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Results for "

microtubule

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MARK (5) MASTL (3) Microtubule/Tubulin (278) ADC Antibody (3) ADC Cytotoxin (39) ADC Linker (1) Akt (1) AMPK (5) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (8) Antibody-Drug Conjugates (ADCs) (13) Apoptosis (122) ATP Synthase (1) Aurora Kinase (1) Autophagy (20) Bacterial (6) Bcr-Abl (2) Beta-secretase (1) Biochemical Assay Reagents (3) Caspase (5) Cholinesterase (ChE) (2) COX (5) CRISPR/Cas9 (1) Cytochrome P450 (1) Drug Intermediate (3) Drug Metabolite (1) Drug-Linker Conjugates for ADC (17) Dynamin (1) EGFR (4) Endogenous Metabolite (14) ERK (1) Estrogen Receptor/ERR (2) Ferroptosis (2) FGFR (1) Filovirus (1) Fluorescent Dye (2) Fungal (11) Glutaminase (1) Guanylate Cyclase (1) HDAC (4) Hedgehog (2) Herbicide (4) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (5) HIV (2) HIV Protease (1) HPV (1) HSV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (15) JAK (1) JNK (1) Kinesin (13) MDM-2/p53 (2) Mitochondrial Metabolism (1) mTOR (1) nAChR (2) Nectin-4 (3) NEKs (1) NOD-like Receptor (NLR) (4) Opioid Receptor (4) p38 MAPK (3) Parasite (14) PARP (3) Phosphodiesterase (PDE) (1) Phospholipase (2) Polo-like Kinase (PLK) (1) Potassium Channel (1) Pyruvate Kinase (1) Ras (1) Reactive Oxygen Species (7) SphK (1) Src (1) STAT (3) Tau Protein (3) TGF-beta/Smad (1) TGF-β Receptor (1) Topoisomerase (3) Wnt (1)
By Research Areas:	Cancer (352) Cardiovascular Disease (4) Endocrinology (2) Infection (32) Inflammation/Immunology (22) Neurological Disease (24)
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Targets Recommended: Microtubule/Tubulin MARK MASTL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-159891

Microtubule destabilizing agent-2	Microtubule/Tubulin Apoptosis Caspase	Cancer
Microtubule destabilizing agent-2 (Compound 21) is an orally active and selective antitumor compound targeting *microtubule* protein. Microtubule destabilizing agent-2 destabilizes *microtubule* proteins and inhibits microtubule polymers. Microtubule destabilizing agent-2 arrests the G0/G1 phase in human tumor cells. Microtubule destabilizing agent-2 induces Apoptosis by activating the cascade pathway of caspases. Microtubule destabilizing agent-2 has anti-inflammatory activity, as inhibiting TNF-α and IL-6 in vitro. Microtubule destabilizing agent-2 reduces tumors growth in xenograft mice .

HY-155647

Microtubule stabilizing agent-1	Microtubule/Tubulin	Cancer
Microtubule stabilizing agent-1 (compound 3l) is a Paclitaxel derivative that efficiently promotes tubulin polymerization. Microtubule stabilizing agent-1 shows antitumor efficacy .

HY-139981

Microtubule destabilizing agent-1	Microtubule/Tubulin	Cancer
Microtubule destabilizing agent-1 (Compound 12b) acts as a microtubule destabilizing agent (MDA) based on hydroxamic acid, could serve as a potential MDA for further investigation. Microtubule destabilizing agent-1 shows favorable metabolism stability, high bioavailability, and potent antitumor activity .

HY-145828

Microtubule inhibitor 2	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 2 is a potent and selective, orally active *microtubule* inhibitor. Microtubule inhibitor 2 triggers cell death through ferroptosis . Microtubule inhibitor 2 shows antitumor activity .

HY-161075

Microtubule inhibitor 8	Microtubule/Tubulin Ferroptosis	Cancer
Microtubule inhibitor 8 (MP-HJ-1b) is a potent inhibitor of *microtubule. Microtubule* inhibitor 8 triggers cell death through ferroptosis. Microtubule inhibitor 8 has anti-tumor effect .

HY-147727

Microtubule inhibitor 6	Microtubule/Tubulin	Cancer
Microtubule inhibitor 6 (compound 17o) is a potent *microtubule* inhibitor. Microtubule inhibitor 6 shows cytotoxicity with IC₅₀s of 14.0, 6.6, 7.0 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 6 efficiently inhibits microtubule polymerization .

HY-147726

Microtubule inhibitor 5	Microtubule/Tubulin	Cancer
Microtubule inhibitor 5 (compound 17f) is a potent *microtubule* inhibitor. Microtubule inhibitor 5 shows cytotoxicity with an IC₅₀ value of 154.5 nM for NCI-H460 cells. Microtubule inhibitor 5 shows good cell permeability .

HY-161734

Microtubule inhibitor 11	Microtubule/Tubulin	Cancer
Microtubule inhibitor 11 (compound 33) is a microtubule inhibitor with a mechanism of action similar to colchicine (HY-N0282). Microtubule inhibitor 11 can be used in cancer-related research .

HY-147725

Microtubule inhibitor 4	Microtubule/Tubulin	Cancer
Microtubule inhibitor 4 (compound 2) is a potent *microtubule* inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC₅₀s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization .

HY-114313

Microtubule inhibitor 1	Microtubule/Tubulin	Cancer
Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity, with an IC₅₀ value of 9-16 nM in cancer cells .

HY-168714

Microtubule inhibitor 12	Microtubule/Tubulin Apoptosis	Cancer
Microtubule inhibitor 12 (Compound 2k) is an inhibitor for microtubule polymerization with an IC₅₀ of 22.23 μM. Microtubule inhibitor 12 arrests the cell cycle of B16-F10 at G2/M phase, induces apoptosis in B16-F10, and inhibits cell migration. Microtubule inhibitor 12 inhibits the proliferation of cancer cells B16-f10, A549, HepG2 and MCF-7, with IC₅₀s of 0.098, 0.135, 0.109, and 0.259 μM, respectively. Microtubule inhibitor 12 exhibits antitumor efficacy in mouse model .

HY-161153

Microtubule inhibitor 9	Apoptosis	Cancer
Microtubule inhibitor 9 (Compound O-7) is a 2-Aryl-1H-benzo [d] imidazole derivative with in vitro anticancer activity. Microtubule inhibitor 9 can induce cell cycle arrest at the G2/M phase and early apoptosis. Microtubule inhibitor 9 inhibits cancer cell migration by inhibiting wound healing and colony formation .

HY-P0181

Microtubule-associated protein tau (26-44)	Tau Protein	Neurological Disease
Microtubule-associated protein tau (26-44) is a synthetic peptide chain with an amine group attached to glutamine and an carboxyl group attached to lysine.

HY-147724

Microtubule inhibitor 3	Microtubule/Tubulin	Cancer
Compounds 17O (ic₅₀= 14.0 nm, NCI-H460) and 17p (ic₅₀= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

HY-147728

Microtubule inhibitor 7	Microtubule/Tubulin	Cancer
Compounds 17O (ic₅₀= 14.0 nm, NCI-H460) and 17p (ic₅₀= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.

HY-161145

*EGFR/microtubule-IN-1*	EGFR Apoptosis Microtubule/Tubulin	Cancer
EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC₅₀ for inhibiting EGFR is 10.66 nM. EGFR/microtubule-IN-1 can reduce the phosphorylation levels of EGFR, AKT and ERK, hinder tubulin polymerization, and induce apoptosis .

HY-131873

Dynapyrazole-A	Dynamin	Infection
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity .

HY-121908

FCPT	ATP Synthase	Cancer
FCPT, an ATP competitive inhibitor, induces a tight-binding of kinesin-5 onto microtubules and induced loss of microtubules selectively at the poles of Xenopus extract spindles without altering microtubule dynamics .

HY-13442

Eribulin 2 Publications Verification B1939; E7389; ER-086526	Microtubule/Tubulin Apoptosis ADC Cytotoxin	Cancer
Eribulin (E7389) is a *microtubule* targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

HY-13442A

Eribulin mesylate 2 Publications Verification B1939 mesylate; E7389 mesylate; ER-086526 mesylate	Microtubule/Tubulin Apoptosis	Cancer
Eribulin (E7389) mesylate is a *microtubule* targeting agent that is used for the research of metastatic breast cancer. Eribulin mesylate inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

HY-117841

T900607	Microtubule/Tubulin	Cancer
T900607 is an anti-tumor agent and targets microtubule polymerization .

HY-106399A

Acodazole hydrochloride	Microtubule/Tubulin	Cancer
Acodazole hydrochloride is an anticancer agent that exerts its anticancer activity by inhibiting microtubule polymerization .

HY-119169

Tubulozole	Microtubule/Tubulin	Cancer
Tubulozole is an orally active synthetic *microtubule* inhibitor. Tubulozole can be used for the research of tumor .

HY-13656

Isofludelone KOS-1803	Microtubule/Tubulin	Cancer
Isofludelone (KOS-1803) is a potential microtubule stabilizer for the treatment of solid tumors. Isofludelone has antitumor activity .

HY-14934

Rosabulin STA 5312	Microtubule/Tubulin	Cancer
Rosabulin (STA 5312) is a potent and orally active *microtubule* inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity .

HY-146692

IQTub4P	Microtubule/Tubulin	Cancer
IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC₅₀ of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo .

HY-171165

JC168	Microtubule/Tubulin	Cancer
JC168 is a phenyl analog of peloruside and serves as a *microtubule* inhibitor, demonstrating antiproliferative and anticancer activities. JC168 promotes tubulin polymerization, thereby interfering with microtubule dynamics, and can be utilized in research related to microtubule-associated disorders .

HY-138819

IMB5046	Apoptosis	Cancer
IMB5046 is a *microtubule* inhibitor that induces apoptosis by blocking the G2/M phase of the cell cycle. IMB5046 has anti-tumor activity .

HY-138056

7-Acetyl paclitaxel	Microtubule/Tubulin	Others
7-Acetyl paclitaxel is a microtubule depolymerization inhibitor which inhibits calcium-induced microtubule depolymerization. 7-Acetyl paclitaxel reduces the growth of J774.2 macrophages (IC₅₀ ~ 60 nM) and increases the levels of nitric oxide (NO) and TNF in isolated mouse peritoneal macrophages .

HY-126899

TPI-287	Microtubule/Tubulin	Cancer
TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain .

HY-128870

Mal-PEG2-VCP-Eribulin	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin (HY-13442). Eribulin is a mechanistically unique microtubule inhibitor and Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates .

HY-163737

ST-401	Microtubule/Tubulin	Cancer
ST-401, a microtubule-targeting agent (MTA), is a brain-penetrant microtubule (MT) assembly inhibitor. ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 shows a potent antitumor activity .

HY-W014240

Chlorpropham	Herbicide	Others
Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .

HY-121085

CID-663143	Microtubule/Tubulin	Cancer
CID-663143 targets microtubule-associated proteins, not tubulin itself, to inhibit the polymerization process within cells. CID-663143 inhibits cancer cell growth (IC₅₀: <100 nM for HT-1080, BJeLR, MCF10A cells) .

HY-144584

AGL-0182-30	Biochemical Assay Reagents	Others
AGL-0182-30 is a proprietary microtubule disrupting agent . AGL-0182-30 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-B0018

Docetaxal 2 Publications Verification 10-Acetyl docetaxel; PNU-101383	ADC Cytotoxin	Cancer
Docetaxal (10-Acetyl docetaxel) is an analog of Docetaxel (HY-B0011), with anticancer activity. Docetaxel is a microtubule disassembly inhibitor, with antimitotic activity .

HY-155956

GM-90257	Microtubule/Tubulin Apoptosis	Cancer
GM-90257 is a microtubule acetylation inhibitor that binds directly to α-tubulin. GM-90257 prevents the recruitment of α-tubulin acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes the apoptosis of MDA-MB-231 cells with weaker effects on MCF-10A or MCF-7 cells, which have a relatively low level of microtubule acetylation .

HY-D2341

6FC-GABA-Taxol	Fluorescent Dye	Cancer
6FC-GABA-Taxol is a fluorescent probe with cell permeability, which is formed by connecting 6FC to the anticancer drug Taxol (HY-B0015) via γ-aminobutyric acid (GABA). 6FC-GABA-Taxol can bind to microtubules in living cells and image them through confocal microscopy. Additionally, 6FC-GABA-Taxol enables the quantification of microtubule binding using flow cytometry without the addition of efflux inhibitors .

HY-120921

Zoxamide RH-7281	Fungal	Infection
Zoxamide (RH-7281) is an oomycete fungicide. Zoxamide arrests nuclear division in Phytophthora capsici germlings and destroyed the microtubule cytoskeleton .

HY-147092

Oryzalin	Microtubule/Tubulin	Others
Oryzalin is a dinitroaniline herbicide, binding to plant tubulin and inhibits microtubule (MT) polymerization in vitro. Oryzalin depolymerizes MTs and prevented the polymerization of new MTs at all stages of the mitotic cycle .

HY-100504

S-methyl DM1	Microtubule/Tubulin ADC Cytotoxin	Cancer
S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a K_d of 0.93 μM and inhibts *microtubule* polymerization. S-methyl DM1 potently suppresses *microtubule* dynamic instability and has anticancer effects .

HY-W014240R

Chlorpropham (Standard)	Herbicide	Others
Chlorpropham (Standard) is the analytical standard of Chlorpropham. This product is intended for research and analytical applications. Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .

HY-P4808

PHF6	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .

HY-147317

Epothilone E	Microtubule/Tubulin	Cancer
Epothilone E is a related compound of epothilone, which inhibits microtubule protein function and blocks cell division, and has anti-tumor activity .

HY-P4808A

PHF6 TFA	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein .

HY-147092R

Oryzalin (Standard)	Microtubule/Tubulin	Others
Oryzalin (Standard) is the analytical standard of Oryzalin. This product is intended for research and analytical applications. Oryzalin is a dinitroaniline herbicide, binding to plant tubulin and inhibits microtubule (MT) polymerization in vitro. Oryzalin depolymerizes MTs and prevented the polymerization of new MTs at all stages of the mitotic cycle .

HY-133222

STX140	Estrogen Receptor/ERR Microtubule/Tubulin Apoptosis	Cancer
STX140 is an orally active *microtubule* disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities .

HY-120921R

Zoxamide (Standard)	Fungal	Infection
Zoxamide (Standard) is the analytical standard of Zoxamide. This product is intended for research and analytical applications. Zoxamide (RH-7281) is an oomycete fungicide. Zoxamide arrests nuclear division in Phytophthora capsici germlings and destroyed the microtubule cytoskeleton .

HY-113722

DAT1	Microtubule/Tubulin	Cancer
DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization .

HY-N1171

Taxinine B Taxinin B	Microtubule/Tubulin	Cancer
Taxinine B is a taxoid that can be isolated from Japanese Yew Taxus Cuspid. Taxinine B inhibits CaCl₂-induced depolymerization of *microtubule*. Taxinine B is useful for overcoming multidrug resistance in tumor cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7526

Naphthazarin 1 Publications Verification DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone	Quinones Structural Classification other families Source classification Phenols Polyphenols Plants Naphthalene Quinones	Apoptosis
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects .

HY-16569

Colchicine 30+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a *microtubule* disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-13716

Noscapine 1 Publications Verification (S,R)-Noscapine	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Quinoline Alkaloids Papaver somniferum Linn. Plants Inflammation/Immunology Disease Research Fields Papaveraceae	Opioid Receptor Apoptosis
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-N0227

7-epi-Taxol 3 Publications Verification 7-epi-Paclitaxel	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Microtubule/Tubulin
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting *microtubule* bundle formation and against microtubule depolymerization.

HY-N0488

Vincristine sulfate 50+ Cited Publications Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Anti-aging Source classification Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Cancer	Microtubule/Tubulin Apoptosis
Vincristine sulfate is an antitumor vinca alkaloid which inhibits *microtubule* formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to *microtubule* with a K_i of 85 nM.

HY-N1171

Taxinine B Taxinin B	Structural Classification Natural Products Taxus cuspidata Siebold & Zucc. Taxaceae Source classification Plants	Microtubule/Tubulin
Taxinine B is a taxoid that can be isolated from Japanese Yew Taxus Cuspid. Taxinine B inhibits CaCl₂-induced depolymerization of *microtubule*. Taxinine B is useful for overcoming multidrug resistance in tumor cells .

HY-N11600

β-Apopicropodophyllin	Structural Classification Labiatae Varthemia iphionoides Boiss Source classification Lignans Phenylpropanoids Plants	Apoptosis
β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer .

HY-N10558

PM050489	Structural Classification Natural Products Animals Source classification	Microtubule/Tubulin
PM050489 is an effective polyketone inhibitor of *Microtubule/Tubulin* that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC₅₀ value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research .

HY-13716R

Noscapine (Standard)	Structural Classification Alkaloids Source classification Quinoline Alkaloids Papaver somniferum Linn. Plants Papaveraceae	Opioid Receptor Apoptosis
Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [4] .

HY-16569R

Colchicine (Standard)	Structural Classification Natural Products other families Source classification Plants	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-N11067

Taccalonolide E	Structural Classification Source classification Plants Tacca chantrieri Andre Taccaceae Steroids	Apoptosis
Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.

HY-15552

Podofilox 3 Publications Verification Podophyllotoxin	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-N0488R

Vincristine (sulfate) (Standard)	Apocynaceae Alkaloids Structural Classification Source classification Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don	Microtubule/Tubulin Apoptosis
Vincristine (sulfate) (Standard) is the analytical standard of Vincristine (sulfate). This product is intended for research and analytical applications. Vincristine sulfate is an antitumor vinca alkaloid which inhibits *microtubule* formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to *microtubule* with a K_i of 85 nM.

HY-N2346

Tubulysin E	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7049

Tubulysin F	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7052

Tubulysin I	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7053

Tubulysin M	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7050

Tubulysin G	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2348

Tubulysin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2347

Tubulysin C	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7051

Tubulysin H	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-17435

4'-Demethylepipodophyllotoxin 2 Publications Verification 4'-O-demethylepipodophyllotoxin; 4'-DMEP	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

HY-N0227R

7-epi-Taxol (Standard)	Structural Classification Terpenoids Taxaceae Source classification Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-N2146

Combretastatin A4 4 Publications Verification CRC 87-09	Structural Classification Monophenols other families Stilbenes Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Microtubule/Tubulin
Combretastatin A4 is a *microtubule*-targeting agent that binds β-tubulin with K_d of 0.4 μM.

HY-13674

Maytansine NSC 153858	Alkaloids Other Alkaloids Source classification Celastraceae Maytenus hookeri Loes. Plants Disease Research Fields Cancer	Microtubule/Tubulin
Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations .

HY-113074R

Glycolithocholic acid 3-sulfate (Standard)	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	HIV Endogenous Metabolite
Propyzamide (Standard) is the analytical standard of Propyzamide. This product is intended for research and analytical applications. Propyzamide is a anti-microtubule herbicide .

HY-77574

7-xylosyltaxol 7-Xylosylpaclitaxel; Taxol-7-xyloside	Classification of Application Fields Terpenoids Source classification Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin
7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

HY-15739

Ansamitocin P-3 5+ Cited Publications Antibiotic C 15003P3; Maytansinol isobutyrate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Microtubule/Tubulin ADC Cytotoxin Bacterial Antibiotic
Ansamitocin P-3 (Antibiotic C 15003P3) is a *microtubule* inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

HY-15552R

Podofilox (Standard)	Structural Classification Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae	Microtubule/Tubulin
Podofilox (Standard) is the analytical standard of Podofilox. This product is intended for research and analytical applications. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-20584

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Classification of Application Fields Terpenoids Source classification Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin ADC Cytotoxin
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

HY-N1450

Aristolochic acid C	Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Phospholipase
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A₂ (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

HY-N3225

Myricanol	Myrica ceriferaL. Structural Classification Source classification Phenols Polyphenols Plants Myricaceae	Microtubule/Tubulin
Myricanol is a constituent of Myrica cerifera (bayberry/southern wax myrtle) root bark. Myricanol can lower the levels of the microtubule-associated protein tau (MAPT) .

HY-13780

Vinblastine sulfate 10+ Cited Publications Vincaleukoblastine sulfate salt	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Cancer	Microtubule/Tubulin nAChR Autophagy
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-17435R

4'-Demethylepipodophyllotoxin (Standard)	Structural Classification Monophenols Source classification Lignans Phenols Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae	Microtubule/Tubulin
4'-Demethylepipodophyllotoxin (Standard) is the analytical standard of 4'-Demethylepipodophyllotoxin. This product is intended for research and analytical applications. 4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

HY-N6997

Ceratamine A	Alkaloids Structural Classification Animals Classification of Application Fields Other Alkaloids Marine natural products Source classification Sponge Disease Research Fields Cancer	Microtubule/Tubulin
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

HY-126556

Cytochalasin J	Structural Classification Natural Products Microorganisms Source classification	Microtubule/Tubulin
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

HY-127166

Colchiceine O10-Demethylcolchicine	Colchicaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Colchicum autumnale L.	Microtubule/Tubulin
Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-119407

Terpendole E	Structural Classification Microorganisms Iridoids Terpenoids Source classification	Kinesin
Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase .

HY-N7289

Taxuspine B	Structural Classification Taxus cuspidata Siebold & Zucc. Ketones, Aldehydes, Acids Source classification Taxaceae Plants	Others
Taxuspine B is a natural product, that can be isolated from Japanese yew Taxus. Taxuspine B exhibits appreciable taxol-like activity to reduce CaCl₂-induced depolymerixation of microtubules among the taxoids .

HY-N1450R

Aristolochic acid C (Standard)	Structural Classification Monophenols other families Source classification Phenols Plants	Phospholipase
Aristolochic acid C (Standard) is the analytical standard of Aristolochic acid C. This product is intended for research and analytical applications. Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

HY-13780R

Vinblastine (sulfate) (Standard)	Apocynaceae Alkaloids Structural Classification Source classification Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don	Microtubule/Tubulin Autophagy nAChR
Vinblastine (sulfate) (Standard) is the analytical standard of Vinblastine (sulfate). This product is intended for research and analytical applications. Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-N0282

Demecolcine 3 Publications Verification	Alkaloids Structural Classification other families Classification of Application Fields Other Alkaloids Source classification Plants Inflammation/Immunology Disease Research Fields	Microtubule/Tubulin Apoptosis
Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-N1098R

Velutin (Standard)	Structural Classification Flavonoids Microorganisms other families Flavones Source classification Phenols Polyphenols Plants	HIF/HIF Prolyl-Hydroxylase
Colchiceine (Standard) is the analytical standard of Colchiceine. This product is intended for research and analytical applications. Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-127166R

Colchiceine (Standard)	Colchicaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Colchicum autumnale L.	Microtubule/Tubulin
Colchiceine (Standard) is the analytical standard of Colchiceine. This product is intended for research and analytical applications. Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-N3028

Taccalonolide B	Structural Classification Classification of Application Fields Source classification Schizocapsa plantaginea Hance Plants Disease Research Fields Taccaceae Steroids Cancer	Microtubule/Tubulin
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-B0011

Docetaxel Maximum Cited Publications 109 Publications Verification RP-56976	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis Endogenous Metabolite
Docetaxel (RP-56976) is a *microtubule depolymerization* inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-N10958

Wikstrol A	Structural Classification Flavonols Flavonoids Microorganisms Source classification	Fungal HIV Microtubule/Tubulin
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM .

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Microtubule/Tubulin Beta-secretase Apoptosis
Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (?-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus wallichiana Zucc. Cancer	Microtubule/Tubulin
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

Cat. No.	Product Name	Chemical Structure

HY-B0413S

Fenbendazole-d3

3 Publications Verification

Fenbendazole-d₃ is a deuterium labeled Fenbendazole. Fenbendazole-d₃ is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1][2][3][4].

HY-N0488S1

Vincristine-d3-ester sulfate
Vincristine-d₃-ester (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1].

HY-15579AS

MMAF-d8 hydrochloride 1 Publications Verification
MMAF-d₈ (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.

HY-15581S

MMAD-d8
MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

HY-15583S

Auristatin F-d8
Auristatin F-d₈ is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent *microtubule* inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

HY-W014240S1

Chlorpropham-d7
Chlorpropham-d₇ is the deuterium labeled Chlorpropham[1]. Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules[2][3].

HY-N0488S2

Vincristine-d6 sulfate
Vincristine-d₆ (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.

HY-N0488S

Vincristine-d3 sulfate
Vincristine-d₃ (sulfate)is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1][2].

HY-16569S

Colchicine-d6
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

HY-16569S1

Colchicine-d3
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

HY-13442AS

Eribulin-d3 mesylate
Eribulin-d₃ (mesylate) is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer[1][2].

HY-15552S

Podofilox-d6
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II[1][2].

HY-115364S

Parbendazole-d3
Parbendazole-d₃ is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-12522S

PF-06380101-d8 2 Publications Verification
PF-06380101-d₈ is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue[1].

HY-136610S

Chlorpyrifos-oxon-d10
Chlorpyrifos-oxon-d₁₀ is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function[1][2][3][4].

HY-107116S

MAP4343-d4
MAP4343-d₄ is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2][3].

HY-B0294S

Flubendazole-d3
Flubendazole-d₃ is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3].

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC50 value of 0.2 μM[1]. Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis[1][3].

HY-13716S

Noscapine-13C,d3

Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-78131S3

Ibuprofen-13C6

Ibuprofen- ¹³C₆ ((±)-Ibuprofen- ¹³C₆) is a ¹³C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

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