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S1

" in MedChemExpress (MCE) Product Catalog:

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125743

S-1 Methanandamide (S)-Methanandamide	Cannabinoid Receptor	Neurological Disease
S-1 Methanandamide ((S)-Methanandamide), an Anandamide analog, is a CB1 receptor ligand with a K_i of 173 nM. S-1 Methanandamide inhibits electrically-evoked twitch response in mouse vas deferens with an IC₅₀ value of 230 nM ^[1].

HY-P10283

S1H	GHSR STAT	Endocrinology
S1H, a mimetic of hGH, is a human growth hormone receptor (hGHR) antagonist. S1H inhibits the interaction of hGH with hGHR. S1H inhibits phosphorylation of STAT5 in cells co-treated with hGH ^[1].

HY-111827

S-1-Propenyl-L-cysteine 5 Publications Verification	Histamine Receptor	Cardiovascular Disease Others Metabolic Disease Inflammation/Immunology
S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model ^[1]. S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway . S-1-Propenyl-L-cysteine is orally active.

HY-12835

S1P1 agonist III	LPL Receptor	Inflammation/Immunology
S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3.

HY-40040

*(S)-1-Boc-3-methylpiperazine*	Biochemical Assay Reagents	Others
(S)-1-Boc-3-methylpiperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-40023

*(S)-1-Boc-3-hydroxypiperidine*	Biochemical Assay Reagents	Others
(S)-1-Boc-3-hydroxypiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-16441

Tegafur-gimeracil-oteracil potassium S-1; TS-1	Others	Cancer
Tegafur-gimeracil-oteracil potassium (TS-1) is an oral anticancer agent composed of Tegafur (HY-17400), Gimeracil (HY-17469), and Oteracil potassium (HY-17511) at a molar ratio of 1:0.4:1. TS-1 can be utilized in research on the peritoneal dissemination of gastric cancer ^[1].

HY-115566

S1PL-IN-1	LPL Receptor Smo	Inflammation/Immunology
S1PL-IN-31 (compound ) is an oral active sphingosine-1-phosphate (S1P) lyase inhibitor with the IC₅₀ of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC₅₀ of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis ^[1] .

HY-162008

S1g-10	HSP Bcl-2 Family	Cancer
S1g-10 is a Hsp70/Bim inhibitor, and shows antitumor activity in chronic myeloid leukemia cells ^[1].

HY-129115

S1QEL1.1	Reactive Oxygen Species Caspase	Others
S1QEL1.1 is a small molecule inhibitor that specifically inhibits the generation of superoxide and hydrogen peroxide at the IQ site during reverse electron transfer in mitochondrial respiratory chain complex I (Complex I), with an IC₅₀ of 0.07 μM. S1QEL1.1 can significantly reduce the activation of cysteine-aspartic protease (caspase) triggered by endoplasmic reticulum stress. S1QEL1.1 helps to decrease excessive proliferation of stem cells by inhibiting the Reactive Oxygen Species signaling pathway initiated by endoplasmic reticulum stress ^[1].

HY-40098

*(S)-1-Boc-3-aminopyrrolidine*	Biochemical Assay Reagents	Others
(S)-1-Boc-3-aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W016644

*(S)-1-Benzylpyrrolidin-3-ol*	Drug Intermediate	Cardiovascular Disease Others
(S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive agent Barnidipine hydrochloride (HY-107322) ^[1].

HY-18099A

S1RA hydrochloride 2 Publications Verification E-52862 hydrochloride	Sigma Receptor 5-HT Receptor	Neurological Disease
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a K_i value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (K_i >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC₅₀ value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization ^[1] .

HY-149803

S1R agonist 1	Sigma Receptor	Neurological Disease
S1R agonist 1 (Compound 6b) is a selective *S1R* agonist with K_is of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity ^[1].

HY-149803A

S1R agonist 1 hydrochloride	Sigma Receptor	Neurological Disease
S1R agonist 1 (Compound 6b) hydrochloride is a selective *S1R* agonist with K_is of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity ^[1].

HY-149804A

S1R agonist 2 hydrochloride	Sigma Receptor	Neurological Disease
S1R agonist 2 (Compound 8b) hydrochloride is a selective *S1R* agonist with K_is of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity ^[1].

HY-149804

S1R agonist 2	Sigma Receptor	Neurological Disease
S1R agonist 2 (Compound 8b) is a selective *S1R* agonist with K_is of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity ^[1].

HY-U00366

S1PR1-MO-1	LPL Receptor	Inflammation/Immunology
S1PR-MO-1 is the modulator of sphingosine-1-phosphate receptor, used for research of hyperproliferative, inflammatory diseases.

HY-126145

S1PR1 modulator 1	LPL Receptor	Inflammation/Immunology
S1PR1 modulator 1 is a selective *S1PR1* inhibitor, with a pIC₅₀ of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4 ^[1].

HY-W127836

*EDTA-(S)-1-(4-Aminoxyacetamidobenzyl)* (S)-1-(4-Aminoxyacetamidobenzyl)ethylenediaminetetraacetic acid	Biochemical Assay Reagents	Others
(S)-1-(4-Aminoxyacetamidobenzyl)ethylenediaminetetraacetic Acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-18099

S1RA 2 Publications Verification E-52862	Sigma Receptor 5-HT Receptor	Neurological Disease
S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with K_is of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT_2B receptor (K_i= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice ^[1] .

HY-149210

S1PR1 Radioligand 1	LPL Receptor	Others
S1PR1 Radioligand 1(compound 6 h) is a specific S1PR1 radioligand with IC₅₀ = 8.7 nM. S1PR1 Radioligand 1 has good brain uptake and can be used as a S1PR1-specific F-18 radiotracer for studying the function of S1PR1 in brain diseases ^[1].

HY-40102

*(S)-1-Boc-2-(aminomethyl)pyrrolidine*	Biochemical Assay Reagents	Others
(S)-1-Boc-2-(aminomethyl)pyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-148115

S1p receptor agonist 2	LPL Receptor	Inflammation/Immunology
S1p receptor agonist 2 (compound 1) is an agonist of S1P5 receptor, exhibits selectivity over the *S1P1* and/or S1P3 receptors. S1p receptor agonist 2 can be used for endogenous SIP signaling system research, and alleviating or preventing CNS disorders research, such as neurodegenerative disorders ^[1].

HY-104069

S1P1 agonist 1	LPL Receptor	Inflammation/Immunology
S1P1 Agonist 1 is a *S1P1* agonist with immunomodulatory activities.

HY-P10855

S1b3inL1	SARS-CoV	Infection
S1b3inL1 is a SARS-CoV-2 spike protein macrocyclic peptide inhibitor. S1b3inL1 can bind the conserved site of spike protein with high affinity and inhibit the infection of various SARS-CoV-2 variant strains. S1b3inL1 has antiviral activity ^[1].

HY-144126

S1P1 agonist 5	LPL Receptor	Inflammation/Immunology
S1P1 agonist 5 is a selective and orally active *S1P1* agonist. S1P1 agonist 5 inhibits the lymphocyte egress from the lymphoid tissue to the peripheral blood. S1P1 agonist 5 has the potential for the research of multiple sclerosis (MS) ^[1].

HY-148198

S1P5 receptor agonist-1	LPL Receptor	Inflammation/Immunology
S1P5 receptor agonist-1 (example 6) is a potent and selective agonist of S1P₅ receptor with an EC₅₀ value of 20 nM ^[1].

HY-108496

Sphingosine-1-phosphate 5+ Cited Publications S1P	Endogenous Metabolite LPL Receptor	Inflammation/Immunology Endocrinology Cancer
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors ^[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids . Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration .

HY-141845

S1P2 antagonist 1	LPL Receptor	Others
S1P2 antagonist 1 is an orally bioavailable *S1P2* antagonist against fibrotic diseases.

HY-W051093

*(S)-1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid*	Amino Acid Derivatives	Others
(S)-1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid is a proline derivative ^[1].

HY-129942

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate	ADC Linker	Cancer
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes ^[1].

HY-156565

S1P1 agonist 6	LPL Receptor	Inflammation/Immunology
S1P1 agonist 6 (Compound I) is a *S1P1* agonist that reduces autoimmune ability by blocking the transportation of lymphocytes. S1P1 agonist 6 can be used as an immunosuppressive agent in the study of various autoimmune diseases research ^[1].

HY-143864

S1PR1 agonist 1	LPL Receptor	Inflammation/Immunology
S1PR1 agonist 1 is a potent agonist of *S1PR1. Sphingosine-1*-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 1 has the potential for the research of autoimmune diseases (extracted from patent WO2021175223A1, compound 22) ^[1].

HY-143865

S1PR1 agonist 2	LPL Receptor	Inflammation/Immunology
S1PR1 agonist 2 is a potent agonist of *S1PR1. Sphingosine-1*-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 2 has the potential for the research of autoimmune diseases (extracted from patent WO2021175225A1, compound 1) ^[1].

HY-W127793

EDTA-p-Bromoacetamido benzyl (S)-1-(p-Bromoacetamidobenzyl)ethylenediaminetetraacetic acid	Biochemical Assay Reagents	Others
EDTA-p-Bromoacetamido benzyl ((S)-1-(p-Bromoacetamidobenzyl)ethylenediaminetetraacetic acid) is a compound of EDTA and phenylbromoacetamide that can be coupled to antibodies ^[1].

HY-156565A

S1P1 agonist 6 hemicalcium	LPL Receptor	Inflammation/Immunology
S1P1 agonist 6 hemicalcium (Compound I) is a *S1P1* agonist that reduces autoimmune ability by blocking the transportation of lymphocytes. S1P1 agonist 6 hemicalcium can be used as an immunosuppressive agent in the study of various autoimmune diseases research ^[1].

HY-117213

Ex26 S1P1-IN-Ex26	LPL Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P₁) antagonist (IC₅₀=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P₁ over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach ^[1].

HY-W063269

*(S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate*	Amino Acid Derivatives	Others
(S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate is a proline derivative ^[1].

HY-W585815S

*(S)-1-Chloro-3-(hexadecyloxy)propan-2-ol-d5*	Isotope-Labeled Compounds	Others
(S)-1-Chloro-3-(hexadecyloxy)propan-2-ol-d₅ is a deuterium labeled compound.

HY-101265

Icanbelimod S1p receptor agonist 1	LPL Receptor	Inflammation/Immunology
Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2.

HY-115831

SAR247799 S1P1 agonist 3	LPL Receptor	Cardiovascular Disease
SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC₅₀s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome ^[1] .

HY-W087444A

*(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol*	Bacterial Antibiotic	Infection
(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol is an active constituent of the aerial parts of Angelica sinensis. (S)-1-(4-Hydroxyphenyl)ethane-1,2-diol significantly inhibits the growth of Aeromonas hydrophila. Anticoagulative and antibiotic activities ^[1].

HY-40029

*(S)-1-Boc-3-aminopiperidine* (S)-(+)-3-Amino-1-boc-piperidine	Biochemical Assay Reagents	Others
(S)-1-Boc-3-aminopiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-144153S

S-(1,2-Dichlorovinyl)glutathione-13C2,15N	Isotope-Labeled Compounds	Others
S-(1,2-Dichlorovinyl)glutathione- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled S-(1,2-Dichlorovinyl)glutathione[1].

HY-RS12402

S1pr4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
S1pr4 Rat Pre-designed siRNA Set A contains three designed siRNAs for S1pr4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1pr4 Rat Pre-designed siRNA Set A S1pr4 Rat Pre-designed siRNA Set A

HY-RS12391

S1PR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LPL Receptor	Others
S1PR1 Human Pre-designed siRNA Set A contains three designed siRNAs for S1PR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1PR1 Human Pre-designed siRNA Set A S1PR1 Human Pre-designed siRNA Set A

HY-RS12405

S1pr5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LPL Receptor	Others
S1pr5 Rat Pre-designed siRNA Set A contains three designed siRNAs for S1pr5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1pr5 Rat Pre-designed siRNA Set A S1pr5 Rat Pre-designed siRNA Set A

HY-RS12399

S1pr3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
S1pr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for S1pr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1pr3 Rat Pre-designed siRNA Set A S1pr3 Rat Pre-designed siRNA Set A

HY-RS12395

S1pr2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) LPL Receptor	Others
S1pr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

S1pr2 Mouse Pre-designed siRNA Set A S1pr2 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111827

S-1-Propenyl-L-cysteine 5 Publications Verification	Cardiovascular Disease Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Allium sativum Linn. Plants Disease Research Fields	Histamine Receptor
S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model ^[1]. S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway . S-1-Propenyl-L-cysteine is orally active.

HY-108496

Sphingosine-1-phosphate 5+ Cited Publications S1P	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist of S1P_1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca ²⁺ as an extracellular ligand for G protein-coupled receptors ^[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids . Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration .

HY-116290

Zaragozic acid A 1 Publications Verification Squalestatin S1	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Farnesyl Transferase Fungal Endogenous Metabolite
Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase ^[1].

HY-N12625A

(S)-(-)-O-Demethylbuchenavianine	Structural Classification Alkaloids Flavonoids Flavones Other Alkaloids Buchenavia macrophylla Spruce ex Eichler Combretaceae Source classification Plants	CDK
(S)-(-)-O-Demethylbuchenavianine (Compound (S)-(−)-1) is a flavonoidal alkaloids. (S)-(-)-O-Demethylbuchenavianine is a potent CDK inhibitor, with IC₅₀ values of 0.03 and 0.05 μM for CDK1 and CDK5, respectively ^[1].

HY-W087444A

*(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol*	Infection Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Bacterial Antibiotic
(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol is an active constituent of the aerial parts of Angelica sinensis. (S)-1-(4-Hydroxyphenyl)ethane-1,2-diol significantly inhibits the growth of Aeromonas hydrophila. Anticoagulative and antibiotic activities ^[1].

HY-N9022

*(S)-1-(4-Hydroxy-2,2-dimethylchroman-6-yl)ethanone*	Natural Products Source classification Plants Compositae Tephrosia purpurea (L.) Pers.	Others
(S)-1-(4-Hydroxy-2,2-dimethylchroman-6-yl)ethanone is an enantiopure chiral alcohol. Stereoselective reduction of prochiral ketones is studied by using both cell cultures and wild tissues of various endemic plant species ^[1].

HY-W011309A

1-O-Hexadecyl-sn-glycerol (S)-1-O-HDG; (S)-HXDG	Structural Classification Natural Products Marine natural products Source classification Sponge	PPAR
1-O-Hexadecyl-sn-glycerol [(S)-HXDG] is an alkyl glycerol monoether derived from T. aurantia ^[1].

HY-N6680R

Virginiamycin S1 (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antibacterial Disease Research	Bacterial Antibiotic
Virginiamycin S1 (Standard) is the analytical standard of Virginiamycin S1. This product is intended for research and analytical applications. Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections ^[1] .

HY-N6680

Virginiamycin S1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Bacterial Antibiotic
Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections ^[1][2].

HY-N3923

Ganoderic acid S1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
Ganoderic acid S1 (compound 4) is a natural product that can be found in ganoderma lucidum ^[1].

HY-126419

Kobophenol A	Infection Classification of Application Fields Source classification Cyperaceae Phenols Polyphenols Plants Disease Research Fields Carex kobomugi Ohwi	SARS-CoV PKC
Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC₅₀ of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC₅₀ of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC₅₀ of 52 µM ^[1] .

HY-79334

*(S)-(+)-1,2-Propanediol*	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(S)-(+)-1,2-Propanediol is an endogenous metabolite.

HY-111826

*γ-Glutamyl-S-1-propenyl cysteine* 1 Publications Verification	Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Allium sativum Linn. Plants Disease Research Fields	Others
γ-Glutamyl-S-1-propenyl cysteine is a compound isolated from garlic ^[1].

HY-111825A

(R)-1-PeCSO Isoalliin; trans-(+)-S-1-Propenyl-L-cysteine sulfoxide	Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Allium cepa L. Plants Disease Research Fields	Endogenous Metabolite
(R)-1-PeCSO (trans-(+)-S-1-Propenyl-L-cysteine sulfoxide) is the most abundant flavor precursor in onions ^[1].

HY-N3859

Erythro-1-phenylpropane-1,2-diol (1R,2S)-1-Phenyl-1,2-propanediol	Structural Classification Natural Products Microorganisms Source classification	Others
Erythro-1-phenylpropane-1,2-diol? ((1R,2S)-1-Phenyl-1,2-propanediol) is a secondary alcohol ^[1].

HY-W040240

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite.

HY-N15208

(3S,5S)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-3,5-heptanediol	Structural Classification Monophenols Source classification Phenols Plants Alpinia oxyphylla Miq. Zingiberaceae	Endogenous Metabolite
(3S,5S)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-3,5-heptanediol is a heptane compound that can be isolated from Alpinia oxyphylla ^[1].

HY-79334R

*(S)-(+)-1,2-Propanediol (Standard)*	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite

HY-W040240R

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides	Endogenous Metabolite

HY-119219

Detoxin C1	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Detoxin C1 is an active principle of detoxin complex. Detoxin complex is an antagonist of Blasticidin S .

HY-B1899A

Taurodeoxycholic acid sodium hydrate 5 Publications Verification Sodium taurodeoxycholate monohydrate	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Taurodeoxycholic acid sodium hydrate activates the *S1PR2* pathway in addition to the TGR5 pathway ^[1].

HY-N1150

Thymidine 10+ Cited Publications DThyd; NSC 21548	Structural Classification Natural Products Immune System Disorder Microorganisms Classification of Application Fields Source classification Disease markers Other Diseases Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus
Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication ^[1] .

HY-W089835R

Sodium taurodeoxycholate hydrate (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite
Sodium taurodeoxycholate hydrate (Standard) is the analytical standard of Sodium taurodeoxycholate hydrate. This product is intended for research and analytical applications. Sodium taurodeoxycholate hydrate, a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Sodium taurodeoxycholate hydrate activates the S1PR2 pathway in addition to the TGR5 pathway ^[1].

HY-125098

Illudin S 1 Publications Verification	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	DNA Alkylator/Crosslinker Apoptosis
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells ^[1] .

HY-N1150R

Thymidine (Standard)	Structural Classification Natural Products Immune System Disorder Microorganisms Source classification Disease markers Endogenous metabolite	DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus
Thymidine (Standard) is the analytical standard of Thymidine. This product is intended for research and analytical applications. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication ^[1] .

HY-16637D

Folic acid disodium Maximum Cited Publications 13 Publications Verification Vitamin B9 disodium; Vitamin M disodium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite DNA/RNA Synthesis
Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 ⁵ g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .

Cat. No.	Product Name	Chemical Structure

HY-W585815S

*(S)-1-Chloro-3-(hexadecyloxy)propan-2-ol-d5*
(S)-1-Chloro-3-(hexadecyloxy)propan-2-ol-d₅ is a deuterium labeled compound.

HY-108496S

Sphingosine-1-phosphate-d7

Sphingosine-1-phosphate-d₇ is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

HY-144153S

S-(1,2-Dichlorovinyl)glutathione-13C2,15N
S-(1,2-Dichlorovinyl)glutathione- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled S-(1,2-Dichlorovinyl)glutathione[1].

HY-Z1917S

*(S)-1-(6-amino-9H-purin-9-yl)propan-2-ol-d6*
(S)-1-(6-amino-9H-purin-9-yl)propan-2-ol-d6 is the deuterium labeled (S)-1-(6-amino-9H-purin-9-yl)propan-2-ol (Tenofovir Impurity）[1].

HY-W766569

*N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine-13C,d3*
N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine- ¹³C,d₃ is ¹³C and deuterated labeled N-Acetyl S-(1,2-dichlorovinyl)-L-cysteine.

HY-W040240S

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one-13C
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- ¹³C is the ¹³C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite[1].

HY-W040240S2

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one-13C-2
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- ¹³C-2 is the ¹³C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite[1].

HY-W040240S1

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one-13C-1
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- ¹³C-1 is the ¹³C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite[1].

HY-19717S

DCVC-13C3,15N
DCVC- ¹³C₃, ¹⁵N is ¹⁵N and ¹³C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures ^[1] .

HY-12355S

Siponimod-d11

Siponimod-d11 is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P₁ and S1P₅ over S1P₂, S1P₃, and S1P₄, with EC₅₀s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research ^[1] .

HY-N0565S1

Doxycycline-d3 (hyclate) (major)
Doxycycline-d3 hyclate (major) is the deuterium labeled Doxycycline-d3 hyclate (major) (HY-N0565S1) ^[1].

HY-143921S

Almorexant (αS,1S) isomer-13C,d3
Almorexant (αS,1S) isomer- ¹³C,d₃ is the ¹³C- and deuterium labeled Almorexant (αS,1S) isomer[1].

HY-113416AS

Dehydroepiandrosterone sulfate-d6 sodium dihydrate
Dehydroepiandrosterone sulfate-d₆ (sodium dihydrate) is the deuterium labeled tert-Butyl N-[(1S)-1-[Methoxy(methyl)carbamoyl]-2-phenylethyl]carbamate[1].

HY-10569S

Ponesimod-d4

Ponesimod-d₄ (ACT-128800-d₄) is the deuterium labeled Ponesimod (HY-10569) ^[1]. Ponesimod (ACT-128800) is a potent, selective and orally active agonist of S1P₁, with an IC₅₀ of 6 nM in a radioligand binding assay. Ponesimod activates S1P₁-mediated signal transduction with high potency (EC₅₀=5.7 nM). Ponesimod can protect against lymphocyte-mediated tissue inflammation .

HY-10569S1

Ponesimod-d7

Ponesimod-d₇ (ACT-128800-d₇) is the deuterium-labeled Ponesimod (HY-10569). Ponesimod-d₇ (ACT-128800) is a potent, selective and orally active agonist of S1P₁, with an IC₅₀ of 6 nM in a radioligand binding assay. Ponesimod-d₇ activates S1P₁-mediated signal transduction with high potency (EC₅₀=5.7 nM). Ponesimod-d₇ can protect against lymphocyte-mediated tissue inflammation ^[1] .

HY-W011338S

Benzyl butyl phthalate-d4

Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs)[2][3][4].

HY-B1811AS1

Vasopressin-d5 TFA

Vasopressin-d5 TFA is the TFA salt form of Vasopressin-d5 (HY-B1811S1). Vasopressin-d5 TFA is an isotope-labeled compound of Vasopressin (HY-B1811). Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of the corticotropin-releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors ^[1] .

HY-N1150S2

Thymidine-13C
Thymidine- ¹³C is the ¹³C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]

HY-N1150S6

Thymidine-d2
Thymidine-d₂ is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1

HY-Z4561S

Bortezomib trimer-d15
Bortezomib trimer-d₁₅ is deuterium labeled N,N',N''-((2S,2'S,2''S)-(((1R,1'R,1''R)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(1-oxo-3-phenylpropane-1,2-diyl))tris(pyrazine-2-carboxamide)（Bortezomib Impurity）.

HY-11063S1

Fingolimod-d4 hydrochloride
Fingolimod-d₄ (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].

HY-11063S

Fingolimod-d4
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

HY-N1150S5

Thymidine-2′-13C
Thymidine-2′- ¹³C is the ¹³C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]<

HY-N1150S1

Thymidine-d4
Thymidine-d₄ is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].

HY-N1150S

Thymidine-d3
Thymidine-d₃ is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].

HY-N1150S4

Thymidine-13C-2
Thymidine- ¹³C-2 is the ¹³C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]

HY-N1150S3

Thymidine-13C-1
Thymidine- ¹³C-1 is the ¹³C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]

HY-N1150S9

Thymidine-15N2
Thymidine- ¹⁵N₂ is the ¹⁵N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].

HY-172430S

Epaldeudomide
Epaldeudomide (Compound A406) is the inhibitor for TNF-α (>50% inhibition rate at 100 nM). Epaldeudomide inhibits the proliferation of cancer cells MM.1S (IC₅₀ < 300 nM), WSU-DLCL-2 (IC₅₀ < 100 nM) and Rec-1 (IC₅₀ < 100 nM). Epaldeudomide exhibits antineoplastic activity ^[1].

HY-128554S

N-Desethyl amodiaquine-d5
N-Desethyl amodiaquine-d₅ is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

HY-128554S1

N-Desethyl amodiaquine-d5 dihydrochloride
N-Desethyl amodiaquine-d₅ (dihydrochloride) is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

HY-N1150S8

Thymidine-13C10,15N2
Thymidine- ¹³C₁₀, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].

HY-N1150S10

Thymidine-d14
Thymidine-d₁₄ (DThyd-d₁₄; NSC 21548-d₁₄) is deuterium labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-N1150S11

Thymidine-13C10
Thymidine- ¹³C₁₀ (DThyd- ¹³C₁₀; NSC 21548- ¹³C₁₀) is ¹³C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

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Species:	Virus (47) Human (20) Rhesus Macaque (3) Mouse (7) Rat (2) Cynomolgus (2)
Tag:	His (61) SUMO (1) Tag Free (2) Avi (19) Myc (1) Fc (19) Flag (1)
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