1. Gene
  2. Kras - Kirsten rat sarcoma viral oncogene homolog Gene

Kras - Kirsten rat sarcoma viral oncogene homolog Gene

Mus musculus

Also known as ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras

Gene ID: 16653 | Gene type: protein coding

About Kras

Chromosome 6: 145,162,425-145,195,965 reverse strand.GRCm39:CM000999.3

This gene has 7 transcripts (splice variants), 201 orthologues, 35 paralogues and is associated with 90 phenotypes. Ubiquitous expression in CNS E18 (RPKM 17.), whole brain E14.5 (RPKM 16.2) and 26 other tissues.

Summary

Enables GTPase activity. Involved in endocrine signaling. Acts upstream of or within several processes, including forebrain astrocyte development; modulation of chemical synaptic transmission; and positive regulation of Rac protein signal transduction. Located in membrane. Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate Cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Kras Products(8)

mRNA Protein Name
NM_001403242.1 NP_001390171.1 GTPase KRas isoform 1
NM_001403245.1 NP_001390174.1 GTPase KRas isoform 3
NM_001403241.1 NP_001390170.1 GTPase KRas isoform 1
NM_001403246.1 NP_001390175.1 GTPase KRas isoform 4
NM_021284.7 NP_067259.4 GTPase KRas isoform 1
NM_001403243.1 NP_001390172.1 GTPase KRas isoform 2
NM_001403240.1 NP_001390169.1 GTPase KRas isoform 1
NM_001403244.1 NP_001390173.1 GTPase KRas isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activity IGI
IGI: Inferred from genetic interaction
15665300 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
12354753 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of Rac protein signal transduction IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within Ras protein signal transduction IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
22577135 MGI
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IDA
IDA: Inferred from direct assay
24058167 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IGI
IGI: Inferred from genetic interaction
24058167 MGI
acts upstream of or within forebrain astrocyte development IMP
IMP: Inferred from mutant phenotype
22577135 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
29191600 MGI
acts upstream of glial cell proliferation IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within homeostasis of number of cells within a tissue IGI
IGI: Inferred from genetic interaction
24675817 MGI
acts upstream of or within negative regulation of epithelial cell differentiation IDA
IDA: Inferred from direct assay
24058167 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10845775 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10845775 MGI
acts upstream of or within positive regulation of Rac protein signal transduction IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22577135 MGI
acts upstream of or within positive regulation of glial cell proliferation IGI
IGI: Inferred from genetic interaction
15665300 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IGI
IGI: Inferred from genetic interaction
11793011 MGI
acts upstream of or within regulation of synaptic transmission, GABAergic IGI
IGI: Inferred from genetic interaction
11793011 MGI
acts upstream of or within skeletal muscle cell differentiation IGI
IGI: Inferred from genetic interaction
15542848 MGI
acts upstream of or within striated muscle cell differentiation IGI
IGI: Inferred from genetic interaction
15542848 MGI
acts upstream of type I pneumocyte differentiation IDA
IDA: Inferred from direct assay
24058167 MGI
acts upstream of or within visual learning IGI
IGI: Inferred from genetic interaction
11793011 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
10085069 MGI
located in membrane IGI
IGI: Inferred from genetic interaction
14966563 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kras Protein Structure

H_N_K_Ras_like

H_N_K_Ras_like: cd04138 (2 - 163)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

GTPase KRas

Kirsten rat sarcoma oncogene 2, expressed

p21 protein

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Orthologs Information

Species Symbol Source ID
Homo sapiens Kras NCBI NCBI:3845