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394

Inhibitors & Agonists

15

Screening Libraries

92

Fluorescent Dye

29

Biochemical Assay Reagents

30

Peptides

3

Inhibitory Antibodies

38

Natural
Products

13

Isotope-Labeled Compounds

6

Click Chemistry

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-109176
    Giredestrant
    5 Publications Verification

    GDC-9545; RG6171

    Estrogen Receptor/ERR Cancer
    Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity .
    Giredestrant
  • HY-101173

    VUF 8325 dihydrobromide; SKF 91105 dihydrobromide

    Histamine Receptor Neurological Disease
    Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM) .
    Imetit dihydrobromide
  • HY-19694

    Insulin Receptor Endocrinology
    BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and β cell function .
    BRD7552
  • HY-143618

    Biochemical Assay Reagents Cancer
    photoCORM-2 (compound 3) is a single carbon monoxide releasing molecule (CORM). photoCORM-2 exhibits good cellular uptake and real-time monitoring ability of CO uncaging by a color change approach. photoCORM-2 has anti-tumor activity .
    photoCORM-2
  • HY-B1495

    5-HT Receptor Neurological Disease
    Quipazine maleate is a 5-HT agonist that causes behavioural changes such as hyperactivity. Quipazine maleate also shows a weak reversible MAO inhibitory activity .
    Quipazine maleate
  • HY-162865

    FGFR Cancer
    FGFR2-IN-3 is an inhibitor of fibroblast growth factor receptor 2 (FGFR2). FGFR2-IN-3 has good binding properties, forming key interactions and inducing conformational changes in FGFR2. FGFR2-IN-3 can be used for research on tumors .
    FGFR2-IN-3
  • HY-20794

    Fluorescent Dye Others
    8-Hydroxyjulolidine is a chromophore moiety of a fluorescent probe for the detection of weak acid ions. 8-Hydroxyjulolidine can be used to synthesize the salicylaldehyde derivative 9-formyl-8-hydroxyjulolidine, which exhibits sensitive detection ability to pH changes of hydrogen sulfide and silicate in aqueous solution .
    8-Hydroxyjulolidine
  • HY-135903

    GDC-9545 tartrate; RG6171 tartrate

    Estrogen Receptor/ERR Cancer
    Giredestrant tartrate (GDC-9545 tartrate), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant tartrate potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Anti-tumor activity .
    Giredestrant tartrate
  • HY-143617

    Photosensitizer Cancer
    photoCORM-1 (compound 8) is a combinatorial carbon monoxide releasing molecule (CORM). photoCORM-1 exhibits good cellular uptake and real-time monitoring ability of CO uncaging by a color change approach. photoCORM-1 has anti-tumor antivity .
    photoCORM-1
  • HY-108648

    2-Methylthioadenosine diphosphate trisodium; 2-Methylthio-ADP trisodium

    P2Y Receptor Neurological Disease
    2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .
    2-MeS-ADP trisodium
  • HY-108648A

    2-Methylthioadenosine diphosphate; 2-Methylthio-ADP

    P2Y Receptor Neurological Disease
    2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-MeSADP has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-MeSADP induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .
    2-MeSADP
  • HY-145814

    HSP Fungal Infection
    HSP90-IN-9 is a potent and selective HSP90 inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2) .
    HSP90-IN-9
  • HY-161577

    Bcl-2 Family Cancer
    BFC1103 is a small-molecule compound whose primary mechanism of action involves interaction with a specific domain of Bcl-2, particularly its loop domain. This interaction induces a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homology 3) domain, thereby switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of Bax or Bak, both of which are key proteins involved in the intrinsic apoptotic pathway mediated by mitochondria. BFC1103 has successfully inhibited lung metastasis of triple-negative breast cancer in mouse models. It can be utilized in studying the roles of Bcl-2 family proteins in cancer development and how they impact the survival and proliferation of cancer cells .
    BFC1103
  • HY-143477

    Others Cardiovascular Disease
    Factor XI-IN-1 (Compound 27) is a factor XI activation inhibitor with an EC50 of 25.14 nM .
    Factor XI-IN-1
  • HY-N3765

    Apoptosis Metabolic Disease
    Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells .
    Diosbulbin D
  • HY-W011271

    1,4-Piperazinediethanesulfonic acid monosodium

    Biochemical Assay Reagents Others
    PIPES (1,4-Piperazinediethanesulfonic acid) monosodium is a pH buffer that can be mixed with another disodium salt form of PIPES. By changing the ratio and total amount of the PIPES monosodium and disodium buffers, the pH and ionic strength of the medium can be changed .
    PIPES monosodium
  • HY-118146

    Others Metabolic Disease
    Cicrotoic acid is an unsaturated fatty acid that increases bile flow and changes lipid composition .
    Cicrotoic acid
  • HY-122399

    Prostaglandin Receptor Endocrinology
    Luprostiol is a prostaglandin analog. Luprostiol can be used to stimulate endocrine changes in animals .
    Luprostiol
  • HY-N6600

    Others Others
    Octadecane is an alkane that is used to store thermal energy at ambient temperature as a phase change material .
    Octadecane
  • HY-136791

    Others Cardiovascular Disease
    BN 52115, a platelet-activating factor antagonist, has demonstrated the ability to mitigate bronchopulmonary changes in vivo.
    BN52115
  • HY-133608

    DNA/RNA Synthesis Inflammation/Immunology
    4,6-Dichloroguaiacol induces biochemical and morphological changes in human peripheral blood lymphocytes in vitro .
    4,6-Dichloroguaiacol
  • HY-D0084

    DiOC6(3) iodide

    Fluorescent Dye Others
    3,3'-Dihexyloxacarbocyanine iodide is a carbocyanine dye which can be used to monitor changes in mitochondrial membrane potential.
    3,3'-Dihexyloxacarbocyanine iodide
  • HY-B1307

    Cytochrome P450 Neurological Disease
    Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents.
    Zoxazolamine
  • HY-165054

    1-Palmitin-2-stearin-3-olein; TG(16:0/18:0/18:1)

    Biochemical Assay Reagents Others
    1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol (1-Palmitin-2-stearin-3-olein), a compound used in the study of changes in diglyceride and triglyceride molecular species in cells, was analyzed by neutral loss mass spectrometry and its content was found to change after cell activation.
    1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol
  • HY-B0871

    Herbicide Others
    Quinclorac, an herbicide widely applied in agriculture, induces oxidative stress due to free radical generation and changes in the antioxidant defense system .
    Quinclorac
  • HY-153804

    NCD

    Molecular Glues Others Cancer
    Naphthyridine caebamate dimer (NCD) is a DNA molecular glue that induces designed structural changes in target functional DNA to modulate function .
    Naphthyridine carbamate dimer
  • HY-W687496

    Vitamin A acid methyl ester

    Drug Derivative Others
    Methyl retinoate (Vitamin A acid methyl ester) is a derivative of vitamin A. Methyl retinoate causes degenerative changes in the seminiferous tubules in Sprague Dawley rats .
    Methyl retinoate
  • HY-D0169A
    Phenol Red sodium salt
    1 Publications Verification

    Phenolsulfonephthalein sodium salt

    Fluorescent Dye Others
    Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .
    Phenol Red sodium salt
  • HY-101891
    Di-8-ANEPPS
    1 Publications Verification

    Fluorescent Dye Others
    Di-8-ANEPPS is a naphthylstyryl voltage-sensitive dye, shifting both their fluorescence excitation and emission spectra upon changes in Vm .
    Di-8-ANEPPS
  • HY-N1427
    Glycodeoxycholate Sodium
    1 Publications Verification

    Sodium glycyldeoxycholate

    Endogenous Metabolite Metabolic Disease
    Glycodeoxycholate Sodium (Sodium glycyldeoxycholate) is a bile salt. Glycodeoxycholate Sodium has cytotoxicity to cancer cell, changes the permeability of the pancreatic duct and decreases glucose levels .
    Glycodeoxycholate Sodium
  • HY-N5126

    Others Neurological Disease
    Juncusol, a phenanthrenoid found in Juncus setchuenensis, possesses anxiolytic effect. Juncusol is associated with metabolic changes in cortical serotonin/dopamine levels in Mice .
    Juncusol
  • HY-D0169
    Phenol Red
    1 Publications Verification

    Phenolsulfonephthalein

    Fluorescent Dye Others
    Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .
    Phenol Red
  • HY-D0838

    Biochemical Assay Reagents Others
    Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction .
    Dodecyltrimethylammonium bromide
  • HY-160070

    Others Cancer
    Phorbol-12,13-didecanoate is an anti-viral TPA compound and a tumor promoter. It can cause changes in actin-containing structures [1] .
    Phorbol-12,13-didecanoate
  • HY-156787

    Photofrin II

    Endogenous Metabolite Cancer
    Porfimer sodium (Photofrin II) is a photosensitizing compound used primarily for photodynamic inhibition. Porfimer sodium is selectively taken up by tumor cells and can generate oxygen free radicals upon activation. Porfimer sodium causes changes in Ca(2+) concentrations within cells, exhibiting acute electrophysiological responses and changes in cell morphology. The application of porfimer sodium can lead to the formation of micropores on the cell membrane surface, resulting in necrotic cell death .
    Porfimer sodium
  • HY-147889

    Apoptosis Caspase Bcl-2 Family Others
    BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins .
    BBR-BODIPY
  • HY-163095

    Autophagy Neurological Disease
    RH1115 (compound 2c) is a modulator of the autophagy-lysosome. RH1115 induces changes to LAMP1 vesicle properties and alters lysosome positioning .
    RH1115
  • HY-135423

    Dy-DTPA-BMA

    Biochemical Assay Reagents Others
    Sprodiamide (Dy-DTPA-BMA) is a susceptibility-based MRI contrast agent that can be used to visualize image intensity changes during vascular transport of drugs .
    Sprodiamide
  • HY-123635

    Antibiotic Bacterial Infection
    Nybomycin, an antibiotic, exhibits antiphage and antibacterial properties. Nybomycin binds to DNA and induces a unique morphological change to mycobacterial bacilli leading the bacterial cell death .
    Nybomycin
  • HY-114805

    Insecticide Others
    Formothion is a compound used in agricultural production. Its residues can be detected in the environment after biomass burning, which is of great significance for studying the dynamic changes of pesticides in the environment.
    Formothion
  • HY-W014449

    Biochemical Assay Reagents Others
    4-Nitrophenyl butyrate consists of butyric acid chains esterified with 4-nitrophenol groups, thus giving it a yellow color. This compound is commonly used as a substrate in enzyme assays to measure esterase and lipase activity. When these enzymes cleave the ester bond, the nitrophenol group is released and the color changes from yellow to orange. Thus, the rate of color change can be used to determine enzyme activity. In addition, 4-Nitrophenyl butyrate can also be used as organic synthesis reagent and dye intermediate.
    4-Nitrophenyl butyrate
  • HY-108594

    Potassium Channel Metabolic Disease
    PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability .
    PD-118057
  • HY-125623

    Fluorescent Dye Others
    MitoPerOx is a fluorescent ratio-probe of lipid peroxidation. MitoPerOx can be taken up very rapidly into mitochondria within cells, thereby responding to changes in mitochondrial lipid peroxidation .
    MitoPerOx
  • HY-D1546

    Fluorescent Dye Cancer
    Biotin-C2-maleimide is an antibody conjugate reagent, can bind to many biomolecules without significantly changing the biological activity of the target molecule .
    Biotin-C2-maleimide
  • HY-N6600S

    Isotope-Labeled Compounds Others
    Octadecane-d38 is the deuterium labeled Octadecane[1]. Octadecane is an alkane that is used to store thermal energy at ambient temperature as a phase change material[2].
    Octadecane-d38
  • HY-P9962

    Fungal Infection
    Efungumab is a monoclonal antibody with antifungal activity. Efungumab binds to HSP 90, preventing a conformational change needed for fungal viability. Efungumab can be used for research on invasive candidiasis (IC) .
    Efungumab
  • HY-D1777

    PM605

    Fluorescent Dye Others
    Pyrromethene 605 (PM605) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.
    Pyrromethene 605
  • HY-W248118

    PM556

    Fluorescent Dye Others
    Pyrromethene 556 (PM556) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.
    Pyrromethene 556
  • HY-W248583

    PM650

    Fluorescent Dye Others
    Pyrromethene 650 (PM650) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.
    Pyrromethene 650
  • HY-165037

    MME; 1,2-Myristin-3-eicosapentaenoin; 14:0/14:0/20:5-TG

    Drug Isomer Others
    1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol (MME) is a compound that is studied as a triglyceride isomer in algae, and its isomer ratio changes with culture temperature.
    1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol

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