Search Result

Results for "

1c

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (1) 5-HT Receptor (26) ADC Linker (5) Adrenergic Receptor (1) Aldose Reductase (15) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (21) Autophagy (7) Bacterial (10) Biochemical Assay Reagents (2) c-Fms (1) c-Kit (2) c-Met/HGFR (3) c-Myc (3) Calcium Channel (4) CaMK (1) Casein Kinase (1) CCR (4) CDK (1) Complement System (9) Cytochrome P450 (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (5) Dopamine Receptor (4) Dynamin (1) E3 Ligase Ligand-Linker Conjugates (7) EGFR (3) Endogenous Metabolite (31) Enteropeptidase (1) ERK (2) Fatty Acid Synthase (FASN) (1) FGFR (1) Fluorescent Dye (6) FXR (3) GLP Receptor (2) Hexokinase (1) Histamine Receptor (1) Histone Demethylase (1) HIV (1) HSP (1) HSV (1) IKK (1) Influenza Virus (2) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (34) Keap1-Nrf2 (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) Liposome (1) LPL Receptor (1) LXR (1) MEK (2) Melatonin Receptor (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) Mitophagy (2) Mixed Lineage Kinase (1) mTOR (2) Mucin (1) Na+/K+ ATPase (1) NF-κB (1) Nucleoside Antimetabolite/Analog (4) Orthopoxvirus (1) P-glycoprotein (1) PAI-1 (1) PAK (1) Parasite (1) PARP (1) Phosphatase (2) Phosphodiesterase (PDE) (9) Phospholipase (1) PI3K (3) PIKfyve (2) Pim (1) PKC (1) Potassium Channel (2) PPAR (1) PROTAC Linkers (23) PROTACs (2) Proteasome (1) Proton Pump (1) Raf (1) RAR/RXR (1) Ras (1) Reactive Oxygen Species (4) ROS Kinase (1) RXFP Receptor (1) SARS-CoV (1) Ser/Thr Protease (1) Sirtuin (1) Small Interfering RNA (siRNA) (37) Sodium Channel (2) TAM Receptor (1) TRP Channel (1) VEGFR (2) β-catenin (1)
By Research Areas:	Cancer (122) Cardiovascular Disease (11) Endocrinology (4) Infection (9) Inflammation/Immunology (33) Metabolic Disease (26) Neurological Disease (49)
Click Chemistry:	ADC Synthesis (1) DBCO (1) PROTAC Synthesis (6) Azide (6) Alkynes (1)
Oligonucleotides:	Nucleosides and their Analogs (2) Pre-designed siRNA Sets (37) siRNAs (37)

301

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

114

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139598

LFHP-1c	Phospholipase	Cardiovascular Disease
LFHP-1c is an PGAM5 inhibitor with neuroprotective activity in brain ischemic stroke. LFHP-1c protects blood-brain barrier integrity from ischemia-induced injury. LFHP-1c binds to endothelial PGAM5 to inhibit the activity of PGAM5 phosphatase and the interaction of PGAM5 with NRF2. LFHP-1c exhibits in vitro and in vivo protection ^[1].

HY-P99362

Ensituximab Anti-MUC5AC Reference Antibody (ensituximab); NEO-102	Mucin Others	Cancer
Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer ^[1] .

HY-17429

Flecainide acetate 1 Publications Verification R-818	Sodium Channel	Cardiovascular Disease
Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

HY-148087

AZD5462	RXFP Receptor	Cardiovascular Disease
AZD5462 is a *RXFP1* modulator, can be used for heart failure research. *RXFP1* is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties ^[1].

HY-N11537

2-Methoxy-6-pentadecyl-1,4-benzoquinone	Others	Others
2-Methoxy-6-pentadecyl-1,4-benzoquinone (1c) is a pentadecyl derivative that can be isolated from seed oils of different iris plants such as I. pseudacorus, I. missouriensis and I. sibirica ^[1].

HY-U00374

Sch59498	Phosphodiesterase (PDE)	Neurological Disease
Sch59498 is a potent inhibitor of phosphodiesterase 1c (Pde1c).

HY-N11583

Jasmololone Jasmololon	Others	Others
Jasmololone (compound 1c) is a reduced compound that can be oxidized by manganese dioxide to form the corresponding diketone ^[1].

HY-163619

Anticancer agent 227	Apoptosis Mitophagy	Cancer
Anticancer agent 227 (compound YNU-1c) is a potent anticancer agent. Anticancer agent 227 shows antiproliferative activity. Anticancer agent 227 induces apoptosis and mitophagy ^[1].

HY-147931

Human enteropeptidase-IN-2	Enteropeptidase	Metabolic Disease
Human enteropeptidase-IN-2 (compound 1c) is a highly potent enteropeptidase inhibitor. Human enteropeptidase-IN-2 can be used for anti-obesity research ^[1].

HY-111049

GSK8062	FXR	Metabolic Disease
GSK8062 is a farnesoid X receptor (FXR) agonist with activity that improves compound development parameters. Analog 1c of GSK8062 showed a reduction in weight gain and serum glucose levels ^[1].

HY-100980

HEAT hydrochloride BE2254 hydrochloride	Adrenergic Receptor	Neurological Disease Cancer
HEAT (BE2254) hydrochloride is a selective _{alpha 1 adrenergic receptor} antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pK_is of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively ^[1] .

HY-P99614

Fazpilodemab BFKB8488A	FGFR	Metabolic Disease
Fazpilodemab (BFKB8488A) is a humanized, agonistic, bispecific antibody targeting fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD) ^[1].

HY-148326

Glu(OtBu)-Val-Cit-PAB-OH	ADC Linker	Others
Glu(OtBu)-Val-Cit-PAB-OH (compound L5-1c) is an non-cleavable ADC linker. Glu(OtBu)-Val-Cit-PAB-OH has been used to synthesis protein-tubulysin conjugates ^[1].

HY-163674

Mincle agonist 1	Others	Inflammation/Immunology
Mincle agonist 1 (compound 1c) is a Mincle agonist. Mincle agonist 1 can promote IL-1β expression in BMDM cells. Mincle agonist 1 can be used in immune and inflammation related research ^[1].

HY-149900

Antiviral agent 33	Biochemical Assay Reagents	Infection
Antiviral agent 33 (compound 1c) is a double-stranded DNA (dsDNA) virus inhibitor with IC₅₀ values of 0.0790 and 0.1572 µM for VACV and AdV5, respectively. Antiviral agent 33 also has potential for oral administration ^[1].

HY-169159

SIRT6 activator 2	Sirtuin	Metabolic Disease
SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties. SIRT6 activator 2 significantly downregulates LXR, SREBP-1c, and their target genes associated with lipogenesis, and can be used for research related to lipid metabolism-related diseases ^[1].

HY-113567

GSK2324	FXR	Metabolic Disease
GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC₅₀ of 120 nM. GSK2324 exhibits t_1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively ^[1].

HY-B0061

Tandospirone citrate 2 Publications Verification SM-3997 citrate	5-HT Receptor	Neurological Disease
Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM).

HY-N1967

Dihydrocurcumin	Fatty Acid Synthase (FASN)	Metabolic Disease
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways ^[1].

HY-143768

Cap-dependent endonuclease-IN-14	Influenza Virus	Infection
Cap-dependent endonuclease-IN-14 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-14 inhibits the replication of influenza virus. Cap-dependent endonuclease-IN-14 has the potential for the research of viral infections caused by influenza viruses (extracted from patent CN113620948A, compound 1-c) ^[1].

HY-17429R

Flecainide acetate (Standard)	Sodium Channel	Cardiovascular Disease
Flecainide (acetate) (Standard) is the analytical standard of Flecainide (acetate). This product is intended for research and analytical applications. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

HY-111820

CK1-IN-1	Casein Kinase	Inflammation/Immunology
CK1-IN-1 is a casein kinase 1 (CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC₅₀s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively ^[1].

HY-123402

GSK3987 1 Publications Verification	LXR	Metabolic Disease
GSK3987 is a pan LXRα/β agonist with EC₅₀s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation ^[1].

HY-162826

Apoptosis inducer 27	Apoptosis	Cancer
Apoptosis inducer 27 (compound 1c) is a potent inhibitor of MDA-MB-231 breast cancer (IC₅₀: 12.8 μM) and can induce early apoptosis in breast cancer cells. Apoptosis inducer 27 can bind to DNA molecules, Bax and Bcl-2 proteins, and induce DNA damage ^[1].

HY-146495

Antitubercular agent-19	Bacterial	Infection
Antitubercular agent-19 (Compound 1c) is an antitubercular agent. Antitubercular agent-19 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-19 shows low cytotoxicity and relatively high acute lethal toxicity in BALB/c mice ^[1].

HY-155124

Antiproliferative agent-32	Apoptosis	Cancer
Antiproliferative agent-32 (Compound 1c) inhibits the phosphorylation of PI3K/Akt/mTOR signaling pathway. Antiproliferative agent-32 inhibits Huh7 and SK-Hep-1 cells proliferation, and induce cells apoptosis, causes mitochondrial damage. Antiproliferative agent-32 can be used for research of hepatocellular carcinoma ^[1].

HY-136569

DSR-141562	Phosphodiesterase (PDE)	Neurological Disease
DSR-141562 is a novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor. DSR-141562 shows preferential selectivity for human PDE1B with an IC₅₀ of 43.9 nM, and the IC₅₀ values for human PDE1A and 1C are 97.6 and 431.8 nM, respectively. DSR-141562 can be used for the study of positive symptoms, negative symptoms and cognitive impairments associated with schizophrenia ^[1] .

HY-160267

iPAF1C	DNA/RNA Synthesis HIV	Infection
iPAF1C is a potent inhibitor of polymerase-associated factor 1 complex (PAF1C). iPAF1C has anti-HIV activity ^[1].

HY-P3418

CKLF1-C27	CCR ERK	Inflammation/Immunology
CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates *ERK1/2* pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research ^[1].

HY-P3982

CKLF1-C19	CCR	Inflammation/Immunology
CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3 and CCR4 ^[1].

HY-P3418A

CKLF1-C27 TFA	CCR ERK	Inflammation/Immunology
CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates *ERK1/2* pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research ^[1].

HY-163610

AKR1C3-IN-13	Ligands for Target Protein for PROTAC Aldose Reductase	Cancer
AKR1C3-IN-13 (Compound 4) is an *AKR1C3* inhibitor. AKR1C3-IN-13 degrades AKR1C3 in prostate cancer cells ^[1].

HY-P10655

Caloxin 1C2	Proton Pump Calcium Channel	Cardiovascular Disease
Caloxin 1C2 is a specific PMCA (plasma-membrane Ca ²⁺-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The K_i values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca ²⁺ transfer. Caloxin 1C2 affects coronary contractility ^[1] .

HY-157810

AKR1C3-IN-11	Aldose Reductase	Cancer
AKR1C3-IN-11 (Compound 6e) is a Aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 2.0 μM. AKR1C3-IN-11 inhibit cell proliferation in combination with abiraterone (HY-70013). AKR1C3-IN-11 can be used for the research of prostate cancer ^[1].

HY-146573

AKR1C3-IN-6	Others	Cancer
AKR1C3-IN-6 (Compound 1) is a potent, selective *AKR1C3* inhibitor with IC₅₀ values of 0.31 μM and 73.23 μM against AKR1C3 and *AKR1C2, respectively. AKR1C*3-IN-6 shows antitumor activity ^[1].

HY-163323

AKR1C3-IN-12	Aldose Reductase	Cancer
AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer ^[1].

HY-131043

NVS-PAK1-C	PAK	Cancer
NVS-PAK1-C is a potent, ATP-competitive and specific allosteric *PAK1* inhibitor probe with IC₅₀ values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC₅₀=270 nM) and phosphorylated PAK2 (IC₅₀=720 nM) ^[1].

HY-138557

AKR1C3-IN-4	17β-HSD	Cancer
AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research ^[1].

HY-146574

AKR1C3-IN-7	Others	Cancer
AKR1C3-IN-7 (Compound 13) is a potent, selective *AKR1C3* inhibitor with an IC₅₀ of 0.19 μM. AKR1C3-IN-7 shows antitumor activity ^[1].

HY-146575

AKR1C3-IN-8	Others	Cancer
AKR1C3-IN-8 (Compound 5) is a potent, selective *AKR1C3* inhibitor with an IC₅₀ of 0.069 μM. AKR1C3-IN-8 shows antitumor activity ^[1].

HY-152188

AKR1C3-IN-9	Aldose Reductase	Cancer
AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC₅₀ value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line ^[1].

HY-155502

AKR1C3-IN-10	Aldose Reductase	Cancer
AKR1C3-IN-10 (compound 5r) is a selective *AKR1C3* inhibitor (IC₅₀=51 nM). AKR1C3-IN-10 shows good activity in a prostate cancer xenograft model ^[1].

HY-114009

AKR1C1-IN-1	Others	Neurological Disease
AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a K_i value of 4 nM for AKR1C1 ^[1].

HY-163784

AKR1C3-IN-14	Aldose Reductase	Cancer
AKR1C3-IN-14 (compound 4) is an *AKR1C3* inhibitor (IC₅₀=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the *AKR1C3* enzyme, thereby regulating hormone-mediated signaling. AKR1C3-IN-14 also plays a role in the biosynthesis of the prostaglandin PGF2α, regulating cell proliferation by affecting this pathway. AKR1C3-IN-14 can be used in the study of prostate cancer ^[1].

HY-107379

AKR1C3-IN-1 1 Publications Verification	Others	Others
AKR1C3-IN-1 is a potent, highly selective inhibitor of *AKR1C3, with an IC₅₀* of 13 nM.

HY-149028

Mem-C1C18	Fluorescent Dye	Others
Mem-C1C18 is a polarity-sensitive fluorescent probe with excellent plasma membrane anchoring, high brightness and a sensitive response to environmental polarity by altering the fluorescence lifetime. Mem-C1C18 can be used to quantify changes in the polarity of the plasma membrane during iron death ^[1].

HY-121656

AKR1C2/3-IN-2	Endogenous Metabolite	Cancer
AKR1C2/3-IN-2 is a potential AKR1C3 inhibitor with selective AKR1C3 activity. AKR1C2/3-IN-2 is able to block AKR1C3-mediated testosterone (T) production and PSA induction, affecting the endocrine activity of prostate cancer cells. AKR1C2/3-IN-2 shows selectivity over other AKR1C enzymes, indicating its potential application in inhibiting drug-resistant prostate cancer. AKR1C2/3-IN-2 has no inhibitory activity against COX isomerases, further emphasizing its specificity as a prostate cancer inhibitory compound ^[1].

HY-161839

AKR1C2/3-IN-1	Aldose Reductase	Cancer
AKR1C2/3-IN-1 (compound 3a) is a potent *AKR1C2* and *AKR1C3* inhibitor with IC₅₀ values of 90, 50 nM, respectively. AKR1C2/3-IN-1 can be used as a radiation sensitizer and as a potentiator of chemotherapy cytotoxicity ^[1].

HY-144749

AKR1C3-IN-5	Aldose Reductase	Cancer
AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of *AKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC₅₀*) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells ^[1].

HY-140002

Amino-PEG1-C2-acid	PROTAC Linkers	Cancer
Amino-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1967

Dihydrocurcumin	Zingiber officinale Roscoe Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Zingiberaceae	Fatty Acid Synthase (FASN)
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways ^[1].

HY-N0376

Liquiritin Maximum Cited Publications 6 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Monophenols Flavonoids Leguminosae Flavonones Phenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive *AKR1C1* inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo ^[1]. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-100971

Spiramide AMI-193	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Source classification Rosaceae Spiraea japonica Plants Disease Research Fields	5-HT Receptor Dopamine Receptor
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT₂ and dopamine D2 receptor, with K_is of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT₂ versus *5-HT_1C* (K_i=4300 nM) receptors. Spiramide exhibits antipsychotic activity ^[1] .

HY-N10361

Drupanin	Monophenols Animals Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	RAR/RXR PPAR Aldose Reductase
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers ^[1] .

HY-N0330

Momordin Ic 3 Publications Verification	Kochia scoparia L. Schrad. Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Chenopodiaceae Cancer	Apoptosis Autophagy PI3K c-Myc
Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, *SENP1/c-MYC* signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity ^[1] .

HY-N11583

Jasmololone Jasmololon	Structural Classification Natural Products Source classification Plants Compositae Bidens parviflora Willd.	Others
Jasmololone (compound 1c) is a reduced compound that can be oxidized by manganese dioxide to form the corresponding diketone ^[1].

HY-N0376R

Liquiritin (Standard)	Structural Classification Monophenols Flavonoids Leguminosae Flavonones Source classification Phenols Plants Glycyrrhiza uralensis Fisch.	Reactive Oxygen Species
Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo ^[1]. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-N10344

Glucoarabin	Structural Classification Natural Products Classification of Application Fields Source classification Camelina sativa (L.) Crantz Glucosinolates Plants Brassicaceae Disease Research Fields Cancer	Cytochrome P450
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity ^[1].

HY-N6802

Tigloylgomisin H	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Keap1-Nrf2
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent ^[1].

HY-N0330R

Momordin Ic (Standard)	Kochia scoparia L. Schrad. Triterpenes Structural Classification Terpenoids Source classification Plants Chenopodiaceae	Apoptosis Autophagy PI3K c-Myc
Momordin Ic (Standard) is the analytical standard of Momordin Ic. This product is intended for research and analytical applications. Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl4 (HY-Y0298) induced hepatotoxicity and anti-tumor activity ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-N0305S3

5-Aminolevulinic acid-13C-1 hydrochloride
5-Aminolevulinic acid- ¹³C-1 (5-ALA- ¹³C-1) hydrochloride is the ¹³C labeled 5-Aminolevulinic acid hydrochloride ^[1]. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles .

HY-B1449S2

Uridine-13C-1
Uridine- ¹³C-1 is the ¹³C labeled Uridine[1].

HY-I0400S1

N-Acetylneuraminic acid-13C-1
N-Acetylneuraminic acid- ¹³C-1 is the ¹³C labeled N-Acetylneuraminic acid.

HY-B0400AS1

L-Sorbitol-13C-1
L-Sorbitol- ¹³C-1 is the ¹³C labeled L-Sorbitol[1].

HY-W012584S1

L-Arabinopyranose-13C-1
L-Arabinopyranose- ¹³C-1 is the ¹³C labeled L-Arabinopyranose[1].

HY-W142434S

D-Galactose-13C-1
D-Galactose- ¹³C-1 is the ¹³C labeled D-galactopyranose[1].

HY-N6614S1

L-Galactose-13C-1
L-Galactose- ¹³C-1 is the ¹³C labeled L-Galactose[1].

HY-146994S1

L-Idose-13C-1
L-Idose- ¹³C-1 is the ¹³C labeled L-Idose[1].

HY-N0059AS1

L-(+)-Lyxose-13C-1
L-(+)-Lyxose- ¹³C-1 is the ¹³C labeled L-Lyxose[1].

HY-W016508S1

L-(-)-Mannose-13C-1
L-(-)-Mannose- ¹³C-1 is the ¹³C labeled L-(-)-Mannose[1].

HY-W145492S3

D-(+)-Talose-13C-1
D-(+)-Talose- ¹³C-1 is the ¹³C labeled D-(+)-Talose[1].

HY-77956S1

Thyminose-13C-1
Thyminose- ¹³C-1 is the ¹³C labeled Thyminose. Thyminose is an endogenous metabolite[1].

HY-128741S1

D-Allose-13C-1
D-Allose- ¹³C-1 is the ¹³C labeled D-Allose. D-Allose is an endogenous metabolite[1].

HY-N0059S1

D-Arabinose-13C-1
D-Arabinose- ¹³C-1 is the ¹³C labeled D-arabinose. D-arabinose is an endogenous metabolite[1].

HY-B1732S3

DL-3-Phenylalanine-13C-1
DL-3-Phenylalanine- ¹³C-1 is the ¹³C labeled DL-3-Phenylalanine[1].

HY-W039909S1

Tri-O-acetyl-D-galactal-13C-1
Tri-O-acetyl-D-galactal- ¹³C-1 is the ¹³C labeled Tri-O-Acetyl-D-galactose[1].

HY-N7092S2

D-Fructose-13C-1
D-Fructose- ¹³C-1 is the ¹³C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.

HY-W013378S5

Carbamazepine 10,11-epoxide-13C-1
Carbamazepine 10,11-epoxide- ¹³C-1 is the ¹³C labeled Carbamazepine 10,11-epoxide (HY-W013378)[1].

HY-Y0418S1

Dulcite-13C-1
Dulcite- ¹³C-1 is the ¹³C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].

HY-B1659S2

Glycerol-13C-1
Glycerol- ¹³C-1 is the ¹³C labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[1][2][3][4].

HY-N3686S1

D-Arabitol-13C-1
D-Arabitol- ¹³C-1 is the ¹³C labeled D-Arabitol. D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in hu[1][2].

HY-113143AS1

Galactose 1-phosphate-13C-1 potassium
Galactose 1-phosphate- ¹³C-1 (potassium) is the ¹³C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug[1][2].

HY-B2227BS3

Lactate-13C-1 sodium
Lactate- ¹³C-1 (sodium) is the ¹³C labeled Lactate (sodium)[1]. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate (Lactic acid) sodium functions in a variety of biochemical processes[2].

HY-W010042S1

L-Glucose-13C-1
L-Glucose- ¹³C-1 is the ¹³C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake[1][2].

HY-N0666S10

L-Aspartic acid-C13-1
L-Aspartic acid- ¹³C-1 is the deuterium labeled L-Aspartic acid[1]. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly[2][3].

HY-34628S1

Tri-O-acetyl-D-glucall-13C-1
3,4,6-Tri-O-acetyl-D-glucal- ¹³C-1 is the ¹³C labeled 3,4,6-Tri-O-acetyl-D-glucal[1].

HY-N0379S6

D-Mannose-13C-1
D-Mannose- ¹³C-1 is the ¹³C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].

HY-N1446S4

Oleic acid-13C-1
Oleic acid- ¹³C-1 is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid ^[1]. Oleic acid is a Na+/K+ ATPase activator .

HY-N1480S1

(-)-Fucose-13C-1
(-)-Fucose- ¹³C-1 is the ¹³C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[

HY-B0158S2

Cytidine-13C-1
Cytidine- ¹³C-1 is the ¹³C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami

HY-111095S2

D-(-)-Lactic acid-13C-1
D-(-)-Lactic acid- ¹³C-1 is the ¹³C labeled D-(-)-Lactic acid. D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants ^[1].

HY-Y0366S4

Lauric acid-13C-1
Lauric acid- ¹³C-1 is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively[1].

HY-42680S1

D-Tagatose-13C-1
D-Tagatose- ¹³C-1 is the ¹³C labeled D-Tagatose. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit jui

HY-128850S2

N-Acetyl-D-mannosamine-13C-1
N-Acetyl-D-mannosamine- ¹³C-1 is the ¹³C labeled N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1][2]

HY-W012864S1

(2S,3R)-2,3,4-Trihydroxybutanal-13C-1
(2S,3R)-2,3,4-Trihydroxybutanal- ¹³C-1 is the ¹³C labeled (2S,3R)-2,3,4-Trihydroxybutanal[1].

HY-B0400S2

D-Sorbitol-13C-1
D-Sorbitol- ¹³C-1 is the ¹³C labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary

HY-W018772S2

D-Ribose-13C-1
D-Ribose- ¹³C-1 is the ¹³C labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein glyca

HY-N1150S3

Thymidine-13C-1
Thymidine- ¹³C-1 is the ¹³C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]

HY-A0132S2

N-Acetyl-D-glucosamine-13C-1
N-Acetyl-D-glucosamine- ¹³C-1 is the ¹³C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].

HY-B0166S2

L-Ascorbic acid-13C-1
L-Ascorbic acid- ¹³C-1 is the ¹³C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen

HY-W007928S1

1-O-Acetyl 2,3,5-tri-O-benzoyl-beta-D-ribofuranoside-13C-1
1-O-Acetyl 2,3,5-tri-O-benzoyl-beta-D-ribofuranoside- ¹³C-1 is the ¹³C labeled 1-O-Acetyl-2,3,5-Tri-O-benzoyl-beta-D-Ribofuranose[1].

HY-13966S4

2-Deoxy-D-glucose-13C-1
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-B0389S11

D-Glucose-13C-1
D-Glucose- ¹³C-1 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

HY-N2362S

DL-Alanine-13C-1

DL-Alanine- ¹³C-1 is the ¹³C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].

HY-W040240S1

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one-13C-1
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- ¹³C-1 is the ¹³C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite[1].

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