Search Result

Results for "

neutrophil

" in MedChemExpress (MCE) Product Catalog:

By Targets:	15-PGDH (1) 5-HT Receptor (2) ADC Cytotoxin (4) Adenosine Receptor (2) Akt (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (17) Apoptosis (11) Aryl Hydrocarbon Receptor (1) Autophagy (9) Bacterial (31) Biochemical Assay Reagents (3) Bombesin Receptor (1) Btk (1) c-Fms (2) Calcium Channel (2) Caspase (4) Cathepsin (5) CCR (1) Complement System (14) CXCR (16) Cytochrome P450 (2) Drug Metabolite (3) EGFR (1) Elastase (36) Endogenous Metabolite (16) Epoxide Hydrolase (3) ERK (3) FLAP (2) Formyl Peptide Receptor (FPR) (8) Free Fatty Acid Receptor (2) Fungal (7) Furin (1) G Protein-coupled Receptor Kinase (GRK) (1) Glucocorticoid Receptor (9) GPR84 (1) HCV (1) HDAC (2) Histamine Receptor (1) HIV (1) HSV (1) HuR (1) IKK (3) Integrin (2) Interleukin Related (8) Isotope-Labeled Compounds (5) JNK (1) Leukotriene Receptor (12) Lipase (1) Lipoxygenase (7) LPL Receptor (1) MicroRNA (3) Mitophagy (9) Na+/K+ ATPase (1) NF-κB (4) NO Synthase (3) NOD-like Receptor (NLR) (2) P-selectin (2) P2Y Receptor (1) p38 MAPK (3) Parasite (5) PD-1/PD-L1 (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phospholipase (4) PI3K (2) PKA (4) PKC (3) Platelet-activating Factor Receptor (PAFR) (1) Protease Activated Receptor (PAR) (3) Proteasome (2) Protein Arginine Deiminase (8) Pyroptosis (1) RAR/RXR (1) Ras (2) Reactive Oxygen Species (6) ROCK (1) SARS-CoV (14) Ser/Thr Protease (4) SGK (1) Src (3) STAT (1) Syk (3) Tau Protein (1) TGF-β Receptor (3) Thrombin (1) TNF Receptor (4) Toll-like Receptor (TLR) (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (59) Cardiovascular Disease (17) Endocrinology (12) Infection (39) Inflammation/Immunology (188) Metabolic Disease (18) Neurological Disease (14)

By Targets:

15-PGDH (1)

5-HT Receptor (2)

ADC Cytotoxin (4)

Adenosine Receptor (2)

Akt (3)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (17)

Apoptosis (11)

Aryl Hydrocarbon Receptor (1)

Autophagy (9)

Bacterial (31)

Biochemical Assay Reagents (3)

Bombesin Receptor (1)

Btk (1)

c-Fms (2)

Calcium Channel (2)

Caspase (4)

Cathepsin (5)

CCR (1)

Complement System (14)

CXCR (16)

Cytochrome P450 (2)

Drug Metabolite (3)

EGFR (1)

Elastase (36)

Endogenous Metabolite (16)

Epoxide Hydrolase (3)

ERK (3)

FLAP (2)

Formyl Peptide Receptor (FPR) (8)

Free Fatty Acid Receptor (2)

Fungal (7)

Furin (1)

G Protein-coupled Receptor Kinase (GRK) (1)

Glucocorticoid Receptor (9)

GPR84 (1)

HCV (1)

HDAC (2)

Histamine Receptor (1)

HIV (1)

HSV (1)

HuR (1)

IKK (3)

Integrin (2)

Interleukin Related (8)

Isotope-Labeled Compounds (5)

JNK (1)

Leukotriene Receptor (12)

Lipase (1)

Lipoxygenase (7)

LPL Receptor (1)

MicroRNA (3)

Mitophagy (9)

Na+/K+ ATPase (1)

NF-κB (4)

NO Synthase (3)

NOD-like Receptor (NLR) (2)

P-selectin (2)

P2Y Receptor (1)

p38 MAPK (3)

Parasite (5)

PD-1/PD-L1 (1)

Phosphatase (1)

Phosphodiesterase (PDE) (1)

Phospholipase (4)

PI3K (2)

PKA (4)

PKC (3)

Platelet-activating Factor Receptor (PAFR) (1)

Protease Activated Receptor (PAR) (3)

Proteasome (2)

Protein Arginine Deiminase (8)

Pyroptosis (1)

RAR/RXR (1)

Ras (2)

Reactive Oxygen Species (6)

ROCK (1)

SARS-CoV (14)

Ser/Thr Protease (4)

SGK (1)

Src (3)

STAT (1)

Syk (3)

Tau Protein (1)

TGF-β Receptor (3)

Thrombin (1)

TNF Receptor (4)

Toll-like Receptor (TLR) (1)

Xanthine Oxidase (1)

By Research Areas:

Cancer (59)

Cardiovascular Disease (17)

Endocrinology (12)

Infection (39)

Inflammation/Immunology (188)

Metabolic Disease (18)

Neurological Disease (14)

270

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70227

Cathepsin G, human neutrophils CTSH; ACC4; ACC5	Others	Inflammation/Immunology
Cathepsin G, human neutrophils (CTSH; ACC4) a serine protease found in polymorphonuclear neutrophils (PMNs), functions in inflammation .

HY-155414

Neutrophil elastase inhibitor 5	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC₅₀ values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases .

HY-163411

Neutrophil elastase inhibitor 6	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 6 (compound 113) is an irreversible phosphonic-type inhibitor of human neutrophil elastase .

HY-132132

Neutrophil elastase inhibitor 3	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC₅₀ of 80.8 nM for NE release .

HY-118177

Neutrophil elastase inhibitor 1	Elastase Thrombin Ser/Thr Protease	Inflammation/Immunology Cancer
Neutrophil elastase inhibitor 1 (Compound 5b) is a competitive, pseudoirreversible inhibitor for neutrophil elastase with an IC₅₀ of 7 nM .

HY-155231

Neutrophil elastase inhibitor 4	Elastase	Cancer
Neutrophil elastase inhibitor 4 (compound 4f) is a competitive *human neutrophil* elastase (HNE) inhibitor (IC₅₀: 42.30 nM, K_i*: 8.04 nM). Neutrophil* elastase inhibitor 4 induces T47D cell apoptosis. Neutrophil elastase inhibitor 4 inhibits cell proliferation with IC₅₀s of 21.25, 34.17, 29.93, 99.11 nM for T47D, RPMI 8226, A549, and HSF cells .

HY-E70356

Neutrophil Elastase (NEG),Human ELA-2, Elastase, hne, leukocyte elastase, serine elastase, elaszym	Others	Others
Neutrophil Elastase (NEG), Human (ELA-2, Elastase, hne, leukocyte elastase, serine elastase, elaszym) is a biological material or organic compound that can be used in life science research .

HY-P5631

*Rabbit neutrophil* peptide 3b**	Bacterial	Infection
Rabbit neutrophil peptide 3b is an antimicrobial peptide derived from rabbit peritoneal neutrophils .

HY-P5603

*Bovine neutrophil* beta-defensin 12** BNBD-12	Bacterial	Infection
Bovine neutrophil beta-defensin 12 is an antimicrobial peptide derived from bovine neutrophils, which has antibacterial activity against Escherichia coli and Staphylococcus aureus .

HY-P1068B

Lysozyme, Human Neutrophil	Others	Infection
Lysozyme, Human Neutrophil is found to be present in all three types of human neutrophil granules (azurophil-, specific- and gelatinase granules). Lysozyme, Human Neutrophil takes part in antibacterial activity of leukocytes .

HY-D2310

CXCR2 Probe 1	CXCR	Inflammation/Immunology
CXCR2 Probe 1 (Compound ^[18F]16b) is a selective ligand for CXCR2 and is a radiotracer for PET imaging of neutrophils in inflammatory diseases .

HY-117668

MDL 101146	Elastase	Infection Inflammation/Immunology
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a K_i value of 25 nM. MDL 101146 can be used for the research of arthritis .

HY-112742

CP-195543	Leukotriene Receptor	Inflammation/Immunology
CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC₅₀s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration .

HY-126822

MDL27324	Elastase	Others
MDL27324 is an inhibitor of neutrophil proteases. MDL27324 can be taken up by the cell and has a modest inhibitory effect on the proteolysis of ingested fluoresceinated immune complexes (200 μM, 20% inhibition) .

HY-113442A

6-trans-Leukotriene B4	Others	Inflammation/Immunology
6-trans-leukotriene B4 is a neutrophil chemotaxin in the guinea pig dermis .

HY-123753

MDL 27399	Cathepsin	Inflammation/Immunology
MDL 27399 is an inhibitor of human neutrophil cathepsin G (K_i = 7 μM). MDL 27399 can be used for research of inflammatory diseases .

HY-162168

Anti-inflammatory agent 71	Others	Inflammation/Immunology
Anti-inflammatory agent 71 (Compound 3.2) is an anti-inflammatory agent that can reduce the levels of neutrophils, COX-2, nitrotyrosine, IL-1b, and C-reactive protein, while increasing the level of eNOS .

HY-130497

12-Oxo-leukotriene B4 12-Oxo-LTB4	Endogenous Metabolite	Inflammation/Immunology
12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590) metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions . 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC₅₀ of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC₅₀ of 170 nM .

HY-N3566

Cepharadione A	Others	Inflammation/Immunology
Cepharadione A can be isolated from the roots of Piper betle Linn. Cepharadione A inhibits FMLP/CB induced elastase release by human neutrophils .

HY-P0261A

Indolicidin acetate	Bacterial	Infection
Indolicidin acetate is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils .

HY-P0261B

Indolicidin TFA	Bacterial	Infection
Indolicidin TFA is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils .

HY-116444

16(S)-HETE	Others	Neurological Disease
16(S)-HETE is an endogenous inhibitor of neutrophil activity and can be used in the study of acute ischemic brain injury .

HY-122161

JNJ-10311795 RWJ-355871	Cathepsin	Inflammation/Immunology
JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (K_i = 38 nM) and mast cell chymase (K_i = 2.3 nM), exhibits noteworthy antiinflammatory activity .

HY-120333

Antibiotic PF 1052	Antibiotic Fungal Bacterial	Infection
Antibiotic PF 1052 is an antibiotic extracted from a natural product library. Antibiotic PF 1052 has an inhibitory effect on murine neutrophil migration .

HY-50688

SB-265610 2 Publications Verification	CXCR	Inflammation/Immunology
SB-265610 is a selective, competitive, nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis with IC₅₀s of 3.7 nM and 70 nM, respectively .

HY-P3648

Ala-Ala-Pro-Val-chloromethylketone AAPV-CMK	Elastase	Inflammation/Immunology
Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases .

HY-15651A

Alvelestat tosylate AZD9668 tosylate	Elastase	Inflammation/Immunology
Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC₅₀ value of 7.9 nM, a K_i value of 9.4 nM and a K_d value of 9.5 nM .

HY-P5459

Elafin(human)	Bacterial Elastase	Infection
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus .

HY-P1118

Ac9-25	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-P1291

PKI 14-22 amide,myristoylated 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-125567

Antileukinate	CXCR	Inflammation/Immunology
Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury .

HY-103472

FPR-A14	Formyl Peptide Receptor (FPR)	Neurological Disease
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca ²⁺ mobilization and chemotaxis with EC₅₀s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation .

HY-106216

Tiprelestat	Elastase	Infection Inflammation/Immunology
Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease .

HY-P1118A

Ac9-25 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-149589

11(Z),14(Z)-Eicosadienoic acid	Leukotriene Receptor	Inflammation/Immunology
11(Z),14(Z)-Eicosadienoic acid is a unsaturated fattly acid that inhibits [ ³H] leukotriene B₄ (LTB₄) binding to pig neutrophil membranes with a K_i of 3 μM. 11(Z),14(Z)-Eicosadienoic acid has inflammatory activities .

HY-P1291A

PKI 14-22 amide,myristoylated TFA 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated TFA is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated TFA reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-125792

Nexinhib20	Reactive Oxygen Species Ras	Inflammation/Immunology
Nexinhib20 is a specific Rab27a-JFC1 interaction inhibitor with a calculated IC₅₀ of 2.6 μM. Nexinhib20 significantly inhibits superoxide anion production. Nexinhib20 efficiently decreases exocytosis of azurophilic granules in neutrophils stimulated with fMLP, GM-CSF or both. Nexinhib20 has a significant anti-inflammatory activity .

HY-139874

CXCR2 antagonist 3	CXCR	Inflammation/Immunology Cancer
CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3 ⁺ T lymphocytes into the Pan02 tumor tissues .

HY-147140

BOS-318	Furin	Inflammation/Immunology
BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC₅₀ value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease .

HY-P10724

fMIFL	Formyl Peptide Receptor (FPR) Bacterial	Infection
fMIFL is an FPR1 agonist. fMIFL can activate several signaling pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, secretion of granule exocytosis, and the production of superoxide anions. fMIFL can be used in research on bacterial infections and tissue damage .

HY-16992A

W-54011 5 Publications Verification	Complement System Reactive Oxygen Species	Inflammation/Immunology
W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of ¹²⁵I-labeled C5a to human neutrophils with a K_i value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca ²⁺ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC₅₀s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively .

HY-122767

Romurtide Muroctasin	Interleukin Related	Inflammation/Immunology
Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), IL-1 and IL-6 in vitro .

HY-113434A

5(R)-HETE	Others	Inflammation/Immunology
5(R)-HETE is a lipoxygenase product of arachidonic acid. 5(R)-HETE is an? inducer of neutrophil migration through endothelial and epithelial barriers. 5(R)-HETE is important in mediating lung inflammatory processes .

HY-124061

GB83	Protease Activated Receptor (PAR)	Neurological Disease Inflammation/Immunology
GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons .

HY-N7032

Uridine 5′-diphosphoglucose disodium salt 5 Publications Verification UDP-D-Glucose disodium salt	Endogenous Metabolite P2Y Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Uridine 5’-diphosphoglucose (UDP-glucose) disodium salt, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium salt is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium salt is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

HY-163379

C5aR1 antagonist 2	Complement System	Inflammation/Immunology
C5aR1 antagonist 2 (Compound 6a) is an orally active C5a receptor 1 (C5aR1) antagonist that shows efficacy in inhibiting the C5a-induced neutrophil count increase. C5aR1 antagonist 2 is potent in the DISCO and migration assays, with IC₅₀ values of 21 and 3 nM, respectively. C5aR1 antagonist 2 can be used for the research of acute and chronic inflammatory diseases .

HY-N7885

(25R)-Spirost-4-ene-3,12-dione (-)-(25R)-Spirost-4-ene-3,12-dione	Others	Inflammation/Immunology
(25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells .

HY-122011

PF-4950834	ROCK SGK PKA PKC	Inflammation/Immunology
PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC₅₀ values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration .

HY-164502

NAP1051	Akt	Cancer
NAP1051 is a biomimetic analog of lipin A4 that achieves anti-tumor effects by targeting the inflammatory tumor microenvironment. NAP1051 inhibits neutrophil chemotaxis to fMLP and stimulates macrophage efferocytosis by activating AKT. NAP1051 can be used in colorectal cancer research .

HY-143563

NLRP3 antagonist 1	NOD-like Receptor (NLR)	Cancer
NLRP3 antagonist 1 is a potent antagonist of NLRP3. NLRP3 is mainly expressed in macrophages and neutrophils and is involved in the body's intrinsic immunity against pathogenic infections and stress injury. NLRP3 antagonist 1 has the potential for the research of cancer disease (extracted from patent WO2021114691A1, compound 3) .

Cat. No.	Product Name	Type

HY-10475G

AM580 (GMP) CD336 (GMP); NSC608001 (GMP); Ro 40-6055 (GMP)	Fluorescent Dye
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

HY-D2310

CXCR2 Probe 1	Dyes
CXCR2 Probe 1 (Compound ^[18F]16b) is a selective ligand for CXCR2 and is a radiotracer for PET imaging of neutrophils in inflammatory diseases .

Cat. No.	Product Name	Type

HY-P3161

Lactoferrin

Native Proteins

Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin has anti-inflammatory, immunomodulatory, and anti-cancer activities .

HY-113058

3-Hydroxyoctanoic acid

Biochemical Assay Reagents

3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.

HY-158226

Elastin Methacrylated

ElaMA

3D Bioprinting

Elastin Methacrylated (ElaMA) elastin recruits and modulates innate immune cells and accelerates angiogenesis at the wound site, thereby improving wound regeneration. Elastin Methacrylated attracts large numbers of neutrophils and primarily M2 macrophages to the wound and induces their penetration into the hydrogel. Elastin Methacrylated has excellent immunomodulatory effects, leading to superior angiogenesis, collagen deposition and dermal regeneration . Elastin Methacrylated needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.

HY-10475G

AM580 (GMP) CD336 (GMP); NSC608001 (GMP); Ro 40-6055 (GMP)	Biochemical Assay Reagents
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

HY-115369

Methyl (13Z,16Z,19Z)-docosatrienoate

Drug Delivery

cis-13,16,19-Docosatrienoic acid methyl ester is an ester form of docosatrienoic acid, a rare omega-3 fatty acid not found in the normal phospholipid polyunsaturated fatty acid pool Easily detectable, it inhibits the binding of [3H]-LTB4 to porcine neutrophils at a concentration of 5 μM. Methyl docosatrienoate is more fat-soluble than the free acid and may be more desirable than the free acid in some formulations.

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Cat. No.	Product Name	Target	Research Area

HY-P4486

H-Pro-Gly-Pro-OH	Peptides	Others
H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia .

HY-P0261A

Indolicidin acetate	Bacterial	Infection
Indolicidin acetate is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils .

HY-P1118

Ac9-25	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-P1291

PKI 14-22 amide,myristoylated 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-P5631

*Rabbit neutrophil* peptide 3b**	Bacterial	Infection
Rabbit neutrophil peptide 3b is an antimicrobial peptide derived from rabbit peritoneal neutrophils .

HY-P5603

*Bovine neutrophil* beta-defensin 12** BNBD-12	Bacterial	Infection
Bovine neutrophil beta-defensin 12 is an antimicrobial peptide derived from bovine neutrophils, which has antibacterial activity against Escherichia coli and Staphylococcus aureus .

HY-P0261B

Indolicidin TFA	Bacterial	Infection
Indolicidin TFA is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils .

HY-P3648

Ala-Ala-Pro-Val-chloromethylketone AAPV-CMK	Elastase	Inflammation/Immunology
Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases .

HY-P5459

Elafin(human)	Bacterial Elastase	Infection
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus .

HY-125567

Antileukinate	CXCR	Inflammation/Immunology
Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury .

HY-106216

Tiprelestat	Elastase	Infection Inflammation/Immunology
Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease .

HY-P1118A

Ac9-25 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-P1291A

PKI 14-22 amide,myristoylated TFA 1 Publications Verification	PKA	Cancer
PKI 14-22 amide,myristoylated TFA is a potent cAMP-dependent PKA inhibitor. PKI 14-22 amide,myristoylated TFA reduces the IgG-mediated phagocytic response and also inhibits neutrophil adhesion .

HY-P10724

fMIFL	Formyl Peptide Receptor (FPR) Bacterial	Infection
fMIFL is an FPR1 agonist. fMIFL can activate several signaling pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, secretion of granule exocytosis, and the production of superoxide anions. fMIFL can be used in research on bacterial infections and tissue damage .

HY-122767

Romurtide Muroctasin	Interleukin Related	Inflammation/Immunology
Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), IL-1 and IL-6 in vitro .

HY-P2294

pm26TGF-β1 peptide	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P2294A

pm26TGF-β1 peptide TFA 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P1099

Ac2-12 1 Publications Verification	Peptides	Inflammation/Immunology
Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models .

HY-P5995

MeOSuc-AAPA-CMK	Elastase	Cancer
MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase .

HY-P1099A

Ac2-12 TFA	Peptides	Inflammation/Immunology
Ac2-12 TFA, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 TFA has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models .

HY-P0261

Indolicidin	Bacterial	Infection
Indolicidin is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils.

HY-P1756

N-Formyl-Met-Ala-Ser	Peptides	Inflammation/Immunology
N-Formyl-Met-Ala-Ser is a peptide, binds to formyl peptide receptors on neutrophils.

HY-P2311

Defensin HNP-2 human	Endogenous Metabolite Antibiotic	Inflammation/Immunology
Defensin HNP-2 human is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils.

HY-103544

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P	JNK Interleukin Related Bombesin Receptor	Inflammation/Immunology Cancer
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca ²⁺ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer

HY-P5374

MeOSuc-AAPV-AFC	Peptides	Others
MeOSuc-AAPV-AFC is a biological active peptide. (A highly specific neutrophil elastase substrate, Abs/Em=380/500 nm.)

HY-P10629

PSMα2	Peptides	Inflammation/Immunology
PSMα2 is a potent PSM (phenol-soluble modulin) peptide toward mouse neutrophils, led to strong influx of leukocytes .

HY-P3293

Lonodelestat POL6014	Elastase	Inflammation/Immunology
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of *human neutrophil* elastase (hNE)**. Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) .

HY-P5923

E70K	CXCR	Inflammation/Immunology
E70K is a CXCL8 C-terminal peptide with a substitution of glutamic acid (E) 70 with lysine (K). E70K can reduce neutrophil adhesion and migration during inflammation .

HY-P3293A

Lonodelestat TFA POL6014 TFA	Elastase	Inflammation/Immunology
Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of *human neutrophil* elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF) .**

HY-P4663

Val-Gly-Ser-Glu NSC 350591	Peptides	Cancer
Val-Gly-Ser-Glu (NSC 350591) is an ECF-A tetrapeptide. Val-Gly-Ser-Glu dose-dependently increases the number of human eosinophils, but not neutrophils, rosetting with complement-coated sheep erythrocytes (EAC3b) .

HY-P3361

IDR-1018	Parasite Bacterial Antibiotic	Infection Inflammation/Immunology
IDR-1018 is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epidermidis ATCC14990. IDR-1018 can be used to synthesis V-IDR1018 (vancomycin-innate defense regulator conjugate) .

HY-P2310

Defensin HNP-1 human	Bacterial Parasite	Infection Cardiovascular Disease
Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human exhibits broad antimicrobial and anti-leishmanial activities .

HY-P2642

Peptide 78	Peptides	Inflammation/Immunology
Peptide 78, a chemotactic cytokine, a 78 amino acid protein member of the IL-8 or C-X-C chemokine supergene family. ENA-78 plays an important role in the elicitation of predominantly neutrophils (PMNs) into the joints of rheumatoid arthritis (RA) .

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite	Infection Cardiovascular Disease
Defensin HNP-1 human TFA is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human TFA exhibits broad antimicrobial and anti-leishmanial activities .

HY-P0308

[Glu1]-Fibrinopeptide B	Peptides	Cardiovascular Disease
[Glu1]-Fibrinopeptide B is derived from fibrinopeptide B amino acid residues 1-14. Human fibrinopeptide B (hFpB), a thrombin-derived proteolytic cleavage product of the fibrinogen B beta-chain, to stimulate neutrophils (PMN), monocytes, and fibroblasts.

HY-P1508

Bactenecin Bactenecin, bovine	Bacterial Fungal Antibiotic	Infection
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-P1508A

Bactenecin TFA Bactenecin, bovine TFA	Bacterial Fungal	Infection
Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-W014049

N'-Nitro-D-arginine	NO Synthase	Others
N'-Nitro-D-arginine, a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) .

HY-P1405

Pam3CSK4-Biotin Pam3Cys-Ser-(Lys)4-Biotin	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist .

HY-P2573

Suc-AAPF-pNA Suc-Ala-Ala-Pro-Phe-pNA	Peptides	Others
Suc-AAPF-pNA (Suc-Ala-Ala-Pro-Phe-pNA) is a chromogenic p-nitroanilide (pNA) substrate with the K_m of 1.7 mM. Cleavage of Suc-AAPF-pNA releases 4-nitroaniline, which is yellow in colour and can be measured spectrophotometrically. Suc-AAPF-pNA can be used for the measurement of free and membrane-bound cathepsin G in human neutrophils .

HY-P1119

WRW4 4 Publications Verification	Formyl Peptide Receptor (FPR)	Neurological Disease
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC₅₀ of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide .

HY-P3012

Cathepsin G	Cathepsin	Inflammation/Immunology
Cathepsin G acts as a potent agonist of human platelet activation leading to their aggregation., and can be used for screening of relevant inhibitors .

HY-P1640

(Trp63,Trp64)-C3a(63-77)	Complement System	Inflammation/Immunology
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca ²⁺ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC₅₀ of 9.5, 2.0 and 0.8 nM, respectively .

HY-P5413

[Lys3]-Bombesin	Peptides	Others
[Lys3]-Bombesin is a biological active peptide. (PET (Positron Emission Tomography) imaging of [Lys3]-bombesin is able to detect gastrin-releasing peptide receptor (GRPR) positive prostate cancer. An immunoconjugate of [Lys3]-bombesin and corresponding monoclonal antibody can specifically induce (CD64)-dependent monocyte and neutrophil-mediated lysis of small cell carcinoma.)

HY-P5483

Retro-indolicidin	Bacterial	Others
Retro-indolicidin is a biological active peptide. (Reverse peptide of indolicidin (Rev4) is a 13-amino acid residue peptide based on the sequence of indolicidin. Indolicidin, a member of the cathelicidin protein family, is a 13-amino acid residue cationic, antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils. The synthetic peptide Rev4 has been shown to possess strong antimicrobial as well as protease inhibitory activities in vitro.)

HY-P10300

CXCL8 (54-72) IL-8 (54-72)	Peptides	Inflammation/Immunology
CXCL8 (54-72) is a C-terminal peptide based on the chemokine CXCL8. CXCL8 (54-72) has an interaction between a long and highly positively charged C-terminal region and a negative charge on the GAG that binds to the GAG. CXCL8 (54-72) can inhibit the adhesion and migration of neutrophils and adhesion of endothelial cells. CXCL8 (54-72) can be used to study chemokines in inflammatory response .

HY-P10552

pCXCL8-1aa	CXCR	Inflammation/Immunology
pCXCL8-1aa is an anti-inflammatory peptide. pCXCL8-1aa competitively inhibits the binding of CXCL8 to glycosaminoglycans such as heparin sulfate (HS) by binding with high affinity. This reduces the presentation of CXCL8 on the surface of vascular endothelial cells, thereby inhibiting neutrophil migration and inflammatory responses. pCXCL8-1aa can be used to study inflammatory diseases such as rheumatoid arthritis .

HY-P3214

Myosin light chain kinase fragment 11-19 amide MLCK(11-19) amide	Peptides	Cancer
Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. Myosin light chain kinase fragment 11-19 amide inhibits hypotonicity-induced Ca ²⁺ entry. Myosin light chain kinase fragment 11-19 amide can be used in the research of human cervical cancer .

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

HY-P0172A

ATI-2341 TFA 2 Publications Verification	CXCR	Inflammation/Immunology Endocrinology Cancer
ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) .

Cat. No.	Product Name	Target	Research Area

HY-P99440

Anumigilimab CSL-324	c-Fms	Inflammation/Immunology
Anumigilimab (CSL-324) is an human IgG4 mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation .

HY-P99443

Aselizumab HuDreg-55	Inhibitory Antibodies	Inflammation/Immunology
Aselizumab (HuDreg-55) is an humanized IgG4 mAb against L-selectin. However, L-selectin (CD62L) is a cell adhesion molecule expressed on circulating neutrophils. It regulates migrating cells to chemotaxis towards the site of injury. Aselizumab may be account for a high rate of infections and leucopenia after truma .

HY-P99396

Spesolimab BI 655130	Interleukin Related	Inflammation/Immunology
Spesolimab (BI 655130) is a mouse-derived humanized IgG1k antibody against IL-36R. IL-36 plays an important role in the immune system and Spesolimab is being investigated in palmoplantar pustulosis (PPP). Spesolimab was associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways .

HY-P99520

Vilobelimab CaCP-29, IFX-1	Complement System SARS-CoV	Infection Inflammation/Immunology
Vilobelimab (CaCP-29, IFX-1) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc .

HY-P99913

Eflapegrastim	c-Fms	Inflammation/Immunology Cancer
Eflapegrastim is a human IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7032

Uridine 5′-diphosphoglucose disodium salt 5 Publications Verification UDP-D-Glucose disodium salt	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite P2Y Receptor
Uridine 5’-diphosphoglucose (UDP-glucose) disodium salt, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium salt is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium salt is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .

HY-N7885

(25R)-Spirost-4-ene-3,12-dione (-)-(25R)-Spirost-4-ene-3,12-dione	Natural Products Polygonum chinense Linn. Polygonaceae Source classification Plants	Others
(25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells .

HY-125527

Resolvin D1 RvD1	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .

HY-W744699

Larixol (+)-Larixol	Larix decidua Miller Structural Classification Natural Products Pinaceae Source classification Plants	Src ERK Akt
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

HY-145542

Isovalerylcarnitine chloride	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Proteasome Endogenous Metabolite
Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca ²⁺-dependent proteinase (calpain) of human neutrophils .

HY-101408

Docosatrienoic Acid cis-13,16,19-docosatrienoic acid; (13Z,16Z,19Z)-13,16,19-Docosatrienoic acid	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Docosatrienoic acid is a rare ω-3 fatty acid; inhibits LTB4 binding to pig neutrophil membranes with an K_i of 5 μM.

HY-N3566

Cepharadione A	Structural Classification Natural Products Liliaceae Piper betle L. Source classification Piperaceae Allium cepa L. Plants	Others
Cepharadione A can be isolated from the roots of Piper betle Linn. Cepharadione A inhibits FMLP/CB induced elastase release by human neutrophils .

HY-120333

Antibiotic PF 1052	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields Other Antibiotics	Antibiotic Fungal Bacterial
Antibiotic PF 1052 is an antibiotic extracted from a natural product library. Antibiotic PF 1052 has an inhibitory effect on murine neutrophil migration .

HY-P0261

Indolicidin	Infection Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Bacterial
Indolicidin is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils.

HY-N8217

4-O-Cinnamoylquinic acid	Structural Classification Viscum Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields Loranthaceae	Others
4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .

HY-N6946

Mitraphylline	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Inflammation/Immunology Disease Research Fields	NF-κB
Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .

HY-N11934

Piperkadsin A	Structural Classification Monophenols Source classification Phenols Piperaceae Plants Piper kadsura (Choisy) Ohwi	Reactive Oxygen Species
Piperkadsin A is a potent inhibitor of ROS. Piperkadsin inhibits PMA-induced ROS production in human polymorphonuclear neutrophils with an IC₅₀ of 4.3 μM .

HY-N7314

Asebogenin	Structural Classification Populus balsamifera L. Source classification Phenols Polyphenols Plants Salicaceae	Syk
Asebogenin has antimalarial activity in vitro . Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps .

HY-N1942

5-O-Demethylnobiletin 1 Publications Verification 5-Demethylnobiletin	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavones Rutaceae Plants Citrus Disease Research Fields Cancer	Lipoxygenase Leukotriene Receptor
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB₄) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-N8152

Randialic acid B	Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants Disease Research Fields Inflammation/Immunology	Reactive Oxygen Species
Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo .

HY-N5051

25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside	Liliaceae Classification of Application Fields Source classification Liriope spicata (Thunb.) Lour. Plants Disease Research Fields Inflammation/Immunology Steroids	Others
25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside shows inhibitory activity of neutrophil respiratory burst stimulated by PMA(phorbol myristate acetate) .

HY-124210

Formycin B	Structural Classification Microorganisms Antibiotics Source classification	Antibiotic Parasite
Formycin B is an antibiotic, which exhibits antiparasitic activity against Leishmania. Formycin B exhibits toxicity to leukocytes, reversibly decreases neutrophils. Formycin B can be used in research about myeloid leukemia .

HY-N6946R

Mitraphylline (Standard)	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants	NF-κB
Mitraphylline (Standard) is the analytical standard of Mitraphylline. This product is intended for research and analytical applications. Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .

HY-N1942R

5-O-Demethylnobiletin (Standard)	Structural Classification Flavonoids Flavones Rutaceae Plants Citrus	Lipoxygenase Leukotriene Receptor
5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-N1733

2′-Hydroxydaidzein	Structural Classification Flavonoids Leguminosae Source classification Plants Crotalaria pallida Ait. Isoflavones	Others
2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively .

HY-113434B

5-HETE (±)-5-HETE	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
5-HETE ((±)-5-HETE), a fatty acid, is a oxidative derivative of Arachidonic acid. 5-HETE is a mixture of 5(S)-HETE and 5(R)-HETE. 5-HETE is a potent aggregating agent that induces the aggregation of neutrophils with an IC₅₀ value of 200 nM .

HY-P1508

Bactenecin Bactenecin, bovine	Infection Structural Classification Animals Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Fungal Antibiotic
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-P1508A

Bactenecin TFA Bactenecin, bovine TFA	Infection Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Bacterial Fungal
Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	Structural Classification Source classification Phenols Polyphenols Hypoxis angustifolia Lam. Plants Asparagaceae Juss.	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-156241

Meliadubin B	Melia dubia Cav. Triterpenes Structural Classification Terpenoids Source classification Plants Meliaceae	NO Synthase Fungal
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC₅₀ of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC₅₀ of 182.50 μM.

HY-W020790

Sialyl-Lewis X sLeX	Structural Classification Polysaccharides Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Endogenous Metabolite
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

HY-N13177

25(S)Ruscogenin 3-O-α-L-rhamnopyranoside	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Source classification Plants Steroids	Others
25(S)Ruscogenin 3-O-α-L-rhamnopyranoside is from the fibrous roots of Ophiopogon japonicus and Liriope spicata var. prolifera. 25(S)Ruscogenin 3-O-α-L-rhamnopyranoside exhibits anti-inflammatory activity by inhibiting neutrophil responses to PMA (HY-18739), with an IC₅₀ value of 1.13 μM .

HY-W027951

N,N'-Dimethylthiourea DMTU	Structural Classification Natural Products Liliaceae Classification of Application Fields Source classification Allium sativum Linn. Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action .

HY-N1735

2′-Hydroxygenistein	Structural Classification Flavonoids Leguminosae Source classification Crotalaria pallida Ait. Plants Isoflavones	Others
2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils, with IC₅₀ values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively .

HY-N12126

Sydowinin B MS-347b	Structural Classification Microorganisms Xanthones Source classification Phenols	Others
Sydowinin B (MS-347b) is a active compound and can be isolated from A. sydowii. Sydowinin B shows has immunosuppressant activity .

HY-B2176R

ATP (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms other families Animals Other Alkaloids Source classification Plants Endogenous metabolite	Endogenous Metabolite
ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation . In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs . ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner . ATP promotes neutrophil chemotaxis in vitro . In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo . ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo .

HY-N2071

Cedrol 1 Publications Verification (+)-Cedrol; α-Cedrol	Structural Classification Cedrus deodara (Roxburgh) G. Don Classification of Application Fields Pinaceae Terpenoids Sesquiterpenes Source classification Plants Inflammation/Immunology Disease Research Fields Cancer	Cytochrome P450 Fungal Apoptosis Caspase Platelet-activating Factor Receptor (PAFR)
Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties .

HY-N4323

14-Deoxyandrographolide	Structural Classification Andrographis paniculata (Burm. F.) Nees Acanthaceae Terpenoids Source classification Diterpenoids Plants	Calcium Channel Apoptosis Caspase
14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A .

HY-N4323R

14-Deoxyandrographolide (Standard)	Structural Classification Andrographis paniculata (Burm. F.) Nees Acanthaceae Terpenoids Source classification Diterpenoids Plants	Calcium Channel Apoptosis Caspase
14-Deoxyandrographolide (Standard) is the analytical standard of 14-Deoxyandrographolide. 14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A .

HY-N2071R

Cedrol (Standard)	Structural Classification Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Source classification Plants	Cytochrome P450 Fungal Apoptosis Caspase
Cedrol (Standard) is the analytical standard of Cedrol. This product is intended for research and analytical applications. Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties.

Species:	Human (17) Mouse (5) Rat (2) Cynomolgus (1) Pig (1)
Tag:	His (19) Tag Free (4) GST (3) Fc (1)
Source:	HEK293 (13) CHO (3) Sf9 insect cells (3) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P76870

	DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc) neutrophil defensin 3; HNP-3; neutrophil defensin 2; HNP-2; DEF3	Human	HEK293
	The DEFA3/defensin alpha 3 protein is a potent effector in innate immunity against a variety of infectious agents, including bacteria, fungi, and viruses. It neutralizes bacterial toxins, such as Bacillus anthracis lethal factor and Staphylococcus aureus leukocidin, and plays a key role in blocking herpes simplex virus infection by preventing viral attachment. DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc) is the recombinant human-derived DEFA3/Defensin alpha 3 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc) is 56 a.a., with molecular weight of ~36 KDa.

HY-P73298

	MMP-8 Protein, Human (HEK293) neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Human	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with N-Met labeled tag. The total length of MMP-8 Protein, Human (HEK293) is 447 a.a., with molecular weight of ~65 kDa.

HY-P73808

	MMP-8 Protein, Mouse (HEK293) neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Mouse	HEK293
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III.It is implicated in the breakdown of collagen fibers during uterine involution.MMP-8 Protein, Mouse (HEK293) is the recombinant mouse-derived MMP-8 protein, expressed by HEK293 , with tag free.

HY-P72179

	ELANE Protein, Human (GST) Bone marrow serine protease; ELA2; ELANE; Elastase 2; Elastase 2 neutrophil; Elastase neutrophil expressed; Elastase-2; ELNE_HUMAN; GE; Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Medullasin; NE; neutrophil elastase; PMN E; PMN elastase; Polymorphonuclear elastase; SCN1	Human	E. coli
	ELANE is a serine protease that critically regulates natural killer cells, monocytes, and granulocytes by inhibiting C5a-dependent neutrophil enzyme release and chemotaxis, thereby shaping immune responses. It also inhibits pyroptosis by cleaving GSDMB, affecting the regulation of programmed cell death. ELANE Protein, Human (GST) is the recombinant human-derived ELANE protein, expressed by E. coli , with N-GST labeled tag. The total length of ELANE Protein, Human (GST) is 238 a.a., with molecular weight of ~52.6 kDa.

HY-P70569

	IL-8/CXCL8 Protein, Human (HEK293, His) 1 Publications Verification Interleukin-8; IL-8; C-X-C Motif Chemokine 8; CXCL8; Emoctakin; Granulocyte Chemotactic Protein 1; GCP-1; Monocyte-Derived neutrophil Chemotactic Factor; MDNCF; Monocyte-Derived neutrophil-Activating Peptide; MONAP; neutrophil-Activating Protein 1; NAP-1	Human	HEK293
	Interleukin-8 (IL-8), also known as CXCL8 or NAP-1, is a pro-inflammatory CXC chemokine. IL-8 acts on human neutrophils via two receptors, CXCR1 and CXCR2. IL-8 has a conserved Glu-Leu-Arg (ELR) N-terminal motif, and is an agonist for CXCR1/CXCR2. IL-8 is produced by various cells including leukocytes, endothelial cells, and epithelial cells. IL-8/CXCL8 Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 79 amino acids (E21-S99).

HY-P700133AF

	Animal-Free IL-8/CXCL8 Protein, Human (His) Interleukin-8; IL-8; C-X-C Motif Chemokine 8; Emoctakin; Granulocyte Chemotactic Protein 1; GCP-1; Monocyte-Derived neutrophil Chemotactic Factor; MDNCF; Monocyte-Derived neutrophil-Activating Peptide; MONAP; neutrophil-Activating Protein 1; NAP-1; Protein 3-10C; T-Cell Chemotactic Factor; IL8; CXCL8	Human	E. coli
	IL-8/CXCL8 protein, a vital chemotactic factor, orchestrates inflammatory responses by attracting neutrophils, basophils, and T-cells to clear pathogens. It activates neutrophils and binds to CXCR1/CXCR2 receptors, initiating downstream signaling pathways. IL-8/CXCL8 homodimerizes, disrupted by tick evasin-3, and interacts with TNFAIP6, potentially regulating chemokine activity in the inflammatory microenvironment. Animal-Free IL-8/CXCL8 Protein, Human (His) is the recombinant human-derived animal-FreeIL-8/CXCL8 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-8/CXCL8 Protein, Human (His) is 72 a.a., with molecular weight of ~9.32 kDa.

HY-P70290

	Neutrophil cytosol factor 1 Protein, Human (His) rHuneutrophil cytosol factor 1/NCF1, His; NCF-1; 47 kDa autosomal chronic granulomatous disease protein/47 kDa neutrophil oxidase factor; NCF-47K; neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2/SH3 and PX domain-containing protein 1A; p47-phox	Human	E. coli
	Neutrophil cytoplasmic factor 1 (NCF1) is essential for activation of the NADPH oxidase complex, which is essential for superoxide production. It cooperates with NCF2 to form a core association in the complex, interacting with NCF4, CYBB and CYBA. Neutrophil cytosol factor 1 Protein, Human (His) is the recombinant human-derived Neutrophil cytosol factor 1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Neutrophil cytosol factor 1 Protein, Human (His) is 390 a.a., with molecular weight of 45-50 kDa.

HY-P73809

	MMP-8 Protein, Mouse (CHO, His) neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Mouse	CHO
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III.It is implicated in the breakdown of collagen fibers during uterine involution.MMP-8 Protein, Mouse (CHO, His) is the recombinant mouse-derived MMP-8 protein, expressed by CHO , with C-His labeled tag.

HY-P700250AF

	Animal-Free IL-8/CXCL8 Protein, Pig (His) Interleukin-8; IL-8; C-X-C Motif Chemokine 8; CXCL8; Emoctakin; Granulocyte Chemotactic Protein 1; GCP-1; Monocyte-Derived neutrophil Chemotactic Factor; MDNCF; Monocyte-Derived neutrophil-Activating Peptide; MONAP; neutrophil-Activating Protein 1; NAP-1	Pig	E. coli
	IL-8/CXCL8 protein, a vital chemotactic factor, orchestrates inflammatory responses by attracting neutrophils, basophils, and T-cells to clear pathogens. It activates neutrophils and binds to CXCR1/CXCR2 receptors, initiating downstream signaling pathways. IL-8/CXCL8 homodimerizes, disrupted by tick evasin-3, and interacts with TNFAIP6, potentially regulating chemokine activity in the inflammatory microenvironment. Animal-Free IL-8/CXCL8 Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-8/CXCL8 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-8/CXCL8 Protein, Pig (His) is 78 a.a., with molecular weight of ~10.04 kDa.

HY-P74656

	p67phox Protein, Human (sf9) neutrophil cytosol factor 2; NCF-2; NOXA2; P67PHOX	Human	Sf9 insect cells
	p67phox is central to activating NADPH oxidase, crucial for superoxide production. Forming a heterodimer with CYBA and CYBB, and interacting with NCF4 and NCF1, p67phox establishes vital connections within the complex. Its versatile associations include SYTL1, RAC1, NOXO1, S100A8, calprotectin (S100A8/9), and GBP7, highlighting its regulatory role. Enhanced interaction with CYBB in the presence of GBP7 underscores the dynamic nature of these protein-protein associations in orchestrating superoxide generation. p67phox Protein, Human (sf9) is the recombinant human-derived p67phox protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of p67phox Protein, Human (sf9) is 526 a.a., with molecular weight of ~60 kDa.

HY-P79114

	Lipocalin-2/NGAL Protein, Cynomolgus (CHO, His) NGAL; LCN2; Lipocalin-2; 24p3; MSFI; neutrophil Gelatinase-associated Lipocalin	Cynomolgus	CHO
	Lipocalin-2/NGAL is a multifaceted iron transporter involved in multiple biological processes, including apoptosis, innate immunity, and kidney development. Lipocalin-2 dynamically affects cellular iron concentration through binding to the siderophore 2,3-dihydroxybenzoate. Lipocalin-2/NGAL Protein, Cynomolgus (CHO, His) is the recombinant cynomolgus-derived Lipocalin-2/NGAL protein, expressed by CHO , with C-His labeled tag.

HY-P74774

	Lipocalin-2/NGAL Protein, Rat (sf9, His) neutrophil gelatinase-associated lipocalin; NGAL; Lipocalin 24p3; p25; LCN2	Rat	Sf9 insect cells
	Lipocalin-2/NGAL is a multifaceted iron transporter involved in multiple biological processes, including apoptosis, innate immunity, and kidney development. Lipocalin-2 dynamically affects cellular iron concentration through binding to the siderophore 2,3-dihydroxybenzoate. Lipocalin-2/NGAL Protein, Rat (sf9, His) is the recombinant rat-derived Lipocalin-2/NGAL protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P72507

	MMP-8 Protein, Human (HEK293, His) 1 Publications Verification neutrophil collagenase; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; MMP8; CLG1	Human	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293, His) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-8 Protein, Human (HEK293, His) is 447 a.a., with molecular weight of approximately 64.09 kDa.

HY-P74655

	p67phox Protein, Human (sf9, His-GST) neutrophil cytosol factor 2; NCF-2; NOXA2; P67PHOX	Human	Sf9 insect cells
	p67phox is central to the activation of NADPH oxidase, which is critical for superoxide production. p67phox forms heterodimers with CYBA and CYBB and interacts with NCF4 and NCF1 to establish important connections within the complex. p67phox Protein, Human (sf9, His-GST) is the recombinant human-derived p67phox protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of p67phox Protein, Human (sf9, His-GST) is 526 a.a., with molecular weight of 80-90 kDa.

HY-P71303

	Serpin B1 Protein, Human (HEK293, His) Leukocyte elastase inhibitor; SERPINB1; Monocyte/neutrophil elastase inhibitor; M/NEI; Peptidase inhibitor 2; PI-2	Human	HEK293
	Serpin B1 protein is an important neutrophil serine protease inhibitor that regulates innate immune responses by protecting cells from cytoplasmic proteases during stress. It inhibits various neutrophil proteases, including elastase and chymotrypsin, and blocks GZMH activity intracellularly. Serpin B1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B1 Protein, Human (HEK293, His) is 379 a.a., with molecular weight of ~44.0 kDa.

HY-P70658

	Lipocalin-2/NGAL Protein, Mouse (HEK293, His) neutrophil gelatinase-associated lipocalin; NGAL; Lipocalin-2; SV-40-induced 24P3 protein; Siderocalin LCN2; p25; LCN2	Mouse	HEK293
	Lipocalin-2/NGAL Protein, Mouse (HEK293, His) is an 20-28 kDa NGAL protein with a His-flag, which is expressed in HEK293 cells. NGAL is an antibacterial factor of natural immunity, and an acute-phase protein.

HY-P70658A

	Lipocalin-2/NGAL Protein, Mouse (HEK293, C-His) neutrophil gelatinase-associated lipocalin; NGAL; Lipocalin-2; SV-40-induced 24P3 protein; Siderocalin LCN2; p25; LCN2	Mouse	HEK293
	Lipocalin-2/NGAL Protein, Mouse (HEK293, His) is an 20-28 kDa NGAL protein with a His-flag, which is expressed in HEK293 cells. NGAL is an antibacterial factor of natural immunity, and an acute-phase protein.

HY-P7152

	CXCL3/CINC-2 alpha Protein, Rat (CHO) rRtCXCL3; C-X-C motif chemokine 3; Cytokine-induced neutrophil chemoattractant 2; CINC-2; MIP2-alpha/beta	Rat	CHO
	CXCL3 is a chemoattractant for neutrophils and belongs to CXC chemokine subfamily. CXCL3 is a secreted growth factor that signals through its cognate receptor CXCR2. CXCL3 is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis. CXCL3 Protein, Rat (CHO) is produced in CHO cells.

HY-P70509

	PRTN3 Protein, Human (HEK293, His) Myeloblastin; AGP7; C-ANCA Antigen; Leukocyte Proteinase 3; PR-3; PR3; neutrophil Proteinase 4; NP-4; P29; Wegener Autoantigen; PRTN3; MBN	Human	HEK293
	PRTN3 is a serine protease that broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation. It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2 and enhances vascular integrity during neutrophil transendothelial migration. PRTN3 Protein, Human (HEK293, His) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PRTN3 Protein, Human (HEK293, His) is 224 a.a., with molecular weight of ~34.0 kDa.

HY-P72171

	DEFA1 Protein, Human (GST) alpha 1; DEF1; DEF1_HUMAN; DEFA1; DEFA1B; DEFA2; Defensin 1; Defensin; Defensin; alpha 1; Defensin; alpha 1; myeloid related sequence; Defensin; alpha 2; HNP-1; HNP-2; HNP1; HP-1; HP-2; HP1; HP2; MRS; Myeloid related sequence; neutrophil defensin 1; neutrophil defensin 2	Human	E. coli
	The DEFA1 protein is a multifunctional effector in innate immunity that exhibits antibiotic-like properties against bacteria, fungi, and viruses. It promotes immune defense by activating antigen-presenting cells (APCs) and inhibiting bacterial cell wall synthesis by interacting with lipid II. DEFA1 Protein, Human (GST) is the recombinant human-derived DEFA1 protein, expressed by E. coli , with N-GST labeled tag.

HY-P71156

	Lipocalin-2/NGAL Protein, Human (HEK293, His) neutrophil gelatinase-associated lipocalin; NGAL; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; HNL; NGAL	Human	HEK293
	Lipocalin-2/NGAL is an iron transporter that plays a crucial role in various cellular processes. It interacts with the siderophore 2,3-DHBA to transport iron into or out of cells depending on cellular needs. Lipocalin-2/NGAL Protein, Human (HEK293, His) is the recombinant human-derived Lipocalin-2/NGAL protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70509A

	PRTN3 Protein, Human (HEK293, C-His) Myeloblastin; AGP7; C-ANCA Antigen; Leukocyte Proteinase 3; PR-3; PR3; neutrophil Proteinase 4; NP-4; P29; Wegener Autoantigen; PRTN3; MBN	Human	HEK293
	PRTN3 is a serine protease that broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation.It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2 and enhances vascular integrity during neutrophil transendothelial migration.PRTN3 Protein, Human (HEK293, C-His) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7801

	CD177 Protein, Human (HEK293, His) rHuCD177, His; CD177 Antigen; Human neutrophil Alloantigen 2a; HNA-2a; NB1 Glycoprotein; NB1 GP; Polycythemia Rubra Vera Protein 1; CD177; NB1; PRV1	Human	HEK293
	CD177 Protein, Human (HEK293, His) is a recombinant human CD177 expressed in HEK 293 cells with a His tag at the N-terminus. CD177 Protein is an important biomarker of myeloproliferative diseases.

HY-P700558

	GRO-alpha/CXCL1 Protein, Human (His) Growth-Regulated Alpha Protein; C-X-C Motif Chemokine 1; GRO-Alpha(1-73); Melanoma Growth Stimulatory Activity; MGSA; neutrophil-Activating Protein 3; NAP-3; CXCL1; GRO; GRO1; GROA; MGSA; SCYB1	Human	E. coli
	GRO-alpha/CXCL1 protein attracts neutrophils and potentially contributes to inflammation through autocrine effects on endothelial cells. Processed forms of GRO-alpha, including GRO-alpha(4-73), GRO-alpha(5-73), and GRO-alpha(6-73), exhibit 30-fold greater chemotactic activity than the full-length protein. GRO-alpha/CXCL1 Protein, Human (His) is the recombinant human-derived GRO-alpha/CXCL1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700559

	GRO-alpha/CXCL1 Protein, Mouse (His) Growth-Regulated Alpha Protein; C-X-C Motif Chemokine 1; GRO-Alpha(1-73); Melanoma Growth Stimulatory Activity; MGSA; neutrophil-Activating Protein 3; NAP-3; CXCL1; GRO; GRO1; GROA; MGSA; SCYB1	Mouse	E. coli
	GRO-alpha (CXCL1) Protein, with chemotactic properties, attracts and activates neutrophils during inflammatory responses. This hematoregulatory chemokine also suppresses hematopoietic progenitor cell proliferation, emphasizing its intricate role in hematopoiesis regulation. The truncated form KC(5-72) notably exhibits significantly enhanced hematopoietic activity in vitro. GRO-alpha/CXCL1 Protein, Mouse (His) is the recombinant mouse-derived GRO-alpha/CXCL1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GRO-alpha/CXCL1 Protein, Mouse (His) is 68 a.a., with molecular weight of 11.5 kDa.

HY-P70508

	GRO-alpha/CXCL1 Protein, Human (HEK293, His) 1 Publications Verification Growth-Regulated Alpha Protein; C-X-C Motif Chemokine 1; GRO-Alpha(1-73); Melanoma Growth Stimulatory Activity; MGSA; neutrophil-Activating Protein 3; NAP-3; CXCL1; GRO; GRO1; GROA; MGSA; SCYB1	Human	HEK293
	CXCL1 (Chemokine (C-X-C motif) ligand 1), also known as GRO alpha, NAP-3 or MGSA, belongs to the sub-family of CXC chemokine. CXCL1 is involved in the development of many inflammatory diseases, including the induction of angiogenesis and recruitment of neutrophils. CXCL1 is produced by many cell types, and activates CXCR2 and, at high levels, CXCR1. GRO-alpha/CXCL1 Protein, Human (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 73 amino acids (A35-N107).

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Cat. No.	Product Name	Chemical Structure

HY-14648S5

Dexamethasone-d3-1

Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S

Dexamethasone-d5

Dexamethasone-d₅ is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].

HY-125527S

Resolvin D1-d5

Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

HY-14648S3

Dexamethasone-4,6α,21,21-d4

Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S1

Dexamethasone-d5-1

Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S2

Dexamethasone-d4

Dexamethasone-d₄ is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81215

	Neutrophil Elastase Antibody Bone Marrow Serine Protease; ELA 2; ELA2; ELANE; Elastase 2; Elastase-2; Elastase 2 neutrophil; Elastase neutrophil expressed; Elastase-2; ELNE_HUMAN; GE antibody Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Leukocyte Elastase Precursor; Medullasin; NE; neutrophil elastase; neutrophill elastase; PMN E; PMN Elastase; Polymorphonuclear elastase; SCN1; Serine protease; SERP1.	WB, IHC-P, ICC/IF, FC	Human
	Neutrophil Elastase Antibody is an unconjugated, approximately 26 kDa, rabbit-derived, anti-Neutrophil Elastase monoclonal antibody. Neutrophil Elastase Antibody can be used for: WB,IHC-P,ICC/IF,FC expriments in human background without labeling.

HY-P83285

	MMP8 Antibody (YA3030) HNC; CLG1; MMP-8; PMNL-CL; COLLAGENASE I; neutrophil; matrix metalloproteinase 8	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	MMP8 Antibody (YA3030) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3030), targeting MMP8, with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). MMP8 Antibody (YA3030) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P81195

	NOX2 Antibody AMCBX2; CGD; CGD91-phox; CY24B_HUMAN; CYBB; Cytochrome b 245, beta polypeptide; Cytochrome b(558) beta chain; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome; P91 PHOX; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	NOX2 Antibody is an unconjugated, approximately 65 kDa, rabbit-derived, anti-NOX2 polyclonal antibody. NOX2 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow, horse, rabbit background without labeling.

HY-P81179

	CXCL5 Antibody AMCFII; C-X-C motif chemokine 5; Cxcl5; CXCL5_HUMAN; ENA-78(1-78); ENA-78(9-78); ENA78; Epithelial derived neutrophil activating peptide 78; Epithelial derived neutrophil activating protein 78; Epithelial-derived neutrophil-activating protein 78; GCP2; LIX; neutrophil activating peptide ENA 78; neutrophil-activating peptide ENA-78; SCYB5; Scyb6; Small inducible cytokine B5; Small inducible cytokine subfamily B member 5; Small-inducible cytokine B5.	WB, ICC/IF, IP	Human
	CXCL5 Antibody is an unconjugated, approximately 10 kDa, rabbit-derived, anti-CXCL5 monoclonal antibody. CXCL5 Antibody can be used for: WB,ICC/IF,IP expriments in human background without labeling.

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neutrophil

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