value of 42.2 nM for Keap1. Keap1-Nrf2-IN-22 can be used for the study of acute lung injury (ALI) and cerebral ischemia/reperfusion (I/R) injury .

HY-157929

*Keap1-Nrf2-IN-19*	Keap1-Nrf2	Inflammation/Immunology Cancer
Keap1-Nrf2-IN-19 (compound 33) is an oral active Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with the K_d value of 0.0014 μM. Keap1-Nrf2-IN-19 exhibits less than 50% inhibition at 30 μM against hERG and 10 μM against CYPs .

HY-147548

*Keap1-Nrf2-IN-10*	Reactive Oxygen Species	Others
Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice .

HY-170761

*KEAP1-NRF2* PPI-IN-1**	Keap1-Nrf2	Cancer
KEAP1-NRF2 PPI-IN-1 (compound 23) is an inhibitor targeting the *KEAP1-NRF2* interaction. KEAP1-NRF2 PPI-IN-1 has IC₅₀ values of 136 nM and 62 nM in the DNA damage assays of human TK6 and insect SF9 cell lines, respectively .

HY-157928

*Keap1-Nrf2-IN-18*	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-18 (Compound 22) is an orally active *Keap1-Nrf2* protein-protein interaction (PPI) inhibitor with good pharmacokinetics (PK) profiles and more potent in vivo activities in rats. Keap1-Nrf2-IN-18 has the strongest inhibitory activity in structure−activity relationship (SAR) study (K_D = 0.0029 μM) .

HY-150579

*Keap1-Nrf2-IN-13*	Keap1-Nrf2	Inflammation/Immunology Cancer
Keap1-Nrf2-IN-13 is a *Keap1-Nrf2* protein–protein interaction (PPI) inhibitor with an IC₅₀ value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530). Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122550

Artemisitene 1 Publications Verification	Piscidia erythrina L. Terpenoids Sesquiterpenes Source classification Plants Compositae	Keap1-Nrf2 Topoisomerase Apoptosis
Artemisitene, a natural derivative of Artemisinin, is a *Nrf2* activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability ^[2].

HY-N2292

Kinsenoside 3 Publications Verification	Structural Classification Natural Products Classification of Application Fields Orchidaceae Plants Anoectochilus Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Apoptosis
Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

HY-113556

Sappanone A 4 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Plants Disease Research Fields Inflammation/Immunology Isoflavones	NF-κB Keap1-Nrf2
Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of *Nrf2* and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma .

HY-19543

Brusatol 30+ Cited Publications NSC 172924	Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Cancer	Keap1-Nrf2 Apoptosis
Brusatol (NSC?172924) is a unique inhibitor of the *Nrf2* pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis ^[2].

HY-W009731

Dibenzoylmethane	Structural Classification Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	Keap1-Nrf2
Dibenzoylmethane, a minor ingredient in licorice, activates *Nrf2* and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-131592

Tricetin 1 Publications Verification	Flavonols Structural Classification Flavonoids Cupressaceae Thuja occidentalisLinn. Neurological Disease Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis Keap1-Nrf2
Tricetin is a potent competitive inhibitor of the *Keap1-Nrf2* Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway .

HY-N3847

Eriodictyol-7-O-glucoside Eriodictyol 7-O-β-D-glucoside	Flavonoids Classification of Application Fields Labiatae Flavonones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Petalostemun purpureum	Keap1-Nrf2
Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is a potent free radical scavenger. Eriodictyol-7-O-glucoside is also an *Nrf2* activator, confers protection against Cisplatin-induced toxicity .

HY-N7617

Toralactone 1 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Cassia obtusifolia L. Source classification Phenols Polyphenols Caesalpiniaceae Plants Disease Research Fields Cancer	Keap1-Nrf2
Toralactone, isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism .

HY-N0414

Trigonelline 4 Publications Verification Trigenolline	Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Alkaloids Microorganisms other families Leguminosae Trigonella foenum-graecum Linn. Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent *Nrf2* inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-W009731R

Dibenzoylmethane (Standard)	Structural Classification Leguminosae Ketones, Aldehydes, Acids Source classification Plants Glycyrrhiza uralensis Fisch.	Keap1-Nrf2
Dibenzoylmethane (Standard) is the analytical standard of Dibenzoylmethane. This product is intended for research and analytical applications. Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .

HY-N0415

Trigonelline chloride 4 Publications Verification Trigonelline hydrochloride	Infection Alkaloids Structural Classification Classification of Application Fields Labiatae Source classification Pyridine Alkaloids Metabolic Disease Lactuca perennis Plants Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent *Nrf2* inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0643

Carnosol 10+ Cited Publications	Structural Classification Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Food Preservation Research Source classification Plants Agricultural Research Terpenoids Labiatae Phenols Polyphenols Diterpenoids Disease Research Fields Cancer	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol is a potent Ribosomal S6 Kinase *(RSK2)* inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a *Nrf2* activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) ^[2] .

HY-N12486

Isofalcarintriol	Structural Classification Natural Products Source classification Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Plants Umbelliferae	Keap1-Nrf2 ATP Synthase
Isofalcarintriol is a *NRF2* activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-N0414R

Trigonelline (Standard)	Alkaloids Structural Classification Microorganisms other families Leguminosae Source classification Pyridine Alkaloids Plants Endogenous metabolite Trigonella foenum-graecum Linn.	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N0415R

Trigonelline (chloride) (Standard)	Alkaloids Structural Classification Labiatae Source classification Pyridine Alkaloids Lactuca perennis Plants	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0509

Astilbin 2 Publications Verification	Flavanonols Structural Classification Flavonoids Microorganisms other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Keap1-Nrf2 TNF Receptor NF-κB
Astilbin is a flavonoid compound and enhances *NRF2* activation. Astilbin also suppresses TNF-α expression and NF-κB activation.

HY-N1244

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Structural Classification Natural Products Animals Source classification Saccharides Monosaccharides	Keap1-Nrf2 mTOR Apoptosis
Sarmentosin is an activator of *Nrf2. Sarmentosin inhibits mTOR* signaling and induces autophagy-dependent apoptosis in human HCC cells .

HY-N15361

Palythine	Structural Classification Natural Products Marine natural products Source classification Sponge	Keap1-Nrf2
Palythine is a photoprotective and antioxidant agent. Palythine exhibits photoprotective and antioxidant activities by absorbing ultraviolet radiation (UVR) energy and dissipating it as heat, as well as through antioxidant mechanisms such as direct chemical quenching and Nrf2 pathway activation, reducing cell death, DNA damage, inflammation, and oxidative stress. Palythine is promising for research of skin-related diseases such as skin cancer, photoaging, and photosensitivity disorders .

HY-N0643R

Carnosol (Standard)	Structural Classification Paramacrolobium coeruleum (Taub.) J.Léonard Terpenoids Labiatae Source classification Phenols Polyphenols Diterpenoids Plants	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) ^[2] .

HY-N3260

Methyllucidone	Structural Classification Natural Products Source classification Plants Lauraceae	Reactive Oxygen Species Keap1-Nrf2 PI3K
Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino. Methyllucidone inhibits the ROS production, and activates antioxidant signaling pathways that include *Nrf-2* and PI3K .

HY-13755

Sulforaphane 45+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	HDAC Keap1-Nrf2 Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species
Sulforaphane is an orally active inducer of the *Keap1/Nrf2/ARE* pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties ^[2] .

HY-N15190

Sesaminol	Structural Classification Acanthaceae Source classification Lignans Justicia procumbens Linnaeus Phenylpropanoids Plants	Keap1-Nrf2 Reactive Oxygen Species
Sesaminol is an orally active activator for *Nrf2-ARE* pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA (HY-B1081)-induced ROS production and apoptosis in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756)-induced Parkinson's disease .

HY-N1902

4-Hydroxyphenylacetic acid	Structural Classification Human Gut Microbiota Metabolites Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Plants Compositae Endogenous metabolite Erythrina latissima E. Mey. Disease Research Fields	Keap1-Nrf2 Endogenous Metabolite
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of *Nrf2* .

HY-N0606

Ginsenoside Rh3 1 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	Keap1-Nrf2
Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells induces *Nrf2* activation.

HY-N0892

AKBA 2 Publications Verification Acetyl-11-keto-β-boswellic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Endogenous Metabolite
AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

HY-122936

Tanshindiol C	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Histone Methyltransferase Keap1-Nrf2 Sirtuin
Tanshindiol C is a S-adenosylmethionine-competitive *EZH2* (Histone Methyltransferase) inhibitor with an IC₅₀ of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both *Nrf2* and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research ^[2].

HY-N1902R

4-Hydroxyphenylacetic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Source classification Phenols Plants Compositae Endogenous metabolite Erythrina latissima E. Mey.	Keap1-Nrf2 Endogenous Metabolite
4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of *Nrf2* . IC₅₀ & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 .

HY-N4068

Glucoraphanin 5+ Cited Publications	Structural Classification Cruciferous vegetables Classification of Application Fields Other Alkaloids Source classification Glucosinolates Plants Brassicaceae Disease Research Fields Cancer	Reactive Oxygen Species Endogenous Metabolite
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.

HY-N0826

Corynoline 5 Publications Verification	Alkaloids Structural Classification other families Neurological Disease Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Cholinesterase (ChE) Keap1-Nrf2
Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 30.6 μM . Corynoline exhibits anti-inflammatory activity by activating *Nrf2* ^[2].

HY-120912

Gingerenone A	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase Ferroptosis
Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice ^[2] .

HY-N0625A

Alpinetin 4 Publications Verification	Structural Classification Alpinia katsumadai Hayata Classification of Application Fields Source classification Plants Monophenols Flavonoids Flavonones Phenols Inflammation/Immunology Disease Research Fields Zingiberaceae Cancer	PPAR Keap1-Nrf2 Toll-like Receptor (TLR)
Alpinetin is a flavonoid isolated from cardamom and possesses antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective properties. Alpinetin inhibits lipopolysaccharide (LPS)-induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury ^[2] .

HY-N0651

Spinosin	Structural Classification Flavonoids Flavones Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Source classification Phenols Polyphenols Plants Rhamnaceae	Amyloid-β
Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ_1-42's production and combination ^[2] ^{[3 ]}.

HY-W011370

Pelargonidin chloride	Structural Classification Anthocyans Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Phaseolus vulgaris Linn. Disease Research Fields	Reactive Oxygen Species
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment ^[2] .

HY-N7029

3',4',5',5,7-Pentamethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Bauhinia championii (Benth.) Benth. Plants Disease Research Fields Cancer	Others
3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic agents by inhibition of Nrf2 pathway .

HY-13755A

(R)-Sulforaphane L-Sulforaphane	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species NF-κB
(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including *Nrf2, NF-κB, and AP-1*. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses ^[2] .

HY-N12344

n-Butyl α-D-fructofuranoside	Structural Classification Natural Products other families Source classification Plants Pteris multifida Poir.	JNK
n-Butyl α-D-fructofuranoside, isolated from the root barks of Ulmus davidiana var. japonica, enhances Nrf2 activity through activation of JNK and has antiinflammation activity ^[2].

HY-N0509R

Astilbin (Standard)	Flavanonols Structural Classification Flavonoids Microorganisms other families Source classification Phenols Polyphenols Plants	Keap1-Nrf2 TNF Receptor NF-κB
Astilbin (Standard) is the analytical standard of Astilbin. This product is intended for research and analytical applications. Astilbin is a flavonoid compound and enhances NRF2 activation. Astilbin also suppresses TNF-α expression and NF-κB activation.

HY-N0028

Forsythiaside A 3 Publications Verification	Structural Classification Oleaceae Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields	Others
Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ_25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice. Forsythiaside A inhibits the interaction between KLRB1 and CLEC2D ^[2] .

HY-N0028R

Forsythiaside A (Standard)	Structural Classification Oleaceae Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants	Others
Forsythiaside A (Standard) is the analytical standard of Forsythiaside A. This product is intended for research and analytical applications. Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice ^[2] .

HY-B2230

Hinokitiol 5+ Cited Publications β-Thujaplicin	Infection Structural Classification Cupressaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Chamaecyparis obtusa	Keap1-Nrf2 DNA Methyltransferase Virus Protease
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces *Nrf2* expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-N0637

Eriodictyol 4 Publications Verification Huazhongilexone	Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids other families Microorganisms Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Influenza Virus DNA/RNA Synthesis Endogenous Metabolite
Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces *Nrf2* signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 18 nM.

HY-N0290

Mangiferin 10+ Cited Publications	Structural Classification Liliaceae Xanthones Classification of Application Fields Source classification Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields Cancer	NF-κB Keap1-Nrf2 Apoptosis
Mangiferin is a *Nrf2* activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities ^[2] .

HY-116807

Dihydrolipoic Acid 1 Publications Verification DHLA	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reactive Oxygen Species
Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression ^[2].

HY-N4118

Cephaeline 1 Publications Verification (-)-Cephaeline; NSC 32944 free base	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Filovirus Flavivirus Keap1-Nrf2 Ferroptosis Reactive Oxygen Species
Cephaeline ((-)-Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting *NRF2* to exert anti-lung cancer efficacy ^[2] .

HY-N11657

Sanggenon A Sanggenone A	Structural Classification Flavonoids Source classification Morus alba L. Plants Moraceae Other Flavonoids	NF-κB Keap1-Nrf2
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide .

HY-N0745

Senkyunolide I	Natural Products Classification of Application Fields Source classification Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields Inflammation/Immunology	Caspase
Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3 ^[2].

HY-N10313

Dehydrobruceine B	Structural Classification Natural Products Microorganisms Source classification	Bcl-2 Family Keap1-Nrf2 Apoptosis
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses *Keap1-Nrf2* .

HY-124941

7-Deacetylgedunin	Structural Classification Natural Products Toona sinensis (A. Juss.) Roem. Source classification Plants Meliaceae	Keap1-Nrf2 Reactive Oxygen Species
7-Deacetylgedunin is an activator of *Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1* expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro .

HY-125129

Carlinoside	Structural Classification Flavonoids Classification of Application Fields Flavones Cymbopogon citratus Gramineae Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Keap1-Nrf2
Carlinoside is a flavone glycoside with hepatoprotective efficiency. Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. Carlinoside has the potential to intervene hyperbilirubinemia due to liver dysfunction .

HY-N0892R

AKBA (Standard)	Triterpenes Structural Classification Terpenoids Boswellia serrata Plants Burseraceae	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Endogenous Metabolite
AKBA (Standard) is the analytical standard of AKBA. This product is intended for research and analytical applications. AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

Cat. No.	Product Name	Chemical Structure

HY-17376S

Ezetimibe-d4
Ezetimibe-d₄ is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17363S

Dimethyl fumarate-d6
Dimethyl fumarate-d₆ is a deuterium labeled Dimethyl fumarate. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression[1][2][3][4][5][6].

HY-N1902S

4-Hydroxyphenylacetic acid-d6
4-Hydroxyphenylacetic acid-d₆ is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

HY-17376S1

Ezetimibe-d4-1
Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-14664CS

(3S,5R)-Fluvastatin-d6 sodium
(3S,5R)-Fluvastatin-d₆ (sodium) is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

HY-112675S

4-Octyl itaconate-13C5-1
4-Octyl itaconate- ¹³C₅-1 is ¹³C-labeled 4-Octyl itaconate (HY-112675). Itaconate is an anti-inflammatory metabolite that activates *Nrf2* via alkylation of KEAP1.

HY-N1902S1

4-Hydroxyphenylacetic acid-d4
4-Hydroxyphenylacetic acid-d₄ is the deuterium labeled 4-Hydroxyphenylacetic acid[1]. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[2].

HY-B1971S1

Deltamethrin-d6
Deltamethrin-d₆ (Decamethrin-d₆) is deuterium labeled Deltamethrin. Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control ^[2] .

HY-14664DS

(3S,5R)-Fluvastatin-d6
(3S,5R)-Fluvastatin-d₆ is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

HY-D0205AS2

Carbocisteine-d3
Carbocisteine-d₃ (Carbocysteine-d₃) is deuterium labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and *ERK1/2. Carbocisteine modulates Nrf2/HO-1* and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research ^[2] .

HY-N0761AS

trans-Isoferulic acid-d3

trans-Isoferulic acid-d₃ is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].

HY-12519S

Oltipraz-d3
Oltipraz-d₃ is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

HY-D0205AS1

Carbocisteine-13C3-1

Carbocisteine- ¹³C₃-1 (Carbocysteine- ¹³C₃-1) is ¹³C labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research ^[2] .

HY-17363S1

Dimethyl fumarate-d2

Dimethyl fumarate-d₂ is the deuterium labeled Dimethyl fumarate[1]. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[2][3].

HY-14649S5

Retinoic acid-d3

Retinoic acid-d₃ is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha ^[2] .

HY-14649S6

Retinoic acid-d3-1

Retinoic acid-d₃-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha ^[2] .

HY-14649S2

11-cis-Retinoic Acid-d5

11-cis-Retinoic Acid-d₅ is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].

HY-14649S4

Retinoic acid-d5

Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha ^[2] .

HY-W747703

Hippuric acid-13C6

Hippuric acid- ¹³C₆ (Benzoylglycine- ¹³C₆) is ¹³C labeled Hippuric acid. Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research ^[2] . .

HY-14649S3

Retinoic acid-d6

Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-N0005S1

Curcumin-d3

Curcumin-d₃ (Diferuloylmethane-d₃ ) is deuterium labeled Curcumin. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator ^[2] . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-B1328S1

Pyridoxine-d3
Pyridoxine-d3 is a deuterium labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway ^[2].

HY-N0682S1

Pyridoxine-d2 hydrochloride
Pyridoxine-d₂ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1328S2

Pyridoxine-d2
Pyridoxine-d₂ (Pyridoxol-d₂) is deuterium labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1328S3

Pyridoxine-13C4
Pyridoxine- ¹³C₄ (Pyridoxol- ¹³C₄) is ¹³C labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0682S

Pyridoxine-d3 hydrochloride
Pyridoxine-d₃ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-B1328S

Pyridoxine-d5
Pyridoxine-d₅ (Pyridoxol-d₅) is a deuterium labeled Pyridoxine (HY-B1328). Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0682S3

Pyridoxine-13C4 hydrochloride
Pyridoxine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

HY-N0682S2

Pyridoxine-d5 hydrochloride
Pyridoxine-d₅ (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride[1]. Pyridoxine hydrochloride (Pyridoxol;Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol;Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway[2].

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