1. Gene
  2. CAMP - cathelicidin antimicrobial peptide Gene

CAMP - cathelicidin antimicrobial peptide Gene

Homo sapiens

Also known as LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39

Gene ID: 820 | Gene type: protein coding

About CAMP

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,223,495-48,225,485 (from NCBI)

This gene has 2 transcripts (splice variants) and 249 orthologues. Restricted expression toward bone marrow (RPKM 591.5).

Summary

This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. The protein plays an important role in innate immunity defense against viruses. In addition to its Antibacterial, Antifungal, and Antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2021]

CAMP Products(1)

mRNA Protein Name
NM_004345.5 NP_004336.4 cathelicidin antimicrobial peptide preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
31818937 GOA
Biological Process GO Annotation Evidence Reference Source
involved in amyloid fibril formation EXP
EXP: Inferred from Experiment
32753597 GOA
involved in amyloid fibril formation IDA
IDA: Inferred from direct assay
32753597 GOA
involved in antibacterial humoral response IDA
IDA: Inferred from direct assay
7529412 GOA
involved in antifungal humoral response IDA
IDA: Inferred from direct assay
14978112 GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
7529412 GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: Inferred from mutant phenotype
17012259 GOA
involved in chronic inflammatory response IMP
IMP: Inferred from mutant phenotype
9182550 GOA
involved in cytolysis EXP
EXP: Inferred from Experiment
9452503 GOA
involved in cytolysis by host of symbiont cells IDA
IDA: Inferred from direct assay
20421939 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
7529412 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
7529412 GOA
involved in defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
17012259 GOA
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
21115716 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
7529412 GOA
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
17012259 GOA
involved in innate immune response in mucosa IDA
IDA: Inferred from direct assay
12860195 GOA
acts upstream of or within killing by host of symbiont cells IDA
IDA: Inferred from direct assay
16177355 GOA
involved in killing by host of symbiont cells IDA
IDA: Inferred from direct assay
16020269 GOA
involved in modulation of process of another organism IDA
IDA: Inferred from direct assay
23537644 GOA
involved in neutrophil activation IDA
IDA: Inferred from direct assay
22879591 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
14978112 GOA
involved in response to yeast IDA
IDA: Inferred from direct assay
14978112 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
12759353 GOA
located in specific granule IDA
IDA: Inferred from direct assay
12759353 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMP Protein Structure

Cathelicidins

Cathelicidins: Cathelicidin (33 - 98)

CAP18_C

CAP18_C: LPS binding domain of CAP18 (C terminal) (136 - 163)

  • 0
  • 100
  • 170 a.a.
Protein Preferred Names Protein Names

cathelicidin antimicrobial peptide

18 kDa cationic antimicrobial protein

Related Diseases

Diseases Alias
Rosacea

Erythematotelangiectatic Rosacea

Papulopustular Rosacea

Phymatous Rosacea

Acne Roscea

Acne, Erythematosa

Granulomatous Rosacea

Ocular Rosacea

Acne Rosacea

Hypertrophic Rosacea

Cellulitis
Facial Dermatosis

Facial Dermatoses

Mycobacterium Marinum

Mycobacterium Marinum Infection

Fish Tank Granuloma

M. Marinum

Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Severe Congenital Neutropenia 3

Kostmann Syndrome

Infantile Agranulocytosis

Kostmann Disease

Scn3

Severe Congenital Neutropenia Type 3

Hidradenitis Suppurativa

Acne Inversa

Suppurative Hidradenitis

Acne Inversa, Familial

Apocrinitis

Hidradenitides, Suppurative

Hidradenitis, Suppurative

Suppurative Hidradenitides

Inverse Acne

Hidradenitis

Hydradenitis

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Psoriasis
Necrotizing Fasciitis

Fasciitis, Necrotizing

Coffin-Lowry Syndrome

CLS

Coffin Syndrome 1

Coffin Syndrome

Intellectual Disability With Osteocartilaginous Abnormalities

Dwarfism, Lean Spastic Type

Lean Spastic Dwarfism

Mental Retardation With Osteocartilaginous Abnormalities

Coffin Lowry Syndrome

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Papillon-Lefevre Syndrome

Papillon-Lefevre Disease

Papillon-Lefèvre Syndrome

PLS

Keratosis Palmoplantaris With Periodontopathia

PALS

Papillon Lefevre Syndrome

Keratosis Palmoplantar-Periodontopathy Syndrome

Papillon-Lefvre Syndrome

Hyperkeratosis Palmoplantaris With Periodontosis

Keratoris Palmoplantaris With Periodontopathia

Keratosis Palmoplantar - Periodontopathy

Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction

Palmoplantar Keratoderma With Periodontosis

Palsy

Toxic Shock Syndrome

Septic Shock

Toxic Shock

Tss

Shock, Septic

Staphylococcal Toxic Shock Syndrome

Tss - [Toxic Shock Syndrome]

Eczema Herpeticum

Herpes Simplex Dermatitis

Herpes Simplex Eyelid Dermatitis

Kaposi Varicelliform Eruption

Herpes Simplex Dermatitis Of Eyelid

Herpes Simplex Virus Dermatitis

Herpes Simplex Virus Eyelid Dermatitis

Denture Stomatitis

Stomatitis, Denture

Denture Sore Mouth

Autoimmune Disease Of Skin And Connective Tissue
Impetigo
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant

Sebaceous Gland Disease

Sebaceous Gland Anomaly

Sebaceous Gland Diseases

Vaginal Disease

Vaginal Diseases

Shigellosis

Dysentery, Bacillary

Bacillary Dysentery

Shigella Boydii Infectious Disease

Shigella Flexneri Infectious Disease

Shigella Gastroenteritis

Shigella Sonnei Infectious Disease

Shigella Infections

Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB

Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact

Chancroid

Ulcus Molle, Skin

Chancroids

Bubo Due To Haemophilus Ducreyi

Soft Chancre

Ulcus Molle

Vaginitis

Infective Vaginitis

Inflammation Of Vagina

Colpitis

Vaginal Inflammation

Vaginitis Nos

Fallopian Tube Disease

Fallopian Tube Diseases

Tinea Pedis

Athlete'S Foot

Dermatophytosis Of Foot

Ringworm Of Foot

Moccasin Foot

Dermatophytosis

Tinea

Dermatophytosis, Unspecified

Ringworm

Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

Cutaneous Mycosis

Dermal Mycosis

Superficial Mycosis, Unspecified

Fungus Infection Of Skin

Skin Mycosis

Dermatitis Fungoid

Fungal Dermatitis

Fungal Dermatosis

Mycotic Infection Of Skin

Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Endocardium Disease
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Urethritis

Nonspecific Urethritis

Non-Gonococcal Urethritis

Nongonococcal Urethritis

Gingival Disease

Gingival Diseases

Gum Disease

Gingival Disorder

Gingivitis And Periodontal Diseases

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Telangiectasis

Telangiectasia

Urinary Tract Infection

Urinary Tract Infections

Uti

Urinary Tract Infection Nos

Uti - [Urinary Tract Infection]

Uti Nos - [Urinary Tract Infection Nos]

Urosepsis Nos

E Coli Uti

E Coli Urinary Tract Infection

Escherichia Coli Uti

Severe Congenital Neutropenia

Congenital Neutropenia

Neutropenia, Severe Congenital

Congenital Agranulocytosis

Infantile Genetic Agranulocytosis

Kostmann Disease

Kostmann'S Agranulocytosis

Kostmann'S Syndrome

Severe Infantile Genetic Neutropenia

Scleredema Adultorum

Scleredema

Buschke'S Scleredema

Scleredema Adultorum Of Buschke

Scleredema Diabeticorum

Scleredema Diabeticorum Of Buschke

Buschke Scleredema

Integumentary System Disease
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Primary Bacterial Infectious Disease
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease

Arpkd

Polycystic Kidney Disease, Autosomal Recessive

Polycystic Kidney And Hepatic Disease 1

Pkhd1

PKD4

Polycystic Kidney Disease 4 With Or Without Hepatic Disease

Polycystic Kidney Disease, Infantile, Type I

Polycystic Kidney Disease, Infantile Type

Polycystic Kidney, Autosomal Recessive

Pkd3, Formerly

Polycystic Kidney Disease 4, With Or Without Hepatic Disease

Arpkd/Chf

Ar-Pkd

Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease

Infantile Polycystic Kidney Disease Type I

Pkd3

Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease

Polycystic Kidney Disease 3, Autosomal Dominant

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus CAMP VGNC VGNC:60340
Mus musculus CAMP MGD MGI:108443
Canis familiaris CAMP VGNC VGNC:38688
Macaca mulatta CAMP VGNC VGNC:84221
Rattus norvegicus CAMP RGD RGD:1559878
Macaca fascicularis CAMP NCBI NCBI:102139204
Others CAMP NCBI