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By Research Areas:	Cancer (434) Cardiovascular Disease (44) Endocrinology (9) Infection (79) Inflammation/Immunology (193) Metabolic Disease (69) Neurological Disease (81)
Click Chemistry:	Labeling and Fluorescence Imaging (4) PROTAC Synthesis (1) Azide (5) Tetrazine (2) Alkynes (2)
Oligonucleotides:	Nucleotides and their Analogs (5) Cationic Lipids (3) Cap Analogs (1)

816

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126395

Patent Blue V calcium salt	Fluorescent Dye	Others
Patent Blue V calcium salt is a triarylmethane dye used for tissue staining and lymphatic tracing, mainly applied by topical injection or eye drops. Patent Blue V calcium salt has affinity for specific tissues (such as corneal endothelium, lymphatic system), and stains the target structure by adsorption or binding, assisting in precise operation during surgery. Patent Blue V calcium salt is mainly used in ophthalmic surgery (such as graft staining for Descemet's membrane endothelial keratoplasty) and lymphatic drainage localization for sentinel lymph node biopsy of tumors .

HY-W110929

Patent Blue V Acid blue 1	Fluorescent Dye	Cancer
Patent Blue V (Acid blue 1) is a novel biological dye that can be used as an intraocular dye for retinectomy. Retinectomy refers to the removal of the translucent inner limiting membrane (ILM). The application of appropriate dyes in vitreoretinal surgery can achieve the purpose of complete removal. Patent Blue V can be used to stain retinal premembranous structures. Spectral analysis shows that Patent Blue V has strong absorption below 450 nm and above 600 nm, showing a blue-green color. Patent Blue V is also used as a marker in lymphangiography for resection of neoplastic lymph nodes .

HY-131453A

Mitochondrial respiration-IN-1 hydrobromide	Mitochondrial Metabolism	Metabolic Disease
Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor (IC₅₀=8.8 mg/mL) extracted from patent US20110301180A1, compound 49. Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets .

HY-79369

Succinic anhydride 1 Publications Verification	ADC Linker	Cancer
Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide .

HY-126395R

Patent Blue V (calcium salt) (Standard)	Fluorescent Dye	Others
Patent Blue V (calcium salt) (Standard) is the analytical standard of Patent Blue V (calcium salt). This product is intended for research and analytical applications. Patent Blue V has been widely used in sentinel lymph node mapping. Patent Blue V is also a food coloring agent and an alternative dye for trypan blue (TB) in descemet membrane endothelial keratoplasty (DMEK) .

HY-U00054

LDL-IN-3	LDLR	Cardiovascular Disease Metabolic Disease
LDL-IN-3 is an anti-atherosclerotic compound extracted from patent WO/2005/039596A1, example C25 and patent US 6133467, example 3.

HY-U00243

Alpertine Win 31665	Others	Neurological Disease
Alpertine is an antipsychotic agent extracted from patent US 5955459 A.

HY-145589

Rafutrombopag Hetrombopag; SHR-8735	Thrombopoietin Receptor	Cardiovascular Disease
Rafutrombopag is a thrombopoietin (TPO) agonist extracted from patent CN113929668 A.

HY-100119A

Enecadin hydrochloride	Endogenous Metabolite	Cardiovascular Disease Neurological Disease
Enecadin hydrochloride is a neuroprotective agent extracted from patent US 8623823 B2.

HY-19497

Canosimibe AVE-5530; BART-1741	CETP	Metabolic Disease
Canosimibe is a cholesterol absorption inhibitor extracted from patent WO2004087655A1.

HY-100119

Enecadin	Calcium Channel	Cardiovascular Disease Neurological Disease
Enecadin is a neuroprotective agent extracted from patent US 8623823 B2.

HY-U00233

FG8119 NNC13-8119	GABA Receptor	Neurological Disease
FG8119 is a novel benzodiazepine agonist extracted from patent US 4745112 A.

HY-U00312

MEK-IN-1	MEK	Cancer
MEK-IN-1 is a MEK inhibitor extracted from patent WO2008076415A1.

HY-100124

Bamaluzole	GABA Receptor	Neurological Disease
Bamaluzole is a GABA receptor agonist extracted from patent WO 2012064642 A1.

HY-100154

Darenzepine	mAChR	Neurological Disease
Darenzepine is a muscarinic receptor inhibitor extracted from patent US 20170095465 A1.

HY-145497

Dipentamethylenethiuram Tetrasulfide	Biochemical Assay Reagents	Others
Dipentamethylenethiuram Tetrasulfide is a material for constructing rubber (extracted from patent CN112876756A) .

HY-U00320

Neurokinin antagonist 1	Neurokinin Receptor	Inflammation/Immunology Endocrinology
Neurokinin antagonist 1 is a Neurokinin antagonist extracted from patent WO1998045262A1.

HY-14802C

(+)-Talarozole	RAR/RXR Autophagy	Cancer
(+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1.

HY-132819

Ilunocitinib LY-3411067	JAK	Others
Ilunocitinib (compound 27) is a JAK inhibitor (extracted from patent WO2009114512A1) .

HY-103649

OT antagonist 3	Oxytocin Receptor	Endocrinology
OT antagonist 3 is an oxytocin (OT) antagonist extracted from patent WO2007017752A1.

HY-100172

Proteasome-IN-1	Proteasome	Cancer
Proteasome-IN-1 is a proteasome inhibitor extracted from patent WO 2013142376 A1.

HY-109073

Rovazolac ALX-101	LXR	Inflammation/Immunology
Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1.

HY-B1179

Dipyrocetyl	Others	Inflammation/Immunology
Dipyrocetyl is an anti-inflammatory and analgesic agent extracted from patent WO 2011132171 A1.

HY-108324

(Z)-Thiothixene	5-HT Receptor	Neurological Disease
(Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.

HY-14802D

(-)-Talarozole	RAR/RXR Autophagy	Cancer
(-)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1.

HY-101819

Antibacterial compound 1	Bacterial	Infection
Antibacterial compound 1 is a oxazolidinone extracted from patent WO1999037630A1 with antibacterial activities.

HY-P1445

HAEGTFTSDVSSYLE	GLP Receptor	Metabolic Disease
HAEGTFTSDVSSYLE is a polypeptide from patent CN 102920658 B. GLP-I analog contains the sequence.

HY-135596

Raloxifene dimethyl ester hydrochloride Diacyl-raloxifene hydrochloride; Raloxifene diacyl analog	Estrogen Receptor/ERR	Others
Raloxifene dimethyl ester hydrochloride is an analog of Raloxifene, extracted from patent US5464845A, compound 28 .

HY-79369S

Succinic anhydride-d4	Isotope-Labeled Compounds ADC Linker	Cancer
Succinic anhydride-d₄ is the deuterium labeled Succinic anhydride. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide .

HY-U00348

Anticonvulsant agent 1 4-(2,2-Difluoroethenyl)-α-ethyl-2-oxo-1-pyrrolidineacetamide	Others	Neurological Disease
Anticonvulsant agent 1 is an anticonvulsant agent extracted from patent WO2001062726A2, Compound 156.

HY-104028A

BAY 73-6691 racemate	Phosphodiesterase (PDE)	Neurological Disease
BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1.

HY-160705

PNI 132	Liposome	Cancer
PNI 132, an ionizable lipid derived from the patent WO2020252589A, is useful in the formulation of lipid nanoparticles.

HY-16564

Deferasirox (Fe3+ chelate)	Ferroptosis Bacterial	Others
Deferasirox Fe3+ Chelate is an iron chelating agent extracted from patent WO2003053986 .

HY-119864

Drinidene	Others	Neurological Disease
Drinidene can be used for the research of pain disorders extracted from patent AU2018254530A1 .

HY-79369S1

Succinic anhydride-13C2	ADC Linker	Cancer
Succinic anhydride- ¹³C₂ is the ¹³C labeled Succinic anhydride . Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide .

HY-79369R

Succinic anhydride (Standard)	Reference Standards ADC Linker	Cancer
Succinic anhydride (Standard) is the analytical standard of Succinic anhydride. This product is intended for research and analytical applications. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide .

HY-111471

JAK-IN-5	JAK	Inflammation/Immunology
JAK-IN-5 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.

HY-139773

Antibacterial agent 56	Bacterial	Infection Inflammation/Immunology
Antibacterial agent 56 (example 22) is a antibacterial agent (extracted from patent WO2013030735A1) .

HY-101750

Arrhythmias-Targeting Compound 1	Others	Cardiovascular Disease
Arrhythmias-Targeting Compound 1 is used in the research of arrhythmias, extracted from patent WO 2001028992 A2.

HY-139776

Antibacterial agent 59	Bacterial	Infection Inflammation/Immunology
Antibacterial agent 59 (example 24) is a antibacterial agent (extracted from patent WO2013030735A1) .

HY-139766

Antibacterial agent 49	Bacterial	Infection
Antibacterial agent 49 (example 12) is a antibacterial agent (extracted from patent WO2013030735A1) .

HY-139757

Antibacterial agent 40	Bacterial	Infection Inflammation/Immunology
Antibacterial agent 40 is an antibacterial agent (extracted from patent WO2015159265A1, compound C) .

HY-20588

CRAC intermediate 2	CRAC Channel	Others
CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1.

HY-100177

L-Threonine derivative-1	Amino Acid Derivatives	Others
L-Threonine derivative-1 is a acetylsalicylic-L-threonine ester extracted from patent US 20060287244 A1.

HY-139758

Antibacterial agent 41	Bacterial	Infection Inflammation/Immunology
Antibacterial agent 41 (example 3) is a antibacterial agent (extracted from patent WO2013030735A1) .

HY-U00378

Glycerol derivative 1	Drug Derivative	Cardiovascular Disease
Glycerol derivative 1 is a Glycerol derivative extracted from patent EP 672415 A1, compound (1).

HY-U00392

Tachykinin angatonist 1	Neurokinin Receptor	Neurological Disease Endocrinology
Tachykinin angatonist 1 is a neurokinin receptor antagonist extracted from patent US5968923, compound example 32.

HY-139769

Antibacterial agent 52	Bacterial	Infection Inflammation/Immunology
Antibacterial agent 52 (example 18) is a antibacterial agent (extracted from patent WO2013030735A1) .

HY-139771

Antibacterial agent 54	Bacterial	Infection Inflammation/Immunology
Antibacterial agent 54 (example 20) is a antibacterial agent (extracted from patent WO2013030735A1) .

HY-101730

Antibacterial compound 2	Bacterial	Infection
Antibacterial compound 2 is a useful antibacterial agent extracted from patent US5652238, compound example 9.

Cat. No.	Product Name

HY-L141

Off-patent Drug Library

2,770 compounds

Drug repurposing (also called drug repositioning, reprofiling, or re‑tasking) offers various advantages over developing an entirely new drug for a given indication, for example, lower risk of failure, less investment, and shorter development timelines. But drug repositioning projects are also subject to several risks, including regulatory and intellectual property issues. So the off-patent drugs are optimal for repositioning because of their immediate availability for clinical studies, with high feasibility and relatively low risk.

MCE carefully prepared a unique collection of 2,770 off-patent drugs, which is a good choice for drug repurposing.

Cat. No.	Product Name	Type

HY-130735

Janelia Fluor® 646, SE JF646, SE; JF646, NHS	Fluorescent Dyes/Probes
Janelia Fluor 646, SE (JF646, SE) is a red fluorescent dye can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-131020

Janelia Fluor® 525, SE JF525, SE; JF525, NHS	Fluorescent Dyes/Probes
Janelia Fluor 525, SE (JF525, SE) is a yellow fluorescent dye (Ex = 525 nm; Em = 549 nm) . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-131022

Janelia Fluor® 549 TFA JF549 TFA	Fluorescent Dyes/Probes
Janelia Fluor® 549 TFA (JF549 TFA) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-131029

Janelia Fluor® 646, Maleimide JF646, Maleimide	Fluorescent Dyes/Probes
Janelia Fluor® 646, Maleimide (JF646, Maleimide) is a red fluorescent dye that contains a maleimide group. JF646, Maleimide can be used in cellular imaging . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-131028

Janelia Fluor® 646 TFA JF646 TFA	Fluorescent Dyes/Probes
Janelia Fluor® 646 TFA (JF646 TFA), a red fluorogenic fluorescent dye, can be used in the synthesis of Janelia Fluor 646 HaloTag and SNAP-Tag ligands. JF646 TFA is used in live cell imaging experiments . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-D1500

Fluorescent NIR 885	Fluorescent Dyes/Probes
Fluorescent NIR 885 is a cyanine near-infrared-absorbing dye. Fluorescent NIR 885 can be used as a photoprotective agent (extracted from patent WO2014006589 compound 1-35) .

HY-131024

Janelia Fluor® 549, Tetrazine JF549, Tetrazine	Fluorescent Dyes/Probes
Janelia Fluor® 549, Tetrazine (JF549, Tetrazine) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-130736

Janelia Fluor® 549, SE JF549, SE; JF549, NHS	Fluorescent Dyes/Probes
Janelia Fluor® 549, SE (JF549, SE) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-131023

Janelia Fluor® 549, Maleimide TFA JF549, Maleimide TFA	Fluorescent Dyes/Probes
Janelia Fluor® 549, Maleimide TFA (JF549, Maleimide TFA) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-131026

Janelia Fluor® 635, SE JF635, SE; JF635, NHS	Dyes
Janelia Fluor® 635, SE (JF635, SE) is a red fluorogenic fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. JF635, SE can be used for live cell imaging . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-138658

Janelia Fluor® 526, SE

JF526, SE; JF526, NHS

Fluorescent Dyes/Probes

Janelia Fluor 526, SE (JF526,SE) is a fluorogenic yellow fluorescent dye that contains NHS ester group. JF526 is a versatile scaffold for fluorogenic ligands, including labels for genetically encoded self-labeling protein tags and stains for endogenous structures . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-131030

Janelia Fluor® 669, SE JF669, SE; JF669, NHS	Fluorescent Dyes/Probes
Janelia Fluor 669, SE (JF669, SE), a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm) . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-138659

Janelia Fluor® 646, Tetrazine

JF646, Tetrazine

Fluorescent Dyes/Probes

Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-131025

Janelia Fluor® 585, SE

JF585, SE; JF585, NHS

Fluorescent Dyes/Probes

Janelia Fluor 585, SE (JF585, SE) is an orange fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. Janelia Fluor 585, SE can be used immediately for structured illumination (SIM) and stimulated emission depletion (STED) imaging and could be converted to photoactivatable derivative for single-molecule localization microscopy (SMLM) experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-131021

Janelia Fluor® 549, Azide

JF549, Azide

Fluorescent Dyes/Probes

Janelia Fluor? 549, Azide (JF549, Azide) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor? products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-131027

Janelia Fluor® 646, Azide

JF646, Azide

Fluorescent Dyes/Probes

Janelia Fluor 646, Azide (JF646, Azide) is a red fluorogenic fluorescent dye containing a click chemistry group Azide. Janelia Fluor 646, Azide can be used for live-cell imaging experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-133535

PA Janelia Fluor® 646, SE

PA-JF646-NHS

Dyes

PA Janelia Fluor® 646, SE (PA-JF646-NHS), a photoactivatable fluorescent dye, is an NHS ester for coupling to primary amine groups. PA-JF646-NHS is non-fluorescent until activated at 365 nm. NHS ester can be converted to relevant substrate for use in self-labeling tag systems, e.g.HaloTag ^® and SNAP-tag ^®. PA-JF646-NHS is used for single molecule tracking and super resolution microscopy in live cells, specifically live cell sptPALM and fixed cell PALM. (λ_{Excitation/emission}~650/664 nm). Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

Cat. No.	Product Name	Type

HY-W110929

Patent Blue V

Acid blue 1

Biochemical Assay Reagents

Patent Blue V (Acid blue 1) is a novel biological dye that can be used as an intraocular dye for retinectomy. Retinectomy refers to the removal of the translucent inner limiting membrane (ILM). The application of appropriate dyes in vitreoretinal surgery can achieve the purpose of complete removal. Patent Blue V can be used to stain retinal premembranous structures. Spectral analysis shows that Patent Blue V has strong absorption below 450 nm and above 600 nm, showing a blue-green color. Patent Blue V is also used as a marker in lymphangiography for resection of neoplastic lymph nodes .

HY-139298

L319 1 Publications Verification Di((Z)-Non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate	Drug Delivery
L319 is an ionizable cationic lipidoid and can be used for synthetic liposomes, from the patent WO-2011153493-A2, compound 1 .

HY-W036733

4-Hydroxy-4-methylcyclohexanone	Biochemical Assay Reagents
4-Hydroxy-4-methylcyclohexanone is a useful synthetic reagent extracted from patent JP2009022162A. 4-Hydroxy-4-methylcyclohexanone can be used to synthesize trans-4-amino-1-methylcyclohexanol which is intermediate of pharmaceutical synthesis .

HY-132142

5-Propargylamino-dCTP

Gene Sequencing and Synthesis

5-Propargylamino-dCTP is a nucleoside molecule extracted from patent US9035035B2, compound dCTP-PA. 5-Propargylamino-dCTP can conjugate to molecular markers for use in nucleic acid labeling or sequence analysis . 5-Propargylamino-dCTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148830

Piperazine-bis(ethyl octadeca-9,12-dienoate)	Drug Delivery
Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).

HY-132138

5-Propargylamino-3'-azidomethyl-dCTP

Gene Sequencing and Synthesis

5-Propargylamino-3'-azidomethyl-dCTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 17. 5-Propargylamino-3'-azidomethyl-dCTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dCTP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-132137

5-Propargylamino-3'-azidomethyl-dUTP

Gene Sequencing and Synthesis

5-Propargylamino-3'-azidomethyl-dUTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 5. 5-Propargylamino-3'-azidomethyl-dUTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Target	Research Area

HY-P1445

HAEGTFTSDVSSYLE	GLP Receptor	Metabolic Disease
HAEGTFTSDVSSYLE is a polypeptide from patent CN 102920658 B. GLP-I analog contains the sequence.

HY-P1447

Exendin-3/4 (64-86)	Peptides	Metabolic Disease
Exendin-3/4 (64-86) is a polypeptide from patent CN 106029087 A. The incretin receptor ligands are derived from multiple skin toxicity Shan exosomes -3 skin of SDGTFTSDLSKQM Di EAVRLFIEWLKNGGPSSGAPPPS.

HY-P3377

Rimtoregtide	Peptides	Inflammation/Immunology
Rimtoregtide is a polypeptide compound which significantly reduces the increase in the levels of amylase and lipase in the blood caused by acute pancreatitis. Rimtoregtide has the potential for the research of pancreatitis and acute pancreatitis (extracted from patent WO2018205233A1).

HY-P1355A

Cyclosporin A-Derivative 1 Free base	Calcineurin Cyclophilin	Others
Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-160429

PSAR18-COOH	Drug Derivative	Others
PSAR18-COOH is a derivative of PSAR extracted from patent WO2009064913A1. PSAR is a highly hydrophilic, biodegradable, non-immunogenic and water-soluble polymer that has been employed in several delivery systems for drugs or diagnostics.

HY-103048A

PD-1/PD-L1-IN 3 TFA	PD-1/PD-L1	Cancer
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC₅₀s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases .

HY-P1355

Cyclosporin A-Derivative 1	Calcineurin Cyclophilin	Inflammation/Immunology
Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

HY-P3129

KRAS G13D peptide, 25 mer	Ras	Inflammation/Immunology Cancer
KRAS G13D peptide, 25 mer, a KRAS activating oncogene mutation peptide, is an immune potentiator extracted from patent WO2018144775A1. KRAS G13D peptide, 25 mer can be used to prepare KRAS vaccine .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9372

Crocetin β-D-glucopyranoside	Cardiovascular Disease Classification of Application Fields Neurological Disease Ketones, Aldehydes, Acids Source classification Rubiaceae Pigments Plants Gardenia jasminoides Ellis Disease Research Fields Food Research	Others
Crocetin β-D-glucopyranoside is an active part of saffron pigments extracted from patent CN 105935363 A .

HY-N3961

Neoglycyrol	Cardiovascular Disease Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.	Others
Neoglycyrol is isolated from the root of Glycyrrhiza uralensis Fisch . Neoglycyrol is a potential myocardial protection active compound screened from traditional patent medicine Tongmai Yangxin pill (TMYXP) .

HY-N10356

4,27-Dimethyl withaferin A	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	Others
4,27-Dimethyl withaferin A is a synthetic analog of withanolide natural products. 4,27-Dimethyl withaferin A has the potential for the research of neurodegenerative diseases (extracted from patent WO2015077780A1) .

Cat. No.	Product Name	Chemical Structure

HY-79369S

Succinic anhydride-d4
Succinic anhydride-d₄ is the deuterium labeled Succinic anhydride. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide .

HY-79369S1

Succinic anhydride-13C2
Succinic anhydride- ¹³C₂ is the ¹³C labeled Succinic anhydride . Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the proagent to an amine or hydroxy 1 group of a targeting polypeptide .

HY-139593S

Polθ-IN-1-d3
Polθ-IN-1-d3 (example 1) is a deuterated Polθ inhibitor used for cancer study (extracted from patent WO2021028670) .

HY-145552S

Azilsartan mepixetil-d5

Azilsartan mepixetil-d₅ (QR-01019-d₅) is deuterium labeled Azilsartan mepixetil. Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A) .

Cat. No.	Product Name		Classification

HY-U00318

JAK-IN-11		Alkynes
JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment . JAK-IN-11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132137B

5-Propargylamino-3'-azidomethyl-dUTP tristriethylamine		Azide
5-Propargylamino-3'-azidomethyl-dUTP tristriethylamine is a nucleotide molecule that can be used in DNA synthesis and DNA sequencing. For detailed information, refer to compound 5 in patent document WO2004018497A2. It contains an azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also react with molecules containing DBCO or BCN groups through strain-promoted alkyne-azide cycloaddition (SPAAC) .

HY-136857

BRD4 degrader-3		PROTAC Synthesis
BRD4 degrader-3 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC₅₀s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively . PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138659

Janelia Fluor® 646, Tetrazine JF646, Tetrazine		Tetrazine Labeling and Fluorescence Imaging
Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-131021

Janelia Fluor® 549, Azide JF549, Azide		Azide Labeling and Fluorescence Imaging
Janelia Fluor? 549, Azide (JF549, Azide) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor? products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-131027

Janelia Fluor® 646, Azide JF646, Azide		Azide Labeling and Fluorescence Imaging
Janelia Fluor 646, Azide (JF646, Azide) is a red fluorogenic fluorescent dye containing a click chemistry group Azide. Janelia Fluor 646, Azide can be used for live-cell imaging experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-131024

Janelia Fluor® 549, Tetrazine JF549, Tetrazine		Tetrazine Labeling and Fluorescence Imaging
Janelia Fluor® 549, Tetrazine (JF549, Tetrazine) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-147595

KRAS G12D inhibitor 15		Alkynes
KRAS G12D inhibitor 15 is a potent inhibitor of KRAS G12D. KRAS G12D inhibitor 15 has the potential for the research of various diseases or disorders, such as cancer or cancer metastasis (extracted from patent WO2022042630A1, compound 243) . KRAS G12D inhibitor 15 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132138

5-Propargylamino-3'-azidomethyl-dCTP		Azide
5-Propargylamino-3'-azidomethyl-dCTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 17. 5-Propargylamino-3'-azidomethyl-dCTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dCTP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-132137

5-Propargylamino-3'-azidomethyl-dUTP		Azide
5-Propargylamino-3'-azidomethyl-dUTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 5. 5-Propargylamino-3'-azidomethyl-dUTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-139298

L319 1 Publications Verification Di((Z)-Non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate		Cationic Lipids
L319 is an ionizable cationic lipidoid and can be used for synthetic liposomes, from the patent WO-2011153493-A2, compound 1 .

HY-132142

5-Propargylamino-dCTP		Nucleotides and their Analogs
5-Propargylamino-dCTP is a nucleoside molecule extracted from patent US9035035B2, compound dCTP-PA. 5-Propargylamino-dCTP can conjugate to molecular markers for use in nucleic acid labeling or sequence analysis . 5-Propargylamino-dCTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-132137B

5-Propargylamino-3'-azidomethyl-dUTP tristriethylamine		Nucleotides and their Analogs
5-Propargylamino-3'-azidomethyl-dUTP tristriethylamine is a nucleotide molecule that can be used in DNA synthesis and DNA sequencing. For detailed information, refer to compound 5 in patent document WO2004018497A2. It contains an azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also react with molecules containing DBCO or BCN groups through strain-promoted alkyne-azide cycloaddition (SPAAC) .

HY-132138A

5-Propargylamino-3'-azidomethyl-dCTP TEA		Nucleotides and their Analogs
5-Propargylamino-3'-azidomethyl-dCTP (TEA) is a nucleotide molecule that can be used in DNA synthesis and DNA sequencing. For detailed information, refer to compound 17 in patent document WO2004018497A2. 5-Propargylamino-3'-azidomethyl-dCTP (TEA) is a click chemistry reagent containing an azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also react with molecules containing DBCO or BCN groups through strain-promoted alkyne-azide cycloaddition (SPAAC) .

HY-160705

PNI 132		Cationic Lipids
PNI 132, an ionizable lipid derived from the patent WO2020252589A, is useful in the formulation of lipid nanoparticles.

HY-148830

Piperazine-bis(ethyl octadeca-9,12-dienoate)		Cationic Lipids
Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).

HY-164192

m7(3'AcmG)(5')ppp(5')(2'OMeA)pG ammonium		Cap Analogs
m7(3'AcmG)(5')ppp(5')(2'OMeA)pG ammonium, a cap analogue derived from patent WO2023159930A1, can be used for the synthesis of mRNA.

HY-132138

5-Propargylamino-3'-azidomethyl-dCTP		Nucleotides and their Analogs
5-Propargylamino-3'-azidomethyl-dCTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 17. 5-Propargylamino-3'-azidomethyl-dCTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dCTP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-132137

5-Propargylamino-3'-azidomethyl-dUTP		Nucleotides and their Analogs
5-Propargylamino-3'-azidomethyl-dUTP is a nucleoside molecule extracted from patent WO2004018497A2, compound 5. 5-Propargylamino-3'-azidomethyl-dUTP can be used in DNA synthesis and DNA sequencing . 5-Propargylamino-3'-azidomethyl-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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