2. Signaling Pathways
  3. Immunology/Inflammation
  4. COX

COX

COX

Cyclooxygenase

COX

Related Products

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Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX Isoform Specific Products:

COX Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B2137S
    S-(+)-Ketoprofen-d3
    		Inhibitor
    S-(+)-Ketoprofen-d3 ((S)-Ketoprofen-d3) is deuterium labeled S-(+)-Ketoprofen. S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
    S-(+)-Ketoprofen-d<sub>3</sub>
  • HY-10582R
    Flurbiprofen (Standard)
    		Inhibitor
    Flurbiprofen (Standard) is the analytical standard of Flurbiprofen. This product is intended for research and analytical applications. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer.
    Flurbiprofen (Standard)
  • HY-17009R
    Iguratimod (Standard)
    		Inhibitor
    Iguratimod (Standard) is the analytical standard of Iguratimod. This product is intended for research and analytical applications. Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
    Iguratimod (Standard)
  • HY-113807
    ZLJ-6
    		Inhibitor
    ZLJ-6 is a dual COX and 5-LOX inhibitor with oral activity. The IC50 values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity.
    ZLJ-6
  • HY-101751
    Chlorthenoxazine
    		98.43%
    Chlorthenoxazine is a nonsteroidal anti-inflammatory agent.
    Chlorthenoxazine
  • HY-U00083
    Flosulide
    		Inhibitor
    Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.
    Flosulide
  • HY-19217
    Thioflosulide
    		Inhibitor
    Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC50 of 2.3 nM, and shows anti-inflammatory activity.
    Thioflosulide
  • HY-19212
    S-2474
    		Inhibitor
    S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.
    S-2474
  • HY-157583
    COX-2-IN-39
    		Inhibitor
    COX-2-IN-39 (compound 44) is a potent inhibitor of COX-2, with the IC50 value of 0.4 nM.
    COX-2-IN-39
  • HY-78131AR
    (S)-(+)-Ibuprofen (Standard)
    		Inhibitor
    (S)-(+)-Ibuprofen (Standard) is the analytical standard of (S)-(+)-Ibuprofen. This product is intended for research and analytical applications. (S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects.
    (S)-(+)-Ibuprofen (Standard)
  • HY-W654009
    Loxoprofen-d3
    		Inhibitor
    Loxoprofen-d3 is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity.
    Loxoprofen-d<sub>3</sub>
  • HY-B0440R
    Tenoxicam (Standard)
    		Inhibitor
    Tenoxicam (Standard) is the analytical standard of Tenoxicam. This product is intended for research and analytical applications. Tenoxicam (Ro-12-0068), an antiinflammatory agent with analgesic and antipyretic properties.
    Tenoxicam (Standard)
  • HY-B0578R
    Loxoprofen (Standard)
    		Inhibitor
    Loxoprofen (Standard) is the analytical standard of Loxoprofen. This product is intended for research and analytical applications. Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity.
    Loxoprofen (Standard)
  • HY-107336
    Cyclovalone
    		Inhibitor
    Cyclovalone (Beveno) is a synthetic curcumin derivate, which inihibits cyclooxygenase and exhibits anti-inflammatory, antitumor and antioxidant activities. Cyclovalone inhibits cell proliferation in normal and malignant prostatic cells. Cyclovalone ist orally active.
    Cyclovalone
  • HY-N1181R
    Tamarixetin (Standard)
    		Inhibitor
    Tamarixetin (Standard) is the analytical standard of Tamarixetin. This product is intended for research and analytical applications. Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways.
    Tamarixetin (Standard)
  • HY-B0363S1
    Nimesulide-13C6
    		Inhibitor
    Nimesulide-13C6 (R805-13C6) is 13C labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.
    Nimesulide-<sup>13</sup>C<sub>6</sub>
  • HY-100516R
    Cimicoxib (Standard)
    		Inhibitor
    Cimicoxib (Standard) is the analytical standard of Cimicoxib. This product is intended for research and analytical applications. Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar[1].
    Cimicoxib (Standard)
  • HY-119469
    Aceclofenac ethyl ester
    		Control
    Aceclofenac ethyl ester is an impurity of Aceclofenac (HY-B0634).
    Aceclofenac ethyl ester
  • HY-108297R
    Piketoprofen (Standard)
    		Inhibitor
    Piketoprofen (Standard) is the analytical standard of Piketoprofen. This product is intended for research and analytical applications. Piketoprofen is a non-steroidal anti-inflammatory reagent that can be used as a cream preparation for the study of soft tissue rheumatism.
    Piketoprofen (Standard)
  • HY-101840AR
    EIPA hydrochloride (Standard)
    		Inhibitor
    EIPA (hydrochloride) (Standard) is the analytical standard of EIPA (hydrochloride). This product is intended for research and analytical applications. EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][5].
    EIPA hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
COX Isoform Comparison

COX

COX-1

COX-2

COX-3

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Please try each isoform separately.

COX Inhibitors, Activators & Modulators
Product NameCOXCOX-1COX-2COX-3Purity    
Acetaminophen 
COX-1, IC50: 113.7 μM
COX-2, IC50: 25.8 μM
 99.98%
Indomethacin 
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
 99.91%
EIPA  
COX-2
 99.73%
Celecoxib 
COX-1, IC50: 15 μM
COX-2, IC50: 40 nM
 99.89%
Aspirin 
COX-1, IC50: 27.75 μM
COX-2, IC50: 1.17 mM
 99.90%
Oxidopamine hydrobromide  
COX-2
 99.95%
Oxidopamine hydrochloride  
COX-2
 99.91%
Gallic acid  
COX-2
 99.99%
Diclofenac 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 99.92%
Ibuprofen 
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
 99.97%
Catechin 
COX-1, IC50: 1.4 μM
  99.57%
20(S)-Ginsenoside Rg3  
COX-2
 99.94%
(-)-Epicatechin 
COX-1, IC50: 3.2 μM
  99.00%
Naproxen 
COX-1, IC50: 9.55 μM
COX-2, IC50: 5.65 μM
 99.98%
Meloxicam 
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
 99.59%
Diclofenac Sodium 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 99.94%
Carprofen 
COX-1, IC50: 22.3 μM
COX-2, IC50: 3.9 μM
 99.83%
NS-398  
COX-2, IC50: 3.8 μM
 99.71%
Salicylic acid  
COX-2
 98.42%
Xanthohumol 
COX-1
COX-2
 99.97%
Rebamipide  
COX-2
 99.98%
(-)-Epicatechin gallate 
COX-1, IC50: 7.5 μM
  98.57%
Phenacetin   
COX-3, IC50: 102 μM
99.95%
Ketoprofen 
COX-1, IC50: 2 nM (in human blood monocytes)
COX-2, IC50: 26 nM (in human blood monocytes)
 99.95%
Aspirin (Standard) 
COX-1
COX-2
 99.85%
(S)-(+)-Ibuprofen 
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
 99.98%
EIPA hydrochloride  
COX-2
 98.31%
SC-560 
COX-1, IC50: 9 nM
COX-2, IC50: 6.3 μM
 99.79%
Iguratimod  
COX-2, IC50: 20 μM
 98.49%
Sodium Salicylate  
COX-2
 99.93%
Neochlorogenic acid  
COX-2
 99.77%
Ginsenoside C-K  
COX-2
 99.92%
Valdecoxib 
COX-1, IC50: 140 μM
COX-2, IC50: 5 nM
 99.90%
Isoorientin  
COX-2, IC50: 39 μM
 99.26%
Parecoxib  
COX-2
 99.29%
Piroxicam 
COX-1, IC50: 47 μM (in human monocytes)
COX-2, IC50: 25 μM (in human monocytes)
 99.71%
Guaiacol  
COX-2
 99.95%
Harpagoside 
COX-1
COX-2
 99.88%
Rutaecarpine 
COX-1, IC50: 8.7 μM (in BMMC)
COX-2, IC50: 0.28 μM (in BMMC)
 99.09%
Mefenamic acid 
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 μM
 99.95%
Nimesulide  
COX-2, IC50: 0.07-70 μM
 99.90%
Niflumic acid  
COX-2, IC50: 100 nM
 99.88%
Ginsenoside Rd  
COX-2
 99.88%
Psoralidin  
COX-2
 99.90%
Ibuprofen sodium 
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
 99.98%
Flurbiprofen
COX
COX-1
COX-2
 99.98%
Prim-O-glucosylcimifugin  
COX-2
 99.94%
Fenofibric acid  
COX-2, IC50: 48 μM
 99.94%
Rofecoxib  
Human COX-2, IC50: 18 nM (in Chinese hamster ovary cells)
Human COX-2, IC50: 26 nM (in human osteosarcoma cells)
 99.84%
Salicin
COX
   99.77%
Diflunisal
COX
   99.93%
Etoricoxib 
COX-1, IC50: 116 μM (in human whole blood)
COX-2, IC50: 1.1 μM (in human whole blood)
 99.90%
Ginsenoside Rg5  
COX-2
 99.87%
Gamma-Mangostin  
COX-2
 99.91%
Paradol  
COX-2
 99.42%
Broussonin E  
COX-2
 98.18%
Ethyl Caffeate  
COX-2
 98.06%
cis-5-Dodecenoic acid 
COX-1
COX-2
 99.76%
Roburic acid 
COX-1, IC50: 5 μM
COX-2, IC50: 9 μM
 99.83%
Isofraxidin  
COX-2
 99.00%
Lumiracoxib 
COX-1, Ki: 3 μM
COX-2, Ki: 0.06 μM
 99.65%
Licofelone
COX, IC50: 0.21 μM
   99.84%
Cafestol  
COX-2
 99.91%
γ-Tocopherol
Cyclooxygenase
   99.63%
Dihydrokavain 
COX-1
COX-2
 99.94%
Madecassic acid  
COX-2
 99.81%
Imrecoxib 
Human COX-1, IC50: 115 nM
Human COX-2, IC50: 18 nM
 99.48%
α-Humulene  
COX-2
 98.55%
S-(+)-Ketoprofen 
COX-1, IC50: 13 μM
COX-2, IC50: 370 μM
 99.88%
Pectolinarigenin  
COX-2
 99.79%
Indobufen
COX
   99.98%
Tolfenamic Acid  
COX-2, IC50: 13.49 μM (in cell)
 99.94%
Avicularin  
COX-2
 99.80%
Syringaldehyde  
COX-2, IC50: 19.2 μM
 99.96%
[10]-Shogaol  
COX-2, IC50: 7.5 μM
 99.88%
Dendrophenol  
COX-2
 99.93%
[8]-Shogaol  
COX-2, IC50: 17.5 μM
 99.93%
Ketorolac 
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 99.93%
NF-κB/MAPK-IN-1  
COX-2
 98.42%
SC-236 
COX-1, IC50: 17.8 μM
COX-2, IC50: 10 nM
 99.56%
Lornoxicam 
COX-1, IC50: 5 nM (in cells)
COX-2, IC50: 45 nM (in cells)
 99.36%
Oxaprozin 
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
 99.95%
Nabumetone  
COX-2
 99.90%
Naproxen sodium 
COX-1, IC50: 9.55 μM (in intact cells )
COX-2, IC50: 5.65 μM (in intact cells )
 99.87%
Ampiroxicam
COX
   98.43%
Etodolac 
COX-1, IC50: ∼50000 nM (in CHO cells)
COX-2, IC50: 41 nM (in CHO cells)
 99.77%
Bromfenac sodium 
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
 98.52%
Jaceosidin  
COX-2
 99.51%
Pranoprofen 
COX-1
COX-2
 98.65%
Fenoprofen Calcium hydrate
COX
   99.69%
3,3'-Diiodo-L-thyronine
COX
   
Deracoxib  
COX-2
 99.65%
FK 3311  
COX-2
 98.04%
(-)-Catechin gallate 
COX-1
COX-2
 99.98%
Ketorolac tromethamine salt 
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 99.91%
(S)-Flurbiprofen 
COX-1, IC50: 0.48 μM
COX-2, IC50: 0.47 μM
 99.89%
S-(+)-Marmesin  
COX-2
 99.73%
Ufenamate  
COX-2
 99.89%
Gnetol 
COX-1, IC50: 0.78 μM
  99.86%
Parecoxib Sodium  
COX-2
 99.94%
Macelignan  
COX-2
 99.95%
Ginsenoside Rb3  
COX-2
 99.12%
α-Spinasterol 
COX-1, IC50: 16.17 μM
COX-2, IC50: 7.76 μM
 99.15%
Salicylic acid-d6  
COX-2
 99.32%
N-tert-Butyl-α-phenylnitrone  
COX-2
 99.94%
Hexahydrocurcumin  
COX-2
 99.88%
β-Elemonic acid  
COX-2
 99.90%
AG-024322 
COX-1, Ki: 2.3 nM
COX-2, Ki: 3 nM
 98.53%
Terameprocol  
COX-2
 99.33%
(E)-Ethyl p-methoxycinnamate 
COX-1, IC50: 1.12 μM
COX-2, IC50: 0.83 μM
 99.53%
Tolmetin 
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 99.82%
Zaltoprofen 
COX-1, IC50: 1.3 μM
COX-2, IC50: 0.34 μM
 99.28%
Inulicin  
COX-2
 99.94%
DuP-697 
hCOX-1, IC50: 800 nM
hCOX-2, IC50: 10 nM
 99.67%
Fenbufen 
COX-1, IC50: 3.9 μM
COX-2, IC50: 8.1 μM
 99.33%
Humulone  
COX-2
 99.46%
Tenidap 
COX-1, IC50: 0.03 μM
COX-2, IC50: 1.2 μM
 99.32%
Acemetacin 
COX-1, IC50: 85 μM (in human intact cell)
  99.97%
Tenoxicam 
COX-1
COX-2
 99.93%
Loxoprofen 
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
 99.80%
Nepafenac 
COX-1, IC50: 64.3 μM
  99.51%
Moracin C  
COX-2
 99.54%
Triflusal  
COX-2, IC50: 280 μM
COX-2, IC50: 160 μM (in human blood)
 99.83%
Felbinac 
COX-1, IC50: 865.68 nM
COX-2, IC50: 976 nM
 99.74%
Asaraldehyde  
COX-2
 99.83%
PTUPB 
COX-1, IC50: 100 μM
COX-2, IC50: 1.26 μM
 98.69%
Loxoprofen sodium 
COX-1, IC50: 6.5 μM
COX-2, IC50: 13.5 μM
 99.98%
TFAP 
COX-1, IC50: 0.8 μM
  99.98%
Ampyrone
COX
   99.72%
Aceclofenac 
COX-1, IC50: 7.3 μM
COX-2, IC50: 3 μM
 99.91%
Diclofenac potassium 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 nM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 nM
 99.99%
Adelmidrol  
COX-2
 ≥98.0%
CAY10404 
COX-1, IC50: >500 μM
COX-2, IC50: 1 nM
 99.69%
Eicosatetraynoic acid
COX, ID50: 8 μM
   ≥99.0%
Gallic acid hydrate  
COX-2
 99.81%
Tilmicosin phosphate  
COX-2
 ≥98.0%
7,3',4'-Tri-O-methylluteolin  
COX-2
 99.28%
Ketorolac-d5 
COX-1, IC50: 20 nM
COX-2, IC50: 120 nM
 98.31%
Phenacetin (Standard)   
COX-3
99.97%
Mofezolac 
COX-1, IC50: 1.44 nM
COX-2, IC50: 447 nM
 99.34%
Salicylic acid (Standard)  
COX-2
 
SC-58125 
hCOX-1, IC50: >100 μM
hCOX-2, IC50: 0.04 μM
 99.92%
Byakangelicol  
COX-2
 99.87%
Phenidone
COX
   99.00%
Firocoxib 
COX-1, IC50: 7.5 μM
COX-2, IC50: 0.13 μM
 99.54%
Diclofenac diethylamine 
Human COX-1, IC50: 4 nM (in CHO cells)
Ovine COX-1, IC50: 5.1 μM
Human COX-2, IC50: 1.3 nM (in CHO cells)
Ovine COX-2, IC50: 0.84 μM
 99.96%
Flunixin meglumine 
COX-1, IC50: 0.55 μM
COX-2, IC50: 3.24 μM
 99.71%
2,5-Di-tert-butylhydroquinone  
COX-2, IC50: 14.1 μM
 99.90%
Amfenac Sodium Hydrate  
COX-2
 99.07%
Alminoprofen  
COX-2
 99.91%
FR122047 
COX-1, IC50: 28 nM
  99.55%
Phenethyl ferulate
COX, IC50: 4.35 μM
   99.88%
Bromfenac sodium hydrate 
COX-1, IC50: 5.56 nM
COX-2, IC50: 7.45 nM
 99.94%
(+)-Catechin hydrate 
COX-1, IC50: 1.4 μM
  99.59%
Columbin 
COX-1, EC50: 327 μM
COX-2, EC50: 53.1 μM
 99.86%
Timosaponin A1  
COX-2, IC50: 36.43 μM
 99.70%
Propyphenazone
COX
   99.85%
Hydrangenol  
COX-2
 99.63%
β-Amyrone  
COX-2
 99.87%
Peonidin chloride  
COX-2
 98.70%
Valeryl salicylate 
COX-1
  ≥99.0%
α-​Chaconine  
COX-2
 99.04%
Sphondin  
COX-2
 99.70%
Lupeol acetate  
COX-2
 ≥98.0%
Phenyl β-D-glucopyranoside  
COX-2
 99.85%
Flurbiprofen axetil
COX
   99.85%
Fenofibric acid (Standard)  
COX-2
 99.16%
Acetaminophen (Standard) 
COX-1
COX-2
 99.94%
Enflicoxib  
COX-2
 99.90%
Polmacoxib  
COX-2, IC50: 0.1 μg/mL
 99.70%
Mavacoxib  
COX-2
 99.04%
Otenaproxesul 
COX-1
COX-2
 98.03%
Isoxicam 
COX-1
COX-2
 99.83%
Pelubiprofen  
COX-2
 99.27%
Iminostilbene  
COX-2
 99.34%
BW 755C 
COX-1, IC50: 0.65 μg/mL
COX-2, IC50: 1.2 μg/mL
 
Tolmetin sodium dihydrate 
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 99.94%
Nitroflurbiprofen
COX
   99.64%
Vedaprofen 
COX-1
  99.81%
Tebufelone  
COX-2
 99.52%
Teriflunomide impurity 3 
COX-1, IC50: 30 μM
  99.75%
(-)-Epicatechin gallate (Standard) 
COX-1
  
Nitroaspirin 
COX-1
  
Indomethacin-d4 
Human COX-1, IC50: 18 nM (in CHO cells)
Human COX-2, IC50: 26 nM (in CHO cells)
 99.78%
Indazole-Cl  
COX-2
 98.72%
ARN14494  
COX-2
 99.08%
Desmethyl Celecoxib  
COX-2, IC50: 32 nM
 99.42%
Pamicogrel
Cyclooxygenase
   99.44%
Floctafenine 
COX-1
COX-2
 
GW-406381  
COX-2
 99.69%
(-)-Epicatechin (Standard) 
COX-1
  
Anemarsaponin B  
COX-2
 
Hamaudol 
COX-1, IC50: 0.3 mM
COX-2, IC50: 0.57 mM
 99.59%
Shizukaol B  
COX-2
 
Cimicoxib  
COX-2
 98.02%
Madecassic acid (Standard)  
COX-2
 
3,9-Dihydroeucomin  
COX-2
 
SC57666  
COX-2, IC50: 26 nM
 98.94%
FR-188582  
COX-2, IC50: 17 nM
 99.12%
Plantanone B 
Ovine COX-1, IC50: 21.78±0.2 μM
Ovine COX-2, IC50: 44.01±0.42 μM
 99.16%
RWJ 63556  
COX-2
 99.35%
Ketoprofen (lysinate) 
COX-1, IC50: 2 nM
COX-2, IC50: 26 nM
 
COX-2-IN-6  
COX-2
 98.80%
Aspirin lithium 
COX-1
COX-2
 
Ocarocoxib  
COX-2
 99.94%
Indomethacin sodium 
COX-1, IC50: 18 nM
COX-2, IC50: 26 nM
 
COX-2-IN-28 
COX-1, IC50: 13.21 μM
COX-2, IC50: 0.054 μM
 
Tolmetin sodium 
Human COX-1, IC50: 0.35 μM
Human COX-2, IC50: 0.82 μM
 
Jaceosidin (Standard)  
COX-2
 
Daturaolone 
COX-1
  
Antitumor agent-77  
COX-2
 
COX-1-IN-1 
COX-1, IC50: 0.23 μM
COX-2, IC50: 50 μM
 
COX-2/LOX-IN-1  
COX-2, IC50: 0.55 μM
 
COX-1/2-IN-2 
COX-1, IC50: 9.7±0.09 μM
COX-2, IC50: 4.6±1.45 μM
 
Topo I/COX-2-IN-2  
COX-2, IC50: 2.31 μM
 
TX-1123 
COX-1, IC50: 15.7 μM
COX-2, IC50: 1.16 nM
 
COX-2-IN-21 
COX-1, IC50: 12.4 μM
COX-2, IC50: 0.039 μM
 
Longiferone B  
COX-2
 
COX-2-IN-27 
COX-1, IC50: 13.22 μM
COX-2, IC50: 0.045 μM
 
LM-4108 
Ovine COX-1, IC50: >66 μM
Human COX-2, IC50: 60 nM
 
STAT1/3-IN-1  
COX-2
 
COX-2-IN-5  
COX-2, IC50: 0.65 μM
 
Ginsenoside Rb3 (Standard)  
COX-2
 
COX-2-IN-17 
COX-1, IC50: >10 μM
COX-2, IC50: 0.02 μM
 
VI-60  
COX-2
 
Ginsenoside C-K (Standard)  
COX-2
 
COX-2/15-LOX-IN-6  
COX-2, IC50: 0.201 μM
 
Antitumor agent-78  
COX-2
 
COX-2-IN-51  
COX-2, IC50: 70.7 nM
 
LY256548
Cyclooxygenase
   
Ginsenoside Rd (Standard)  
COX-2
 
Heterophdoid A  
COX-2
 
COX-2-IN-47  
COX-2, IC50: 0.03 μM
 
iNOS/COX-2-IN-1  
COX-2
 
COX-1/2-IN-1 
COX-1, IC50: 9.7±0.09 μM
COX-2, IC50: 4.6±1.45 μM
 
COX-2-IN-46  
COX-2, IC50: 87.74 nM
 
COX-2-IN-31 
COX-1, IC50: 12.5 μM
COX-2, IC50: 60 nM
 
COX-2-IN-10  
COX-2
 
Clematomandshurica saponin B  
COX-2
 
Kadsulignan N  
COX-2
 
COX-2/sEH-IN-1 
COX-1, IC50: 8.72 μM
COX-2, IC50: 1.24 μM
 
Meloxicam sodium 
COX-1, IC50: 36.6 μM
COX-2, IC50: 0.49 μM
 
COX-2-IN-48  
Human COX-2, IC50: 51.7 nM
 
COX-2-IN-30 
COX-1, IC50: 10.4 μM
COX-2, IC50: 49 nM
 
(S)-(+)-Ibuprofen-d3 
COX-1, IC50: 2.1 μM
COX-2, IC50: 1.6 μM
 98.87%
Oxaprozin potassium 
COX-1, IC50: 2.2 μM
COX-2, IC50: 36 μM
 
Taraxerol acetate 
COX-1, IC50: 116.3 μM
COX-2, IC50: 94.7 μM
 
COX-2-IN-16  
COX-2, IC50: 102 μM
 
EGFR/COX-2-IN-1 
COX-1, IC50: 20.1 μM
COX-2, IC50: 1.52 μM
 
COX-2-IN-14  
COX-2
 
Ermanin  
COX-2
 
COX-1/2-IN-3 
COX-1
COX-2
 
COX-2/PI3K-IN-2  
COX-2, Ki: 3.02 nM
 
Lucidone  
COX-2
 
COX-2-IN-35  
COX-2, IC50: 4.37 nM
 
COX-1/2-IN-8 
COX-1, IC50: 2.14 ± 0.0 μM
COX-2, IC50: 0.58 ± 0.0 μM
 
Pifoxime 
COX-1
COX-2
 
COX-2-IN-32  
COX-2
 
WYZ90 
COX-1, IC50: 5734 nM
COX-2, IC50: 75 nM
 
Bromfenac 
Human COX-1, IC50: 5.56 nM
Human COX-2, IC50: 7.45 nM
 
Loxoprofen sodium (dihydrate) 
COX-1, IC50: 6.5 μM (in human whole blood)
COX-2, IC50: 13.5 μM (in human whole blood)
 
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone 
COX-1
COX-2
 99.64%
COX-1-IN-2 
COX-1, IC50: 38.76 nM
  
COX-2-IN-19 
COX-1, IC50: 117.8 μM
COX-2, IC50: 1.76 μM
 
COX-2-IN-52 
COX-1, IC50: 15.98 μM
COX-2, IC50: 54 nM
 
COX-2/15-LOX-IN-1 
COX-1, IC50: 10.65 μM
COX-2, IC50: 0.075 μM
 
COX-2-IN-34  
COX-2, IC50: 0.42 μM
 98.87%
Anti-inflammatory agent 78 
COX-1
COX-2
 
COX-2-IN-40  
COX-2, IC50: 14.86 μM
 
COX-2-IN-29 
COX-1, IC50: > 10 μM
COX-2, IC50: 0.005 μM
 
Mefenamic acid-d4 
hCOX-1, IC50: 40 nM
hCOX-2, IC50: 3 nM
 ≥98.0%
COX-2-IN-42  
COX-2
 
(±)-Aiphanol 
COX-1, IC50: 1.9 μM
COX-2, IC50: 9.9 μM
 
Balanophonin  
COX-2
 
BMP-4  
COX-2
 
COX-2-IN-23 
COX-1, IC50: 20.14 μM
COX-2, IC50: 0.28 μM
 
Anti-inflammatory agent 20  
COX-2
 
COX-2-IN-20 
COX-1, IC50: 19.3 μM
COX-2, IC50: 17.9 nM
 
Flunixin 
COX-1, IC50: 0.55 μM
COX-2, IC50: 3.24 μM
 
COX-2-IN-22  
COX-2, IC50: 8.6 μM
 
COX-2/NLRP3-IN-1  
COX-2, IC50: 1.53 μM
 
COX-2-IN-43 
COX-1, IC50: 0.983 μM
COX-2, IC50: 0.247 μM
 
MCI  
COX-2, IC50: 1.23 μM
 
Axinelline A 
COX-1, IC50: 8.89 μM
COX-2, IC50: 2.22 μM
 
L 748780 
COX-1, IC50: > 100 μM
COX-2, IC50: 0.5 μM
 
COX-2-IN-26 
COX-1, IC50: 10.61 μM
COX-2, IC50: 0.067 μM
 
20(S)-Ginsenoside Rg3 (Standard)  
COX-2
 
Anti-inflammatory agent 56  
COX-2
 
LY 178002
Cyclooxygenase
   
15-LOX-IN-2 
COX-1, IC50: 7.510 μM
COX-2, IC50: 0.190 μM
 
COX-2/PI3K-IN-1  
COX-2, Ki: 3.24 nM
 
Timegadine
COX, IC50: 5 nM (in rabbit platelets)
COX, IC50: 20 μM (in rat brain)
   
Eltenac 
COX-1, IC50: 0.03 μM
COX-2, IC50: 0.03 μM
 
Cudraflavone B 
COX-1
COX-2
 
AChE-IN-82 
COX-1, IC50: 60.41 μM
COX-2, IC50: 0.187 μM
 
Akt/NF-κB/MAPK-IN-1  
COX-2
 
Nimesulide-d5  
COX-2, IC50: 0.07-70 μM
 
COX-2-IN-49  
COX-2, IC50: 2.671 μM
 
PYZ18  
COX-2, IC50: 7.07 μM
 
Avicularin (Standard)  
COX-2
 
COX-2-IN-44 
COX-1, IC50: 1.14 μM
COX-2, IC50: 0.18 μM
 
COX-2-IN-24  
COX-2, IC50: 0.17 μM
 
COX-2/5-LOX-IN-3 
COX-1, IC50: 45.73 μM
COX-2, IC50: 5.45 μM
 
Akt/NF-κB/JNK-IN-1  
COX-2
 
RS-57067  
COX-2, Ki: 16.9 μM
 
NCX 466 
COX-1
COX-2
 
Indomethacin N-octyl amide 
COX-1, IC50: 66 μM
COX-2, IC50: 0.04 μM
 
BF389 
COX-1, IC50: 4 μg/mL
COX-2, IC50: 8 μg/mL
 
Fenoprofen Calcium
COX
   
COX-1/2-IN-9 
COX-1, IC50: 0.031 μM
COX-2, IC50: 0.010 μM
 
Multinoside A  
COX-2
 
Tenidap sodium 
COX-1
COX-2
 
4-Desmethyl-2-methyl celecoxib  
COX-2, IC50: 0.069 μM
 
LFS-1107  
COX-2
 
ZLJ-6 
COX-1, IC50: 0.73 μM
COX-2, IC50: 0.31 μM
 
Flosulide  
COX-2
 
Thioflosulide  
COX-2, IC50: 2.3 nM
 
S-2474 
COX-1, IC50: 27 μM
COX-2, IC50: 11 nM
 
Catechin hydrate 
COX-1, IC50: 1.4 μM
  
N1-Acetyl-5-methoxykynuramine hydrochloride  
COX-2
 
COX-2-IN-1  
COX-2, IC50: 3.9 μM
 
COX-2-IN-2  
COX-2, IC50: 240 nM
 99.53%
Tilmacoxib  
Human COX-2, IC50: 85 nM
 ≥99.0%
COX/5-LO-IN-1
COX
   
SC58451  
COX-2