2. Signaling Pathways
  3. Immunology/Inflammation
  4. COX

COX

COX

Cyclooxygenase

COX

Related Products

PDF 4.89 MB

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX Isoform Specific Products:

COX Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15037
    Diclofenac Sodium
    		Inhibitor 99.94%
    Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
    Diclofenac Sodium
  • HY-N0416
    Cucurbitacin B
    		Inhibitor 99.81%
    Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity.
    Cucurbitacin B
  • HY-B1227
    Carprofen
    		Inhibitor 99.83%
    Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.
    Carprofen
  • HY-B0167
    Salicylic acid
    		Inhibitor 98.42%
    Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.
    Salicylic acid
  • HY-N0889
    Ginkgetin
    		99.86%
    Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ.
    Ginkgetin
  • HY-13913
    NS-398
    		Inhibitor 99.72%
    NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
    NS-398
  • HY-N1067
    Xanthohumol
    		Inhibitor 99.97%
    Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).
    Xanthohumol
  • HY-N0256
    Hederagenin
    		Inhibitor 99.95%
    Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury.
    Hederagenin
  • HY-B1221
    Flufenamic acid
    		Inhibitor 99.93%
    Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
    Flufenamic acid
  • HY-B0360
    Rebamipide
    		Activator 99.98%
    Rebamipide (OPC12759) is an orally active gastroprotective agent that enhances the production of endogenous PGs (especially intragastric PGE2) by inducing COX-2 expression, thereby protecting the gastric mucosa from injury. Rebamipide exerts anti-proliferative activity against gastric cancer cells. Rebamipide can be used in studies of mucosal protection, gastroduodenal ulcer, gastritis and gastric cancer.
    Rebamipide
  • HY-N0002
    (-)-Epicatechin gallate
    		Inhibitor 98.57%
    (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.
    (-)-Epicatechin gallate
  • HY-B0476
    Phenacetin
    		Inhibitor 99.94%
    Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats.
    Phenacetin
  • HY-14654R
    Aspirin (Standard)
    		Inhibitor 99.85%
    Aspirin (Standard) is the analytical standard of Aspirin. This product is intended for research and analytical applications. Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
    Aspirin (Standard)
  • HY-B0227
    Ketoprofen
    		Inhibitor 99.95%
    Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity.
    Ketoprofen
  • HY-78131A
    (S)-(+)-Ibuprofen
    		Inhibitor 99.98%
    (S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects.
    (S)-(+)-Ibuprofen
  • HY-16343
    NB-598
    		Inhibitor 98.69%
    NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NB-598
  • HY-101840A
    EIPA hydrochloride
    		Inhibitor 98.31%
    EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.
    EIPA hydrochloride
  • HY-N0022
    Isoacteoside
    		Inhibitor 99.73%
    Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities.
    Isoacteoside
  • HY-17009
    Iguratimod
    		Inhibitor 98.49%
    Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
    Iguratimod
  • HY-59105
    SC-560
    		Inhibitor 99.79%
    SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM.
    SC-560
Cat. No. Product Name / Synonyms Application Reactivity
COX Isoform Comparison

COX

COX-1

COX-2

COX-3

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

COX Inhibitors, Activators & Modulators
Product NameCOXCOX-1COX-2COX-3Purity    
Acetaminophen 
COX-1, IC50: 113.7 μM
COX-2, IC50: 25.8 μM
 99.98%
Indomethacin 
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
 99.91%
EIPA  
COX-2
 99.73%
Celecoxib 
COX-1, IC50: 15 μM
COX-2, IC50: 40 nM
 99.89%
Aspirin 
COX-1, IC50: 27.75 μM
COX-2, IC50: 1.17 mM
 99.90%
Oxidopamine hydrobromide  
COX-2
 99.95%
Oxidopamine hydrochloride  
COX-2
 99.91%
Gallic acid  
COX-2
 99.99%
Diclofenac 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 99.92%
Ibuprofen 
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
 99.97%
Catechin 
COX-1, IC50: 1.4 μM
  99.57%
20(S)-Ginsenoside Rg3  
COX-2
 99.94%
(-)-Epicatechin 
COX-1, IC50: 3.2 μM
  99.00%
Meloxicam 
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
 99.59%
Naproxen 
COX-1, IC50: 9.55 μM
COX-2, IC50: 5.65 μM
 99.98%
Diclofenac Sodium 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 99.94%
Carprofen 
COX-1, IC50: 22.3 μM
COX-2, IC50: 3.9 μM
 99.83%
Salicylic acid  
COX-2
 98.42%
NS-398  
COX-2, IC50: 3.8 μM
 99.72%
Xanthohumol 
COX-1
COX-2
 99.97%
Rebamipide  
COX-2
 99.98%
(-)-Epicatechin gallate 
COX-1, IC50: 7.5 μM
  98.57%
Phenacetin   
COX-3, IC50: 102 μM
99.94%
Aspirin (Standard) 
COX-1
COX-2
 99.85%
Ketoprofen 
COX-1, IC50: 2 nM (in human blood monocytes)
COX-2, IC50: 26 nM (in human blood monocytes)
 99.95%
(S)-(+)-Ibuprofen 
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
 99.98%
EIPA hydrochloride  
COX-2
 98.31%
Iguratimod  
COX-2, IC50: 20 μM
 98.49%
SC-560 
COX-1, IC50: 9 nM
COX-2, IC50: 6.3 μM
 99.79%
Isoorientin  
COX-2, IC50: 39 μM
 99.26%
Ginsenoside C-K  
COX-2
 99.92%
Valdecoxib 
COX-1, IC50: 140 μM
COX-2, IC50: 5 nM
 99.90%
Neochlorogenic acid  
COX-2
 99.77%
Sodium Salicylate  
COX-2
 99.93%
Parecoxib  
COX-2
 99.29%
Piroxicam 
COX-1, IC50: 47 μM (in human monocytes)
COX-2, IC50: 25 μM (in human monocytes)
 99.71%
Guaiacol  
COX-2
 99.95%
Harpagoside 
COX-1
COX-2
 99.88%
Mefenamic acid 
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 μM
 99.95%
Niflumic acid  
COX-2, IC50: 100 nM
 99.88%
Nimesulide  
COX-2, IC50: 0.07-70 μM
 99.90%
Rutaecarpine 
COX-1, IC50: 8.7 μM (in BMMC)
COX-2, IC50: 0.28 μM (in BMMC)
 99.09%
Ginsenoside Rd  
COX-2
 99.88%
Psoralidin  
COX-2
 99.90%
Ibuprofen sodium 
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
 99.98%
Prim-O-glucosylcimifugin  
COX-2
 99.94%
Fenofibric acid  
COX-2, IC50: 48 μM
 99.94%
Flurbiprofen
COX
COX-1
COX-2
 99.98%
Rofecoxib  
Human COX-2, IC50: 18 nM (in Chinese hamster ovary cells)
Human COX-2, IC50: 26 nM (in human osteosarcoma cells)
 99.84%
Salicin
COX
   99.77%
Ginsenoside Rg5  
COX-2
 99.87%
Etoricoxib 
COX-1, IC50: 116 μM (in human whole blood)
COX-2, IC50: 1.1 μM (in human whole blood)
 99.90%
Gamma-Mangostin  
COX-2
 99.91%
Paradol  
COX-2
 99.42%
Diflunisal
COX
   99.93%
Broussonin E  
COX-2
 98.18%
Ethyl Caffeate  
COX-2
 98.06%
cis-5-Dodecenoic acid 
COX-1
COX-2
 99.76%
Roburic acid 
COX-1, IC50: 5 μM
COX-2, IC50: 9 μM
 ≥98.0%
Cafestol  
COX-2
 99.91%
γ-Tocopherol
Cyclooxygenase
   99.63%
Isofraxidin  
COX-2
 99.00%
Dihydrokavain 
COX-1
COX-2
 99.94%
Lumiracoxib 
COX-1, Ki: 3 μM
COX-2, Ki: 0.06 μM
 99.65%
Licofelone
COX, IC50: 0.21 μM
   99.84%
Madecassic acid  
COX-2
 99.81%
Imrecoxib 
Human COX-1, IC50: 115 nM
Human COX-2, IC50: 18 nM
 99.48%
Pectolinarigenin  
COX-2
 99.79%
Tolfenamic Acid  
COX-2, IC50: 13.49 μM (in cell)
 99.94%
Avicularin  
COX-2
 99.80%
α-Humulene  
COX-2
 98.53%
S-(+)-Ketoprofen 
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
 99.88%
Indobufen
COX
   99.98%
Syringaldehyde  
COX-2, IC50: 19.2 μM
 99.96%
[10]-Shogaol  
COX-2, IC50: 7.5 μM
 99.88%
Ketorolac 
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 99.93%
SC-236 
COX-1, IC50: 17.8 μM
COX-2, IC50: 10 nM
 99.56%
Nabumetone  
COX-2
 99.90%
Dendrophenol  
COX-2
 99.93%
Ampiroxicam
COX
   98.43%
Etodolac 
COX-1, IC50: ∼50000 nM (in CHO cells)
COX-2, IC50: 41 nM (in CHO cells)
 99.77%
Lornoxicam 
COX-1, IC50: 5 nM (in cells)
COX-2, IC50: 45 nM (in cells)
 99.36%
Oxaprozin 
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
 99.95%
[8]-Shogaol  
COX-2, IC50: 17.5 μM
 99.93%
Bromfenac sodium 
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
 98.52%
Naproxen sodium 
COX-1, IC50: 9.55 μM (in intact cells )
COX-2, IC50: 5.65 μM (in intact cells )
 99.87%
Jaceosidin  
COX-2
 99.51%
Fenoprofen Calcium hydrate
COX
   99.69%
NF-κB/MAPK-IN-1  
COX-2
 98.42%
3,3'-Diiodo-L-thyronine
COX
   
Deracoxib  
COX-2
 99.65%
FK 3311  
COX-2
 98.04%
Pranoprofen 
COX-1
COX-2
 98.65%
(-)-Catechin gallate 
COX-1
COX-2
 99.98%
Ketorolac tromethamine salt 
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 99.91%
(S)-Flurbiprofen 
COX-1, IC50: 0.48 μM
COX-2, IC50: 0.47 μM
 99.89%
S-(+)-Marmesin  
COX-2
 99.04%
Ufenamate  
COX-2
 99.89%
Gnetol 
COX-1, IC50: 0.78 μM
  99.86%
Parecoxib Sodium  
COX-2
 99.94%
α-Spinasterol 
COX-1, IC50: 16.17 μM
COX-2, IC50: 7.76 μM
 99.15%
Salicylic acid-d6  
COX-2
 99.32%
N-tert-Butyl-α-phenylnitrone  
COX-2
 99.94%
Hexahydrocurcumin  
COX-2
 99.88%
AG-024322 
COX-1, Ki: 2.3 nM
COX-2, Ki: 3 nM
 98.53%
(E)-Ethyl p-methoxycinnamate 
COX-1, IC50: 1.12 μM
COX-2, IC50: 0.83 μM
 99.53%
Macelignan  
COX-2
 99.95%
Ginsenoside Rb3  
COX-2
 99.12%
Tolmetin 
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 99.82%
Inulicin  
COX-2
 99.94%
β-Elemonic acid  
COX-2
 99.90%
DuP-697 
hCOX-1, IC50: 800 nM
hCOX-2, IC50: 10 nM
 99.67%
Terameprocol  
COX-2
 99.33%
Fenbufen 
COX-1, IC50: 3.9 μM
COX-2, IC50: 8.1 μM
 99.33%
Humulone  
COX-2
 99.46%
Tenidap 
COX-1, IC50: 0.03 μM
COX-2, IC50: 1.2 μM
 99.32%
Zaltoprofen 
COX-1, IC50: 1.3 μM
COX-2, IC50: 0.34 μM
 99.28%
Tenoxicam 
COX-1
COX-2
 99.93%
Nepafenac 
COX-1, IC50: 64.3 μM
  99.51%
Triflusal  
COX-2, IC50: 280 μM
COX-2, IC50: 160 μM (in human blood)
 99.83%
Asaraldehyde  
COX-2
 99.83%
Acemetacin 
COX-1, IC50: 85 μM (in human intact cell)
  99.97%
PTUPB 
COX-1, IC50: 100 μM
COX-2, IC50: 1.26 μM
 98.69%
Loxoprofen sodium 
COX-1, IC50: 6.5 μM
COX-2, IC50: 13.5 μM
 99.98%
Loxoprofen 
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
 99.80%
Moracin C  
COX-2
 99.54%
Felbinac 
COX-1, IC50: 865.68 nM
COX-2, IC50: 976 nM
 99.74%
TFAP 
COX-1, IC50: 0.8 μM
  99.98%
Ampyrone
COX
   99.72%
Aceclofenac 
COX-1, IC50: 7.3 μM
COX-2, IC50: 3 μM
 99.91%
Diclofenac potassium 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 nM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 nM
 99.99%
Adelmidrol  
COX-2
 ≥98.0%
CAY10404 
COX-1, IC50: >500 μM
COX-2, IC50: 1 nM
 99.69%
Eicosatetraynoic acid
COX, ID50: 8 μM
   ≥99.0%
Gallic acid hydrate  
COX-2
 99.81%
Tilmicosin phosphate  
COX-2
 ≥98.0%
7,3',4'-Tri-O-methylluteolin  
COX-2
 99.28%
Ketorolac-d5 
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 98.31%
Phenacetin (Standard)   
COX-3
99.97%
SC-58125 
hCOX-1, IC50: >100 μM
hCOX-2, IC50: 0.04 μM
 99.92%
Phenidone
COX
   99.00%
Firocoxib 
COX-1, IC50: 7.5 μM
COX-2, IC50: 0.13 μM
 99.54%
Diclofenac diethylamine 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 99.96%
Flunixin meglumine 
COX-1, IC50: 0.55 μM
COX-2, IC50: 3.24 μM
 99.71%
2,5-Di-tert-butylhydroquinone  
COX-2, IC50: 14.1 μM
 99.90%
Amfenac Sodium Hydrate  
COX-2
 99.07%
Alminoprofen  
COX-2
 99.91%
Mofezolac 
COX-1, IC50: 1.44 nM
COX-2, IC50: 447 nM
 99.34%
Salicylic acid (Standard)  
COX-2
 
FR122047 
COX-1, IC50: 28 nM
  99.55%
Phenethyl ferulate
COX, IC50: 4.35 μM
   99.88%
(+)-Catechin hydrate 
COX-1, IC50: 1.4 μM
  99.59%
Columbin 
COX-1, EC50: 327 μM
COX-2, EC50: 53.1 μM
 99.86%
Byakangelicol  
COX-2
 99.87%
Timosaponin A1  
COX-2, IC50: 36.43 μM
 99.70%
Propyphenazone
COX
   99.85%
Hydrangenol  
COX-2
 99.63%
β-Amyrone  
COX-2
 99.87%
Peonidin chloride  
COX-2
 98.70%
Valeryl salicylate 
COX-1
  ≥99.0%
α-​Chaconine  
COX-2
 99.04%
Sphondin  
COX-2
 99.70%
Bromfenac sodium hydrate 
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
 99.94%
Phenyl β-D-glucopyranoside  
COX-2
 99.85%
Flurbiprofen axetil
COX
   99.85%
Fenofibric acid (Standard)  
COX-2
 99.16%
Acetaminophen (Standard) 
COX-1
COX-2
 99.94%
Enflicoxib  
COX-2
 99.90%
Polmacoxib  
COX-2, IC50: 0.1 μg/mL
 99.70%
Mavacoxib  
COX-2
 99.04%
Otenaproxesul 
COX-1
COX-2
 98.03%
Isoxicam 
COX-1
COX-2
 99.83%
Pelubiprofen  
COX-2
 99.27%
Lupeol acetate  
COX-2
 ≥98.0%
Iminostilbene  
COX-2
 99.34%
BW 755C 
COX-1, IC50: 0.65 μg/mL
COX-2, IC50: 1.2 μg/mL
 
Tolmetin sodium dihydrate 
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 99.94%
Nitroflurbiprofen
COX
   99.64%
Vedaprofen 
COX-1
  99.81%
Tebufelone  
COX-2
 99.52%
Teriflunomide impurity 3 
COX-1, IC50: 30 μM
  99.75%
(-)-Epicatechin gallate (Standard) 
COX-1
  
Nitroaspirin 
COX-1
  
Indomethacin-d4 
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
 99.78%
Indazole-Cl  
COX-2
 98.72%
ARN14494  
COX-2
 99.08%
Desmethyl Celecoxib  
COX-2, IC50: 32 nM
 99.42%
Pamicogrel
Cyclooxygenase
   99.44%
Floctafenine 
COX-1
COX-2
 
GW-406381  
COX-2
 99.69%
(-)-Epicatechin (Standard) 
COX-1
  
Anemarsaponin B  
COX-2
 
Hamaudol 
COX-1, IC50: 0.3 mM
COX-2, IC50: 0.57 mM
 99.59%
Cimicoxib  
COX-2
 98.02%
Madecassic acid (Standard)  
COX-2
 
3,9-Dihydroeucomin  
COX-2
 
SC57666  
COX-2, IC50: 26 nM
 98.94%
FR-188582  
COX-2, IC50: 17 nM
 99.12%
Plantanone B 
Ovine COX-1, IC50: 21.78±0.2 μM
Ovine COX-2, IC50: 44.01±0.42 μM
 99.16%
RWJ 63556  
COX-2
 99.35%
Ketoprofen (lysinate) 
COX-1, IC50: 2 nM
COX-2, IC50: 26 nM
 
COX-2-IN-6  
COX-2
 98.80%
Aspirin lithium 
COX-1
COX-2
 
Ocarocoxib  
COX-2
 99.94%
Indomethacin sodium 
COX-1, IC50: 18 nM
COX-2, IC50: 26 nM
 
COX-2-IN-28 
COX-1, IC50: 13.21 μM
COX-2, IC50: 0.054 μM
 
Tolmetin sodium 
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 
Jaceosidin (Standard)  
COX-2
 
Daturaolone 
COX-1
  
Antitumor agent-77  
COX-2
 
COX-1-IN-1 
COX-1, IC50: 0.23 μM
COX-2, IC50: 50 μM
 
COX-2/LOX-IN-1  
COX-2, IC50: 0.55 μM
 
COX-1/2-IN-2 
COX-1, IC50: 9.7±0.09 μM
COX-2, IC50: 4.6±1.45 μM
 
Topo I/COX-2-IN-2  
COX-2, IC50: 2.31 μM
 
TX-1123 
COX-1, IC50: 15.7 μM
COX-2, IC50: 1.16 nM
 
COX-2-IN-21 
COX-1, IC50: 12.4 μM
COX-2, IC50: 0.039 μM
 
Longiferone B  
COX-2
 
COX-2-IN-27 
COX-1, IC50: 13.22 μM
COX-2, IC50: 0.045 μM
 
LM-4108 
Ovine COX-1, IC50: >66 μM
Human COX-2, IC50: 60 nM
 
STAT1/3-IN-1  
COX-2
 
COX-2-IN-5  
COX-2, IC50: 0.65 μM
 
Ginsenoside Rb3 (Standard)  
COX-2
 
COX-2-IN-17 
COX-1, IC50: >10 μM
COX-2, IC50: 0.02 μM
 
VI-60  
COX-2
 
Ginsenoside C-K (Standard)  
COX-2
 
COX-2/15-LOX-IN-6  
COX-2, IC50: 0.201 μM
 
Antitumor agent-78  
COX-2
 
COX-2-IN-51  
COX-2, IC50: 70.7 nM
 
LY256548
Cyclooxygenase
   
Ginsenoside Rd (Standard)  
COX-2
 
Heterophdoid A  
COX-2
 
COX-2-IN-47  
COX-2, IC50: 0.03 μM
 
iNOS/COX-2-IN-1  
COX-2
 
COX-1/2-IN-1 
COX-1, IC50: 9.7±0.09 μM
COX-2, IC50: 4.6±1.45 μM
 
COX-2-IN-46  
COX-2, IC50: 87.74 nM
 
COX-2-IN-31 
COX-1, IC50: 12.5 μM
COX-2, IC50: 60 nM
 
COX-2-IN-10  
COX-2
 
Clematomandshurica saponin B  
COX-2
 
Kadsulignan N  
COX-2
 
COX-2/sEH-IN-1 
COX-1, IC50: 8.72 μM
COX-2, IC50: 1.24 μM
 
Meloxicam sodium 
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
 
COX-2-IN-48  
Human COX-2, IC50: 51.7 nM
 
COX-2-IN-30 
COX-1, IC50: 10.4 μM
COX-2, IC50: 49 nM
 
(S)-(+)-Ibuprofen-d3 
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
 98.87%
Oxaprozin potassium 
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
 
Taraxerol acetate 
COX-1, IC50: 116.3 μM
COX-2, IC50: 94.7 μM
 
COX-2-IN-16  
COX-2, IC50: 102 μM
 
EGFR/COX-2-IN-1 
COX-1, IC50: 20.1 μM
COX-2, IC50: 1.52 μM
 
COX-2-IN-14  
COX-2
 
Ermanin  
COX-2
 
COX-1/2-IN-3 
COX-1
COX-2
 
COX-2/PI3K-IN-2  
COX-2, Ki: 3.02 nM
 
Lucidone  
COX-2
 
COX-2-IN-35  
COX-2, IC50: 4.37 nM
 
COX-1/2-IN-8 
COX-1, IC50: 2.14 ± 0.0 μM
COX-2, IC50: 0.58 ± 0.0 μM
 
Pifoxime 
COX-1
COX-2
 
COX-2-IN-32  
COX-2
 
WYZ90 
COX-1, IC50: 5734 nM
COX-2, IC50: 75 nM
 
Bromfenac 
Human COX-1, IC50: 5.56 nM
Human COX-2, IC50: 7.45 nM
 
Loxoprofen sodium (dihydrate) 
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
 
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone 
COX-1
COX-2
 99.64%
COX-1-IN-2 
COX-1, IC50: 38.76 nM
  
COX-2-IN-19 
COX-1, IC50: 117.8 μM
COX-2, IC50: 1.76 μM
 
COX-2-IN-52 
COX-1, IC50: 15.98 μM
COX-2, IC50: 54 nM
 
COX-2/15-LOX-IN-1 
COX-1, IC50: 10.65 μM
COX-2, IC50: 0.075 μM
 
COX-2-IN-34  
COX-2, IC50: 0.42 μM
 98.87%
Anti-inflammatory agent 78 
COX-1
COX-2
 
COX-2-IN-40  
COX-2, IC50: 14.86 μM
 
COX-2-IN-29 
COX-1, IC50: > 10 μM
COX-2, IC50: 0.005 μM
 
Mefenamic acid-d4 
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 nM
 ≥98.0%
COX-2-IN-42  
COX-2
 
(±)-Aiphanol 
COX-1, IC50: 1.9 μM
COX-2, IC50: 9.9 μM
 
Balanophonin  
COX-2
 
BMP-4  
COX-2
 
COX-2-IN-23 
COX-1, IC50: 20.14 μM
COX-2, IC50: 0.28 μM
 
Anti-inflammatory agent 20  
COX-2
 
Shizukaol B  
COX-2
 
COX-2-IN-20 
COX-1, IC50: 19.3 μM
COX-2, IC50: 17.9 nM
 
Flunixin 
COX-1, IC50: 0.55 μM
COX-2, IC50: 3.24 μM
 
COX-2-IN-22  
COX-2, IC50: 8.6 μM
 
COX-2/NLRP3-IN-1  
COX-2, IC50: 1.53 μM
 
COX-2-IN-43 
COX-1, IC50: 0.983 μM
COX-2, IC50: 0.247 μM
 
MCI  
COX-2, IC50: 1.23 μM
 
Axinelline A 
COX-1, IC50: 8.89 μM
COX-2, IC50: 2.22 μM
 
L 748780 
COX-1, IC50: > 100 μM
COX-2, IC50: 0.5 μM
 
COX-2-IN-26 
COX-1, IC50: 10.61 μM
COX-2, IC50: 0.067 μM
 
20(S)-Ginsenoside Rg3 (Standard)  
COX-2
 
Anti-inflammatory agent 56  
COX-2
 
LY 178002
Cyclooxygenase
   
15-LOX-IN-2 
COX-1, IC50: 7.510 μM
COX-2, IC50: 0.190 μM
 
COX-2/PI3K-IN-1  
COX-2, Ki: 3.24 nM
 
Timegadine
COX, IC50: 5 nM (in rabbit platelets)
COX, IC50: 20 μM (in rat brain)
   
Eltenac 
COX-1, IC50: 0.03 μM
COX-2, IC50: 0.03 μM
 
Cudraflavone B 
COX-1
COX-2
 
AChE-IN-82 
COX-1, IC50: 60.41 μM
COX-2, IC50: 0.187 μM
 
Akt/NF-κB/MAPK-IN-1  
COX-2
 
Nimesulide-d5  
COX-2, IC50: 0.07-70 μM
 
COX-2-IN-49  
COX-2, IC50: 2.671 μM
 
PYZ18  
COX-2, IC50: 7.07 μM
 
Avicularin (Standard)  
COX-2
 
COX-2-IN-44 
COX-1, IC50: 1.14 μM
COX-2, IC50: 0.18 μM
 
COX-2-IN-24  
COX-2, IC50: 0.17 μM
 
COX-2/5-LOX-IN-3 
COX-1, IC50: 45.73 μM
COX-2, IC50: 5.45 μM
 
Akt/NF-κB/JNK-IN-1  
COX-2
 
NCX 466 
COX-1
COX-2
 
Indomethacin N-octyl amide 
COX-1, IC50: 66 μM
COX-2, IC50: 0.04 μM
 
BF389 
COX-1, IC50: 4 μg/mL
COX-2, IC50: 8 μg/mL
 
Fenoprofen Calcium
COX
   
COX-1/2-IN-9 
COX-1, IC50: 0.031 μM
COX-2, IC50: 0.010 μM
 
Multinoside A  
COX-2
 
Tenidap sodium 
COX-1
COX-2
 
4-Desmethyl-2-methyl celecoxib  
COX-2, IC50: 0.069 μM
 
LFS-1107  
COX-2
 
ZLJ-6 
COX-1, IC50: 0.73 μM
COX-2, IC50: 0.31 μM
 
Flosulide  
COX-2
 
Thioflosulide  
COX-2, IC50: 2.3 nM
 
S-2474 
COX-1, IC50: 27 μM
COX-2, IC50: 11 nM
 
Catechin hydrate 
COX-1, IC50: 1.4 μM
  
N1-Acetyl-5-methoxykynuramine hydrochloride  
COX-2
 
COX-2-IN-1  
COX-2, IC50: 3.9 μM
 
COX-2-IN-2  
COX-2, IC50: 240 nM
 99.53%
Tilmacoxib  
Human COX-2, IC50: 85 nM
 ≥99.0%
COX/5-LO-IN-1
COX
   
SC58451  
COX-2