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Results for "

E. coli

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (2) Acyltransferase (1) ADC Cytotoxin (2) Aldehyde Dehydrogenase (ALDH) (2) Amino Acid Derivatives (2) Aminoacyl-tRNA Synthetase (1) Antibiotic (66) Antifolate (2) Apoptosis (7) Autophagy (7) Bacterial (253) Beta-lactamase (2) Biochemical Assay Reagents (11) CD28 (2) COX (3) Dihydrofolate reductase (DHFR) (3) DNA/RNA Synthesis (12) Drug Derivative (1) Endogenous Metabolite (23) Fatty Acid Synthase (FASN) (1) Fluorescent Dye (9) Fungal (17) Gli (1) Glycosyltransferase (1) HIV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (1) Isotope-Labeled Compounds (4) MAPKAPK2 (MK2) (1) Mitochondrial Metabolism (1) MyD88 (1) NF-κB (1) Nucleoside Antimetabolite/Analog (2) Oxidative Phosphorylation (1) Parasite (1) Penicillin-binding protein (PBP) (1) Phosphodiesterase (PDE) (1) Phospholipase (1) Phosphorylase (1) Pyruvate Kinase (1) Reactive Oxygen Species (1) Renin (1) Smo (1) Toll-like Receptor (TLR) (8) Topoisomerase (10) β-glucuronidase (1)
By Research Areas:	Cancer (43) Cardiovascular Disease (1) Infection (263) Inflammation/Immunology (33) Metabolic Disease (13)
Click Chemistry:	Labeling and Fluorescence Imaging (2) Azide (1) Alkynes (2)
Oligonucleotides:	Nucleosides and their Analogs (1) Nucleoside Phosphoramidites (1) Polymers (1)

331

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

109

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155048

BDM91270	Bacterial	Infection
BDM91270 (compound 29) is an E. coli AcrAB-TolC efflux pump inhibitor with an EC₉₀ of 0.6 μM for wild-type E. coli AcrB. BDM91270 can be used in the study of Escherichia coli drug resistance .

HY-P2854

Alanine dehydrogenase, expressed in E. coli	Endogenous Metabolite	Metabolic Disease
Alanine dehydrogenase, expressed in E. coli is a microbial enzyme that catalyzes a reversible conversion of L-alanine to pyruvate .

HY-D1056

*Lipopolysaccharides, from E. coli* O55:B5** Maximum Cited Publications 221 Publications Verification LPS	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Lipopolysaccharides, from E. coli O55:B5 is an endotoxin extracted from E. coli O55:B5, consisting of an antigen-specific chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activates TLR-4 of immune cells. Lipopolysaccharides, from E. coli O55:B5 can induce the change of body temperature in rats with dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 caused a heterogeneous and dose-independent increase in body temperature in rats .

HY-D1056A2

*Lipopolysaccharides, from E. coli* O127:B8** LPS, from Escherichia coli (O127:B8)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from E. coli O127:B8 is a lipopolysaccharide endotoxin from E. coli O127:B8 and TLR-4 activator, Activates disease-associated molecular patterns (PAMPs) of the immune system and induces cell secretion of migratory bodies. Lipopolysaccharides, from E. coli O127:B8 consists of an antigen-specific O-chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O127:B8 can induce changes in body temperature in rats and is dose and serotype specific. High dose of Lipopolysaccharides, from E. coli O127:B8 can cause a double change of body temperature in rats, that is, hypothermia followed by fever. In addition, Lipopolysaccharides, from E. coli O127:B8 can induce inflammation and inhibit reproduction, and can significantly increase the mitotic activity of mollusks .

HY-157351

E.Coli Broth	Biochemical Assay Reagents	Others
E.Coli Broth is a selectively concentrated broth that can be used to isolate, detect or culture E. coli.

HY-NP025

E.coli Bacterial protein EPEC	Bacterial	Infection
E.coli Bacterial protein is a native protein that can be isolated from E.coli .

HY-NP020

E.coli DH-5 alpha Bacterial protein E.coli DH-5 alpha protein	Bacterial	Others
E.coli DH-5 alpha Bacterial protein is a purified native protein from E.coli DH-5 alpha bacterial .

HY-E70412

Galactose 1-dehydrogenase, E.coli	Endogenous Metabolite	Metabolic Disease
Galactose 1-dehydrogenase, E.coli is a dehydrogenase expressed in E. coli. Galactose 1-dehydrogenase, E.coli catalyzes the oxidation of L-arabinose and D-galactose using NADP ⁺/NAD ⁺ as cofactors. Galactose 1-dehydrogenase, E.coli can be used in diagnostic tests to determine total galactose content and can also serve as a biocatalyst for producing galacturonate .

HY-148197

Glutathionylspermidine	Endogenous Metabolite	Others
Glutathionylspermidine is a peptide and a metabolite of E. coli .

HY-156859A

NSC309401	Bacterial	Infection
NSC309401 is an inhibitor of E. coli DHFR (IC₅₀: 189 nM, K_D: 14.57 nM) .

HY-117065

MAC173979	Bacterial	Infection
MAC173979 is a inhibitor of PABA synthesis in E. coli. MAC173979 can be used for study of antibacterial drug development .

HY-133154

Carboxyaminoimidazole ribotide 1 Publications Verification CAIR; 4-Carboxy-AIR	Endogenous Metabolite	Infection
Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .

HY-161987

LpxH-IN-2	Bacterial	Infection
LpxH-IN-2 (compound 014) is a potent LpxH inhibitor. LpxH-IN-2 shows antibacterial activity for E. coli .

HY-D1056A5

*Lipopolysaccharides, from E. coli* K-235** LPS, from Escherichia coli (K-235)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides are lipopolysaccharide endotoxins and TLR-4 activators that activate pathogenicity-associated molecular patterns (PAMPs) of the immune system and induce cell secretion of migrasomes. Lipopolysaccharides can be extracted from the outer leaflet of the outer membrane of Gram-negative bacteria and are composed of an antigenic O-specific chain, a core oligosaccharide, and lipid A. Lipopolysaccharides (LPS), from E. coli K-235 is a kind of endotoxins derived from E. coli* K-235* .

HY-D1056A4

*Lipopolysaccharides, from E. coli* O128:B12** LPS, from Escherichia coli (O128:B12)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from E. coli O128:B12 is commonly used to stimulate the inflammatory pathway in an infection/inflammation induced preterm animal model. Specific Lipopolysaccharides from E. coli serotypes induce activation of different inflammatory pathways in the neonatal rat brain. Compared with other Escherichia coli, Lipopolysaccharides (O111:B4, O55:B5, O127:B8), Lipopolysaccharides, from E. coli O128:B12 has lower induction efficiency of inflammation. Cub survival rate was 100% after the treatment .

HY-147381

MetRS-IN-1	Bacterial	Others
MetRS-IN-1 (Compound 27) is an E. coli methionyl-tRNA synthetase (MetRS) inhibitor (IC₅₀=237 nM) .

HY-118211

EcDsbB-IN-9	Bacterial	Infection
EcDsbB-IN-9 (Compound 9) is a potent E. coli DsbB (EcDsbB) inhibitor with an IC₅₀ of 1.7 μM and a K_i of 46 nM .

HY-P10848

RJPXD33	Bacterial	Infection
RJPXD33 is the inhibitor for LpxD and LpxA with IC₅₀ of 3.5 μM and 19 μM. RJPXD33 RJPXD33 inhibits LpxD and LpxA in E. coli with K_d of 6 μM and 20 μM .

HY-136861

Antibacterial agent 192	Bacterial	Infection
Antibacterial agent 192 is an antibacterial agent that can disrupt iron homeostasis in E. coli .

HY-P2869B

β1-4 Galactosidase, E. coli	Others	Metabolic Disease
β1-4 Galactosidase, E. coli is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing β1-4 linked galactose residues from oligosaccharides .

HY-P2733

Glycerol-3-phosphate oxidase, E. coli GPO	Endogenous Metabolite	Metabolic Disease
Glycerol-3-phosphate oxidase, E. coli (GPO) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase is the skeleton of phospholipids in membrane lipids, and also a substrate in the respiratory chain. Glycerol-3-phosphate oxidase produces electrons through oxidation .

HY-D1056A1

*Lipopolysaccharides, from E. coli* O111:B4** 1 Publications Verification LPS, from Escherichia coli (O111:B4)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides are lipopolysaccharide endotoxins and TLR-4 activators that activate pathogenicity-associated molecular patterns (PAMPs) of the immune system and induce cell secretion of migrasomes. Lipopolysaccharides can be extracted from the outer leaflet of the outer membrane of Gram-negative bacteria and are composed of an antigenic O-specific chain, a core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O111:B4 is a kind of endotoxins derived from E. coli .

HY-114509

Anilazine	Bacterial	Infection Metabolic Disease
Anilazine is a fungicide and inhibit the growth of Rhizobium sp. and E. coli. Anilazine inhibits glucose oxidation and succinate oxidation and also inhibits in vitro succinic dehydrogenase activity .

HY-N7322

Swietemahalactone	Bacterial	Infection
Swietemahalactone is a natural compound isolated from Swietenia mahagoni. Swietemahalactone exhibits antibacterial activity aganist E. coli .

HY-139747

Antibacterial agent 32	Bacterial	Infection
Antibacterial agent 32 (example 43) is an antibacterial agent with MIC values of 1 mcg/mL, 2 mcg/mL, and 8 mcg/mL against E. coli strains NCTC 13351, M 50 and 7 MP, respectively (WO2013030733A1) .

HY-139767

Antibacterial agent 50	Bacterial	Infection
Antibacterial agent 50 (example 47) is an antibacterial agent with MIC values of 32 mcg/mL, 64 mcg/mL, and 128 mcg/mL against E. coli strains NCTC 13351, M 50 and 7 MP, respectively (WO2013030733A1) .

HY-139768

Antibacterial agent 51	Bacterial	Infection
Antibacterial agent 51 (example 45) is an antibacterial agent with MIC values of 4 mcg/mL, 8 mcg/mL, and 8 mcg/mL against E. coli strains NCTC 13351, M 50 and 7 MP, respectively (WO2013030733A1) .

HY-P10257

KR-12 (human)	Bacterial	Infection
KR-12 human is an active segment of LL-37, which exhibits antimicrobial activity against gram-negative bacteria. KR-12 human inhibits E. coli K-12 with MIC of 66 μM .

HY-W009912

H-Tyr(Me)-OH	Amino Acid Derivatives	Others
H-Tyr(Me)-OH is a synthetic amino acid, and can enter into protein in E. coli in response to an amber nonsense codon .

HY-D2277

Fluorescein-CM2	Fluorescent Dye	Others
Fluorescein-CM2 is a fluorogenic molecule that can be used to rapidly screen esterase cut sites for protein-protein interaction-dependent (PPI-dependent) esterase activity in E. coli .

HY-D1056A3

*Lipopolysaccharides, from E. coli* O26:B6** LPS, from Escherichia coli (O26:B6)	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from E. coli O26:B6 is a lipopolysaccharide endotoxin and TLR-4 activator that activates the disease-related molecular pattern (PAMP) of the immune system and induces cell secretion of migratory bodies. Lipopolysaccharides, from E. coli O26:B6 consists of an antigen-specific O-chain, some cells lack an O-antigen-side chain, and is recognized by the core-specific monoclonal antibody MAb J8-4C10 .

HY-E70284

Keratanase II,bacillus circulans,expressed in E.coli	Biochemical Assay Reagents	Others
Keratanase II,bacillus circulans,expressed in E.coli has transglycosylation activity. Keratanase II,bacillus circulans,expressed in E.coli efficiently catalyzes the transglycosylation of α(2→3)-sialylated 6,6′-di-sulfo-LacNAc with two kinds of glycosyl acceptors, 6-sulfo-Lewis X and 6,6'-di-sulfo-LacNAc derivatives, providing Sialyl sulfo-hexasaccharide and Sialyl sulfo-pentasaccharide .

HY-117250

EcDsbB-IN-10	Others	Infection
EcDsbB-IN-10 (compound 12) is an inhibitor of EcDsbB (E. coli DsbB) enzyme, with a K_i of 0.8 nM and an IC₅₀ of 18.85 nM .

HY-114509R

Anilazine (Standard)	Bacterial	Infection Metabolic Disease
Anilazine (Standard) is the analytical standard of Anilazine. This product is intended for research and analytical applications. Anilazine is a fungicide and inhibit the growth of Rhizobium sp. and E. coli. Anilazine inhibits glucose oxidation and succinate oxidation and also inhibits in vitro succinic dehydrogenase activity .

HY-N3837

Epitaraxerol Isotaraxerol; 3α-Taraxerol	Bacterial	Infection
Epitaraxerol (compound 6) is a natural product isolated from the leaves of E. neriifolia. Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis* .*

HY-119749

Diazaborine	Bacterial	Infection
Diazaborine is an inhibitor for enoyl-acyl carrier protein (enoyl ACP) in an NAD+-dependent manner. Diazaborine exhibits antibacterial activity, MIC for E. coli and K. pneumoniae is 25 and 3.12 μg/mL .

HY-N8515C

UDP-3-O-acyl-GlcNAc disodium UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine disodium	Endogenous Metabolite	Infection Others
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) disodium is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .

HY-W109754

2',4'-Dihydroxylchalcone 2',4'-DHC	Bacterial	Infection
2',4'-Dihydroxychalcone, in combination with nalidixic acid (HY-B0398), exhibits synergistic effects against E. coli by reducing membrane permeability .

HY-130281

Ianthelliformisamine B diTFA	Bacterial	Inflammation/Immunology
Ianthelliformisamine B diTFA is a bromotyrosine-derived antibacterial agent. Ianthelliformisamine B diTFA is against E. coli and S. aureus strains with MICs of 14.5 μM and 144.7 μM .

HY-N9477

Betulinic aldehyde oxime Betulin-28-oxime	Drug Derivative Bacterial	Infection
Betulinic aldehyde oxime (Compound 31) is a betulin (HY-N0083) derivative that has antimicrobial properties against E. aerogenes, E. coli, E. faecalis, P. aeruginosa, S. aureus, and C. albicans. Betulinic aldehyde oxime displays cytotoxicity towards hepatocytes, with an IC₅₀ of 25 μM .

HY-139746

FPI-1602	Beta-lactamase Bacterial	Infection
FPI-1602 is a β-lactamase inhibitor. FPI-1602 displays marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp. .

HY-15935B

X-Gluc cyclohexanamine	Fluorescent Dye	Others
X-Gluc cyclohexanamine is a dye reagent for the detection of β-glucuronidase (GUS), an enzyme produced by E. coli. X-Gluc cyclohexanamine can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc cyclohexanamine is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-163708

Antibacterial agent	Antibiotic Bacterial	Infection
Antibacterial agent (compound 8b) is a potent antibacterial agent. Antibacterial agent shows robust antibacterial efect on E. coli and S. aureus with IC₅₀s of 64 and 32 µg/mL, respectively .

HY-15935C

X-Gluc sodium	Fluorescent Dye	Others
X-Gluc sodium is a dye reagent for the detection of β-glucuronidase (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-136638

ML328	Bacterial	Infection
ML328 is a selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC₅₀ values of 26 and 5.1 μM, respectively. ML328 is a gyrase inhibitor. ML328 strongly inhibits the growth of E. coli in the presence of phage. ML328 can be used for the research of bacterial infection .

HY-P5625

ROAD-1	Bacterial	Infection
ROAD-1 is an oral mucosal α-defensin of Rhesus Macaque. ROAD-1 is active against S. aureus, E. coli, and C. albicans .

HY-118827

Vedaprofen Quadrisol; CERM 10202; PM 150	COX	Inflammation/Immunology
Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM .

HY-N10607

2'-Hydroxy-3,4,4',6'-tetramethoxychalcone	Bacterial	Infection
2'-Hydroxy-3,4,4',6'-tetramethoxychalcone (Compound 5) has antibacterial activity, with a MIC value of 10 μg/mL for E. coli and S. epidermis. 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone can be isolated from Piper obliquum .

HY-P10389

Globomycin derivative G2A	Bacterial	Infection
Globomycin derivative G2A (Compound G2A) is an inhibitor for lipoprotein signal peptidase II (LspA), with an IC₅₀ of 604 nM. Globomycin derivative G2A inhibits E. coli, P. aeruginosa and A. baumannii, with MIC ranging from 12.5 to 32 μg/mL .

HY-P2869

β-Galactosidase, E. coli EC 3.2.1.23; GAL	Endogenous Metabolite	Others
β-Galactosidase (EC 3.2.1.23) is a glycoside hydrolase that hydrolyzes the β-glycosidic bonds formed between galactose and its organic moieties. In E.coli, the lacZ gene is the structural gene of β-galactosidase, which can be used as part of the induction system lac operon. β-Galactosidase can hydrolyze lactose to form glucose and galactose, and enter glycolysis; it can also catalyze the transgalactosylation of lactose into allolactose; allolactose can be cracked into monosaccharides .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D1056

*Lipopolysaccharides, from E. coli* O55:B5** Maximum Cited Publications 221 Publications Verification LPS	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Saccharides	Toll-like Receptor (TLR)
Lipopolysaccharides, from E. coli O55:B5 is an endotoxin extracted from E. coli O55:B5, consisting of an antigen-specific chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activates TLR-4 of immune cells. Lipopolysaccharides, from E. coli O55:B5 can induce the change of body temperature in rats with dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 caused a heterogeneous and dose-independent increase in body temperature in rats .

HY-133154

Carboxyaminoimidazole ribotide 1 Publications Verification CAIR; 4-Carboxy-AIR	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .

HY-N8515C

UDP-3-O-acyl-GlcNAc disodium UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine disodium	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) disodium is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .

HY-148197

Glutathionylspermidine	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glutathionylspermidine is a peptide and a metabolite of E. coli .

HY-N7322

Swietemahalactone	Structural Classification Natural Products Source classification Plants Swietenia mahagoni (L.) Jacq. Meliaceae	Bacterial
Swietemahalactone is a natural compound isolated from Swietenia mahagoni. Swietemahalactone exhibits antibacterial activity aganist E. coli .

HY-N3837

Epitaraxerol Isotaraxerol; 3α-Taraxerol	Triterpenes Structural Classification Excoecaria agallocha L. Terpenoids Source classification Euphorbiaceae Plants	Bacterial
Epitaraxerol (compound 6) is a natural product isolated from the leaves of E. neriifolia. Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis* .*

HY-130281

Ianthelliformisamine B diTFA	Structural Classification Natural Products Source classification Marine natural products Sponge	Bacterial
Ianthelliformisamine B diTFA is a bromotyrosine-derived antibacterial agent. Ianthelliformisamine B diTFA is against E. coli and S. aureus strains with MICs of 14.5 μM and 144.7 μM .

HY-N9477

Betulinic aldehyde oxime Betulin-28-oxime	Triterpenes Structural Classification Terpenoids Betula platyphylla Sukaczev Source classification Plants Betulaceae	Drug Derivative Bacterial
Betulinic aldehyde oxime (Compound 31) is a betulin (HY-N0083) derivative that has antimicrobial properties against E. aerogenes, E. coli, E. faecalis, P. aeruginosa, S. aureus, and C. albicans. Betulinic aldehyde oxime displays cytotoxicity towards hepatocytes, with an IC₅₀ of 25 μM .

HY-N10607

2'-Hydroxy-3,4,4',6'-tetramethoxychalcone	Source classification Piperaceae Plants Piper obliquum Ruiz & Pav.	Bacterial
2'-Hydroxy-3,4,4',6'-tetramethoxychalcone (Compound 5) has antibacterial activity, with a MIC value of 10 μg/mL for E. coli and S. epidermis. 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone can be isolated from Piper obliquum .

HY-N8060

Orotidine 5′-monophosphate Orotidine monophosphate; Orotidylic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of?uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase .

HY-N10087A

Angustifoline hydrochloride	Structural Classification Alkaloids Leguminosae Source classification Lupinus angustifolius L. Plants	Bacterial
Angustifoline hydrochloride, an alkaloid, can be isolated from Lupinus angustifolius L. alkaloid extract. Angustifoline hydrochloride exhibits antimicrobial activity. Angustifoline hydrochloride could have bacteriostatic effects against S. aureus, B. subtilis, E. coli, P. aeruginosa and B. thuringiensis .

HY-N12096

Galbinic acid α-Acetylsalazinic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Phenols Polyphenols	Bacterial
Galbinic acid (α-Acetylsalazinic acid), a lichen acid, shows antibacterial activities against the Gram-positive bacteria B. cereus, B. subtilis, and S. aureus (MICs=62.5, 62.5, 250 μg/ml, respectively). Galbinic acid inhibits the Gram-negative bacterium E. coli (MIC=125 μg/ml) .

HY-126170

Valanimycin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Antibiotic Bacterial
Valanimycin is an antibiotic, which inhibits Escherichia coli (BE1121) through interaction with DNA. Valanimycin exhibits cytotoxicity to mouse leukemia L1210, P388/S (doxorubicin (HY-15142A)-sensitive), and P388/ADR (doxorubicin-resistant), with IC₅₀ of 0.79, 2.65, and 1.44 μg/mL, respectively. Valanimycin exhibits antitumor efficacy against ehrlich ascites tumors or L1210 in mice .

HY-N12763

Sodium new houttuyfonate SNH	Structural Classification Natural Products Saururaceae Houttuynia cordata Thunb. Source classification Plants	Bacterial Renin
Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC₅₀ of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1 .

HY-Y0367

Maleic Acid 1 Publications Verification	Infection Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite Bacterial
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and *L. monocytogenes*.

HY-16943

Moiramide B	Microorganisms Source classification	Bacterial Acetyl-CoA Carboxylase
Moiramide B is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of 6 nM. Moiramide B has antibacterial activity .

HY-N8300

Rupesin E	Structural Classification Caprifoliaceae Iridoids Terpenoids Source classification Plants Patrinia rupestris (Pall.) Juss.	Bacterial
Rupesin E is a natural product that can be isolated from Patrinia rupestris. Rupesin E has significant antibacterial activity against Escherichia coli .

HY-N2594

Isoforsythiaside	Infection Structural Classification Oleaceae Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Disease Research Fields	Bacterial
Isoforsythiaside is an antioxidant and antibacterial phenylethanoid glycoside with MICs of 40.83, 40.83, and 81.66 μg/mL for Escherichia coli(E. coli), Pseudomonas aeruginosa(PAO), and Staphylococcus aureus (SA), respectively .

HY-N12320

Majoranaquinone	Quinones Structural Classification Labiatae Source classification Plants Naphthalene Quinones Baccharis sarothroides A.Gray	Antibiotic
Majoranaquinone exhibits a high antibacterial effect against 4 Staphylococcus, 1 Moraxella, and 1 Enterococcus strains. Majoranaquinone shows substantial efflux pump inhibitory activity in Escherichia coliATCC 25922 strain. Majoranaquinone is found to be an effective biofilm formation inhibitor on E.coli, ATCC 25922 and E. coli K-12 AG100 bacteria .

HY-N3651

Curzerenone	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Curcuma phaeocaulis Valeton Plants Disease Research Fields Zingiberaceae	Bacterial
Curzerenone is one of constituents of leaf essential oil extracted from L. pulcherrima. Shows slight inhibitory effective against E. coli .

HY-113270

Actinine γ-Butyrobetaine; Deoxycarnitine	Structural Classification Natural Products Microorganisms Marine algae Source classification Marine natural products Endogenous metabolite	Endogenous Metabolite
Actinine (γ-Butyrobetaine) is an amino acid betaine aminobutyric acid zwitterion. Actinine acts as both a human metabolite and a metabolite of E. coli .

HY-165154

Cyclamidomycin Desdanine; Pyracrimycin A	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial Fungal Pyruvate Kinase Oxidative Phosphorylation
Cyclamidomycin (Desdanine) is an acrylamide antibiotic with antibacterial activity. Cyclamidomycin inhibits nucleoside diphosphate kinase and pyruvate kinase (in E. coli) and oxidative phosphorylation in rat liver mitochondria. Cyclamidomycin is active against S. aureus, M. flavus, S. lutea, B. subtilis, E. coli, S. flexneri, S. typhosa, P. vulgaris, and K. pneumoniae (MICs=3.12-25 mg/ml) .

HY-N5127

Nonacosane	Infection Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields	Bacterial
Nonacosane, isolated from Baphia massaiensis, exhibits weak activities against E. coli, B. subtilis, P. aeruginosa and S. aureus .

HY-N1312

Sinapaldehyde	Infection Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	Bacterial
Sinapaldehyde exhibits moderate antibacterial against Methicillin resistant S. aureus (MRSA) and E. coli with MIC values of 128 and 128 μg/mL .

HY-17591

Penicillin G potassium 10+ Cited Publications Benzylpenicillin potassium	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Disease Research Fields	Antibiotic Bacterial
Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas .

HY-A0248

Polymyxin B Sulfate 10+ Cited Publications	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Mammalian Cell Culture Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo .

HY-N11422

Mycaminosyltylonolide	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research	Antibiotic Bacterial
Mycaminosyltylonolide is a potent antibiotic. Mycaminosyltylonolide shows antibacterial activity. Mycaminosyltylonolide inhibits luciferase synthesis .

HY-17591R

Penicillin G potassium (Standard)	Structural Classification Plant Cell Culture Microorganisms Antibiotics Source classification Animal Husbandry Mammalian Cell Culture Antibacterial Disease Research Other Antibiotics	Antibiotic Bacterial
Penicillin G (potassium) (Standard) is the analytical standard of Penicillin G (potassium). This product is intended for research and analytical applications. Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas .

HY-154871

α-D-Glucosamine 1-phosphate	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
α-D-Glucosamine 1-phosphate is an E.coli metabolite. α-D-Glucosamine 1-phosphate is one of the precursors of peptidoglycan synthesis .

HY-N6738

Bafilomycin B1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Bacterial Fungal Antibiotic
Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K ⁺-dependent ATPase of E. coli .

HY-N8515B

UDP-3-O-acyl-GlcNAc diammonium UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine diammonium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
UDP-3-O-acyl-GlcNAc diammonium is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .

HY-N5127R

Nonacosane (Standard)	Structural Classification Natural Products other families Source classification Plants	Bacterial
Nonacosane (Standard) is the analytical standard of Nonacosane. This product is intended for research and analytical applications. Nonacosane, isolated from Baphia massaiensis, exhibits weak activities against E. coli, B. subtilis, P. aeruginosa and S. aureus .

HY-130778

N,N'-Diacetylchitobiose	Structural Classification Microorganisms Animals Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Endogenous Metabolite
N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli .

HY-113054

DL-Glyceraldehyde 3-phosphate	Infection Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Acyltransferase Bacterial Endogenous Metabolite
DL-Glyceraldehyde 3-phosphate is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. DL-Glyceraldehyde 3-phosphate is a potent inhibitor of the growth of E. coli. DL-Glyceraldehyde 3-phosphate is a competitive inhibitor of the acyltransferase .

HY-N10087

Angustifoline	Structural Classification Alkaloids Leguminosae Lupinus angustifolius L. Plants	Bacterial
Angustifoline, an alkaloid, can be isolated from Lupinus angustifolius L. alkaloid extract. Angustifoline exhibits antimicrobial activity. Angustifoline could have bacteriostatic effects against S. aureus, B. subtilis, E. coli, P. aeruginosa and B. thuringiensis .

HY-N1079

Vitexilactone	Structural Classification Terpenoids Verbenaceae Diterpenoids Plants Vitex negundo Linn.	Bacterial Apoptosis
Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer .

HY-141465

3-Hydroxybutyryl-CoA	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
3-Hydroxybutyryl-CoA is a metabolite which can be found in mouse or E.coli, et al. 3-Hydroxybutyryl-CoA has a 3-hydroxybutanoyl as the S-acyl component, and is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan .

HY-126634

Lyngbyatoxin B	Structural Classification Natural Products other families Source classification Plants Lyngbya majuscule	Others
Lyngbyatoxin B is a complex compound in a versatile biosynthetic pathway from the marine cyanobacterium Moorea producens. By heterologously expressing the lyngbyatoxin biosynthetic pathway in Escherichia coli, lyngbyatoxin A (25.6 mg/L) and its precursor indolactam-V (150 mg/L) were successfully produced. This approach confirmed the biosynthetic route of lyngbyatoxin and laid a chemical foundation for future pathway engineering. In addition, the successful production of lyngbyatoxin A in E. coli opens the possibility for heterologous expression and characterization of other cyanobacterial natural products.

HY-N8515

UDP-3-O-acyl-GlcNAc UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .

HY-W585865

UDP-3-O-acyl-GlcNAc Tris UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine Tris	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) Tris is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .

HY-N1654

2',3'-Dehydrosalannol	Infection Natural Products Classification of Application Fields Source classification Plants Azadirachta indica A. Juss. Disease Research Fields Meliaceae	Bacterial
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 µg/mL, respectively .

HY-B0117

Tigecycline 20+ Cited Publications GAR-936	Microorganisms Source classification	Bacterial Autophagy Antibiotic
Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL . MIC₅₀ and MIC₉₀ are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively .

HY-P5683

Maximin 45	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial
Maximin 45 is an antimicrobial peptide. Maximin 41 has antibacterial activity against S. aureus, E. coli, B. subtilis (MIC: 4.7, 9.4, 75 μg/mL). Maximin 45 has hemolytic activities against human and rabbit red cells .

HY-113245

3-Indolyl-β-D-glucuronide	Structural Classification Alkaloids Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite
3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in? patients' plasma act as a new indicator of renal failure .

HY-B0117R

Tigecycline (Standard) GAR-936 (Standard)	Microorganisms Source classification	Bacterial Autophagy Antibiotic
Tigecycline (Standard) is the analytical standard of Tigecycline. This product is intended for research and analytical applications. Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL . MIC₅₀ and MIC₉₀ are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively .

HY-N7307

Pachybasin	Infection Quinones Structural Classification Monophenols Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Disease Research Fields	Bacterial
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .

HY-Y0367R

Maleic Acid (Standard)	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite	Endogenous Metabolite Bacterial
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and *L. monocytogenes. IC₅₀* & Target: GAD . In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .

HY-N11756

Linearmycin A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.

Cat. No.	Product Name	Chemical Structure

HY-Y0367S

Maleic Acid-d2
Maleic Acid-d₂ is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].

HY-B0117S

Tigecycline-d9
Tigecycline-d₉ is deuterium labeled Tigecycline. Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2].

HY-118827S

Vedaprofen-d3
Vedaprofen-d₃ is the deuterium labeled Vedaprofen. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition [1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM[2].

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-W747491

Triclosan-13C12

Triclosan- ¹³C₁₂ is ¹³C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .

HY-W653962

Triclosan-13C6

Triclosan- ¹³C₆ is ¹³C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .

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