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Isoforms Recommended:	Estrogen receptor

Results for "

ER

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (339) Cardiovascular Disease (14) Endocrinology (39) Infection (38) Inflammation/Immunology (52) Metabolic Disease (29) Neurological Disease (35)
Click Chemistry:	Azide (4)

464

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108531

ER 50891	RAR/RXR	Cancer
ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). ER-50891 significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis .

HY-100852

ER-000444793 2 Publications Verification	Mitochondrial Metabolism	Cancer
ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. ER-000444793 inhibits mPTP with an IC₅₀ of 2.8?μM.

HY-42484

ER-076349	Microtubule/Tubulin	Cancer
ER-076349 is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 inhibits cancer cell growth, and inhibits tumor growth in several human tumor xenografts. ER-076349 is an analog of Halichondrin B .

HY-138961

ER-27319	Syk	Inflammation/Immunology
ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases .

HY-108489

ER-27319 maleate	Syk	Inflammation/Immunology
ER-27319 (maleate), an acridone derivative, is a potent and selective SKY inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 (maleate) inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC₅₀ of 10 μM and can be used for study in allergic diseases ^[1] ^[2].

HY-168271

ER ligand-2	Ligands for Target Protein for PROTAC Estrogen Receptor/ERR	Cancer
ER ligand-2 (Ligands for Target Protein for Compound 24) is the ligand of ER. ER ligand-2 can be used for synthesis PROTAC ER Degrader-11 (HY-168270) .

HY-163812

ER degrader 9	Molecular Glues Estrogen Receptor/ERR	Cancer
ER degrader 9 (compound 1), a bifunctional molecular glue, is a potent estrogen receptor (ER) degrader with a DC₅₀ of ≤10 nM in MCF-7 cells. ER degrader 9 can be used for the research of breast cancer .

HY-164382

ER-851	TAM Receptor	Cancer
ER-851 is a selective AXL inhibitor with oral activity with IC₅₀ of 100 nM. ER-851 has antitumor activity .

HY-156722

ER-34122	COX Lipoxygenase	Inflammation/Immunology
ER-34122 is a dual 5-lipoxygenase/cyclooxygenase inhibitor with oral activity. ER-34122 has anti-inflammatory activity .

HY-116099

ER-819762	Prostaglandin Receptor	Inflammation/Immunology
ER-819762 is an orally active, highly selective prostaglandin E₂ (PGE₂) EP₄ receptor antagonist with an EC₅₀ of 70 nM against human EP₄ receptor. ER-819762 can be used for rheumatoid arthritis research .

HY-108531A

ER 50891 quarterhydrate	RAR/RXR	Cancer
ER 50891 quarterhydrate is a potent antagonist of retinoic acid receptor α(RARα). ER 50891 quarterhydrate significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis .

HY-101826A

ER21355 hydrochloride	Phosphodiesterase (PDE)	Cancer
ER21355 hydrochloride is the hydrochloride form of ER21355 (HY-101826). ER21355 hydrochloride is an inhibitor for phosphodiesterase (PDE), which is potent for ameliorating benign prostatic hyperplasia (BPH) and prostatism through increasing levels of cAMP and cGMP, and resulting a relaxation of the smooth muscle cell .

HY-169978

ER ligand-3	Ligands for Target Protein for PROTAC	Cancer
ER ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). ER ligand-3 can be used for the synthesis of PROTAC ER Degrader-12 (HY-160264) .

HY-D2323

ER PhotoFlipper 32	Fluorescent Dye	Others
ER-PhotoFlipper 32 is a ER tracker. ER-PhotoFlipper 32 can selectively label the inner leaflet of the plasma membrane with Flipper-TR 5 (HY-D2318). The ER-tracker attaches the PhotoFlipper covalently to the outer surface of the ER. ER-PhotoFlipper 32 can be applied to access plasma membrane asymmetry .

HY-P10802

ER-DRI	Enterovirus Virus Protease	Infection
ER-DRI is a potent peptide inhibitor that tagets EV-A71. ER-DRI directly bounds to 3A and specifically abrogates viral suppressor of RNAi activity, which unlocked the antiviral RNAi response that is suppressed by 3A. ER-DRI also potently inhibits another enterovirus, Coxsackievirus-A16, dependently of RNAi .

HY-170341

ER ligand-6	Ligands for Target Protein for PROTAC Estrogen Receptor/ERR	Cancer
ER ligand-6 is a target protein ligand of PROTAC ER Degrader-14 (HY-170340) .

HY-149970

ER degrader 5	Estrogen Receptor/ERR	Cancer
ER degrader 5 is a potent estrogen receptor (ER) degrader. ER degrader 5 shows anti-proliferation activity. ER degrader 5 can be used for the research of breast cancer .

HY-153010

ER proteostasis regulator-1	PERK	Neurological Disease Metabolic Disease
ER proteostasis regulator-1 (compound 481) is a potent ER proteostasis regulator. ER proteostasis regulator-1 has the potential for the research of Alzheimer's disease and diabetes .

HY-201580

ER ligand-8	Estrogen Receptor/ERR Ligands for Target Protein for PROTAC	Cancer
ER ligand-8 is an ER (Estrogen Receptor/ERR) ligand that can be used to synthesize the PROTAC molecule ERD-1233 (HY-169367) .

HY-155196

ER degrader 6	Estrogen Receptor/ERR	Cancer
ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER)α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness .

HY-170382

ER covalent antagonist-1	Estrogen Receptor/ERR Apoptosis	Cancer
ER covalent antagonist-1 (Compound 39D) is the antagonist for estrogen receptor α (ERα). ER covalent antagonist-1 inhibits the proliferation of ERα-positive cell MCF-7 with an IC₅₀ of 0.98 μM, arrests the cell cycle at G0/G1 phase, and induces apoptosis. ER covalent antagonist-1 exhibits antitumor efficacy in mouse model .

HY-170334

ER ligand-7	Estrogen Receptor/ERR Ligands for Target Protein for PROTAC	Cancer
ER ligand-7 is the ligand for estrogen receptor, and can be used for synthesis of PROTAC ER Degrader-15 (HY-170332) as ligand for target protein .

HY-170377

ER degrader 10	Estrogen Receptor/ERR Potassium Channel	Cancer
ER degrader 10 (Compound 51) is a selective, orally active degrader and antagonist for estrogen receptor (ER) with a DC₅₀ of 0.43 nM and an IC₅₀ of 0.56 nM. ER degrader 10 inhibits the proliferation of ER-positive cells with IC₅₀s of 0-15 nM. ER degrader 10 exhibits a weak inhibitory activity against hERG channel with an IC₅₀ >40 μM. ER degrader 10 is blood-brain barrier penetrable with a brain/plasma ratio (Kp) of 3.05. ER degrader 10 exhibits antitumor efficacy in mice model .

HY-170339

ER ligand-5	Estrogen Receptor/ERR Ligands for Target Protein for PROTAC	Cancer
ER ligand-5 is the ligand for estrogen receptor, that can be used as ligand for target protein for PROTAC synthesis of PROTAC ERα Degrader-10 (HY-170336) .

HY-101826

ER21355	Phosphodiesterase (PDE)	Cancer
ER21355 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.

HY-155197

ER degrader 7	Microtubule/Tubulin Estrogen Receptor/ERR	Cancer
ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. ER degrader 7 inhibits tubulin polymerization. ER degrader 7 inhibits cell viability with IC₅₀s of 0.06, 2.56, 15.84, 1.59, 1.67, 1.37 μM for MCF-7, T47D, MCF-10A, LCC2, T47D D538G, and T47D Y537S cells respectively. ER degrader 7 also inhibits breast cancer tumor growth .

HY-149969

ER degrader 4	Estrogen Receptor/ERR	Cancer
ER degrader 4 is a selective and orally active estrogen receptor degrader. ER degrader 4 has anti-tumor activity .

HY-14272

Ravuconazole BMS-207147; ER-30346	Fungal	Infection Cancer
Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.

HY-142926

ER degrader 2	Estrogen Receptor/ERR	Cancer
ER degrader 2 is a potent degrader of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. ER degrader 2 has the potential for the research of cancer diseases (extracted from patent CN112830919A, compound 1) .

HY-D2320

ER Flipper-TR 28	Fluorescent Dye	Others
ER Flipper-TR 28 is a flipper probe with a small molecule fluorophore that can image membrane tension in the endoplasmic reticulum (ER). ER Flipper-TR 28 bears a pentafluorophenyl group and also reacts with protein thiolate on the ER surface facing the cytoplasm .

HY-142925

ER degrader 1	Estrogen Receptor/ERR	Cancer
ER degrader 1 is a potent degrader of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. ER degrader 1 has the potential for the research of cancer diseases (extracted from patent WO2021139756A1, compound 11) .

HY-142927

ER degrader 3	Estrogen Receptor/ERR	Cancer
ER degrader 3 is a potent degrader of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. ER degrader 3 has the potential for the research of cancer diseases (extracted from patent WO2018233591A1, compound 1) .

HY-141804

ER176	Biochemical Assay Reagents	Neurological Disease
ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein (TSPO), a biomarker for neuroinflammation .

HY-164925

ER ligand-4	Ligands for Target Protein for PROTAC	Cancer
ER ligand-4 (compound 45a) is an PROTAC target protein ligand of HY-164924 .

HY-172067

ER ligand-9	Estrogen Receptor/ERR Target Protein Ligand-Linker Conjugates	Cancer
ER ligand-9 is a conjugate of an estrogen receptor (Estrogen Receptor/ERR) and a linker, which can be used to synthesize ERD-1233 (HY-169367) .

HY-D1297

ER-Tracker Green	Fluorescent Dye	Others
ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation .

HY-D1422

ER Thermo Yellow BDNCA-346	Fluorescent Dye
ER Thermo Yellow is an endoplasmic reticulum-targeted temperature-visible fluorescent probe with high sensitivity (3.9%/°C).

HY-D1431

ER-Tracker Red 1 Publications Verification	Fluorescent Dye	Cancer
ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation. Ex/Em=587/615 nm .

HY-15496

E6201 ER-806201	MEK FLT3	Cancer
E6201 (ER-806201) is an ATP-competitive dual kinase inhibitor of MEK1 and FLT3. E6201 inhibits MEK1- induced ERK2 phosphorylation with an IC₅₀ value of 5.2 nM, MKK4-induced JNK phosphorylation with an IC₅₀ value of 91 nM, and MKK6-induced p38 MAPK phosphorylation with an IC₅₀ value of 19 nM. Anti-tumor and anti-psoriasis efficacy .

HY-14571

E7820 4 Publications Verification ER68203-00	Molecular Glues Integrin	Cancer
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC₅₀ of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. Antiangiogenic and antitumor activity .

HY-168101

ERα degrader 11	Estrogen Receptor/ERR	Cancer
ERα degrader 11 (compound B16) is a selective ERα degrader that can be used as an estrogen receptor probe to investigate ER status in ER-positive breast cancer cells .

HY-D1429

ER-Tracker Blue-White DPX	Fluorescent Dye	Others
ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation .

HY-149480

ERD-3111	PROTACs Estrogen Receptor/ERR	Cancer
ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC₅₀: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer .

HY-169941

ERα/ERβ antagonist-1	Estrogen Receptor/ERR	Metabolic Disease Cancer
ERα/ERβ antagonist-1 (Compound 10) is partial antagonists of ERα and ERβ. ERα/ERβ antagonist-1 reduces ERα and ERβ activity in a dose-dependent manner in HepG2 liver cells .

HY-168099

ERα degrader 10	Estrogen Receptor/ERR	Cancer
ERα degrader 10 is a selective and orally active estrogen receptor α (ERα) degrader. ERα degrader 10 exhibits potent ERα binding affinity (IC₅₀ of 24.0 nM) and degradation ability (EC₅₀ of 5.3 nM). ERα degrader 10 degrades ERα through the proteasome-mediated pathway. ERα degrader 10 can be used for the study of breast cancer .

HY-146267

ERα degrader 5	Estrogen Receptor/ERR	Cancer
ERα degrader 5 (Compound 40) is a selective, orally bioavailable estrogen receptor (ER) degrader (SERD) with an EC₅₀ of 1.1 nM against ERα. ERα degrader 5 shows antitumor effect in vivo .

HY-163680

ERα degrader 9	Estrogen Receptor/ERR Cytochrome P450	Cancer
ERα degrader 9 is a dual targeting ligand for estrogen receptor α (ERα) and aromatase (ARO). ERα degrader 9 can be utilized for synthesis of PROTAC ERα Degrader-9 (HY-163679) .

HY-149081

ERα degrader 6	Estrogen Receptor/ERR Cytochrome P450	Cancer
ERα degrader 6 (Compound 31q) is an ERα degrader (K_I: 75 nM). ERα degrader 6 also inhibits ARO with an IC₅₀ of 37.7 nM. ERα degrader 6 inhibits tumor growth in MCF-7 tumor xenograft model. ERα degrader 6 can be used for breast cancer research .

HY-128600

ERD-308 1 Publications Verification	PROTACs Estrogen Receptor/ERR	Cancer
ERD-308 is a highly potent von Hippel-Lindau-based PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC₅₀ (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively) .

HY-18200

Atopaxar E5555; ER-172594-00	Protease Activated Receptor (PAR) JAK Apoptosis	Cardiovascular Disease Cancer
Atopaxar (E5555) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar, an antiplatelet agent, interferes with platelet signaling. Atopaxar can be used for the research of atherothrombotic disease .

Cat. No.	Product Name

HY-L054

Endoplasmic Reticulum Stress Compound Library

237 compounds

Endoplasmic reticulum (ER) contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of Endoplasmic reticulum stress (ER stress, ERS) and unfolded protein response (UPR) signaling pathways. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration and cancer.

MCE Endoplasmic Reticulum Stress Compound Library contains 237 ER stress-related compounds that mainly target PERK, IRE1, ATF6, etc. MCE ER stress library is a useful tool for researching ER stress and related diseases.

HY-L129

Target Protein Ligand Library

55 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 55 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

Cat. No.	Product Name	Type

HY-D1297

ER-Tracker Green

Fluorescent Dyes/Probes

ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation .

HY-D1422

ER Thermo Yellow BDNCA-346	Fluorescent Dyes/Probes
ER Thermo Yellow is an endoplasmic reticulum-targeted temperature-visible fluorescent probe with high sensitivity (3.9%/°C).

HY-D1431

ER-Tracker Red

1 Publications Verification

Fluorescent Dyes/Probes

HY-D1429

ER-Tracker Blue-White DPX

Fluorescent Dyes/Probes

HY-D2299

AIE-ER	Fluorescent Dyes/Probes
AIE-ER is a specific endoplasmic reticulum (ER) fluorescent probe (green channel: λ_ex=405 nm, λ_em=450~650 nm) that exhibits remarkable photostability, high brightness, and low working concentration. AIE-ER may provide an avenue for studying diseases related to the endoplasmic reticulum .

HY-D1498

Mag-Fluo-4 AM 1 Publications Verification	Fluorescent Dyes/Probes
Mag-Fluo-4 AM is a fluorecent Ca ²⁺ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .

HY-D2323

ER PhotoFlipper 32	Fluorescent Dyes/Probes
ER-PhotoFlipper 32 is a ER tracker. ER-PhotoFlipper 32 can selectively label the inner leaflet of the plasma membrane with Flipper-TR 5 (HY-D2318). The ER-tracker attaches the PhotoFlipper covalently to the outer surface of the ER. ER-PhotoFlipper 32 can be applied to access plasma membrane asymmetry .

HY-D2320

ER Flipper-TR 28	Fluorescent Dyes/Probes
ER Flipper-TR 28 is a flipper probe with a small molecule fluorophore that can image membrane tension in the endoplasmic reticulum (ER). ER Flipper-TR 28 bears a pentafluorophenyl group and also reacts with protein thiolate on the ER surface facing the cytoplasm .

HY-D0728

Fluorescent Brightener ER-III	Dyes
Fluorescent Brightener ER-III is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-162129

Antitumor agent-131	Fluorescent Dyes/Probes
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC₅₀ value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .

HY-12591

D-Luciferin sodium

Maximum Cited Publications

46 Publications Verification

D-(-)-LucifERin sodium; Firefly lucifERin sodium; Beetle LucifERin sodium

Chromogenic Substrates

D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .

HY-12591A

D-Luciferin

Maximum Cited Publications

46 Publications Verification

D-(-)-LucifERin; Firefly lucifERin; Beetle LucifERin

Chromogenic Substrates

Cat. No.	Product Name	Target	Research Area

HY-129960

L-Selenocystine	Peptides	Others
L-Selenocystine is a diselenide-bridged amino acid. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions. L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types .

HY-P3833A

Yp537 TFA Anti-estrogen TFA	Estrogen Receptor/ERR	Endocrinology
Yp537 TFA is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor .

HY-P1556A

Vasonatrin Peptide (VNP) TFA	PKG	Metabolic Disease
Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .

HY-P10802

ER-DRI	Enterovirus Virus Protease	Infection
ER-DRI is a potent peptide inhibitor that tagets EV-A71. ER-DRI directly bounds to 3A and specifically abrogates viral suppressor of RNAi activity, which unlocked the antiviral RNAi response that is suppressed by 3A. ER-DRI also potently inhibits another enterovirus, Coxsackievirus-A16, dependently of RNAi .

HY-P10393

ERα17p ERα (295-311)	Apoptosis	Cancer
ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D, and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathways. ERα17p inhibits proliferations of breast cancer cells, induces apoptosis, and inhibits tumor growth in mouse models .

HY-P3833

Yp537 Anti-estrogen	Estrogen Receptor/ERR	Endocrinology
Yp537 is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor .

HY-P10374

Pep42	Peptides	Cancer
Pep42, a cyclic peptide ligand of GPR78, internalizes selectively into highly metastatic human melanoma cells through a receptor-mediated process .

HY-P10843

R4K1	Estrogen Receptor/ERR	Cancer
R4K1 is a cell-permeable stapled peptide. R4K1 binds to the estrogen receptor (ER) α with high affinity and inhibits its interaction with coactivators. R4K1 can enter breast cancer cells to regulate gene transcription and inhibit cell proliferation. R4K1 can be used in the study of cancer .

HY-P1556

Vasonatrin Peptide (VNP)	PKG	Cardiovascular Disease
Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway .

HY-P5344

Dabcyl-LNKRLLHETQ-Edans Fluorigenic PEXEL peptide	Parasite	Others
Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)

HY-P3444

CD31 PECAM-1	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P3444A

CD31 TFA PECAM-1 TFA	SHP2 Bacterial	Metabolic Disease Inflammation/Immunology
CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation ^- .

HY-P4190

Fsh receptor-binding inhibitor fragment(bi-10)	GnRH Receptor	Endocrinology
FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries .

HY-P10445

TAT-PiET	Epigenetic Reader Domain	Cancer
TAT-PiET is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4 that disrupts the BRD4/JMJD6 interaction. BRD4/JMJD6 is a protein complex that is critical for oncogene expression and breast cancer, and TAT-PiET inhibits BRD4/JMJD6 target gene expression and breast cancer cell growth. TAT-PiET also resists endocrine resistance in ERα-positive breast cancer cells and is a potential inhibitor of breast cancer .

HY-P10446

TAT-PiET-PROTAC	Radionuclide-Drug Conjugates (RDCs) Epigenetic Reader Domain	Cancer
TAT-PiET-PROTAC is a proteolysis-targeting chimera (PROTAC)-modified TAT-PiET (HY-P10445). TAT-PiET is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC can disrupt the interaction between the breast cancer oncogene BRD4/JMJD6 and inhibit the growth of breast cancer cells. TAT-PiET-PROTAC also resists the endocrine resistance of ERα-positive breast cancer cells and is a potential inhibitor of breast cancer . TAT-PiET-PROTAC can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

Cat. No.	Product Name	Target	Research Area

HY-P99683

Ladiratuzumab vedotin SGN-LIV1A	Antibody-Drug Conjugates (ADCs)	Cancer
Ladiratuzumab vedotin (SGN-LIV1A) is a LIV-1 targeting antibody drug conjugate (ADC) (IC₅₀: 5.6 nM for LIV-1). Ladiratuzumab vedotin consists of humanized IgG1 monoclonal antibody, MMAE and a protease-cleavable linker. Ladiratuzumab vedotin can drive immunogenic cell death (ICD) to elicit an immune response. Ladiratuzumab vedotin can be used for research of breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1443

Demethylcantharidate disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer .

HY-N9329

Glicoricone	Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones	Monoamine Oxidase Estrogen Receptor/ERR
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity .

HY-13433

Thapsigargin 65+ Cited Publications	Infection Classification of Application Fields Terpenoids Source classification Diterpenoids Umbelliferae Plants Disease Research Fields Thapsia garganica L. Cancer	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-A0098

Tunicamycin Maximum Cited Publications 98 Publications Verification	Structural Classification Antifungal Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Antiviral Anticancer Inflammation/Immunology Disease Research Fields	Bacterial Fungal Influenza Virus Antibiotic
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity .Tunicamycin increases exosome release in cervical cancer cells .

HY-100583A

(±)-Equol	Cardiovascular Disease Structural Classification Monophenols Neurological Disease Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Plants Disease Research Fields	Estrogen Receptor/ERR Drug Metabolite
(±)-Equol is the racemate of equol. (±)-equol exhibits EC₅₀s of 200 and 74 nM for human ERα and ERβ, respectively. Equol is a metabolite of the soy isoflavones, daidzin and daidzein.

HY-N0233

Bavachin 5+ Cited Publications Corylifolin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Cancer	Estrogen Receptor/ERR
Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC₅₀s of 320 and 680 nM, respectively.

HY-19332

Kifunensine 5+ Cited Publications FR-900494	Alkaloids Piperidine Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Others
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

HY-N3642

Cristacarpin ERythrabyssin I; ERythrabissin I	Leguminosae Erythrina suberosa Roxb. Source classification Plants	Others
Cristacarpin can be extracted from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sublethal reactive oxygen species (ROS) production and ultimately cell death through senescence .

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-N0233R

Bavachin (Standard)	Structural Classification Flavonoids Leguminosae Flavonones Source classification Phenols Polyphenols Psoralea corylifolia L. Plants	Estrogen Receptor/ERR
Bavachin (Standard) is the analytical standard of Bavachin. This product is intended for research and analytical applications. Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC50s of 320 and 680 nM, respectively.

HY-N1260

Scutebarbatine A (-)-Scutebarbatine A	Alkaloids Structural Classification Classification of Application Fields Labiatae Source classification Derris robusta Pyridine Alkaloids Plants Disease Research Fields Cancer	Apoptosis
Scutebarbatine A inhibits the proliferation of HCC cells and triggers their apoptosis via the activation of MAPK and ER stress .

HY-B0412

Estriol 4 Publications Verification Oestriol	Structural Classification Monophenols Immune System Disorder Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite
Estriol (Oestriol), an orally active estrogen, is a ERα and ERβ agonist. Estriol is a potent GPR30 antagonist in estrogen receptor-negative breast cancer cells. Estriol can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Estriol has powerful proconvulsant effects .

HY-Y1309

1-Naphthol Furro ER; NSC 9586; Nako TRB	Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe.

HY-125703

Ferutinin	Viguiera dentata (Cav.) Spreng. Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Umbelliferae Plants Disease Research Fields Endocrinology Cancer	Estrogen Receptor/ERR Apoptosis
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca ²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities .

HY-N2448

Lindleyin	Classification of Application Fields Rheum palmatum L. Polygonaceae Source classification Phenols Polyphenols Plants Disease Research Fields Endocrinology	Estrogen Receptor/ERR
Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity .

HY-N0377

Liquiritigenin 5+ Cited Publications 4',7-Dihydroxyflavanone	Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Flavonoids Microorganisms Leguminosae Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Estrogen Receptor/ERR
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

HY-19696

Tauroursodeoxycholate 65+ Cited Publications Tauroursodeoxycholic acid; TUDCA; UR 906	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N0878

Bufotalin 4 Publications Verification	Structural Classification Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	Apoptosis Reactive Oxygen Species
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation .

HY-19696A

Tauroursodeoxycholate sodium 65+ Cited Publications Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-U00141

ABTL-0812 α-Hydroxylinoleic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Bombacaceae Source classification Metabolic Disease Plants Pachira aquatica Aublet Disease Research Fields	Autophagy
ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity .

HY-N0139

Troxerutin 1 Publications Verification Trihydroxyethylrutin	Flavonols Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Monophenols Flavonoids other families Phenols Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.

HY-19696B

Tauroursodeoxycholate dihydrate 65+ Cited Publications Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK .

HY-N7875

Celangulin	Structural Classification Natural Products Source classification Celastraceae Celastrus angulatus Maxim. Plants	Others
Celangulin is an insecticidal component isolated from Celastrus angulatus. Celangulin activates the calcium channel on the plasma membrane with increasing the intracellular Ca ²⁺ after influx from the external. Celangulin activates the calcium channel in the ER .

HY-N12023

Deacetylnomilin	Triterpenes Structural Classification Natural Products Terpenoids Source classification Rutaceae Plants Citrus reticulata Blanco	Bacterial Fungal
Deacetylnomilin can be isolated from Citrus reticulata and has antibacterial and antifungal activity. Deacetylnomilin is a potent inhibitor of cell proliferation with an IC₅₀ value of 0.005 ug/mL against estrogen receptor-positive (ER+) cells .

HY-N0120A

Polydatin 5+ Cited Publications Piceid	Structural Classification Classification of Application Fields Anti-aging Polygonaceae Reynoutria japonica Houtt. Source classification Plants Stilbenes Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Autophagy Apoptosis Mitophagy
Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

HY-W011241

Cinchonine hydrochloride (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride	Alkaloids other families Classification of Application Fields Source classification Quinoline Alkaloids Plants Disease Research Fields Cancer	Apoptosis Parasite
Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells .

HY-N4121

Isocurcumenol 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Cancer	Estrogen Receptor/ERR Apoptosis
Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC₅₀ values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively .

HY-N0791

Tectoridin 1 Publications Verification	Structural Classification Flavonoids Flavones Leguminosae Maackia amurensis Rupr. et Maxim. Plants	Estrogen Receptor/ERR
Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway .

HY-135319

Strictinin	Structural Classification Source classification Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Theaceae	Others
Strictinin is a phenolic compound isolated from Pu'er teas. Strictinin has potential antiviral, antibacterial and laxative activities. Strictinin occurs by accelerating intestinal transit rather than enhancing gastric emptying, increasing food intake, or inducing diarrhea in rats.

HY-N7748A

Epi-cryptoacetalide	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Estrogen Receptor/ERR Prostaglandin Receptor
Epi-cryptoacetalide is a natural diterpenoid. Epi-cryptoacetalide reveals high affinity to *ER-α* and PGE2 receptor (EP2 subtype) with K_i values of 0.3 μM and 1.92 μM, respectively. Epi-cryptoacetalide has anti-endometriosis activities .

HY-N11600

β-Apopicropodophyllin	Structural Classification Labiatae Varthemia iphionoides Boiss Source classification Lignans Phenylpropanoids Plants	Apoptosis
β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer .

HY-19696R

Tauroursodeoxycholate (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate (Standard) is the analytical standard of Tauroursodeoxycholate. This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-N11973

5,7-Dimethoxy-2,3-phenanthrenediol	Structural Classification Dioscorea polystachya Turczaninow Source classification Phenols Polyphenols Plants Dioscoreaceae	Others
5,7-Dimethoxy-2,3-phenanthrenediol is a compound with estrogenic activity. 5,7-Dimethoxy-2,3-phenanthrenediol increases the proliferation of MCF-7 cell and the expression of ERβ in the MCF-7 cell line .

HY-N0139R

Troxerutin (Standard) Trihydroxyethylrutin (Standard)	Structural Classification Flavonoids other families Neurological Disease Classification of Application Fields Source classification Phenols Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
Troxerutin (Standard) is the analytical standard of Troxerutin. This product is intended for research and analytical applications. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.

HY-114297

Zymosterol 1 Publications Verification	Structural Classification Microorganisms Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell .

HY-N3239

Mulberrofuran G	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	NADPH Oxidase HBV
Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress . Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC₅₀ of 3.99 μM .

HY-107803

Geranium oil	Structural Classification Natural Products Source classification Plants Geraniaceae	Estrogen Receptor/ERR
Geranium oil serves as a partial agonist for estrogen receptor (ER), enhancing both the cytotoxicity induced by Tamoxifen (TMX) (HY-13757A) in GT1-7 cells and the adverse effects of TMX on the central nervous system. Geranium oil can be utilized in the research of neurological disorders such as dementia .

HY-N0120AR

Polydatin (Standard) 5+ Cited Publications Piceid (Standard)	Structural Classification Stilbenes Classification of Application Fields Anti-aging Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Plants Inflammation/Immunology Disease Research Fields Cancer	Autophagy Apoptosis Mitophagy
Polydatin (Standard) is the analytical standard of Polydatin. This product is intended for research and analytical applications. Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.

HY-N0791R

Tectoridin (Standard)	Structural Classification Flavonoids Flavones Leguminosae Maackia amurensis Rupr. et Maxim. Plants	Estrogen Receptor/ERR
Tectoridin (Standard) is the analytical standard of Tectoridin. This product is intended for research and analytical applications. Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway .

HY-114367

Delphinidin 3-rutinoside chloride Delphinidin 3-O-rutinoside chloride	Structural Classification Anthocyans Flavonoids Classification of Application Fields Solanum melongena L. Source classification Phenols Polyphenols Plants Solanaceae Disease Research Fields Cancer	Apoptosis
Delphinidin 3-rutinoside chloride (Delphinidin 3-O-rutinoside chloride) is an active anthocyanin found in Solanum melongena. Delphinidin 3-rutinoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL) . Delphinidin 3-rutinoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC₅₀ of 2.3 μM .

HY-N6052

(+)-Medicarpin	Monophenols other families Classification of Application Fields Terpenoids Source classification Phenols Diterpenoids Plants Disease Research Fields Cancer	Estrogen Receptor/ERR
(+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action .

HY-12956

Dinoprost 2 Publications Verification Prostaglandin F2α; PGF2α	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .

HY-12956A

Dinoprost tromethamine salt 2 Publications Verification Prostaglandin F2α tromethamine salt; PGF2α THAM; Prostaglandin F2α THAM	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .

HY-12956R

Dinoprost (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
Dinoprost (Standard) is the analytical standard of Dinoprost. This product is intended for research and analytical applications. Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .

HY-12956AR

Dinoprost (tromethamine salt) (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
Dinoprost (tromethamine salt) (Standard) is the analytical standard of Dinoprost (tromethamine salt). This product is intended for research and analytical applications. Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .

HY-N0835R

(20S)-Protopanaxatriol (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol (Standard) is the analytical standard of (20S)-Protopanaxatriol. This product is intended for research and analytical applications. (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-N1435

Oroxin B 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Cancer	Apoptosis PI3K PTEN Autophagy
Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-N2025

Oroxin A	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Metabolic Disease Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields	PPAR Glycosidase
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-N0401A

(Z)-Ligustilide 3 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields	Bacterial Estrogen Receptor/ERR FATP
(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6 . (Z)-Ligustilide is orally active, it inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) . (Z)-Ligustilide is also able to reactivate ERα, has epigenetic regulation, and is used in the study of tamoxifen-resistant breast cancer .

Species:	Human (17) Mouse (1)
Tag:	GFP (1) His (16) Tag Free (1) GST (1) Flag (1)
Source:	HEK293 (8) E. coli Cell-free (1) P. pastoris (2) Sf9 insect cells (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P70248

	ER alpha/ESR1 Protein, Human (His) 1 Publications Verification rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A MembER 1; ESR1; ESR; NR3A1	Human	E. coli
	The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701106

	ER alpha/ESR1 Protein, Human (P. pastoris, N-His) rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A MembER 1; ESR1; ESR; NR3A1	Human	P. pastoris
	The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (P. pastoris, N-His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P70791

	ER beta/ESR2 Protein, Human (His) Estrogen Receptor Beta; ER-Beta; Nuclear Receptor Subfamily 3 Group A MembER 2; ESR2; ESTRB; NR3A2	Human	E. coli
	ER beta/ESR2 Protein, a nuclear hormone receptor, binds estrogens akin to ESR1/ER-alpha. It activates estrogen-dependent reporter genes with ERE. However, it lacks ligand binding ability and exhibits minimal ERE binding, resulting in the loss of ligand-dependent transactivation ability. ER beta/ESR2 Protein, Human (His) is the recombinant human-derived ER beta/ESR2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ER beta/ESR2 Protein, Human (His) is 323 a.a., with molecular weight of 35-40 kDa.

HY-P7011

	Epiregulin Protein, Human 2 Publications Verification rHuEpiregulin; EREG; EPR	Human	E. coli
	Epiregulin Protein, Human is a growth regulator and a member of the epidermal growth factor (EGF) family. Epiregulin is a tumor growth-inhibitory factor inducing morphological changes in human epidermoid carcinoma HeLa cells.

HY-P71113

	PDIA4 Protein, Human (HEK293, His) Protein Disulfide-IsomERase A4; Endoplasmic Reticulum Resident Protein 70; ER Protein 70; ERp70; Endoplasmic Reticulum Resident Protein 72; ER Protein 72; ERp-72; ERp72; PDIA4; ERP70; ERP72	Human	HEK293
	The PDIA4 protein plays a key role in the chaperone complex, cooperating with various proteins. This dynamic assembly, including DNAJB11, HSP90B1 and others, orchestrates complex cellular processes. PDIA4 Protein, Human (HEK293, His) is the recombinant human-derived PDIA4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDIA4 Protein, Human (HEK293, His) is 625 a.a., with molecular weight of ~75.0 kDa.

HY-P70957

	MAN1B1 Protein, Human (HEK293, His) Endoplasmic Reticulum Mannosyl-Oligosaccharide 1; 2-Alpha-Mannosidase; ER Alpha-1; 2-Mannosidase; ER Mannosidase 1; ERMan1; Man9GlcNAc2-Specific-Processing Alpha-Mannosidase; Mannosidase Alpha Class 1B MembER 1; MAN1B1	Human	HEK293
	MAN1B1, integral to glycoprotein quality control, trims a single alpha-1,2-linked mannose from Man(9)GlcNAc(2), producing Man(8)GlcNAc(2). In the ERQC, elevated enzyme concentrations allow further trimming to Man(5-6)GlcNAc(2). This enzymatic function is crucial for glycoprotein processing and quality control in the endoplasmic reticulum, ensuring proper folding and maturation. MAN1B1 Protein, Human (HEK293, His) is the recombinant human-derived MAN1B1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MAN1B1 Protein, Human (HEK293, His) is 594 a.a., with molecular weight of 58-80 kDa.

HY-P70891

	ERP27 Protein, Human (HEK293, His) Endoplasmic Reticulum Resident Protein 27; ER Protein 27; ERp27; ERP27; C12orf46	Human	HEK293
	The ERP27 protein has a unique role in that it can specifically bind unfolded proteins and recruit the protein disulfide isomerase PDIA3 to the substrate through the hydrophobic pocket in its C-terminal domain. This interaction implies that ERP27 is involved in the unfolding stress response and resolves challenges in cellular proteostasis. ERP27 Protein, Human (HEK293, His) is the recombinant human-derived ERP27 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ERP27 Protein, Human (HEK293, His) is 248 a.a., with molecular weight of 32-38 kDa.

HY-P70901

	TXNDC4 Protein, Human (HEK293, His) Thioredoxin domain-containing protein 4; ER protein 44; KIAA0573; TXNDC4	Human	HEK293
	The TXNDC4 protein is critical in cellular processes, mediating thiol-dependent retention in the early secretory pathway.Its conserved CRFS motif forms mixed disulfide bonds with substrate proteins to control oxidative protein folding in the endoplasmic reticulum and maintain cellular redox balance.TXNDC4 Protein, Human (HEK293, His) is the recombinant human-derived TXNDC4 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77087

	MMGT1 Protein, Human (HEK293, His) ER membrane protein complex subunit 5; Transmembrane protein 32; EMC5; TMEM32	Human	HEK293
	The MMGT1 protein is an important member of the endoplasmic reticulum membrane protein complex (EMC) and is essential for the independent insertion of newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. Its preference for transmembrane domains with weak hydrophobicity or unstable characteristics guides co- and post-translational insertion processes. MMGT1 Protein, Human (HEK293, His) is the recombinant human-derived MMGT1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P71046

	TXNDC12 Protein, Human (HEK293, His) Thioredoxin Domain-Containing Protein 12; Endoplasmic Reticulum Resident Protein 18; ER Protein 18; ERp18; Endoplasmic Reticulum Resident Protein 19; ER Protein 19; ERp19; Thioredoxin-Like Protein p19; hTLP19; TXNDC12; TLP19	Human	HEK293
	The TXNDC12 protein is an important endoplasmic reticulum-localized protein disulfide bond reductase that plays a key role in promoting disulfide bond formation in client proteins. As an essential component of cellular machinery, TXNDC12 contributes to complex protein folding processes, highlighting its importance in maintaining correct protein structure and function. TXNDC12 Protein, Human (HEK293, His) is the recombinant human-derived TXNDC12 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TXNDC12 Protein, Human (HEK293, His) is 142 a.a., with molecular weight of ~18.0 kDa.

HY-P76897

	EDEM2 Protein, Human (HEK293, His) ER degradation-enhancing alpha-mannosidase-like protein 2; C20orf31; C20orf49	Human	HEK293
	EDEM2 Protein is involved in the endoplasmic reticulum-associated degradation (ERAD) pathway. EDEM2 Protein, Human (HEK293, His) is the recombinant human-derived EDEM2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P71727

	CHGA Protein, Human (P.pastoris, His) beta Granin; catestatin; CgA; CHG A; ChromograninA; ER-37; SPI; vasostatin 2; Vasostatin; Vasostatin I; Vasostatin II; vasostatin-2	Human	P. pastoris
	CHGA protein robustly inhibits glucose-induced insulin release from the pancreas, functioning as a non-competitive nicotinic cholinergic antagonist. It inhibits catecholamine release, displays antibacterial activity, induces mast cell responses, and scavenges free radicals. CHGA may also regulate cardiac function and blood pressure. CHGA Protein, Human (P.pastoris, His) is the recombinant human-derived CHGA protein, expressed by P. pastoris , with N-His labeled tag. The total length of CHGA Protein, Human (P.pastoris, His) is 439 a.a., with molecular weight of ~50.9 kDa.

HY-P702352

	KDELR2 Protein, Mouse (Cell-Free, His) ER lumen protein-retaining receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2	Mouse	E. coli Cell-free
	KDELR2 Protein, a membrane receptor, crucially maintains endoplasmic reticulum (ER) resident proteins' localization. It binds the K-D-E-L sequence motif, retaining these proteins within the ER. This interaction facilitates vesicle-mediated recycling, ensuring proper subcellular localization through Golgi-to-ER protein return. KDELR2's pH-dependent binding, optimal at pH 5-5.4, underscores the regulatory role of pH in this vital cellular process. KDELR2 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived KDELR2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of KDELR2 Protein, Mouse (Cell-Free, His) is 212 a.a., with molecular weight of 26.0 kDa.

HY-P77342

	COX4NB Protein, Human (His) ER membrane protein complex subunit 8; Neighbor of COX4; C16orf2; COX4AL; COX4NB; FAM158B; NOC4	Human	E. coli
	COX4NB protein is a component of the endoplasmic reticulum membrane protein complex (EMC) and is able to insert newly synthesized membrane proteins into the endoplasmic reticulum membrane in an energy-independent manner. Its preference for transmembrane domains with weakly hydrophobic or unstable characteristics guides co- and post-translational insertion processes. COX4NB Protein, Human (His) is the recombinant human-derived COX4NB protein, expressed by E. coli , with N-His labeled tag. The total length of COX4NB Protein, Human (His) is 210 a.a., with molecular weight of ~27 kDa.

HY-P703180

	P2ER3 Protein, Human (Sf9, Flag, GFP, His) Prostaglandin E2 receptor EP3 subtype; PGE2-R; Prostanoid EP3 receptor; PTGER3; Homo sapiens; Human; PGE receptor EP3 subtype; G-protein coupled receptor; Receptor; TransducER	Human	Sf9 insect cells
	P2ER3 Protein, Human (Sf9, Flag, GFP, His) is the recombinant human-derived P2ER3, expressed by Sf9 insect cells , with His, GFP, Flag labeled tag. ,

HY-P71193

	PDIA6 Protein, Human (HEK293, His) Protein Disulfide-IsomERase A6; Endoplasmic Reticulum Protein 5; ER Protein 5; ERp5; Protein Disulfide IsomERase P5; Thioredoxin Domain-Containing Protein 7; PDIA6; ERP5; P5; TXNDC7	Human	HEK293
	PDIA6 protein has molecular chaperone activity, which can inhibit the aggregation of misfolded proteins and contribute to quality control. It negatively regulates the unfolded protein response (UPR) by binding to ERN1 and inhibiting its signaling. PDIA6 Protein, Human (HEK293, His) is the recombinant human-derived PDIA6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDIA6 Protein, Human (HEK293, His) is 421 a.a., with molecular weight of ~52.0 kDa.

HY-P71609

	TXNDC5 Protein, Human (GST) EndoPDI; Endoplasmic reticulum protein ERp46; Endoplasmic reticulum resident protein 46; Endothelial protein disulphide isomERase; ER protein 46; ERp46; Hcc 2; MGC3178; PDIA15; TLP46; TXND5_HUMAN; TXNDC 5; Txndc5	Human	E. coli
	TXNDC5 Protein, an endoplasmic reticulum lumen-based disulfide isomerase, crucially aids in forming disulfide bonds for protein stability and function. Its ability to reduce disulfide bonds in insulin highlights its role in intricate protein folding processes. TXNDC5's functional attributes make it a key player in preserving the structural integrity of endoplasmic reticulum proteins, contributing to cellular homeostasis. TXNDC5 Protein, Human (GST) is the recombinant human-derived TXNDC5 protein, expressed by E. coli , with N-GST labeled tag.

HY-P71917

	P4HB Protein, Human (His) Cellular thyroid hormone binding protein; Cellular thyroid hormone-binding protein; Collagen prolyl 4 hydroxylase beta; Disulphide IsomERase; DSI; EC 5.3.4.1; ER protein 59; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1_HUMAN; PDIR; PHDB; PO4DB; PO4HB; PROHB; Protocollagen hydroxylase; Thbp;	Human	E. coli
	The P4HB protein is a multifunctional entity that catalyzes disulfide bonding processes at the cell surface and within cells. As a reductase, it modifies outer surface proteins and participates in the formation of disulfide bonds in nascent proteins. P4HB Protein, Human (His) is the recombinant human-derived P4HB protein, expressed by E. coli , with N-6*His labeled tag. The total length of P4HB Protein, Human (His) is 490 a.a., with molecular weight of ~56 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-13636S

Fulvestrant-d3
Fulvestrant-d₃ is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].

HY-15654S

Phenylbutyrate-d11 sodium
Phenylbutyrate-d₁₁ (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[1].

HY-A0281S

4-Phenylbutyric acid-d11
4-Phenylbutyric acid-d₁₁ is the deuterium labeled 4-Phenylbutyric acid. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-19822S2

Elacestrant-d10
Elacestrant-d₁₀ is the deuterium labeled of Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also inhibits growth of ER ⁺ breast cancer cell lines in vitro and in vivo .

HY-19822S3

Elacestrant-d6
Elacestrant-d₆ (RAD1901-d₆) is a deuterated labeled Elacestrant (HY-19822). Elacestrant is a selective estrogen receptor (estrogen receptor, ER) degrader (SERD) with oral activity, with IC₅₀ values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-19822S

Elacestrant-d4
Elacestrant-d₄ (RAD1901-d₄) is a deuterated labeled Elacestrant (HY-19822). Elacestrant (RAD1901) is a selective estrogen receptor (estrogen receptor, ER) degrader (SERD) with oral activity, with IC₅₀ values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-19822S1

Elacestrant-d4-1
Elacestrant-d₄-1 is the deuterium labeled Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively .

HY-B0723S

Ospemifene D4
Ospemifene-d₄ is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active estrogen receptor modulator for the prevention of osteoporosis with IC50 values of 827 nM and 1633 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene has bone-sparing, antitumor, and cholesterol-lowering effects[1][2].

HY-A0031S

Bazedoxifene-d4

Bazedoxifene-d₄ is deuterium labeled Bazedoxifene. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

HY-A0031S2

Bazedoxifene-d4 acetate

Bazedoxifene-d₄ (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].

HY-19696S

Tauroursodeoxycholate-d5
Tauroursodeoxycholate-d₅ is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S1

Tauroursodeoxycholate-d4
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-B0141S

Estradiol-d3
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-19696AS

Tauroursodeoxycholate-d4 sodium
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S2

Tauroursodeoxycholate-d4-1
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-A0281S3

4-Phenylbutyric acid-d2
4-Phenylbutyric acid-d₂ is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

HY-B0141S1

Estradiol-d4 1 Publications Verification
Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S3

Estradiol-d2
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S2

Estradiol-d5
Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-A0281S2

4-Phenylbutyric acid-d5
4-Phenylbutyric acid-d₅ is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[2][3][4].

HY-N6710S

α-Zearalenol-d4
α-Zearalenol-d4 is a deuterated labeled α-Zearalenol . α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .

HY-50767S

Palbociclib-d8
Palbociclib-d₈ is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].

HY-50767S1

Palbociclib-d4 hydrochloride
Palbociclib-d₄ (hydrochloride) is the deuterium labeled Palbociclib hydrochloride. Palbociclib (PD 0332991) is a selective CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].

HY-B0141S4

Estradiol-13C6
Estradiol- ¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S5

Estradiol-13C2
Estradiol- ¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S6

Estradiol-d2-1
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3][4].

HY-12956S2

Dinoprost-13C5
Dinoprost- ¹³C₅ is ¹³C labeled Dinoprost (HY-12956). Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .

HY-Y1309S

1-Naphthol-d8
1-Naphthol-d₈ is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].

HY-Y1309S1

1-Naphthol-d7
1-Naphthol-d7 is the deuterium labeled Naphthol .

HY-N0492S

α-Lipoic Acid-d5
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80663

	Estrogen Receptor alpha Antibody ESR1; ERa; ERalpha; Estrogen receptor; Estradiol receptor; ER-alpha; Estrogen receptor 1; NR3A1; ER; ESR; ESRA; Estrogen receptor alpha	WB, IHC-F, IHC-P, ICC/IF, IP, ChIP	Human
	Estrogen Receptor alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 66 kDa, targeting to Estrogen Receptor alpha. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP,ChIP assays with tag free, in the background of Human.

HY-P80662

	Estrogen Receptor alpha Antibody (YA768) ESR1; ERa; ERalpha; Estrogen receptor; Estradiol receptor; ER-alpha; Estrogen receptor 1; NR3A1; ER; ESR; ESRA; Estrogen receptor alpha	WB	Human, Mouse, Rat
	Estrogen Receptor alpha Antibody (YA768) is a non-conjugated and Mouse origined monoclonal antibody about 66 kDa, targeting to Estrogen Receptor alpha (6F11). It can be used for WB assays with tag free, in the background of Transfected.

HY-P83691

	Eribulin Antibody ERibulin, B1939, E7389, ER-086526	ELISA	Human

HY-P82147

	Estrogen Receptor beta Antibody (YA1892) ESR2; ESTRB; NR3A2; Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A membER 2	WB, IHC-P	Human
	Estrogen Receptor beta Antibody (YA1892) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1892), targeting Estrogen Receptor beta, with a predicted molecular weight of 59 kDa (observed band size: 59 kDa). Estrogen Receptor beta Antibody (YA1892) can be used for WB, IHC-P experiment in human background.

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Cat. No.	Product Name		Classification

HY-162129

Antitumor agent-131		Azide
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC₅₀ value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .

HY-145273

EB-0150		Azide
EB-0150 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC₅₀s of 0.73 and 0.0337 μM, respectively. EB-0150 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0150 has the potential for the reseach of broad-spectrum agent against the existing and emerging viruses . EB-0150 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-139999

LCL-PEG3-N3		Azide
LCL-PEG3-N3 is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-139999A

LCL-PEG3-N3 hydrochloride		Azide
LCL-PEG3-N3 (hydrochloride) is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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