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Pathways Recommended: Apoptosis
Results for "

apoptosis promoting

" in MedChemExpress (MCE) Product Catalog:

356

Inhibitors & Agonists

2

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4

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17

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1

Inhibitory Antibodies

77

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6

Isotope-Labeled Compounds

49

Click Chemistry

53

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W021040

    CGA-173506

    Fungal Apoptosis Infection Cancer
    Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells .
    Fludioxonil
  • HY-116147

    LPL Receptor Apoptosis Cancer
    Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity .
    Ceranib-2
  • HY-N0839
    Quillaic acid
    1 Publications Verification

    Quillaja sapogenin

    Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Quillaic acid (Quillaja sapogenin)It is an anti-gastric cancer and anti-proliferation agent that can promote apoptosis of cancer cells. (apoptosis). Quillaic acidAlso has analgesic and local anti-inflammatory activity .
    Quillaic acid
  • HY-124584
    Minnelide
    2 Publications Verification

    Apoptosis Cancer
    Minnelide is a prodrug of triptolide that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide promotes apoptosis .
    Minnelide
  • HY-115865
    XIAP degrader-1
    1 Publications Verification

    IAP Cancer
    XIAP degrader-1, a primary amine tethered small molecule, promotes the degradation of X-linked inhibitor of apoptosis protein (XIAP).
    XIAP degrader-1
  • HY-128777
    WEHI-9625
    1 Publications Verification

    VDAC Apoptosis Cancer
    WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX .
    WEHI-9625
  • HY-111299

    Apoptosis Cancer
    Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of FOXO1, leading to cell cycle arrest and apoptosis, and can be used in cancer research .
    Psammaplysene A
  • HY-163456

    Apoptosis Cancer
    Chx-HT has an anti-proliferation activity and promotes apoptosis on ovarian cancer cells .
    Chx-HT
  • HY-P3867

    Orexin Receptor (OX Receptor) Apoptosis Cancer
    Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis .
    Hypocretin (70-98), human
  • HY-124624

    Microtubule/Tubulin Apoptosis Cancer
    PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells .
    PBOX-15
  • HY-163566

    Apoptosis Cancer
    Apoptosis inducer 18, a potent inducer of apoptosis, shows significant cytotoxicity to the breast cancer cell line MCF-7 (IC50=0.559 μM). Apoptosis inducer 18 inhibits cell cycle progression and promotes apoptosis by binding to DNA and causing damage, and by binding to the active site of CDK-2, interfering with its kinase activity. Apoptosis inducer 18 can be used in anti-breast cancer research .
    Apoptosis inducer 18
  • HY-12294B

    (Rac)-NVP-AAM077

    iGluR Caspase Apoptosis Neurological Disease
    (Rac)-PEAQX is a NMDA receptor agonist. (Rac)-PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures .
    (Rac)-PEAQX
  • HY-149997

    Bacterial Reactive Oxygen Species Apoptosis Cancer
    Anticancer agent 120 (compound 21) is an N-acylated ciprofloxacin derivative, which has certain antibacterial activity and induces ROS to promote cancer cell apoptosis .
    Anticancer agent 120
  • HY-169124

    Apoptosis Reactive Oxygen Species Protease Activated Receptor (PAR) Bcl-2 Family Cancer
    Apoptosis Inducer 28 (Compound X1) is an apoptosis-inducing agent with anticancer activity in vitro. Apoptosis Inducer 28 can arrest the cell cycle at the G1 phase, promote cell death, and induce apoptosis by disrupting mitochondrial membrane potential. Apoptosis inducer 28 can also decrease the production of reactive oxygen species, downregulate the gene expression of BAX, Bcl-xL, and Bcl-2, while upregulating the gene expression of PAR-4 .
    Apoptosis inducer 28
  • HY-154862

    Apoptosis Infection Cancer
    Anticancer agent 119 (compound 15) is an N-acylated ciprofloxacin derivative, which has certain antibacterial activity and induces ROS production to promote cancer cell apoptosis .
    Anticancer agent 119
  • HY-122041

    Apoptosis Poly(ADP-ribose) Glycohydrolase (PARG) Cancer
    Ethacridine is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor and an activator of the transcriptional coactivator. Ethacridine induces thyroid cancer cells apoptosis and promotes differentiation in thyroid follicular cells .
    Ethacridine
  • HY-101002

    SarCNU; Sarmustine

    Apoptosis DNA Alkylator/Crosslinker Cancer
    Sarcosinamide chloroethylnitrosourea is an orally active alkylating agent. Sarcosinamide chloroethylnitrosourea can induce apoptosis by promoting DNA alkylation. Sarcosinamide chloroethylnitrosourea can be used in cancer-related research .
    Sarcosinamide chloroethylnitrosourea
  • HY-N6074

    Autophagy Apoptosis Inflammation/Immunology Cancer
    Soyasapogenol B is a component of soy that has oral activity. Soyasapogenol B promotes autophagy and apoptosis. Soyasapogenol B has anti-inflammatory, antioxidant and antitumor activities .
    Soyasapogenol B
  • HY-156467

    NVL-655

    Anaplastic lymphoma kinase (ALK) Apoptosis Cancer
    Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity .
    Neladalkib
  • HY-W014507

    Claudin Cancer
    9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis .
    9,10-Phenanthrenequinone
  • HY-13917A
    PND-1186 hydrochloride
    10+ Cited Publications

    VS-4718 hydrochloride; SR-2516 hydrochloride

    FAK Apoptosis Cancer
    PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis .
    PND-1186 hydrochloride
  • HY-B1461

    Tyrosinase Apoptosis Cancer
    Deoxyarbutin is an orally active tyrosinase inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity [1][2][3].
    Deoxyarbutin
  • HY-N8034

    Apoptosis Autophagy Cancer
    Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer .
    Glychionide A
  • HY-152156

    Microtubule/Tubulin Apoptosis Cancer
    Tubulin inhibitor 11 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis .
    Tubulin inhibitor 11
  • HY-13917
    PND-1186
    10+ Cited Publications

    VS-4718; SR-2516

    FAK Apoptosis Cancer
    PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis .
    PND-1186
  • HY-124584A

    Apoptosis Cancer
    Minnelide free base is a prodrug of Triptolide (HY-32735) that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide free base promotes apoptosis .
    Minnelide free base
  • HY-W127433

    Apoptosis Interleukin Related Inflammation/Immunology
    Isostearic acid is a unique fatty acid. Isostearic acid promotes IL-1 release and Apoptosis. Isostearic acid has potent inflammatory properties. Isostearic acid can be used in pharmaceutical, personal care, and cosmetic applications .
    Isostearic acid
  • HY-146245C
    ODN 1826 sodium
    3 Publications Verification

    CpG 1826 sodium

    Toll-like Receptor (TLR) Apoptosis Cardiovascular Disease Cancer
    ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) that is a TLR9 agonist. ODN 1826 sodium is an immunostimulatory agent that induces NO and iNOS production in mouse models. ODN 1826 sodium also enhances apoptosis (apoptosis) and may promote atherosclerosis. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’ .
    ODN 1826 sodium
  • HY-137977
    DMU-212
    2 Publications Verification

    ERK Apoptosis Cancer
    DMU-212 is a methylated derivative of Resveratrol (HY-16561), with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2 protein. DMU-212 has orally active .
    DMU-212
  • HY-103349
    PETCM
    1 Publications Verification

    Caspase Apoptosis Cancer
    PETCM is an activator of?caspase-3 and acts as an cytochrome?c?(cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells .
    PETCM
  • HY-108664

    P2Y Receptor Metabolic Disease
    MRS2957 is a P2Y6 receptor agonist that activates AMPK in pancreatic β-cells, promoting insulin secretion and reducing apoptosis, thereby holding potential as a therapeutic target for type 2 diabetes.
    MRS2957
  • HY-113127

    Apoptosis Others
    L-Tryptophanamide is a compound discovered in wet age-related macular degeneration research, which has activities related to affecting retinal cell proliferation, apoptosis, necrosis and angiogenesis. In in vitro experiments, L-Tryptophanamide affects the proliferation, apoptosis and necrosis of human retinal pigment epithelial cells, and promotes tube formation and migration of human retinal endothelial cells.
    L-Tryptophanamide
  • HY-152135

    Apoptosis Cancer
    TJ08, a 1,2,5-trisubstituted benzimidazole derivative, efficiently induces G1/S phase arrest and promotes apoptosis in various cancer cells. TJ08 is an anticancer agent .
    TJ08
  • HY-107616
    H2L5186303
    2 Publications Verification

    LPL Receptor Apoptosis Others
    H2L5186303 is an effective and selective LPA2 receptor antagonist, with an IC50 of 9 nM, and it has anti-inflammatory effects. H2L5186303 can inhibit intestinal cell proliferation and promote apoptosis .
    H2L5186303
  • HY-N9647

    Wnt β-catenin Apoptosis Cancer
    Dalbinol is a rotenoid compound. Dalbinol can inhibit Wnt/β-catenin signaling pathway and promote β-catenin degradation. Dalbinol inhibits tumor cells proliferation and induces apoptosis. Dalbinol has antitumor activity .
    Dalbinol
  • HY-136829

    Apoptosis Others
    BPH-675 is a large bisphosphonate inhibitor with long hydrophobic side chains and a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor with an IC50 of 0.71 μM. GGPPS inhibitor promotes HUVEC apoptosis .
    BPH-675
  • HY-13768C

    SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate

    Topoisomerase Apoptosis Autophagy Cancer
    Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity .
    Topotecan hydrochloride hydrate
  • HY-155122

    PARP Cancer
    PARP-1-IN-13 (Compound 19c) is a PARP-1 inhibitor (IC50: 26 nM). PARP-1-IN-13 inhibits DNA single-strand breakage repair and aggravates DNA double-strand breakage. PARP-1-IN-13 promotes the apoptosis of cancer cells through the mitochondrial apoptosis pathway .
    PARP-1-IN-13
  • HY-168863

    PROTACs HDAC Apoptosis Cancer
    FF2049 is a selective HDAC PROTAC degrader (DC50 = 257 nM for HDAC1). FF2049 promotes ubiquitination and degradation of HDAC. FF2049 promotes Apoptosis. FF2049 can be used for the research of hematological and solid cancer (Pink: POI ligand 1 (HY-168864); Blue: E3 ligase FEM1B ligand (HY-168865)) .
    FF2049
  • HY-110339
    RKI-1447 dihydrochloride
    3 Publications Verification

    ROCK Apoptosis Cancer
    RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively . RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis .
    RKI-1447 dihydrochloride
  • HY-P1687

    Bacterial Apoptosis Cancer
    Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes apoptosis .
    Siomycin A
  • HY-162325

    Aldose Reductase Mitochondrial Metabolism Apoptosis Mitophagy Metabolic Disease
    WJ-39 is an orally active aldose reductase (AR) inhibitor. WJ-39 improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy, and attenuating apoptosis .
    WJ-39
  • HY-P3707

    Apoptosis Cancer
    Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice .
    Tumor targeted pro-apoptotic peptide
  • HY-N6952
    Geraniol
    1 Publications Verification

    Fungal Endogenous Metabolite Apoptosis Bacterial Infection Metabolic Disease Inflammation/Immunology Cancer
    Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes .
    Geraniol
  • HY-107796

    COX Apoptosis Inflammation/Immunology
    Metamizol magnesium is an orally active cyclooxygenase (COX) inhibitor. Metamizole magnesium can inhibit cell proliferation and promote cell apoptosis. Metamizole magnesium has anti-inflammatory and antioxidant activities. Metamizole magnesium is an antipyretic, analgesic and spasmolytic agent .
    Metamizol magnesium
  • HY-125522

    ERK Apoptosis Inflammation/Immunology
    Methyl helicterate is a triterpenoid, that can be isolated from Helicteres angustifolia (Sterculiaceae). Methyl helicterate inhibits hepatic stellate cell activation and promotes cell apoptosis through downregulating the ERK1/2 signaling pathway .
    Methyl helicterate
  • HY-116692

    Apoptosis Caspase Mitochondrial Metabolism PARP DNA/RNA Synthesis
    Apoptosis inducer 34 (Compound 4) is a small molecule compound that induces apoptosis by directly activating the intrinsic apoptotic pathway. Apoptosis inducer 34 promotes Apaf-1 oligomerization to form mature apoptosomes, thereby activating caspase-9 and caspase-3. It significantly activates the apoptotic pathway in Jurkat cells by enhancing the cytochrome c-dependent apoptotic signaling pathway, inducing PARP cleavage and chromosomal DNA fragmentation. Furthermore, Apoptosis inducer 34 exhibits low toxicity to normal cells, demonstrating potential for selective targeting of cancer cells. Apoptosis inducer 34 is a promising candidate for studying cancer related to apoptotic pathways .
    Apoptosis inducer 34
  • HY-10222
    Ixabepilone
    5 Publications Verification

    BMS-247550; Aza-epothilone B

    Microtubule/Tubulin Apoptosis Bacterial Cancer
    Ixabepilone (BMS-247550) is an orally bioavailable?microtubule?inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.
    Ixabepilone
  • HY-156467A

    NVL-655 TFA

    Anaplastic lymphoma kinase (ALK) Apoptosis Cancer
    Neladalkib TFA is the TFA salt form of Neladalkib (HY-156467). Neladalkib (NVL-655) is an oral ALK inhibitor, the IC50 for Neladalkib in inhibiting ALK is 2.8 nM. Neladalkib promotes cell apoptosis and has anti-tumor activity .
    Neladalkib TFA
  • HY-12468
    A-1210477
    15+ Cited Publications

    Bcl-2 Family Apoptosis Cancer
    A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM . A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner .
    A-1210477

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