Il6 - interleukin 6 Gene

Rattus norvegicus

Also known as ILg6; Ifnb2

Gene ID: 24498 | Gene type: protein coding

About Il6

Primary_assembly 4: 5,213,394-5,219,178 reverse strand.mRatBN7.2:CM026977.1

This gene has 3 transcripts (splice variants), 162 orthologues and is associated with 288 phenotypes. Biased expression in Spleen (RPKM 22.5) and Thymus (RPKM 3.4).

Summary

Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cell communication; and response to peptide hormone. Located in cytoplasm and extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; fatty liver disease; hypertension (multiple); and impotence. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); iron deficiency anemia; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6). [provided by Alliance of Genome Resources, Apr 2022]

Il6 Products(1)

mRNA	Protein	Name
NM_012589.2	NP_036721.1	interleukin-6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	16413512	RGD
enables interleukin-6 receptor binding	IDA IDA: Inferred from direct assay	12604335	RGD
enables signaling receptor binding	IDA IDA: Inferred from direct assay	1620288	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone remodeling	IEP IEP: Inferred from expression pattern	16193234	RGD
involved in cell redox homeostasis	IMP IMP: Inferred from mutant phenotype	7538937	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	8625883	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	2121800	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	10499497	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	12884291	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	2121800	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	2789217	RGD
involved in cellular response to nutrient levels	IEP IEP: Inferred from expression pattern	23079940	RGD
involved in cellular response to prolactin	IEP IEP: Inferred from expression pattern	10499497	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	2121800	RGD
involved in interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	29702085	RGD
involved in lymphocyte costimulation	IEP IEP: Inferred from expression pattern	22417871	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9645688	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	19061939	RGD
involved in negative regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	16308834	RGD
involved in negative regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	27108485	RGD
involved in negative regulation of muscle organ development	IDA IDA: Inferred from direct assay	19057004	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	19061939	RGD
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	15845578	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	15828022	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19061939	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19057004	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	7538937	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	9881636	RGD
involved in positive regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	15845578	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	20227492	RGD
involved in positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	12015387	RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	15659221	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	29702085	RGD
involved in positive regulation of transmission of nerve impulse	IDA IDA: Inferred from direct assay	19258490	RGD
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	15845578	RGD
involved in regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	12667648	RGD
involved in response to Gram-positive bacterium	IEP IEP: Inferred from expression pattern	20501441	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	19344884	RGD
involved in response to auditory stimulus	IEP IEP: Inferred from expression pattern	16429448	RGD
involved in response to bacterium	IEP IEP: Inferred from expression pattern	19374258	RGD
involved in response to caffeine	IEP IEP: Inferred from expression pattern	15845578	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	15845578	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	19395591	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	19410369	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	31116255	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	19373130	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19410080	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	11834488	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	19374947	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19399939	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19413671	RGD
involved in response to yeast	IEP IEP: Inferred from expression pattern	19375719	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19406831	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il6 Protein Structure

IL6

0
100
211 a.a.

Protein Preferred Names

Protein Names

interleukin-6

IL-6	Interleukin 6 (interferon, beta 2)

Recombinant Il6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7103A	IL-6 Protein, Rat (HEK293)	P20607 (F25-T211)	≥95%

Related Agents

Approval

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0260	Methylprednisolone		99.75%	Yes
HY-A0036	Bazedoxifene acetate	Modulator	99.98%	Yes
HY-A0031	Bazedoxifene	Modulator	99.06%	Yes
HY-B1402	Hydrocortisone hemisuccinate	Inhibitor	99.83%	Unkown
HY-B1350A	Fusidic acid sodium salt	Inhibitor	99.64%	Yes
HY-B0367	Lornoxicam		99.36%	Unkown
HY-B1402B	Hydrocortisone hemisuccinate sodium	Inhibitor	99.66%	Unkown
HY-B0446	Naphazoline hydrochloride		98.12%	Unkown
HY-B0667	Balsalazide	Inhibitor	99.34%	Yes
HY-B0513	Methylthiouracil	Inhibitor	≥98.0%	Unkown
HY-111326A	Naphazoline nitrate		≥98.0%	Unkown
HY-B0667A	Balsalazide sodium hydrate	Inhibitor	99.61%	Yes
HY-A0031A	Bazedoxifene hydrochloride	Modulator	/	Unkown
HY-111326	Naphazoline		/	Unkown
HY-B1402A	Hydrocortisone hemisuccinate hydrate	Inhibitor	/	Unkown
HY-B1402R	Hydrocortisone hemisuccinate (Standard)		/	Unkown
HY-108244	Balsalazide disodium	Inhibitor	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9917	Tocilizumab	Antagonist	99.67%	Unkown
HY-P9956	Siltuximab		≥99.0%	Unkown
HY-P99165	Teprotumumab	Inhibitor	99.46%	Unkown
HY-P99111	Golimumab		99.71%	Unkown
HY-P9916	Sarilumab	Inhibitor	98.37%	Unkown
HY-P99112	Satralizumab	Inhibitor	99.82%	Unkown

Clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114360AS1	Taurohyodeoxycholic acid-d4 sodium	Inhibitor	/	Phase 4
HY-11109	Resatorvid	Inhibitor	99.95%	Phase 3
HY-146244	Agatolimod	Agonist	/	Phase 3
HY-145564	Emprumapimod	Inhibitor	99.04%	Phase 3
HY-13740	Resiquimod		99.95%	Phase 2
HY-113066A	Guanosine 5'-diphosphate disodium salt	Activator	≥99.0%	Phase 2
HY-110133	JTE-607	Inhibitor	99.27%	Phase 2
HY-135317	Emavusertib		99.96%	Phase 2
HY-147041	Selvigaltin	Inhibitor	98.87%	Phase 2
HY-15509A	Semapimod tetrahydrochloride	Inhibitor	98.43%	Phase 2
HY-108039	Bezisterim	Inhibitor	≥95.0%	Phase 2
HY-N9965	2'-Fucosyllactose	Inhibitor	99.95%	Phase 2
HY-113066C	Guanosine 5'-diphosphate (sodium), 96% (HPLC)	Activator	99.88%	Phase 2
HY-113066	Guanosine 5'-diphosphate	Activator	/	Phase 2
HY-135317B	Emavusertib hydrochloride		/	Phase 2
HY-107390	AX-024	Inhibitor	99.29%	Phase 1
HY-107390A	AX-024 hydrochloride	Inhibitor	99.75%	Phase 1
HY-P3412	MMI-0100		98.83%	Phase 1

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99316	Sirukumab	Inhibitor	95.00%	Phase 3
HY-P99210	Olokizumab	Inhibitor	95.85%	Phase 3
HY-P99252	Itolizumab		≥99.0%	Phase 3
HY-P99505	Ziltivekimab	Inhibitor	99.75%	Phase 3
HY-P990012	Vamikibart	Inhibitor	≥99.0%	Phase 3
HY-P99012	Clazakizumab	Inhibitor	/	Phase 3
HY-P99702	Levilimab	Inhibitor	/	Phase 3
HY-P99385	Vobarilizumab	Inhibitor	97.36%	Phase 2

Pre-clinical Phase

Bioactive Molecules (275)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-102084	LMT-28	Inhibitor	98.93%	Unkown
HY-N0560	Oroxylin A		99.87%	Unkown
HY-W007376	Indole-3-carboxaldehyde		99.96%	Unkown
HY-141537	ABR-238901	Inhibitor	98.71%	Unkown
HY-15614	SC144		99.48%	Unkown
HY-N0029	Forsythoside B		99.99%	Unkown
HY-100339	GSK583	Inhibitor	99.93%	Unkown
HY-W251428	Phosphatidylglycerols (egg) sodium salt		99.92%	Unkown
HY-N0633	Muscone	Inhibitor	≥98.0%	Unkown
HY-N0236	Corylin	Inhibitor	99.97%	Unkown
HY-110126	AR-C118925XX	Antagonist	≥99.0%	Unkown
HY-N0405	Orientin	Inhibitor	99.73%	Unkown
HY-19744	T6167923	Inhibitor	99.40%	Unkown
HY-N0619	Mulberroside A	Inhibitor	99.86%	Unkown
HY-114869	DPQ	Inhibitor	≥99.0%	Unkown
HY-N0936	Coixol	Inhibitor	99.58%	Unkown
HY-100544	FLLL32		99.78%	Unkown
HY-N1949	Homoplantaginin	Inhibitor	99.90%	Unkown
HY-B0141S1	Estradiol-d4	Agonist	99.55%	Unkown
HY-150738	ODN 2088	Antagonist	90.41%	Unkown
HY-P3042	Chymostatin	Inhibitor	≥99.0%	Unkown
HY-150738C	ODN 2088 sodium	Antagonist	93.63%	Unkown
HY-19999A	PF-CBP1 hydrochloride	Inhibitor	99.96%	Unkown
HY-101448	TMI-1		99.59%	Unkown
HY-N0569	Madecassic acid	Inhibitor	99.81%	Unkown
HY-N2007	Veratric acid	Inhibitor	99.99%	Unkown
HY-N0604	Ginsenoside Rh1	Inhibitor	≥98.0%	Unkown
HY-N0710	alpha-Cyperone		99.12%	Unkown
HY-114360A	Taurohyodeoxycholic acid sodium	Inhibitor	99.60%	Unkown
HY-124750	NecroX-7	Inhibitor	99.69%	Unkown
HY-Y0148	10-Hydroxydecanoic acid	Inhibitor	98.77%	Unkown
HY-12875	BQU57	Inhibitor	99.45%	Unkown
HY-128754	Monoolein	Inhibitor	99.91%	Unkown
HY-15614A	SC144 hydrochloride		99.34%	Unkown
HY-N0314	Pectolinarin		99.89%	Unkown
HY-W013579	(S)-(+)-Carvone		99.26%	Unkown
HY-113330	12S-HHT	Agonist	≥99.0%	Unkown
HY-N0897	Corylifol A	Inhibitor	99.90%	Unkown
HY-128598	MD2-TLR4-IN-1	Inhibitor	99.62%	Unkown
HY-101259	BMS-195614		99.5%	Unkown
HY-113402A	Gamma-glutamylcysteine TFA		95.20%	Unkown
HY-150538	STAT3-IN-12		99.92%	Unkown
HY-152956	STING agonist-23	Agonist	99.16%	Unkown
HY-153190	W1131		99.25%	Unkown
HY-N7674	Angoline	Inhibitor	99.67%	Unkown
HY-P10284	S7	Antagonist	99.12%	Unkown
HY-W082785A	L6H21		99.46%	Unkown
HY-N1356	Reticuline	Inhibitor	98.91%	Unkown
HY-N2086	Ethyl palmitate	Inhibitor	99.05%	Unkown
HY-N6246	Asperulosidic Acid	Inhibitor	99.72%	Unkown
HY-111346	1-Linoleoyl Glycerol	Inhibitor	≥98.0%	Unkown
HY-128731	5-Methoxy-DL-tryptophan	Inhibitor	99.32%	Unkown
HY-N8146	Bruceantinol	Inhibitor	98.89%	Unkown
HY-146066	α7 nAchR-JAK2-STAT3 agonist 1		99.54%	Unkown
HY-B0260R	Methylprednisolone (Standard)		99.67%	Unkown
HY-N2572	Nepetin		99.51%	Unkown
HY-N4288	4-Methylesculetin	Inhibitor	98.21%	Unkown
HY-W041489	Chelidonic acid	Inhibitor	99.91%	Unkown
HY-B0141S	Estradiol-d3	Agonist	98.60%	Unkown
HY-113953	Z-Asp-CH2-DCB	Inhibitor	99.64%	Unkown
HY-121410	Narasin		≥98.0%	Unkown
HY-145846	iNOs-IN-1	Inhibitor	99.83%	Unkown
HY-153254	BMS905	Inhibitor	99.59%	Unkown
HY-23119	Sodium thiocyanate, GR, 99%		99.2%	Unkown
HY-112338	C188	Inhibitor	≥97.0%	Unkown
HY-14562	TBPB		99.74%	Unkown
HY-N7652	Terminolic acid	Inhibitor	99.63%	Unkown
HY-U00460	3,6-DMAD hydrochloride	Inhibitor	99.50%	Unkown
HY-126421	Kansuinine A	Inhibitor	99.81%	Unkown
HY-148706	STAT3-IN-17	Inhibitor	≥98.0%	Unkown
HY-150745A	ODN 24987 sodium		92.42%	Unkown
HY-155335	FPR2 agonist 3	Agonist	99.39%	Unkown
HY-B0141S2	Estradiol-d5	Agonist	99.88%	Unkown
HY-N7275	Di-O-methyldemethoxycurcumin	Inhibitor	97.64%	Unkown
HY-N9315	Episappanol	Inhibitor	98.57%	Unkown
HY-131688	2-Chlorohexadecanoic acid	Inhibitor	99.88%	Unkown
HY-150744A	ODN 24888 sodium		93.10%	Unkown
HY-N0857	Deoxyandrographolide	Activator	99.87%	Unkown
HY-134353B	ADP-β-S trilithium	Activator	85.30%	Unkown
HY-171034	PQA-18	Inhibitor	99.62%	Unkown
HY-129113	α-Chaconine	Inhibitor	99.04%	Unkown
HY-N1940	β-Anhydroicaritin	Inhibitor	99.69%	Unkown
HY-P0064	Palmitoyl Tetrapeptide-3	Inhibitor	99.20%	Unkown
HY-P0317	Interleukin (IL)-6 Receptor		98.03%	Unkown
HY-W1000105	Geranial	Inhibitor	99.51%	Unkown
HY-153190A	W1131 TFA		99.27%	Unkown
HY-W026772	Fluorene		99.35%	Unkown
HY-13740S	Resiquimod-d5		99.84%	Unkown
HY-156025	HCAR2 agonist 1	Agonist	99.11%	Unkown
HY-B0141S3	Estradiol-d2	Agonist	99.44%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-146564A	HP210	Modulator	98.96%	Unkown
HY-152959	STING agonist-26	Agonist	99.56%	Unkown
HY-169402	PDE1-IN-9	Inhibitor	/	Unkown
HY-B0260S3	Methylprednisolone-d7		99.73%	Unkown
HY-N6927	Isoforskolin	Inhibitor	≥98.0%	Unkown
HY-N7064	Iminostilbene	Inhibitor	99.34%	Unkown
HY-P1117	MMK1		99.22%	Unkown
HY-113066S2	Guanosine 5'-diphosphate-d13 dilithium	Activator	/	Unkown
HY-115910A	Y13g dihydrochloride	Inhibitor	99.89%	Unkown
HY-146564	R-HP210		98.21%	Unkown
HY-147506	NOD2 antagonist 1	Antagonist	99.57%	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-150745	ODN 24987	Inhibitor	/	Unkown
HY-151876	Glucocorticoid receptor modulator 1		99.79%	Unkown
HY-153579	Anti-inflammatory agent 42	Inhibitor	≥98.0%	Unkown
HY-169004	CBT-295	Inhibitor	99.34%	Unkown
HY-N0569R	Madecassic acid (Standard)	Inhibitor	/	Unkown
HY-N0619A	cis-Mulberroside A	Inhibitor	≥96.0%	Unkown
HY-N0811	Anemarsaponin B	Inhibitor	/	Unkown
HY-N11768	4-Methoxylonchocarpin	Inhibitor	≥98.0%	Unkown
HY-N7674A	Angoline hydrochloride	Inhibitor	/	Unkown
HY-N8413	Chlojaponilactone B	Inhibitor	≥98.0%	Unkown
HY-D1056C1	Lipopolysaccharides, from S. enterica serotype enteritidis	Activator	/	Unkown
HY-W923189	Neral	Inhibitor	/	Unkown
HY-172451	MC4762	Inhibitor	/	Unkown
HY-103438	BIBU1361	Inhibitor	/	Unkown
HY-103438A	BIBU1361 dihydrochloride		/	Unkown
HY-111077	INCB16562	Inhibitor	/	Unkown
HY-111164	CBS-3595	Inhibitor	/	Unkown
HY-113066B	Guanosine 5'-diphosphate ditromethamine	Activator	/	Unkown
HY-113066S1	Guanosine 5'-diphosphate-13C10 dilithium	Activator	/	Unkown
HY-113066S3	Guanosine 5'-diphosphate-13C10,15N5 dilithium	Activator	/	Unkown
HY-114592	M199		/	Unkown
HY-115910	Y13g	Inhibitor	/	Unkown
HY-115913	PDE4-IN-6	Inhibitor	/	Unkown
HY-115976	COX-2-IN-10	Inhibitor	/	Unkown
HY-116227	(2S,3R)-LP99	Inhibitor	/	Unkown
HY-117511	HJC0123		/	Unkown
HY-122767	Romurtide	Activator	/	Unkown
HY-123522	PAT-048	Inhibitor	/	Unkown
HY-126420	Kansuinine B	Inhibitor	≥99.0%	Unkown
HY-128423AS	Tylvalosin-d9		/	Unkown
HY-131668	9-POHSA		/	Unkown
HY-131934	9-OAHSA		≥99.0%	Unkown
HY-134000	Emodic acid	Inhibitor	/	Unkown
HY-134371	IL-17 modulator 2	Modulator	/	Unkown
HY-13559A	Atiprimod dimaleate		/	Unkown
HY-143422	MALT1-IN-3	Inhibitor	/	Unkown
HY-143422A	(R)-MALT1-IN-3	Inhibitor	/	Unkown
HY-146066A	(R)-α7 nAchR-JAK2-STAT3 agonist 1	Agonist	98.45%	Unkown
HY-146419	Anti-inflammatory agent 20	Inhibitor	/	Unkown
HY-146483	Anti-Aβ agent 1A	Inhibitor	/	Unkown
HY-146547	Anti-inflammatory agent 17	Inhibitor	/	Unkown
HY-146561	S-HP210	Modulator	98.12%	Unkown
HY-148238	GNE-2256	Inhibitor	/	Unkown
HY-149333	BO-1	Inhibitor	/	Unkown
HY-149391	PROTAC BTK Degrader-6	Degrader	/	Unkown
HY-149485	JNK2-IN-1	Inhibitor	/	Unkown
HY-149816	Anti-inflammatory agent 41	Inhibitor	/	Unkown
HY-149940	SIMR3030	Inhibitor	/	Unkown
HY-150740	ODN 21595	Inhibitor	/	Unkown
HY-150740A	ODN 21595 sodium	Inhibitor	/	Unkown
HY-152213	BET-IN-13	Inhibitor	/	Unkown
HY-152251	CB2R/FAAH modulator-1		/	Unkown
HY-152957	STING agonist-24	Agonist	/	Unkown
HY-152958	STING agonist-25	Agonist	/	Unkown
HY-152961	STING agonist-28	Agonist	/	Unkown
HY-153330	TNF-α-IN-10	Inhibitor	/	Unkown
HY-155027	DPP-4-IN-8	Inhibitor	/	Unkown
HY-15509	Semapimod	Inhibitor	/	Unkown
HY-155160	COX-2/15-LOX-IN-3	Inhibitor	/	Unkown
HY-155161	COX-2/15-LOX-IN-4	Inhibitor	/	Unkown
HY-155199	PDE1-IN-5	Inhibitor	/	Unkown
HY-155243	12R-LOX-IN-1	Inhibitor	/	Unkown
HY-155405	Anti-inflammatory agent 64	Inhibitor	/	Unkown
HY-155753	Anti-inflammatory agent 50	Inhibitor	/	Unkown
HY-155820	Anti-inflammatory agent 54	Inhibitor	/	Unkown
HY-155821	Anti-inflammatory agent 55	Inhibitor	/	Unkown
HY-156297	β5i-IN-1	Inhibitor	/	Unkown
HY-157546	VEGFR-2-IN-40	Inhibitor	/	Unkown
HY-157809	Anti-inflammatory agent 74	Inhibitor	/	Unkown
HY-157992	LM-021	Inhibitor	/	Unkown
HY-158434	IRAK1-IN-1	Inhibitor	/	Unkown
HY-159146	PPARα agonist 4		/	Unkown
HY-159516	Sabialimon P	Inhibitor	/	Unkown
HY-159891	Microtubule destabilizing agent-2		/	Unkown
HY-160026	IL-17 modulator 8	Modulator	/	Unkown
HY-160028	IL-17 modulator 9	Modulator	/	Unkown
HY-160052	IL-6 aptamer sodium	Chemical	/	Unkown
HY-160231	ssRNA42 sodium	Activator	/	Unkown
HY-161240	MAO-B-IN-30	Inhibitor	98.53%	Unkown
HY-161396	Anti-inflammatory agent 76	Inhibitor	/	Unkown
HY-161620	DW18134	Inhibitor	/	Unkown
HY-161833	HSP90-IN-31	Inhibitor	/	Unkown
HY-161936	Z21115	Inhibitor	/	Unkown
HY-162122	PPARα/γ agonist 3	Agonist	/	Unkown
HY-162316	NF-κB-IN-15	Inhibitor	/	Unkown
HY-162622	BET-IN-26	Inhibitor	/	Unkown
HY-162641	AF-45	Inhibitor	/	Unkown
HY-162681	eeAChE-IN-3	Inhibitor	/	Unkown
HY-162797	PDE4-IN-18	Inhibitor	/	Unkown
HY-162963	PPARδ agonist 11	Agonist	/	Unkown
HY-163458	Anti-inflammatory agent 77	Inhibitor	/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-163748	GSK-3β inhibitor 17	Inhibitor	/	Unkown
HY-163755	GPER activator 1		/	Unkown
HY-163777	Talaroterphenyl A	Inhibitor	/	Unkown
HY-163848	Anti-inflammatory agent 90	Inhibitor	/	Unkown
HY-163998	TLR4-IN-1		/	Unkown
HY-167939	(R)-Bambuterol		/	Unkown
HY-168084	IL-17-IN-1	Inhibitor	/	Unkown
HY-168340	COX-2/15-LOX-IN-6	Inhibitor	/	Unkown
HY-168466	Anti-neuroinflammation agent 2	Inhibitor	/	Unkown
HY-168482	NF-κB/MAPK-IN-2	Inhibitor	/	Unkown
HY-168709	Nrf2 activator 18	Activator	/	Unkown
HY-168734	CB2 receptor agonist 9	Agonist	/	Unkown
HY-168922	Keap1-Nrf2-IN-25	Inhibitor	/	Unkown
HY-168952	GHN105		/	Unkown
HY-169417	Euphjatrophane M	Inhibitor	/	Unkown
HY-169420	IL-6-IN-1	Inhibitor	/	Unkown
HY-170415	EGR-1-IN-3	Inhibitor	/	Unkown
HY-170492	sEH inhibitor-19		/	Unkown
HY-170495	HDAC6 degrader-5	Inhibitor	/	Unkown
HY-170621	STAT1/3-IN-1	Inhibitor	/	Unkown
HY-172111	EGFR-IN-144		/	Unkown
HY-172406	MAPK-IN-4		/	Unkown
HY-172409	CB1R antagonist 2		/	Unkown
HY-19606	Cytogenin	Inhibitor	/	Unkown
HY-A0031S	Bazedoxifene-d4	Modulator	/	Unkown
HY-A0031S2	Bazedoxifene-d4 acetate		/	Unkown
HY-B0141S4	Estradiol-13C6	Agonist	/	Unkown
HY-B0141S5	Estradiol-13C2	Agonist	/	Unkown
HY-B0141S6	Estradiol-d2-1	Agonist	/	Unkown
HY-B0260S	Methylprednisolone-d3		/	Unkown
HY-B0260S2	Methylprednisolone-d4		/	Unkown
HY-B0260S4	Methylprednisolone-d2		/	Unkown
HY-B0667S1	Balsalazide-d4	Inhibitor	/	Unkown
HY-N0604R	Ginsenoside Rh1 (Standard)	Inhibitor	/	Unkown
HY-N0976	1,11b-Dihydro-11b-hydroxymedicarpin		/	Unkown
HY-N12042	Taxamairin B	Inhibitor	/	Unkown
HY-N12743	Farobin A	Inhibitor	/	Unkown
HY-N13114	8-Gingerdione		/	Unkown
HY-N2007S	Veratric acid-d6	Inhibitor	/	Unkown
HY-N3380	Linderaspirone A	Inhibitor	/	Unkown
HY-N3421	Koaburaside	Inhibitor	/	Unkown
HY-N3552	Catalposide	Inhibitor	≥98.0%	Unkown
HY-N4061	Hedycoronen A	Inhibitor	/	Unkown
HY-N7630	Rehmapicrogenin	Inhibitor	/	Unkown
HY-N8107	Matairesinol monoglucoside	Inhibitor	/	Unkown
HY-N8936	Narchinol B		/	Unkown
HY-N9891	12-Dehydrogingerdione	Inhibitor	/	Unkown
HY-P10350	PapRIV	Agonist	/	Unkown
HY-P10710	BMP-4	Inhibitor	/	Unkown
HY-P10796	YARA peptide	Inhibitor	/	Unkown
HY-P10854	TAT-N15	Inhibitor	/	Unkown
HY-P1117A	MMK1 TFA		/	Unkown
HY-P5836	Citrullinated LL-37 1cit	Inhibitor	/	Unkown
HY-P5837	Citrullinated LL-37 2cit	Inhibitor	/	Unkown
HY-RS06774	IL6 Human Pre-designed siRNA Set A		/	Unkown
HY-RS06775	Il6 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS06776	Il6 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS06777	IL6R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06778	IL6ST Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-U00460B	3,6-DMAD dihydrochloride	Inhibitor	/	Unkown
HY-W424851	DPQ hydrochloride	Inhibitor	/	Unkown
HY-W995241	BPD	Inhibitor	/	Unkown
HY-101410A	SDMA (p-hydroxyazobenzene-p′-sulfonate)		/	Unkown
HY-107299	Trichilinin D		/	Unkown
HY-107338	Denotivir	Inhibitor	/	Unkown
HY-110133A	JTE-607 free base	Inhibitor	/	Unkown
HY-110151	Bengamide B	Inhibitor	/	Unkown
HY-113545	9(R)-HODE		/	Unkown
HY-118312	CAY10657	Inhibitor	/	Unkown
HY-123625	R-348 choline	Inhibitor	/	Unkown
HY-124613	Pyrazinib	Inhibitor	/	Unkown
HY-135317C	Emavusertib tosylate		/	Unkown
HY-135317D	Emavusertib mesylate		/	Unkown
HY-135317E	Emavusertib maleate		/	Unkown
HY-135317F	Emavusertib phosphate		/	Unkown
HY-168782	Resolvin D2 n-3 DPA	Inhibitor	/	Unkown
HY-N13202	Black Currant Extract		/	Unkown
HY-N15347	Talaromyketide B	Inhibitor	/	Unkown
HY-N9541	Chaetoglobosin Vb		/	Unkown
HY-W505984	TPNA10168	Activator	/	Unkown

Inhibitory Antibodies (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990008	Atrosab		98.00%	Unkown
HY-P99287	Elsilimomab	Inhibitor	98.44%	Unkown
HY-P990212	Anti-Mouse IL-6 Antibody (MP5-20F3)	Inhibitor	99.20%	Unkown
HY-P99336	Enlimomab	Inhibitor	95.00%	Unkown
HY-P990211	Anti-Mouse IL-6R Antibody (15A7)	Inhibitor	95.00%	Unkown
HY-P990662	Sapelizumab	Inhibitor	98.31%	Unkown
HY-P990937	Pacibekitug	Inhibitor	/	Unkown
HY-P991030	Tabirafusp alfa	Inhibitor	/	Unkown
HY-P990547	APX-007	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il6	NCBI	NCBI:3569
Macaca fascicularis	Il6	NCBI	NCBI:102138971
Mus musculus	Il6	NCBI	NCBI:16193
Macaca mulatta	Il6	NCBI	NCBI:705819

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