Il6 - interleukin 6 Gene

Mus musculus

Also known as Il-6

Gene ID: 16193 | Gene type: protein coding

About Il6

Chromosome 5: 30,218,112-30,224,979 forward strand.GRCm39:CM000998.3

This gene has 4 transcripts (splice variants), 162 orthologues and is associated with 127 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Il6 Products(2)

mRNA	Protein	Name
NM_031168.2	NP_112445.1	interleukin-6 isoform 1 precursor
NM_001314054.1	NP_001300983.1	interleukin-6 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	1373998	MGI
enables interleukin-6 receptor binding	IDA IDA: Inferred from direct assay	1312474	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9637508	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell activation	IGI IGI: Inferred from genetic interaction	18792410	MGI
involved in T follicular helper cell differentiation	IMP IMP: Inferred from mutant phenotype	23045607	MGI
involved in T-helper 17 cell lineage commitment	IDA IDA: Inferred from direct assay	27893700	MGI
involved in T-helper 17 cell lineage commitment	IMP IMP: Inferred from mutant phenotype	16990136	MGI
acts upstream of T-helper 2 cell differentiation	IDA IDA: Inferred from direct assay	12594267	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IDA IDA: Inferred from direct assay	11275690	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	11275690	MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus	IDA IDA: Inferred from direct assay	21072211	MGI
acts upstream of or within cellular response to interleukin-1	IDA IDA: Inferred from direct assay	19955433	MGI
involved in cellular response to interleukin-17	IDA IDA: Inferred from direct assay	30294880	MGI
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19047410	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	19955433	MGI
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	23045607	MGI
acts upstream of or within defense response to protozoan	IMP IMP: Inferred from mutant phenotype	17109471	MGI
involved in endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	18719127	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IDA IDA: Inferred from direct assay	11275690	MGI
acts upstream of or within positive effect gene expression	IDA IDA: Inferred from direct assay	20504903	MGI
involved in germinal center B cell differentiation	IMP IMP: Inferred from mutant phenotype	23045607	MGI
involved in glucagon secretion	IMP IMP: Inferred from mutant phenotype	18719127	MGI
involved in glucose homeostasis	IDA IDA: Inferred from direct assay	22037645	MGI
acts upstream of or within glucose homeostasis	IGI IGI: Inferred from genetic interaction	24332041	MGI
involved in hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	8910279	MGI
involved in inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	MGI
acts upstream of or within interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	1312474	MGI
involved in interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	16330325	MGI
involved in interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	8910279	MGI
involved in liver regeneration	IMP IMP: Inferred from mutant phenotype	8910279	MGI
acts upstream of or within muscle cell cellular homeostasis	IGI IGI: Inferred from genetic interaction	18056981	MGI
acts upstream of or within myeloid cell homeostasis	IMP IMP: Inferred from mutant phenotype	24357729	MGI
involved in negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	11159963	MGI
acts upstream of or within negative regulation of chemokine production	IDA IDA: Inferred from direct assay	12925700	MGI
acts upstream of or within negative regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	12925700	MGI
acts upstream of or within negative regulation of hormone secretion	IDA IDA: Inferred from direct assay	7867561	MGI
involved in negative regulation of interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11159963	MGI
acts upstream of or within neutrophil apoptotic process	IDA IDA: Inferred from direct assay	12925700	MGI
acts upstream of or within neutrophil apoptotic process	IMP IMP: Inferred from mutant phenotype	12925700	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1373998	MGI
involved in positive regulation of T-helper 2 cell cytokine production	IMP IMP: Inferred from mutant phenotype	11159963	MGI
acts upstream of or within positive regulation of T-helper 2 cell differentiation	IDA IDA: Inferred from direct assay	12594267	MGI
acts upstream of or within positive regulation of cell proliferation in bone marrow	IGI IGI: Inferred from genetic interaction	21048959	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	11275690	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11275690	MGI
acts upstream of or within positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	7959007	MGI
involved in positive regulation of gliogenesis	IMP IMP: Inferred from mutant phenotype	26134658	MGI
involved in positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	23045607	MGI
involved in positive regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	25362566	MGI
involved in positive regulation of interleukin-21 production	IDA IDA: Inferred from direct assay	23045607	MGI
involved in positive regulation of receptor signaling pathway via STAT	IMP IMP: Inferred from mutant phenotype	8910279	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16330325	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19666510	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11275690	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	18056981	MGI
involved in regulation of glucagon secretion	IDA IDA: Inferred from direct assay	22037645	MGI
involved in regulation of insulin secretion	IDA IDA: Inferred from direct assay	22037645	MGI
involved in response to activity	IDA IDA: Inferred from direct assay	22037645	MGI
acts upstream of or within response to wounding	IDA IDA: Inferred from direct assay	19404405	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11275690	MGI
is active in extracellular space	IDA IDA: Inferred from direct assay	27830702	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	1577194	MGI
part of interleukin-6 receptor complex	IDA IDA: Inferred from direct assay	27893700	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il6 Protein Structure

IL6

0
100
211 a.a.

Protein Preferred Names

Protein Names

interleukin-6

B-cell hybridoma growth factor

interleukin HP-1

Recombinant Il6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7063	IL-6 Protein, Mouse	P08505 (F25-T211)	≥95%
HY-P7378	IL-6 Protein, Mouse (CHO, His)	P08505 (F25-T211)	≥95%
HY-P700216AF	Animal-Free IL-6 Protein, Mouse (His)	P08505 (F25-T211)	≥95%
HY-P7063A	IL-6 Protein, Mouse (His)	P08505 (F25-T211)	≥95%

Related Agents

Approval

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0260	Methylprednisolone		99.75%	Yes
HY-A0031	Bazedoxifene	Modulator	98.70%	Yes
HY-A0036	Bazedoxifene acetate	Modulator	99.98%	Yes
HY-B1402	Hydrocortisone hemisuccinate	Inhibitor	99.83%	Unkown
HY-B1350A	Fusidic acid sodium salt	Inhibitor	99.64%	Yes
HY-B0367	Lornoxicam		99.36%	Unkown
HY-B0667	Balsalazide	Inhibitor	99.34%	Yes
HY-B0446	Naphazoline hydrochloride		98.12%	Unkown
HY-B0513	Methylthiouracil	Inhibitor	≥98.0%	Unkown
HY-B1402B	Hydrocortisone hemisuccinate sodium	Inhibitor	99.66%	Unkown
HY-111326A	Naphazoline nitrate		≥98.0%	Unkown
HY-B0667A	Balsalazide sodium hydrate	Inhibitor	99.61%	Yes
HY-A0031A	Bazedoxifene hydrochloride	Modulator	/	Unkown
HY-111326	Naphazoline		/	Unkown
HY-B1402A	Hydrocortisone hemisuccinate hydrate	Inhibitor	/	Unkown
HY-B1402R	Hydrocortisone hemisuccinate (Standard)		/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9917	Tocilizumab	Antagonist	99.67%	Unkown
HY-P9956	Siltuximab		≥99.0%	Unkown
HY-P99165	Teprotumumab	Inhibitor	99.46%	Unkown
HY-P99111	Golimumab		99.71%	Unkown
HY-P9916	Sarilumab	Inhibitor	98.37%	Unkown
HY-P99112	Satralizumab	Inhibitor	99.82%	Unkown

Clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114360AS1	Taurohyodeoxycholic acid-d4 sodium	Inhibitor	/	Phase 4
HY-11109	Resatorvid	Inhibitor	99.95%	Phase 3
HY-146244	Agatolimod	Agonist	/	Phase 3
HY-145564	Emprumapimod	Inhibitor	99.12%	Phase 3
HY-13740	Resiquimod		99.95%	Phase 2
HY-113066A	Guanosine 5'-diphosphate disodium salt	Activator	≥99.0%	Phase 2
HY-110133	JTE-607	Inhibitor	99.27%	Phase 2
HY-147041	Selvigaltin	Inhibitor	98.87%	Phase 2
HY-15509A	Semapimod tetrahydrochloride	Inhibitor	98.43%	Phase 2
HY-108039	Bezisterim	Inhibitor	≥95.0%	Phase 2
HY-N9965	2'-Fucosyllactose	Inhibitor	99.95%	Phase 2
HY-113066C	Guanosine 5'-diphosphate (sodium), 96% (HPLC)	Activator	99.88%	Phase 2
HY-113066	Guanosine 5'-diphosphate	Activator	/	Phase 2
HY-107390	AX-024	Inhibitor	99.29%	Phase 1
HY-107390A	AX-024 hydrochloride	Inhibitor	99.75%	Phase 1
HY-P3412	MMI-0100		98.83%	Phase 1

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99316	Sirukumab	Inhibitor	95.00%	Phase 3
HY-P99210	Olokizumab	Inhibitor	/	Phase 3
HY-P99252	Itolizumab		/	Phase 3
HY-P99505	Ziltivekimab	Inhibitor	/	Phase 3
HY-P990012	Vamikibart	Inhibitor	/	Phase 3
HY-P99012	Clazakizumab	Inhibitor	/	Phase 3
HY-P99702	Levilimab	Inhibitor	/	Phase 3
HY-P99385	Vobarilizumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (223)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-102084	LMT-28	Inhibitor	98.93%	Unkown
HY-N0560	Oroxylin A		99.87%	Unkown
HY-141537	ABR-238901	Inhibitor	98.71%	Unkown
HY-15614	SC144		98.50%	Unkown
HY-N0633	Muscone	Inhibitor	≥98.0%	Unkown
HY-100339	GSK583	Inhibitor	98.74%	Unkown
HY-N0029	Forsythoside B		99.99%	Unkown
HY-W007376	Indole-3-carboxaldehyde		99.96%	Unkown
HY-19744	T6167923	Inhibitor	99.08%	Unkown
HY-N0236	Corylin	Inhibitor	99.97%	Unkown
HY-N0405	Orientin	Inhibitor	99.73%	Unkown
HY-110126	AR-C118925XX	Antagonist	≥99.0%	Unkown
HY-N0619	Mulberroside A	Inhibitor	99.86%	Unkown
HY-100544	FLLL32		99.78%	Unkown
HY-101448	TMI-1		99.59%	Unkown
HY-150738	ODN 2088	Antagonist	90.41%	Unkown
HY-N0936	Coixol	Inhibitor	99.58%	Unkown
HY-N1949	Homoplantaginin	Inhibitor	99.90%	Unkown
HY-B0141S1	Estradiol-d4	Agonist	99.55%	Unkown
HY-19999A	PF-CBP1 hydrochloride	Inhibitor	99.99%	Unkown
HY-N0710	alpha-Cyperone		99.80%	Unkown
HY-N0569	Madecassic acid	Inhibitor	99.23%	Unkown
HY-N0604	Ginsenoside Rh1	Inhibitor	≥98.0%	Unkown
HY-N2007	Veratric acid	Inhibitor	99.99%	Unkown
HY-124750	NecroX-7	Inhibitor	99.69%	Unkown
HY-Y0148	10-Hydroxydecanoic acid	Inhibitor	98.77%	Unkown
HY-15614A	SC144 hydrochloride		99.34%	Unkown
HY-N0897	Corylifol A	Inhibitor	99.90%	Unkown
HY-113330	12S-HHT	Agonist	≥99.0%	Unkown
HY-N0314	Pectolinarin		99.89%	Unkown
HY-114360A	Taurohyodeoxycholic acid sodium	Inhibitor	99.60%	Unkown
HY-N4288	4-Methylesculetin	Inhibitor	98.21%	Unkown
HY-N7674	Angoline	Inhibitor	99.67%	Unkown
HY-128598	MD2-TLR4-IN-1	Inhibitor	99.62%	Unkown
HY-113402A	Gamma-glutamylcysteine TFA		95.20%	Unkown
HY-152956	STING agonist-23	Agonist	99.16%	Unkown
HY-N2086	Ethyl palmitate	Inhibitor	99.05%	Unkown
HY-153190	W1131		99.25%	Unkown
HY-W082785A	L6H21		99.46%	Unkown
HY-150738C	ODN 2088 sodium	Antagonist	90.41%	Unkown
HY-150538	STAT3-IN-12		99.92%	Unkown
HY-N1356	Reticuline	Inhibitor	98.91%	Unkown
HY-N6246	Asperulosidic Acid	Inhibitor	99.72%	Unkown
HY-113953	Z-Asp-CH2-DCB	Inhibitor	99.28%	Unkown
HY-N8146	Bruceantinol	Inhibitor	98.89%	Unkown
HY-W041489	Chelidonic acid	Inhibitor	99.91%	Unkown
HY-145846	iNOs-IN-1	Inhibitor	99.83%	Unkown
HY-N2572	Nepetin		99.51%	Unkown
HY-B0141S	Estradiol-d3	Agonist	98.60%	Unkown
HY-112338	C188	Inhibitor	≥97.0%	Unkown
HY-126421	Kansuinine A	Inhibitor	99.81%	Unkown
HY-P10284	S7	Antagonist	99.12%	Unkown
HY-153254	BMS905	Inhibitor	99.59%	Unkown
HY-U00460	3,6-DMAD hydrochloride	Inhibitor	99.50%	Unkown
HY-146066	α7 nAchR-JAK2-STAT3 agonist 1		99.54%	Unkown
HY-B0260R	Methylprednisolone (Standard)		99.67%	Unkown
HY-N7652	Terminolic acid	Inhibitor	99.63%	Unkown
HY-148706	STAT3-IN-17	Inhibitor	≥98.0%	Unkown
HY-150744A	ODN 24888 sodium		93.10%	Unkown
HY-N0857	Deoxyandrographolide	Activator	99.87%	Unkown
HY-N7275	Di-O-methyldemethoxycurcumin	Inhibitor	97.64%	Unkown
HY-N9315	Episappanol	Inhibitor	98.57%	Unkown
HY-P0317	Interleukin (IL)-6 Receptor		98.03%	Unkown
HY-23119	Sodium thiocyanate, GR, 99%		99.14%	Unkown
HY-13740S	Resiquimod-d5		99.84%	Unkown
HY-129113	α-Chaconine	Inhibitor	99.04%	Unkown
HY-131688	2-Chlorohexadecanoic acid		99.88%	Unkown
HY-150745	ODN 24987	Inhibitor	/	Unkown
HY-150745A	ODN 24987 sodium		92.42%	Unkown
HY-B0141S2	Estradiol-d5	Agonist	99.88%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-146564A	HP210	Modulator	98.96%	Unkown
HY-152959	STING agonist-26	Agonist	99.56%	Unkown
HY-155335	FPR2 agonist 3	Agonist	99.39%	Unkown
HY-B0260S3	Methylprednisolone-d7		99.73%	Unkown
HY-N1940	β-Anhydroicaritin	Inhibitor	99.09%	Unkown
HY-N6927	Isoforskolin	Inhibitor	≥98.0%	Unkown
HY-P1117	MMK1		99.22%	Unkown
HY-134353B	ADP-β-S trilithium	Activator	85.30%	Unkown
HY-153190A	W1131 TFA		99.27%	Unkown
HY-B0141S3	Estradiol-d2	Agonist	99.44%	Unkown
HY-113066S2	Guanosine 5'-diphosphate-d13 dilithium	Activator	/	Unkown
HY-115910A	Y13g dihydrochloride	Inhibitor	99.89%	Unkown
HY-146564	R-HP210		98.21%	Unkown
HY-147506	NOD2 antagonist 1	Antagonist	99.57%	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-151876	Glucocorticoid receptor modulator 1		99.79%	Unkown
HY-153579	Anti-inflammatory agent 42	Inhibitor	≥98.0%	Unkown
HY-156025	HCAR2 agonist 1		/	Unkown
HY-169004	CBT-295	Inhibitor	99.34%	Unkown
HY-N0569R	Madecassic acid (Standard)	Inhibitor	/	Unkown
HY-N0619A	cis-Mulberroside A	Inhibitor	≥96.0%	Unkown
HY-N0811	Anemarsaponin B	Inhibitor	/	Unkown
HY-N7674A	Angoline hydrochloride	Inhibitor	/	Unkown
HY-N8413	Chlojaponilactone B	Inhibitor	≥98.0%	Unkown
HY-103438	BIBU1361	Inhibitor	/	Unkown
HY-103438A	BIBU1361 dihydrochloride		/	Unkown
HY-111077	INCB16562	Inhibitor	/	Unkown
HY-111164	CBS-3595	Inhibitor	/	Unkown
HY-113066B	Guanosine 5'-diphosphate ditromethamine	Activator	/	Unkown
HY-113066S1	Guanosine 5'-diphosphate-13C10 dilithium	Activator	/	Unkown
HY-113066S3	Guanosine 5'-diphosphate-13C10,15N5 dilithium	Activator	/	Unkown
HY-114592	M199		/	Unkown
HY-115910	Y13g	Inhibitor	/	Unkown
HY-115913	PDE4-IN-6	Inhibitor	/	Unkown
HY-115976	COX-2-IN-10	Inhibitor	/	Unkown
HY-116227	(2S,3R)-LP99	Inhibitor	/	Unkown
HY-122767	Romurtide	Activator	/	Unkown
HY-123522	PAT-048	Inhibitor	/	Unkown
HY-126420	Kansuinine B	Inhibitor	≥99.0%	Unkown
HY-128423AS	Tylvalosin-d9		/	Unkown
HY-131668	9-POHSA		/	Unkown
HY-131934	9-OAHSA		≥99.0%	Unkown
HY-134000	Emodic acid	Inhibitor	/	Unkown
HY-134371	IL-17 modulator 2	Modulator	/	Unkown
HY-13559A	Atiprimod dimaleate		/	Unkown
HY-143422	MALT1-IN-3	Inhibitor	/	Unkown
HY-143422A	(R)-MALT1-IN-3	Inhibitor	/	Unkown
HY-146419	Anti-inflammatory agent 20	Inhibitor	/	Unkown
HY-146483	Anti-Aβ agent 1A	Inhibitor	/	Unkown
HY-146547	Anti-inflammatory agent 17	Inhibitor	/	Unkown
HY-146561	S-HP210	Modulator	98.12%	Unkown
HY-148238	GNE-2256	Inhibitor	/	Unkown
HY-149333	BO-1	Inhibitor	/	Unkown
HY-149391	PROTAC BTK Degrader-6	Degrader	/	Unkown
HY-149485	JNK2-IN-1	Inhibitor	/	Unkown
HY-149816	Anti-inflammatory agent 41	Inhibitor	/	Unkown
HY-149940	SIMR3030	Inhibitor	/	Unkown
HY-150740	ODN 21595	Inhibitor	/	Unkown
HY-150740A	ODN 21595 sodium	Inhibitor	/	Unkown
HY-152213	BET-IN-13	Inhibitor	/	Unkown
HY-152251	CB2R/FAAH modulator-1		/	Unkown
HY-152957	STING agonist-24	Agonist	/	Unkown
HY-152958	STING agonist-25	Agonist	/	Unkown
HY-152961	STING agonist-28	Agonist	/	Unkown
HY-153330	TNF-α-IN-10	Inhibitor	/	Unkown
HY-155027	DPP-4-IN-8	Inhibitor	/	Unkown
HY-15509	Semapimod	Inhibitor	/	Unkown
HY-155160	COX-2/15-LOX-IN-3	Inhibitor	/	Unkown
HY-155161	COX-2/15-LOX-IN-4	Inhibitor	/	Unkown
HY-155199	PDE1-IN-5	Inhibitor	/	Unkown
HY-155243	12R-LOX-IN-1	Inhibitor	/	Unkown
HY-155405	Anti-inflammatory agent 64	Inhibitor	/	Unkown
HY-155753	Anti-inflammatory agent 50	Inhibitor	/	Unkown
HY-155820	Anti-inflammatory agent 54	Inhibitor	/	Unkown
HY-155821	Anti-inflammatory agent 55	Inhibitor	/	Unkown
HY-156297	β5i-IN-1	Inhibitor	/	Unkown
HY-157546	VEGFR-2-IN-40	Inhibitor	/	Unkown
HY-157809	Anti-inflammatory agent 74	Inhibitor	/	Unkown
HY-157992	LM-021	Inhibitor	/	Unkown
HY-158434	IRAK1-IN-1	Inhibitor	/	Unkown
HY-159146	PPARα agonist 4		/	Unkown
HY-159516	Sabialimon P	Inhibitor	/	Unkown
HY-160026	IL-17 modulator 8	Modulator	/	Unkown
HY-160028	IL-17 modulator 9	Modulator	/	Unkown
HY-160052	IL-6 aptamer sodium	Chemical	/	Unkown
HY-160231	ssRNA42 sodium	Activator	/	Unkown
HY-161240	MAO-B-IN-30	Inhibitor	98.53%	Unkown
HY-161396	Anti-inflammatory agent 76	Inhibitor	/	Unkown
HY-161620	DW18134	Inhibitor	/	Unkown
HY-161833	HSP90-IN-31	Inhibitor	/	Unkown
HY-161936	Z21115	Inhibitor	/	Unkown
HY-162122	PPARα/γ agonist 3	Agonist	/	Unkown
HY-162316	NF-κB-IN-15	Inhibitor	/	Unkown
HY-162622	BET-IN-26	Inhibitor	/	Unkown
HY-162641	AF-45	Inhibitor	/	Unkown
HY-162681	eeAChE-IN-3	Inhibitor	/	Unkown
HY-162797	PDE4-IN-18	Inhibitor	/	Unkown
HY-162963	PPARδ agonist 11	Agonist	/	Unkown
HY-163458	Anti-inflammatory agent 77	Inhibitor	/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-163748	GSK-3β inhibitor 17	Inhibitor	/	Unkown
HY-163755	GPER activator 1		/	Unkown
HY-163777	Talaroterphenyl A	Inhibitor	/	Unkown
HY-163848	Anti-inflammatory agent 90		/	Unkown
HY-163998	TLR4-IN-1		/	Unkown
HY-168010	RC529-MDP	Activator	/	Unkown
HY-168084	IL-17-IN-1	Inhibitor	/	Unkown
HY-A0031S	Bazedoxifene-d4	Modulator	/	Unkown
HY-A0031S2	Bazedoxifene-d4 acetate		/	Unkown
HY-B0141S4	Estradiol-13C6	Agonist	/	Unkown
HY-B0141S5	Estradiol-13C2	Agonist	/	Unkown
HY-B0141S6	Estradiol-d2-1	Agonist	/	Unkown
HY-B0260S	Methylprednisolone-d3		/	Unkown
HY-B0260S2	Methylprednisolone-d4		/	Unkown
HY-B0260S4	Methylprednisolone-d2		/	Unkown
HY-B0667S1	Balsalazide-d4	Inhibitor	/	Unkown
HY-N0976	1,11b-Dihydro-11b-hydroxymedicarpin		/	Unkown
HY-N11768	4-Methoxylonchocarpin	Inhibitor	/	Unkown
HY-N12042	Taxamairin B	Inhibitor	/	Unkown
HY-N12743	Farobin A	Inhibitor	/	Unkown
HY-N13114	8-Gingerdione		/	Unkown
HY-N2007S	Veratric acid-d6	Inhibitor	/	Unkown
HY-N3380	Linderaspirone A	Inhibitor	/	Unkown
HY-N3421	Koaburaside	Inhibitor	/	Unkown
HY-N3552	Catalposide	Inhibitor	≥98.0%	Unkown
HY-N4061	Hedycoronen A	Inhibitor	/	Unkown
HY-N7630	Rehmapicrogenin	Inhibitor	/	Unkown
HY-N8107	Matairesinol monoglucoside		/	Unkown
HY-N8936	Narchinol B		/	Unkown
HY-N9891	12-Dehydrogingerdione	Inhibitor	/	Unkown
HY-P10350	PapRIV	Agonist	/	Unkown
HY-P10710	BMP-4	Inhibitor	/	Unkown
HY-P1117A	MMK1 TFA		/	Unkown
HY-P5836	Citrullinated LL-37 1cit	Inhibitor	/	Unkown
HY-P5837	Citrullinated LL-37 2cit	Inhibitor	/	Unkown
HY-RS06774	IL6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06775	Il6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06776	Il6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06777	IL6R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06778	IL6ST Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-U00460B	3,6-DMAD dihydrochloride	Inhibitor	/	Unkown
HY-110133A	JTE-607 free base	Inhibitor	/	Unkown
HY-113545	9(R)-HODE		/	Unkown
HY-118312	CAY10657	Inhibitor	/	Unkown
HY-123625	R-348 choline	Inhibitor	/	Unkown
HY-124613	Pyrazinib	Inhibitor	/	Unkown
HY-146066A	(R)-α7 nAchR-JAK2-STAT3 agonist 1		/	Unkown
HY-167939	(R)-Bambuterol		/	Unkown
HY-N13202	Black Currant Extract		/	Unkown
HY-N9541	Chaetoglobosin Vb		/	Unkown
HY-W505984	TPNA10168	Activator	/	Unkown
HY-W923189	Neral	Inhibitor	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990008	Atrosab		96.93%	Unkown
HY-P99287	Elsilimomab	Inhibitor	95.00%	Unkown
HY-P99336	Enlimomab	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il6	NCBI	NCBI:3569
Macaca fascicularis	Il6	NCBI	NCBI:102138971
Rattus norvegicus	Il6	NCBI	NCBI:24498
Macaca mulatta	Il6	NCBI	NCBI:705819

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