Search Result
Results for "
Isomers
" in MedChemExpress (MCE) Product Catalog:
10
Biochemical Assay Reagents
63
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-14620A
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Others
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Others
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Farnesene (mixture of isomers) is a farnesene with mixture of isomers. Farnesene is a herbivore-induced plant volatile (HIPV). Farnesene has an important effect on insect resistance in many plant species .
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- HY-D1249
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Fluorescent Dye
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Others
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Calcein mixture of isomers is a calcium-dependent fluorescent molecule. Calcein mixture of isomers can be used to study bone metabolism (in vivo) and to stain depressed areas (in vitro). Calcein mixture of isomers can also be used for fluorometry and EDTA titration of calcium.
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- HY-W018772S15
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Endogenous Metabolite
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Inflammation/Immunology
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D-Ribose(mixture of isomers)- 13C5 isomers)- 13C5 is the 13C labeled D-Ribose(mixture of isomers)[1]. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner[1].
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- HY-W018772
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Endogenous Metabolite
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Inflammation/Immunology
Cancer
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D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .
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- HY-126304A
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Others
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Others
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Glycerophosphoric acid (disodium salt hydrate) (α and β mixture) is a complex contains α and β Glycerophosphoric acid isomers.
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-
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- HY-W763562
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- HY-159669
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HIV Protease
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Infection
Inflammation/Immunology
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Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .
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- HY-W018772R
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Endogenous Metabolite
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Inflammation/Immunology
Cancer
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D-Ribose(mixture of isomers) (Standard) is the analytical standard of D-Ribose(mixture of isomers). This product is intended for research and analytical applications. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .
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- HY-132637S
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Isotope-Labeled Compounds
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Others
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Chlorfenvinphos-d10(Mixture of cis-trans isomers) is the deuterium labeled Chlorfenvinphos (Mixture of cis-trans isomers)[1].
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- HY-W250128
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DDSA (mixture of Isomers)
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Biochemical Assay Reagents
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Others
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2-Dodecen-1-Ylsuccinic Anhydride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Dodecenylsuccinic anhydride (mixture of isomers) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-149053A
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Others
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Others
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(S)-OY-101 is an isomer of OY-101 (HY-149053).
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- HY-139586A
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MK-1454 (isomer 1)
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STING
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Cancer
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Ulevostinag isomer 1 (MK-1454 isomer 1) is the isomer of Ulevostinag. Ulevostinag is a STING agonist .
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- HY-139586D
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MK-1454 (isomer 4)
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STING
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Cancer
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Ulevostinag isomer 4 (MK-1454 isomer 4) is the isomer of Ulevostinag. Ulevostinag is a STING agonist .
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- HY-139586B
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MK-1454 (isomer 2)
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STING
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Cancer
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Ulevostinag isomer 2 (MK-1454 isomer 2) is the isomer of Ulevostinag. Ulevostinag is a STING agonist .
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- HY-100913
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- HY-W776824
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Biochemical Assay Reagents
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Others
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2-Phthalimidolactosamine,heptaacetate (mixture of isomers) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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- HY-123382
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Others
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Inflammation/Immunology
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GSK-1482160 isomer is the isomer of GSK-1482160. GSK1482160 is a potent P2X7 antagonist with excellent biological activity .
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- HY-107213
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- HY-135406
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- HY-A0152A
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-
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- HY-107501
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(Rac)-1-Oleoyl-sn-glycero-3-phosphate sodium; (Rac)-1-Oleoyl-LPA sodium
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Others
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Neurological Disease
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(Rac)-1-Oleoyl lysophosphatidic acid ((Rac)-1-Oleoyl-sn-glycero-3-phosphate) sodium is the racemic isomer of 1-Oleoyl lysophosphatidic acid sodium (HY-107614) .
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- HY-116494A
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Others
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Cancer
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(6R)-ML753286 is an isomer of ML753286 (HY-116494). ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species .
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- HY-10193A
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JAK
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Cancer
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(1R)-AZD-1480 is the (1R) chiral isomer of AZD-1480, an ATP competitive JAK1 and JAK2 inhibitor .
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- HY-N4283A
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Fungal
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Infection
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(E)-Coniferyl alcohol is the isomer of Coniferyl alcohol. Coniferyl alcohol is an intermediate in biosynthesis of eugenol and of stilbenoids and coumarin. Coniferyl alcohol specifically inhibits fungal growth .
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- HY-101284A
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Others
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Cancer
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(E/Z)-DMU2105 is the E/Z isomer of DMU2105 (HY-101284). DMU2105 is a CYP1B1 inhibitor .
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- HY-33338
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N-Acetylsalicylamide
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Others
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Others
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Salacetamide (N-Acetylsalicylamide) is the stable isomer of O-Acetylsalicylamide, is a product for proteomics research .
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- HY-119712A
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7-Biopterin
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Endogenous Metabolite
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Metabolic Disease
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L-Primapterin (7-Biopterin) is the 7-isomer of L-biopterin. L-Primapterin is a characteristic marker of hyperphenylalaninemia variant primapterinuria, which is excreted in the urine .
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- HY-107608A
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5(S),12(S)-LTB4; 5(S),12(S)-DiHETE
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Others
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Others
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5(S),12(S)-Leukotriene B4 (5(S),12(S)-LTB4; 5(S),12(S)-DiHETE) is a stereochemical isomer of LTB4 (HY-107608) .
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- HY-105279
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PP 56
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Others
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Others
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α-Trinositol (PP 56) is an isomer of the intracellular messenger IP3. α-Trinositol can be used in the study of in vitro cytotoxicity and glutamate-induced glial cytotoxic swelling and injury .
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- HY-113102B
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Endogenous Metabolite
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Cancer
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9(Z),11(Z)-octadecadienoic acid is an isomer of linoleic acid and has antitumor activity (EC 50 = 446.1 µM) .
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- HY-136672
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Fluorescent Dye
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Others
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(E)-HBT-O is an isomer of HBT-O. HBT-O is a fluorescent probe used to monitor subtle pH fluctuations in living cells .
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- HY-W587978
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Lagocholic acid; 3α,7α,12β-Trihydroxy-5β-cholanic acid
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Endogenous Metabolite
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Metabolic Disease
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12β-Hydroxyisocholic acid (Lagocholic acid) is a bile acid isomer that can be used in the study of bile acid metabolism .
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- HY-75992
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VD/VDR
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Others
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trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease .
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- HY-107842
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NSC693627
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Others
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Cancer
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(Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis .
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- HY-W015084A
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β-Lonone
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Apoptosis
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Cancer
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(E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .
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- HY-121582
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(E)-EPH 116
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Others
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Cancer
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(E)-SI-2 is an isomer of SI-2, an inhibitor of the steroid receptor coactivator SRC-3. SI-2 has anticancer activity and increases the number of cytotoxic immune cells in mice with breast cancer .
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- HY-18295A
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rel-LY500307
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Estrogen Receptor/ERR
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Neurological Disease
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rel-Erteberel is rel isomer of Erteberel (HY-18295). Erteberel is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively. Erteberel has anti-tumor activities .
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- HY-N8549A
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Endogenous Metabolite
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Metabolic Disease
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5-Dihydrocortisone is a 5-Dihydrocortisone with mixture of isomers. 5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver
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- HY-N4147
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Others
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Metabolic Disease
Inflammation/Immunology
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Eleutheroside D is an active lignan isolated from the root of Eleutherococcus senticosus, has anti-inflammatory and hypoglycemic activities . Eleutheroside D is an optical isomer of Eleutheroside E (HY-N0272) .
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- HY-114850
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5-trans-PGF2β
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Others
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Endocrinology
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5-trans Prostaglandin F2β (5-trans-PGF2β) is the 9β-hydroxy isomer of 5-trans PGF2α .
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- HY-120723
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Others
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Others
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(Rac)-Phox-I1 is a racemic isomer of Phox-I1. Phox-I1 is a p67 phox inhibitor. Phox-I1 inhibits ROS production .
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- HY-N0117A
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(Z)-Couroupitine B; (Z)-Indigo red; (Z)-Indigopurpurin
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Apoptosis
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Cancer
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(Z)-Indirubin is an isomer of Indirubin (HY-N0117). Indirubin is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .
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- HY-113756
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Others
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Others
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trans-Latanoprost acid is an isomer of Latanoprost acid. trans-Latanoprost acid may have the activity of reducing intraocular pressure. trans-Latanoprost acid is mainly prepared as an analytical standard for impurity detection and quantification .
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- HY-137628
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PKA
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Cancer
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Sp-8-PIP cAMP sodium is a non-corresponding isomer of 8-Piperidino-cAMP. 8-Piperidino-cAMP binds with high affinity to site A of the regulatory subunit of cAMP-dependent protein kinase type I (AI). Sp-8-PIP cAMP sodium can be used as an antagonist of cAMP-induced activation .
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- HY-B0172B
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Endogenous Metabolite
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Endocrinology
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Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate .
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- HY-W015084AR
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Apoptosis
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Cancer
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(E)-β-Ionone (Standard) is the analytical standard of (E)-β-Ionone. This product is intended for research and analytical applications. (E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .
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- HY-B0055
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Cyclopentacycloheptene
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HIV
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Infection
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Azulene (Cyclopentacycloheptene) is as an isomer of naphthalene with high anti-HIV activity. Azulene, isolated from the distillation of chamomile oil, is a scaffold in medicinal chemistry .
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- HY-14405B
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(R)-GW679769
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Neurokinin Receptor
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Cancer
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(R)-Casopitant ((R)-GW679769) is the isomer of Casopitant (HY-14405). Casopitant is a NK(1)-receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting .
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- HY-N7438
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Others
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Others
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Mogroside VI A, an isomer of Mogroside VI isolated from Luo Han Guo, exerts sweetness property. Mogroside VI A can be used for sweetener and/or taste modifier research .
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- HY-N12762
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Liposome
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Others
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DGTS, as described, is a structural isomer of DGTA and one of the most common betaine lipids found in microalgae, particularly abundant in Chlorophyceae . DGTS is a helper lipid that is structurally similar to DSPE or DOPE.
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- HY-W926789
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- HY-114867
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15(R)-17-phenyl trinor PGF2α ethyl amide
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Others
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Endocrinology
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(15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide) is a prostaglandin analog used to treat glaucoma and ocular hypertension. (15R)-Bimatoprost is an isomer of Bimatoprost with an inverted (β) hydroxyl group on C-15 .
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- HY-125858B
-
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Drug-Linker Conjugates for ADC
MDM-2/p53
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Others
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(S,R,S)-MI-1061 is the isomer of MI-1061(HY-125858). (S,R,S)-MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs). MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity .
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- HY-16657A
-
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MMP
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Inflammation/Immunology
Cancer
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(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor .
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- HY-15648H
-
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Others
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Cancer
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GSK-J5 hydrochloride is a cell-permeable ester derivative of GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an isomer of GSK-J4 (HY-15648B) and often used as a negative group .
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- HY-145056
-
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Others
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Cancer
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ART615 is the related isomer of ART558. ART615, the inactive of ART558, elicits <10% Polθ inhibition at 12 µM, thus serving as a control for ART558 (IC50=7.9 nM) .
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- HY-100714B
-
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L-APV; L-2-Amino-5-phosphonovaleric acid
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iGluR
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Neurological Disease
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L-AP5 (L-APV; L-2-Amino-5-phosphonovaleric acid) is an NMDA antagonist and is the isomer of D-AP5 (HY-100714A).
L-AP5 shows a relatively weak amino acid and synaptic blocking activity .
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- HY-101884A
-
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Others
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Neurological Disease
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Biotinylated-D-lysine TFA is a conjugate of L-biotin and D-lysine, where the carboxylate of L-biotin is coupled with the ϵ-amine of D-lysine via a secondary amide bond. Biotinylated-D-lysine TFA is an isomer of the neuroanatomical tracer Biocyte.
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- HY-B0055R
-
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HIV
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Infection
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Azulene (Standard) is the analytical standard of Azulene. This product is intended for research and analytical applications. Azulene (Cyclopentacycloheptene) is as an isomer of naphthalene with high anti-HIV activity. Azulene, isolated from the distillation of chamomile oil, is a scaffold in medicinal chemistry .
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- HY-15648I
-
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Others
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Cancer
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GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A .
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- HY-113465A
-
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Endogenous Metabolite
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Inflammation/Immunology
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11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum .
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- HY-100838A
-
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mGluR
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Metabolic Disease
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L-CCG-I is an extended isomer of conformationally restricted glutamate analog. L-CCG-I also is a potent agonist for mGluR2 with an EC50 value of 0.3 nM. L-CCG-I can be used for the research of mGluR family .
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- HY-116392G
-
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Others
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Others
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D,L-erythro-PDMP is an erythro isomer of PDMP. D,L-erythro-PDMP causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase .
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- HY-116392H
-
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Others
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Others
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D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase .
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- HY-111226A
-
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Estrogen Receptor/ERR
Reactive Oxygen Species
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Cardiovascular Disease
Cancer
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(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM . GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma .
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- HY-130138B
-
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(5S,6R)-(11E)-DiHETE
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Others
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Inflammation/Immunology
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(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .
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- HY-141632
-
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Heptadecasphinganine
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Bacterial
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Infection
Neurological Disease
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Sphinganine-C17 (Heptadecasphinganine) is a synthetic bioactive sphingolipid and an isomer of sphinganine. Sphinganine-C17 inhibits the growth of Candida glabrata and Candida albicans with a minimum bactericidal concentration (MBC) of 0.5 μg/mL for both. Sphinganine-C17 can be used as an internal standard for the chromatographic analysis of sphingosine compounds .
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- HY-135163
-
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(5E)-Latanoprost; 5,6-trans-Latanoprost
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Prostaglandin Receptor
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Others
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trans-Latanoprost (5,6-trans-Latanoprost) is the trans isomer of Latanoprost (HY-B0577). trans-Latanoprost is promising for research of glaucoma and high eye pressure .
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- HY-129764A
-
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17-trans-PGF3α
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Others
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Inflammation/Immunology
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(17E)-Prostaglandin F3α (17-trans-PGF3α) is a double bond isomer of Prostaglandin F3α (HY-129764) and a potential metabolite of trans dietary fatty acids. (17E)-Prostaglandin F3α has anti-inflammatory activity .
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- HY-15078
-
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(R)-SPD502
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iGluR
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Neurological Disease
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NS1219 ((R)-SPD502) is the isomer of NS 1209 HY-15074. NS1209 is a selective AMPA receptor antagonist with neuroprotective activity. NS1209 can be used for the research of stroke, neuropathic pain and epilepsy .
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- HY-B1234A
-
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(E)-Octyl methoxycinnamate
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Estrogen Receptor/ERR
Androgen Receptor
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Endocrinology
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(E)-Octinoxate is the isomer of Octinoxate (HY-B1234). Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect .
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- HY-130317
-
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trans-δ2-11-Methyl-dodecenoic acid
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Fungal
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Infection
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trans-11-Methyl-2-dodecenic acid is a isomer of cis-11-Methyl-2-dodecenoic acid (HY-134215). cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems .
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- HY-113209A
-
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Endogenous Metabolite
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Metabolic Disease
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Ent-8-Iso-15(S)-prostaglandin F2α is an isomer of 8-Isoprostaglandin F2α, with a better inhibiting activity in the whole blood platelet aggregation inhibition assay .
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- HY-N8224A
-
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Others
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Others
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(E)-5-O-Cinnamoylquinic acid is the isomer of 5-O-Cinnamoylquinic acid. 5-O-Cinnamoylquinic acid is a co-pigment. 5-O-Cinnamoylquinic acid could form the stable blue solution to clarify the mechanism of blue sepal-color development of hydrangea .
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- HY-14147A
-
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(S)-BRL 24924
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5-HT Receptor
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Metabolic Disease
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(S)-Renzapride ((S)-BRL 24924) is the isomer of HY-14147 Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride also is a 5HT2b and 5HT3 receptor antagonist. Renzapride can be used for constipation predominant irritable bowel syndrome (C-IBS) study .
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- HY-100406
-
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(+)-MCPG
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mGluR
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Neurological Disease
|
|
(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371) . (S)-MCPG can be used for the study of the function of mGluRs in spatial learning .
|
-
- HY-125934
-
|
|
Others
|
Cancer
|
|
Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis, besides it is also a conjugate acid of allocholate and an isomer of cholic acid. Allocholic acid is a potent and specific stimulant of the adult olfactory system, it has a role as a marine metabolite, a rat metabolite and a human metabolite .
|
-
- HY-114558
-
|
Benzofuroline; Isathrine; Resmethrin(mixture of Isomers)
|
Others
|
Others
|
|
Resmethrin (Benzofuroline) is a reproductively toxic compound that inhibits spermatogenesis and induces apoptosis of germ cells in mouse testis culture in vitro, but has no significant toxicity to supporting cells and interstitial cells.
|
-
- HY-B0203B
-
|
(Rac)-R 065824
|
Adrenergic Receptor
NADPH Oxidase
|
Cardiovascular Disease
|
|
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
|
-
- HY-148516A
-
|
|
Myosin
|
Neurological Disease
|
|
(R)-MPH-220 is the R isomer of MPH-220 (HY-148516). MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness .
|
-
- HY-N2523
-
|
|
Wnt
|
Cancer
|
|
Gigantol isomer-1 is a bibenzyl compound derived from Dendrobium nobile. Gigantol isomer-1 shows promising therapeutic potential against cancer cells. Gigantol isomer-1 is a novel inhibitor of the Wnt/β-catenin pathway.
|
-
- HY-143940S
-
-
- HY-D1335
-
|
|
Fluorescent Dye
|
|
|
TAMRA amine, 5-isomer is an isomer of TAMRA, a xanthene dye with orange emission.
|
-
- HY-D1306
-
|
|
Fluorescent Dye
|
|
|
TAMRA azide, 6-isomer is an isomer of TAMRA, a xanthene dye with orange emission.
|
-
- HY-151774
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA hydrazide (6-isomer) is a click chemistry reagent that can be coupled to carbonyl compounds. The dye hydrazide in TAMRA hydrazide (6-isomer) labels carbonyl compounds such as aldehydes and ketones. TAMRA in TAMRA hydrazide (6-isomer) is a xanthene red fluorophore that reacts with terminal alkynes .
|
-
- HY-D0029
-
|
5(6)-AFM; Fluoresceinamine mixed Isomers
|
Fluorescent Dye
|
Others
|
|
5(6)-Aminofluorescein (5(6)-AFM) is a a precursor for synthesis of 5(6)-FITC (HY-15941). 5(6)-FITC is an amine-reactive derivative of fluorescein dye.
|
-
- HY-18719D
-
|
E-Endoxifen
|
Estrogen Receptor/ERR
|
Cancer
|
|
Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer exhibits antiestrogenic effects .
|
-
- HY-18719C
-
|
E-Endoxifen hydrochloride
|
Estrogen Receptor/ERR
|
Cancer
|
|
Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects .
|
-
- HY-100423A
-
|
KPT-8602 (Z-isomer)
|
CRM1
|
Cancer
|
|
Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602.
|
-
- HY-124535
-
|
|
PI3K
|
Cardiovascular Disease
|
|
TGX-115 is a cytopermeable and potent PI3-K isomer p110β/p110δ inhibitor (p110β IC50 value of 0.13 μM, p110δ IC50 value of 0.63 μM).TGX-115 is an enzyme that regulates platelet adhesion process and inhibits phosphoinosine 3-kinase. TGX-115 can be used in the study of cardiovascular diseases such as coronary artery occlusion, stroke, acute coronary syndrome, acute myocardial infarction, restenosis, arteriosclerosis and unstable angina .
|
-
- HY-10261E
-
|
(R)-BIBW 2992
|
EGFR
c-Met/HGFR
p38 MAPK
|
Cancer
|
|
(R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib (HY-10261) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
|
-
- HY-15615
-
|
ONC201 isomer
|
Others
|
Others
|
|
TIC10 isomer is the isomer of TIC10. TIC10 isomer does not possess the reported biological activity of inducing TRIAL expression.
|
-
- HY-151690
-
|
|
Fluorescent Dye
|
Others
|
|
FAM hydrazide, 6-isomer is a hydrazide derivative of fluorescein (FAM). FAM is a xanthene dye, a parent of fluorescein dye series. FAM hydrazide, 6-isomer can be used for the labeling of carbonyl compounds, aldehydes, and ketones .
|
-
- HY-132264
-
|
|
Fluorescent Dye
|
Others
|
|
FAM hydrazide, 6-isomer hydrochloride is a hydrazide derivative of fluorescein (FAM). FAM is a xanthene dye, a parent of fluorescein dye series. FAM hydrazide, 6-isomer hydrochloride can be used for the labeling of carbonyl compounds, aldehydes, and ketones .
|
-
- HY-B0203BS2
-
|
(Rac)-R 065824-d2,15N
|
NADPH Oxidase
Adrenergic Receptor
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
(Rac)-Nebivolol-d2, 15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
|
-
- HY-10388A
-
|
|
Calcium Channel
|
Others
|
|
TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca 2+ channel antagonist.
|
-
- HY-D1311
-
|
|
Fluorescent Dye
|
|
|
R110 azide, 6-isomer is an isomer of rhodamine dye with an azide group that labels DNA fragments. It enables visualization of the results of capillary electrophoresis genotyping experiments and gel shift experiments.
|
-
- HY-143921S
-
-
- HY-50752A
-
-
- HY-50752B
-
-
- HY-50752C
-
-
- HY-D1893
-
|
|
Fluorescent Dye
|
Others
|
|
HEX azide, 6-isomer, a derivate of fluorescent dye hexachlorofluorescein (HEX), can be used for labeling oligonucleotides .
|
-
- HY-100349A
-
|
(Z)-SU4312
|
PDGFR
VEGFR
|
Cancer
|
|
cis-SU4312 ((Z)-SU4312) inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. cis-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively. cis-SU4312 can cross blood brain barrier .
|
-
- HY-15940
-
|
5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed Isomers
|
Fluorescent Dye
|
Cancer
|
|
5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .
|
-
- HY-139066
-
|
Trichosanic acid
|
TNF Receptor
GLUT
Proteasome
Tau Protein
PKC
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
|
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .
|
-
- HY-114271A
-
-
- HY-114272A
-
-
- HY-W414549
-
|
|
Fluorescent Dye
|
Others
|
|
FAM alkyne, 6-isomer is a click chemistry regent that can be used in 1,3-dipolar cycloaddition with azido-labeled compound .
|
-
- HY-D1756
-
|
|
Fluorescent Dye
|
Others
|
|
ROX NHS ester, 6-isomer is a highly fluorescent, and photostable rhodamine dye for various applications. ROX labeled oligonucleotide probes are often used in qPCR, and qPCR instruments have ROX channel. This is reactive dye for the labeling of amino-groups in peptides, proteins, and amino-oligonucleotides. Pure single isomer.
|
-
- HY-15941
-
|
Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- Isomers
|
Fluorescent Dye
|
Others
|
|
5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .
|
-
- HY-18715
-
|
(S)-Ornidazole; Levornidazole
|
Bacterial
Parasite
|
Infection
|
|
Ornidazole Levo- is the levo-isomer of Ornidazole. Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Ornidazole Levo- is the less active isomer.
|
-
- HY-13233B
-
|
|
Dipeptidyl Peptidase
|
Others
|
|
Talabostat isomer mesylate is an isomer of talabostat mesylate. Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.
|
-
- HY-D1336
-
|
|
Fluorescent Dye
|
|
|
FAM amine, 6-isomer is a fluorescein derivative with an amine group and contains an isomer of the fluorophore. Can be used to modify biomolecules through enzymatic transamination. Its fatty amine groups can also react with electrophiles such as activated esters. The amine can also be conjugated to carbonyl compounds (aldehydes and ketones) by reductive amination.
|
-
- HY-15532B
-
|
MK-8776 S-isomer
|
Others
|
Cancer
|
|
SCH900776 S-isomer is the S-isomer of SCH900776. SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC50 of 3 nM.
|
-
- HY-114277B
-
|
AMG-510 isomer
|
Others
|
Others
|
|
Sotorasib (AMG-510) isomer is the less active isomer of Sotorasib (AMG-510). AMG-510 is a potent KRAS G12C covalent inhibitor.
|
-
- HY-D1900
-
|
|
Fluorescent Dye
|
Others
|
|
VIC azide, 6-isomer is a VIC derivative that can be used for conjugating VIC to other molecules. VIC can be used for labeling oligonucleotides at the 5’-end .
|
-
- HY-D1899
-
|
|
Fluorescent Dye
|
Others
|
|
VIC phosphoramidite, 6-isomer is a VIC derivative that can be used for conjugating VIC to other molecules. VIC can be used for labeling oligonucleotides at the 5’-end .
|
-
- HY-165037
-
|
MME; 1,2-Myristin-3-eicosapentaenoin; 14:0/14:0/20:5-TG
|
Others
|
Others
|
|
1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol (MME) is a compound that is studied as a triglyceride isomer in algae, and its isomer ratio changes with culture temperature.
|
-
- HY-167934
-
|
|
Others
|
Neurological Disease
|
|
Isomer-CM 352 is a new antifibrinolytic agent with inhibitory activity against matrix metalloproteinases. Isomer-CM 352 effectively reduced hematoma expansion and promoted functional and neurological recovery in a model of intracerebral hemorrhage. Isomer-CM 352 improved neurological function by preventing hematoma growth and showed potential in the suppression of acute neurological diseases .
|
-
- HY-N2543
-
|
(E/Z)-Damascenone
|
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Damascenone ((E/Z)-Damascenone) is an active compound of?Epipremnum pinnatum with anti-inflammatory activity . Damascenone is a mixture complex of?E-isomer-Damascenone and Z-isomer Damascenone.
|
-
- HY-139586C
-
|
MK-1454 (isomer 3)
|
STING
|
Cancer
|
|
Ulevostinag (isomer 3) (example 246) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (isomer 3) plays an important role in anti-tumor research .
|
-
- HY-N4072
-
|
|
Others
|
Metabolic Disease
|
|
6''-O-Acetylglycitin, a acetyl glucoside, is one of the isoflavone isomer in soybeans, shows various extents of content reduction dependent on storage temperature, packaging condition, and its isoflavone isomer kind .
|
-
- HY-15937
-
|
5(6)-Carboxyfluorescein N-hydroxysuccinimide ester; 5(6)-Carboxyfluorescein succinimidyl ester mixed Isomers
|
Fluorescent Dye
|
Others
|
|
5(6)-FAM SE is a green fluorescent dye widely used for protein labeling.
|
-
- HY-151857
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA azide, 5-isomer is a click chemical containing azide groups that can be used as a linker for the orange dye TAMRA. The azide group of TAMRA Azide, 5-isomer enables copper-catalyzed click chemical reactions with alkynes, DBCO, and BCN . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-101140A
-
-
- HY-15939
-
-
- HY-113026
-
-
- HY-141877B
-
|
YS43-22 (isomer)
|
PROTACs
|
Cancer
|
|
MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a potent and selective PRMT5 (protein arginine methyltransferase 5) degrader, and inhibits growth of multiple cancer cell lines .
|
-
- HY-113691
-
|
|
Lipoxygenase
|
Others
|
|
(E)-L-652343 is a compound with potent cyclooxygenase and 5-lipoxygenase inhibitory activity. (E)-L-652343 can effectively inhibit the synthesis of products of these two pathways in vivo. (E)-L-652343 showed high sensitivity and specificity in the detection of geometric isomers in canine and human plasma. (E)-L-652343 showed selective metabolism in vivo, and the elimination rate of the E isomer was faster than that of the Z isomer .
|
-
- HY-151680
-
|
|
DNA Stain
|
Others
|
|
TAMRA alkyne, 6-isomer is a linker of TAMRA which is a xanthene dye with orange emission that is commonly used for oligonucleotide labeling and amino acid sequencing. The addition of the alkyne groups allows for it to be reacted with an azide for copper-catalyzed Click Chemistry .
|
-
- HY-129257
-
|
|
Others
|
Others
|
|
Esfenvalerate is one of the four isomers of the pyrethroid insecticide fenvalerate .
|
-
- HY-18719
-
|
|
Estrogen Receptor/ERR
Potassium Channel
|
Cancer
|
|
Endoxifen Z-isomer is the most important Tamoxifen metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC50 value of 1.6 μM.
|
-
- HY-N2543R
-
|
|
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Damascenone (Standard) is the analytical standard of Damascenone. This product is intended for research and analytical applications. Damascenone ((E/Z)-Damascenone) is an active compound of Epipremnum pinnatum with anti-inflammatory activity . Damascenone is a mixture complex of E-isomer-Damascenone and Z-isomer Damascenone.
|
-
- HY-124143
-
-
- HY-B1617A
-
|
|
Estrogen Receptor/ERR
|
Metabolic Disease
Endocrinology
|
|
Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent .
|
-
- HY-W018772S16
-
|
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
D-Ribose-1,2- 13C2 is the 13C labled D-Ribose(mixture of isomers) (HY-W018772) . D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .
|
-
- HY-101339
-
|
|
Others
|
Others
|
|
(R)-RS 56812 is a 5-HT3 receptor antagonist that enhances performance in monkeys on a delayed matching task. The (R) isomer produces more systematic improvements than the (S) isomer and has potential inhibitory effects in diseases involving cognitive decline.
|
-
- HY-101339A
-
|
|
Others
|
Others
|
|
(R)-RS 56812 hydrochloride is a 5-HT3 receptor antagonist that enhances performance in monkeys on a delayed matching task. The (R) isomer produces more systematic improvements than the (S) isomer and has potential inhibitory effects in diseases involving cognitive decline.
|
-
- HY-101648
-
-
- HY-N10543A
-
|
|
Others
|
Others
|
|
3-p-Coumaroylquinic acid (compound 3a) is an isomer of p-coumaroylquinic acid .
|
-
- HY-136968
-
-
- HY-114552
-
-
- HY-114061
-
|
|
Others
|
Others
|
|
(R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P1,3,4,5 than (S)-Isomer (HY-15382) .
|
-
- HY-148696B
-
|
|
Others
|
Others
|
|
Gly-(S)-Cyclopropane-Exatecan is the isomer of Gly-Cyclopropane-Exatecan (HY-148696A).
|
-
- HY-101804
-
-
- HY-N0886
-
Aloin B
2 Publications Verification
Aloin-B; Isobarbaloin
|
Others
|
Others
|
|
Aloin B is one isomer of Aloin; Aloin is a physiologically active anthraquinone present in aloe.
|
-
- HY-100615A
-
-
- HY-101629
-
|
|
Others
|
Neurological Disease
|
|
(E)-Crotylbarbital is the isomer of Crotylbarbital. Crotylbarbital is a barbiturate derivative and can be used for the research of insomnia.
|
-
- HY-124909
-
-
- HY-W093104
-
-
- HY-76542A
-
|
5,6-trans-Ergocalciferol; 5,6-trans-Calciferol; 5,6-trans-Ercalciol
|
Others
|
Others
|
|
5,6-trans-Vitamin D2 is the isomer of Vitamin D2 .
|
-
- HY-P2855
-
-
- HY-125784A
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
(R)-Viloxazine hydrochloride is a less active R-isomer of Viloxazine hydrochloride. Viloxazine hydrochloride is an effective antidepressant agent .
|
-
- HY-120935
-
-
- HY-40135
-
|
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
|
Endogenous Metabolite
|
Others
|
|
L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
|
-
- HY-W010098
-
|
|
Endogenous Metabolite
|
Others
|
|
Terephthalic acid is one isomer of the three phthalic, a precursor to the polyester PET, used to make clothing and plastic bottles.
|
-
- HY-132475S
-
-
- HY-105559
-
|
Quinotoxine
|
Others
|
Cardiovascular Disease
|
|
Viquidil (Quinotoxine), an isomer of Quinidine, is a cerebral vasodilator agent. Viquidil shows antithrombotic activity .
|
-
- HY-N7259
-
|
|
Others
|
Neurological Disease
|
|
(+)-Isomenthone is an isomenthone isolated from Ziziphora clinopodioides Lam.. (+)-Isomenthone is an isomer of L-Menthone .
|
-
- HY-105559A
-
|
Quinotoxine hydrochloride
|
Others
|
Cardiovascular Disease
|
|
Viquidil hydrochloride (Quinotoxine hydrochloride), an isomer of Quinidine, is a cerebral vasodilator agent. Viquidil hydrochloride shows antithrombotic activity .
|
-
- HY-131253
-
|
|
Drug Metabolite
|
Others
|
|
Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM .
|
-
- HY-N10830
-
|
|
Others
|
Infection
|
|
(±)-Nirtetralin is an isomer of Nirtetralin, which inhibits growth of hepatitis E virus (HEV) in HepaRG cells .
|
-
- HY-145580A
-
|
(S)-UCB0599; (S)-NPT200-11
|
α-synuclein
|
Neurological Disease
|
|
(S)-Minzasolmin is an isomer of minzasolmin (HY-145580), an inhibitor of α-synuclein oligomerization .
|
-
- HY-129756
-
|
N-Phenylthioacetamide
|
Biochemical Assay Reagents
|
Others
|
|
Thioacetanilide (N-Phenylthioacetamide) is a thioderivative of acetanilide that exhibits Z/E isomer preference and solvent dependence .
|
-
- HY-15805A
-
|
|
Others
|
Others
|
|
cis-KIN-8194 is the cis-isomer of KIN-8194 (HY-15805)
|
-
- HY-50674A
-
|
|
CCR
|
Inflammation/Immunology
|
|
INCB3344 R-isomer is the R-isomer of INCB3344. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity .
|
-
- HY-66021
-
6-FAM
1 Publications Verification
6-Carboxyfluorescein
|
Fluorescent Dye
|
Others
|
|
6-FAM (6-Carboxyfluorescein) is an isomer of carboxyfluorescein and is mainly used for sequencing and labeling of nucleic acids.
|
-
- HY-101704
-
-
- HY-76082
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
|
-
- HY-19487A
-
|
Ribocil S enantiomer; ent-Ribocil A
|
Bacterial
|
Infection
|
|
Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN) with a KD of 6.6 nM.
|
-
- HY-N0557
-
|
|
Others
|
Cancer
|
|
Isoescin IB is an isomer of Escin IB. Isoescin IB and Escin IB are the chief active ingredients in escin .
|
-
- HY-N2519
-
|
(E)-Laricin
|
Fungal
|
Infection
|
|
(E)-Coniferin is the isomer of Coniferin. Coniferin is a glucoside of coniferyl alcohol. Coniferin inhibits fungal growth and melanization .
|
-
- HY-131266
-
|
|
Drug Metabolite
|
Others
|
|
Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM .
|
-
- HY-14735
-
|
XP 19986
|
GABA Receptor
|
Neurological Disease
|
|
Arbaclofen placarbil is a novel transported proagent of the active R-isomer of baclofen. Baclofen is a racemic GABAB receptor agonist
|
-
- HY-D1774
-
-
- HY-111156
-
|
|
Monoamine Oxidase
|
Neurological Disease
|
|
NW-1172 (free base) (compound 22b) is a 5-HT3 receptor antagonist with performance-enhancing activity in a delayed matching task in monkeys, with the (R) isomer producing more systematic improvements than the (S) isomer, a difference paralleled by the higher affinity of the (R) enantiomer for the 5-HT3 receptor.
|
-
- HY-B1583
-
|
Zucapsaicin; Civamide; cis-Capsaicin
|
TRP Channel
HSV
|
Neurological Disease
|
|
(Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.
|
-
- HY-W009749B
-
|
|
Others
|
Others
|
|
DL-Cystathionine dihydrochloride is a mixture of 4 isomers of cystathionine and allocystathionine. DL-Cystathionine dihydrochloride also is an intermediate in the biosynthesis of amino acid cysteine .
|
-
- HY-78139
-
|
L-(-)-Xylose
|
Others
|
Others
|
|
L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type .
|
-
- HY-121305A
-
-
- HY-W009749A
-
|
|
Others
|
Others
|
|
DL-Cystathionine is a mixture of 4 isomers of cystathionine and allocystathionine. DL-Cystathionine also is an intermediate in the biosynthesis of amino acid cysteine .
|
-
- HY-12170B
-
|
(R)-AG3340; (R)-KB-R9896
|
Others
|
Cancer
|
|
(R)-Prinomastat ((R)-AG3340) is the R-isomer of Prinomastat (HY-12170) (a MMP Inhibitor) .
|
-
- HY-167662
-
|
|
Others
|
Others
|
|
Sopromidine is a potent and stereoselective isomer of the achiral H2-agonist Impromidine (HY-116777) .
|
-
- HY-B1617AS1
-
|
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
Zuclomiphene-d5 (citrate) is the deuterium labeled Zuclomiphene citrate[1]. Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[2][3][4][5].
|
-
- HY-N2341
-
|
9-trans-Hexadecenoic acid; trans-Palmitoleic acid
|
AMPK
PPAR
Glucokinase
|
Metabolic Disease
|
|
Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
|
-
- HY-Y0079
-
|
|
Endogenous Metabolite
|
Others
|
|
D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014 .
|
-
- HY-130573
-
|
Dimethylallyl diphosphate
|
Others
|
Metabolic Disease
|
|
DMAPP (Dimethylallyl pyrophosphate) is an isoprenoid precursor. DMAPP, as an isomer of isopentenyl pyrophosphate (IPP), exists in virtually all life forms .
|
-
- HY-19654C
-
|
(1S,5R)-GSK598809 hydrochloride
|
Dopamine Receptor
|
Neurological Disease
|
|
(-)-GSK598809 is an isomer of GSK598809. GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist.
|
-
- HY-152943A
-
|
(Rac)-EP-0035985
|
Mitophagy
|
Cancer
|
|
(Rac)-MTK458 (compound 16) is an activator of mitophagy. EP-0035985 is the isomer of EP-0035985 .
|
-
- HY-132809B
-
|
(Rac)-CIN-107
|
Others
Drug isomer
|
Endocrinology
|
|
(Rac)-Baxdrostat is the isomer of Baxdrostat (HY-132809), and can be used as an experimental control. Baxdrostat is a aldosterone synthase inhibitor .
|
-
- HY-167168
-
|
|
Calcium Channel
|
Cardiovascular Disease
|
|
(S)-Azelnidipine is a calcium channel (Calcium Channel) blocker and the S-isomer of Azelnidipine, with potential for use in cardiovascular disease research .
|
-
- HY-14855A
-
|
(S)-TR 700; (S)-DA 7157
|
Bacterial
Antibiotic
|
Infection
|
|
(S)-Tedizolid is the S-enantiomer of Tedizolid. Tedizolid is a novel oxazolidinone with activity against Gram-positive pathogens. (S)-Tedizolid is the less active isomer.
|
-
- HY-113362
-
|
|
Endogenous Metabolite
|
Others
|
|
Petroselinic acid, a positional isomer of oleic acid, is isolated from the vegetable oil of Coriandrum sativum fruits. Petroselinic acid is used as substrate for sophorolipid fermentation .
|
-
- HY-B1674
-
-
- HY-W016814
-
|
cis-Aconitic acid
|
Endogenous Metabolite
|
Others
|
|
(Z)-Aconitic acid (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
|
-
- HY-41656
-
|
(-)-Praziquanamine
|
Others
|
Others
|
|
D-Praziquanamine is the isomer of L-Praziquanamine (HY-N1765), and can be used as an experimental control. L-Praziquanamine is a natural product.
|
-
- HY-151481A
-
|
|
FXR
|
Neurological Disease
|
|
β-FXR antagonist 1 (C 12), an isomer of FXR antagonist 1 (HY-151481) is a FXR antagonist .
|
-
- HY-160220S
-
|
|
Ras
|
Cancer
|
|
KRAS inhibitor-23 (Isomer 2 of compound i) is a potent inhibitor of KRAS that plays an important role in cancer research .
|
-
- HY-130658
-
-
- HY-18600B
-
-
- HY-D1314
-
|
6-FAM azide
|
Fluorescent Dye
|
Others
|
|
FAM azide, 6-isomer (6-FAM azide), a fluorescent dye, is a click chemistry reagent containing an azide group . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-N6008A
-
|
7R-O-methylmorroniside
|
Others
|
Others
|
|
7β-O-Methylmorroniside (7R-O-methylmorroniside) is a R-isomer of 7-O-Methyl morroniside .
|
-
- HY-10502A
-
|
IND-58359 S enantiomer; (S)-(-)-R-115777
|
Farnesyl Transferase
|
Cancer
|
|
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.
|
-
- HY-Y0017
-
-
- HY-I1060
-
|
(3R)-LS-Isoleucine; L-Allo-isoleucine
|
Endogenous Metabolite
|
Others
|
|
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).
|
-
- HY-16950B
-
|
(E)-Afimoxifene
|
Estrogen Receptor/ERR
|
Cancer
|
|
(E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator.
|
-
- HY-100443B
-
|
(-)-PX-102 (trans isomer); (-)-PX-104
|
FXR
Autophagy
|
Metabolic Disease
|
|
(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.
|
-
- HY-130573A
-
|
Dimethylallyl diphosphate triammonium
|
Others
|
Metabolic Disease
|
|
DMAPP (Dimethylallyl diphosphate) triammonium is an isoprenoid precursor. DMAPP triammonium, as an isomer of isopentenyl pyrophosphate (IPP), exists in virtually all life forms .
|
-
- HY-134211
-
|
|
Endogenous Metabolite
|
Others
|
|
Z-2-Octenoic acid is the Z-isomer of 2-Octenoic acid. trans-2-Octenoic acid is a metabolite of Mucor species.
|
-
- HY-129257R
-
|
|
Others
|
Others
|
|
Esfenvalerate (Standard) is the analytical standard of Esfenvalerate. This product is intended for research and analytical applications. Esfenvalerate is one of the four isomers of the pyrethroid insecticide fenvalerate .
|
-
- HY-139149A
-
|
|
Histone Acetyltransferase
|
Cancer
|
|
(E/Z)-NiCur is the active isomer of NiCur (HY-139149). (E/Z)-NiCur is a potent CBP histone acetyltransferase (HAT) inhibitor .
|
-
- HY-153692A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(R)-WRN inhibitor 1 is the R-isomer of WRN inhibitor 1 (example 7). WRN inhibitor 1 is a WRN inhibitor with anticancer activity .
|
-
- HY-D0723
-
|
5(6)-Carboxytetramethylrhodamine N-succinimidyl ester
|
DNA Stain
|
Others
|
|
5(6)-TAMRA SE is the amine-reactive, mixed isomer form of TAMRA, which is a dye for oligonucleotide labeling and automated DNA sequencing applications.
|
-
- HY-12993A
-
|
A-60444 racemate
|
RSV
|
Others
|
|
RSV604 (A-60444) racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer.
|
-
- HY-W010589
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
|
-
- HY-112895A
-
|
|
Androgen Receptor
|
Cancer
|
|
(R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer .
|
-
- HY-114072A
-
-
- HY-W589849
-
|
FITC Isomer Ⅱ
|
Biochemical Assay Reagents
|
Others
|
|
6-Isothiocyanato-Fluorescein (FITC Isomer Ⅱ) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-112504D
-
|
|
Others
|
Cancer
|
|
(R)-INCB054329 is the isomer of INCB054329 (HY-112504), and can be used as an experimental control. INCB054329 is a potent BET inhibitor.
|
-
- HY-126028
-
|
(R)-Sotalol
|
Potassium Channel
|
Cardiovascular Disease
|
|
(-)-Sotalol ((R)-Sotalol) is the R-isomer of Sotalol. (-)-Sotalol is a hERG inhibitor, with a Kd of 0.60 μM. (-)-Sotalol can be used for the research of cardiac arrhythmias .
|
-
- HY-N12905
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Celastramycin A isomer is an isomer of Celastramycin A (HY-122292), an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 μg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-α pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL .
|
-
- HY-153816A
-
|
|
Others
|
Others
|
|
(1R)-GLP-1 receptor agonist 12 is the isomer of GLP-1 receptor agonist 12 (HY-153816) .
|
-
- HY-13258
-
|
|
Ephrin Receptor
|
Cancer
|
|
NVP-BHG712 isomer, a regioisomer of NVP-BHG712, shows conserved non-bonded binding to EPHA2 and EPHB4 .
|
-
- HY-12495
-
-
- HY-116790A
-
|
(R)-Penbutolol; (+)-Isopenbutolol
|
Adrenergic Receptor
|
Metabolic Disease
Endocrinology
|
|
(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM . (+)-Penbutolol is an optical isomer of l-penbutolol with Na + channel-blocking action .
|
-
- HY-103035
-
|
|
Phosphodiesterase (PDE)
|
Cancer
|
|
BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC50: 1 nM), extracted from the patent US20170158687A1 .
|
-
- HY-N0121A
-
|
|
Others
|
Others
|
|
(-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis .
|
-
- HY-76688
-
|
(Rac)-ARQ 197; (Rac)-ARQ 198
|
Others
c-Met/HGFR
|
Cancer
|
|
(Rac)-Tivantinib is the isomer of Tivantinib (HY-50686), and can be used as an experimental control. Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM.
|
-
- HY-14778A
-
|
(S)-GSK 221149; (S)-GSK 221149A
|
Others
|
Neurological Disease
Endocrinology
|
|
(S)-Retosiban is the isomer of Retosiban (HY-14778), and can be used as an experimental control. Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.
|
-
- HY-17626C
-
|
(R)-WCK-2349
|
Others
|
Others
|
|
(R)-Alalevonadifloxacin mesylate is an isomer of Alalevonadifloxacin mesylate (HY-17626B). Alalevonadifloxacin mesylate is a oraly active anti-methicillin-resistant Staphylococcus aureus (MRSA) antibiotic .
|
-
- HY-115726A
-
|
|
γ-secretase
|
Neurological Disease
|
|
(-)-FRM-024 is the (-)-isomer of FRM-024, a potent CNS-penetrant gamma secretase modulator that can be utilized in Alzheimer’s disease research .
|
-
- HY-139124
-
|
15(R)-Carboprost; 15(R)-15-methyl PGF2α
|
Others
|
Metabolic Disease
|
|
15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.
|
-
- HY-103641
-
|
(2R)-Octyl-2-HG
|
Others
|
Cancer
|
|
(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.
|
-
- HY-W010098S
-
-
- HY-N2064
-
|
|
mAChR
|
Neurological Disease
|
|
Racanisodamine is one of the racemic isomers of anisodamine, resembles anisodamine in pharmacological effect. Racanisodamine is a non-selective muscarinic antagonist, used as a component of eye drops for myopic control .
|
-
- HY-103641A
-
|
(2S)-Octyl-2-HG
|
Others
|
Cancer
|
|
(2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate.
|
-
- HY-124141
-
|
trans-9-Tetradecenoic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Myristelaidic acid (trans-9-Tetradecenoic acid), a 14-carbon trans fatty acid, is the trans isomer of Myristoleic acid. Myristelaidic acid is found in most animal fats .
|
-
- HY-N0326S7
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Methionine-d3 is the deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-N0326S8
-
-
- HY-N0326S10
-
-
- HY-151224
-
|
|
Others
|
Others
|
|
Thermospermine, a structural isomer of Spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5). Thermospermine suppresses auxin-inducible xylem differentiation in Arabidopsis thaliana .
|
-
- HY-113102A
-
|
|
Endogenous Metabolite
|
Cancer
|
|
9(E),11(E)-Octadecadienoic acid is an isomer of conjugated linoleic acid (CLA). Conjugated linoleic acid is a fatty acid with potentially beneficial physiological and anticarcinogenic effects .
|
-
- HY-113336A
-
|
|
Others
|
Others
|
|
15(R)-HETE is an isomer of 15-HETE. 15-HETE is a lipid mediator derived from arachidonic acid and can be used for the study of asthma .
|
-
- HY-113026R
-
-
- HY-N0886R
-
|
|
Others
|
Others
|
|
Aloin B (Standard) is the analytical standard of Aloin B. This product is intended for research and analytical applications. Aloin B is an isomer of aloin, a physiologically active anthraquinone compound in aloe.
|
-
- HY-105109B
-
|
|
Others
|
Neurological Disease
|
|
(S)-Cilansetron is the S-isomer of Cilansetron. Cilansetron is a 5-HT3 receptor antagonist that can be used in research related to irritable bowel syndrome .
|
-
- HY-112019
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Methionine- 34S is a 34S-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-N7731A
-
|
(R)-Lavandulol
|
Others
|
Others
|
|
(-)-Lavandulol is the isomer of (±)-Lavandulol (HY-N7731). (±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .
|
-
- HY-18719A
-
|
|
Estrogen Receptor/ERR
Potassium Channel
|
Cancer
|
|
Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).
|
-
- HY-B1453
-
|
DL-Carnitine chloride
|
Reactive Oxygen Species
|
Metabolic Disease
|
|
(±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.
|
-
- HY-N0351S
-
|
|
Endogenous Metabolite
|
Cancer
|
|
p-Coumaric acid- 13C3 is the 13C-labeled p-Coumaric acid. p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities.
|
-
- HY-W010098S1
-
-
- HY-N0326S
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Methionine- 15N is the 15N-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-124414S
-
-
- HY-N1400
-
|
|
Others
|
Cancer
|
|
(20R)-Ginsenoside Rh1, the R isomer of Ginsenoside Rh1 isolated from Panax Ginseng, inhibits the thrombin-induced conversion of fibrinogen to fibrin .
|
-
- HY-13851
-
|
|
PDK-1
|
Others
|
|
PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48 .
|
-
- HY-N0326S3
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Methionine- 13C is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-40135S
-
-
- HY-D1576
-
|
|
Fluorescent Dye
|
Others
|
|
C6 NBD L-threo-dihydroceramide is a dihydro-ceramide isomer labeled with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD), can be used to detect ceramide.
|
-
- HY-14971A
-
|
AKTIV
|
Akt
|
Cancer
|
|
Akt inhibitor-IV (AKTIV) acts as a PI3K-Akt inhibitor at the E isomer (HY-14971), with potent cytotoxicity .
|
-
- HY-N1418A
-
|
(+)-Canadine; (R)-(+)-Canadine
|
Others
|
Inflammation/Immunology
|
|
(R)-(+)-Tetrahydroberberine is the isomer of (S)-(-)-Tetrahydroberberine (HY-N1418), and can be used as an experimental control. (S)-(-)-Tetrahydroberberine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity .
|
-
- HY-W008086A
-
|
|
Others
|
Others
|
|
(Rac)-H-Thr-OMe hydrochloride is the isomer of H-Thr-OMe hydrochloride (HY-W008086), and can be used as an experimental control. H-Thr-OMe.HCl is a threonine derivative .
|
-
- HY-15278A
-
|
(16R)-KOS 862
|
Others
Microtubule/Tubulin
|
Infection
Cancer
|
|
(16R)-Epothilone D is the isomer of Epothilone D (HY-15278), and can be used as an experimental control. Epothilone D (KOS 862) is a potent microtubule stabilizer.
|
-
- HY-116152A
-
|
(S)-Ciprofol; (S)-HSK3486
|
GABA Receptor
|
Neurological Disease
|
|
(S)-Cipepofol is the isomer of Cipepofol (HY-116152).Cipepofol (HSK3486) is a sleep-promoting active molecule and a gamma-aminobutyric acid (GABA) receptor enhancer .
|
-
- HY-121677
-
|
|
Others
|
Others
|
|
Norgestomet is a compound with progesterone receptor agonist activity. The synthetic product has high purity and agonist activity on the progesterone receptor, while its 17β-isomer is inactive.
|
-
- HY-120955
-
|
|
Others
|
Others
|
|
Cloprostol, a synthetic derivative of prostaglandin F2α, is used as an ossified in veterinary medicine and the research of reproductive disorders in cattle, pigs and horses. (+)-5-trans Cloprostenol is a secondary impurity produced during the synthesis of (+) -cloprostenol .
|
-
- HY-108560A
-
|
|
Prostaglandin Receptor
|
Others
|
|
15(S)-Fluprostenol is the isomer of (+)-Fluprostenol (HY-108560). (+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1) .
|
-
- HY-15464D
-
|
(S)-(+)-Gossypol acetic acid
|
Bcl-2 Family
|
Cancer
|
|
(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
|
-
- HY-113334
-
-
- HY-W002272
-
|
|
Nucleoside Antimetabolite/Analog
|
Others
|
|
Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA .
|
-
- HY-N0363
-
|
(S)-Columbianetin
|
Fungal
|
Infection
Inflammation/Immunology
|
|
(+)-Columbianetin is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity .
|
-
- HY-W016781
-
|
H-D-Arg-OH
|
Endogenous Metabolite
|
Others
|
|
D-arginine (H-D-Arg-OH) is the D-isomer of arginine. Arginine is an α-amino acid that is used in the biosynthesis of proteins. D-Arginine is an inactive form of L-arginine .
|
-
- HY-N8084
-
|
|
Others
|
Others
|
|
Epimedin B1 is initially isolated from E. Wushanense and is a Chemical marker of E. sagittatum in agent Yin-Yang-Huo. Epimedin B1 is the isomer of Epimedin B .
|
-
- HY-N1966
-
|
|
p38 MAPK
JNK
ERK
|
Neurological Disease
|
|
(E)-Osmundacetone is the isomer of Osmundacetone. Osmundacetone significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases. Osmundacetone has a neuroprotective effect against oxidative stress .
|
-
- HY-19414A
-
-
- HY-N0326S5
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Methionine- 13C5 is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-148718
-
|
|
Others
|
Neurological Disease
|
|
4-Chloro Trazodone hydrochloride is an isomer of Trazodone hydrochloride (HY-B0478). Trazodone hydrochloride is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders .
|
-
- HY-N0137A
-
|
|
Others
|
Neurological Disease
|
|
(R)-Tetrahydropapaverine hydrochloride is the isomer of Tetrahydropapaverine hydrochloride (HY-N0137), and can be used as an experimental control. Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons .
|
-
- HY-W012888
-
|
(-)-Leucinol
|
Others
|
Others
|
|
D-Leucinol is the isomer of L-Leucinol (HY-W015876), and can be used as an experimental control. L-Leucinol ((+)-Leucinol) is a competitive aminopeptidase inhibitor with Ki value of 17 μM .
|
-
- HY-103029
-
|
|
Wee1
|
Cancer
|
|
Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively .
|
-
- HY-119536
-
|
|
Others
|
Neurological Disease
|
|
Sufentanil is a potent synthetic opioid analgesic. Norsufentanil, a metabolite of sufentanil, is produced by the oxidative N-dealkylation of the liver cytochrome P450 isomer. Norsufentanil has analgesic activity .
|
-
- HY-W654232
-
|
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid-d4
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
L-Hydroxyproline-d4 is deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals .
|
-
- HY-167922
-
|
|
Others
|
Neurological Disease
|
|
(R,R,S)-GAT107 is a fully agonistic positive modulator of α7 nicotinic receptors with significant biological activity. Its activity is entirely present in its (+)-isomer 1b, while (-)-isomer 1a does not affect its activity when used together. Studies have shown that (R,R,S)-GAT107 is the most potent ago-PAM for α7 nicotinic receptors currently known and has the potential for further in vivo evaluation .
|
-
- HY-N0471
-
|
Hyoscyamine
|
mAChR
|
Neurological Disease
|
|
L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .
|
-
- HY-B1674S
-
|
DL-Leucine-d10; (RS)-Leucine-d10
|
Endogenous Metabolite
Bacterial
|
Metabolic Disease
|
|
(±)-Leucine-d10 is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%[1].
|
-
- HY-N2341S
-
|
|
AMPK
PPAR
Glucokinase
|
Metabolic Disease
|
|
Palmitelaidic acid-d13 is the deuterium labeled Palmitelaidic Acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
|
-
- HY-N0363A
-
|
(S)-Columbianetin acetate
|
Fungal
|
Infection
Inflammation/Immunology
|
|
(S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity .
|
-
- HY-W067479
-
|
|
Others
|
Others
|
|
(E)-Cinnamamide, the less active isomer of Cinnamamide. Cinnamamide, a derivative of the plant secondary compound Cinnamic acid. Cinnamamide is effective as a non-lethal chemical repellent suitable for reducing avian pest damage .
|
-
- HY-116459
-
|
AF102A hydrochloride
|
mAChR
|
Neurological Disease
|
|
Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease .
|
-
- HY-N0326S4
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Methionine-1- 13C is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-135715
-
|
|
Others
|
Others
|
|
(E)-UK122 TFA is the isomer of UK122 TFA. UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM .
|
-
- HY-76082S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
L-Pyroglutamic acid-d5 is the deuterium labeled L-Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
|
-
- HY-B1674S4
-
-
- HY-N11636
-
|
|
Apoptosis
|
Cancer
|
|
Ganoderic acid S is a positional isomer of ganoderic acids, that can be isolated from the fermented mycelia of Ganoderma lucidum. Ganoderic acid S can induce apoptosis in HeLa cells through the mitochondria pathway .
|
-
- HY-10480A
-
|
(R)-TAK-875
|
Free Fatty Acid Receptor
|
Metabolic Disease
|
|
(R)-Fasiglifam is the isomer of Fasiglifam (HY-10480), and can be used as an experimental control. Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.
|
-
- HY-W010098R
-
|
|
Endogenous Metabolite
|
Others
|
|
Terephthalic acid (Standard) is the analytical standard of Terephthalic acid. This product is intended for research and analytical applications. Terephthalic acid is one isomer of the three phthalic, a precursor to the polyester PET, used to make clothing and plastic bottles .
|
-
- HY-113943
-
|
|
Endogenous Metabolite
|
Others
|
|
9(S)-HETE is the S isomer of 9-HETE (HY-113943A). 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .
|
-
- HY-118364
-
|
|
RAR/RXR
|
Metabolic Disease
|
|
AGN 190727 is a structural isomer of AGN 190121 and has no activating effect on RAR/RXR. AGN 190121 is a RAR-specific agonist that causes a dose-dependent increase in serum triglycerides, leading to hypertriglyceridemia.
|
-
- HY-N1394S
-
-
- HY-N5056
-
|
|
Influenza Virus
|
Others
|
|
DL-Goitrin, also called (R, S)- report by the spring, consists of the epigoitrin (reported by the R- Spring) and the spring (-S- reported by spring), and the two mutually isomers, and the mixture is the ingredient of cruciferous vegetables .
|
-
- HY-W013291A
-
|
|
Others
|
Others
|
|
H-D-Asp(OtBu)-OtBu·HCl is the isomer of H-Asp(OtBu)-OtBu.HCl (HY-W013291), and can be used as an experimental control. H-Asp(OtBu)-OtBu.HCl is an aspartic acid derivative .
|
-
- HY-N1394R
-
|
4-Methoxybenzoic acid (Standard); Draconic acid (Standard)
|
Endogenous Metabolite
Bacterial
|
Infection
|
|
p-Anisic acid (Standard) is the analytical standard of p-Anisic acid. This product is intended for research and analytical applications. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties .
|
-
- HY-N0471C
-
|
Daturine sulfate hydrate
|
mAChR
|
Neurological Disease
|
|
L-Hyoscyamine sulfate hydrate, a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate hydrate is a levo-isomer to Atropine (HY-B1205) .
|
-
- HY-40135R
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Hydroxyproline (Standard) is the analytical standard of L-Hydroxyproline. This product is intended for research and analytical applications. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
|
-
- HY-129436
-
-
- HY-N14990
-
|
|
Fungal
|
Infection
|
|
Pneumocandin C0 is the isomer of Pneumocandin B0 (HY-17578) with antifungal activity, which is found by carrying out fermentations of Glarea lozoyensis at a high residual fructose concentration .
|
-
- HY-19654B
-
|
(1S,5R)-GSK598809
|
Dopamine Receptor
|
Others
|
|
(-)-GSK598809 ((1S,5R)-GSK598809) is an isomer of GSK598809. GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist.
|
-
- HY-129770
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-methionine sulfoxide is the D-isomer of Methionine sulfoxide. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins , which is easily oxidized during the course of storage or processing .
|
-
- HY-129770A
-
|
|
Others
|
Metabolic Disease
|
|
D-methionine sulfoxide hydrochloride is the D-isomer of Methionine sulfoxide hydrochloride. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins, which is easily oxidized during the course of storage or processing .
|
-
- HY-107330
-
|
|
Antibiotic
|
Others
|
|
(6R,7S)-Cefminox sodium heptahydrate is an isomer of Cefminox sodium heptahydrate. Cefminox sodium heptahydrate is a β-lactam cephalosporin antibiotic, which exhibits a broad spectrum of antibacterial activity .
|
-
- HY-N0326S1
-
-
- HY-N0326S2
-
-
- HY-Y0079S
-
|
|
Endogenous Metabolite
|
Others
|
|
D-Phenylalanine-d5 is the deuterium labeled D-Phenylalanine. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014[1].
|
-
- HY-Y0079S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
D-Phenylalanine-d8 is the deuterium labeled D-Phenylalanine. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014[1].
|
-
- HY-145806
-
|
13-cis-Retinol acetate; 13-cis-Vitamin A acetate
|
Endogenous Metabolite
|
Endocrinology
|
|
13-cis-Retinyl acetate (13-cis-Retinol acetate; 13-cis-Vitamin A acetate) is a 13-cis isomer formed by Retinyl acetate. 13-cis-Retinyl acetate is an active metabolite of vitamin A .
|
-
- HY-133681A
-
|
|
Others
|
Others
|
|
2,3-Dibromosuccinic acid is the isomer of (±)-2,3-Dibromosuccinic acid (HY-133681), and can be used as an experimental control. (±)-2,3-Dibromosuccinic acid is the key intermediate in the synthesis of dicarboxylic acid derivatives .
|
-
- HY-13986A
-
|
(R)-VX-497; (R)-MMPD
|
Others
|
Infection
|
|
(R)-Merimepodib is the isomer of Merimepodib (HY-13986), and can be used as an experimental control. Merimepodib (VX-497) is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.
|
-
- HY-76082R
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Pyroglutamic acid (Standard) is the analytical standard of L-Pyroglutamic acid. This product is intended for research and analytical applications. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
|
-
- HY-N0557R
-
|
|
Others
|
Cancer
|
|
Isoescin IB (Standard) is the analytical standard of Isoescin IB. This product is intended for research and analytical applications. Isoescin IB is an isomer of Escin IB. Isoescin IB and Escin IB are the chief active ingredients in escin .
|
-
- HY-10017A
-
|
|
CXCR
|
Inflammation/Immunology
Endocrinology
|
|
(R)-SCH 546738 is the R-isomer of SCH 546738 (HY-10017). SCH 546738 is an orally active and non-competitive antagonist for CXCR3 with Ki of 0.4 nM for human CXCR3 receptor .
|
-
- HY-165542
-
|
|
Others
|
Others
|
|
9-cis-Astaxanthin, an isomer of astaxanthin (3,3-dihydroxy-β,β-carotene-4,4-dione), is part of the xanthophyll family, which consists of oxygenated derivatives of carotenoids.
|
-
- HY-B1583R
-
|
|
TRP Channel
HSV
|
Neurological Disease
|
|
(Z)-Capsaicin (Standard) is the analytical standard of (Z)-Capsaicin. This product is intended for research and analytical applications. (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.
|
-
- HY-66022
-
5-FAM
3 Publications Verification
5-Carboxyfluorescein
|
Fluorescent Dye
|
Others
|
|
5-FAM (5-Carboxyfluorescein) is a green fluorescent reagent used for in situ labeling peptides, proteins and nucleotides. 5-FAM is a single isomer with Ex/Em of 490 nm/520 nm .
|
-
- HY-W012708
-
|
|
Endogenous Metabolite
|
Others
|
|
3-Amino-4-methylpentanoic acid is a beta amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase.
|
-
- HY-N0445
-
|
|
Tyrosinase
Bacterial
|
Cancer
|
|
2-hydroxy-4-methoxybenzaldehyde is a potent tyrosinase inhibitor . 2-Hydroxy-4-methoxybenzaldehyde, an isomer of Vanillin, could be used to synthesis Urolithin M7
|
-
- HY-N0471A
-
|
Daturine sulfate
|
mAChR
|
Neurological Disease
|
|
L-Hyoscyamine sulfate (Daturine sulfate), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate is a levo-isomer to Atropine (HY-B1205) .
|
-
- HY-I1060S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
L-Alloisoleucine-d10 is the deuterium labeled L-Alloisoleucine. L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).
|
-
- HY-N0326S6
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Methionine- 13C5, 15N is the 13C- and 15N-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
- HY-N0326S9
-
-
- HY-Y0017S
-
-
- HY-N1394S1
-
|
4-Methoxybenzoic acid-d4; Draconic acid-d4
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
p-Anisic acid-d4 is the deuterium labeled p-Anisic acid[1]. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties[2].
|
-
- HY-W012550
-
|
|
Parasite
|
Infection
|
|
D-Carnitine is an orally available isomer of the essential nutrient L-carnitine that promotes long-chain fatty acid transport into the mitochondrial matrix for beta-oxidation. D-Carnitine has antiparasitic activity .
|
-
- HY-Y0003
-
|
|
Others
|
Others
|
|
(Rac)-BINAP is the isomer of (R)-BINAP (HY-W017757), and can be used as an experimental control. (R)-BINAP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-Y0982
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(S)-BINAP is the isomer of (R)-BINAP (HY-W017757), and can be used as an experimental control. (R)-BINAP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-N2715A
-
|
|
NO Synthase
|
Inflammation/Immunology
|
|
(2R)-6-Methoxynaringenin is the R isomer of 6-Methoxynaringenin (HY-N2715). 6-Methoxynaringenin is a flavonoid, that inhibits NO production with an IC50 of 25.8 μM .
|
-
- HY-163529A
-
|
|
HSV
|
Infection
|
|
(S)-HN0037 is the (S)-isomer of HN0037 (HY-163529), a selective and orally active helicase-primase inhibitor that inhibits HSV replication by targeting the viral helicase-primase enzyme complex .
|
-
- HY-120623
-
|
|
Na+/H+ Exchanger (NHE)
|
Neurological Disease
|
|
BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats. .
|
-
- HY-B0204B
-
|
(-)-UD-CG115
|
Others
|
Cardiovascular Disease
|
|
(-)-Pimobedan is an isomer of pimobedan. It has the property of stereoselective partitioning or distribution into erythrocytes. The clearance of (-)-pimobedan from erythrocytes is significantly lower than that of (+)-pimobedan, which is entirely due to its stereoselective distribution into erythrocytes. This stereoselective property of (-)-pimobedan may explain the phenomenon previously reported that it produces a 1.5-fold greater contractile force than the (+)-isomer in detergent-treated myocardial specimens of guinea pigs and dogs. These properties suggest that (-)-pimobedan may have unique advantages in terms of in vivo distribution and pharmacological action, which may have important implications for its clinical use.
|
-
- HY-100219
-
|
|
VD/VDR
|
Cancer
|
|
CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM .
|
-
- HY-158570
-
|
|
Bacterial
|
Infection
|
|
(2E)-Eicosenoic acid is an inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA). (2E)-Eicosenoic acid exhibits strong inhibitory activity against PtpA with an IC50 value in the low micromolar range. (2E)-Eicosenoic acid can be used for research on Mycobacterium tuberculosis infection .
|
-
- HY-15938
-
|
|
Fluorescent Dye
|
Others
|
|
5-FAM SE is a single isomer, is a fluorescent labeling reagent used for labeling peptides, proteins and nucleotides. 5-FAM SE can react with amines and can yield stable amine conjugates .
|
-
- HY-78139S
-
|
L-(-)-Xylose-1-13C
|
Isotope-Labeled Compounds
|
Others
|
|
L-Xylose-1- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
|
-
- HY-78139S1
-
|
L-(-)-Xylose-2-13C
|
Isotope-Labeled Compounds
|
Others
|
|
L-Xylose-2- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
|
-
- HY-78139S2
-
|
L-(-)-Xylose-5-13C
|
Isotope-Labeled Compounds
|
Others
|
|
L-Xylose-5- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
|
-
- HY-N0351S1
-
|
trans-4-Hydroxycinnamic acid-d6
|
Endogenous Metabolite
|
Cancer
|
|
p-Coumaric acid-d6 is the deuterium labeled p-Coumaric acid (HY-N0351). p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities[1][2].
|
-
- HY-116601
-
|
|
Others
|
Others
|
|
6-Hydroxywarfarin is a metabolite of (+) -warfarin. 6-Hydroxywarfarin is a weaker vitamin K antagonist. 6-Hydroxywarfarin is metabolized by the cytochrome P450 isomer 2C9 (CYP2C9) .
|
-
- HY-156063A
-
|
|
Parasite
|
Infection
|
|
(2R,4R)-UCB7362 hydrochloride is the (2R,4R) isomer of UCB7362, an inhibitor of plasma proteinase X (PMX) with antimalarial activity .
|
-
- HY-76082S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
L-Pyroglutamic acid-13C5 is a deuterated labeled L-Pyroglutamic acid . L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
|
-
- HY-Y0079R
-
|
|
Endogenous Metabolite
|
Others
|
|
D-Phenylalanine (Standard) is the analytical standard of D-Phenylalanine. This product is intended for research and analytical applications. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014 .
|
-
- HY-138563A
-
|
|
Others
|
Others
|
|
(2R,3R)-GSK973 is an isomer of GSK973. GSK973 is a highly selective, orally bioavailable inhibitor of the BD2s (second bromodomains) of the BET family .
|
-
- HY-N12883
-
|
|
Others
|
Endocrinology
|
|
(E,E)-11,13-Hexadecadien-1-ol is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) .
|
-
- HY-135383B
-
|
|
Others
|
Metabolic Disease
|
|
(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin calcium inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells .
|
-
- HY-75087
-
|
(+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-pyrrolidine-2-carboxylic acid ((+)-(R)-Proline) is a proline isomer that exhibits high renal and hepatotoxicity in rats. (R)-pyrrolidine-2-carboxylic acid can be used to study amino acid metabolism and toxicity mechanisms .
|
-
- HY-B1453S1
-
|
DL-Carnitine-d9 (chloride)
|
Reactive Oxygen Species
|
Metabolic Disease
|
|
(±)-Carnitine-d9 (chloride) is the deuterium labeled (±)-Carnitine chloride. (±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.
|
-
- HY-16950A
-
|
Afimoxifene
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Cancer
|
|
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is an estrogen receptor modulator.
|
-
- HY-N2059
-
|
|
Others
|
Cancer
|
|
Santalol is a mixture of α and β-isomer santalol. α-santalol is isolated from sandalwood oil. α-santalol is a promising anti-cancer agent against cancers such as oral, breast, prostate and skin cancer .
|
-
- HY-Y0444
-
|
|
Tyrosinase
|
Metabolic Disease
|
|
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .
|
-
- HY-W008914
-
|
|
EGFR
|
Cancer
|
|
(E/Z)-CP-724714 is a racemic compound of (E)-CP-724714 and (Z)-CP-724714 isomers. CP-724714 is a potent and selective orally active ErbB2 (HER2) inhibitor .
|
-
- HY-133016A
-
|
|
MetAP
|
Others
|
|
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor .
|
-
- HY-150691
-
|
|
SARS-CoV
|
Cancer
|
|
SARS 3CLpro-IN-1 (Compound 3b) is a SARS 3CL protease inhibitor with an IC50 value of 95 μM, as a specific stereo isomer
of the octahydroisochromene scaffold, directs the P1 site imidazole .
|
-
- HY-139573A
-
|
(Rac)-FT-4202
|
Pyruvate Kinase
|
Cardiovascular Disease
|
|
(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies .
|
-
- HY-147255A
-
|
(S)-ZM-H1505R
|
Others
|
Infection
|
|
(S)-Canocapavir is the isomer of Canocapavir (HY-147255A). Canocapavir (ZM-H1505R) has orally antiviral activity. Canocapavir is a HBV capsid inhibitor that can be used in the research of Chronic hepatitis B .
|
-
- HY-118590A
-
|
|
Topoisomerase
|
Cancer
|
|
ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193 (HY-118590). ICRF-193 is an TopoII inhibitor. ICRF-196 can be used for the research of cancer .
|
-
- HY-111789A
-
|
(S)-TAK-981
|
Others
|
Inflammation/Immunology
Cancer
|
|
(S)-Subasumstat is the isomer of Subasumstat (HY-111789), and can be used as an experimental control. Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities .
|
-
- HY-15676A
-
|
RG7388 (enantiomer)
|
Others
MDM-2/p53
|
Cancer
|
|
Idasanutlin enantiomer is the isomer of Idasanutlin (HY-15676), and can be used as an experimental control. Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM.
|
-
- HY-15251A
-
|
(Rac)-Repertaxin; (Rac)-DF 1681Y
|
Others
|
Inflammation/Immunology
Endocrinology
Cancer
|
|
(Rac)-Reparixin is the isomer of Reparixin (HY-15251), and can be used as an experimental control. Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM, respectively.
|
-
- HY-130226
-
-
- HY-W016814R
-
|
|
Endogenous Metabolite
|
Others
|
|
(Z)-Aconitic acid (Standard) is the analytical standard of (Z)-Aconitic acid. This product is intended for research and analytical applications. (Z)-Aconitic acid (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
|
-
- HY-122464B
-
|
2-iso Jasmonic acid; 7-iso Jasmonic acid
|
Others
|
Others
|
|
7-epi Jasmonic acid is the isomer of (±)-Jasmonic acid (HY-122464). (±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.
|
-
- HY-W010589S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
H-Abu-OH-d3 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
|
-
- HY-W010589S1
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
|
-
- HY-W010589S2
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
H-Abu-OH-d6 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
|
-
- HY-142016
-
|
9-cis,13-cis-Retinyl palmitate; 9-cis,13-cis-Vitamin A palmitate
|
Biochemical Assay Reagents
|
Others
|
|
Retinol, palmitate, 9-cis,13-cis- is the palmitate isomer of vitamin A. Retinol, palmitate, 9-cis,13-cis- can be test bioactivity through rat vaginal smear assays .
|
-
- HY-104028B
-
|
|
Others
Phosphodiesterase (PDE)
|
Neurological Disease
|
|
(S)-BAY 73-6691 is the isomer of BAY 73-6691 (HY-104028), and can be used as an experimental control. BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor .
|
-
- HY-B0191A
-
|
5,6-trans-AGN 192024
|
Others
|
Endocrinology
Cancer
|
|
5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.
|
-
- HY-15743A
-
|
(R)-OTX-015; (R)-MK-8628
|
Others
|
Cancer
|
|
(R)-Birabresib is the isomer of Birabresib (HY-15743), and can be used as an experimental control. Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM.
|
-
- HY-15958A
-
|
|
Others
|
Cancer
|
|
(S,R,R)-VBY-825 is the isomer of VBY-825 (HY-15958), and can be used as an experimental control. VBY-825 is a novel reversible inhibitor of cathepsin with high inhibition of cathepsin B, L, S and V.
|
-
- HY-122178
-
|
|
PGE synthase
|
Cardiovascular Disease
|
|
5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 (HY-121825). 5-trans U-44069 inhibits prostaglandin E2 synthase activity .
|
-
- HY-126308
-
|
|
Cytochrome P450
|
Cancer
|
|
(E/Z)-DMU2139 (Compound 180) is the E/Z isomer of DMU2139 (HY-101285). (E/Z)-DMU2139 is a potent and specific CYP1B1 inhibitor (IC50: 4 nM) .
|
-
- HY-Y0017R
-
|
|
Influenza Virus
Endogenous Metabolite
|
Infection
Cancer
|
|
L-Norleucine (Standard) is the analytical standard of L-Norleucine. This product is intended for research and analytical applications. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
|
-
- HY-W718351
-
|
C18:1(8Z); cis-8-Octadecenoate; Δ8-cis-Octadecenoic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
cis-8-Octadecenoic acid is a monounsaturated fatty acid and an isomer of oleic acid (HY-N1446), trans-vaccenic acid (HY-113427), trans-petroselinic acid, and cis-petroselinic acid. It has been found in partially hydrogenated vegetable oil and milk fat.
|
-
- HY-113972A
-
|
|
Others
|
Inflammation/Immunology
|
|
(E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides .
|
-
- HY-131833A
-
|
|
ADC Linker
|
Cancer
|
|
Fmoc-Gly-Gly-D-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OH is the D-isomer of Fmoc-Gly-Gly-Phe-OH (HY-131833).
|
-
- HY-W017277
-
|
D-Menthol
|
Others
|
Neurological Disease
|
|
(+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .
|
-
- HY-118590
-
|
|
Topoisomerase
|
Cancer
|
|
ICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer .
|
-
- HY-12940A
-
|
|
Free Fatty Acid Receptor
|
Metabolic Disease
|
|
(S)-GLPG0974 is the isomer of GLPG0974 (HY-12940), and can be used as an experimental control. GLPG0974 is a free fatty acid receptor-2 (FFA2/GPR43) antagonist with an IC50 of 9 nM.
|
-
- HY-137516A
-
|
|
PROTACs
Ras
|
Cancer
|
|
LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849 .
|
-
- HY-B0522C
-
|
L-(+)-α-Aminobenzylpenicillin
|
Others
|
Infection
|
|
L-(+)-Ampicillin (L-(2S) ampicillin) is the L-isomer of Ampicillin (HY-B0522). Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria .
|
-
- HY-167736
-
|
|
Others
|
Others
|
|
(2R)-Naroparcil is an isomer of Naroparcil, a 4-methylumbelliferyl beta-D-xyloside analog that plays a role in promoting vascular smooth muscle cell proliferation and has been shown to inhibit thrombus formation in the Wessler slough model.
|
-
- HY-15464
-
|
AT-101; R-(-)-gossypol acetic acid
|
Bcl-2 Family
Autophagy
|
Cancer
|
|
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
|
-
- HY-N0351
-
|
trans-4-Hydroxycinnamic acid
|
Endogenous Metabolite
Bacterial
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities .
|
-
- HY-44234A
-
|
|
ADC Linker
|
Cancer
|
|
Fmoc-Gly-Gly-D-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OtBu is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu (HY-44234) .
|
-
- HY-15005A
-
|
|
HCV
|
Infection
|
|
PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-102094
-
|
|
mGluR
|
Neurological Disease
|
|
(E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist .
|
-
- HY-W002299
-
|
Boc-D-Leu-OH hydrate
|
Amino Acid Derivatives
|
Neurological Disease
|
|
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine. D-Leucine is an unnatural isomer of L-Leucine that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect .
|
-
- HY-10508
-
|
|
MEK
|
Cancer
|
|
(R)-PD 0325901CL is an isomer of PD 0325901CL. PD 0325901CL is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) involved in cancer research. PD 0325901CL inhibits the growth of cancer cells in vitro and in vivo .
|
-
- HY-100741A
-
|
|
Others
|
Cancer
|
|
(S,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1 .
|
-
- HY-100741C
-
|
|
Others
|
Cancer
|
|
(R,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1 .
|
-
- HY-76542B
-
|
(R)-Ergocalciferol; (R)-Calciferol; (R)-Ercalciol
|
Drug isomer
|
Metabolic Disease
Cancer
|
(R)-Vitamin D2 is the isomer of Vitamin D2 (HY-76542), and can be used as an experimental control. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D .
|
-
- HY-161414
-
|
|
Others
|
Others
|
|
trans-VUF25471 (Compound trans-3e) is a photoswitchable ACKR3 agonist. trans-VUF25471 binds and activates ACKR3 at 10-fold lower concentrations compared to its cis-isomer .
|
-
- HY-101704A
-
|
H 409-22 isomer formic
|
Neurokinin Receptor
|
Neurological Disease
|
|
Y1 receptor antagonist 1 formic (H 409-22 isomer formic) is the formic salt form of Y1 receptor antagonist 1 (HY-101704). Y1 receptor antagonist 1 formic is a neuropeptide Y1 receptor antagonist.
|
-
- HY-130239A
-
|
(±)14-HDoHE; 14-hydroxy Docosahexaenoic acid; (±)14-HDoHE
|
Drug Metabolite
|
Neurological Disease
|
|
(±)14-HDHA is the isomer of 14(S)-HDHA (HY-130239). 14(S)-HDHA is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .
|
-
- HY-12788A
-
|
|
Phosphodiesterase (PDE)
|
Neurological Disease
|
|
(S)-PF-04449613 is the left-handed isomer of PF-04449613 (HY-12788). PF-04449613 is a selective PDE9A inhibitor with an IC50 of 22 nM. PF-04449613 improves motor learning ability in a mouse model .
|
-
- HY-153343A
-
|
|
DGK
ERK
|
Cancer
|
|
(S)-BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343). BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer .
|
-
- HY-113061
-
-
- HY-N0471S
-
|
Daturine-d3
|
mAChR
|
Neurological Disease
|
|
L-Hyoscyamine-d3 is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].
|
-
- HY-142050
-
|
|
Calcium Channel
|
Cardiovascular Disease
|
|
(R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca 2+ release and Ca 2+ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. IDHP is used in studies of cardiovascular disease .
|
-
- HY-B0003A
-
|
1'-epi LY 188011 hydrochloride
|
Apoptosis
|
Cancer
|
|
1'-epi Gemcitabine hydrochloride is the isomer of Gemcitabine hydrochloride (HY-B0003), and can be used as an experimental control. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .
|
-
- HY-113381A
-
|
(R)-α-Hydroxybutyric acid
|
Others
|
Metabolic Disease
|
|
(R)-2-Hydroxybutanoic acid is the isomer of 2-Hydroxybutyric acid (HY-113381), and can be used as an experimental control. 2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite .
|
-
- HY-A0148B
-
|
(-)-SKF-102886 free base; (-)-WR-171669
|
Parasite
|
Infection
|
|
(-)-Halofantrine ((-)-SKF-102886 free base; (-)-WR-171669) is an inhibitor of the malignant malaria parasite (P. falciparum) and targets multidrug-resistant P. falciparum. The pharmacokinetic parameters of (-)-Halofantrine in rats vary depending on the route of administration, distinguishing it from other isomers .
|
-
- HY-N0363R
-
|
|
Fungal
|
Infection
Inflammation/Immunology
|
|
(+)-Columbianetin (Standard) is the analytical standard of (+)-Columbianetin. This product is intended for research and analytical applications. (+)-Columbianetin is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity .
|
-
- HY-169234
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
BChE-IN-35 (Azo-9) is a BChE inhibitor. BChE-IN-35 has a dynamic cis/trans conformational change, where the cis isomer preferentially binds to BChE. BChE-IN-35 can be used in Alzheimer's disease (AD) research .
|
-
- HY-N7801
-
|
|
Others
|
Metabolic Disease
|
|
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
|
-
- HY-117044A
-
|
|
Others
|
Metabolic Disease
|
|
(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s=8.6-8.8 μM).
|
-
- HY-121535
-
|
|
Others
|
Others
|
|
Levosemotiadil, an S-isomer of semotiadil, exhibits stronger binding affinity to human serum albumin (HSA) compared to its R-isomer counterpart. This study utilized high-performance frontal analysis (HPFA) to demonstrate that levosemotiadil binds approximately three times more strongly to HSA than semotiadil. The binding parameters were evaluated using Scatchard analysis, revealing specific interactions with the diazepam binding site on HSA. The presence of diazepam decreased the binding affinity of both enantiomers, while warfarin did not alter their binding characteristics. These findings highlight levosemotiadil's potential as a Ca- and Na-channel blocker with significant binding preferences for HSA, crucial for understanding its pharmacokinetics and therapeutic effects .
|
-
- HY-12871A
-
|
(+)-BAY-1143572
|
CDK
|
Cancer
|
|
(+)-Atuveciclib is the isomer of Atuveciclib (Racemate) (HY-12871). Atuveciclib Racemate (BAY-1143572 Racemate) is the racemate mixture of Atuveciclib. Atuveciclib is a potent and highly selective，oral P-TEFb/CDK9 inhibitor which supresses CDK9/CycT1 with an IC50 of 13 nM.
|
-
- HY-15464A
-
|
AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid
|
Bcl-2 Family
Autophagy
|
Cancer
|
|
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
|
-
- HY-N0326
-
|
|
Endogenous Metabolite
Keap1-Nrf2
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
L-Methionine is an L-isomer of orally active Methionine, an essential amino acid. Methionine is a strong liver antidote that acts as a liver protector. L-Methionine can inhibit cell proliferation and induce cell apoptosis. L-Methionine has antitumor and antioxidant activity .
|
-
- HY-133068A
-
|
|
COMT
|
Metabolic Disease
|
|
(E)-5-Hydroxyferulic acid is the E-isomer of 5-hydroxyferulic acid (HY-133068). 5-hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrat .
|
-
- HY-118090
-
|
|
Others
|
Others
|
|
L-γ-Glutamyl-L-glutamic acid is the isomer of D-γ-Glutamyl-D-glutamic acid (HY-118090A), and can be used as an experimental control. D-γ-Glutamyl-D-glutamic acid is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain .
|
-
- HY-N12955
-
|
|
Endogenous Metabolite
|
Others
|
|
8(R),9(S)-EET is an isomer of Epoxyeicosatrienoic acid (HY-113489). 8(R),9(S)-EET processes its metabolism with cytosolic epoxide hydrolase (cEH), with a binding affinity of Km of 41 μM .
|
-
- HY-113381B
-
|
(R)-α-Hydroxybutyric acid sodium
|
Others
|
Others
|
|
(R)-2-Hydroxybutanoic acid ((R)-α-Hydroxybutyric acid) sodium is the R-isomer of 2-Hydroxybutyric acid (HY-113381), and can be used as an experimental control. 2-Hydroxybutyric acid is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite .
|
-
- HY-N0363AR
-
|
|
Fungal
|
Infection
Inflammation/Immunology
|
|
(+)-Columbianetin acetate (Standard) is the analytical standard of (+)-Columbianetin acetate. This product is intended for research and analytical applications. (S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity .
|
-
- HY-126028A
-
-
- HY-10572B
-
-
- HY-N1778A
-
|
(E)-O-Methylferulic acid
|
Reactive Oxygen Species
Virus Protease
|
Infection
Cancer
|
|
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .
|
-
- HY-N1867
-
|
|
PPAR
|
Metabolic Disease
|
|
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .
|
-
- HY-N0471R
-
|
|
mAChR
|
Neurological Disease
|
|
L-Hyoscyamine (Standard) is the analytical standard of L-Hyoscyamine. This product is intended for research and analytical applications. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) .
|
-
- HY-119961
-
|
Dexivacaine; (S)-Mepivacaine
|
Others
|
Cardiovascular Disease
|
|
(+)-Mepivacaine is a racemic isomer of Mepivacaine (HY-B0517), which has analgesic and vasoconstrictive activity. Mepivacaine is an amide type agent that temporarily causes local loss of consciousness. Mepivacaine binds to specific voltage-gated sodium channels on neuronal cell membranes, inhibiting sodium influx and membrane depolarization .
|
-
- HY-B1000A
-
|
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
|
L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase .
|
-
- HY-110155A
-
|
|
Others
|
Neurological Disease
|
|
(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75 NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist .
|
-
- HY-B1617AS
-
|
|
Estrogen Receptor/ERR
|
Metabolic Disease
Endocrinology
|
|
Zuclomiphene-d4 (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].
|
-
- HY-D1199
-
|
|
P2X Receptor
P2Y Receptor
|
Inflammation/Immunology
|
|
Blue FPG-A trisodium is a selective antagonist of P2X1 receptor and P2Y1 receptor with IC50 values of 35.5 μM and 2.6 μM, respectively. Blue FPG-A trisodium is a structural isomer of the components of Reactive Blue 2 (RB2) .
|
-
- HY-119316A
-
|
|
HDAC
Phosphodiesterase (PDE)
|
Neurological Disease
|
|
(cis)-CM-414, the cis-isomer of CM-414, is a dual inhibitor of PDE5, HDAC1, HDAC2, HDAC3, and HDAC6 with pIC50 values of 7.47, 6.65, 6.14, 6.55, and 6.84, repectively .
|
-
- HY-B0267C
-
|
Aroxybutynin
|
mAChR
|
Neurological Disease
|
|
(R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction .
|
-
- HY-106359
-
-
- HY-106359A
-
|
RDP-58 acetate
|
TNF Receptor
IFNAR
Reactive Oxygen Species
|
Cancer
|
|
Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis .
|
-
- HY-13245A
-
|
(s)-INCB8761
|
Others
|
Inflammation/Immunology
Endocrinology
|
|
(s)-PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
|
-
- HY-136350B
-
|
|
Others
|
Cancer
|
|
(S)-BRD9500 is the isomer of BRD9500 (HY-136350), and can be used as an experimental control. BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC50s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity .
|
-
- HY-18629A
-
|
|
Apoptosis
CDK
Autophagy
|
Cancer
|
|
(E/Z)-SU9516 is the isomer of SU9516 (HY-18629). SU9516 is a potent CDK2 inhibitor，with an IC50 of 22 nM，and also shows inhibitory effects on CDK1 and CDK4，with IC50s of 40，200 nM，respectively.
|
-
- HY-163646
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
(Rac)-TZ3O is the (Rac) isomer of TZ3O. TZ3O is an anticholinergic compound with neuroprotective activity. TZ3O improves memory impairment and cognitive decline in a scopolamine-induced Alzheimer's disease rat model and can be used in the study of Alzheimer's disease.
|
-
- HY-N5056R
-
|
|
Influenza Virus
|
Others
|
|
DL-Goitrin (Standard) is the analytical standard of DL-Goitrin. This product is intended for research and analytical applications. DL-Goitrin, also called (R, S)-report by the spring, consists of the epigoitrin (reported by the R-Spring) and the spring (-S-reported by spring), and the two mutually isomers, and the mixture is the ingredient of cruciferous vegetables .
|
-
- HY-165111
-
|
1,2-Olein-3-myristin; TG(18:1/18:1/14:0)
|
Others
|
Others
|
|
1,2-Dioleoyl-3-myristoyl-rac-glycerol (1,2-Olein-3-myristin) is a compound that is being studied as a triglyceride in bumblebee fat body. Chromatographic analysis revealed differences in fatty acid composition and triglyceride isomer distribution in different bumblebee species.
|
-
- HY-128888
-
|
|
Isocitrate Dehydrogenase (IDH)
|
Cancer
|
|
(R,R)-GSK321 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. (R,R)-GSK321 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity .
|
-
- HY-139612A
-
|
(S)-NVP-JDQ443
|
Ras
PERK
|
Cancer
|
|
(S)-JDQ-443 is an isomer of JDQ-443 (HY-139612). JDQ-443 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). JDQ-443 shows antitumor activity .
|
-
- HY-112433A
-
|
|
NF-κB
|
Inflammation/Immunology
|
|
(S)-NIK SMI1 is the isomer of NIK SMI1 (HY-112433), and can be used as an experimental control. NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17 nM.
|
-
- HY-W016814S
-
|
cis-Aconitic acid-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
(Z)-Aconitic acid- 13C6 is the 13C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
|
-
- HY-16950BS
-
|
(E)-Afimoxifene-d5
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
|
Cancer
|
|
(E)-4-Hydroxytamoxifen-d5 ((E)-Afimoxifene-d5) is the deuterium labeled (E)-4-Hydroxytamoxifen. (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator.
|
-
- HY-162827
-
|
|
RAR/RXR
Apoptosis
|
Cancer
|
|
RAR/RXR agonist-1 (compound 7) is a chlorinated retinoic acid isomer, a selective RARα agonist and a partial RXRα agonist. RAR/RXR agonist-1 can activate RXRα and induce G2/M arrest and apoptosis in cancer cells .
|
-
- HY-126108
-
|
|
Others
|
Metabolic Disease
|
|
(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of (±)8-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.
|
-
- HY-N8356
-
|
13-cis-Retinyl palmitate
|
Endogenous Metabolite
|
Others
|
|
13-cis-Vitamin A palmitate (13-cis-Retinyl palmitate) is a 13-cis isomer formed by vitamin A palmitate in corn flakes. 13-cis-Vitamin A palmitate has a biological activity of 75% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .
|
-
- HY-N8356A
-
|
9-cis-Retinyl palmitate
|
Endogenous Metabolite
|
Others
|
|
9-cis-Vitamin A palmitate (9-cis-Retinyl palmitate) is a 9-cis isomer formed by vitamin A palmitate in corn flakes. 9-cis-Vitamin A palmitate has a biological activity of 26% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .
|
-
- HY-Y0444S
-
|
|
Isotope-Labeled Compounds
Tyrosinase
|
Metabolic Disease
|
|
D-Tyrosine-d2 is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].
|
-
- HY-Y0444S1
-
|
|
Tyrosinase
|
Metabolic Disease
|
|
D-Tyrosine-d4 is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].
|
-
- HY-Y0444S2
-
|
|
Isotope-Labeled Compounds
Tyrosinase
|
Metabolic Disease
|
|
D-Tyrosine-d7 is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].
|
-
- HY-122938
-
|
(2S,3R)-Ceplignan
|
Others
|
Others
|
|
Ceplignan ((2S,3R)-Ceplignan) is a neogenic lignan, which can be isolated from the rhizomes of Acorus tatarinowii Schott. (2S,3R)-Ceplignan and (2R,3S)-ceplignan are two isomers of Ceplignan .
|
-
- HY-B0584A
-
|
5,6-trans-Fluprostenol isopropyl ester; 5,6-trans-AL6221; 5,6-trans-Flu-Ipr
|
Others
Drug isomer
|
Endocrinology
|
|
5,6-trans-Travoprost is the isomer of Travoprost (HY-B0584), and can be used as an experimental control. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .
|
-
- HY-111271B
-
|
|
Others
|
Inflammation/Immunology
Endocrinology
|
|
(R)-L 888607 is the isomer of L 888607 (HY-111271), and can be used as an experimental control. L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite .
|
-
- HY-113061S
-
-
- HY-148718R
-
|
|
Others
|
Neurological Disease
|
|
4-Chloro Trazodone (hydrochloride) (Standard) is the analytical standard of 4-Chloro Trazodone (hydrochloride). This product is intended for research and analytical applications. 4-Chloro Trazodone hydrochloride is an isomer of Trazodone hydrochloride (HY-B0478). Trazodone hydrochloride is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders .
|
-
- HY-165112
-
|
1,2-Olein-3-α-linolenin; 1,2-Olein-3-linolenin; TG(18:1/18:1/18:3)
|
Others
|
Others
|
|
1,2-Dioleoyl-3-α-linolenoyl-rac-glycerol (1,2-Olein-3-α-linolenin) is a compound that is being studied as a triglyceride in bumblebee fat body. Chromatographic analysis revealed differences in fatty acid composition and triglyceride isomer distribution in different bumblebee species.
|
-
- HY-138794A
-
|
|
Deubiquitinase
|
Cancer
|
|
(Rac)-XL177A is the racemic isomer of XL177A (HY-138794). XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. XL177A elicits cancer cell-killing effects through a p53-dependent mechanism .
|
-
- HY-N0351A
-
|
cis-4-Hydroxycinnamic acid
|
Apoptosis
|
Metabolic Disease
|
|
cis-p-Coumaric acid (cis-4-Hydroxycinnamic acid) is the cis-form of p-Coumaric acid (HY-N0351), which is higher in viable seeds of groundnuts than in non-viable ones. p-Coumaric acid is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes Apoptosis .
|
-
- HY-P2996A
-
|
|
Others
|
Others
|
|
Nitrate Reductase, Arabidopsis thaliana is the isomer of NAD(P)H-Nitrate reductase (HY-P2996). NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants，the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .
|
-
- HY-107459
-
|
(E/Z)-Tyrphostin AG490; (E/Z)-Tyrphostin B42
|
EGFR
STAT
JAK
|
Cancer
|
|
(E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
|
-
- HY-110264
-
|
|
HDAC
Apoptosis
|
Neurological Disease
Cancer
|
|
MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities .
|
-
- HY-139553A
-
|
(R)-ATI-450; (R)-CDD-450
|
Others
|
Inflammation/Immunology
|
|
(R)-Zunsemetinib is the isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases .
|
-
- HY-123669A
-
|
|
P2Y Receptor
|
Cardiovascular Disease
|
|
Trans-R-138727 is the trans isomer of R-138727 (HY-123669). R-138727 is the active metabolite of the antiplatelet agent Prasugrel (HY-15284). R-138727 is an irreversible inhibitor for the platelet receptor P2Y12, and inhibits ADP-induced platelet activation and aggregation .
|
-
- HY-N0471AR
-
|
|
mAChR
|
Neurological Disease
|
|
L-Hyoscyamine (sulfate) (Standard) is the analytical standard of L-Hyoscyamine (sulfate). This product is intended for research and analytical applications. L-Hyoscyamine sulfate (Daturine sulfate), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate is a levo-isomer to Atropine (HY-B1205) .
|
-
- HY-W017277R
-
|
|
Others
|
Neurological Disease
|
|
(+)-Menthol (Standard) is the analytical standard of (+)-Menthol. This product is intended for research and analytical applications. (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .
|
-
- HY-75095
-
|
S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
(S)-(-)-1-Phenylethanamine (S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine) is a S-isomer of 1-Phenylethanamine (HY-W012848). 1-Phenylethanamine is a potential central nervous system stimulant and can be used to synthesize the tyrosine kinase inhibitor CLM3 (HY-164413) .
|
-
- HY-145595A
-
|
|
Ferroptosis
|
Others
|
|
(1R,3R)-Ferroptosis inducer-1 is an isomer of Ferroptosis inducer-1 (HY-145595). (1R,3R)-Ferroptosis inducer-1 (compound BX-3a) is a Ferroptosis inducer with antitumor potential .
|
-
- HY-129953B
-
|
15-epi PGF2α; 15(R)-PGF2α
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
15(R)-Prostaglandin F2α is the isomer of 9α,11β-Prostaglandin F2α (HY-129953). 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma .
|
-
- HY-112316A
-
|
|
Epigenetic Reader Domain
|
Cancer
|
|
(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome .
|
-
- HY-112762A
-
|
|
Arenavirus
|
Infection
|
|
(E)-LHF-535 is the E-isomer of LHF-535. LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively .
|
-
- HY-W018555
-
|
|
Endogenous Metabolite
Bacterial
|
Infection
Neurological Disease
|
|
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of Escherichia coli growth. D-cysteine is mediated by D-amino acid oxidase to produce H2S and is a neuroprotectant against cerebellar ataxias. D-Cysteine could inhibit the growth and cariogenic virulence of dual-species biofilms formed by S. mutans and S. sanguinis .
|
-
- HY-65039A
-
|
|
Others
|
Cancer
|
|
rel-Boc-Hyp-OMe is the isomer of Boc-Hyp-OMe (HY-65039), and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-14291B
-
|
(2R)-LAF237; (2R)-NVP-LAF 237
|
Others
|
Metabolic Disease
|
|
(2R)-Vildagliptin is the isomer of Vildagliptin (HY-14291), and can be used as an experimental control. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .
|
-
- HY-78931C
-
|
|
Others
|
Cancer
|
|
(S,S,R,S,R)-Boc-Dap-NE is an isomer of the dipeptide Boc-Dap-NE (HY-78931). Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
|
-
- HY-78931E
-
|
|
Others
|
Cancer
|
|
(R,S,R,S,R)-Boc-Dap-NE is an isomer of the dipeptide Boc-Dap-NE (HY-78931). Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
|
-
- HY-78931F
-
|
|
Others
|
Cancer
|
|
(R,S,S,S,R)-Boc-Dap-NE is an isomer of the dipeptide Boc-Dap-NE (HY-78931). Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
|
-
- HY-163452
-
|
|
Others
|
Metabolic Disease
|
|
Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC50 values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride .
|
-
- HY-113061R
-
|
|
Endogenous Metabolite
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
|
Others
|
|
Pseudouridine (Standard) is the analytical standard of Pseudouridine. This product is intended for research and analytical applications. Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation [4].
|
-
- HY-W422400
-
|
|
Biochemical Assay Reagents
|
Others
Cancer
|
|
Fluoroglutamine (2S,4R) is a fluorinated derivative of glutamine. As a substrate for various aminotransferases, Fluoroglutamine (2S,4R) can be used as a tracer for positron emission tomography (PET) imaging. Fluoroglutamine (2S,4R) is applied in the research fields of tumor metabolism and imaging .
|
-
- HY-113071C
-
|
(S)-MVA
|
Endogenous Metabolite
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
|
|
(S)-Mevalonic acid is the isomer of Mevalonic acid (HY-113071). Mevalonic acid ((S)-DCIT) is a precursor substance of the mevalonate pathway，which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .
|
-
- HY-113739A
-
|
(S)-DCIT
|
Cytochrome P450
|
Neurological Disease
|
|
(S)-Desmethylcitalopram is the isomer of Desmethylcitalopram hydrochloride (HY-113739). Desmethylcitalopram (DCIT) hydrochloride is the active metabolite of Citalopram (HY-121203). Desmethylcitalopram has antidepressant effects. Desmethylcitalopram also inhibits cytochrome P450-2D6，-2C19 with IC50s of 39.5 and 53.5 μM .
|
-
- HY-132451S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit is the deuterium labeled (R,S)-4-Hydroxy Cyclophosphamide Preparation Kit. (R,S)-4-Hydroxy Cyclophosphamide is an isomer of 4-Hydroxycyclophosphamide, the active metabolite of the cytotoxic alkylating agent Cyclophosphamide (HY-17420) .
|
-
- HY-N5097
-
|
|
PPAR
|
Metabolic Disease
|
|
13-Oxo-9E,11E-octadecadienoic acid, an isomer of 9-oxo-ODA, is a potent PPARα activator derived from tomato juice. 13-Oxo-9E,11E-octadecadienoic acid decreases plasma and hepatic triglyceride in obese diabetic mice .
|
-
- HY-114395A
-
|
|
Others
|
Inflammation/Immunology
|
|
(R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel agentgable node in the Notch pathway.
|
-
- HY-105084
-
|
|
Others
|
Neurological Disease
|
|
Lubeluzole is a neuroprotective anti-ischemic compound. Lubeluzole, but not its (-)-R-isomer, protects against sensorimotor deficits provoked by photochemical stroke in rats. Lubeluzole inhibited glutamate-stimulated guanosine 3',5'-cyclic monophosphate production with an IC50 of 37 nM. Lubeluzole also has the potential for developing a novel class of antibacterial adjuvants endowed with spasmolytic activity .
|
-
- HY-112149A
-
|
|
Epigenetic Reader Domain
|
Inflammation/Immunology
Cancer
|
|
(E/Z)-ZL0420 is a racemic compound of (Z)-ZL0420 and (E)-ZL0420 isomers. (E)-ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2 .
|
-
- HY-145670
-
|
|
Akt
MDM-2/p53
|
Cancer
|
|
cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase .
|
-
- HY-123109A
-
|
(S,S,S)-VH032-Boc
|
Others
|
Cancer
|
|
(S,S,S)-AHPC-Boc is the isomer of (S,R,S)-AHPC-Boc (HY-123109), and can be used as an experimental control. (S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology .
|
-
- HY-13631I
-
|
(1S,9R)-DX8951f
|
ADC Cytotoxin
Topoisomerase
|
Cancer
|
|
(1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) is an isomer of Exatecan mesylate (HY-13631A). Exatecan mesylate (DX8951f) is an inhibitor of DNA topoisomerase I with an IC50 of 2.2 μM (0.975 μg/mL) and can be used in cancer research .
|
-
- HY-137440B
-
|
(2R,3R)-TAK-994 free base
|
Orexin Receptor (OX Receptor)
|
Neurological Disease
|
|
(2R,3R)-Firazorexton ((2R,3R)-TAK-994 free base) is an isomer of Firazorexton (HY-137440). Firazorexton is an orally active, brain-penetrating orexin type 2 receptor (OX2R) agonist that may improve narcolepsy-like symptoms ..
|
-
- HY-135023
-
|
5-trans Prostaglandin E2
|
Cytochrome P450
Prostaglandin Receptor
|
Cancer
|
|
5-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase). This process is involved in the growth and development of breast cancer .
|
-
- HY-N0351R
-
|
|
Endogenous Metabolite
Bacterial
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
p-Coumaric acid (Standard) is the analytical standard of p-Coumaric acid. This product is intended for research and analytical applications. p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities .
|
-
- HY-N7092A
-
|
L-arabino-2-Hexulose, 95%
|
Endogenous Metabolite
|
Others
|
|
L-(+)-Fructose, 95% (L-arabino-2-Hexulose, 95%) is the L-isomer of D-Fructose (HY-N7092). L-(+)-Fructose, 95% is involved in glycolysis and gluconeogenesis, and can be used to study photosynthesis and carbohydrate storage in plant biology. L-(+)-Fructose, 95% can be used to investigate the activity of fructokinase and other fructose-metabolizing enzymes .
|
-
- HY-165116
-
|
18:0p/22:6-PE; C18(Plasm)-22:6-PE; PE(P-18:0/22:6)
|
Others
|
Others
|
|
1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p/22:6-PE) is a lipid identified in rat brain tissue by mass spectrometry imaging with specific structural and distribution characteristics, and isomers of different fatty acid chains can be identified by improved methods.
|
-
- HY-161611
-
|
|
Others
|
Others
|
|
Plant 14-3-3-IN-1 (Compound 2) is an inhibitor for 14-3-3 proteins in Arabidopsis thaliana, with an IC50 of 1.21 μM. Plant 14-3-3-IN-1 exhibits different inhibitory activities against different 14-3-3 isomers. Plant 14-3-3-IN-1 promotes the closure of stomata on leaves .
|
-
- HY-129555
-
|
|
Bacterial
HSV
Antibiotic
|
Infection
|
|
Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects . Surfactin also has antiviral activity against a variety of enveloped viruses .
|
-
- HY-134978B
-
|
|
SHMT
|
Cancer
|
|
(-)SHIN2 is the isomer of (+)SHIN2 (HY-134978A). (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate (HY-14519) in vivo xenotransplantation models . (-)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-77111
-
|
|
Others
|
Inflammation/Immunology
Endocrinology
|
|
cis-INCB3344 is the isomer of INCB3344 (HY-50674), and can be used as an experimental control. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
|
-
- HY-78931A
-
|
|
Others
|
Cancer
|
|
(R,S,S,R,S)-Boc-Dap-NE is the inactive isomer of Boc-Dap-NE (HY-78931), and can be used as an experimental control. Boc-Dap-NE, is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
|
-
- HY-146223A
-
|
|
Others
|
Cancer
|
|
(3R,10R,14aS)-AZD4625 is the isomer of AZD4625 (HY-146223), and can be used as an experimental control. AZD4625 (Compound 21) is a highly potent, selective, covalent and allosteric inhibitor of the mutant GTPase KRAS G12C. AZD4625 has high oral bioavailability .
|
-
- HY-13631J
-
|
(1R,9R)-DX8951f
|
ADC Cytotoxin
Topoisomerase
|
Cancer
|
|
(1R,9R)-Exatecan mesylate((1R,9R)-DX8951f) is an isomer of Exatecan mesylate (HY-13631A). Exatecan mesylate (DX8951f) is an inhibitor of DNA topoisomerase I with an IC50 of 2.2 μM (0.975 μg/mL) and can be used in cancer research .
|
-
- HY-78931B
-
|
|
Others
|
Cancer
|
|
(S,S,S,S,R)-Boc-Dap-NE is the inactive isomer of Boc-Dap-NE (HY-78931), and can be used as an experimental control. Boc-Dap-NE, is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
|
-
- HY-N3841A
-
|
|
Cytochrome P450
|
Metabolic Disease
|
|
δ-Viniferin is a resveratrol dehydrodimer, an isomer of ε-Viniferin (HY-N3841) . ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity.
|
-
- HY-N0326R
-
|
|
Endogenous Metabolite
Keap1-Nrf2
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
L-Methionine (Standard) is the analytical standard of L-Methionine. This product is intended for research and analytical applications. L-Methionine is an L-isomer of orally active Methionine, an essential amino acid. Methionine is a strong liver antidote that acts as a liver protector. L-Methionine can inhibit cell proliferation and induce cell apoptosis. L-Methionine has antitumor and antioxidant activity .
|
-
- HY-10396A
-
|
(2R,3S)-PF 03491390; (2R,3S)-IDN-6556
|
Caspase
Flavivirus
|
Infection
Neurological Disease
Cancer
|
|
(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan (HY-10396). Emricasan is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors .
|
-
- HY-10572BR
-
|
|
Autophagy
Parasite
HIV
Endogenous Metabolite
Reverse Transcriptase
|
Infection
Cancer
|
|
(Rac)-Efavirenz (Standard) is the analytical standard of (Rac)-Efavirenz. This product is intended for research and analytical applications. (Rac)-Efavirenz is the isomer of Efavirenz (HY-10572). Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .
|
-
- HY-116567A
-
|
|
Others
|
Endocrinology
|
|
(S)-OPC-51803 is an agonist of the vasopressin V2 receptor, with activity in suppressing nocturia and urinary incontinence. (S)-OPC-51803 was evaluated in terms of biological activity and showed a stronger V2 receptor agonist effect compared to its (R)-isomer. The use of (S)-OPC-51803 may improve the patient's ability to control nocturnal polyuria .
|
-
- HY-120982
-
|
|
Prostaglandin Receptor
|
Endocrinology
|
|
Cloprostenol is a synthetic prostaglandin F2α (PGF2α) analog and a potent FP receptor agonist. (+)-15-epi Cloprostenol is the 15(S), or 15β-hydroxy enantiomer of (+)-cloprostenol. This epimer is less active by several orders of magnitude as an FP receptor ligand when compared to 15(R)-cloprostenol. However, the specific activity of this isomer has not been well studied.
|
-
- HY-N6937
-
|
(R,R)-SDG; (R,R)-LGM2605
|
Others
|
Inflammation/Immunology
|
|
(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
|
-
- HY-100211A
-
|
(R)-TNF Protease Inhibitor 2
|
SARS-CoV
MMP
Others
|
Cancer
|
|
(R)-TAPI-2 is the isomer of TAPI-2 (HY-100211A). TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .
|
-
- HY-152107A
-
|
|
LRRK2
|
Neurological Disease
|
|
(R,R)-LRRK2-IN-7 is the isomer of LRRK2-IN-7 (HY-152107). LRRK2-IN-7 is a potent, selective, and CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. LRRK2-IN-7 shows >1000-fold selectivity over other kinases, ion channels, and CYP enzymes.
|
-
- HY-A0015A
-
|
|
Others
Histamine Receptor
|
Inflammation/Immunology
Endocrinology
|
|
(Rac)-Bepotastine (besilate) is the isomer of Bepotastine (besilate) (HY-A0015), and can be used as an experimental control. Bepotastine besilate is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine besilate has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research .
|
-
- HY-W112166
-
|
|
Others
|
Infection
|
|
(E/Z)-4,4'-Dicyanostilbene is the isomer of 4,4'-Dicyanostilbene (HY-W112166A), and can be used as an experimental control. 4,4'-Dicyanostilbene (compound 43) is a potent antimalarial agent against the Dd2 strain, with an EC50 of 27 nM. 4,4'-Dicyanostilbene exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA) .
|
-
- HY-12296A
-
|
(3S,5S,6R)-AMG 232; (3S,5S,6R)-KRT-232
|
Others
|
Cancer
|
|
(3S,5S,6R)-Navtemadlin is the isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM .
|
-
- HY-133807B
-
|
|
Others
|
Inflammation/Immunology
|
|
(R)-Benpyrine is the isomer of Benpyrine (HY-133807), and can be used as an experimental control. Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research .
|
-
- HY-135146A
-
|
|
Others
|
Cancer
|
|
(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity .
|
-
- HY-42487A
-
|
|
ADC Cytotoxin
Topoisomerase
|
Cancer
|
|
(rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer .
|
-
- HY-42487B
-
|
|
ADC Cytotoxin
Topoisomerase
|
Cancer
|
|
(R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer .
|
-
- HY-145386
-
|
|
Others
|
Cancer
|
|
(S,S)-CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity .
|
-
- HY-136285A
-
|
|
Others
|
Cancer
|
|
(R,R)-CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity .
|
-
- HY-103710A
-
|
|
RAD51
|
Cancer
|
|
(R)-IBR2 is the isomer of IBR2 (HY-103710). IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis .
|
-
- HY-16950AR
-
|
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Cancer
|
|
(E/Z)-4-Hydroxytamoxifen (Standard) is the analytical standard of (E/Z)-4-Hydroxytamoxifen. This product is intended for research and analytical applications. (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is an estrogen receptor modulator.
|
-
- HY-B1000AR
-
|
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
|
L-SelenoMethionine (Standard) is the analytical standard of L-SelenoMethionine. This product is intended for research and analytical applications. L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase .
|
-
- HY-165052
-
|
1,3-Didocosahexaenoin-2-palmitin; DPD; TG(22:6/16:0/22:6)
|
Others
|
Others
|
|
1,3-Didocosahexaenoyl-2-palmitoyl glycerol (1,3-Didocosahexaenoin-2-palmitin) is a compound that is being studied as a triglyceride positional isomer in fish and marine mammals. The fatty acid binding position of 1,3-Didocosahexaenoyl-2-palmitoyl glycerol varies in different organisms, which may be related to the substrate preference of related enzymes.
|
-
- HY-105135
-
|
|
Others
|
Cardiovascular Disease
|
|
15-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester is the (R,R,R)-isomer of Viprostol (HY-105135A) and a PGE2 analogue with antihypertensive property. 15-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester can be utilized in cardiovascular disease research .
|
-
- HY-13289B
-
|
(R)-SYN117 hydrochloride; (R)-RS-25560-197 hydrochloride; RS-25560-198 hydrochloride
|
Dopamine β-hydroxylase
|
Cardiovascular Disease
|
|
(R)-Nepicastat hydrochloride is the isomer of Nepicastat (HY-13289). Nepicastat (SYN117) is a selective，potent，and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB) .
|
-
- HY-15648A
-
GSK-J2
2 Publications Verification
|
Others
|
Cancer
|
|
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.
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-
- HY-14664B
-
|
(3R,5S)-XU 62-320 free acid
|
HMG-CoA Reductase (HMGCR)
Autophagy
|
Cardiovascular Disease
Cancer
|
|
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .
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-
- HY-112163A
-
|
rel-eFT226
|
Eukaryotic Initiation Factor (eIF)
SARS-CoV
Apoptosis
|
Infection
Cancer
|
|
rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex .
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-
- HY-125378A
-
|
(7R)-SBI-0636457; (7R)-SB1-0636457
|
Others
|
Cancer
|
|
(7R)-SBP-0636457 is the isomer of SBP-0636457 (HY-125378), and can be used as an experimental control. SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers .
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-
- HY-139664B
-
|
|
Others
|
Cancer
|
|
(S)-GSK-3685032 is the isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition .
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-
- HY-120039
-
|
|
Elastase
|
Inflammation/Immunology
|
|
(R)-MDL-101146 is the R-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis .
|
-
- HY-120039A
-
|
|
Elastase
|
Inflammation/Immunology
|
|
(S)-MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis .
|
-
- HY-112847B
-
|
(E/Z)-Sulfo-N-succinimidyl oleate sodium
|
Mitophagy
|
Inflammation/Immunology
|
|
(E/Z)-Sulfosuccinimidyl oleate sodium is a racemic compound of (Z)-Sulfosuccinimidyl oleate sodium and (Z)-Sulfosuccinimidyl oleate sodium isomers. Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Sulfosuccinimidyl oleate sodium has anti-inflammatory effect .
|
-
- HY-B0779A
-
|
(5E,9E,13E)-Geranylgeranylacetone
|
HSP
|
Metabolic Disease
|
|
(5E,9E,13E)-Teprenone ((5E,9E,13E)-Geranylgeranylacetone) is an isomer of Teprenone with antiulcer activity. (5E,9E,13E)-Teprenone induces transcriptional activation of HSP genes that may increase gastric mucosal defense at conditions of stress .
|
-
- HY-125021
-
2BAct
1 Publications Verification
|
Eukaryotic Initiation Factor (eIF)
|
Neurological Disease
|
|
2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495) .
|
-
- HY-134819A
-
|
(-)-trans-ML-SI3
|
TRP Channel
|
Neurological Disease
|
|
(1R,2R)-ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of three isoforms of TRPML. (1R,2R)-ML-SI3 inhibits TRPMLs with IC50s of 1.6 μM (TRPML1), 2.3 μM (TRPML2), and 12.5 μM (TRPML3), respectively .
|
-
- HY-134082A
-
|
|
Phospholipase
|
Inflammation/Immunology
|
|
(Z)-Oleyloxyethyl phosphorylcholine ((Z)-OPC) is an isomer of Oleyloxyethyl phosphorylcholine (OPC). Oleyloxyethyl phosphorylcholine is an inhibitor of secreted Phospholipase A2 (sPLA2), which is involved in the biosynthesis of proinflammatory lipid media. Oleyloxyethyl phosphorylcholine can be used to study inflammatory diseases. Oleyloxyethyl phosphorylcholine also modified the red blood membrane and was used to bind the oxygen-carrying liquid perfluorocarbons as an antivenom agent to reduce toxin-induced hemolysis .
|
-
- HY-100672B
-
|
|
Others
|
Cardiovascular Disease
Metabolic Disease
|
|
(2R)-SR59230A is the isomer of SR59230A (HY-100672), and can be used as an experimental control. SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively .
|
-
- HY-W007978B
-
|
2,2'-Diamino-1,1'-dinaphthyl
|
Others
|
Others
|
|
1,1'-Binaphthyl-2,2'-diamine is the isomer of (S)-[1,1'-Binaphthalene]-2,2'-diamine (HY-W007978A), and can be used as an experimental control. (S)-[1,1'-Binaphthalene]-2,2'-diamine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-70059A
-
|
|
Others
|
Neurological Disease
|
|
(Rac)-LY341495 is the isomer of LY341495 (HY-70059), and can be used as an experimental control. LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively .
|
-
- HY-14176A
-
|
|
Others
|
Cancer
|
|
(1R,3S)-Compound E is the isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
|
-
- HY-Z7721
-
|
(Rac)-TRK-100; (Rac)-ML 1129 sodium
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
(Rac)-Beraprost ((Rac)-ML 1229) sodium is a racemic isomer of Beraprost sodium (HY-13569A). Beraprost sodium is an orally active prostacyclin analog that inhibits the release of Ca 2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost sodium has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis .
|
-
- HY-139121
-
|
15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid; 15(R)-17-phenyl trinor PGF2α
|
Prostaglandin Receptor
|
Endocrinology
|
|
17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive agent. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hr. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or “unnatural” isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
|
-
- HY-130245A
-
|
|
PCSK9
|
Metabolic Disease
|
|
(R,R)-PCSK9 degrader 1 is the isomer of PCSK9 degrader 1 (HY-130245). PCSK9 degrader 1 (Compound 16) is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9 with a Ki of 107 nM. PCSK9 degrader 1 can involve in a protein-protein interaction with the low-density lipoprotein (LDL) receptor .
|
-
- HY-137453B
-
|
(1R)-HS-10234
|
HBV
HIV
|
Infection
|
|
(1R)-Tenofovir amibufenamide ((1R)-HS-10234) is the isomer of Tenofovir amibufenamide, is an orally active antiviral agent. (1R)-Tenofovir amibufenamide ((1R)-HS-10234) is a HIV infection inhibitor and HBV infection inhibitor. (1R)-Tenofovir amibufenamide ((1R)-HS-10234) can be used for HIV infections, hepatitis B research .
|
-
- HY-B0267B
-
|
Aroxybutynin hydrochloride
|
mAChR
|
Neurological Disease
|
|
(R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction . (R)-Oxybutynin (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-117583
-
|
|
HDAC
Histone Methyltransferase
|
Neurological Disease
|
|
cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research .
|
-
- HY-W007978
-
|
R-(-)-2,2-Diamino-1,1-binaphthyl
|
Others
|
Others
|
|
(R)-[1,1'-Binaphthalene]-2,2'-diamine is the isomer of (S)-[1,1'-Binaphthalene]-2,2'-diamine (HY-W007978A), and can be used as an experimental control. (S)-[1,1'-Binaphthalene]-2,2'-diamine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
![(R)-[1,1'-Binaphthalene]-2,2'-diamine](//file.medchemexpress.eu/product_pic/hy-w007978.gif)
- HY-125263B
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
(R)-OP-1074 is an isomer of OP-1074 (HY-125263) and can serve as a control compound in experiments. OP-1074, a pure anti-estrogen drug, is a selective ER degrader (PA-SERD) with specific anti-estrogenic activity against ERα and ERβ, inhibiting 17β-estradiol (E2)-stimulated transcription with IC50 values of 1.6 and 3.2 nM, respectively.
|
-
- HY-13991A
-
|
|
Ras
|
Metabolic Disease
Cancer
|
|
(S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes .
|
-
- HY-17626B
-
|
WCK-2349 hydrochloride
|
Antibiotic
|
Infection
|
|
Alalevonadifloxacin (hydrochloride) (WCK-2349 (hydrochloride)) is a oraaly active anti-methicillin-resistant Staphylococcus aureus (MRSA) antibiotic .
|
-
- HY-134123
-
|
LXB4 methyl ester
|
Others
|
Metabolic Disease
|
|
Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
|
-
- HY-138148
-
|
|
Others
|
Inflammation/Immunology
|
|
13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE.2 At concentrations greater than 100 μM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.
|
-
- HY-134819
-
|
(+)-trans-ML-SI3
|
TRP Channel
|
Cancer
|
|
(1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM) .
|
-
- HY-10588
-
|
(±)-Bay K 8644
|
Calcium Channel
|
Cardiovascular Disease
Neurological Disease
|
|
Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644 . Bay K 8644 is a L-type Ca 2+ channel agonist with an EC50 of 17.3 nM. Bay K 8644 increases Ca 2+ influx through sarcolemmal Ca 2+ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects .
|
-
- HY-126144A
-
|
|
GSK-3
|
Metabolic Disease
|
|
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM .
|
-
- HY-103320B
-
|
|
Others
|
Metabolic Disease
|
|
(1R,2R)-Calhex 231 hydrochloride is the isomer of Calhex 231 hydrochloride (HY-103320A), and can be used as an experimental control. Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca 2+-induced accumulation of [ 3H]inositol phosphate with an IC50 of 0.39 μM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment .
|
-
- HY-106961A
-
|
(Z)-ONO-AP 500-02
|
Others
|
Cardiovascular Disease
|
|
(Z)-ONO 1301 is the isomer of ONO 1301 (HY-106961), and can be used as an experimental control. ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .
|
-
- HY-110258B
-
|
(R,S,R)-LH601A
|
Others
|
Cancer
|
|
(R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity .
|
-
- HY-120139A
-
|
|
Others
|
Cancer
|
|
(R)-KMH-233 is the isomer of KMH-233 (HY-120139), and can be used as an experimental control. KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) .
|
-
- HY-123587A
-
|
|
Others
|
Cancer
|
|
(R)-PR-924 is the isomer of PR-924 (HY-123587), and can be used as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities .
|
-
- HY-153358A
-
|
|
HDAC
|
Cancer
|
|
(S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.
|
-
- HY-N1356A
-
|
|
Others
|
Inflammation/Immunology
|
|
(R)-Reticuline is an isomer of Reticuline (HY-N1356). Reticuline displays anti-inflammatory and cardiovascular effects through JAK2/STAT3 and NF-κB signaling pathways. Salutaridine is a key intermediate in morphine biosynthesis. Salutaridine can be converted from (R)-Reticuline in the poppy plant. The conversion system relies on membrane-bound cytochrome P-450 enzymes and also requires reducing cofactors NADPH, molecular oxygen, etc .
|
-
- HY-B1752
-
|
LY 171555; (-)-LY 141865
|
Others
|
Neurological Disease
|
|
Quinpirole (LY 171555) is a dopamine D2/D3 receptor agonist with activity in reducing hypothalamic norepinephrine concentrations. The effects of Quinpirole are not produced by the selective D1 agonist SKF 38393 or the dextrorotatory isomer of Quinpirole, which lacks D2 agonist activity. By activating D2 receptors, Quinpirole leads to a decrease in dopamine metabolites, a decrease in hypothalamic norepinephrine concentrations, and a possible increase in MHPG sulfate by enhancing norepinephrine release .
|
-
- HY-W339645
-
|
(S)-Naproxen ethyl ester
|
Others
|
Inflammation/Immunology
|
|
Naproxen ethyl ester ((S)-Naproxen ethyl ester) is a nonsteroidal anti-inflammatory drug with activity in relieving pain, fever, swelling and stiffness. Naproxen ethyl ester exerts its effects by inhibiting non-selective cyclooxygenase (COX). The R-(-)-isomer of Naproxen ethyl ester shows stronger immunogenicity, and the Michaelis-Menten parameter of its catalytic reaction is K(M)=6.67 mM, and the catalytic efficiency is 5.8 x 10^4 times higher than that of the non-catalytic reaction .
|
-
- HY-N12834
-
|
|
Others
|
Inflammation/Immunology
Cancer
|
|
Ecdysoside B (compound 6b) is a pregnanoside compound isolated from the plant Ecdysanthera rosea. Ecdysoside B and its derivatives and isomers shows anticancer, immunosuppressive and anti-inflammatory activities. Ecdysoside B shows cytotoxicity to a variety of human tumor cell lines, including PANC-1 (human pancreatic cancer cells), A375 (human melanoma cells) and U87 (brain glioma U87 cells). Ecdysoside B can be used for research in the areas of cancer, immunomodulation and anti-inflammato .
|
-
- HY-138642A
-
|
(Rac)-ARV-471
|
Estrogen Receptor/ERR
PROTACs
|
Cancer
|
|
(Rac)-Vepdegestrant is the isomer of Vepdegestrant (HY-138642). Vepdegestrant ((R)-Lavandulol) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
|
-
- HY-W747563
-
|
11-trans LTD4
|
Others
|
Others
|
|
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.
|
-
- HY-W753927
-
|
C18:2(9E,12Z); C18:2 n-6
|
Endogenous Metabolite
|
Metabolic Disease
|
|
9(E),12(Z)-Octadecadienoic acid is an ω-6 polyunsaturated fatty acid and an isomer of linoleic acid (HY-N0729) that contains a trans double bond at the C9 position. It has been found as a minor component of bovine milk fat and in partially hydrogenated vegetable oils. 9(E),12(Z)-Octadecadienoic acid levels increase in rabbit meat following supplementation with heated sunflower oil, α-tocopheryl acetate, and zinc.
|
-
- HY-13690
-
|
2,4′-DDD; o,p'-DDD
|
Apoptosis
|
Cancer
|
|
Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
|
-
- HY-N0060B
-
|
(E)-Coniferic acid
|
β-catenin
Bcl-2 Family
Ferroptosis
Endogenous Metabolite
|
Cancer
|
|
(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.
|
-
- HY-19831A
-
|
|
Eukaryotic Initiation Factor (eIF)
|
Cancer
|
|
(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity .
|
-
- HY-N0619A
-
|
Mulberroside D
|
TNF Receptor
Interleukin Related
Tyrosinase
|
Inflammation/Immunology
|
|
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
|
-
- HY-151385A
-
|
|
STAT
Interleukin Related
IFNAR
JAK
|
Cancer
|
|
(R,R)-VVD-118313 is the isomer of VVD-118313 (HY-151385). VVD-118313 is a selective JAK1 inhibitor and blocks JAK1-dependent trans-phosphorylation and cytokine signaling. VVD-118313 can be used for research of cancer . (R,R)-VVD-118313 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-14664F
-
|
(3R,5S)-XU 62-320
|
HMG-CoA Reductase (HMGCR)
Autophagy
|
Cancer
|
|
(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .
|
-
- HY-W091788
-
|
|
Others
|
Others
|
|
(2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine is the isomer of 7-Deaza-2'-deoxy-7-iodoadenosine (HY-W048490), and can be used as an experimental control. 7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine .
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-
- HY-124370
-
|
9Z,11E-CLA; Methyl 9(Z),11(E)-octadecadienoate; (9Z,11E)-SFE 19:2
|
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
9(Z),11(E)-Conjugated linoleic acid methyl ester (9Z,11E-CLA; Methyl 9(Z),11(E)-octadecadienoate; (9Z,11E)-SFE 19:2) is an isomer of Linoleic acid (HY-N0729). Conjugated linoleic acid is a bioactive fatty acid, which can improve body composition, enhance immune system function, exhibits anti-cancer and antiatherosclerosis effect .
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-
- HY-118828AS
-
|
(9S,13R)-12-OPDA-d5
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Isotope-Labeled Compounds
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Others
|
|
(9S,13R)-12-OPDA-d5 is an isotopic label of (9S,13R)-12-oxyphytodienoic acid. (9S,13R)-12-Oxophytodienoic acid is an isomer of 12-oxoPDA (HY-118828). (9S,13R)-12-Oxo phytodienoic Acid is a lipoxygenase metabolite in green plant leaves .
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-
- HY-155516A
-
|
|
Potassium Channel
|
Inflammation/Immunology
|
|
cis-KV1.3-IN-1 (Compound cis-18) is a cis-isomer of KV1.3-IN-1 (HY-155516). cis-KV1.3-IN-1 is an inhibitor of the KV1.3 channel. cis-KV1.3-IN-1 (10 μM) inhibits KV1.3 by 25.53% in Xenopus oocytes expressing human hKV1.3 .
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-
- HY-111540B
-
|
(S)-IDO1-IN-5
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
|
(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
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-
- HY-14342A
-
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Others
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Metabolic Disease
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(R)-MK-5046 is the isomer of MK-5046 (HY-14342), and can be used as an experimental control. MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity .
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-
- HY-153220A
-
|
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PROTACs
Btk
|
Inflammation/Immunology
Cancer
|
|
(R)-NX-2127 ((R)-compound 28) is an isomer of the BTK PROTAC degrader NX-2127 (HY-153220) . (R)-NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).
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-
- HY-N6937S1
-
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(R,R)-SDG-d6; (R,R)-LGM2605-d6
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
(R,R)-Secoisolariciresinol diglucoside-d6 is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
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-
- HY-100218C
-
|
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Ferroptosis
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Cancer
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|
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .
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-
- HY-111817A
-
|
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Parasite
|
Infection
|
|
(Rac)-ACT-451840 is an isomer of ACT-451840 that exhibits significant antimalarial effects. (Rac)-ACT-451840 exhibits significant antimalarial activity against P. berghei-infected mice at a dose of 20 mg/kg (ED90=13 mg/kg), and has an inhibitory effect at a dose of 300 mg/kg. The ED90 of (Rac)-ACT-451840 in the P. falciparum humanized immunodeficient mouse model is 3.7 mg/kg. (Rac)-ACT-451840 is similar to artemisinin, with a rapid onset of action but requires repeated high doses.
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-
- HY-N6937R
-
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Others
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Inflammation/Immunology
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(R,R)-Secoisolariciresinol diglucoside (Standard) is the analytical standard of (R,R)-Secoisolariciresinol diglucoside. This product is intended for research and analytical applications. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
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-
- HY-135023R
-
|
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Cytochrome P450
Prostaglandin Receptor
|
Cancer
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|
5-trans-PGE2 (Standard) is the analytical standard of 5-trans-PGE2. This product is intended for research and analytical applications. 5-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase). This process is involved in the growth and development of breast cancer .
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-
- HY-131527
-
|
N-Desmethyl Venlafaxine hydrochloride; Wy 45494
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Others
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Metabolic Disease
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Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
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-
- HY-126031
-
|
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Others
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Others
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(R)-KT109 is a highly potent inhibitor of diacylglycerol lipase β (DAGLβ) with an IC50 of 0.79 nM and effectively blocks DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol. Additionally, it demonstrates inhibitory activity against α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 of 2.51 nM, exhibiting greater potency for DAGLβ, DAGLα, and ABHD6 compared to its (S) isomer, (S)-KT109.
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-
- HY-P5327
-
|
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Bcl-2 Family
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Others
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r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)
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- HY-10035A
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Others
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Neurological Disease
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(R)-TTA-P2 is the isomer of TTA-P2 (HY-10035), and can be used as an experimental control. TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease .
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-
- HY-50707
-
|
(Rac)-T-Type calcium channel inhibitor
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Others
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Neurological Disease
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(Rac)-TTA-P2 is the isomer of TTA-P2 (HY-10035), and can be used as an experimental control. TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease .
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-
- HY-B0267BS
-
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mAChR
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Oxybutynin-d5 hydrochloride is deuterated labeled (R)-Oxybutynin hydrochloride (HY-B0267B). (R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction . (R)-Oxybutynin hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-N12885
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Others
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Endocrinology
|
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(11Z,13E)-Hexadecadienal is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) when mixed with (11Z,13Z)-hexadecadien-1-ol, (11Z,13E)-hexadecadien-1-ol, (3Z,6Z,9Z,12Z,15Z)-tricosapentaene (C23 pentaene) .
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-
- HY-13690R
-
|
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Apoptosis
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Cancer
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Mitotane (Standard) is the analytical standard of Mitotane. This product is intended for research and analytical applications. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
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-
- HY-125784B
-
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(S)-Viloxazin hydrochloride; (S)-Emovit hydrochloride
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Others
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Neurological Disease
|
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(S)-Viloxazine hydrochloride is the isomer of Viloxazine hydrochloride (HY-125784). Viloxazine hydrochloride is the hydrochloride salt form of Viloxazine (HY-W380450). Viloxazine (Viloxazin) hydrochloride is a norepinephrine reuptake inhibitor and a potent 5-HT2C agonist agent and 5-HT2B antagonist，EC50 for 5-HT2C b> is 32 μM，and the IC50 for 5-HT2B is 27 μM. Viloxazine hydrochloride's mechanism of action primarily involves serotonergic and noradrenergic pathways. Viloxazine hydrochloride is used in antidepressant research .
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- HY-117215
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Biochemical Assay Reagents
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Others
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Beta-Ocimene is a naturally occurring organic compound that belongs to the terpene family. It exists as a mixture of three isomers: cis β-Ocimene, trans β-Ocimene and myrcene-like β-Ocimene. It has a pleasant, sweet herbaceous scent and is found in many plants, including mint, basil, parsley, and kumquat. β-Ocimene is widely used in the flavor and fragrance industry due to its characteristic aroma and taste. It also has potential applications in agriculture as natural insect repellants and pheromones that attract beneficial insects. β-Ocimene has potential anti-inflammatory and anticancer activities.
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-
- HY-13690S1
-
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2,4′-DDD-13C6; o,p'-DDD-13C6
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Apoptosis
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Cancer
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|
Mitotane- 13C6 is the 13C labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].
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-
- HY-13690S2
-
|
2,4′-DDD-d8; o,p'-DDD-d8
|
Apoptosis
|
Cancer
|
|
Mitotane-d8 is the deuterium labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].
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-
- HY-N0060BR
-
|
|
β-catenin
Bcl-2 Family
Ferroptosis
Endogenous Metabolite
|
Cancer
|
|
(E)-Ferulic acid (Standard) is the analytical standard of (E)-Ferulic acid. This product is intended for research and analytical applications. (E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.
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-
- HY-N0060BS
-
|
(E)-Coniferic acid-d3
|
β-catenin
Bcl-2 Family
Ferroptosis
Endogenous Metabolite
|
Cancer
|
|
(E)-Ferulic acid-d3 is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
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-
- HY-112371
-
|
|
CDK
|
Cancer
|
|
(S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40 μM) .
|
-
- HY-114571
-
|
cis-VX-222
|
DNA/RNA Synthesis
HCV
|
Infection
|
|
cis-Lomibuvir (cis-VX-222) is the cis-isomer of Lomibuvir. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis . cis-Lomibuvir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-W007223
-
|
D-5-HTP; 5-Hydroxy-D-tryptophan
|
5-HT Receptor
|
Neurological Disease
|
|
D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range .
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-
- HY-W002530A
-
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Biochemical Assay Reagents
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Others
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(1R,2R)-1-Aminoindan-2-ol is the isomer of (1S,2R)-1-Aminoindan-2-ol (HY-W002530), and can be used as an experimental control. (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-100072
-
|
Methyl (2E,4E,6Z)-decatrienoate
|
Others
|
Infection
|
|
(2E,4E,6Z)-Methyl deca-2,4,6-trienoate (Methyl (2E,4E,6Z)-decatrienoate) is the aggregation pheromone of the brown-winged green bug, Plautia stali. (2E,4E,6Z)-Methyl deca-2,4,6-trienoate exposed to daylight in solutions and/or on dispensers used for field trapping can readily isomerize to form complex mixtures of isomers, thus causing a concern about lure stability and longevity .
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-
- HY-126247B
-
|
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Others
|
Cancer
|
|
(R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
|
-
- HY-13690S3
-
|
2,4′-DDD-13C12; o,p'-DDD-13C12
|
Isotope-Labeled Compounds
Apoptosis
|
Cancer
|
|
Mitotane- 13C12 (2,4′-DDD- 13C12) is 13C labeled Mitotane. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
|
-
- HY-112289B
-
|
|
Isocitrate Dehydrogenase (IDH)
|
Cancer
|
|
(1R)-IDH889 is the isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H, IDH1 R132C and IDH1 wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM .
|
-
- HY-N7864
-
|
all-cis-4,7,10,13,16-Docosapentaenoic acid
|
Biochemical Assay Reagents
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Others
|
|
Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.
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-
- HY-117215R
-
|
|
Biochemical Assay Reagents
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Others
|
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β-Ocimene (Standard) is the analytical standard of β-Ocimene. This product is intended for research and analytical applications. Beta-Ocimene is a naturally occurring organic compound that belongs to the terpene family. It exists as a mixture of three isomers: cis β-Ocimene, trans β-Ocimene and myrcene-like β-Ocimene. It has a pleasant, sweet herbaceous scent and is found in many plants, including mint, basil, parsley, and kumquat. β-Ocimene is widely used in the flavor and fragrance industry due to its characteristic aroma and taste. It also has potential applications in agriculture as natural insect repellants and pheromones that attract beneficial insects. β-Ocimene has potential anti-inflammatory and anticancer activities.
|
-
- HY-W414548
-
|
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Others
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Neurological Disease
Metabolic Disease
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|
7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC).
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-
- HY-120877A
-
|
|
MARK
Salt-inducible Kinase (SIK)
AMPK
Apoptosis
|
Cancer
|
|
(R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .
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-
- HY-19471
-
|
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Others
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Cancer
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|
(rac)-ZK-304709 is an isomer of ZK-304709. It is a first-in-class oral multi-target tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (Cdks), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. It directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. In an orthotopic BON tumor model, (rac)-ZK-304709 reduced primary tumor growth by 80% and reduced tumor microvascular density. These results suggest that (rac)-ZK-304709 can effectively control tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may be a potential agent for the treatment of NET.
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-
- HY-116161
-
|
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Others
|
Cardiovascular Disease
Others
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|
15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.
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-
- HY-117074
-
|
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Others
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Infection
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|
BMS-247243 is a β-lactam antibiotic against methicillin-resistant Staphylococcus aureus. This section introduces its synthesis method and biological properties. A practical synthetic method was developed to exchange iodide ions with chloride ions to form 4-thiopyridinol 6b with C-3 side chain, thereby effectively synthesizing methyl ester 12b with C-7 side chain. The reaction of 14 with methylthiolate lithium salt was catalyzed by Bu4NCl to form methyl ester 12b in high yield. Reaction with thiolate dianion gave the corresponding Michael addition byproduct, resulting in a decrease in the quality of thermodynamic product 12b. The diester 17 was synthesized by acid chlorination acylation of 16 with 12b in a two-phase system, avoiding the troublesome deprotection work such as using DCC or EDAC. During the TFA reaction to remove the protecting group 17, the bis acid 20 was unexpectedly obtained. The bis acid 19 reacted with 4-thiopyridinol 6b to form BMS-247243 in moderate yield. Alternatively, efficient coupling of diester 17 with 4-thiopyridinol 6b afforded crystalline diester 21 with little contamination from isomer 22. Double deprotection of diester 21 followed by crystallization afforded the bis-zwitterion BMS-247243 in high yield.
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- HY-117947
-
|
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Others
|
Cancer
|
|
(R)-OR-S1 is an isomer of OR-S1. The dual ZH1/2 inhibitors OR-S1 and OR-S2 exhibit strong inhibitory activity against both EZH1 and EZH2. OR-S1 and OR-S2 are highly selective methyltransferase inhibitors against EZH1 and EZH2, and they have very similar molecular features. Therefore, we investigated the effect of OR-S1 on acute myeloid leukemia (AML). We found that OR-S1 was able to induce cell differentiation and apoptosis in AML cells. These findings encouraged us to investigate whether functional LT-HSCs could survive PRC2-targeted therapy with OR-S1 or OR-S1 combined with cytarabine. The results showed that OR-S1 did not cause significant myelosuppression, and BM cells treated with the combination therapy were able to undergo normal hematopoiesis even 4 months after treatment. Therefore, temporary inhibition of EZH1 and EZH2 is clinically tolerable, making this combination therapy suitable for AML patients. AML is generally believed to originate from myeloid progenitor cells that inherit a large number of biological properties.
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D1249
-
|
|
Fluorescent Dyes/Probes
|
|
Calcein mixture of isomers is a calcium-dependent fluorescent molecule. Calcein mixture of isomers can be used to study bone metabolism (in vivo) and to stain depressed areas (in vitro). Calcein mixture of isomers can also be used for fluorometry and EDTA titration of calcium.
|
-
- HY-D1306
-
-
- HY-D0029
-
|
5(6)-AFM; Fluoresceinamine mixed Isomers
|
Fluorescent Dyes/Probes
|
|
5(6)-Aminofluorescein (5(6)-AFM) is a a precursor for synthesis of 5(6)-FITC (HY-15941). 5(6)-FITC is an amine-reactive derivative of fluorescein dye.
|
-
- HY-15940
-
|
5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed Isomers
|
Fluorescent Dyes/Probes
|
|
5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .
|
-
- HY-D1335
-
-
- HY-151774
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA hydrazide (6-isomer) is a click chemistry reagent that can be coupled to carbonyl compounds. The dye hydrazide in TAMRA hydrazide (6-isomer) labels carbonyl compounds such as aldehydes and ketones. TAMRA in TAMRA hydrazide (6-isomer) is a xanthene red fluorophore that reacts with terminal alkynes .
|
-
- HY-151690
-
|
|
Fluorescent Dyes/Probes
|
|
FAM hydrazide, 6-isomer is a hydrazide derivative of fluorescein (FAM). FAM is a xanthene dye, a parent of fluorescein dye series. FAM hydrazide, 6-isomer can be used for the labeling of carbonyl compounds, aldehydes, and ketones .
|
-
- HY-132264
-
|
|
Fluorescent Dyes/Probes
|
|
FAM hydrazide, 6-isomer hydrochloride is a hydrazide derivative of fluorescein (FAM). FAM is a xanthene dye, a parent of fluorescein dye series. FAM hydrazide, 6-isomer hydrochloride can be used for the labeling of carbonyl compounds, aldehydes, and ketones .
|
-
- HY-D1311
-
|
|
Dyes
|
|
R110 azide, 6-isomer is an isomer of rhodamine dye with an azide group that labels DNA fragments. It enables visualization of the results of capillary electrophoresis genotyping experiments and gel shift experiments.
|
-
- HY-D1893
-
|
|
Fluorescent Dyes/Probes
|
|
HEX azide, 6-isomer, a derivate of fluorescent dye hexachlorofluorescein (HEX), can be used for labeling oligonucleotides .
|
-
- HY-W414549
-
|
|
Fluorescent Dyes/Probes
|
|
FAM alkyne, 6-isomer is a click chemistry regent that can be used in 1,3-dipolar cycloaddition with azido-labeled compound .
|
-
- HY-D1756
-
|
|
Fluorescent Dyes/Probes
|
|
ROX NHS ester, 6-isomer is a highly fluorescent, and photostable rhodamine dye for various applications. ROX labeled oligonucleotide probes are often used in qPCR, and qPCR instruments have ROX channel. This is reactive dye for the labeling of amino-groups in peptides, proteins, and amino-oligonucleotides. Pure single isomer.
|
-
- HY-15941
-
|
Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- Isomers
|
Fluorescent Dyes/Probes
|
|
5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .
|
-
- HY-D1336
-
|
|
Fluorescent Dyes/Probes
|
|
FAM amine, 6-isomer is a fluorescein derivative with an amine group and contains an isomer of the fluorophore. Can be used to modify biomolecules through enzymatic transamination. Its fatty amine groups can also react with electrophiles such as activated esters. The amine can also be conjugated to carbonyl compounds (aldehydes and ketones) by reductive amination.
|
-
- HY-D1900
-
|
|
Fluorescent Dyes/Probes
|
|
VIC azide, 6-isomer is a VIC derivative that can be used for conjugating VIC to other molecules. VIC can be used for labeling oligonucleotides at the 5’-end .
|
-
- HY-D1899
-
|
|
Fluorescent Dyes/Probes
|
|
VIC phosphoramidite, 6-isomer is a VIC derivative that can be used for conjugating VIC to other molecules. VIC can be used for labeling oligonucleotides at the 5’-end .
|
-
- HY-15937
-
|
5(6)-Carboxyfluorescein N-hydroxysuccinimide ester; 5(6)-Carboxyfluorescein succinimidyl ester mixed Isomers
|
Fluorescent Dyes/Probes
|
|
5(6)-FAM SE is a green fluorescent dye widely used for protein labeling.
|
-
- HY-15939
-
-
- HY-66021
-
6-FAM
1 Publications Verification
6-Carboxyfluorescein
|
Oligonucleotide Labeling
|
|
6-FAM (6-Carboxyfluorescein) is an isomer of carboxyfluorescein and is mainly used for sequencing and labeling of nucleic acids.
|
-
- HY-D1774
-
-
- HY-D1314
-
|
6-FAM azide
|
Dyes
|
|
FAM azide, 6-isomer (6-FAM azide), a fluorescent dye, is a click chemistry reagent containing an azide group . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-D0723
-
|
5(6)-Carboxytetramethylrhodamine N-succinimidyl ester
|
Oligonucleotide Labeling
|
|
5(6)-TAMRA SE is the amine-reactive, mixed isomer form of TAMRA, which is a dye for oligonucleotide labeling and automated DNA sequencing applications.
|
-
- HY-66022
-
5-FAM
3 Publications Verification
5-Carboxyfluorescein
|
Fluorescent Dyes/Probes
|
|
5-FAM (5-Carboxyfluorescein) is a green fluorescent reagent used for in situ labeling peptides, proteins and nucleotides. 5-FAM is a single isomer with Ex/Em of 490 nm/520 nm .
|
-
- HY-15938
-
|
|
Fluorescent Dyes/Probes
|
|
5-FAM SE is a single isomer, is a fluorescent labeling reagent used for labeling peptides, proteins and nucleotides. 5-FAM SE can react with amines and can yield stable amine conjugates .
|
| Cat. No. |
Product Name |
Type |
-
- HY-W589849
-
|
FITC Isomer Ⅱ
|
Biochemical Assay Reagents
|
|
6-Isothiocyanato-Fluorescein (FITC Isomer Ⅱ) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W012550
-
|
|
Biochemical Assay Reagents
|
|
D-Carnitine is an orally available isomer of the essential nutrient L-carnitine that promotes long-chain fatty acid transport into the mitochondrial matrix for beta-oxidation. D-Carnitine has antiparasitic activity .
|
-
- HY-117215
-
|
|
Biochemical Assay Reagents
|
|
Beta-Ocimene is a naturally occurring organic compound that belongs to the terpene family. It exists as a mixture of three isomers: cis β-Ocimene, trans β-Ocimene and myrcene-like β-Ocimene. It has a pleasant, sweet herbaceous scent and is found in many plants, including mint, basil, parsley, and kumquat. β-Ocimene is widely used in the flavor and fragrance industry due to its characteristic aroma and taste. It also has potential applications in agriculture as natural insect repellants and pheromones that attract beneficial insects. β-Ocimene has potential anti-inflammatory and anticancer activities.
|
-
- HY-N7864
-
|
all-cis-4,7,10,13,16-Docosapentaenoic acid
|
Cell Assay Reagents
|
|
Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.
|
-
- HY-W763562
-
|
|
Co-solvents
|
|
Tridecanol (mixture of isomers) is a biochemical reagent.
|
-
- HY-159669
-
|
|
Cell Assay Reagents
|
Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .
|
-
- HY-W250128
-
|
DDSA (mixture of Isomers)
|
Biochemical Assay Reagents
|
|
2-Dodecen-1-Ylsuccinic Anhydride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Dodecenylsuccinic anhydride (mixture of isomers) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W776824
-
|
|
Carbohydrates
|
|
2-Phthalimidolactosamine,heptaacetate (mixture of isomers) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-N7092A
-
|
L-arabino-2-Hexulose, 95%
|
Carbohydrates
|
|
L-(+)-Fructose, 95% (L-arabino-2-Hexulose, 95%) is the L-isomer of D-Fructose (HY-N7092). L-(+)-Fructose, 95% is involved in glycolysis and gluconeogenesis, and can be used to study photosynthesis and carbohydrate storage in plant biology. L-(+)-Fructose, 95% can be used to investigate the activity of fructokinase and other fructose-metabolizing enzymes .
|
-
- HY-117215R
-
|
|
Biochemical Assay Reagents
|
|
β-Ocimene (Standard) is the analytical standard of β-Ocimene. This product is intended for research and analytical applications. Beta-Ocimene is a naturally occurring organic compound that belongs to the terpene family. It exists as a mixture of three isomers: cis β-Ocimene, trans β-Ocimene and myrcene-like β-Ocimene. It has a pleasant, sweet herbaceous scent and is found in many plants, including mint, basil, parsley, and kumquat. β-Ocimene is widely used in the flavor and fragrance industry due to its characteristic aroma and taste. It also has potential applications in agriculture as natural insect repellants and pheromones that attract beneficial insects. β-Ocimene has potential anti-inflammatory and anticancer activities.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-106359A
-
|
RDP-58 acetate
|
TNF Receptor
IFNAR
Reactive Oxygen Species
|
Cancer
|
|
Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis .
|
-
- HY-W002299
-
|
Boc-D-Leu-OH hydrate
|
Amino Acid Derivatives
|
Neurological Disease
|
|
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine. D-Leucine is an unnatural isomer of L-Leucine that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect .
|
-
- HY-106359
-
-
- HY-P5327
-
|
|
Bcl-2 Family
|
Others
|
|
r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)
|
-
- HY-W007223
-
|
D-5-HTP; 5-Hydroxy-D-tryptophan
|
5-HT Receptor
|
Neurological Disease
|
|
D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N0886R
-
-
- HY-N7731A
-
-
- HY-B1453
-
-
- HY-N1400
-
-
- HY-N1418A
-
-
- HY-113334
-
-
- HY-W002272
-
-
- HY-N0363
-
-
- HY-W016781
-
-
- HY-N8084
-
-
- HY-N1966
-
-
- HY-N0471
-
-
- HY-N0363A
-
-
- HY-W067479
-
-
- HY-N11636
-
-
- HY-W010098R
-
-
- HY-N5056
-
-
- HY-N1394R
-
-
- HY-40135R
-
-
- HY-N14990
-
-
- HY-129770
-
-
- HY-145806
-
-
- HY-76082R
-
-
- HY-N0557R
-
-
- HY-W012708
-
-
- HY-N0445
-
-
- HY-N0471A
-
-
- HY-Y0079R
-
-
- HY-N12883
-
-
- HY-75087
-
-
- HY-16950A
-
-
- HY-N2059
-
-
- HY-Y0444
-
-
- HY-W016814R
-
-
- HY-Y0017R
-
-
- HY-W017277
-
-
- HY-15464
-
-
- HY-N0351
-
-
- HY-113061
-
-
- HY-142050
-
-
- HY-N0363R
-
-
- HY-N0326
-
-
- HY-N12955
-
-
- HY-N0363AR
-
|
|
Structural Classification
other families
Source classification
Coumarins
Phenylpropanoids
Plants
|
Fungal
|
|
(+)-Columbianetin acetate (Standard) is the analytical standard of (+)-Columbianetin acetate. This product is intended for research and analytical applications. (S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity .
|
-
- HY-N1778A
-
-
- HY-N1867
-
-
- HY-N0471R
-
-
- HY-B1000A
-
-
- HY-N5056R
-
-
- HY-N8356
-
-
- HY-N8356A
-
-
- HY-122938
-
-
- HY-N0351A
-
-
- HY-N0471AR
-
-
- HY-W017277R
-
|
|
Natural Products
Labiatae
Source classification
Erythrina poeppigiana
Plants
|
Others
|
|
(+)-Menthol (Standard) is the analytical standard of (+)-Menthol. This product is intended for research and analytical applications. (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .
|
-
- HY-W018555
-
-
- HY-113061R
-
-
- HY-N5097
-
-
- HY-N0351R
-
-
- HY-129555
-
-
- HY-N3841A
-
-
- HY-N0326R
-
-
- HY-N6937
-
-
- HY-16950AR
-
-
- HY-B1000AR
-
-
- HY-N1356A
-
-
- HY-N12834
-
-
- HY-N0060B
-
-
- HY-N0619A
-
-
- HY-N6937R
-
|
|
Structural Classification
Linum usitatissimum Linn.
Linaceae
Source classification
Lignans
Phenylpropanoids
Plants
|
Others
|
|
(R,R)-Secoisolariciresinol diglucoside (Standard) is the analytical standard of (R,R)-Secoisolariciresinol diglucoside. This product is intended for research and analytical applications. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
|
-
- HY-N12885
-
|
|
Structural Classification
Natural Products
Animals
Source classification
|
Others
|
|
(11Z,13E)-Hexadecadienal is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) when mixed with (11Z,13Z)-hexadecadien-1-ol, (11Z,13E)-hexadecadien-1-ol, (3Z,6Z,9Z,12Z,15Z)-tricosapentaene (C23 pentaene) .
|
-
- HY-N0060BR
-
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W018772S15
-
|
|
|
D-Ribose(mixture of isomers)- 13C5 isomers)- 13C5 is the 13C labeled D-Ribose(mixture of isomers)[1]. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner[1].
|
-
-
- HY-132637S
-
|
|
|
Chlorfenvinphos-d10(Mixture of cis-trans isomers) is the deuterium labeled Chlorfenvinphos (Mixture of cis-trans isomers)[1].
|
-
-
- HY-132485S
-
|
|
|
N-Methyl Pantoprazole-d3 (Mixture of 1 and 3 isomers) is the deuterium labeled N-Methyl Pantoprazole (Mixture of 1 and 3 isomers) .
|
-
-
- HY-143940S
-
|
|
|
Cabergoline isomer-d6 is the deuterium labeled Cabergoline isomer[1].
|
-
-
- HY-B0203BS2
-
|
|
|
(Rac)-Nebivolol-d2, 15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
|
-
-
- HY-143921S
-
|
|
|
Almorexant (αS,1S) isomer- 13C,d3 is the 13C- and deuterium labeled Almorexant (αS,1S) isomer[1].
|
-
-
- HY-W018772S16
-
|
|
|
D-Ribose-1,2- 13C2 is the 13C labled D-Ribose(mixture of isomers) (HY-W018772) . D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .
|
-
-
- HY-132475S
-
|
|
|
rac Duloxetine 3-Thiophene Isomer-d3 Oxalate is a stable isotope of Duloxetine.
|
-
-
- HY-B1617AS1
-
|
|
|
Zuclomiphene-d5 (citrate) is the deuterium labeled Zuclomiphene citrate[1]. Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[2][3][4][5].
|
-
-
- HY-160220S
-
|
|
|
KRAS inhibitor-23 (Isomer 2 of compound i) is a potent inhibitor of KRAS that plays an important role in cancer research .
|
-
-
- HY-W010098S
-
|
|
|
Terephthalic acid-d4 is the deuterium labeled Terephthalic acid. Terephthalic acid is one isomer of the three phthalic, a precursor to the polyester PET, used to make clothing and plastic bottles.
|
-
-
- HY-N0326S7
-
|
|
|
L-Methionine-d3 is the deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
-
- HY-N0326S8
-
|
|
|
L-Methionine-d8 is the deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
-
- HY-N0326S10
-
|
|
|
L-Methionine-d4 is the deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
-
- HY-112019
-
|
|
|
L-Methionine- 34S is a 34S-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
-
- HY-N0351S
-
|
|
|
p-Coumaric acid- 13C3 is the 13C-labeled p-Coumaric acid. p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities.
|
-
-
- HY-W010098S1
-
|
|
|
Terephthalic acid- 13C2 is the 13C-labeled Terephthalic acid. Terephthalic acid is one isomer of the three phthalic, a precursor to the polyester PET, used to make clothing and plastic bottles.
|
-
-
- HY-N0326S
-
|
|
|
L-Methionine- 15N is the 15N-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
|
-
-
- HY-124414S
-
|
|
|
4'-Hydroxytamoxifen-d6 (contains up to 10% E isomer) is deuterium labeled 4'-Hydroxy Tamoxifen. 4'-Hydroxytamoxifen is a metabolite of Tamoxifen.
|
-
-
- HY-N0326S3
-
|
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L-Methionine- 13C is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-40135S
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L-Hydroxyproline-d3 is the deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
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- HY-N0326S5
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L-Methionine- 13C5 is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-W654232
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L-Hydroxyproline-d4 is deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals .
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- HY-B1674S
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(±)-Leucine-d10 is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%[1].
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- HY-N2341S
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Palmitelaidic acid-d13 is the deuterium labeled Palmitelaidic Acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
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- HY-N0326S4
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L-Methionine-1- 13C is the 13C-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-76082S
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1 Publications Verification
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L-Pyroglutamic acid-d5 is the deuterium labeled L-Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
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- HY-B1674S4
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(±)-Leucine-d7 is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%[1].
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- HY-N1394S
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p-Anisic acid- 13C6 is the 13C-labeled p-Anisic acid. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties[1].
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- HY-N0326S1
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L-Methionine- 13C,d5 is the 13C- and deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-N0326S2
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L-Methionine- 13C,d3 is the 13C- and deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-Y0079S
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D-Phenylalanine-d5 is the deuterium labeled D-Phenylalanine. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014[1].
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- HY-Y0079S1
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D-Phenylalanine-d8 is the deuterium labeled D-Phenylalanine. D-Phenylalanine is the synthetic dextro isomer of phenylalanine. D-Phenylalanine inhibits biofilm development of Pseudoalteromonas sp. SC2014[1].
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- HY-I1060S
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L-Alloisoleucine-d10 is the deuterium labeled L-Alloisoleucine. L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).
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- HY-N0326S6
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L-Methionine- 13C5, 15N is the 13C- and 15N-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-N0326S9
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L-Methionine- 15N,d8 is the deuterium and 15N-labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
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- HY-Y0017S
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L-Norleucine-d9 is the deuterium labeled L-Norleucine. L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
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- HY-N1394S1
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p-Anisic acid-d4 is the deuterium labeled p-Anisic acid[1]. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties[2].
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- HY-78139S
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L-Xylose-1- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
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- HY-78139S1
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L-Xylose-2- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
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- HY-78139S2
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L-Xylose-5- 13C is the 13C labeled L-Xylose. L-Xylose (L-(-)-Xylose) is the levo-isomer of Xylose. Xylose is classified as a monosaccharide of the aldopentose type[1][2].
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- HY-N0351S1
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p-Coumaric acid-d6 is the deuterium labeled p-Coumaric acid (HY-N0351). p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities[1][2].
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- HY-76082S1
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L-Pyroglutamic acid-13C5 is a deuterated labeled L-Pyroglutamic acid . L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
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- HY-B1453S1
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(±)-Carnitine-d9 (chloride) is the deuterium labeled (±)-Carnitine chloride. (±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.
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- HY-W010589S
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H-Abu-OH-d3 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
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- HY-W010589S1
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H-Abu-OH-d2 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
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- HY-W010589S2
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H-Abu-OH-d6 is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
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- HY-N0471S
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L-Hyoscyamine-d3 is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].
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- HY-B1617AS
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Zuclomiphene-d4 (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].
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- HY-W016814S
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(Z)-Aconitic acid- 13C6 is the 13C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
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- HY-16950BS
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(E)-4-Hydroxytamoxifen-d5 ((E)-Afimoxifene-d5) is the deuterium labeled (E)-4-Hydroxytamoxifen. (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator.
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- HY-Y0444S
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D-Tyrosine-d2 is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].
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- HY-Y0444S1
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D-Tyrosine-d4 is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].
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- HY-Y0444S2
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D-Tyrosine-d7 is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].
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- HY-113061S
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Pseudouridine- 18O is the 18O labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.
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- HY-132451S
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(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit is the deuterium labeled (R,S)-4-Hydroxy Cyclophosphamide Preparation Kit. (R,S)-4-Hydroxy Cyclophosphamide is an isomer of 4-Hydroxycyclophosphamide, the active metabolite of the cytotoxic alkylating agent Cyclophosphamide (HY-17420) .
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- HY-118828AS
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(9S,13R)-12-OPDA-d5 is an isotopic label of (9S,13R)-12-oxyphytodienoic acid. (9S,13R)-12-Oxophytodienoic acid is an isomer of 12-oxoPDA (HY-118828). (9S,13R)-12-Oxo phytodienoic Acid is a lipoxygenase metabolite in green plant leaves .
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- HY-N6937S1
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(R,R)-Secoisolariciresinol diglucoside-d6 is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
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- HY-B0267BS
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Oxybutynin-d5 hydrochloride is deuterated labeled (R)-Oxybutynin hydrochloride (HY-B0267B). (R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used for researching incontinence due to neurogenic bladder dysfunction . (R)-Oxybutynin hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-13690S1
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Mitotane- 13C6 is the 13C labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].
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- HY-13690S2
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Mitotane-d8 is the deuterium labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].
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- HY-N0060BS
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(E)-Ferulic acid-d3 is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
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- HY-13690S3
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Mitotane- 13C12 (2,4′-DDD- 13C12) is 13C labeled Mitotane. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
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| Cat. No. |
Product Name |
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Classification |
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- HY-D1306
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Azide
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TAMRA azide, 6-isomer is an isomer of TAMRA, a xanthene dye with orange emission.
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- HY-151857
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Azide
Labeling and Fluorescence Imaging
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TAMRA azide, 5-isomer is a click chemical containing azide groups that can be used as a linker for the orange dye TAMRA. The azide group of TAMRA Azide, 5-isomer enables copper-catalyzed click chemical reactions with alkynes, DBCO, and BCN . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-D1314
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6-FAM azide
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Azide
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FAM azide, 6-isomer (6-FAM azide), a fluorescent dye, is a click chemistry reagent containing an azide group . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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- HY-W250128
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DDSA (mixture of Isomers)
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Alkynes
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2-Dodecen-1-Ylsuccinic Anhydride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Dodecenylsuccinic anhydride (mixture of isomers) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-D1311
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Azide
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R110 azide, 6-isomer is an isomer of rhodamine dye with an azide group that labels DNA fragments. It enables visualization of the results of capillary electrophoresis genotyping experiments and gel shift experiments.
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- HY-W414549
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Alkynes
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FAM alkyne, 6-isomer is a click chemistry regent that can be used in 1,3-dipolar cycloaddition with azido-labeled compound .
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- HY-151680
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Labeling and Fluorescence Imaging
Alkynes
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TAMRA alkyne, 6-isomer is a linker of TAMRA which is a xanthene dye with orange emission that is commonly used for oligonucleotide labeling and amino acid sequencing. The addition of the alkyne groups allows for it to be reacted with an azide for copper-catalyzed Click Chemistry .
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| Cat. No. |
Product Name |
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Classification |
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- HY-B0172B
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Cholesterol
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Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate .
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- HY-113061
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Nucleosides and their Analogs
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Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation .
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