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Results for "

anticancer effects

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (3) 5-HT Receptor (2) ADC Cytotoxin (3) Adrenergic Receptor (1) Akt (11) Aldehyde Dehydrogenase (ALDH) (2) Aminopeptidase (2) AMPK (1) Amylases (2) Androgen Receptor (4) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (14) Antibody-Drug Conjugates (ADCs) (1) Antifolate (1) Apoptosis (150) Arrestin (2) Aryl Hydrocarbon Receptor (2) ATM/ATR (1) Aurora Kinase (5) Autophagy (44) Bacterial (43) Bcl-2 Family (8) BCL6 (1) Bcr-Abl (1) Biochemical Assay Reagents (1) Bradykinin Receptor (1) Btk (4) c-Fms (1) c-Kit (3) c-Met/HGFR (2) c-Myc (1) Calcium Channel (15) Casein Kinase (3) Caspase (7) Cathepsin (1) CD20 (1) CDK (4) CGRP Receptor (1) Checkpoint Kinase (Chk) (2) Cholinesterase (ChE) (4) Complement System (1) COX (10) CXCR (4) Cytochrome P450 (6) Deubiquitinase (3) Dihydrofolate reductase (DHFR) (1) Dihydroorotate Dehydrogenase (1) Discoidin Domain Receptor (1) DNA/RNA Synthesis (14) Dopamine Receptor (3) Drug Metabolite (5) DYRK (1) E1/E2/E3 Enzyme (2) EGFR (9) Endogenous Metabolite (27) Endothelin Receptor (1) Enterovirus (1) Epigenetic Reader Domain (4) ERK (11) Estrogen Receptor/ERR (2) FAK (3) Farnesyl Transferase (1) Ferroptosis (4) FLT3 (2) Fungal (20) Glucosidase (1) GLUT (2) Glutaminase (1) Glyoxalase (GLO) (1) GSK-3 (2) Haspin Kinase (1) HBV (6) HDAC (8) Hedgehog (4) HIF/HIF Prolyl-Hydroxylase (5) Histone Acetyltransferase (1) Histone Demethylase (2) Histone Methyltransferase (2) HIV (4) HSP (1) HSV (2) IAP (2) Insulin Receptor (1) Integrin (1) Interleukin Related (6) Isotope-Labeled Compounds (13) JAK (1) JNK (5) Keap1-Nrf2 (3) Lipoxygenase (2) MALT1 (3) MAP4K (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (8) MEK (1) Microtubule/Tubulin (8) Mitochondrial Metabolism (2) Mitophagy (2) MMP (5) Molecular Glues (1) mTOR (3) Na+/H+ Exchanger (NHE) (3) NAMPT (2) Necroptosis (1) NF-κB (19) NO Synthase (9) Notch (1) Nucleoside Antimetabolite/Analog (13) Oct3/4 (1) Opioid Receptor (7) Oxidative Phosphorylation (2) P-glycoprotein (5) p38 MAPK (12) p97 (1) Parasite (26) PARP (10) PDGFR (1) Phosphatase (6) Phosphodiesterase (PDE) (1) PI3K (8) Pim (3) PINK1/Parkin (2) PKC (4) PKD (3) Polo-like Kinase (PLK) (1) Potassium Channel (4) PPAR (7) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (1) PROTACs (4) Protease Activated Receptor (PAR) (2) PTEN (2) Raf (1) RAR/RXR (1) Ras (8) Reactive Oxygen Species (23) RET (3) SARS-CoV (7) Sirtuin (5) Sodium Channel (11) Src (3) STAT (7) Survivin (1) TAM Receptor (1) TGF-beta/Smad (9) Tie (2) TNF Receptor (8) Toll-like Receptor (TLR) (1) Topoisomerase (7) TRP Channel (5) Tyrosinase (3) ULK (1) VEGFR (10) Virus Protease (6) VSV (1) Wee1 (4) Wnt (4) α-synuclein (2) β-catenin (1)
By Research Areas:	Cancer (411) Cardiovascular Disease (32) Endocrinology (2) Infection (74) Inflammation/Immunology (111) Metabolic Disease (41) Neurological Disease (61)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Nucleosides and their Analogs (11) Cholesterol (1)

430

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

182

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13670

Lurtotecan GI147211; OSI-211	Topoisomerase	Cancer
Lurtotecan (GI147211; OSI-211), a semisynthetic Camptothecin analog, is a topoisomerase I inhibitor. Lurtotecan has anticancer effects .

HY-145664

Myt1-IN-1	Wee1	Cancer
Myt1-IN-1 is a potent Myt1 inhibitor with an IC₅₀ of <10 nM. Myt1-IN-1 has anticancer effects (WO2021195782A1; compound 132) .

HY-N3369

Longistylin C Longistyline C	Others	Cancer
Longistylin C (Longistyline C) is a natural stilbene with anticancer effects .

HY-N10797

(-)-Haplomyrfolin	Others	Cancer
(-)-Haplomyrfolin is a natural lignan with anticancer effects .

HY-160219S

BTK-IN-33	Btk	Cancer
BTK-IN-33 is a Btk inhibitor with anticancer effects (WO2023174300A1; compound I) .

HY-N6579

Arvenin I	Others	Cancer
Arvenin I is a natural cucurbitacin glucoside with moderate anticancer effects .

HY-115709

4,6-O-Benzylidene-D-glucose	Others	Cancer
4,6-O-Benzylidene-D-glucose is a benzaldehyde derivative with anticancer effects .

HY-13670A

Lurtotecan dihydrochloride GI147211 dihydrochloride; OSI-211 dihydrochloride	Topoisomerase	Cancer
Lurtotecan dihydrochloride (GI147211), a semisynthetic Camptothecin analog, is a topoisomerase I inhibitor. Lurtotecan dihydrochloride has anticancer effects .

HY-162114

PARP1-IN-18	PARP	Cancer
PARP1-IN-18 (compound 25) is a potent PARP1 inhibitor with an IC₅₀ value of 2.7 nM. PARP1-IN-18 has anticancer effects .

HY-145665

Myt1-IN-2	Wee1	Cancer
Myt1-IN-2 is a potent Myt1 inhibitor with an IC₅₀ of <10 nM. Myt1-IN-2 has anticancer effects (WO2021195782A1; compound 28) .

HY-150255

IMP2-IN-3	Others	Cancer
IMP2-IN-3 is a potent IMP2 inhibitor. IMP2-IN-3 shows anticancer effects .

HY-N3722

O-Demethylmurrayanine	Others	Cancer
O-Demethylmurrayanine is a natural phenol with anticancer effects. O-Demethylmurrayanine exhibits strong cytotoxicity against MCF-7 and SMMC-7721 with IC₅₀ values in the range 4.42-7.59 μg/mL .

HY-123308

VPC13163	Androgen Receptor	Cancer
VPC13163 is a potent androgen receptor (AR) BF3 inhibitor with an IC₅₀ of 0.31 µM. VPC13163 has anticancer effects .

HY-121362

Evernic Acid	Bacterial Endogenous Metabolite	Inflammation/Immunology
Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects .

HY-N3627

Coronalolide methyl este NSC 680073	Others	Cancer
Coronalolide methyl ester (NSC 680073) is a natural triterpene with anticancer effects. Coronalolide methyl ester shows moderately cytotoxic to KATO-3, SW-620, and Hep-G2 cells., with IC₅₀ values of 8.64 µg/mL, 6.19 µg/mL, and 6.8 µg/mL, respectively .

HY-148974

PLK1-IN-5	Polo-like Kinase (PLK)	Cancer
PLK1-IN-5 is a potent PLK1 inhibitor with an IC50 of < 500 nM. PLK1-IN-5 shows anticancer effects (WO2008113711A1; compound I-4) .

HY-162245

PROTAC SMARCA2 degrader-3	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-3 is a PROTAC degrader of the SWI/SNF ATPase subunits, SMARCA2. PROTAC SMARCA2 degrader-3 has anticancer effects (WO2023244764A1; Compound 153) .

HY-158175

EGFR T790M/L858R-IN-4	EGFR	Cancer
EGFR T790M/L858R-IN-4 (Example 14) is a potent EGFR ^T790M/L858R inhibitor with anticancer effects .

HY-122782

Lucidal Lucialdehyde C	Glucosidase	Metabolic Disease Cancer
Lucidal (Lucialdehyde C) is a natural lanostante-type triterpene aldehyde that shows inhibitory effects against α-glucosidase (Glucosidase) with an IC₅₀ of 0.635 mM. Lucidal has anticancer and antidiabetic effects .

HY-N7535

Chlorovaltrate K	Others	Cancer
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

HY-N3626

Coronalolide	Others	Cancer
Coronalolide is a natural triterpene with anticancer effects. Coronalolide exhibits a broad cytotoxic activity for human breast (BT474), gastric (KATO-3), lung (CHAGO), colon (SW-620), and liver (Hep-G2) cancer cell lines, with IC₅₀ values of 6.59 µg/mL, 5.85 µg/mL, 5.42 µg/mL, 4.98 µg/mL, and 6.41 µg/mL, respectively .

HY-157330

P-gp inhibitor 16	P-glycoprotein Apoptosis	Cancer
P-gp inhibitor 16 (compound 14) is a p-glycoprotein inhibitor. P-gp inhibitor 16 significantly increases Doxorubicin-induced apoptosis and shows anticancer effects .

HY-P99538

Ublituximab LFB-R603; TG-1101; TGTX-1101	CD20	Cancer
Ublituximab (LFB-R603; TG-1101; TGTX-1101) is a next-generation, type 1 chimeric monoclonal antibody targeting a unique epitope on the CD20 antigen. Ublituximab has anticancer effects .

HY-157149

DS21150768	MAP4K	Cancer
DS21150768 is a potent, orally active HPK1 inhibitor. DS21150768 shows potent activity to enhance T-cell function. DS21150768 has anticancer effects .

HY-160447

FAK/aurora kinase-IN-1	Aurora Kinase FAK	Cancer
FAK/aurora kinase-IN-1 is a FAK and aurora kinase inhibitor with IC₅₀ values of 6.61 nM and 0.91 nM, respectively. FAK/aurora kinase-IN-1 shows anticancer effects (WO2018019252A1; compound 11) .

HY-162307

Nrf2 degrader 1	PROTACs Keap1-Nrf2	Cancer
Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC₅₀ values of 100 nM and 40 nM, respectively .

HY-142922

BCR-ABL-IN-4	Bcr-Abl	Cancer
BCR-ABL-IN-4 is a BCR-ABL inhibitor with anticancer effects. BCR-ABL-IN-4 inhibits the cancer cell growth with IC₅₀ values of 0.67 nM and 16 nM for K562 cells and BCR-ABL T315I transfected Ba/F3 cells, respectively (WO2021143927A1; compound 11) .

HY-N10354

27-Methyl withaferin A	Apoptosis	Cancer
27-Methyl withaferin A (comppund 26) is an apoptosis inducer with anticancer effects. 27-Methyl withaferin A shows antiproliferative effects against HeLa, A-549 and MCF-7 human tumor cell lines with IC₅₀ values of 3.2 μM, 4.2 μM and 1.4 μM, respectively .

HY-153276

Androgen receptor-IN-5	Androgen Receptor	Cancer
Androgen receptor-IN-5 is an androgen receptor inhibitor with potent anticancer effects. Androgen receptor-IN-5 also inhibits the production of IL-17A, IL- 17F and INF-γ (WO2023281097A1,Example 1/1) .

HY-145817A

lunresertib 1 Publications Verification RP-6306	Wee1	Cancer
lunresertib (RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC₅₀ of 14 nM. lunresertib shows a high degree of selectivity over other kinases in cellular binding assays. lunresertib shows anticancer effects .

HY-P99473

Bersanlimab BI-505	Integrin	Cancer
Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects .

HY-113722

DAT1	Microtubule/Tubulin	Cancer
DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization .

HY-153413

Kras4B G12D-IN-1	Ras	Cancer
Kras4B G12D-IN-1 is a Kras4B G12D inhibitor with anticancer effects. Kras4B G12D-IN-1 decreases Kras protein expression in mouse embryonic fibroblasts (MEF) expressing Kras4B G12D (WO2016179558A1, Comp 994566) .

HY-158407

Anticancer agent 220	Apoptosis	Cancer
Anticancer agent 220 is a chromanone derivative with anticancer effects. Anticancer agent 220 shows highly potent activity in the colon cancer cell lines. Anticancer agent 220 induces apoptosis and cell cycle arrest in cells .

HY-N7229

Rabdosin B	DNA/RNA Synthesis	Cancer
Rabdosin B is an ent-kaurene diterpenoid with anticancer effects. Rabdosin B induces DNA damage in cells, and inhibits lettuce root hair development of seedlings .

HY-141604

Glembatumumab vedotin CDX-011; CR011-vcMMAE	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Glembatumumab vedotin (CDX-011) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects .

HY-124808

IMM-01	Ras Apoptosis	Cancer
IMM-01 is a mammalian Diaphanous (mDia)-related formins agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC₅₀ of 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects .

HY-P99330

Vanucizumab Anti-Human VEGFA Recombinant Antibody; RO5520985	VEGFR Tie	Cancer
Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and angiopoietin-2 (Ang-2) from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects .

HY-145303

DX2-201	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC₅₀ of 312 nM. DX2-201 has anticancer effects .

HY-149602

Glutaminase C-IN-2	Glutaminase Reactive Oxygen Species	Cancer
Glutaminase C-IN-2 (compound 11) is glutaminase C (GAC) allosteric inhibitor with an IC₅₀ of 10.64 nM. Glutaminase C-IN-2 regulates the cellular metabolite, thereby increasing reactive oxygen species (ROS) by blocking glutamine metabolism. Glutaminase C-IN-2 has anticancer effects .

HY-151915

ATR-IN-20	ATM/ATR mTOR	Cancer
ATR-IN-20 is a potent ATR (ATM/ATR) inhibitor with an IC₅₀ of 3 nM. ATR-IN-20 possess an inhibitory effect on mTOR (IC₅₀ of 18 nM) while displaying good selectivity against PI3Kα (100 nM), ATM (100 nM), and DNA-PK (662 nM). ATR-IN-20 exhibits excellent pharmacokinetic profile (F = 30%), and has anticancer effects .

HY-149099

RET-IN-22	RET	Cancer
RET-IN-22 (compound 17b) is a potent, selective and orally active RET inhibitor with an IC₅₀ of 20.9 nM and 18.3 nM for wild-type RET and RET-V804M, respectively. RET-IN-22 shows highly selective profile to most kinases, especially to EGFR and VEGFR2. RET-IN-22 has anticancer effects .

HY-15698A

CRT0066101 dihydrochloride 2 Publications Verification	PKD Pim Apoptosis	Inflammation/Immunology Cancer
CRT0066101 dihydrochloride is a potent and orally active PKD inhibitor with IC₅₀ values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively . CRT0066101 dihydrochloride is also a potent PIM2 inhibitor with an IC₅₀ of ~135.7 nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects .

HY-15698

CRT0066101 2 Publications Verification	PKD Pim Apoptosis	Inflammation/Immunology Cancer
CRT0066101 is a potent and orally active PKD inhibitor with IC₅₀ values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively . CRT0066101 is also a potent PIM2 inhibitor with an IC₅₀ of ~135.7 nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects .

HY-145432

PI3K-IN-28	PI3K	Cancer
PI3K-IN-28 (Compound 6c) is a potent inhibitor of PI3K. PI3K-IN-28 displays the most potent activity with lower toxic effects on MCF-10a. PI3K-IN-28 displays half-maximal inhibitory concentration (IC₅₀, μM) values of 5.8, 2.3, and 7.9. PI3K-IN-28 is the most potent one with a selectivity index (SI) of 39 and is considered as a latent lead for further optimization of anticancer agents .

HY-N3831

Epimedokoreanin B	Bacterial Apoptosis	Infection Inflammation/Immunology Cancer
Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and *Porphyromonas gingivalis* growth and biofilm formation .

HY-12354

SB-3CT 15+ Cited Publications	MMP	Cancer
SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with K_i values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity .

HY-123849

SN32976	PI3K mTOR	Cancer
SN32976 is a potent and selective class I PI3K and mTOR inhibitor with IC₅₀s of 15.1 nM, 461 nM, 110 nM, 134 nM and 194 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR, respectively. SN32976 shows high selectivity among other 442 kinases. SN32976 shows anticancer effects .

HY-15698B

CRT0066101 trihydrochloride	PKD Pim Apoptosis	Inflammation/Immunology Cancer
CRT0066101 trihydrochloride is the trihydrochloride salt form of CRT0066101 (HY-15698). CRT0066101 trihydrochloride is an orally active PKD inhibitor with IC₅₀ values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively. CRT0066101 trihydrochloride is also an inhibitor for PIM2 with an IC₅₀ of ~135.7 nM. CRT0066101 trihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects .

HY-164489

KU004	EGFR Akt ERK Apoptosis	Cancer
KU004 is a potent dual EGFR/HER2 inhibitor with anticancer effects. KU004 inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR and downstream Akt and Erk pathways and induces cell Apoptosis mainly via the extrinsic pathway. KU004 is a quinazoline derivative .

Cat. No.	Product Name

HY-L107

Anti-Cancer Natural Product Library

1,706 compounds

With features of enormous scaffold diversity and structural complexity, natural products (NPs) are the main sources of lead compounds and new drugs and play a highly significant role in the drug discovery and development process, especially for cancer and infectious diseases. A large number of natural products have been proven to have potential anti-tumor effects, mainly from plants, animals, Marine organisms and microorganisms. At present, derived than 60% of anti-tumor drugs come from natural sources, and they are widely used in breast, prostate and colon cancers.

MCE offers a unique collection of 1,706 natural products with validated anti-cancer activity. MCE anti-cancer natural product library is a useful tool for anti-tumor drugs screening and other related research.

HY-L065

Traditional Chinese Medicine Active Compound Library

2,924 compounds

Chinese herbal therapy is an important part of Traditional Chinese Medicine (TCM). It has been used for centuries in China, where herbs are considered fundamental therapy for many acute and chronic conditions. Many studies indicated TCM exerted an overall regulatory effect via multi-component and multi-target network. Active components from Traditional Chinese Medicine possess many medicinal properties such as antioxidant, anti-cancer, and anti-bacterial effects, which makes it an important source of new drugs. Nearly 200 modern medicines have been developed either directly or indirectly from the plants used as medicines in China. For example, artemisinin, used in multidrug resistant malaria, was first isolated from the Chinese herb Artemisia annua L. Today, scientists continue to identify compounds in Chinese herbal remedies that may be useful in the development of new therapeutic agents applicable in Western medicine.

MCE designs a unique collection of 2,924 active compounds of Chinese Herbal Medicines. MCE Traditional Chinese Medicine Active Compound Library is a useful tool for discovery new drugs from TCM.

Cat. No.	Product Name	Type

HY-B0166GL

L-Ascorbic acid (GMP Like)

L-Ascorbate (GMP Like); Vitamin C (GMP Like)

Fluorescent Dye

L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

Cat. No.	Product Name	Type

HY-B0166GL

L-Ascorbic acid (GMP Like)

L-Ascorbate (GMP Like); Vitamin C (GMP Like)

Biochemical Assay Reagents

HY-NP131

Recombinant Humanized Type III Collagen (30-40kDa)	Native Proteins
Recombinant Humanized Type III Collagen 30-40kDa is a novel biomaterial that have anticancer effects. Recombinant Humanized Type III Collagen 30-40kDa activates discoidin domain receptor 1 (DDR1), and thus inhibits autophagy, proliferation, and migration of cancer cells, and induces apoptosis .

Cat. No.	Product Name	Target	Research Area

HY-134545

N-Arachidonoyl-L-alanine NALA	Peptides	Cancer
N-Arachidonoyl-L-alanine is an endocannabinoid analog with *anti-cancer* effects. N- Arachidonoyl-L-alanine kills HNSCC cells through 5-LO-mediated ROS productio .

HY-P1682A

Balixafortide TFA 1 Publications Verification POL6326 TFA	CXCR Arrestin	Cancer
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

HY-107146

PZ-128 P1pal-7	Protease Activated Receptor (PAR)	Cardiovascular Disease Cancer
PZ-128 (P1pal-7), a cell-penetrating lipopeptide pepducin, is a first-in-class, specific and reversible protease-activated receptor-1 (PAR1) antagonist. PZ-128 targets the cytoplasmic surface of PAR1 and interrupts signaling to internally-located G (PAR1-G) proteins. PZ-128 has antiplatelet, anti-metastatic, anti-angiogenic and anticancer effects .

HY-106178

PMX-53 4 Publications Verification 3D53	Complement System	Cardiovascular Disease Inflammation/Immunology Cancer
PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC₅₀ of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .

HY-131923

DAPM	Notch	Cancer
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells .

HY-P1682

Balixafortide POL6326	CXCR Arrestin	Cancer
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

Cat. No.	Product Name	Target	Research Area

HY-P99508

Tamgiblimab IBI939	Inhibitory Antibodies	Cancer
Tamgiblimab (IBI939) is a fully human monoclonal antibody targeting T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT). Tamgiblimab has anticancer effects .

HY-P99538

Ublituximab LFB-R603; TG-1101; TGTX-1101	CD20	Cancer
Ublituximab (LFB-R603; TG-1101; TGTX-1101) is a next-generation, type 1 chimeric monoclonal antibody targeting a unique epitope on the CD20 antigen. Ublituximab has anticancer effects .

HY-P99473

Bersanlimab BI-505	Integrin	Cancer
Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects .

HY-P99330

Vanucizumab Anti-Human VEGFA Recombinant Antibody; RO5520985	VEGFR Tie	Cancer
Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and angiopoietin-2 (Ang-2) from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects .

HY-P99324

Tomuzotuximab Anti-Human EGFR Recombinant Antibody	EGFR Apoptosis	Cancer
Tomuzotuximab (Anti-Human EGFR Recombinant Antibody) is a fully human glycoengineered IgG1 monoclonal antibody against EGFR. Tomuzotuximab has anticancer effects .

HY-P99476

ABP 215	VEGFR	Cancer
ABP 215 (Bevacizumab-awwb), a Bevacizumab (Bevacizumab (HY-P9906)) biosimilar, is a humanized IgG1 monoclonal antibody targeting VEGFA (VEGFR). ABP 215 has anticancer effects, and can be used metastatic colorectal cancer (mCRC) research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121362

Evernic Acid	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Inflammation/Immunology	Bacterial Endogenous Metabolite
Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects .

HY-P99508

Tamgiblimab IBI939	Classification of Application Fields Disease Research Fields Cancer	Others
Tamgiblimab (IBI939) is a fully human monoclonal antibody targeting T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT). Tamgiblimab has anticancer effects .

HY-P99538

Ublituximab LFB-R603; TG-1101; TGTX-1101	Classification of Application Fields Disease Research Fields Cancer	CD20
Ublituximab (LFB-R603; TG-1101; TGTX-1101) is a next-generation, type 1 chimeric monoclonal antibody targeting a unique epitope on the CD20 antigen. Ublituximab has anticancer effects .

HY-N3369

Longistylin C Longistyline C	Lonchocarpus violaceus Source classification Plants Fabaceae	Others
Longistylin C (Longistyline C) is a natural stilbene with anticancer effects .

HY-N10797

(-)-Haplomyrfolin	Structural Classification Thymelaeaceae Source classification Stellera chamaejasme Linn. Lignans Phenylpropanoids Plants	Others
(-)-Haplomyrfolin is a natural lignan with anticancer effects .

HY-N6579

Arvenin I	Terpenoids Scrophulariaceae Diterpenoids Lagotis yunnanensis W. W. Smith Plants	Others
Arvenin I is a natural cucurbitacin glucoside with moderate anticancer effects .

HY-N3722

O-Demethylmurrayanine	Structural Classification Monophenols Clausena lansium (Lour.) Skeels Source classification Rutaceae Phenols Plants	Others
O-Demethylmurrayanine is a natural phenol with anticancer effects. O-Demethylmurrayanine exhibits strong cytotoxicity against MCF-7 and SMMC-7721 with IC₅₀ values in the range 4.42-7.59 μg/mL .

HY-N3627

Coronalolide methyl este NSC 680073	Structural Classification Natural Products Source classification Rubiaceae Plants Gardenia jasminoides Ellis	Others
Coronalolide methyl ester (NSC 680073) is a natural triterpene with anticancer effects. Coronalolide methyl ester shows moderately cytotoxic to KATO-3, SW-620, and Hep-G2 cells., with IC₅₀ values of 8.64 µg/mL, 6.19 µg/mL, and 6.8 µg/mL, respectively .

HY-N7535

Chlorovaltrate K	Structural Classification Valeriana jatamansi Jones Iridoids Terpenoids Source classification Plants Valerianaceae	Others
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

HY-N3626

Coronalolide	Triterpenes Structural Classification Terpenoids Source classification Rubiaceae Gardenia sootepensis hutchins. Plants	Others
Coronalolide is a natural triterpene with anticancer effects. Coronalolide exhibits a broad cytotoxic activity for human breast (BT474), gastric (KATO-3), lung (CHAGO), colon (SW-620), and liver (Hep-G2) cancer cell lines, with IC₅₀ values of 6.59 µg/mL, 5.85 µg/mL, 5.42 µg/mL, 4.98 µg/mL, and 6.41 µg/mL, respectively .

HY-P99473

Bersanlimab BI-505	Classification of Application Fields Disease Research Fields Cancer	Integrin
Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects .

HY-N7229

Rabdosin B	Labiatae Ligularia duciformis (C. Winkl.) Hand.-Mazz. Plants	DNA/RNA Synthesis
Rabdosin B is an ent-kaurene diterpenoid with anticancer effects. Rabdosin B induces DNA damage in cells, and inhibits lettuce root hair development of seedlings .

HY-P99330

Vanucizumab Anti-Human VEGFA Recombinant Antibody; RO5520985	Classification of Application Fields Disease Research Fields Cancer	VEGFR Tie
Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and angiopoietin-2 (Ang-2) from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects .

HY-N3831

Epimedokoreanin B	Structural Classification Flavonoids Flavones Epimedium koreanum Nakai Source classification Plants Berberidaceae	Bacterial Apoptosis
Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and *Porphyromonas gingivalis* growth and biofilm formation .

HY-N8185

Loureiriol	Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	Others
Loureiriol is a homoisoflavonoid with weak anticancer effects .

HY-N0105

Rhein 5+ Cited Publications Rheic Acid; Rhubarb yellow; Monorhein	Structural Classification Classification of Application Fields Polygonaceae Source classification Plants Infection Quinones Rheum palmatum L. Anthraquinones Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Autophagy Reactive Oxygen Species Bacterial Apoptosis
Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects ^{[1] ^.}

HY-N9451

Ginger extract	Zingiber officinale Roscoe Natural Products Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Zingiberaceae	NF-κB
Ginger extract exhibits anti-cancer, anti-inflammatory and chemotherapeutic effects in vivo .

HY-16212

FR901464	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Others
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects .

HY-N0182

Fisetin 15+ Cited Publications	Flavonols Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Rosaceae Metabolic Disease Plants Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Fragaria × ananassa Duch. Cancer	Sirtuin PPAR TNF Receptor
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-N0423

Sophoricoside 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Sophora japonica (L.) Schott Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones	Others
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-N0182A

Fisetin quarterhydrate 15+ Cited Publications	Source classification Plants	Sirtuin PPAR TNF Receptor
Fisetin quarterhydrate is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-N2510

Myristicin Myristicine	Structural Classification Simple Phenylpropanols Source classification Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt.	5-HT Receptor EGFR ERK Apoptosis Bacterial
Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

HY-N0820

Catalpol 5+ Cited Publications Catalpinoside	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Infection Iridoids Terpenoids Scrophulariaceae Inflammation/Immunology Disease Research Fields Cancer	HBV
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0362

Columbianadin 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Plants Seriphidium transiliense Inflammation/Immunology Disease Research Fields	Apoptosis
Columbianadin, a natural coumarin from Heracleum hemsleyanum, is known to have various biological activities including anti-inflammatory and anti-cancer effects.

HY-N2510R

Myristicin (Standard)	Structural Classification Simple Phenylpropanols Source classification Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt.	5-HT Receptor EGFR ERK Apoptosis Bacterial
Myristicin (Standard) is the analytical standard of Myristicin. This product is intended for research and analytical applications. Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

HY-118620

Nortriptyline 2 Publications Verification Desmethylamitriptyline; Desitriptilina	Alkaloids Neurological Disease Classification of Application Fields Centaurea bracteata Scop. Other Alkaloids Labiatae Source classification Plants Disease Research Fields Cancer	Autophagy Drug Metabolite Apoptosis
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects . N

HY-N0013

Vitexin 5 Publications Verification	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Flavones Anti-aging Source classification Metabolic Disease Plants Flavonoids Leguminosae Phenols Polyphenols Trigonella foenum-graecum Linn. Disease Research Fields Cancer	Autophagy
Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N2039

20(R)-Ginsenoside Rg2	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Others
20(R)-Ginsenoside Rg2 shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities .

HY-119809

Violacein	Structural Classification Alkaloids Microorganisms Classification of Application Fields Sunscreen Source classification Cosmetic Research Disease Research Fields Indole Alkaloids Cancer	Apoptosis Endogenous Metabolite
Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer .

HY-N7044

Vitexin arginine	Cardiovascular Disease Flavonoids other families Classification of Application Fields Neurological Disease Flavones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Others
Vitexin arginine is a c-glycosylated flavone, and is found in various medicinal plants species such as Ficus deltoid and Spirodela polyrhiza. Vitexin arginine has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-B0134

Bestatin 5+ Cited Publications Ubenimex	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Aminopeptidase Bacterial Antibiotic
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-13748

Silybin A 5+ Cited Publications Silibinin A	Flavanonols Structural Classification Flavonoids Glycine soya Classification of Application Fields Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Disease Research Fields Cancer	Autophagy Reactive Oxygen Species
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

HY-W013573

S-Allyl-L-cysteine 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Anti-aging Source classification Metabolic Disease Allium sativum Linn. Plants Liliaceae Inflammation/Immunology Disease Research Fields Cancer	Apoptosis
S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.

HY-N12267A

Terrestribisamide (E)-N,N′-Diferuloylputrescine	Tribulus terrester Linn. Structural Classification Alkaloids Zygophyllaceae Source classification Plants Alkaloid Dimers	Bacterial Fungal
Terrestribisamide ((E)-N,N′-Diferuloylputrescine) can be isolated from dried fruits of Tribulus terrestris. Terrestribisamide has antibacterial, antifungal, antioxidant, anticancer effects .

HY-N5086

Picroside IV	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Monophenols Iridoids Terpenoids Phenols Scrophulariaceae Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	HBV
Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0820R

Catalpol (Standard)	Structural Classification Iridoids Terpenoids Source classification Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey	HBV
Catalpol (Standard) is the analytical standard of Catalpol. This product is intended for research and analytical applications. Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N4114

Picrocrocin	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Lridaceae Plants Crocus sativus L. Disease Research Fields Cancer	Apoptosis
Picrocrocin, an apocarotenoid found in Saffron. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells .

HY-10448

Capsaicin 35+ Cited Publications (E)-Capsaicin	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Solanaceae Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects .

HY-N0799

Protodioscin	Structural Classification Classification of Application Fields Leguminosae Source classification Plants Endogenous metabolite Trigonella foenum-graecum Linn. Disease Research Fields Steroids Cancer	Endogenous Metabolite
Protodioscin, a major steroidal saponin in Trigonella foenum-graecum Linn., has been shown to exhibit multiple biological actions, such as anti-hyperlipidemia, anti-cancer, sexual effects and cardiovascular properties.

HY-N0182R

Fisetin (Standard) 15+ Cited Publications	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Rosaceae Metabolic Disease Plants Flavonoids Phenols Inflammation/Immunology Disease Research Fields Cancer Fragaria × ananassa Duch.	Sirtuin PPAR TNF Receptor
Fisetin (Standard) is the analytical standard of Fisetin. This product is intended for research and analytical applications. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Structural Classification other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer	Interleukin Related Reactive Oxygen Species Topoisomerase
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-N7624

Methyl oleanonate 3-Oxoolean-12-en-28-oic acid methyl ester	Triterpenes Pistacia lentiscus var. Chia other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer Anacardiaceae	PPAR
Methyl oleanonate is a natural triterpene PPARγ agonist isolated from the species of Pistacia lentiscus var. Chia . Methyl oleanonate is a modified oleanolic acid derivative with anti-cancer effects .

HY-N0423R

Sophoricoside (Standard)	Structural Classification Flavonoids Leguminosae Source classification Sophora japonica (L.) Schott Phenols Polyphenols Plants Isoflavones	Others
Sophoricoside (Standard) is the analytical standard of Sophoricoside. This product is intended for research and analytical applications. Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects.

HY-N1410

Triacetylresveratrol	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Source classification Plants Disease Research Fields Cancer	STAT NF-κB
Triacetylresveratrol, an acetylated analog of Resveratrol. Triacetylresveratrol decreases the phosphorylation of STAT3 and NF-κB in a dose- and time- dependent manner in PANC-1 and BxPC-3 cells. Anticancer effects .

HY-W047478

3-Methylcarbazole NSC 10154	Alkaloids other families Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	Others
3-Methylcarbazole is an carbazole alkaloid compound with anticancer effects. 3-Methylcarbazole shows growth inhibitory activity (IC₅₀ of 25 μg/mL) on human fibrosarcoma HT-1080 cells .

HY-131503

13-Methyltetradecanoic acid 13-MTD; 13-Methylmyristic acid	Classification of Application Fields Leguminosae Glycine max (L.) merr Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Apoptosis
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-N0013R

Vitexin (Standard)	Structural Classification Flavonoids Flavones Leguminosae Source classification Phenols Polyphenols Plants Trigonella foenum-graecum Linn.	Autophagy
Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N2477

Taraxerol	Triterpenes Structural Classification Classification of Application Fields Terpenoids Astragalus oleifolius DC. Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	Apoptosis NF-κB
Taraxerol is isolated from Taraxacum mongolicum, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis .

HY-N0362R

Columbianadin (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Plants Seriphidium transiliense	Apoptosis
Columbianadin (Standard) is the analytical standard of Columbianadin. This product is intended for research and analytical applications. Columbianadin, a natural coumarin from Heracleum hemsleyanum, is known to have various biological activities including anti-inflammatory and anti-cancer effects.

Cat. No.	Product Name	Chemical Structure

HY-17514S

Itraconazole-d5

Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects[1][2][3].

HY-160219S

BTK-IN-33
BTK-IN-33 is a Btk inhibitor with anticancer effects (WO2023174300A1; compound I) .

HY-10448S1

Capsaicin-d3
Capsaicin-d₃ is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].

HY-N0182S3

Fisetin-d5
Fisetin-d5 is a deuterated labeled Fisetin . Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

HY-B0114S1

Oxcarbazepine-d4-1
Oxcarbazepine-d₄-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-B0114S

Oxcarbazepine-D4
Oxcarbazepine-d₄ (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

HY-13777S

Zoledronic acid-d5
Zoledronic acid-d₅ is deuterated labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects .

HY-10448S4

Capsaicin-d7
Capsaicin-d₇ is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects .

HY-131503S

13-Methyltetradecanoic acid-d6
13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-13653S

(+/-)-Epigallocatechin Gallate-13C3

(+/-)-Epigallocatechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects[1]. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.

HY-17412S1

Minocycline-d6 sulfate
Minocycline-d₆ sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally effective semi-synthetic tetracycline antibiotic and HIF-1α inhibitor that can penetrate the blood-brain barrier. Minocycline has bacteriostatic, anti-cancer, anti-inflammatory, neuroprotective properties and antidepressant effects.

HY-B0114S2

Oxcarbazepine-d8-1
Oxcarbazepine-d8-1 is a deuterium of Oxcarbazepine. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Oxcarbazepine-d8-1 has anti-cancer and anticonvulsant effects .

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3].

HY-14393S

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

HY-17514S2

Itraconazole-d9

Itraconazole-d₉ is the deuterium labeled Itraconazole[1]. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor[2][3][4][5].

HY-B0166S

L-Ascorbic acid-13C6

L-Ascorbic acid- ¹³C₆ is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

HY-B0166S1

L-Ascorbic acid-13C

L-Ascorbic acid- ¹³C is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

HY-13716S

Noscapine-13C,d3

Noscapine-13C,d3 is a deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-101193S

Zinc Protoporphyrin-d2,15N2

Zinc Protoporphyrin-d₂, ¹⁵N₂ is ¹⁵N and deuterated labeled Zinc Protoporphyrin (HY-101193). Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H₂O₂ . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .

HY-B0166S8

L-Ascorbic acid-13C6-1

L-Ascorbic acid- ¹³C₆-1 (L-Ascorbate-1; Vitamin C- ¹³C₆-1) is a ¹³C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

Cat. No.	Product Name		Classification

HY-126271

PYCR1-IN-1		Alkynes
PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC₅₀ of 8.8 µM. PYCR1-IN-1 has anticancer effects .

HY-151953

Antitubulin agent 1		Alkynes
Antitubulin agents-1 is an antitubulin agent that induces disruption of the microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation. Antitubulin agents-1 has anticancer effects . Antitubulin agent 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-152980

4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine		Nucleosides and their Analogs
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154046

4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine		Nucleosides and their Analogs
4,6-Diamino-1-(2-deoxy-beta-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-152990

Methyl 1,2,3,4-tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetate		Nucleosides and their Analogs
Methyl 1,2,3,4-tetrahydro-α-hydroxy-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidineacetate is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154122

6-Amino-4-methoxy-1-(2-deoxy-a-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine		Nucleosides and their Analogs
6-Amino-4-methoxy-1-(2-deoxy-a-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-152987

7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine		Nucleosides and their Analogs
7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-152986

4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine		Nucleosides and their Analogs
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154047

6-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine		Nucleosides and their Analogs
6-Amino-4-hydrozino-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154008

6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine		Nucleosides and their Analogs
6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154002

4-Amino-5-cyano-1-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine		Nucleosides and their Analogs
4-Amino-5-cyano-1-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-154005

4-Amino-6-bromo-5-cyano-1-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine		Nucleosides and their Analogs
4-Amino-6-bromo-5-cyano-1-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-152977

4-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine		Nucleosides and their Analogs
4-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects .

HY-113289

Brassicasterol		Cholesterol
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

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