Search Result

Results for "

CoV

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SARS-CoV (602) 11β-HSD (3) 5-HT Receptor (3) AAK1 (2) Akt (2) Angiotensin-converting Enzyme (ACE) (10) Antibiotic (15) Apoptosis (26) Autophagy (33) Bacterial (15) Bcr-Abl (3) c-Kit (3) Calcium Channel (2) Casein Kinase (4) Cathepsin (22) CCR (2) CDK (1) Ceramidase (2) Cholinesterase (ChE) (2) COX (3) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (10) Dengue virus (3) Deubiquitinase (1) Dihydroorotate Dehydrogenase (2) DNA Methyltransferase (2) DNA/RNA Synthesis (18) Dopamine Receptor (6) Drug Metabolite (6) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (15) Eukaryotic Initiation Factor (eIF) (1) FAAH (2) Fatty Acid Synthase (FASN) (2) Ferroptosis (2) Filovirus (4) Flavivirus (4) Fluorescent Dye (3) Fungal (4) FXR (3) G protein-coupled Bile Acid Receptor 1 (1) G-quadruplex (1) Glutathione Peroxidase (2) GSK-3 (1) HBV (3) HCV (32) HCV Protease (18) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (10) Histone Demethylase (1) Histone Methyltransferase (2) HIV (49) HIV Protease (28) HSP (1) HSV (5) Influenza Virus (20) Interleukin Related (1) Isotope-Labeled Compounds (30) JNK (1) Keap1-Nrf2 (2) Ligands for Target Protein for PROTAC (2) Liposome (2) Lipoxygenase (2) MDM-2/p53 (1) Mitophagy (2) MMP (5) nAChR (1) NF-κB (2) Nucleoside Antimetabolite/Analog (2) Opioid Receptor (2) Orthopoxvirus (1) P-glycoprotein (6) p38 MAPK (1) PAI-1 (1) Parasite (39) PDGFR (3) Phosphatase (3) PI3K (1) PIKfyve (2) PKC (2) Potassium Channel (3) PROTAC Linkers (1) PROTACs (5) Proteasome (1) Ras (1) Reactive Oxygen Species (2) Reverse Transcriptase (4) ROR (2) ROS Kinase (3) RSV (3) Ser/Thr Protease (13) Sigma Receptor (3) Sirtuin (4) Sodium Channel (7) STING (10) Telomerase (1) Thrombopoietin Receptor (2) Toll-like Receptor (TLR) (20) Topoisomerase (3) TRP Channel (1) VEGFR (2) Virus Protease (34)
By Research Areas:	Cancer (116) Cardiovascular Disease (16) Endocrinology (12) Infection (578) Inflammation/Immunology (83) Metabolic Disease (35) Neurological Disease (20)
Click Chemistry:	Azide (3) Alkynes (3)
Oligonucleotides:	Cationic Lipids (2)

654

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

215

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: SARS-CoV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99604

Cilgavimab AZD-1061; CoV2-2130	SARS-CoV	Infection
Cilgavimab (AZD-1061; COV2-2130) is a human *SARS-CoV-2*-neutralizing monoclonal antibody, can compose monoclonal-antibody combination AZD7442 with Tixagevimab (HY-P99556). Cilgavimab shows protective action on mouse models of *SARS-CoV-2* infection .

HY-W728005

Covidcil-19	SARS-CoV	Infection
Covidcil-19 (compound C5) avidly binds to the revised attenuator hairpin structure of the *SARS-CoV-2 frameshifting element (FSE)* with a K_d of 11 nM. Covidcil-19 stabilizes the hairpin’s folded state and impairs frameshifting in cells. Covidcil-19 reduces frameshifting efficiency of the SARS-CoV-2 FSE and does not affect SARS-CoV-2 FSE RNA levels. Covidcil-19 inhibits a process essential for SARS-CoV-2 viral propagation .

HY-P99104

Plutavimab CoVI-AMG; STI-2020	SARS-CoV	Infection
Plutavimab a human IgG1-κ anti-SARS-CoV-2 antibody, targeting to Spike (S) glycoprotein receptor binding domain (RBD) .

HY-157805

*PROTAC SARS-CoV-2 Mpro degrader-2*	PROTACs SARS-CoV	Infection
PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of *SARS-CoV-2 M ^pro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC₅₀* = 10.8 μM), HCoV-OC43 (EC₅₀ = 1.6 μM) and HCoV-229E (EC₅₀ = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC₅₀ of 0.89 μM .

HY-162924

*SARS-CoV-IN-6*	SARS-CoV	Infection
SARS-CoV-IN-6 (Compound 17) is an inhibitor of *SARS-CoV-1* and *SARS-CoV-2* RdRp, with an IC₅₀ value of 7.8 μM against SARS-CoV-2 RdRp. SARS-CoV-IN-6 reduces cytopathic effects in cells infected with SARS-CoV-1 and SARS-CoV-2 replicon-based single-round infectious particles (SRIPs), and inhibits SARS-CoV N protein expression, with EC₅₀ values of 0.12 µM for SARS-CoV-1 replicon-based SRIPs and 1.47 µM for SARS-CoV-2 replicon-based SRIPs .

HY-162674

*MERS-CoV-IN-2*	SARS-CoV	Infection
MERS-CoV-IN-2 (compound 3c) is a *MERS-CoV* 3CLpro inhibitor (IC₅₀*=17nM). MERS-CoV-IN-2 inhibits the activity of the 3CLpro* enzyme by binding to the active site of the enzyme, specifically the S4 subsite, thereby exhibiting antiviral activity against SARS-CoV-2 and MERS-CoV .

HY-155308

*SARS-CoV-2-IN-61*	SARS-CoV	Infection
SARS-CoV-2-IN-61 (compound 8i) is a *SARS CoV-2 PLpro* inhibitor with an IC₅₀ of 16 µM. SARS-CoV-2-IN-61 has antiviral activities .

HY-150783

*SARS-CoV-2-IN-24*	SARS-CoV	Infection
SARS-CoV-2-IN-24 (compound 7) is a potent papain-like protease (PL ^pro) inhibitor. SARS-CoV-2-IN-24 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. SARS-CoV-2-IN-24 can be used for SARS-CoV-2 research .

HY-135860

*SARS-CoV-2-IN-1*	Virus Protease SARS-CoV	Infection
SARS-CoV-2-IN-1 is a potent Mpro inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC₅₀s of 0.67, 0.90 and 0.58 μM, respectively .

HY-159477

*SARS-CoV-2-IN-92*	SARS-CoV	Infection Inflammation/Immunology
SARS-CoV-2-IN-92 (compound 11) inhibits *SARS-CoV-2* variants (EC₅₀ = 0.48 μM), as well as SARS-CoV and MERS-CoV. SARS-CoV-2-IN-92 (compound 11) potently and selectively blocks ERα-Glu II .

HY-122872

*MKK7-COV-9*	p38 MAPK	Cancer
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM .

HY-155119

*SARS-CoV-2-IN-54*	SARS-CoV	Infection
SARS-CoV-2-IN-54 (Compound 2) is a *SARS-CoV-2* inhibitor. SARS-CoV-2-IN-54 has antiviral activity. SARS-CoV-2-IN-54 inhibits SARS-CoV-2 in Vero E6 cells, with an IC₅₀ of 21.4 μM .

HY-155121

*SARS-CoV-2-IN-56*	SARS-CoV	Infection
SARS-CoV-2-IN-56 (Compound 63) is a *SARS-CoV-2* inhibitor. SARS-CoV-2-IN-56 has antiviral activity. SARS-CoV-2-IN-56 inhibits SARS-CoV-2 in Vero E6 cells, with an IC₅₀ of 0.7 μM .

HY-143467

*SARS-CoV-IN-4*	SARS-CoV	Infection
SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of *SARS-CoV* nsp14 N7-methyltransferase, with an IC₅₀** of 0.6 μM (SARS-CoV nsp14) .

HY-162295

*SARS-CoV-2-IN-83*	SARS-CoV	Infection
SARS-CoV-2-IN-83 (compound C6E) has excellent activity against SARS CoV-2 spike protein .

HY-149954

*SARS-CoV-2-IN-39*	SARS-CoV	Infection
SARS-CoV-2-IN-39 (compound 21) is a *SARS-CoV-2* inhibitor with an EC₅₀ of 1 μM. SARS-CoV-2-IN-39 against SARS-CoV-2 by inhibiting of SKP2 protein and stabilizing BECN1 .

HY-163913

*SARS-CoV-IN-5*	SARS-CoV	Infection
SARS-CoV-IN-5 (compound 49) is a highly selective, nonpeptidic and noncovalent 3CL ^pro inhibitor with IC₅₀s of 38 nM, 21.1 nM and 86 nM for 3CL ^pro of SARS-CoV-1, SARS-CoV-2, Bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the *SARS-CoV-2 delta* variant with an EC₅₀ of 0.272 μM. SARS-CoV-IN-5 significantly reduces the lung viral copies in a K18-hACE2 transgenic mouse model. SARS-CoV-IN-5 has good target-specific and potential broad-spectrum anticoronavirus activities against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9 .

HY-136606

*SARS-CoV* MPro-IN-1**	SARS-CoV	Infection
SARS-CoV MPro-IN-1 is a *SARS-CoV-2 3CLpro* covalent inhibitor, with an IC₅₀ of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC₅₀ of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research .

HY-162790

*SARS-CoV-2-IN-95*	SARS-CoV Virus Protease	Infection
SARS-CoV-2-IN-95 (Compound 10) is an inhibitor for *SARS-CoV-2 PLpro* with an IC₅₀ of 0.39 μM. SARS-CoV-2-IN-95 exhibits antiviral activity in mouse SARS-CoV-2-infected model .

HY-156008

*SARS-CoV-2-IN-58*	SARS-CoV Virus Protease	Infection
SARS-CoV-2-IN-58 (Compound 21H) is an antiviral agent against *SARS-CoV-2* (EC₅₀: 18 μM). SARS-CoV-2-IN-58 inhibits SARS-CoV-2 M ^pro with an IC₅₀ of 0.35 μM .

HY-163713

*SARS-CoV-2-IN-89*	SARS-CoV	Infection
SARS-CoV-2-IN-89 (Compound 2) is a *SARS-CoV-2* inhibitor. SARS-CoV-2-IN-89 enhances IFN-I responses to SARS-CoV-2 infection in A549.hACE2 cells .

HY-151988

*SARS-CoV-2-IN-36*	SARS-CoV	Infection
SARS-CoV-2-IN-36 is a potent *SARS-CoV-2 Mpro* (SARS-CoV) inhibitor with an IC₅₀ of 2.37 μM and a K_d of 1.19 μM in enzymatic assays. SARS-CoV-2-IN-36 shows antiviral activity against UC-1074, RG2674, and NVDBB-2220 SARS-CoV-2 variants in Vero cells .

HY-P3492

*SARS-CoV-2-IN-34*	SARS-CoV	Infection
SARS-CoV-2-IN-34 (S-20-1) is a blood brain barrier penetrable *pan-coronavirus (CoV) fusion* inhibitor with broad-spectrum inhibitory activity. SARS-CoV-2-IN-34 effectively inhibits infection by pseudotyped and authentic SARS-CoV-2, and pseudotyped variants of concern (VOCs). SARS-CoV-2-IN-34 shows high affinity to RBD in S1 and HR1 domain in S2 of SARS-CoV-2 S protein. SARS-CoV-2-IN-34 can be used for the research of infection .

HY-139908

*MERS-CoV-IN-1*	SARS-CoV	Infection
MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus. MERS-CoV-IN-1 is useful as a pharmaceutical composition for preventing coronavirus-induced diseases (MERS-CoV and SARS) (extracted from patent WO2018174442A1, compound 1) .

HY-155015

*SARS-CoV-2-IN-45*	SARS-CoV	Infection
SARS-CoV-2-IN-45 (Compound 8p) is a *SARS-CoV-2* inhibitor. SARS-CoV-2-IN-45 inhibits SARS-CoV-2 replication in Calu-3 cell with an EC₅₀ of 0.5 μM, and has no evident cytotoxic effect .

HY-162154

*SARS-CoV-2-IN-75*	SARS-CoV	Infection
SARS-CoV-2-IN-75 (compound 13) is a *SARS-CoV-2* inhibitor based on chloroacetamide inhibition. SARS-CoV-2-IN-75 inhibits cellular SARS-CoV-2 replication with an EC₆₈ (half-log reduction in viral titer) of 3 μM .

HY-163857

*SARS-CoV-2-IN-91*	SARS-CoV	Infection
SARS-CoV-2-IN-91 (Compound 194) is an inhibitor for *SARS-CoV* 2 with an EC₅₀** of 28.92 μM. SARS-CoV-2-IN-91 inhibits the viral -1 programmed ribosome frame shift (-1PRF) element, and thereby inhibits the replication of SARS-CoV 2 .

HY-162604

*SARS-CoV-2-IN-90*	SARS-CoV	Infection
SARS-CoV-2-IN-90 (compound 3i) is a *SARS-CoV-2* inhibitor. SARS-CoV-2-IN-90 can be used in coronavirus infection related research .

HY-135858

*SARS-CoV-IN-3* 1 Publications Verification	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-3 is an effective inhibitor of *SARS-CoV* replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC₅₀ of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 11.7 and 20.4 nM; and IC₉₀s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 10 μM in MT-4 cells .

HY-162177

*SARS-CoV-2-IN-78*	SARS-CoV	Infection
SARS-CoV-2-IN-78 (compound 3) is an inhibitor for nsp14 of *SARS-Cov-2. SARS-CoV*-2-IN-78 reveals antiviral activity as N7 methyltrabsferase .

HY-162414

*SARS-CoV-2-IN-84*	SARS-CoV	Infection
SARS-CoV-2-IN-84 (compound 20) is aSARS-CoV-2 inhibitor that targets the 3CL protease (3CL Pro) of SARS-CoV-2 (IC₅₀: 369.5 nM ) .

HY-162777

*SARS-CoV-2-IN-93*	SARS-CoV	Infection
SARS-CoV-2-IN-93 (compound 24) is an inhibitor of *SARS-CoV-2* and HCoV-OC43. SARS-CoV-2-IN-93 can be used in antiviral research .

HY-149304

*SARS-CoV-2-IN-40*	SARS-CoV	Infection
SARS-CoV-2-IN-40 (Compound 19) is a *SARS-CoV-2* inhibitor. SARS-CoV-2-IN-40 inhibits SARS-CoV-2 BA.1 and BA.5 variant infection of Calu3 lung cells, with IC₅₀s of 100 nM and 160 nM respectively .

HY-169224

*SARS-CoV-2-IN-100*	SARS-CoV	Infection
SARS-CoV-2-IN-100 (Compound 172) is an inhibitor of *SARS-CoV-2, demonstrating broad-spectrum antiviral activity against various SARS-CoV-2* variants. SARS-CoV-2-IN-100 exhibits synergistic effects with Nirmatrelvir, which can reduce the risk of antiviral drug resistance .

HY-146379

*SARS-CoV-2-IN-19*	SARS-CoV	Infection
SARS-CoV-2-IN-19 (Compound 6g) is a potent inhibitor of *SARS-CoV-2* with an EC₅₀ of 8.8 μM. SARS-CoV-2-IN-19 shows potent activity against SARS-CoV-2 helicase (nsp13), a highly conserved enzyme, highlighting a potentiality against emerging HCoVs outbreaks. SARS-CoV-2-IN-19 has the potential for the research of infection diseases .

HY-143417

*SARS-CoV-2-IN-16*	SARS-CoV	Infection
SARS-CoV-2-IN-16 (Compound 12) is a potent *SARS-CoV-2* nucleocapsid protein (NPro) inhibitor. SARS-CoV-2-IN-16 exhibits potent anti-viral activity with the EC₅₀ of 3.69 μM. SARS-CoV-2-IN-16 binds to NPro with the low K_D value of 7.82 μM, suggesting that SARS-CoV-2-IN-16 is a potent NPro ligand .

HY-143418

*SARS-CoV-2-IN-17*	SARS-CoV	Infection
SARS-CoV-2-IN-17 (Compound 16) is a potent *SARS-CoV-2* nucleocapsid protein (NPro) inhibitor. SARS-CoV-2-IN-17 exhibits potent anti-viral activity with the EC₅₀ of 2.18 μM. SARS-CoV-2-IN-17 binds to NPro with the low K_D value of 7.82 μM, suggesting that SARS-CoV-2-IN-17 is a potent NPro ligand .

HY-135855

*SARS-CoV-IN-1* 1 Publications Verification	SARS-CoV Parasite	Infection
SARS-CoV-IN-1 is an effective inhibitor of *SARS-CoV* replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC₅₀ of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 15.4 and 133.2 nM; and IC₉₀s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities .

HY-157022

*SARS-CoV-2-IN-67*	SARS-CoV	Infection
SARS-CoV-2-IN-67 (Compound 16), a vitamin K derivatives, has anti-SARS-CoV-2 activity (EC₅₀: 64.8 μM in VeroE6/TMPRSS2 cells). SARS-CoV-2-IN-67 inhibits SARS-CoV-2 RdRp activity .

HY-157145

*SARS-CoV-2-IN-69*	SARS-CoV	Infection
SARS-CoV-2-IN-69 (Compound 7E) is a non-covalent *SARS-CoV-2* inhibitor with an EC₅₀ value of 7.4 μM. SARS-CoV-2-IN-69 is a potent inhibitor of SARS-CoV-2 main protease (M ^pro) and a non-covalent inhibitor of papain (PL ^pro) .

HY-163067

*SARS-CoV-2-IN-71*	SARS-CoV	Infection
SARS-CoV-2-IN-71 (compound 8h) is a potent inhibitor of *SARS-CoV-2. SARS-CoV-2-IN-71 inhibits coronavirus replication at multiple stages. SARS-CoV-2-IN-71 displays anti-coronaviral effect by simultaneously acting on 3CL ^pro* and TMPRSS2 .

HY-135856

*SARS-CoV-IN-2* 1 Publications Verification	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-2 is an effective inhibitor of *SARS-CoV* replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC₅₀ of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 21.5 and 30 nM; and IC₉₀s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities .

HY-146381

*SARS-CoV-2-IN-20*	SARS-CoV	Infection
SARS-CoV-2-IN-20 (Compound 1a) is a potent inhibitor of *SARS-CoV-2* with an EC₅₀ of 6.5 μM. SARS-CoV-2-IN-20 has the potential for the research of infection diseases .

HY-158687

*SARS-CoV-2 Mpro-IN-18*	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-18 (compound 84) is a potent *SARS-CoV-2 Mpro* inhibitor with the IC₅₀ of 3.23 nM. SARS-CoV-2 Mpro-IN-18 can be used for study of anti-SARS-CoV-2 agent .

HY-145276

*SARS-CoV-2-IN-10*	SARS-CoV	Infection
SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of *SARS-CoV-2 3CL protease* (3CLpro) with an IC₅₀ and EC₅₀ of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-145277

*SARS-CoV-2-IN-11*	SARS-CoV	Infection
SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of *SARS-CoV-2 3CL protease* (3CLpro) with an IC₅₀ and EC₅₀ of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-154975

*SARS-CoV-2-IN-49*	SARS-CoV	Others
SARS-CoV-2-IN-49 is an irreversible covalent inhibitor of *SARS-CoV-2* main protease .

HY-162984

*SARS-CoV-2-IN-99*	SARS-CoV	Cancer
SARS-CoV-2-IN-99 (compund 58) is a *SARS-CoV-2* main protease inhibitor .

HY-149315

*SARS-CoV-2-IN-48*	SARS-CoV	Infection
SARS-CoV-2-IN-48 (compound 19) is a *SARS-CoV-2* inhibitor with an IC₅₀ of 2.7 μM for Omicron BA.1. SARS-CoV-2-IN-48 shows antiviral activities .

HY-148387

*SARS-CoV-2-IN-35*	SARS-CoV	Infection
SARS-CoV-2-IN-35 is a potent and orally active *SARS-CoV-2 M ^pro* inhibitor with a K_i value of 12.1 nM. SARS-CoV-2-IN-35 can be used in research of COVID-19 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17470

Mizoribine 4 Publications Verification NSC 289637; HE 69	Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Source classification Inflammation/Immunology Disease Research Fields	HCV SARS-CoV Antibiotic Parasite
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of *SARS-CoV* with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-137984

Cnicin	Structural Classification Natural Products Source classification Centaurea benedicta (L.) L. Plants Compositae	SARS-CoV Apoptosis
Cnicin is an orally bioavailable sesquiterpene lactone. Cnicin has antibacterial and antiproliferative properties and induces apoptosis in primary myeloma cells. Cnicin also exhibits activity against *SARS-CoV-2. Cnicin inhibits the viral replication of SARS CoV-2* with an IC₅₀ of 1.18 μg/mL. Cnicin can promote functional nerve regeneration .

HY-13433

Thapsigargin Maximum Cited Publications 68 Publications Verification	Infection Classification of Application Fields Terpenoids Source classification Diterpenoids Umbelliferae Plants Disease Research Fields Thapsia garganica L. Cancer	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-N144101

*SARS-CoV* MPro-IN-2**	Infection Quinones Classification of Application Fields Source classification Plants Lithospermum canescens Lehm. Naphthalene Quinones Disease Research Fields Boraginaceae	SARS-CoV
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of *SARS-CoV-2 M ^pro* with an IC₅₀ value of 72.07 nM. The main protease (M ^pro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19 .

HY-163742

*SARS-CoV-2 Mpro-IN-22*	Terminalia brownii Fresen. Structural Classification Combretaceae Source classification Phenols Polyphenols Plants	SARS-CoV
SARS-CoV-2 Mpro-IN-22 (compound 4), a hydrolysable tannin, is a potent *SARS-CoV-2 main protease (Mpro)* inhibitor with an IC₅₀ value of 1.2 µg/mL. SARS-CoV-2 Mpro-IN-22 does not show any significant cytotoxic activity against A549 and HUVEC cell lines .

HY-N11896A

10-Hydroxyaloin A	Structural Classification Natural Products Liliaceae Source classification Aloe vera (L.) Burm. f. Plants	SARS-CoV
10-10-Hydroxyaloin A is potent *SARS-CoV-2* inhibitor. 10-Hydroxyaloin A exhibits significant efficacy to bind SARS-Cov-2 M_pro active site .

HY-17470R

Mizoribine (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Source classification	HCV SARS-CoV Antibiotic Parasite
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of *SARS-CoV* with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-126416

Methyl tanshinonate	Structural Classification Natural Products Labiatae Source classification Samanea saman (Jacq.) Merr. Plants	SARS-CoV
Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of M ^pro enzyme in *SARS-CoV* (IC₅₀ = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research .

HY-N3445

Jaceidin triacetate	Sclerocarya birrea (A.Rich.) Hochst. Structural Classification Flavonoids Flavones Source classification Plants Anacardiaceae	SARS-CoV
Jaceidin triacetate(compound 54) is a natural compound isolated formmarulabark.Jaceidin triacetatecan inhibitSARS-CoV-2 Mpro, with theIC₅₀of 11.9μM.Jaceidin triacetateinhibits the replication of Sars-Cov-2 Viral in Vero-E6 cells .

HY-N10118

NK007	Infection Alkaloids Structural Classification Cynanchum mongolicum (Maximowicz) Hemsley Pyrrole Alkaloids Classification of Application Fields Source classification Asclepiadaceae Plants Isoquinoline Alkaloids Disease Research Fields	SARS-CoV
NK007 is a novel anti-SARS-CoV-2 agent with an EC₅₀ value of 30 nM.

HY-A0097

Teicoplanin 1 Publications Verification Antibiotic MDL-507; MDL-507	Infection Structural Classification Microorganisms Source classification Polyphenols Disease Research Fields	Bacterial Antibiotic
Teicoplanin is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-N2949

Bonducellpin D	Other Terpenoids Infection Caesalpinia minax Hance Classification of Application Fields Leguminosae Terpenoids Source classification Plants Disease Research Fields	SARS-CoV
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against *SARS-CoV* M ^pro and MERS-CoV M ^pro, with an K_i** of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro .

HY-A0097A

Teicoplanin sodium Antibiotic MDL-507 sodium; MDL-507 sodium	Structural Classification Source classification Phenols Polyphenols Endogenous metabolite	Antibiotic HIV SARS-CoV
Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-N10604

Dihydromaniwamycin E	Structural Classification Natural Products Microorganisms	Influenza Virus SARS-CoV
Dihydromaniwamycin E is a heat-shock metabolite with antiviral activity against influenza and *SARS-CoV-2* viruses .

HY-126085

(±)-Alliin 2 Publications Verification (±)-L-Alliin	Infection Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields A．Sativam L. var．Viviparum Regel	SARS-CoV
(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of *SARS-CoV-2 (M_pro)* .

HY-N8599

Cichoriin	Infection Structural Classification Monophenols other families Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Plants Disease Research Fields	SARS-CoV
Cichoriin is an active compounds against *SARS-CoV-2*, and may be a potential candidate in researching severe COVID-19 .

HY-N12384

(25S)-Antcin B	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	SARS-CoV
Antcin-B is a potent inhibitor of 3CLPro with high affinity. Antcin-B can be used in study *SARS-CoV-2* .

HY-N1180

Tanshinlactone	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants	SARS-CoV
Tanshinlactone is a seco-abietanoid that can be isolated from Salvia miltiorrhiza. Tanshinlactone is a coronavirus (CoV) inhibitor. Tanshinlactone modulates interleukin-2 and interferon-γ gene expression .

HY-N0360

Dihydrotanshinone I 5 Publications Verification	Cardiovascular Disease Quinones Structural Classification Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Source classification Plants Phenanthrenequinones Disease Research Fields	SARS-CoV
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

HY-W012531

2-Hydroxycinnamic acid	Infection Structural Classification Monophenols Cinnamomum cassia (L.) D. Don Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Lauraceae Disease Research Fields	HIV SARS-CoV Endogenous Metabolite
2-Hydroxycinnamic acid is isolated from the methanol extract of Cinnamomum cassia. 2-Hydroxycinnamic acid shows inhibitory effects on infection of *HIV/SARS-CoV* S pseudovirus with an IC₅₀** of 0.3 mM

HY-W002198

2-Hydroxyacetophenone Phenacyl alcohol	Apocynaceae Carissa edulis Infection Structural Classification Natural Products Classification of Application Fields Plants Disease Research Fields	HIV SARS-CoV
2-Hydroxyacetophenone is a principal root volatile of the Carissa edulis . 2-Hydroxyacetophenone shows inhibitory effects on infection of *HIV/SARS-CoV* S pseudovirus with an IC₅₀** of 1.8 mM .

HY-N2016

Arteannuin B 2 Publications Verification	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields	SARS-CoV Ferroptosis
Arteannuin B, No. 2000 can be jointly submitted with the blue material. Arteannuin B had anti-SARS-CoV-2 activity, EC₅₀=10.28 μM .

HY-126085R

(±)-Alliin (Standard)	Structural Classification Liliaceae Ketones, Aldehydes, Acids Source classification Plants A．Sativam L. var．Viviparum Regel	SARS-CoV
(±)-Alliin (Standard) is the analytical standard of (±)-Alliin. This product is intended for research and analytical applications. (±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro) .

HY-N1910

4'-O-Methylbavachalcone 1 Publications Verification	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields	SARS-CoV
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

HY-N10605

Maniwamycin E	Natural Products Microorganisms	SARS-CoV Influenza Virus
Maniwamycin E is a maniwamycin derivative isolated from the culture extract of thermotolerant Streptomyces sp. JA74. Maniwamycin E shows antiviral activity against SARS-CoV-2 and influenza (H1N1) virus .

HY-B1624A

Debrisoquin hemisulfate Debrisoquine hemisulfate; Isocaramidine hemisulfate; Ro 5-3307/1 hemisulfate	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Endogenous metabolite Isoquinoline Alkaloids Disease Research Fields	Endogenous Metabolite
Debrisoquin (Isocaramidine) hemisulfate is a TMPRSS2 inhibitors that inhibits *SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC₅₀* of 22μM. Debrisoquin hemisulfate can be used for antiviral research .

HY-13512

Camostat mesylate 30+ Cited Publications Camostat mesilate; FOY305; FOY-S980	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Ser/Thr Protease SARS-CoV
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against *SARS-CoV-2*. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-N8306

Isojacareubin	Structural Classification Flavonoids Flavones Source classification Guttiferae Plants Hypericum japonicum Thunb. ex Murray	Bacterial PKC Apoptosis SARS-CoV
Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits *SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis* .

HY-18234A

Leupeptin hemisulfate 35+ Cited Publications	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Cathepsin Ser/Thr Protease Virus Protease
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main protease of *SARS-CoV-2*) and also has anti-inflammatory activity .

HY-N10109A

Gallinamide A TFA	Structural Classification Natural Products Microorganisms Source classification	SARS-CoV Parasite Cathepsin
Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC₅₀: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC₅₀: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC₅₀: 50 nM) .

HY-N0360R

Dihydrotanshinone I (Standard)	Quinones Structural Classification Labiatae Samanea saman (Jacq.) Merr. Source classification Plants Phenanthrenequinones	SARS-CoV
Dihydrotanshinone I (Standard) is the analytical standard of Dihydrotanshinone I. This product is intended for research and analytical applications. Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

HY-N1996

Chebulagic acid 4 Publications Verification	Structural Classification Classification of Application Fields Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants Inflammation/Immunology Disease Research Fields	COX Lipoxygenase SARS-CoV Influenza Virus
Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against *SARS-CoV-2* viral replication with an EC₅₀ of 9.76 μM.

HY-N9351

Cleistanthin B Diphyllin O-glucoside	Cardiovascular Disease Infection other families Classification of Application Fields Source classification Lignans Metabolic Disease Phenylpropanoids Plants Disease Research Fields	SARS-CoV
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC₅₀ of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo .

HY-W012531R

2-Hydroxycinnamic acid (Standard)	Structural Classification Monophenols Cinnamomum cassia (L.) D. Don Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Lauraceae	HIV SARS-CoV Endogenous Metabolite
2-Hydroxycinnamic acid (Standard) is the analytical standard of 2-Hydroxycinnamic acid. This product is intended for research and analytical applications. 2-Hydroxycinnamic acid is isolated from the methanol extract of Cinnamomum cassia. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC₅₀ of 0.3 mM

HY-N12697A

Polycarpine hydrochloride	Structural Classification Alkaloids Animals Other Alkaloids Source classification	SARS-CoV Virus Protease Influenza Virus Fungal
Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC₅₀ = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC₅₀ values of 30.0 nM and 0.12 μM against *SARS-CoV-2 Mpro* and PEDV Mpro, respectively .

HY-B1028

Pantethine 1 Publications Verification D-Pantethine; LBF disulfide	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite SARS-CoV
Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-N2355

Solasurine	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Solanum surattense Burm. F. Source classification Other Diseases Plants Solanaceae Disease Research Fields	SARS-CoV
Solasurine is a steroidal alkaloid that can be isolated from Solanum surrattence. Solasurine can interact with the C3-like protease (SARS-CoV-2 main protease) amino acids Phe8, Pro9, Ile152, Tyr154, Pro293, Phe294, Val297, and Arg298 .

HY-16050

Plitidepsin 2 Publications Verification Aplidine; PM90001	Structural Classification Microorganisms Marine natural products Source classification Other marine organisms	DNA/RNA Synthesis SARS-CoV
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against *SARS-CoV-2* with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

HY-13512R

Camostat mesylate (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Ser/Thr Protease SARS-CoV
Camostat (mesylate) (Standard) is the analytical standard of Camostat (mesylate). This product is intended for research and analytical applications. Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against *SARS-CoV-2*. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-N7073

Silymarin 5 Publications Verification	Infection Structural Classification Natural Products Glycine soya Neurological Disease Classification of Application Fields Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Inflammation/Immunology Disease Research Fields	SARS-CoV
Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective *SARS-CoV-2 main protease (M ^pro)* inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research .

HY-107577

Gedunin	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	HSP
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research .

HY-126419

Kobophenol A	Infection Classification of Application Fields Source classification Cyperaceae Phenols Polyphenols Plants Disease Research Fields Carex kobomugi Ohwi	SARS-CoV PKC
Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC₅₀ of 1.81 μM and inhibits *SARS-CoV-2* viral infection in cells with an EC₅₀ of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC₅₀ of 52 µM .

HY-17367

Atazanavir 10+ Cited Publications BMS-232632	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a *SARS-CoV* 3CL ^pro inhibitor with an IC₅₀** of 3.49 μM .

HY-17367A

Atazanavir sulfate 10+ Cited Publications BMS-232632 sulfate	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a *SARS-CoV* 3CL ^pro inhibitor with an IC₅₀** of 3.49 μM .

HY-N0063

Punicalagin 5+ Cited Publications	Infection Structural Classification Punica granatum L. Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Punicaceae Plants Disease Research Fields	SARS-CoV HBV
Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CL ^pro inhibitor and inhibits *SARS-CoV-2* replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .

HY-N1996R

Chebulagic acid (Standard)	Structural Classification Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants	COX Lipoxygenase SARS-CoV Influenza Virus
Chebulagic acid (Standard) is the analytical standard of Chebulagic acid. This product is intended for research and analytical applications. Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC₅₀ of 9.76 μM.

HY-110066

(Z)-Guggulsterone 3 Publications Verification	Structural Classification Classification of Application Fields Commiphora myrrha (Nees) Engl. Source classification Plants Burseraceae Disease Research Fields Steroids Cancer	Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR
(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and *SARS-CoV-2* infection .

HY-B0157A

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against *SARS-CoV-2* and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-B0157

Ketotifen 3 Publications Verification HC 20-511	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against *SARS-CoV-2* and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

Cat. No.	Product Name	Chemical Structure

HY-135853S

Molnupiravir-d7

Molnupiravir-d₇ is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza[1][2].

HY-104077S

Remdesivir-d5 2 Publications Verification
Remdesivir-d₅ is a deuterium labeled Remdesivir. Remdesivir (GS-5734) is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of 2019-nCoV (COVID-19) infection in vitro[1][2].

HY-15463S2

Imatinib-d3 hydrochloride

Imatinib-d₃ (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.

HY-90001S

Ritonavir-d6
Ritonavir-d₆ is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM[1][2].

HY-104077S1

Remdesivir-d4
Remdesivir-d₄ is deuterium labeled Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

HY-104077S2

Remdesivir impurity 9-d4
Remdesivir impurity 9-d₄ is deuterium labeled Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

HY-P5168S

GPSVFPLAPSSK-13C6
GPSVFPLAPSSK- ¹³C₆ is the ¹³C labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].

HY-17007S

Saquinavir-d9
Saquinavir-d₉ is the deuterium labeled Saquinavir. Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM[1][2].

HY-W653853

Ritonavir-13C3
Ritonavir- ¹³C₃ is ¹³C labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a *SARS-CoV* 3CL ^pro inhibitor with an IC₅₀** of 1.61 μM .

HY-90001S2

Ritonavir-d8
Ritonavir-d₈ is deuterated labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a *SARS-CoV* 3CL ^pro inhibitor with an IC₅₀** of 1.61 μM.

HY-90001S1

Ritonavir-13C,d3
Ritonavir- ¹³C,d₃ is the ¹³C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.

HY-17430S1

Amprenavir-d4-1
Amprenavir-d₄-1 is deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.

HY-17430S

Amprenavir-d4
Amprenavir-d₄ is the deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM[1][2].

HY-B0462AS

Azelastine-13C,d3
Azelastine- ¹³C,d₃ is deuterium labeled Azelastine. Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].

HY-145119S

Mindeudesivir
GS-621763-d₁ is the deuterium labeled GS-621763 (HY-145119) . GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against *SARS-CoV-2* pathogenesis in mice .

HY-B0190S1

Nafamostat formate salt-13C6
Nafamostat formate salt- ¹³C₆ is the ¹³C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .

HY-W031727S

Hydroxychloroquine-d4-1 sulfate
Hydroxychloroquine-d₄-1 (sulfate) is the deuterium labeled Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-W031727S1

Hydroxychloroquine-d5
Hydroxychloroquine-d₅ is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

HY-169220S

RORγ/DHODH-IN-1
RORγ/DHODH-IN-1 (compound 1404), a deuterium labeled compound, is a dual RORγ and DHODH inhibitor with IC₅₀ values of 9.7 nM and 100 nM, repaectively. RORγ/DHODH-IN-1 blocks the replication of *SARS-CoV-2, HCMV, and non-enveloped DNA virus (HAdV5)* .

HY-B1370S

Hydroxychloroquine-d4 sulfate
Hydroxychloroquine-d₄ (sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-15602S

Ledipasvir-d6
Ledipasvir-d₆ is the deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM[3].

HY-B0372AS

Bromhexine-d3 hydrochloride

Bromhexine-d₃ (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions[1][2][3][4].

HY-100442S

Paquinimod-d5
Paquinimod-d5 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-90001S3

rel-Ritonavir-d6
rel-Ritonavir-d₆ (rel-ABT 538-d₆; rel-RTV-d₆) is the deuterium labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a *SARS-CoV* 3CLpro inhibitor with an IC₅₀** of 1.61 μM .

HY-100442S1

Paquinimod-d5-1
Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-10237S

Boceprevir-d9
Boceprevir-d₉ is the deuterium labeled Boceprevir. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay[1][2][3][4][5]. Boceprevir inhibits SARS-CoV-2 3CLpro activity[6].

HY-17589AS

Chloroquine-d5 1 Publications Verification
Chloroquine-d₅ is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589S1

Chloroquine-d4 phosphate

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589S

Chloroquine-d5 diphosphate

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-14904AS

Umifenovir-d6 hydrochloride

Umifenovir-d₆ (hydrochloride) is the deuterium labeled Umifenovir hydrochloride. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3].

HY-B0462S

Azelastine-13C,d3 hydrochloride
Azelastine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Azelastine hydrochloride. Azelastine- ¹³C,d₃ (hydrochloride), an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine- ¹³C,d₃ (hydrochloride) can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].

HY-169222S

RORγ/DHODH-IN-2
RORγ/DHODH-IN-2 (Compound 1311) is an orally active dual inhibitor of RORγ/DHODH with IC₅₀ values of 11.9 nM and 90 nM, respectively. RORγ/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC₅₀ values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively .

HY-145119AS

Mindeudesivir hydrobromide
Mindeudesivir (JT001; VV116; GS-621763-d₁) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against *SARS-CoV-2* and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 .

HY-B1028S

Pantethine-15N2

Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-15148S1

Tipranavir-d7
Tipranavir-d₇ is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

HY-17367S3

Atazanavir-d5
Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S2

Atazanavir-d9
Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-10235S

Telaprevir-d4
Telaprevir-d₄ is the deuterium labeled Telaprevir. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide[1][2][3]. Telaprevir inhibits SARS-CoV-2 3CLpro activity[4].

HY-14588S2

Lopinavir-d7

Lopinavir-d₇ is deuterated labeled Lopinavir (HY-14588). Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-14588S1

Lopinavir-d8
Lopinavir-d₈ (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[1][2]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[3].

HY-119980S

Fluphenazine-d8

Fluphenazine-d₈ is the deuterium labeled Fluphenazine. Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-14588S

(rel)-Lopinavir-d8

(rel)-Lopinavir-d₈ ((rel)-ABT-378-d₈)is the deuterium labeledLopinavir(HY-14588) . Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-14393S

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

HY-113478S

Ursodeoxycholic acid-2,2,4,4-d4

Ursodeoxycholic acid-2,2,4,4-d₄ is the deuterium labeled Ursodeoxycholic acid (HY-13771). Ursodeoxycholic acid is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection[1][2][3][4][5].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks