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Results for "

acetylcholine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mAChR (124) nAChR (158) 5-HT Receptor (13) Acyltransferase (1) Adenosine Receptor (4) Adrenergic Receptor (5) Amyloid-β (3) Antibiotic (8) Apoptosis (6) Autophagy (5) Bacterial (11) Biochemical Assay Reagents (6) Calcium Channel (16) Caspase (1) Cholinesterase (ChE) (36) COX (1) CXCR (4) DAGL (1) Dengue Virus (2) DNA/RNA Synthesis (1) Dopamine Receptor (7) Drug Derivative (1) Drug Metabolite (1) Endogenous Metabolite (29) Endothelin Receptor (1) ERK (2) Flavivirus (2) GABA Receptor (1) GPR35 (4) HDAC (2) Histamine Receptor (6) Histone Methyltransferase (1) HIV (2) HSV (2) iGluR (11) Insecticide (1) Isotope-Labeled Compounds (21) Kisspeptin Receptor (3) MAGL (1) Mitophagy (2) MMP (1) mTOR (1) NADPH Oxidase (1) Neurokinin Receptor (1) NOD-like Receptor (NLR) (2) Opioid Receptor (1) p38 MAPK (2) Parasite (20) Phosphodiesterase (PDE) (2) Phospholipase (1) Potassium Channel (5) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (1) Reactive Oxygen Species (1) SARS-CoV (3) Sigma Receptor (2) Thyroid Hormone Receptor (1) Topoisomerase (1) Trace Amine-associated Receptor (TAAR) (1) TRP Channel (1)
By Research Areas:	Cancer (54) Cardiovascular Disease (22) Endocrinology (7) Infection (28) Inflammation/Immunology (40) Metabolic Disease (17) Neurological Disease (279)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Antisense Oligonucleotides (2) Cholesterol (1)

394

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: nAChR mAChR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0282

Acetylcholine chloride 10+ Cited Publications ACh chloride	nAChR Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-101086

Acetylcholine iodide 10+ Cited Publications ACh iodide	Endogenous Metabolite mAChR	Neurological Disease Endocrinology
Acetylcholine iodide is a muscarinic receptor modulator. Acetylcholine iodide specifically binds to muscarinic receptors, inhibits sodium absorption, and induces chloride secretion. Acetylcholine iodide changes intestinal ion transport, enhances intestinal secretory function, induces or maintains mammary gland development and lactation. Acetylcholine iodide can be used for intestinal ion transport regulation and mammary gland physiological function research .

HY-B0282S1

Acetylcholine-d9 chloride ACh-d₉(chloride)	nAChR Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Acetylcholine-d₉ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-B0282S

Acetylcholine-d4 chloride ACh-d₄ (chloride)	nAChR Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Acetylcholine-d₄ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-B0282AS

Acetylcholine-d9 bromide ACh-d₉ bromide	nAChR Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
Acetylcholine-d₉ (bromide) is the deuterium labeled Acetylcholine bromide .

HY-B0282AS1

Acetylcholine-d4 bromide ACh-d₄ bromide	nAChR Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
Acetylcholine-d₄ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-B0282AS2

Acetylcholine-d13 bromide ACh-d₁₃ bromide	nAChR Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
Acetylcholine-d₁₃ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-B0282AS3

Acetylcholine-d16 bromide ACh-d₁₆ bromide	nAChR Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
Acetylcholine-d₁₆ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-B0282R

Acetylcholine chloride (Standard)	nAChR Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Acetylcholine (chloride) (Standard) is the analytical standard of Acetylcholine (chloride). This product is intended for research and analytical applications. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-134952

Acetylcholine perchlorate	Biochemical Assay Reagents	Others
Acetylcholine perchlorate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-B0282A

Acetylcholine bromide 10+ Cited Publications ACh bromide	Biochemical Assay Reagents	Others Cancer
Acetylcholine bromide is an organic choline salt compound commonly used in neurophysiology and pharmacology experiments. It plays an important role in the nervous system, acting as a neurotransmitter that transmits signals and regulates many important physiological functions. Due to its special biological activity, Acetylcholine bromide is widely used in the study of neurotransmitters, nerve damage and muscle movement.

HY-P2860A

Acetylcholinesterase, Electric eel	Cholinesterase (ChE)	Neurological Disease
Acetylcholinesterase, Electric eel is a cholinergic enzyme that is mainly found in neuromuscular junctions and cholinergic chemical synapses and is often used in biochemical research. Acetylcholinesterase, Electric eel can catalyze the decomposition or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetic acid and choline. The main function of Acetylcholinesterase, Electric eel is to terminate neuronal transmission and signal conduction between synapses to prevent ACh diffusion and activation of nearby receptors .

HY-P2860

Acetylcholinesterase, Fly head ACHE; EC 3.1.1.7	Cholinesterase (ChE)	Neurological Disease
Acetylcholinesterase, Fly head (ACHE; EC 3.1.1.7) is a cholinergic enzyme mainly found in neuromuscular junctions and cholinergic type chemical synapses used in biochemical research. Acetylcholinesterase, Fly head catalyzes the breakdown or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetate and choline. Acetylcholinesterase, Fly head's main role is to terminate neuronal transmission and signaling between synapses to prevent ACh spread and activation of nearby receptors .

HY-N0491

(-)-Sparteine sulfate (-)-Lupinidine sulfate	nAChR	Neurological Disease
(-)-Sparteine (sulfate) is a quinolizidine alkaloid that can be extracted from Lupinus. (-)-Sparteine (sulfate) inhibits the release of *acetylcholine* and has anticonvulsant effects .

HY-101010

Methylfurmethide iodide	Others	Neurological Disease
Methylfurmethide is an acetylcholine receptor. Methylfurmethide blocks the uptake of atropine. Methylfurmethide can be used to study the properties of acetylcholine receptors in intestinal smooth muscle .

HY-14334

SAM-315 WAY-255315	5-HT Receptor	Neurological Disease
SAM-315 (WAY-255315) is a potent antagonist of 5-Hydroxytryptamine-6, with K_i and IC₅₀ of 1.1 nM and 4.6 nM, respectively. SAM-315 significantly increases acetylcholine and glutamate release in hippocampus of the brain .

HY-B2152

Hemicholinium 3 Hemicholinium dibromide	Cholinesterase (ChE)	Neurological Disease
Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a K_i value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh) . Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [ ³H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively .

HY-14223

SM-21	Drug Derivative	Neurological Disease
SM-21 is a derivative of R-(+)-hyoscyamine with potent antinociceptive and cognitive enhancing activities. SM-21 works by affecting the release of acetylcholine .

HY-B1552B

Benzoquinonium dibromide	nAChR	Neurological Disease
Benzoquinonium dibromide is a *nicotinic acetylcholine* receptors (nAChRs) antagonist, with an IC₅₀** of 0.46 μM. Benzoquinonium dibromide can block neuromuscular and ganglionic transmission .

HY-132409S

Monocrotophos-d6	Isotope-Labeled Compounds Cholinesterase (ChE)	Infection Neurological Disease
Monocrotophos-d₆ is the deuterium labeled Monocrotophos. Monocrotophos. Monocrotophos is an organophosphate insecticide with broad application in crops. Monocrotophos inhibits the activity of the acetylcholine esterase (AChE) enzyme and affects the neurotransmission between neurons[1].

HY-136146

SUVN-911	nAChR	Neurological Disease
SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a K_i of 1.5 nM. SUVN-911 has antidepressant activity .

HY-A0215

Doxacurium chloride BW-A 938U; Nuromax	nAChR	Neurological Disease
Doxacurium chloride (BW A938U) is a potent non-depolarizing neuromuscular blocking agent. Doxacurium chloride binds to cholinergic receptors to antagonize acetylcholine, resulting in a block of neuromuscular transmission. Doxacurium chloride can be used for the research of neurological diseases .

HY-107682

TQS	nAChR	Neurological Disease Inflammation/Immunology
TQS is a α7 nicotinic acetylcholine receptor (nAChR) positive allosteric modulator. TQS can be used for the research of neuroinflammatory pain .

HY-111051

JN403	nAChR	Neurological Disease
JN403 is an orally active and selective *α7 nicotinic acetylcholine* receptor** agonist. JN403 can be used in the study of central nervous system disorders .

HY-B1813A

(±)-Vesamicol hydrochloride (±)-AH5183 hydrochloride	Sigma Receptor	Neurological Disease
(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent *vesicular acetylcholine* transport inhibitor with a K_i of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with K_i**s of 26 nM and 34 nM, respectively .

HY-101372A

Oxotremorine M iodide	mAChR	Neurological Disease
Oxotremorine M iodide is a potent and non-selective *muscarinic acetylcholine* receptor (mAChR)** agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms .

HY-N4080

Cyclobuxine D	mAChR	Inflammation/Immunology
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on *acetylcholine* and Ba ⁺⁺−induced contraction of the longitudinal muscle isolated from the rabbit jejunum .

HY-119226

VU0152099	mAChR	Neurological Disease
VU0152099 is a potent, selective and brain-penetrant mAChR M4 positive allosteric modulator with an EC₅₀ of 0.4 µM for rat M4 receptor. VU0152099 is inactive for other mAChR subtypes or other GPCRs. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine .

HY-113995

(-)-Vesamicol AH5183	mAChR	Neurological Disease
(-)-Vesamicol (AH5183) is an inhibitor of *acetylcholine* transport into synaptic vesicles, with the IC₅₀ of 75 nM . (-)-Vesamicol can be used for release and recycling of synaptic vesicles study .

HY-128783

VU0090157	mAChR	Neurological Disease
VU0090157 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR). VU0090157 increases the affinity of ACh by binding to the allosteric site. VU0090157 can be used in the study of schizophrenia and Alzheimer's disease .

HY-121141

Adiphenine	nAChR	Neurological Disease
Adiphenine is a non-competitive inhibitor of *nicotinic acetylcholine* receptor (nAChR), with an IC₅₀s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4**, respectively. Adiphenine has anticonvulsant effects .

HY-B0379A

Adiphenine hydrochloride 1 Publications Verification	nAChR	Neurological Disease
Adiphenine hydrochloride is a non-competitive inhibitor of *nicotinic acetylcholine* receptor (nAChR), with an IC₅₀s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4**, respectively. Adiphenine hydrochloride has anticonvulsant effects .

HY-B0321

Tropicamide 4 Publications Verification Ro 1-7683	mAChR	Neurological Disease
Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. When used as an eye drop, Tropicamide causes short-term mydriasis (pupil dilation) and cycloplegia. Tropicamide can be used in the research of neurological diseases, such as epilepsy .

HY-19752A

VU0357017 hydrochloride CID-25010775	mAChR	Neurological Disease
VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of *M₁ muscarinic acetylcholine* receptor, with an EC₅₀** of 477 nM. VU0357017 hydrochloride is highly selective for M₁ and has no activity at M₂-M₅ up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia .

HY-100234A

DREADD agonist 21 dihydrochloride 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 dihydrochloride is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

HY-100234

DREADD agonist 21 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

HY-19651B

Zanapezil fumarate TAK-147 fumarate	Cholinesterase (ChE)	Neurological Disease
Zanapezil (TAK-147) fumarate is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil fumarate shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC₅₀=51.2 nM). Zanapezil fumarate shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K_i values of 234 and 340 nM, respectively. Zanapezil fumarate can be used for the research of early stages of Alzheimer's disease (AD) .

HY-19651A

Zanapezil TAK-147	Cholinesterase (ChE)	Neurological Disease
Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC₅₀=51.2 nM). Zanapezil shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K_i values of 234 and 340 nM, respectively. Zanapezil can be used for the research of early stages of Alzheimer's disease (AD) .

HY-B0379AR

Adiphenine (hydrochloride) (Standard)	nAChR	Neurological Disease
Adiphenine (hydrochloride) (Standard) is the analytical standard of Adiphenine (hydrochloride). This product is intended for research and analytical applications. Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine hydrochloride has anticonvulsant effects .

HY-162897

BAY-2413555	mAChR	Cardiovascular Disease
BAY-2413555 is an orally active *muscarinic acetylcholine* receptor M2** modulator that protects the heart and improve cardiac function. BAY-2413555 is promising for research of heart failure .

HY-19651

Zanapezil free base TAK-147 free base	Cholinesterase (ChE)	Neurological Disease
Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC₅₀=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with K_i values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD) .

HY-14824A

Sofinicline benzenesulfonate ABT 894 benzenesulfonate	nAChR	Neurological Disease
Sofinicline benzenesulfonate (ABT 894 benzenesulfonate) is a novel nicotinic acetylcholine receptor agonist, specifically acting on the α4β2 subtype of nAChR (IC₅₀=0.1 nM). Sofinicline benzenesulfonate has the potential to improve cognitive function, including attention, memory and working memory. Sofinicline benzenesulfonate can be used in studies of attention deficit, hyperactivity disorder (ADHD) .

HY-B0489A

Arecoline hydrochloride	mAChR nAChR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Arecoline hydrochloride, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and *muscarinic acetylcholine* receptor**. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress .

HY-N2364

Arecoline 2 Publications Verification	mAChR nAChR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and *muscarinic acetylcholine* receptor**. Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress .

HY-12560A

PNU-282987 10+ Cited Publications	nAChR 5-HT Receptor	Neurological Disease
PNU-282987 is a potent *α7 nicotinic acetylcholine* receptor (nAChR) agonist with an EC₅₀ of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT₃ receptor with an IC₅₀** of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems .

HY-19742A

Lecozotan hydrochloride SRA-333 hydrochloride	5-HT Receptor	Neurological Disease
Lecozotan (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT_1A with a K_i of 4.5 nM for cloned human 5-HT_1A receptor. Lecozotan hydrochloride enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan hydrochloride has the potential for mild-to-moderate Alzheimer's disease (AD) research .

HY-117483

Gly-Pro-Glu	iGluR	Neurological Disease
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC₅₀ value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .

HY-B0489

Arecoline hydrobromide 2 Publications Verification methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide	mAChR nAChR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and *muscarinic acetylcholine* receptor**. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress .

HY-12560

PNU-282987 free base	nAChR 5-HT Receptor	Neurological Disease
PNU-282987 (free base) is a potent *α7 nicotinic acetylcholine* receptor (nAChR) agonist with an EC₅₀ of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT₃ receptor with an IC₅₀** of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems .

HY-110160

Pozanicline dihydrochloride ABT-089 dihydrochloride	nAChR	Neurological Disease
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a K_i of 16.7 nM for binding to [ ³H]cytisine sites . Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a K_i of 17 nM while binding to α7 nAChR is insignificant .

Cat. No.	Product Name	Type

HY-B0282A

Acetylcholine bromide

10+ Cited Publications

ACh bromide

Biochemical Assay Reagents

Acetylcholine bromide is an organic choline salt compound commonly used in neurophysiology and pharmacology experiments. It plays an important role in the nervous system, acting as a neurotransmitter that transmits signals and regulates many important physiological functions. Due to its special biological activity, Acetylcholine bromide is widely used in the study of neurotransmitters, nerve damage and muscle movement.

HY-N2338

Cholesterol myristate Cholesteryl myristate; Cholesteryl tetradecanoate	Drug Delivery
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the *nicotinic acetylcholine* receptor, GABAA receptor, and the inward-rectifier potassium ion channel**.

HY-W127702

Scopolamine nitrate Methscopolamine nitrate	Biochemical Assay Reagents
Scopolamine (nitrate) is an organic compound commonly used in neuroscience research and pharmacology research. It can be used to study the role and structure of acetylcholine receptors, and is widely used in drug development and research in related fields. In addition, this compound is also used as a substrate or catalyst in certain biochemical reactions.

HY-134952

Acetylcholine perchlorate	Cell Assay Reagents
Acetylcholine perchlorate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W127670

Decamethonium iodide

Cell Assay Reagents

Decamethonium (iodide) is an organic compound containing ammonium and iodide ions. It is commonly used as a neuromuscular blocking agent in anesthesia to induce muscle relaxation during surgery. Decamethonium Iodide acts by binding to nicotinic acetylcholine receptors (nAChRs) in the neuromuscular junction, causing depolarization block and subsequent skeletal muscle paralysis. In addition, it can also serve as a reference standard for pharmacological studies of nAChRs.

HY-B1661

Hexamethonium chloride

Hexone chloride

Biochemical Assay Reagents

Hexamethonium Chloride Dihydrate is a synthetic organic compound commonly used as a ganglion blocking agent, which means it blocks the transmission of nerve impulses between ganglion cells in the autonomic nervous system. Hexamethonium Chloride Dihydrate is used in various medical applications such as lowering blood pressure or inhibiting certain types of neuropathic pain. It works by inhibiting the release of acetylcholine, a neurotransmitter that plays a key role in regulating many bodily functions.

HY-W127641R

β-Methylcholine chloride (Standard)

Biochemical Assay Reagents

β-Methylcholine (chloride) (Standard) is the analytical standard of β-Methylcholine (chloride). This product is intended for research and analytical applications. β-Methylcholine chloride is an organic compound containing choline and chloride ions. It is commonly used as a pharmacological research tool, especially in the study of acetylcholine receptors and signaling pathways. β-Methylcholine chloride has various applications in the pharmaceutical industry, especially as a standard reference material for the calibration of analytical instruments. In addition, it can be used in the production of other choline derivatives and as a precursor of neurotransmitters.

Cat. No.	Product Name	Target	Research Area

HY-117483

Gly-Pro-Glu	iGluR	Neurological Disease
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC₅₀ value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .

HY-P1271

Catestatin Catestatin (cattle)	nAChR	Cardiovascular Disease
Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin is an endogenous peptide that regulates cardiac function and blood pressure . Catestatin is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release .

HY-P1271A

Catestatin TFA	nAChR	Cardiovascular Disease
Catestatin TFA is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin TFA is an endogenous peptide that regulates cardiac function and blood pressure . Catestatin TFA is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release .

HY-P3960

(Glu2)-TRH	Thyroid Hormone Receptor Endogenous Metabolite	Neurological Disease
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

HY-P5544

M-TriDAP N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a NOD1/2 agoist and biological active peptide .

HY-P1016

BQ-3020	Endothelin Receptor	Cardiovascular Disease
BQ-3020 is a selective endothelin receptor (ET_B receptor) agonist that displaces [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research ¹ ².

HY-P5823

Azemiopsin	nAChR	Neurological Disease
Azemiopsin is a potent nicotinic acetylcholine receptor (nAChR) inhibitor with IC₅₀s of 0.18 μM and 22 μM against T. californica nAChR and human α7 nAChR, respectively. Azemiopsin blocks acetylcholine-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR .

HY-P5544A

M-TriDAP TFA N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid TFA	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) TFA is a NOD1/2 agoist and biological active peptide .

HY-P4129

Rabies Virus Matrix Protein Fragment(RV-MAT)	nAChR	Others
Rabies Virus Matrix Protein Fragment (RV-MAT) is a polypeptide. Rabies Virus Matrix Protein Fragment targets the acetylcholine receptor (AChR) that exists on the cell surface .

HY-P1264F1

Biotin-α-Bungarotoxin	nAChR	Neurological Disease
Biotin-α-Bungarotoxin is the Biotin labelled α-Bungarotoxin (HY-P1264). α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs) .

HY-P1264F

α-Bungarotoxin, FITC labeled	nAChR	Neurological Disease
α-Bungarotoxin, FITC labeledis the FITC labelled α-Bungarotoxin (HY-P1264). α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs) .

HY-P5833

κ-Bungarotoxin κ-Bgt	nAChR	Neurological Disease
κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of *α3β2 neuronal nicotinic acetylcholine* receptors with an IC₅₀** of 2.30 nM .

HY-P2087

Bassianolide	Insecticide Parasite Bacterial	Infection
Bassianolide is a cyclooligomer depsipeptide secondary metabolite. Bassianolide is an insecticidal virulence factor of Beauveria bassiana. Bassianolide inhibits acetylcholine-induced smooth muscle contraction, and shows moderate antiplasmodial and anti-mycobacterial activities .

HY-P2161B

TAK-683 acetate 1 Publications Verification	Kisspeptin Receptor	Cancer
TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

HY-P2161A

TAK-683 TFA	Kisspeptin Receptor	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

HY-P2161

TAK-683	Kisspeptin Receptor	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

HY-P1375

[D-Trp7,9,10]-Substance P	nAChR	Endocrinology
[D-Trp7,9,10]-Substance P is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors .

HY-P1375A

[D-Trp7,9,10]-Substance P TFA	mAChR	Endocrinology
[D-Trp7,9,10]-Substance P TFA is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors .

HY-P5798

Fasciculin-I FAS-I	Cholinesterase (ChE)	Neurological Disease
Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting acetylcholinesterase (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes .

HY-P3064

Scyllatoxin Leiurotoxin I	Potassium Channel	Neurological Disease
Scyllatoxin (Leiurotoxin I) is a peptide toxin, it can be isolated from the venom of the scorpion (Leiurus quinquestriatus hebraeus). Scyllatoxin is a blocker of small-conductance K_Ca (SK) channel. Scyllatoxin enhances both norepinephrine (NE) and epinephrine (Epi) release in vivo .

HY-P0033A

Argireline acetate Acetyl hexapeptide-3 acetate	Calcium Channel	Neurological Disease
Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity .

HY-P5623B

RVG TFA RVG29 TFA; RDP TFA; Rabies Virus Glycoprotein-29 TFA	Bacterial	Infection
RVG TFA is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

HY-P0033

Argireline Acetyl hexapeptide-3	Calcium Channel	Neurological Disease
Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity .

HY-P5623

RVG RVG29; RDP; Rabies Virus Glycoprotein-29	Bacterial	Infection
RVG (RVG29) is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

HY-P1264

α-Bungarotoxin 5 Publications Verification	nAChR	Neurological Disease
α-Bungarotoxin is a competitive antagonist at *nicotinic acetylcholine* receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC₅₀** of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM .

HY-P0099

Pentapeptide-3	nAChR	Others
Pentapeptide-3 is a pentapeptide fragment of neurotoxin waglerin-1, it can be extracted from the venom of Temple Viper. Pentapeptide-3 is a competitive antagonist of *nicotinic acetylcholine* receptors (nAChRs)**, it can blocks nerves at the post-synaptic membrane. Pentapeptide-3 has anti-aging effects and it can be used together with other cosmetic peptides .

HY-P0084

Cyclic somatostatin SRIF-14; Somatostatin-14	Endogenous Metabolite	Cardiovascular Disease Neurological Disease
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC₅₀ value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease .

HY-P3071

ShK toxin Stichodactyla helianthus neurotoxin	Potassium Channel	Inflammation/Immunology
ShK toxin blocks voltage-dependent potassium channel (K_v1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .

HY-P0084R

Cyclic somatostatin (Standard)	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Cyclic somatostatin (Standard) is the analytical standard of Cyclic somatostatin. This product is intended for research and analytical applications. Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0282

Acetylcholine chloride 10+ Cited Publications ACh chloride	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	nAChR Calcium Channel Endogenous Metabolite
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-101086

Acetylcholine iodide 10+ Cited Publications ACh iodide	Structural Classification Natural Products Animals Source classification	Endogenous Metabolite mAChR
Acetylcholine iodide is a muscarinic receptor modulator. Acetylcholine iodide specifically binds to muscarinic receptors, inhibits sodium absorption, and induces chloride secretion. Acetylcholine iodide changes intestinal ion transport, enhances intestinal secretory function, induces or maintains mammary gland development and lactation. Acetylcholine iodide can be used for intestinal ion transport regulation and mammary gland physiological function research .

HY-N2364

Arecoline 2 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Areca catechu L. Source classification Metabolic Disease Plants Infection Alkaloids Piperidine Alkaloids Palmae Inflammation/Immunology Disease Research Fields	mAChR nAChR
Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and *muscarinic acetylcholine* receptor**. Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress .

HY-B0489

Arecoline hydrobromide 2 Publications Verification methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide	Structural Classification Neurological Disease Classification of Application Fields Areca catechu L. Source classification Metabolic Disease Plants Infection Alkaloids Other Alkaloids Palmae Inflammation/Immunology Disease Research Fields	mAChR nAChR
Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and *muscarinic acetylcholine* receptor**. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress .

HY-P3960

(Glu2)-TRH	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Thyroid Hormone Receptor Endogenous Metabolite
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

HY-N7004

Arborine	Cardiovascular Disease Alkaloids Glycosmis arborea (Retz.) Corrêa Classification of Application Fields Source classification Rutaceae Plants Disease Research Fields	mAChR
Arborine inhibits the peripheral action of acetylcholine and induces a fall in blood pressure .

HY-B0282R

Acetylcholine chloride (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	nAChR Calcium Channel Endogenous Metabolite
Acetylcholine (chloride) (Standard) is the analytical standard of Acetylcholine (chloride). This product is intended for research and analytical applications. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-N4080

Cyclobuxine D	other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Steroids	mAChR
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on *acetylcholine* and Ba ⁺⁺−induced contraction of the longitudinal muscle isolated from the rabbit jejunum .

HY-B0489A

Arecoline hydrochloride	Structural Classification Neurological Disease Classification of Application Fields Areca catechu L. Source classification Metabolic Disease Plants Infection Alkaloids Other Alkaloids Palmae Inflammation/Immunology Disease Research Fields	mAChR nAChR
Arecoline hydrochloride, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and *muscarinic acetylcholine* receptor**. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress .

HY-B0489R

Arecoline (hydrobromide) (Standard)	Alkaloids Structural Classification Areca catechu L. Other Alkaloids Source classification Palmae Plants	mAChR nAChR
Arecoline (hydrobromide) (Standard) is the analytical standard of Arecoline (hydrobromide). This product is intended for research and analytical applications. Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress .

HY-N0443

N-Methylcytisine 1 Publications Verification Caulophylline	Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Source classification Pyridine Alkaloids Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology	nAChR
N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (K_d = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia .

HY-N0340

Scopolamine butylbromide 1 Publications Verification Hyoscine butylbromide; (-)-Scopolamine butylbromide; Butylscopolamine bromide	Alkaloids Structural Classification Other Alkaloids Source classification Datura metel L. Solanaceae Plants	mAChR
Scopolamine butylbromide is a competitive antagonist of muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM.

HY-W983015

Davidigenin	Structural Classification Euphorbia portlandica L. Source classification Phenols Polyphenols Euphorbiaceae Plants	5-HT Receptor
Davidigenin is an antidiabetic compound with antitumor, antispasmodic, and antioxidant activities. Davidigenin inhibits duodenal contractions induced by acetylcholine or histamine.

HY-B0726

Pilocarpine Hydrochloride Maximum Cited Publications 30 Publications Verification	Alkaloids Structural Classification other families Other Alkaloids Source classification Plants	mAChR
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-N15414

Demethoxykanugin Desmethoxykanugin	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Derris indica	Cholinesterase (ChE)
Demethoxykanugin (Desmethoxykanugin, compound 1) is a acetylcholine (AChE) inhibitor. Demethoxykanugin shows cell cytotoxicity agains Vero cells .

HY-B1006

Pilocarpine nitrate Maximum Cited Publications 30 Publications Verification	Alkaloids Structural Classification other families Other Alkaloids Source classification Plants	mAChR
Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-N3610

Coclaurine 1 Publications Verification	Alkaloids Structural Classification Source classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.	nAChR
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. Coclaurine is a *nicotinic acetylcholine* receptor (nAChRs)** antagonist .

HY-W795027

Anatoxin-a ATX-a	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	nAChR Cholinesterase (ChE)
Anatoxin-a (ATX-a) is a neurotoxic alkaloid. Anatoxin-a acts as both a *nicotinic acetylcholine* receptor (nAChR) agonist and an Acetylcholinesterase (AChE)** inhibitor .

HY-N0443R

N-Methylcytisine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Leguminosae Source classification Pyridine Alkaloids Sophora flavescens Aiton Plants	nAChR
N-Methylcytisine (Standard) is the analytical standard of N-Methylcytisine. This product is intended for research and analytical applications. N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia .

HY-W705106

(-)-Coclaurine hydrochloride (-)-(S)-Coclaurine hydrochloride; (S)-Coclaurine hydrochloride; l-Coclaurine hydrochloride	Structural Classification Alkaloids Piperidine Alkaloids Source classification Cocculus laurifolius DC. Plants Menispermaceae	nAChR
(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a *nicotinic acetylcholine* receptor (nAChRs)** antagonist .

HY-N0435

Isorhamnetin 3-gentiobioside	Flavonols Flavonoids Classification of Application Fields Neurological Disease Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Astragalus altaicus Bunge	Others
Isorhamnetin 3-gentiobioside protects the morphological structures and restores acetylcholine level in rat hippocampus, and improves brain functions via normalizing brain EEG .

HY-131574

Heliosupine N-oxide	Alkaloids Pyrrole Alkaloids Source classification Cynoglossumofficinale Linn. Plants Boraginaceae	mAChR
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

HY-100196AR

Pyrroloquinoline quinone (disodium salt) (Standard)	Quinones Structural Classification Microorganisms Source classification Benzene Quinones Endogenous metabolite	Endogenous Metabolite
Triazophos (Standard) is the analytical standard of Triazophos. This product is intended for research and analytical applications. Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.

HY-N2338

Cholesterol myristate Cholesteryl myristate; Cholesteryl tetradecanoate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	nAChR GABA Receptor Potassium Channel Endogenous Metabolite
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the *nicotinic acetylcholine* receptor, GABAA receptor, and the inward-rectifier potassium ion channel**.

HY-N9949

Sparteine Lupinidine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Fabaceae Lupinus sulphureus Douglas	nAChR
Sparteine (Lupinidine) is an alkaloid compound derived from leguminous plants and can act as a ganglionic blocker. Sparteine competitively inhibits the activity of the neuronal nicotinic acetylcholine receptor (nACh receptor) .

HY-P2087

Bassianolide	Structural Classification Microorganisms Cyclopeptides Source classification	Insecticide Parasite Bacterial
Bassianolide is a cyclooligomer depsipeptide secondary metabolite. Bassianolide is an insecticidal virulence factor of Beauveria bassiana. Bassianolide inhibits acetylcholine-induced smooth muscle contraction, and shows moderate antiplasmodial and anti-mycobacterial activities .

HY-B0726R

Pilocarpine Hydrochloride (Standard)	Alkaloids Structural Classification other families Other Alkaloids Source classification Plants	mAChR
Pilocarpine (Hydrochloride) (Standard) is the analytical standard of Pilocarpine (Hydrochloride). This product is intended for research and analytical applications. Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-100806

Kynurenic acid 4 Publications Verification Quinurenic acid	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Quinoline Alkaloids Endogenous metabolite Disease Research Fields Endocrinology	iGluR Endogenous Metabolite Apoptosis CXCR GPR35
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting *NMDA, glutamate, α7 nicotinic acetylcholine* receptor. Kynurenic acid is also an agonist of GPR35/CXCR8**.

HY-107512

Kynurenic acid sodium 4 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields	iGluR Apoptosis Endogenous Metabolite CXCR GPR35
Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting *NMDA, glutamate, α7 nicotinic acetylcholine* receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8**.

HY-B1006R

Pilocarpine nitrate (Standard)	Alkaloids Structural Classification other families Other Alkaloids Source classification Plants	mAChR
Pilocarpine (nitrate) (Standard) is the analytical standard of Pilocarpine (nitrate). This product is intended for research and analytical applications. Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-101036

Choline bitartrate 2 Publications Verification	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	mAChR Endogenous Metabolite
Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders . Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism .

HY-N7690

3,5,7,3′,4′-Pentamethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Metabolic Disease Plants Disease Research Fields Zingiberaceae	Calcium Channel
3,5,7,3’,4’-Pentamethoxyflavone is a Ca ²⁺ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases .

HY-N1064

Xanthoplanine	Alkaloids Structural Classification Monophenols other families Source classification Phenols Plants Isoquinoline Alkaloids	nAChR
Xanthoplanine, isolated from theroot of Xylopia parviflora, fully inhibits the EC₅₀ ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC₅₀ values of 9 μM (alpha7) and 5 μM (alpha4beta2) .

HY-121027

Anagyrine (-)-Anagyrine; Monolupine; Rhombinine	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Plants Disease Research Fields Lupinus albus Linn. Cancer	mAChR nAChR
Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to *muscarinic and nicotinic acetylcholine* receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR**, and Anagyrine can directly, without metabolism, desensitize nAChR .

HY-121027A

Anagyrine hydrochloride (-)-Anagyrine hydrochloride; Monolupine hydrochloride; Rhombinine hydrochloride	Structural Classification Alkaloids Piperidine Alkaloids Leguminosae Source classification Plants Sophora flavescens Aiton	mAChR nAChR
Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to *muscarinic and nicotinic acetylcholine* receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR**, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR .

HY-100806R

Kynurenic acid (Standard) 4 Publications Verification Quinurenic acid (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Quinoline Alkaloids Endogenous metabolite	iGluR Endogenous Metabolite Apoptosis CXCR GPR35
Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting *NMDA, glutamate, α7 nicotinic acetylcholine* receptor. Kynurenic acid is also an agonist of GPR35/CXCR8**.

HY-138800

Spinosad 3 Publications Verification	Structural Classification Natural Products Microorganisms Neurological Disease Classification of Application Fields Source classification Disease Research Fields Biological Pesticide Research Agricultural Research	nAChR
Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity .

HY-114791

Lobelanidine	Structural Classification Alkaloids Lobelia tupa L. Other Alkaloids Source classification Campanulaceae Plants	nAChR
Lobelanidine is an antagonist for nicotinic acetylcholine receptor (nAChR), which inhibits α7 nAChR response and α3β2/α3β4 nAChR responses, with IC₅₀ of 2.8 and 8.2 μM .

HY-B1532

Anabasine (S)-Anabasine; (+)-Anabasine	Alkaloids Piperidine Alkaloids Structural Classification Nicotiana tabacum L. Source classification Pyridine Alkaloids Solanaceae Plants	nAChR
Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical?pesticide?nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 μM) .

HY-101036R

Choline (bitartrate) (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	mAChR Endogenous Metabolite
Choline (bitartrate) (Standard) is the analytical standard of Choline (bitartrate). This product is intended for research and analytical applications. Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders . Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism .

HY-138800R

Spinosad (Standard)	Structural Classification Natural Products Microorganisms Source classification	nAChR
Spinosad (Standard) is the analytical standard of Spinosad. This product is intended for research and analytical applications. Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity .

HY-B1532R

Anabasine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Nicotiana tabacum L. Source classification Pyridine Alkaloids Solanaceae Plants	nAChR
Anabasine (Standard) is the analytical standard of Anabasine. This product is intended for research and analytical applications. Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 μM) .

HY-N0801

Polygalacic acid	Triterpenes Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	MMP Cholinesterase (ChE)
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex .

HY-B0394R

Atropine sulfate monohydrate (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (sulfate monohydrate) (Standard) is the analytical standard of Atropine (sulfate monohydrate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-B1205AR

Atropine sulfate (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-W009592R

Glycyl-L-tyrosine (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms Ketones, Aldehydes, Acids Solanum tuberosum Linn. Source classification Phenols Solanaceae Plants Endogenous metabolite	Others
Cyclic somatostatin (Standard) is the analytical standard of Cyclic somatostatin. This product is intended for research and analytical applications. Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease .

HY-N0584AR

Anisodamine hydrobromide (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Anisodus tanguticus (Maxinowicz) Pascher Source classification Solanaceae Plants	mAChR
Anisodamine (hydrobromide) (Standard) is the analytical standard of Anisodamine (hydrobromide). This product is intended for research and analytical applications. Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties .

HY-N0584

Anisodamine 6-Hydroxyhyoscyamine	Alkaloids Structural Classification Neurological Disease Classification of Application Fields Other Alkaloids Anisodus tanguticus (Maxinowicz) Pascher Source classification Solanaceae Plants Disease Research Fields	mAChR
Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning .

HY-N0584A

Anisodamine hydrobromide 6-Hydroxyhyoscyamine hydrobromide	Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Anisodus tanguticus (Maxinowicz) Pascher Source classification Solanaceae Plants Inflammation/Immunology Disease Research Fields	mAChR
Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties .

HY-B1178

Cotinine 1 Publications Verification (-)-Cotinine; (S)-Cotinine; NIH-10498	Alkaloids Structural Classification Pyrrole Alkaloids Nicotiana tabacum L. Classification of Application Fields Source classification Other Diseases Pyridine Alkaloids Solanaceae Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite nAChR
Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .

Species:	Human (10) Mouse (2) Rat (1)
Tag:	His (12) SUMO (3) Trx (1) Flag (3)
Source:	HEK293 (4) Sf9 insect cells (1) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P72141

	CHRNA1 Protein, Mouse (His) Chrna1; Acra; acetylcholine receptor subunit alpha	Mouse	E. coli
	The CHRNA1 protein, also known as the acetylcholine receptor (AChR), undergoes significant conformational changes upon binding of acetylcholine. This change affects all subunits, causing the opening of ion-conducting channels across the plasma membrane. CHRNA1 Protein, Mouse (His) is the recombinant mouse-derived CHRNA1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CHRNA1 Protein, Mouse (His) is 210 a.a., with molecular weight of ~25 kDa.

HY-P70340

	nAChRα5 Protein, Human (HEK293, His) rHuNeuronal acetylcholine receptor subunit alpha-5/NACHRA5, His; Neuronal acetylcholine Receptor Subunit Alpha-5; CHRNA5; NACHRA5	Human	HEK293
	The nAChRα5 protein induces significant conformational changes in all subunits upon acetylcholine binding, leading to the opening of ion-conducting channels in the plasma membrane. nAChRα5, composed of α and non-α (β) subunits, interacts with LYPD6 to reveal complex regulatory mechanisms in neuronal acetylcholine receptors. nAChRα5 Protein, Human (HEK293, His) is the recombinant human-derived nAChRα5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of nAChRα5 Protein, Human (HEK293, His) is 232 a.a., with molecular weight of 35-40 kDa.

HY-P72143

	CHRNA1 Protein, Tetronarce californica (His-SUMO) CHRNA1acetylcholine receptor subunit alpha	Others	E. coli
	The CHRNA1 Protein, recognized as the acetylcholine receptor (AChR), undergoes a crucial conformational shift upon acetylcholine binding. This alteration affects all subunits, activating an ion-conducting channel across the plasma membrane. The pentameric structure includes two alpha chains, in addition to one each of the beta, delta, and gamma chains. CHRNA1 Protein, Tetronarce californica (His-SUMO) is the recombinant CHRNA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CHRNA1 Protein, Tetronarce californica (His-SUMO) is 210 a.a., with molecular weight of ~40.8 kDa.

HY-P704033

	CHRNA7 Protein, Human (His) Neuronal acetylcholine receptor subunit alpha-7; CHRNA7; NACHRA7	Human	E. coli

HY-P70056

	CHRNB3 Protein, Human (HEK293, His) rHuNeuronal acetylcholine receptor subunit beta-3/CHRNB3, His ; Neuronal acetylcholine receptor subunit beta-3	Human	HEK293
	CHRNB3 Protein, a vital constituent of the acetylcholine receptor (AChR), induces a significant conformational shift upon acetylcholine binding. This change affects all subunits, leading to the activation of an ion-conducting channel across the plasma membrane. The neuronal AChR complex comprises alpha and beta subunits, emphasizing their intricate collaboration in responding to acetylcholine stimulation. CHRNB3 Protein, Human (HEK293, His) is the recombinant human-derived CHRNB3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CHRNB3 Protein, Human (HEK293, His) is 208 a.a., with molecular weight of 30-40 kDa.

HY-P72142

	CHRNA1 Protein, Mouse (His-SUMO) Chrna1; Acra; acetylcholine receptor subunit alpha	Mouse	E. coli
	The CHRNA1 protein, also known as the acetylcholine receptor (AChR), undergoes significant conformational changes upon binding of acetylcholine. This change affects all subunits, causing the opening of ion-conducting channels across the plasma membrane. CHRNA1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived CHRNA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CHRNA1 Protein, Mouse (His-SUMO) is 210 a.a., with molecular weight of ~40.5 kDa.

HY-P72138

	CHRM1 Protein, Rat (His) Chrm1; Chrm-1Muscarinic acetylcholine receptor M1	Rat	E. coli
	CHRM1, the muscarinic acetylcholine receptor, mediates cellular responses, including adenylate cyclase inhibition, phosphoinositide breakdown, and potassium channel modulation through G protein actions.It engages with GPRASP2 and TMEM147, contributing to a complex network of signaling pathways and cellular processes regulated by the receptor.CHRM1 Protein, Rat (His) is the recombinant rat-derived CHRM1 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P72144

	CHRNA3 Protein, Human (His-SUMO) ACHA3_HUMAN; AChR; Cholinergic receptor neuronal nicotinic alpha polypeptide 3; Cholinergic receptor nicotinic alpha 3; Cholinergic receptor nicotinic alpha polypeptide 3; CHRNA 3; CHRNA3; LNCR2; MGC104879; NACHRA 3; NACHRA3; Neuronal acetylcholine receptor protein alpha 3 chain precursor; Neuronal acetylcholine receptor subunit alpha 3; Neuronal acetylcholine receptor subunit alpha-3; Neuronal nicotinic acetylcholine receptor alpha 3 subunit; PAOD2	Human	E. coli
	CHRNA3 Protein, a critical contributor to collagen fibrillogenesis, regulates the rate of fibril formation and influences the assembly and organization of collagen fibrils. Binding to both type I and type II collagen, CHRNA3 plays a pivotal role in shaping the structural integrity of the extracellular matrix. CHRNA3 Protein, Human (His-SUMO) is the recombinant human-derived CHRNA3 protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag. The total length of CHRNA3 Protein, Human (His-SUMO) is 209 a.a., with molecular weight of ~44.6 kDa.

HY-P704012

	CHRM2 Protein, Human (His) Muscarinic acetylcholine receptor M2; CHRM2; Homo sapiens; Human; G-protein coupled receptor; Receptor; Transducer	Human	E. coli
	CHRM2 Protein, Human (His) is the recombinant human-derived CHRM2, expressed by E. coli , with N-6*His labeled tag.

HY-P703102

	M1R Protein, Human (HEK293, Flag) Muscarinic acetylcholine receptor M1; CHRM1; Homo sapiens; Human; G-protein coupled receptor; Receptor; Transducer	Human	HEK293
	M1R Protein, Human (HEK293, Flag) is the recombinant human-derived M1R, expressed by HEK293 , with Flag labeled tag. ,

HY-P703103

	CHRM2 Protein, Human (Sf9, Flag, His) Muscarinic acetylcholine receptor M2; CHRM2; Homo sapiens; Human; G-protein coupled receptor; Receptor; Transducer	Human	Sf9 insect cells
	CHRM2 Protein, Human (Sf9, Flag, His) is the recombinant human-derived CHRM2, expressed by Sf9 insect cells , with His, Flag labeled tag.

HY-P703104

	M2R Protein, Human (HEK293, Flag) Muscarinic acetylcholine receptor M2; CHRM2; Homo sapiens; Human; G-protein coupled receptor; Receptor; Transducer	Human	HEK293
	M2R Protein, Human (HEK293, Flag) is the recombinant human-derived M2R, expressed by HEK293 , with Flag labeled tag. ,

HY-P72139

	CHRNA1 Protein, Human (His) acetylcholine receptor subunit alpha; ACHA_HUMAN; AChR; ACHRA; ACHRD; CHNRA; Cholinergic receptor nicotinic alpha 1 subunit; Cholinergic receptor nicotinic alpha polypeptide 1; Cholinergic receptor; nicotinic; alpha polypeptide 1 muscle; ; Chrna1; CMS1A; CMS1B; CMS2A; FCCMS; Nicotinic cholinergic receptor alpha 1; SCCMS; Schizophrenia neurophysiologic defect candidate	Human	E. coli
	The CHRNA1 Protein undergoes a substantial conformational shift upon acetylcholine binding, influencing all subunits and leading to the activation of an ion-conducting channel. Yet, the acetylcholine receptor alpha subunit of CHRNA1 can be non-functional in certain cases, underscoring the need to comprehend the factors governing its functionality and integration into fully operational acetylcholine-gated cation-selective channels. CHRNA1 Protein, Human (His) is the recombinant human-derived CHRNA1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CHRNA1 Protein, Human (His) is 235 a.a., with molecular weight of ~31.1 kDa.

HY-P72140

	CHRNA1 Protein, Human (His-Trx) acetylcholine receptor subunit alpha; ACHA_HUMAN; AChR; ACHRA; ACHRD; CHNRA; Cholinergic receptor nicotinic alpha 1 subunit; Cholinergic receptor nicotinic alpha polypeptide 1; Cholinergic receptor; nicotinic; alpha polypeptide 1 muscle; ; Chrna1; CMS1A; CMS1B; CMS2A; FCCMS; Nicotinic cholinergic receptor alpha 1; SCCMS; Schizophrenia neurophysiologic defect candidate	Human	E. coli
	The CHRNA1 Protein undergoes a substantial conformational shift upon acetylcholine binding, influencing all subunits and leading to the activation of an ion-conducting channel. Yet, the acetylcholine receptor alpha subunit of CHRNA1 can be non-functional in certain cases, underscoring the need to comprehend the factors governing its functionality and integration into fully operational acetylcholine-gated cation-selective channels. CHRNA1 Protein, Human (His-Trx) is the recombinant human-derived CHRNA1 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of CHRNA1 Protein, Human (His-Trx) is 235 a.a., with molecular weight of ~44.1 kDa.

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Source
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Cat. No.	Product Name	Chemical Structure

HY-B0282S1

Acetylcholine-d9 chloride

Acetylcholine-d₉ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-B0282S

Acetylcholine-d4 chloride

Acetylcholine-d₄ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-B0282AS

Acetylcholine-d9 bromide
Acetylcholine-d₉ (bromide) is the deuterium labeled Acetylcholine bromide .

HY-B0282AS1

Acetylcholine-d4 bromide
Acetylcholine-d₄ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-B0282AS2

Acetylcholine-d13 bromide
Acetylcholine-d₁₃ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-B0282AS3

Acetylcholine-d16 bromide
Acetylcholine-d₁₆ (bromide) is the deuterium labeled Acetylcholine bromide[1].

HY-132409S

Monocrotophos-d6
Monocrotophos-d₆ is the deuterium labeled Monocrotophos. Monocrotophos. Monocrotophos is an organophosphate insecticide with broad application in crops. Monocrotophos inhibits the activity of the acetylcholine esterase (AChE) enzyme and affects the neurotransmission between neurons[1].

HY-17360S

Tiotropium-d3 bromide
Tiotropium-d₃ (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-17360S1

Tiotropium-d6 bromide
Tiotropium-d₆ (bromide) is deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-32067AS

Aceclidine-d3 hydrochloride
Aceclidine-d₃ hydrochloride is a deuterated version of Aceclidine (HY-32067). Aceclidine is a modulator of the M3 muscarinic acetylcholine receptor.

HY-B0726S

Pilocarpine-d3 hydrochloride
Pilocarpine-d₃ (hydrochloride) is deuterium labeled Pilocarpine (Hydrochloride). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-14774S

(Rac)-Monepantel-d5
(Rac)-Monepantel-d₅ is deuterium labeled Monepantel. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.

HY-14774S1

(Rac)-Monepantel sulfone-d5
(Rac)-Monepantel sulfone-d₅ is deuterium labeled Monepantel. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.

HY-B0882S

Edrophonium-d5 chloride
Edrophonium-d₅ (chloride) is the deuterium labeled Edrophonium chloride. Edrophonium chloride is a readily reversible acetylcholinesterase inhibitor; prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.

HY-B0394S

Atropine-d5
Atropine-d₅ is the deuterium labeled Atropine (sulfate monohydrate). Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect[1].

HY-B0942S

Benzethonium-d7 chloride
Benzethonium-d7 chloride is the deuterium labeled Benzethonium chloride. Benzethonium chloride inhibit human recombinant α7 and α4β2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes.

HY-B0726S1

Pilocarpine-d5 hydrochloride
Pilocarpine-d₅ hydrochloride is deuterated labeled Pilocarpine hydrochloride (HY-B0726). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B0827S

Dinotefuran-d3
Dinotefuran-d₃ is the deuterium labeled Dinotefuran[1]. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors[2].

HY-B0106AS

Etiracetam-d3
Etiracetam-d₃ is the deuterium labeled Etiracetam. Etiracetam (UCB 6474) is an acetylcholine agonist and a nootropic drug of the racetam family. Less active than its S-enantiomer Levetiracetam (UCB L059)[1].

HY-107654S

Muscarine-d9 iodide
Muscarine-d₉ (iodide) is the deuterium labeled Muscarine iodide. Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist[1][2].

HY-B0321S

Tropicamide-d3
Tropicamide-d₃ is the deuterium labeled Tropicamide[1]. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops[2][3].

HY-100806S

Kynurenic acid-d5
Kynurenic acid-d₅ is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting *NMDA, glutamate, α7 nicotinic acetylcholine* receptor. Kynurenic acid is also an agonist of GPR35/CXCR8 .**

HY-106901AS

Asoxime-d4 dichloride
Asoxime-d₄ (dichloride) is the deuterium labeled Asoxime dichloride. Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system[1].

HY-13204AS

Biperiden-d5
Biperiden-d₅ (KL 373-d₅) is deuterium labeled Biperiden. Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting *acetylcholine* and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders .

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-10019S

Varenicline-d4

Varenicline-d₄ is deuterium labeled Varenicline. Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively[1]. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment[2].

HY-10019AS1

Varenicline-d4 hydrochloride

Varenicline-d₄ hydrochloride is a deuterium labeled Varenicline (dihydrochloride) (HY-10019A) . Varenicline (CP 526555) dihydrochloride is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC₅₀ value of 2.3 μM. Varenicline dihydrochloride is a full agonist for α3β4 and α7 nAChRs with EC₅₀ values of 55 μM and 18 μM, respectively . Varenicline dihydrochloride is a nicotinic ligand based on the structure of cytosine, and has the potential for smoking cessation treatment .

HY-10019S1

Varenicline-15N,13C,d2

Varenicline- ¹⁵N, ¹³C,d₂ is ¹⁵N and deuterated labeled Varenicline (HY-10019). Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC₅₀=250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation .

HY-10020S

Varenicline-15N3 hydrochloride

Varenicline-15N3 Hydrochloride (CP 526555-15N3 Hydrochloride) is the ¹⁵N labeled isotope of Varenicline hydrochloride (HY-10020). Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC₅₀ = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82914

	*Nicotinic Acetylcholine* Receptor alpha 5 Antibody (YA2659)** CHRNA5; NACHRA5; Neuronal acetylcholine receptor subunit alpha-5	WB, IP, FC	Human, Mouse, Rat
	Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA2659) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2659), targeting Nicotinic Acetylcholine Receptor alpha 5, with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA2659) can be used for WB, IP, FC experiment in human, mouse, rat background.

HY-P81142

	*Muscarinic Acetylcholine* receptor M3 Antibody** Muscarinic acetylcholine receptor M3; cholinergic receptor, muscarinic 3; CHRM 3; CHRM3; HM 3; HM3; HM3; EGBRS; M3 muscarinic receptor; muscarinic 3; m3 muscarinic acetylcholine receptor; ACM3_HUMAN; muscarinic receptor M3; muscarinic cholinergic m3 receptor; muscarinic m3 receptor; acetylcholine receptor(M3).	WB	Human
	Muscarinic Acetylcholine receptor M3 Antibody is an unconjugated, approximately 66 kDa, rabbit-derived, anti-Muscarinic Acetylcholine receptor M3 monoclonal antibody. Muscarinic Acetylcholine receptor M3 Antibody can be used for: WB expriments in human background without labeling.

HY-P82865

	*Muscarinic Acetylcholine* Receptor M2 Antibody (YA2610)** CHRM2; HM2; AChR; Acm2	WB, IHC-P, IP	Human, Mouse, Rat
	Muscarinic Acetylcholine Receptor M2 Antibody (YA2610) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2610), targeting Muscarinic Acetylcholine Receptor M2, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). Muscarinic Acetylcholine Receptor M2 Antibody (YA2610) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P82871

	*Nicotinic Acetylcholine* Receptor alpha 4 Antibody (YA2616)** ACH4; AChR; Acra4; BFNC; CHRNA4; EBN; EBN1; NACHR; NACRA4	WB, IP	Human, Mouse, Rat
	Nicotinic Acetylcholine Receptor alpha 4 Antibody (YA2616) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2616), targeting Nicotinic Acetylcholine Receptor alpha 4, with a predicted molecular weight of 70 kDa (observed band size: 70 kDa). Nicotinic Acetylcholine Receptor alpha 4 Antibody (YA2616) can be used for WB, IP experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-134061

Arecaidine propargyl ester hydrobromide		Alkynes
Arecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors and has the activity of inhibiting tumor cell proliferation. The application of arecaidine propargyl ester hydrobromide has shown that it can reduce the number of ovarian cancer cells in vitro and induce apoptosis and the production of reactive oxygen species (ROS) at specific concentrations. Arecaidine propargyl ester hydrobromide can also arrest cells at the G2/M phase of the cell cycle and increase the percentage of abnormal mitosis. Arecaidine propargyl ester hydrobromide is more sensitizing to ovarian surface epithelial cells with higher M2 receptor levels than to cancer cells. Arecaidine propargyl ester hydrobromide exhibits the effect of lowering arterial blood pressure when interacting with the cardiovascular system in a natural physiological state, indicating its potential pharmacological application .

Cat. No.	Product Name		Classification

HY-N2338

Cholesterol myristate Cholesteryl myristate; Cholesteryl tetradecanoate		Cholesterol
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the *nicotinic acetylcholine* receptor, GABAA receptor, and the inward-rectifier potassium ion channel**.

HY-148412A

Monarsen sodium EN101 sodium; ODN 7040 sodium; BL 7040 sodium		Antisense Oligonucleotides
Monarsen sodium is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen sodium is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).

HY-148412

Monarsen EN101; ODN 7040; BL 7040		Antisense Oligonucleotides
Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).

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