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Isoforms Recommended:	AChE

Results for "

AChE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (8) Adrenergic Receptor (2) Aldehyde Dehydrogenase (ALDH) (1) Amylases (1) Amyloid-β (38) Antibiotic (1) Apoptosis (15) Autophagy (1) Bacterial (14) Beta-lactamase (1) Beta-secretase (13) Calcium Channel (1) Cannabinoid Receptor (1) Carbonic Anhydrase (7) CCR (1) CDK (2) Chemerin Receptor (1) Cholinesterase (ChE) (430) COX (3) Cytochrome P450 (1) Dopamine Receptor (4) Drug Metabolite (2) DYRK (1) Endogenous Metabolite (7) Enterovirus (2) Epoxide Hydrolase (2) ERK (1) Fungal (5) GABA Receptor (1) Glucosidase (3) GSK-3 (4) HBV (2) HDAC (3) Histamine Receptor (3) Histone Acetyltransferase (1) iGluR (7) Interleukin Related (3) Isotope-Labeled Compounds (15) JNK (2) Keap1-Nrf2 (3) mAChR (5) Microtubule/Tubulin (2) MMP (2) Monoamine Oxidase (33) nAChR (5) NF-κB (1) NO Synthase (2) NOD-like Receptor (NLR) (1) Opioid Receptor (2) P-glycoprotein (3) p38 MAPK (1) Parasite (15) Phosphatase (3) Phosphodiesterase (PDE) (2) Potassium Channel (1) PPAR (1) Reactive Oxygen Species (7) ROS Kinase (4) Serotonin Transporter (1) Small Interfering RNA (siRNA) (3) Sodium Channel (1) Tau Protein (1) TNF Receptor (3) Toll-like Receptor (TLR) (1) Topoisomerase (2)
By Research Areas:	Cancer (48) Cardiovascular Disease (5) Endocrinology (1) Infection (30) Inflammation/Immunology (49) Metabolic Disease (26) Neurological Disease (360)
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455

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

125

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Products

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Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2860

Acetylcholinesterase, Fly head AChE; EC 3.1.1.7	Cholinesterase (ChE)	Neurological Disease
Acetylcholinesterase, Fly head (ACHE; EC 3.1.1.7) is a cholinergic enzyme mainly found in neuromuscular junctions and cholinergic type chemical synapses used in biochemical research. Acetylcholinesterase, Fly head catalyzes the breakdown or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetate and choline. Acetylcholinesterase, Fly head's main role is to terminate neuronal transmission and signaling between synapses to prevent ACh spread and activation of nearby receptors .

HY-W077226

AChE-IN-23	Cholinesterase (ChE)	Neurological Disease
AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 48.3 μM .

HY-156372

AChE-IN-44	Cholinesterase (ChE)	Neurological Disease
AChE-IN-44 (Compound Tap4) is an *AChE* inhibitor. AChE-IN-44 can be converted into the thiazole salt AChE inhibitor Tat2 .

HY-156356

AChE-IN-42	Cholinesterase (ChE)	Neurological Disease
AChE-IN-42 (Compound 28) is an *AChE* inhibitor (K_i: 0.44?μM) .

HY-150728

AChE-IN-22	Cholinesterase (ChE)	Neurological Disease
AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against *AChE* and BuChE with the IC₅₀ values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer's disease .

HY-162933

AChE-IN-77	Cholinesterase (ChE)	Metabolic Disease
AChE-IN-77 (5d) is a potent *AChE* and BACE1 inhibitor, with IC₅₀ values of 29.46 µM ans 2.85 µM for AChE and BACE1 in vitro metal chelating ability against Fe ³⁺ .

HY-115919

AChE-IN-8	Cholinesterase (ChE)	Neurological Disease
AChE-IN-8 (Compound 19) is a potent inhibitor of *AChE* with an IC₅₀ of 1.95 μM. AChE-IN-8 has the potential for the research of Alzheimer's disease .

HY-144753

AChE/BChE-IN-2	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-2 (Compound 13b) is a potent inhibitor of *AChE/BChE* (AChE IC50 = 0.96 ± 0.14 µM, BChE IC50 = 1.23 ± 0.23 µM). AChE/BChE-IN-2 has the potential for the research of AD diseases .

HY-161311

AChE/BChE-IN-18	Cholinesterase (ChE) Cannabinoid Receptor	Neurological Disease
AChE/BChE-IN-18 (Compound 4g) is a *dual inhibitor of AChE/BChE* , with a IC₅₀ value of 0.315 μM for AchE. AChE/BChE-IN-18 is also a CB2R antagonist with a K_i value of 31 nM. AChE/BChE-IN-18 has neuroprotective activity .

HY-155345

AChE-IN-45	Cholinesterase (ChE)	Neurological Disease Cancer
AChE-IN-45 (Compound 14) is an acetylcholinesterase (AChE) inhibitor with IC₅₀ of 11.57±0.45 nM that shows antioxidant and neuroprotective activities .

HY-157087

AChE/MAO-B-IN-4	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE/MAO-B-IN-4 (compound 4a) is a selective dual *AChE* and MAO-B inhibitor. AChE/MAO-B-IN-4 shows no significant inhibition activity against BChE and h-MAO-A. AChE/MAO-B-IN-4 can be used for the Alzheimer’s disease (AD) research .

HY-156358

AChE-IN-43	Cholinesterase (ChE)	Neurological Disease
AChE-IN-43 is a potent and selective inhibitor of *AChE* with a K_i of 0.41 μM. AChE-IN-43 can be used in study neurological disease .

HY-157981

AChE-IN-60	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE-IN-60 (compound 6k) is a potant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor with IC₅₀s of 27 nM and 43 nM, respectively. AChE-IN-60 also inhibits monoamine oxidase (MAO)-A and MAO-B with IC₅₀s of 353 nM and 716 nM, respectively .

HY-147952

AChE-IN-20	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
AChE-IN-20 (compound M26) is a potent *AChE* inhibitor with IC₅₀ value of 397.32 nM and with K_i value of 335.76 nM. AChE-IN-20 shows inhibition potency against hCA I , hCA II and α-GLY with IC₅₀ values of 84.14, 69.24 and 52.08 nM and with K_i values of 97.86, 76.23 and 57.93 nM, respectively .

HY-115973

AChE-IN-11	Cholinesterase (ChE)	Neurological Disease
AChE-IN-11 (compound 5C) is a triple inhibitor targeting *AChE/MAO-B/BACE1* (IC₅₀=7.9 μM, 9.9 μM, 8.3 μM, respectively) and a selective metal ion chelators. AChE-IN-11 exhibits mixed AChE inhibitory effects, binding to both CAS and PAS of AChE. AChE-IN-11 also exhibits good antioxidant activity (ORAC=2.5 eq) and potential neuroprotective effects in Alzheimer's disease .

HY-151152

AChE-IN-24	Cholinesterase (ChE)	Neurological Disease
AChE-IN-24 is a potent *AChE* inhibitor and can penetrate the BBB. AChE-IN-24 has the mighty inhibitory activity to hAChE with an IC₅₀ value of 0.053 μM. AChE-IN-24 can be used for the research of Alzheimer s disease (AD) .

HY-144775

AChE-IN-10	Cholinesterase (ChE)	Neurological Disease
AChE-IN-10 (Compound 24r) is a potent inhibitor of *AChE* (IC₅₀ = 2.4 nM). AChE-IN-10 potently inhibits AChE, reduces tau phosphorylation at S396 residue, provides neuroprotection by rescuing neuronal morphology and increasing cell viability. AChE-IN-10 is also found to reduce amyloid aggregation in the presence of AChE .

HY-163780

AChE-IN-66	Parasite	Infection
Nematicidal agent 1 is a potent nematicidal agent. Nematicidal agent 1 binds to the pocket of acetylcholine esterase (AChE) .

HY-W003576

ACHE-IN-38 hydrochloride	Others	Neurological Disease
ACHE-IN-38 hydrochloride (Compound 13b) inhibits the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviates memory deficits in patients with Alzheimer’s Disease by potentiating cholinergic transmission .

HY-157089

AChE/MAO-B-IN-5	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/MAO-B-IN-5 is a dual inhibitor of *AChE* and MAO-B. AChE/MAO-B-IN-5 can used in study Alzheimer’s disease .

HY-W415004

ACHE-IN-38	Others	Neurological Disease
ACHE-IN-38 (Compound mol-8) inhibits the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviates memory deficits in patients with Alzheimer’s Disease by potentiating cholinergic transmission .

HY-146039

AChE-IN-15	Cholinesterase (ChE)	Neurological Disease
AChE-IN-15 (Compound 3d) is a reversible human acetylcholinesterase (huAChE) (IC₅₀=6.8 μM) and human butyrylcholinesterase (huBChE) (IC₅₀=16.1 μM) inhibitor. AChE-IN-15 shows significant antioxidant potency, AChE-IN-15 can be used for the research of Alzheimer’s disease .

HY-144660

AChE-IN-7	Cholinesterase (ChE)	Neurological Disease
AChE-IN-7 (Compound 16) is a selective and potent inhibitor of acetylcholinesterase (eeAChE IC₅₀ = 0.045 μM; eeBuChE IC₅₀ = 19.68 μM). AChE-IN-7 is safe in vivo and in vitro, and shows good overall pharmacokinetic performance and high bioavailability (F = 55.5%). AChE-IN-7 also has high BBB permeability .

HY-152114

AChE/BChE/MAO-B-IN-4	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/BChE/MAO-B-IN-4, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC₅₀ of 0.0393 μM for human MAO-B. AChE/BChE/MAO-B-IN-4 is a potent *AChE* and BChE enzyme inhibitor, with IC₅₀s of 0.0458 μM and 0.075 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-4 shows significant antioxidant activity and prevent β-amyloid plaque aggregation. AChE/BChE/MAO-B-IN-4 has the potential for Alzheimer's disease (AD) research .

HY-149012

AChE/hCA I/II-IN-1	Cholinesterase (ChE) Carbonic Anhydrase	Neurological Disease Endocrinology
AChE/hCA I/II-IN-1 (Compound 6) is a potent inhibitor of *AChE/Hca* with IC₅₀ values of 22.21, 60.79 and 66.64 nM for AChE, Hca Ⅰ and Hca Ⅱ. AChE/hCA I/II-IN-1 can be used for the rsearch for glaucoma, Alzheimer's disease, diabetes .

HY-152112

AChE/BChE/MAO-B-IN-2	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/BChE/MAO-B-IN-2 is a potent *AChE, BChE, and MAO-B* enzymes inhibitor with IC₅₀ values of 48.2 nM, 83.9 nM, and 31.2 nM, respectively. AChE/BChE/MAO-B-IN-2 has significant antioxidant activity, and can be used for Parkinson’s disease research .

HY-152113

AChE/BChE/MAO-B-IN-3	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC₅₀ of 0.0359 μM for human MAO-B. AChE/BChE/MAO-B-IN-3 is a potent *AChE* and BChE enzyme inhibitor, with IC₅₀s of 0.0473 μM and 0.0782 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-3 shows significant antioxidant activity and has the potential for Alzheimer's disease (AD) research .

HY-144324

AChE-IN-6	Cholinesterase (ChE)	Neurological Disease
AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC₅₀ = 0.20 μM; HuAChE, IC₅₀ = 37.02 nM) and anti-Aβ activity (IC₅₀ = 1.92 μM for self-induced Aβ1-42 aggregation; IC₅₀ = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC₅₀ = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC₅₀ = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils). AChE-IN-6 has the potential for the research of Alzheimer's disease .

HY-146035

AChE-IN-14	Cholinesterase (ChE) Histamine Receptor	Neurological Disease
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC₅₀s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H₃ receptor (H₃R; K_i= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease .

HY-159081

AChE/BChE-IN-20	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-20 (compound 3m) is an acetylcholinesterase (AChE, IC₅₀=34.81 µM) and butylcholinesterase (BChE, IC₅₀=20.66 µM) inhibitor, which has been demonstrated to have affinity for key enzyme pockets and favorable interaction profiles by molecular docking and kinetic simulations, and can be used in the study of Alzheimer's disease .

HY-144392

AChE/BuChE-IN-1	Cholinesterase (ChE)	Neurological Disease
AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC₅₀ of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC₅₀ of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC₅₀ of 0.1674 μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ_1-42 aggregation (self-, Cu₂₊-induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has the potential for Alzheimer' disease (AD) research .

HY-151260

AChE/BACE1/GSK3β-IN-1	Beta-secretase Cholinesterase (ChE) GSK-3	Neurological Disease
AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of *AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC₅₀* values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD) .

HY-157532

AChE-IN-55	Cholinesterase (ChE)	Others
AChE-IN-55, 1,2,3-Triazole oxime derivative, is an inhibitor of AChE(4.8 μM) .

HY-164130

AChE-IN-65	Cholinesterase (ChE)	Neurological Disease
AChE-IN-65 (Compound DABA_1) is a mixed inhibitor for acetylcholinesterase (AChE), with a K_i of 556.4 μM for Electrophorus electricus AChE.

HY-159173

AChE-IN-71	Cholinesterase (ChE)	Neurological Disease
AChE-IN-71 (compound 12A) is a *AChE* inhibitor. AChE-IN-71 can be used in the study of Alzheimer’s disease .

HY-162258

AChE-IN-57	Cholinesterase (ChE)	Neurological Disease
AChE-IN-57 (compound 5b(SP-2)) is a potent *AChE* inhibitor. AChE-IN-57 improves cognitive defects. AChE-IN-57 restores the biochemical mediators and inhibits reactive oxygen and nitrogen species implicated in the neuroinflammation mechanism. AChE-IN-57 has the potential for the research of Alzheimer .

HY-156030

AChE-IN-40	Cholinesterase (ChE)	Neurological Disease
AChE-IN-40 (Compound 5C) is an *AChE* inhibitor (IC₅₀: 120 nM). AChE-IN-40 can be used for research of Alzheimer's disease .

HY-149473

AChE-IN-39	Cholinesterase (ChE)	Neurological Disease
AChE-IN-39 (Compound 7c) is an *AChE* inhibitor (IC₅₀: 0.058 μM). AChE-IN-39 has DPPH scavenging activity. AChE-IN-39 improves the cognitive impairment in AlCl₃-induced amnesia animal model. AChE-IN-39 can be used for research of Alzheimer's disease .

HY-161842

AChE-IN-67	Cholinesterase (ChE)	Neurological Disease
AChE-IN-67 (compound 8n) is a potent *AChE* inhibitor, with an IC₅₀ of 0.033 μM. AChE-IN-67 exhibits activity similar to Donepezil (HY-14566). AChE-IN-67 exhibits high blood-brain barrier (BBB) permeability. AChE-IN-67 can be used for Alzheimer's disease research .

HY-162005

AChE-IN-48	Cholinesterase (ChE)	Neurological Disease
AChE-IN-48 (compound 16) is *AChE* inhibitor ,with the IC₅₀ of 41.87 μM. AChE-IN-48 can be used for Alzheimer's disease study .

HY-162915

AChE-IN-75	Cholinesterase (ChE)	Neurological Disease
AChE-IN-75 (N-(2′-methyl)allylnorgalanthamine) is an *AChE* inhibitor. AChE-IN-75 can be used in Alzheimer's disease research .

HY-155713

AChE-IN-34	Cholinesterase (ChE)	Neurological Disease
AChE-IN-34 (compound 5l) is a potent and selective *AChE* inhibitor with an IC₅₀ value of 3.98 µM with no significant inhibition against BChE. AChE-IN-34 inhibits AChE with a Ki of 0.044 μM in a mixed mode (Acetylthiocholine substrate; 0.1-1 mM) .

HY-157296

AChE-IN-47	Cholinesterase (ChE)	Neurological Disease
AChE-IN-47 (compound g17) is a *AChE* inhibitor with the IC₅₀ of 0.24 μM. AChE-IN-47 inhibits amyloid β peptides self-aggregation. AChE-IN-47 displays neuroprotective effects and effectively suppresses the intracellular accumulation of reactive oxygen species .

HY-151370

AChE-IN-26	Cholinesterase (ChE)	Neurological Disease
AChE-IN-26 (compound 4a) is an *AChE* (acetylcholinesterase) inhibitor with an IC₅₀ value of 0.42 μM. AChE-IN-26 can be used for the research of Alzheimer’s disease .

HY-N12388

AChE-IN-46	Cholinesterase (ChE)	Neurological Disease
AChE-IN-46 (compound 4), a β-cyclocostunolide, is an *AChE* inhibitor .

HY-162693

AChE-IN-68	Cholinesterase (ChE)	Neurological Disease
AChE-IN-68 (compound 2l) is a potent and selective *AChE* inhibitor, with an IC₅₀ value of 0.040 μM. AChE-IN-68 has high blood-brain barrier permeability. AChE-IN-68 can be used for the research of neurodegenerative disorders, particularly Alzheimer’s disease .

HY-151338

AChE-IN-25	Cholinesterase (ChE)	Neurological Disease
AChE-IN-25 is a potent, selective and uncompetitive acetylcholinesterase (AChE) inhibitor (IC₅₀=2.95 µM). AChE-IN-25 can be used in Alzheimer's disease research .

HY-159116

AChE-IN-69	Cholinesterase (ChE)	Neurological Disease
AChE-IN-69 (compound 7o) is a potent *AChE* inhibitor with an IC₅₀ value of 1.67 µM. AChE-IN-69 has the potential for the research of Alzheimer’s disease .

HY-159148

AChE-IN-70	Cholinesterase (ChE)	Others
AChE-IN-70 (compound 4) is a *AChE* inhibitor. AChE-IN-70 shows larvicidal activity against mosquito larvae (Culex pipiens L.). and can be used for study of mosquito control .

HY-161243

AChE-IN-56	Cholinesterase (ChE)	Neurological Disease
AChe-IN-56 is an orally active inhibitor for acetylcholinesterase enzyme (AChE) with neuroprotective efficacy .

Cat. No.	Product Name

HY-L013

Neuronal Signaling Compound Library

2,803 compounds

Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.

MCE designs a unique collection of 2,803 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Cat. No.	Product Name	Type

HY-W324391

Coumarin 106 Coumarin 478	Dyes
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC₅₀=4.97 and K_i=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC₅₀=4.56) .

HY-103373

PE154	Fluorescent Dyes/Probes
PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC₅₀s=280 pM and 16 nM, respectively) . PE154 can label β-amyloid plaques in histochemical analysis .

Cat. No.	Product Name	Type

HY-21629

N-Boc-4-piperidinemethanol	Cell Assay Reagents
N-Boc-4-piperidinemethanol (compound 4) is an acetylcholinesterase (AChE) inhibitor. N-Boc-4-piperidinemethanol can used ti study Alzheimer’s Disease .

Cat. No.	Product Name	Target	Research Area

HY-W014700

Glycyl-L-glutamic acid	Cholinesterase (ChE)	Neurological Disease
Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of *AChE* content and activity. Glycyl-L-glutamic acid doesn’t act directly on *AChE* synthesis, and may prevent preganglionic neuronal degeneration .

HY-P5797

Fasciculin-II Fas-2	Cholinesterase (ChE)	Neurological Disease
Fasciculin-II (Fas-2) is a potential inhibitor of acetylcholinesterase (AChE) .

HY-P5798

Fasciculin-I FAS-I	Cholinesterase (ChE)	Neurological Disease
Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting acetylcholinesterase (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1089

Vincosamide	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Classification of Application Fields Source classification Rubiaceae Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids	Cholinesterase (ChE)
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity .

HY-75247

Coumaran 2 Publications Verification 2,3-Dihydrobenzofuran	Structural Classification Natural Products Verbenaceae Source classification Plants Endogenous metabolite Lantana camaraLinn.	Cholinesterase (ChE) Endogenous Metabolite Parasite
Coumaran (2,3-Dihydrobenzofuran) is an *AChE* inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-N12388

AChE-IN-46	Structural Classification Natural Products Source classification Plants Compositae Inula grandis Schrenk ex Fish..	Cholinesterase (ChE)
AChE-IN-46 (compound 4), a β-cyclocostunolide, is an *AChE* inhibitor .

HY-N10701

AChE/BChE-IN-11	Structural Classification Oleaceae Syringa oblata Lindl. Source classification Plants Saccharides Monosaccharides	Cholinesterase (ChE)
AChE/BChE-IN-11 (compound 1) is a potent is a dual *AChE* and BChE inhibitor with IC₅₀ values of 70 and 71 μM for AChE and BChE, respectively. AChE/BChE-IN-11 is a natural product that could be isolated from the leaf of artichoke . AChE/BChE-IN-11 can be used in research of Alzheimer’s disease (AD) research .

HY-N12027

AChE/BChE-IN-14	Structural Classification Alkaloids Fissistigma polyanthum (Hook. f. et Thoms.) Merr. Source classification Plants Annonaceae Isoquinoline Alkaloids	Cholinesterase (ChE)
AChE/BChE-IN-14 (compound 13) is a benzylisoquinoline alkaloid isolated from the roots of Fissistigma polyanthum. AChE/BChE-IN-14 exhibits AChE and BChE inhibitions with antioxidant activities. AChE/BChE-IN-14 can be used for Alzheimer’s disease research .

HY-N12622

AChE-IN-58	Structural Classification Flavonoids Flavones Source classification Camellia sinensis (L.) O. Ktze. Plants Theaceae	Cholinesterase (ChE)
AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-58 can extend the mean lifespan, delay the Aβ₁-42-induced paralysis, enhanc the locomotion, and alleviate glutamic acid (Glu)-induced neurotoxicity of CL4176 worms .

HY-W782096

Salvianolic acid H	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Cholinesterase (ChE)
Salvianolic acid H is a potent acetylcholinesterase (AChE) inhibitor .

HY-N2912

Axillaridine A	Structural Classification Buxaceae Terpenoids Source classification Diterpenoids Sarcococca hookeriana Baill. Sarcococca hookeriana var. digyna Franch. Plants	Cholinesterase (ChE)
Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of *AChE* .

HY-119592

Cyclophostin	Structural Classification Natural Products Microorganisms Source classification	Cholinesterase (ChE)
Cyclophostin is an acetylcholinesterase (AChE) inhibitor with IC₅₀ values of 45, 0.76 and 1.3 nM for humans and two different insects, respectively .

HY-124140

Heliosupine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Heliotropium indicum L. Other Diseases Plants Disease Research Fields Boraginaceae	Cholinesterase (ChE)
Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC₅₀ 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .

HY-N7480A

Quinolactacin A1	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Neurological Disease Source classification Quinoline Alkaloids Disease Research Fields	Cholinesterase (ChE)
Quinolactacin A1 is a potent acetylcholinesterase (AChE) inhibitor from solid state fermentation of Penicillium citrinum 90648. Quinolactacin A1 can be used for the research of Alzheimer disease .

HY-N6619A

Lycoramine	Alkaloids Source classification Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Cholinesterase (ChE)
Lycoramine, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor .

HY-N2511

Trimyristin	Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite Disease Research Fields	Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-N6619

Lycoramine hydrobromide	Alkaloids other families Source classification Plants	Cholinesterase (ChE)
Lycoramine hydrobromide, a dihydro-derivative of galanthamine, is isolated from Lycoris radiate. Lycoramine hydrobromide is a potent acetylcholinesterase (AChE) inhibitor .

HY-N11711

Pumiloside	Structural Classification Alkaloids Nauclea officinalis (Pirre ex Pitard) Merr. Other Alkaloids Source classification Rubiaceae Plants Indole Alkaloids	Cholinesterase (ChE)
Pumiloside is a natural product that can be isolated from Nauclea officinalis. Pumiloside is a *AchE* inhibitor with IC₅₀ value of 118.36 μM .

HY-N12423

Bis-(-)-8-demethylmaritidine	Crinum asiaticum L. Structural Classification Alkaloids Other Alkaloids Source classification Plants Amaryllidaceae	Cholinesterase (ChE)
Bis-(-)-8-demethylmaritidine, a natural alkaloid, is a potent acetylcholinesterase (AChE) inhibitor. Bis-(-)-8-demethylmaritidine can be used for Alzheimer's disease research .

HY-124140R

Heliosupine (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Heliotropium indicum L. Source classification Plants Boraginaceae	Cholinesterase (ChE)
Heliosupine (Standard) is the analytical standard of Heliosupine. This product is intended for research and analytical applications. Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores .

HY-N2511R

Trimyristin (Standard)	Structural Classification Natural Products Microorganisms Source classification Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite	Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin (Standard) is the analytical standard of Trimyristin. This product is intended for research and analytical applications. Trimyristin, an active molluscicidal component of?Myristica fragrans?Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of?Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-N8764

Decaffeoylacteoside Decaffeoylverbascoside; Verbasoside	Structural Classification Labiatae Source classification Phenols Polyphenols Plants Ambrosia hispida	Monoamine Oxidase Cholinesterase (ChE)
Decaffeoylacteoside is an inhibitor of *AChE/BChE/LOX* with moderate activity .

HY-N4206

Leptomerine	Alkaloids other families Source classification Quinoline Alkaloids Plants	Cholinesterase (ChE)
Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC₅₀ of 2.5 μM. Anticholinesterasic activity .

HY-N2425

Rhodiosin	Flavonols Structural Classification Classification of Application Fields Crassulaceae Source classification Metabolic Disease Plants Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Flavonoids Rhodiola rosea Linn. Phenols Polyphenols Disease Research Fields	Cholinesterase (ChE)
Rhodiosin is a double inhibitor of CYP2D6 and AChE, and can be isolated from Rhodiolis rhodiolis root. The IC₅₀ for CYP2D6 is 0.761 μM, and the K_i is 0.769 μM. Rhodiosin has antioxidant and neuroprotective activity and can regulate HIF-1α signaling pathway to protect the central nervous system

HY-N2425R

Rhodiosin (Standard)	Flavonols Structural Classification Flavonoids Rhodiola rosea Linn. Crassulaceae Source classification Phenols Polyphenols Plants Rhodiola crenulata (HK. f. et.Thoms) H. Ohba	Cholinesterase (ChE)
Rhodiosin (Standard) is the analytical standard of Rhodiosin. This product is intended for research and analytical applications. Rhodiosin is a double inhibitor of CYP2D6 and AChE, and can be isolated from Rhodiolis rhodiolis root. The IC₅₀ for CYP2D6 is 0.761 μM, and the Ki is 0.769 μM. Rhodiosin has antioxidant and neuroprotective activity and can regulate HIF-1α signaling pathway to protect the central nervous system

HY-N4142

Cyanidin-3-O-galactoside chloride Ideain chloride	Cardiovascular Disease Structural Classification Anthocyans Flavonoids Classification of Application Fields Source classification Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Disease Research Fields	Cholinesterase (ChE)
Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong *AChE* inhibitory activity .

HY-122957

Huperzine C	Lycopodiaceae Alkaloids Lycopodium serratum Thunb． Source classification Plants	Cholinesterase (ChE)
Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC₅₀ of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease .

HY-N4142R

Cyanidin-3-O-galactoside chloride (Standard)	Structural Classification Anthocyans Flavonoids Source classification Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants	Cholinesterase (ChE)
Cyanidin-3-O-galactoside (chloride) (Standard) is the analytical standard of Cyanidin-3-O-galactoside (chloride). This product is intended for research and analytical applications. Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity .

HY-N8376

Fustin (±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone	Flavanonols Flavonoids Source classification Plants Rhus glabra L. Anacardiaceae	Amyloid-β mAChR Cholinesterase (ChE)
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research .

HY-N3185

N-Methylcalycinine	Structural Classification Alkaloids Other Alkaloids Source classification Stephania epigaea Lo Plants Menispermaceae	Cholinesterase (ChE)
N-Methylcalycinine is a nature product with AChE inhibitory activity. N-Methylcalycinine can be isolated from the roots of Stephania epigaea. N-Methylcalycinine can be used for the research of asthma, cancer, dysentery, fever, hyperglycemia, intestinal complaints, inflammation, sleep disturbances, tuberculosis and so on .

HY-N2925

β-Amyrone β-Amyron	Triterpenes Structural Classification Caprifoliaceae Source classification Plants Sambucus adnata Wall. ex DC.	Fungal COX PPAR
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity .

HY-N5077

Sinapine 2 Publications Verification	Alkaloids Structural Classification Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Cruciferae Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE) P-glycoprotein
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-N0450

Sinapine thiocyanate 2 Publications Verification	Alkaloids Structural Classification Monophenols Classification of Application Fields Other Alkaloids Cruciferae Source classification Phenols Plants Disease Research Fields Cancer	P-glycoprotein Cholinesterase (ChE)
Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-N5077B

Sinapine hydroxide	Alkaloids Monophenols other families Classification of Application Fields Neurological Disease Source classification Phenols Plants Disease Research Fields Inflammation/Immunology	Cholinesterase (ChE) P-glycoprotein
Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-156399

KR-27425	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited *acetylcholinesterase(AChE)* .

HY-N0342

Scopoletin 2 Publications Verification Gelseminic acid; Chrysatropic acid	Structural Classification Classification of Application Fields Source classification Coumarins Plants Monophenols Leguminosae Rubiaceae Phenols Phenylpropanoids Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Hedyotis diffusa Willd.	Cholinesterase (ChE) Apoptosis
Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-76299

Galanthamine Maximum Cited Publications 14 Publications Verification Galantamine	Alkaloids other families Source classification Plants	Cholinesterase (ChE) Apoptosis
Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

HY-N2219

Picfeltarraegenin X	Triterpenes Structural Classification Scrophularia ningpoensis Hemsl. Terpenoids Source classification Scrophulariaceae Plants	Cholinesterase (ChE)
Picfeltarraenin X, a triterpenoid isolated, is an *AChE* inhibitor .

HY-N0804A

Isonaringin	Citrus × aurantium Linnaeus Flavonoids Flavonones Source classification Rutaceae Phenols Polyphenols Plants	Cholinesterase (ChE)
Isonaringin shows anti-Alzheimer’s activity by inhibiting *AChE* .

HY-N2898

Artanin	Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Coumarins Phenylpropanoids Plants	Cholinesterase (ChE)
Artanin is a coumarin, has biological activities related to Alzheimer’s disease. Artanin exerts function including *AChE* inhibitory and AChE- and self-induced amyloid beta (Aβ) aggregation inhibitory activities, with IC₅₀s of 51 μM, 98 μM, and 124 μM, respectively .

HY-N0810

Timosaponin AIII	Structural Classification Liliaceae Neurological Disease Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids Cancer	Cholinesterase (ChE)
Timosaponin AIII could inhibit acetylcholinesterase *(AChE)* activity, with an IC₅₀ of 35.4 μM.

HY-N8755

Chikusetsusaponin Ib	Triterpenes other families Terpenoids Source classification Plants	Cholinesterase (ChE)
Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent *AChE* inhibitor .

HY-N10425

2-Hydroxyalbrassitriol	Microorganisms Terpenoids Sesquiterpenes Source classification	Cholinesterase (ChE)
2-Hydroxyalbrassitriol (Compound 6) is an *AChE* inhibitor with an IC₅₀ of 35.97 μM .

HY-N7263

Galanthamine N-Oxide	Alkaloids Structural Classification other families Source classification Plants	Cholinesterase (ChE)
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

HY-113626

(-)-Cyclopenin (-)-Cyclopenine	Alkaloids Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Cholinesterase (ChE)
(-)-Cyclopenin ((-)-Cyclopenine) is the enantiomer of Cyclopenin. Cyclopenin is a selective acetylcholinesterase (AChE) inhibitor with the IC₅₀ of 2.04 μM .

HY-N2034

Dehydrodicentrine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Stephania epigaea Lo Plants Menispermaceae	Cholinesterase (ChE)
Dehydrodicentrine is an alkaloid inhibitor of acetylcholinesterase (AChE) (IC₅₀=2.98 μM). Dehydrodicentrine .

HY-N4261

Dehydronuciferine	Alkaloids other families Classification of Application Fields Source classification Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields	Cholinesterase (ChE)
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 25 μg/mL .

HY-N7612

N-Desmethyl Galanthamine N-Norgalanthamine	Alkaloids other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Cholinesterase (ChE)
N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM .

HY-N0342R

Scopoletin (Standard)	Structural Classification Monophenols Leguminosae Source classification Rubiaceae Coumarins Phenols Phenylpropanoids Plants Glycyrrhiza uralensis Fisch. Hedyotis diffusa Willd.	Cholinesterase (ChE) Apoptosis
Scopoletin (Standard) is the analytical standard of Scopoletin. This product is intended for research and analytical applications. Scopoletin is an inhibitor of acetylcholinesterase (AChE).

HY-W004287

Methyl tridecanoate	Natural Products other families Source classification Plants	Amyloid-β Cholinesterase (ChE)
Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE) .

HY-123887

Manumycin B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Cholinesterase (ChE)
Manumycin B is an antibiobic, and exhibits antitumor activity. Manumycin B is an inhibitor for acetylcholinesterase (AChE) with an IC₅₀ of 15 mM .

HY-N0286

Isoimperatorin 2 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Disease Research Fields Cancer	Cholinesterase (ChE) Bacterial
Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC₅₀ of 74.6 μM.

HY-N5120

Dihydrowithaferin A 2,3-Dihydrowithaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Cholinesterase (ChE)
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE) .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (1) CHO (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72811

	*Acetylcholinesterase/ACHE* Protein, Mouse (HEK293, His)** Acetylcholinesterase; AChE	Mouse	HEK293
	Acetylcholinesterase (ACHE) proteins exhibit multiple functions, including acetylcholinesterase activity and protein self-association. It regulates acetylcholine processing, receptor signaling and recycling. Acetylcholinesterase/ACHE Protein, Mouse (HEK293, His) is the recombinant mouse-derived Acetylcholinesterase/ACHE protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P79277

	*Acetylcholinesterase/ACHE* Protein, Human (CHO, His)** acetylcholinesterase (Yt blood group); Acetylcholinesterase; AChE; apoptosis-related acetylcholinesterase; ARAChE; EC 3.1.1; EC 3.1.1.7; N-AChE; Yt blood group; YT	Human	CHO
	Acetylcholinesterase (ACHE) protein is pivotal in neurotransmission, rapidly hydrolyzing acetylcholine in the synaptic cleft to terminate signal transduction at the neuromuscular junction. Beyond neurotransmitter regulation, ACHE is implicated in neuronal apoptosis, indicating a broader role in cellular processes associated with programmed cell death. Acetylcholinesterase/ACHE Protein, Human (CHO, His) is the recombinant human-derived Acetylcholinesterase/ACHE protein, expressed by CHO , with C-6*His labeled tag. The total length of Acetylcholinesterase/ACHE Protein, Human (CHO, His) is 583 a.a..

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Cat. No.	Product Name	Chemical Structure

HY-14566S

Donepezil-d7 hydrochloride
Donepezil-d₇ (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

HY-14566S1

Donepezil-d5
Donepezil-d₅ is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

HY-B0034S1

Donepezil-d4 hydrochloride
Donepezil-d₄ (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].

HY-B0034S

Donepezil-d5 hydrochloride
Donepezil-d₅ (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].

HY-132409S

Monocrotophos-d6
Monocrotophos-d₆ is the deuterium labeled Monocrotophos. Monocrotophos. Monocrotophos is an organophosphate insecticide with broad application in crops. Monocrotophos inhibits the activity of the acetylcholine esterase (AChE) enzyme and affects the neurotransmission between neurons[1].

HY-B0841S

Acephate-d3
Acephate-d₃ is the deuterium labeled Acephate. Acephate is an anticholinesterase insecticide that produces cholinotoxicity. Acephate displays weak inhibition of rat AChE but potently inhibits cockroach AChE.

HY-W004287S

Methyl tridecanoate-d25
Methyl tridecanoate-d₂₅ is the deuterium labeled Methyl tridecanoate. Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE)[1].

HY-76299S1

Galanthamine-O-methyl-d3
Galanthamine-O-methyl-d₃ is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

HY-N2511S

Trimyristin--d15
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively[1].

HY-114899S

Azamethiphos-d6
Azamethiphos-d₆ is deuterated labeled Azamethiphos. Azamethiphos is an organophosphate insecticide and a neurotoxic agent, causing acetylcholinesterase *(AChE)* inhibition .

HY-76299S

Galanthamine-d6
Galanthamine-d₆ (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

HY-B0830S

Isoprocarb-d3
Isoprocarb-d₃ is deuterium labeled Isoprocarb. Isoprocarb is carbamate insecticide that widely used to control rice paddy lice and leafhopper. Isoprocarb is also an AChE inhibitor[1].

HY-B0732S

Itopride-d6 hydrochloride
Itopride-d₆ (hydrochloride) is deuterium labeled Itopride (hydrochloride). Itopride hydrochloride (HSR803), a gastroprokinetic Benzamide (HY-Z0283) derivative, is an inhibitor of acetylcholinesterase (AChE) and dopamine D2 receptor[1][2].

HY-I1111S2

Fmoc-L-Val-OH-13C5,15N
Fmoc-L-Val-OH- ¹³C₅, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Pirimicarb. Pirimicarb is a fast-acting selective carbamate insecticide on a wide range of crops including cereals, sugar beet, potatoes, fruits and vegetables. Pirimicarb is an AChE inhibitor and an

HY-135761S

Penconazole-d7
Penconazole-d₇ is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].

HY-136610S

Chlorpyrifos-oxon-d10
Chlorpyrifos-oxon-d₁₀ is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function[1][2][3][4].

HY-B1881S

Pirimiphos-methyl-d6
Pirimiphos-methyl-d₆ is the deuterium labeled Pirimiphos-methyl. Pirimiphos-methyl is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains[1][2][3].

HY-N6608S

Physostigmine-d3

Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].

HY-B0815S

Chlorpyrifos-d10

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-17368S1

(Rac)-Rivastigmine-d6

(Rac)-Rivastigmine-d₆ is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2].

HY-A0009S

Galanthamine-d3 hydrobromide

Galanthamine-d₃ (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD)[1][2][3].

HY-17368S2

Rivastigmine-d3 hydrochloride

Rivastigmine-d₃ hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-17387S1

(-)-Huperzine A-d4 hydrochloride

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

Cat. No.	Product Name		Classification

HY-10399A

Ladostigil hydrochloride TV-3326 hydrochloride		Alkynes
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and *AChE*, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10400

Ladostigil hemitartrate TV-3326 hemitartrate		Alkynes
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and *AChE*, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease . Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159151

AChE/Aβ-IN-6		Azide
BACE1-IN-15 (compound 4j) is a potent inhibitor of BACE1 (β-secretase) that can inhibited the copper ion induced Aβ toxicity, with the EC₅₀ of 0.68 μM .

HY-121072

ASS234		Alkynes
ASS234 is a potent monoamino oxidase (MAO) inhibitor with IC₅₀s of 5.2 nM and 43 nM for MAO-A and MAO-B, respectively. ASS234 also inhibits *AChE* and BuChE with IC₅₀s of 350 nM and 460 nM, respectively .

HY-10399

Ladostigil TV-3326		Alkynes
Ladostigil (TV-3326) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and *AChE*, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS00156

ACHE Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ACHE Human Pre-designed siRNA Set A contains three designed siRNAs for ACHE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00157

Ache Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Ache Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ache gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00158

ACHE Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ACHE Rat Pre-designed siRNA Set A contains three designed siRNAs for ACHE gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-148412A

Monarsen sodium EN101 sodium; ODN 7040 sodium; BL 7040 sodium		Antisense Oligonucleotides
Monarsen sodium is a synthetic 20-base antisense oligodeoxynucleotide directed against the human *AChE* gene. Monarsen sodium is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).

HY-148412

Monarsen EN101; ODN 7040; BL 7040		Antisense Oligonucleotides
Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human *AChE* gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).

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