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click reaction

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982

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88

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20

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8

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1

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5

Isotope-Labeled Compounds

878

Click Chemistry

71

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-130544

    5-Azidovaleric acid

    Biochemical Assay Reagents Others
    5-Azidopentanoic acid (5-Azidovaleric acid) is a organic acid that can be used in click chemistry reactions .
    5-Azidopentanoic acid
  • HY-164209

    ADC Linker Others
    DBCO-PEG3-C1-acid is an antibody–drug conjugate (ADC) linker, which is used as a reaction handle for strain-promoted azide-alkyne click reaction .
    DBCO-PEG3-C1-acid
  • HY-D1593

    Fluorescent Dye Others
    BODIPY TMR-X alkyne, an orange-fluorescent dye, is an alkyne modified BODIPY TMR-X. BODIPY TMR-X alkyne can react with azides by the copper-catalyzed click reaction. BODIPY TMR-X alkyne is not sensitive to pH.
    BODIPY TMR-X alkyne
  • HY-D2289

    Fluorescent Dye Others
    CalFluor 647 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 647 azide is not fluorescent until it is reacted with alkynes .
    CalFluor 647 azide
  • HY-D2288

    Fluorescent Dye Others
    CalFluor 580 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 580 azide is not fluorescent until it is reacted with alkynes .
    CalFluor 580 azide
  • HY-151746

    ADC Linker Others
    N3-Gly-Gly-Gly-OH is a oligo-Gly click chemistry reagent containing an azide group. Oligo-Gly also has been used as linker to combine different subunits of dimeric or oligomeric proteins or to create artificial multi-domain proteins. By modification into Gly-Gly-Gly-Ser motifs high solubility can be achieved . N3-Gly-Gly-Gly-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-Gly-Gly-Gly-OH
  • HY-D1321

    Cyanine5 amine hydrochloride

    Fluorescent Dye Others
    Cyanine5 amine hydrochloride is a potent fluorescent dye. Cyanine5 amine hydrochloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λex=646 nm, λem=662 nm) .
    Cy 5 amine hydrochloride
  • HY-155685

    PROTACs VEGFR Ephrin Receptor Apoptosis Cancer
    SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase .
    SA-VA
  • HY-155684

    PROTACs VEGFR PDGFR Ephrin Receptor Cancer
    SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-PA is able to selectively degrade VEGFR-2, PDGFR-β and EphB4 proteins in U87 cells. SA-PA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues .
    SA-PA
  • HY-151766

    ADC Linker Others
    DACN(Tos,Suc-OH) is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Such strain-promoted azide-alkyne cycloadditions (SPAAC) using cycloalkynes have served for reliable molecular conjugation in a broad range of fields. The nitrogens are used as connection points for a variety of functional units. DACNs possess high thermal and chemical stability along with comparable click reactivity .
    DACN(Tos,Suc-OH)
  • HY-D1320

    Fluorescent Dye Others
    Cyanine5 azide chloride is a potent fluorescent dye. Cyanine5 azide chloride can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). (λex=646 nm, λem=662 nm) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Cyanine5 azide chloride
  • HY-157511

    E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .
    Thalidomide-O-C5-azide
  • HY-157510

    E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .
    Thalidomide-O-C3-azide
  • HY-157515

    E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .
    Thalidomide 4'-ether-PEG2-azide
  • HY-151742

    ADC Linker Others
    Norbornene-methyl-NHS is a click chemistry reagent containing a TCO group. Dienophile for conjugation via Diels-Alder-reaction, i.e. copper-free click reaction with tetrazines .
    Norbornene-methyl-NHS
  • HY-151730

    ADC Linker Others
    (Me)Tz-butanoic acid is a click chemistry reagent containing an azide. (Me)Tz-butanoic acid is tetrazine linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles . (Me)Tz-butanoic acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    (Me)Tz-butanoic acid
  • HY-151727

    ADC Linker Others
    Norbornene-NHS is a click chemistry reagent. Norbornene-NHS is a dienophile for conjugation via copper-free Click reaction with tetrazines .
    Norbornene-NHS
  • HY-W021042

    THPTA

    Biochemical Assay Reagents Others
    Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA) is an accelerating ligand in the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) and protects cells from oxidants generated by copper-catalyzed reduction of oxygen by ascorbate. In addition, Tris(3-hydroxypropyltriazolylmethyl)amine can also protect the histidine moiety of biomolecules in a manner proportional to the ligand concentration .
    Tris(3-hydroxypropyltriazolylmethyl)amine
  • HY-W800676

    Biochemical Assay Reagents Others
    DBCO-N-bis(PEG4-acid) is a branched click chemistry reagent. The DBCO group enables copper-free Click Chemistry reactions. carboxylic acid groups allows for reactions with primary amine groups using activators such as EDC or HATU to form a stable amide bond.
    DBCO-N-bis(PEG4-acid)
  • HY-151817

    Biochemical Assay Reagents Others
    5-Azidomethyl-uridine is a click chemistry reagent containing an azide group.The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction . 5-Azidomethyl-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5-Azidomethyl-uridine
  • HY-W800691

    Fluorescent Dye Others
    BP Fluor 350 Picolyl Azide is a blue-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
    BP Fluor 350 picolyl azide
  • HY-151745

    ADC Linker Others
    N3-TOTA-Suc is a click chemistry reagent containing an azide group. Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments . N3-TOTA-Suc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-TOTA-Suc
  • HY-D1625

    Fluorescent Dye Others
    Cy5 DBCO chloride is an azide reaction probe and the addition of DBCO molecules allows the imaging of azide-labelled biomolecules by a copper-free “Click Chemistry” reaction . Cy5 DBCO (chloride) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Cy5 DBCO chloride
  • HY-151749

    ADC Linker Others
    N3-D-Lys(Fmoc)-OH is a click chemistry reagent containing an azide group. Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments . N3-D-Lys(Fmoc)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-D-Lys(Fmoc)-OH
  • HY-151736

    ADC Linker Others
    N3-L-Dap(Boc)-OH is a click chemistry reagent containing an azide group. Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments . N3-L-Dap(Boc)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-L-Dap(Boc)-OH
  • HY-151796

    ADC Linker Others
    DACN(Ms,Ns) is a click chemistry reagent containing a cyclic alkyne group .
    DACN(Ms,Ns)
  • HY-127112

    Cytochrome P450 Others
    Oleic acid alkyne is oleic acid with an acetylene group. The terminal alkyne group can be used for click chemical ligation reactions. Oleic acid can be hydroxylated by a microsomal cytochrome P-450-dependent system (ω-OAH). Through click chemistry reactions, fluorescent or biotin-labeled oleic acid can be introduced to analyze its metabolism and biological activity.
    Oleic acid alkyne
  • HY-D2769

    Difluorocarboxyfluorescein azide, 6-isomer

    Biochemical Assay Reagents Others
    Oregon green 488 azide (Difluorocarboxyfluorescein azide, 6-isomer) is a bright, green-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
    Oregon green 488 azide
  • HY-151682

    ADC Linker Others
    H-L-Lys(Norbornene-methoxycarbonyl)-OH, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH can be used for the mild and selective modification of proteins in a copper-free click reaction .
    H-L-Lys(Norbornene-methoxycarbonyl)-OH
  • HY-151682A

    ADC Linker Others
    H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride, a norbornene-derivatized lysine, can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride can be used for the mild and selective modification of proteins in a copper-free click reaction .
    H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride
  • HY-156488

    Biochemical Assay Reagents Others
    TCO-PEG7-Maleimide contains TCO groups, and can undergo specific "click" reactions with tetrazine groups.
    TCO-PEG7-Maleimide
  • HY-151685

    ADC Linker Others
    Kdo Azide is a click chemistry reagent containing an azide. Kdo Azide is a metabolic labeling reagent . Kdo Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Kdo Azide
  • HY-151844

    ADC Linker Others
    2-Azido-adenosine is a click chemistry reagent containing an azide group . 2-Azido-adenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2-Azido-adenosine
  • HY-151669

    ADC Linker Others
    Fmoc-D-Aha-OH is a click chemistry reagent containing an azide . Fmoc-D-Aha-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fmoc-D-Aha-OH
  • HY-151840

    ADC Linker Others
    4-Azidobenzyl alcohol is a click chemistry reagent containing an azide group . 4-Azidobenzyl alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    4-Azidobenzyl alcohol
  • HY-148880

    Biochemical Assay Reagents Others
    VHLL-BCN can improve the efficiency of click chemistry reaction. VHLL-BCN can be used for the development of transcription factor (TF)-PROTAC .
    VHLL-BCN
  • HY-151842

    ADC Linker Others
    Fmoc-EDA-N3 is a click chemistry reagent containing an azide group . Fmoc-EDA-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fmoc-EDA-N3
  • HY-151666

    ADC Linker Others
    6-Azido-D-lysine is a click chemistry reagent containing an azide . 6-Azido-D-lysine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    6-Azido-D-lysine
  • HY-151666A

    ADC Linker Others
    6-Azido-D-lysine hydrochloride is a click chemistry reagent containing an azide . 6-Azido-D-lysine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    6-Azido-D-lysine hydrochloride
  • HY-D2759

    Fluorescent Dye Others
    Cyanine3B azide for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. Cyanine3B is a yellow-emitting cyanine dye that is an improved version of the Cyanine3 fluorophore with significantly higher fluorescence quantum yield and photostability. Due to the fixed conformation, Cyanine3B has the highest emission quantum yield compared to other dyes of this wavelength. This is a non-sulfonated dye that requires an organic co-solvent (DMF, DMSO, or other) for efficient labeling in water.
    Cyanine3B azide
  • HY-D2200

    Fluorescent Dye Others
    Cy5.5(Me)-C3-DBCO is a click chemistry reagent containing an cycloalkynes group. DBCO group enables copper free biocompatible click chemistry with fast reaction kinetics and good stability .
    Cy5.5(Me)-C3-DBCO
  • HY-151698

    ADC Linker Others
    TCO-NHS Ester axial is a click chemistry reagent that can be used as a building block in amine reactions. TCO-NHS Ester axial contains TCO groups, which can undergo inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-NHS Ester (axial)
  • HY-W763598B

    Biochemical Assay Reagents Others
    Poly(ethylene glycol) distearate (Mn 930) is a derivative of polyethylene glycol, which can be used as a cross-linking agent and click chemistry reaction .
    Polyethylene glycol distearate (Mn 930)
  • HY-W190911

    Biochemical Assay Reagents Others
    Cyclooct-4-en-1-yl(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate is commonly used in Click Chemistry reactions. The hydroxyl group allows for additional reactions to take place to further derivatize the compound.
    Cyclooct-4-en-1-yl(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate
  • HY-169980

    Epigenetic Reader Domain Ligands for Target Protein for PROTAC Cancer
    Mivebresib-alkyne (Compound 25), a Mivebresib (HY-100015) derivative, can be used for BRD4 targeted PROTAC synthesis through click reaction .
    Mivebresib-alkyne
  • HY-172355

    Biochemical Assay Reagents Others
    Azide-PEG-NHS (Mn 3500) is an azide PEG NHS ester that can be used for click chemistry reactions and can also be used to synthesize PEG hydrogels .
    Azide-PEG-NHS (MW 3500)
  • HY-W749169

    Fluorescent Dye Others
    FAM tetrazine, 5-isomer is a universal dye that has terminal tetrazine group. The terminal methyltetrazine enables fast click reactions with TCO (trans-cycloctene).
    FAM tetrazine, 5-isomer
  • HY-172355A

    Biochemical Assay Reagents Others
    Azide-PEG-NHS (Mn 5000) is an azide PEG NHS ester that can be used for click chemistry reactions and can also be used to synthesize PEG hydrogels .
    Azide-PEG-NHS (MW 5000)
  • HY-W800725

    Biochemical Assay Reagents Others
    m-PEG2-DBCO is a monodisperse PEG reagents which can enable copper-free Click Chemistry through the reaction of DBCO with azide.
    m-PEG2-DBCO
  • HY-151816

    ADC Linker Others
    alpha-Man-TEG-N3 is a click chemistry reagent containing an azide group . alpha-Man-TEG-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    alpha-Man-TEG-N3

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