2. Signaling Pathways
  3. Immunology/Inflammation
  4. COX

COX

COX

Cyclooxygenase

COX

Related Products

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Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX Isoform Specific Products:

COX Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-105028R
    Tenidap (Standard)
    		Inhibitor
    Tenidap (Standard) is the analytical standard of Tenidap. This product is intended for research and analytical applications. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor.
    Tenidap (Standard)
  • HY-N8012
    Multinoside A
    		Inhibitor
    Multinoside A (compound 6) is an antioxidant with DPPH free radical scavenging activity (IC50=54.3 μg/mL). Multinoside A can also downregulate COX-2 expression (IC50=9.6 μg/mL) and inhibit NO production (IC50=43.9 μg/mL).
    Multinoside A
  • HY-W703540
    Deracoxib-d4
    		Inhibitor
    Deracoxib-d4 (SC 046-d4) is deuterium labeled Deracoxib.
    Deracoxib-d<sub>4</sub>
  • HY-105028A
    Tenidap sodium
    		Inhibitor
    Tenidap is a non-steroidal anti-inflammatory active molecule and a selective inhibitor of COX-1, with IC50 values of 0.03 μM for COX-1 and 1.2 μM for COX-2. Tenidap exhibits anti-inflammatory and anti-rheumatic effects. Tenidap is a specific inhibitor of SLC26A3.
    Tenidap sodium
  • HY-Z7640
    4-Desmethyl-2-methyl celecoxib
    		Inhibitor
    4-Desmethyl-2-methyl celecoxib (Compound 1g) is an orally active and selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 value of 0.069 μM. 4-Desmethyl-2-methyl celecoxib shows anti-inflammatory, analgesic, and antipyretic activities. 4-Desmethyl-2-methyl celecoxib can reduces the synthesis of prostaglandins. 4-Desmethyl-2-methyl celecoxib is promising for research of inflammatory diseases and pain-related diseases, such as rheumatoid arthritis and osteoarthritis.
    4-Desmethyl-2-methyl celecoxib
  • HY-W740572
    O-Desmethyl-N-deschlorobenzoyl Indomethacin
    		Inhibitor
    O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin (HY-14397). It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase. It has also been used in the synthesis of prostaglandin D2 (HY-101988) receptor antagonists.
    O-Desmethyl-N-deschlorobenzoyl Indomethacin
  • HY-B0138R
    Ketorolac (tromethamine salt) (Standard)
    		Inhibitor
    Ketorolac (tromethamine salt) (Standard) is the analytical standard of Ketorolac (tromethamine salt). This product is intended for research and analytical applications. Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
    Ketorolac (tromethamine salt) (Standard)
  • HY-106628R
    Sudoxicam (Standard)
    		Antagonist
    Sudoxicam (Standard) is the analytical standard of Sudoxicam. This product is intended for research and analytical applications. Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity.
    Sudoxicam (Standard)
  • HY-157136
    LFS-1107
    LFS-1107 is a reversible CRM1 inhibitor (Kd: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research.
    LFS-1107
  • HY-15762R
    Valdecoxib (Standard)
    		Inhibitor
    Valdecoxib (Standard) is the analytical standard of Valdecoxib. This product is intended for research and analytical applications. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.
    Valdecoxib (Standard)
  • HY-N9086A
    (rac)-Poriol
    		Ligand
    (rac)-Poriol (5,7,4'-Trihydroxy-6-methylflavanone) exhibits antioxidant activity, and scavenges free radical DPPH with an IC50 of 0.18 µg/mL. (rac)-Poriol inhibits the LPS (HY-D1056)-induced NO generation in RAW264.7 (98.35% inhibition rate at 10 μM), and exhibits anti-inflammatory activity. (rac)-Poriol exhibits good binding affinity with iNOS, COX-1, COX-2, TNF-α, and IL-1β.
    (rac)-Poriol
  • HY-N0774R
    Isofraxidin (Standard)
    		Inhibitor
    Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation.
    Isofraxidin (Standard)
  • HY-168766
    O-Acetylsalicylhydroxamic acid
    		Inhibitor
    O-Acetylsalicylhydroxamic acid is an acetylation inhibitor of prostaglandin H2 synthase that can suppress PGE2 synthesis in the body and block the cyclooxygenase activity of PGHS in vitro. O-Acetylsalicylhydroxamic acid requires the presence of the active site residue Ser-529 to act on human PGHS-1; the S529A mutant is resistant to the inactivation effects of this inhibitor.
    O-Acetylsalicylhydroxamic acid
  • HY-N6968R
    α-Humulene (Standard)
    		Inhibitor
    α-Humulene (Standard) is the analytical standard of α-Humulene. This product is intended for research and analytical applications. α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC50=15±2 μg/mL). α-Humulene inhibits COX-2 and iNOS expression.
    α-Humulene (Standard)
  • HY-120232
    ABT-963
    		Inhibitor
    ABT-963 is a selective cyclooxygenase-2 (COX-2) inhibitor for the study of pain and inflammation.
    ABT-963
  • HY-17474R
    Parecoxib (Standard)
    		Inhibitor
    Parecoxib (Standard) is the analytical standard of Parecoxib. This product is intended for research and analytical applications. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
    Parecoxib (Standard)
  • HY-B0167AR
    Sodium Salicylate (Standard)
    		Inhibitor
    Sodium Salicylate (Standard) is the analytical standard of Sodium Salicylate. This product is intended for research and analytical applications. Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle.
    Sodium Salicylate (Standard)
  • HY-N15272
    Artocarpesin
    		Inhibitor
    Artocarpesin is a flavonoid compound. Artocarpesin has inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA). Artocarpesin inhibits the production of NO, PGE2 and ROS by inhibiting COX-2 and iNOS expression, and plays an anti-inflammatory role. In addition, Artocarpesin inhibits platelet aggregation by inhibiting cyclic nucleotides and MAPKs, which can be used in the study of cardiovascular diseases.
    Artocarpesin
  • HY-B2137S
    S-(+)-Ketoprofen-d3
    		Inhibitor
    S-(+)-Ketoprofen-d3 ((S)-Ketoprofen-d3) is deuterium labeled S-(+)-Ketoprofen. S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
    S-(+)-Ketoprofen-d<sub>3</sub>
  • HY-10582R
    Flurbiprofen (Standard)
    		Inhibitor
    Flurbiprofen (Standard) is the analytical standard of Flurbiprofen. This product is intended for research and analytical applications. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer.
    Flurbiprofen (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
COX Isoform Comparison

COX

COX-1

COX-2

COX-3

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Please try each isoform separately.

COX Inhibitors, Activators & Modulators
Product NameCOXCOX-1COX-2COX-3Purity    
Acetaminophen 
COX-1, IC50: 113.7 μM
COX-2, IC50: 25.8 μM
 99.98%
Indomethacin 
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
 99.91%
EIPA  
COX-2
 99.73%
Celecoxib 
COX-1, IC50: 15 μM
COX-2, IC50: 40 nM
 99.89%
Aspirin 
COX-1, IC50: 27.75 μM
COX-2, IC50: 1.17 mM
 99.90%
Oxidopamine hydrobromide  
COX-2
 99.95%
Oxidopamine hydrochloride  
COX-2
 99.91%
Gallic acid  
COX-2
 99.99%
Diclofenac 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 99.92%
Ibuprofen 
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
 99.97%
Catechin 
COX-1, IC50: 1.4 μM
  99.57%
20(S)-Ginsenoside Rg3  
COX-2
 99.65%
(-)-Epicatechin 
COX-1, IC50: 3.2 μM
  99.00%
Meloxicam 
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
 99.59%
Naproxen 
COX-1, IC50: 9.55 μM
COX-2, IC50: 5.65 μM
 99.98%
Diclofenac Sodium 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 99.94%
Carprofen 
COX-1, IC50: 22.3 μM
COX-2, IC50: 3.9 μM
 99.83%
Salicylic acid  
COX-2
 98.42%
NS-398  
COX-2, IC50: 3.8 μM
 99.71%
Xanthohumol 
COX-1
COX-2
 99.97%
(-)-Epicatechin gallate 
COX-1, IC50: 7.5 μM
  99.61%
Ketoprofen 
COX-1, IC50: 2 nM (in human blood monocytes)
COX-2, IC50: 26 nM (in human blood monocytes)
 99.95%
Rebamipide  
COX-2
 99.94%
(S)-(+)-Ibuprofen 
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
 99.98%
Phenacetin   
COX-3, IC50: 102 μM
99.95%
Aspirin (Standard) 
COX-1
COX-2
 99.85%
EIPA hydrochloride  
COX-2
 98.31%
SC-560 
COX-1, IC50: 9 nM
COX-2, IC50: 6.3 μM
 99.79%
Iguratimod  
COX-2, IC50: 20 μM
 98.49%
Sodium Salicylate  
COX-2
 99.93%
Neochlorogenic acid  
COX-2
 99.77%
Valdecoxib 
COX-1, IC50: 140 μM
COX-2, IC50: 5 nM
 99.90%
Parecoxib  
COX-2
 99.29%
Isoorientin  
COX-2, IC50: 39 μM
 98.32%
Piroxicam 
COX-1, IC50: 47 μM (in human monocytes)
COX-2, IC50: 25 μM (in human monocytes)
 99.71%
Ginsenoside C-K  
COX-2
 99.92%
Guaiacol  
COX-2
 99.95%
Rutaecarpine 
COX-1, IC50: 8.7 μM (in BMMC)
COX-2, IC50: 0.28 μM (in BMMC)
 99.09%
Mefenamic acid 
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 μM
 99.95%
Harpagoside 
COX-1
COX-2
 99.88%
Psoralidin  
COX-2
 99.90%
Flurbiprofen
COX
COX-1
COX-2
 99.98%
Ibuprofen sodium 
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
 99.98%
Niflumic acid  
COX-2, IC50: 100 nM
 99.88%
Nimesulide  
COX-2, IC50: 0.07-70 μM
 99.90%
Ginsenoside Rd  
COX-2
 99.88%
Fenofibric acid  
COX-2, IC50: 48 μM
 99.94%
Prim-O-glucosylcimifugin  
COX-2
 99.94%
Etoricoxib 
COX-1, IC50: 116 μM (in human whole blood)
COX-2, IC50: 1.1 μM (in human whole blood)
 99.86%
Salicin
COX
   99.77%
Diflunisal
COX
   99.93%
Rofecoxib  
Human COX-2, IC50: 18 nM (in Chinese hamster ovary cells)
Human COX-2, IC50: 26 nM (in human osteosarcoma cells)
 99.89%
Paradol  
COX-2
 99.87%
Ginsenoside Rg5  
COX-2
 99.87%
Broussonin E  
COX-2
 98.18%
cis-5-Dodecenoic acid 
COX-1
COX-2
 99.76%
Gamma-Mangostin  
COX-2
 99.91%
γ-Tocopherol
Cyclooxygenase
   99.63%
Roburic acid 
COX-1, IC50: 5 μM
COX-2, IC50: 9 μM
 99.83%
Ethyl Caffeate  
COX-2
 98.06%
Isofraxidin  
COX-2
 99.00%
Cafestol  
COX-2
 99.91%
Madecassic acid  
COX-2
 99.81%
Sinapaldehyde  
COX-2, IC50: 47.8 μM
 99.96%
Lumiracoxib 
COX-1, Ki: 3 μM
COX-2, Ki: 0.06 μM
 99.65%
Licofelone
COX, IC50: 0.21 μM
   99.84%
Dihydrokavain 
COX-1
COX-2
 99.94%
Pectolinarigenin  
COX-2
 99.79%
S-(+)-Ketoprofen 
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
 99.88%
Imrecoxib 
Human COX-1, IC50: 115 nM
Human COX-2, IC50: 18 nM
 99.48%
α-Humulene  
COX-2
 98.55%
Syringaldehyde  
COX-2, IC50: 19.2 μM
 99.96%
[10]-Shogaol  
COX-2, IC50: 7.5 μM
 99.88%
Indobufen
COX
   99.98%
Avicularin  
COX-2
 99.80%
Lornoxicam 
COX-1, IC50: 5 nM (in cells)
COX-2, IC50: 45 nM (in cells)
 99.36%
Oxaprozin 
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
 99.95%
[8]-Shogaol  
COX-2, IC50: 17.5 μM
 99.93%
Ketorolac 
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 99.93%
Tolfenamic Acid  
COX-2, IC50: 13.49 μM (in cell)
 99.94%
NF-κB/MAPK-IN-1  
COX-2
 98.42%
Naproxen sodium 
COX-1, IC50: 9.55 μM (in intact cells )
COX-2, IC50: 5.65 μM (in intact cells )
 99.87%
Glafenine 
COX-1
COX-2
 98.75%
Dendrophenol  
COX-2
 99.93%
Fenoprofen Calcium hydrate
COX
   99.69%
Glafenine hydrochloride 
COX-1
COX-2
 99.25%
SC-236 
COX-1, IC50: 17.8 μM
COX-2, IC50: 10 nM
 99.56%
Jaceosidin  
COX-2
 99.51%
Ampiroxicam
COX
   98.43%
Etodolac 
COX-1, IC50: ∼50000 nM (in CHO cells)
COX-2, IC50: 41 nM (in CHO cells)
 99.77%
3,3'-Diiodo-L-thyronine
COX
   
Bromfenac sodium 
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
 99.92%
Pranoprofen 
COX-1
COX-2
 98.65%
Nabumetone  
COX-2
 99.90%
Deracoxib  
COX-2
 99.65%
FK 3311  
COX-2
 98.04%
Oxatomide  
COX-2
 99.56%
S-(+)-Marmesin  
COX-2
 99.73%
Parecoxib Sodium  
COX-2
 99.94%
(-)-Catechin gallate 
COX-1
COX-2
 99.98%
Ketorolac tromethamine salt 
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 99.91%
(S)-Flurbiprofen 
COX-1, IC50: 0.48 μM
COX-2, IC50: 0.47 μM
 99.89%
Ginsenoside Rb3  
COX-2
 99.12%
Gnetol 
COX-1, IC50: 0.78 μM
  99.86%
Humulone  
COX-2
 99.46%
Macelignan  
COX-2
 99.95%
α-Spinasterol 
COX-1, IC50: 16.17 μM
COX-2, IC50: 7.76 μM
 99.15%
Salicylic acid-d6  
COX-2
 99.32%
Zaltoprofen 
COX-1, IC50: 1.3 μM
COX-2, IC50: 0.34 μM
 99.28%
Ufenamate  
COX-2
 99.89%
N-tert-Butyl-α-phenylnitrone  
COX-2
 99.94%
Hexahydrocurcumin  
COX-2
 99.88%
β-Elemonic acid  
COX-2
 99.90%
AG-024322 
COX-1, Ki: 2.3 nM
COX-2, Ki: 3 nM
 98.53%
Terameprocol  
COX-2
 99.33%
(E)-Ethyl p-methoxycinnamate 
COX-1, IC50: 1.12 μM
COX-2, IC50: 0.83 μM
 99.53%
DuP-697 
hCOX-1, IC50: 800 nM
hCOX-2, IC50: 10 nM
 99.67%
Fenbufen 
COX-1, IC50: 3.9 μM
COX-2, IC50: 8.1 μM
 99.33%
Tenidap 
COX-1, IC50: 0.03 μM
COX-2, IC50: 1.2 μM
 99.32%
Triflusal  
COX-2, IC50: 280 μM
COX-2, IC50: 160 μM (in human blood)
 99.83%
Tolmetin 
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 99.82%
Acemetacin 
COX-1, IC50: 85 μM (in human intact cell)
  99.97%
Tenoxicam 
COX-1
COX-2
 99.93%
Loxoprofen 
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
 99.80%
Moracin C  
COX-2
 99.54%
Felbinac 
COX-1, IC50: 865.68 nM
COX-2, IC50: 976 nM
 99.74%
Saponarin  
COX-2
 98.84%
TFAP 
COX-1, IC50: 0.8 μM
  99.98%
Loxoprofen sodium 
COX-1, IC50: 6.5 μM
COX-2, IC50: 13.5 μM
 99.98%
Inulicin  
COX-2
 99.94%
Nepafenac 
COX-1, IC50: 64.3 μM
  99.51%
Aceclofenac 
COX-1, IC50: 7.3 μM
COX-2, IC50: 3 μM
 99.91%
PTUPB 
COX-1, IC50: 100 μM
COX-2, IC50: 1.26 μM
 98.69%
Diclofenac potassium 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 nM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 nM
 99.99%
Adelmidrol  
COX-2
 ≥98.0%
CAY10404 
COX-1, IC50: >500 μM
COX-2, IC50: 1 nM
 99.69%
Eicosatetraynoic acid
COX, ID50: 8 μM
   ≥99.0%
Gallic acid hydrate  
COX-2
 99.81%
Asaraldehyde  
COX-2
 99.83%
Diclofenac diethylamine 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 99.95%
Tilmicosin phosphate  
COX-2
 ≥98.0%
Flunixin meglumine 
COX-1, IC50: 0.55 μM
COX-2, IC50: 3.24 μM
 99.65%
Ketorolac-d5 
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 98.31%
Phenacetin (Standard)   
COX-3
99.97%
Mofezolac 
COX-1, IC50: 1.44 nM
COX-2, IC50: 447 nM
 99.34%
Salicylic acid (Standard)  
COX-2
 
SC-58125 
hCOX-1, IC50: >100 μM
hCOX-2, IC50: 0.04 μM
 99.92%
Byakangelicol  
COX-2
 99.87%
Phenidone
COX
   99.00%
Ampyrone
COX
   99.72%
Firocoxib 
COX-1, IC50: 7.5 μM
COX-2, IC50: 0.13 μM
 99.54%
7,3',4'-Tri-O-methylluteolin  
COX-2
 99.28%
2,5-Di-tert-butylhydroquinone  
COX-2, IC50: 14.1 μM
 99.90%
Amfenac Sodium Hydrate  
COX-2
 99.07%
Alminoprofen  
COX-2
 99.91%
FR122047 
COX-1, IC50: 28 nM
  99.55%
Phenethyl ferulate
COX, IC50: 4.35 μM
   99.88%
Bromfenac sodium hydrate 
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
 99.94%
(+)-Catechin hydrate 
COX-1, IC50: 1.4 μM
  99.59%
Columbin 
COX-1, EC50: 327 μM
COX-2, EC50: 53.1 μM
 99.86%
Acetaminophen (Standard) 
COX-1
COX-2
 99.94%
Timosaponin A1  
COX-2, IC50: 36.43 μM
 99.70%
Propyphenazone
COX
   99.85%
Hydrangenol  
COX-2
 99.63%
β-Amyrone  
COX-2
 99.87%
Peonidin chloride  
COX-2
 98.70%
Valeryl salicylate 
COX-1
  ≥99.0%
α-​Chaconine  
COX-2
 99.76%
Sphondin  
COX-2
 99.70%
Lupeol acetate  
COX-2
 ≥98.0%
Phenyl β-D-glucopyranoside  
COX-2
 99.85%
Flurbiprofen axetil
COX
   99.85%
Fenofibric acid (Standard)  
COX-2
 99.16%
Enflicoxib  
COX-2
 99.90%
Oleanolic acid 28-O-β-D-glucopyranoside  
COX-2
 99.42%
Polmacoxib  
COX-2, IC50: 0.1 μg/mL
 99.70%
(-)-Epicatechin gallate (Standard) 
COX-1
  
Mavacoxib  
COX-2
 99.04%
Otenaproxesul 
COX-1
COX-2
 98.03%
Indazole-Cl  
COX-2
 98.72%
Isoxicam 
COX-1
COX-2
 99.83%
Pelubiprofen  
COX-2
 99.27%
Iminostilbene  
COX-2
 99.34%
BW 755C 
COX-1, IC50: 0.65 μg/mL
COX-2, IC50: 1.2 μg/mL
 
Tolmetin sodium dihydrate 
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 99.94%
Nitroflurbiprofen
COX
   99.64%
Vedaprofen 
COX-1
  99.81%
Tebufelone  
COX-2
 99.52%
Teriflunomide impurity 3 
COX-1, IC50: 30 μM
  99.75%
Nitroaspirin 
COX-1
  98.57%
Indomethacin-d4 
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
 99.78%
ARN14494  
COX-2
 99.08%
Desmethyl Celecoxib  
COX-2, IC50: 32 nM
 99.42%
Pamicogrel
Cyclooxygenase
   99.44%
Floctafenine 
COX-1
COX-2
 
GW-406381  
COX-2
 99.69%
(-)-Epicatechin (Standard) 
COX-1
  
Anemarsaponin B  
COX-2
 
Hamaudol 
COX-1, IC50: 0.3 mM
COX-2, IC50: 0.57 mM
 99.59%
Shizukaol B  
COX-2
 
Cimicoxib  
COX-2
 98.02%
Madecassic acid (Standard)  
COX-2
 
3,9-Dihydroeucomin  
COX-2
 
SC57666  
COX-2, IC50: 26 nM
 98.94%
FR-188582  
COX-2, IC50: 17 nM
 99.12%
Plantanone B 
Ovine COX-1, IC50: 21.78±0.2 μM
Ovine COX-2, IC50: 44.01±0.42 μM
 99.16%
RWJ 63556  
COX-2
 99.35%
Ketoprofen (lysinate) 
COX-1, IC50: 2 nM
COX-2, IC50: 26 nM
 
COX-2-IN-6  
COX-2
 98.80%
Aspirin lithium 
COX-1
COX-2
 
Ocarocoxib  
COX-2, IC50: 1.4 μM
 99.94%
Indomethacin sodium 
COX-1, IC50: 18 nM
COX-2, IC50: 26 nM
 
COX-2-IN-28 
COX-1, IC50: 13.21 μM
COX-2, IC50: 0.054 μM
 
Tolmetin sodium 
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 
Jaceosidin (Standard)  
COX-2
 
Daturaolone 
COX-1
  
Antitumor agent-77  
COX-2
 
COX-1-IN-1 
COX-1, IC50: 0.23 μM
COX-2, IC50: 50 μM
 
COX-2/LOX-IN-1  
COX-2, IC50: 0.55 μM
 
COX-1/2-IN-2 
COX-1, IC50: 9.7±0.09 μM
COX-2, IC50: 4.6±1.45 μM
 
Topo I/COX-2-IN-2  
COX-2, IC50: 2.31 μM
 
TX-1123 
COX-1, IC50: 15.7 μM
COX-2, IC50: 1.16 nM
 
COX-2-IN-21 
COX-1, IC50: 12.4 μM
COX-2, IC50: 0.039 μM
 
Longiferone B  
COX-2
 
COX-2-IN-27 
COX-1, IC50: 13.22 μM
COX-2, IC50: 0.045 μM
 
LM-4108 
Ovine COX-1, IC50: >66 μM
Human COX-2, IC50: 60 nM
 
STAT1/3-IN-1  
COX-2
 
COX-2-IN-5  
COX-2, IC50: 0.65 μM
 
Ginsenoside Rb3 (Standard)  
COX-2
 
COX-2-IN-17 
COX-1, IC50: >10 μM
COX-2, IC50: 0.02 μM
 
VI-60  
COX-2
 
Ginsenoside C-K (Standard)  
COX-2
 
COX-2/15-LOX-IN-6  
COX-2, IC50: 0.201 μM
 
Antitumor agent-78  
COX-2
 
COX-2-IN-51  
COX-2, IC50: 70.7 nM
 
LY256548
Cyclooxygenase
   
2,5-Dimethoxy-3-glucopyranosylcinnamic alcohol 
COX-1
  
Ginsenoside Rd (Standard)  
COX-2
 
Heterophdoid A  
COX-2
 
COX-2-IN-47  
COX-2, IC50: 0.03 μM
 
iNOS/COX-2-IN-1  
COX-2
 
COX-1/2-IN-1 
COX-1, IC50: 9.7±0.09 μM
COX-2, IC50: 4.6±1.45 μM
 
COX-2-IN-46  
COX-2, IC50: 87.74 nM
 
COX-2-IN-31 
COX-1, IC50: 12.5 μM
COX-2, IC50: 60 nM
 
COX-2-IN-10  
COX-2
 
Clematomandshurica saponin B  
COX-2
 
Kadsulignan N  
COX-2
 
COX-2/sEH-IN-1 
COX-1, IC50: 8.72 μM
COX-2, IC50: 1.24 μM
 
Meloxicam sodium 
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
 
COX-2-IN-48  
Human COX-2, IC50: 51.7 nM
 
COX-2-IN-30 
COX-1, IC50: 10.4 μM
COX-2, IC50: 49 nM
 
(S)-(+)-Ibuprofen-d3 
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
 98.87%
cis-5-Dodecenoic acid (Standard) 
COX-1
COX-2
 
Oxaprozin potassium 
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
 
Taraxerol acetate 
COX-1, IC50: 116.3 μM
COX-2, IC50: 94.7 μM
 
COX-2-IN-16  
COX-2, IC50: 102 μM
 
EGFR/COX-2-IN-1 
COX-1, IC50: 20.1 μM
COX-2, IC50: 1.52 μM
 
COX-2-IN-14  
COX-2
 
Ermanin  
COX-2
 
COX-1/2-IN-3 
COX-1
COX-2
 
COX-2/PI3K-IN-2  
COX-2, Ki: 3.02 nM
 
Lucidone  
COX-2
 
COX-2-IN-35  
COX-2, IC50: 4.37 nM
 
COX-1/2-IN-8 
COX-1, IC50: 2.14 ± 0.0 μM
COX-2, IC50: 0.58 ± 0.0 μM
 
Pifoxime 
COX-1
COX-2
 
COX-2-IN-32  
COX-2
 
WYZ90 
COX-1, IC50: 5734 nM
COX-2, IC50: 75 nM
 
Bromfenac 
Human COX-1, IC50: 5.56 nM
Human COX-2, IC50: 7.45 nM
 
Loxoprofen sodium (dihydrate) 
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
 
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone 
COX-1
COX-2
 99.64%
COX-1-IN-2 
COX-1, IC50: 38.76 nM
  
COX-2-IN-19 
COX-1, IC50: 117.8 μM
COX-2, IC50: 1.76 μM
 
COX-2-IN-52 
COX-1, IC50: 15.98 μM
COX-2, IC50: 54 nM
 
COX-2/15-LOX-IN-1 
COX-1, IC50: 10.65 μM
COX-2, IC50: 0.075 μM
 
COX-2-IN-34  
COX-2, IC50: 0.42 μM
 98.87%
Anti-inflammatory agent 78 
COX-1
COX-2
 
COX-2-IN-40  
COX-2, IC50: 14.86 μM
 
COX-2-IN-29 
COX-1, IC50: > 10 μM
COX-2, IC50: 0.005 μM
 
Mefenamic acid-d4 
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 nM
 ≥98.0%
COX-2-IN-42  
COX-2
 
(±)-Aiphanol 
COX-1, IC50: 1.9 μM
COX-2, IC50: 9.9 μM
 
Balanophonin  
COX-2
 
BMP-4  
COX-2
 
COX-2-IN-23 
COX-1, IC50: 20.14 μM
COX-2, IC50: 0.28 μM
 
Anti-inflammatory agent 20  
COX-2
 
COX-2-IN-20 
COX-1, IC50: 19.3 μM
COX-2, IC50: 17.9 nM
 
Flunixin 
COX-1, IC50: 0.55 μM
COX-2, IC50: 3.24 μM
 
COX-2-IN-22  
COX-2, IC50: 8.6 μM
 
COX-2/NLRP3-IN-1  
COX-2, IC50: 1.53 μM
 
COX-2-IN-43 
COX-1, IC50: 0.983 μM
COX-2, IC50: 0.247 μM
 
MCI  
COX-2, IC50: 1.23 μM
 
Axinelline A 
COX-1, IC50: 8.89 μM
COX-2, IC50: 2.22 μM
 
L 748780 
COX-1, IC50: > 100 μM
COX-2, IC50: 0.5 μM
 
COX-2-IN-26 
COX-1, IC50: 10.61 μM
COX-2, IC50: 0.067 μM
 
20(S)-Ginsenoside Rg3 (Standard)  
COX-2
 
Anti-inflammatory agent 56  
COX-2
 
LY 178002
Cyclooxygenase
   
15-LOX-IN-2 
COX-1, IC50: 7.510 μM
COX-2, IC50: 0.190 μM
 
COX-2/PI3K-IN-1  
COX-2, Ki: 3.24 nM
 
Timegadine
COX, IC50: 5 nM (in rabbit platelets)
COX, IC50: 20 μM (in rat brain)
   
Eltenac 
COX-1, IC50: 0.03 μM
COX-2, IC50: 0.03 μM
 
Cudraflavone B 
COX-1
COX-2
 
AChE-IN-82 
COX-1, IC50: 60.41 μM
COX-2, IC50: 0.187 μM
 
Akt/NF-κB/MAPK-IN-1  
COX-2
 
Nimesulide-d5  
COX-2, IC50: 0.07-70 μM
 
COX-2-IN-49  
COX-2, IC50: 2.671 μM
 
PYZ18  
COX-2, IC50: 7.07 μM
 
Avicularin (Standard)  
COX-2
 
COX-2-IN-44 
COX-1, IC50: 1.14 μM
COX-2, IC50: 0.18 μM
 
COX-2-IN-24  
COX-2, IC50: 0.17 μM
 
COX-2/5-LOX-IN-3 
COX-1, IC50: 45.73 μM
COX-2, IC50: 5.45 μM
 
Akt/NF-κB/JNK-IN-1  
COX-2
 
TLR4-IN-2  
COX-2
 
RS-57067  
COX-2, Ki: 16.9 μM
 
NCX 466 
COX-1
COX-2
 
Indomethacin N-octyl amide 
COX-1, IC50: 66 μM
COX-2, IC50: 0.04 μM
 
BF389 
COX-1, IC50: 4 μg/mL
COX-2, IC50: 8 μg/mL
 
Fenoprofen Calcium
COX
   
COX-1/2-IN-9 
COX-1, IC50: 0.031 μM
COX-2, IC50: 0.010 μM
 
Multinoside A  
COX-2
 
Tenidap sodium 
COX-1
COX-2
 
4-Desmethyl-2-methyl celecoxib  
COX-2, IC50: 0.069 μM
 
LFS-1107  
COX-2
 
ZLJ-6 
COX-1, IC50: 0.73 μM
COX-2, IC50: 0.31 μM
 
Flosulide  
COX-2
 
Thioflosulide  
COX-2, IC50: 2.3 nM
 
S-2474 
COX-1, IC50: 27 μM
COX-2, IC50: 11 nM
 
Saponarin (Standard)  
COX-2
 
Catechin hydrate 
COX-1, IC50: 1.4 μM
  
N1-Acetyl-5-methoxykynuramine hydrochloride  
COX-2
 
COX-2-IN-1  
COX-2, IC50: 3.9 μM
 
COX-2-IN-2  
COX-2, IC50: 240 nM
 99.53%
Tilmacoxib  
Human COX-2, IC50: 85 nM
 ≥99.0%
COX/5-LO-IN-1
COX
   
SC58451  
COX-2