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Inhibitory effect

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Macrophage migration inhibitory factor (MIF) (2) 17β-HSD (1) 5-HT Receptor (6) Acyltransferase (1) Adenosine Deaminase (3) Adenosine Receptor (2) Adrenergic Receptor (1) Akt (4) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (4) Aminoacyl-tRNA Synthetase (1) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (3) Androgen Receptor (2) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (20) Antifolate (1) Apelin Receptor (APJ) (1) Apoptosis (38) Arrestin (1) Aryl Hydrocarbon Receptor (3) ATM/ATR (1) ATP Synthase (3) Autophagy (20) Bacterial (40) Bcl-2 Family (1) Beta-secretase (2) Biochemical Assay Reagents (6) Btk (2) c-Fms (1) c-Kit (1) Calcium Channel (10) Carbonic Anhydrase (1) Carboxylesterase (1) Casein Kinase (2) Caspase (2) Cathepsin (1) CCR (4) CD3 (1) CDK (9) CETP (1) Checkpoint Kinase (Chk) (1) Chloride Channel (1) Cholecystokinin Receptor (2) Cholinesterase (ChE) (6) COX (18) CRFR (1) CXCR (2) Cytochrome P450 (12) Dengue virus (3) Dihydrofolate reductase (DHFR) (1) Dipeptidyl Peptidase (1) DNA-PK (2) DNA/RNA Synthesis (7) Dopamine Receptor (1) Drug Isomer (1) Drug Metabolite (2) Dynamin (2) E1/E2/E3 Enzyme (2) EBV (1) EGFR (3) Elastase (4) Endogenous Metabolite (38) Endothelin Receptor (2) Enterovirus (3) Epigenetic Reader Domain (4) ERK (5) Estrogen Receptor/ERR (4) FAK (2) FAP (3) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (1) Flavivirus (3) FLT3 (1) Fluorescent Dye (4) Fungal (24) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (7) GLP Receptor (1) Glucokinase (1) GLUT (1) Glutaminase (1) Glycosidase (4) Glycosyltransferase (1) Glyoxalase (GLO) (1) GnRH Receptor (1) HBV (1) HCV (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (3) Histamine Receptor (3) Histone Acetyltransferase (1) Histone Demethylase (1) Histone Methyltransferase (6) HIV (12) HIV Protease (1) HMG-CoA Reductase (HMGCR) (1) HSV (1) IFNAR (1) iGluR (3) Influenza Virus (9) Insecticide (2) Insulin Receptor (1) Integrin (1) Interleukin Related (6) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (10) JAK (2) JNK (3) Keap1-Nrf2 (4) Leukotriene Receptor (1) Ligands for Target Protein for PROTAC (1) Lipase (2) Lipoxygenase (5) LRRK2 (1) mAChR (2) MAPKAPK2 (MK2) (1) MDM-2/p53 (1) MEK (1) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) mGluR (3) Microtubule/Tubulin (3) Mitochondrial Metabolism (4) Mitophagy (3) MMP (1) Monoamine Oxidase (7) mTOR (1) Myosin (1) Na+/K+ ATPase (1) Neurokinin Receptor (2) NF-κB (12) NO Synthase (15) NOD-like Receptor (NLR) (1) Opioid Receptor (3) P-glycoprotein (1) P2X Receptor (1) p38 MAPK (4) p62 (1) PAK (1) Parasite (11) PD-1/PD-L1 (3) PERK (2) PGE synthase (2) Phosphatase (7) Phosphodiesterase (PDE) (9) Phospholipase (2) Photosystem II (3) PI3K (7) Pim (2) PINK1/Parkin (1) PKA (6) PKC (7) Platelet-activating Factor Receptor (PAFR) (2) Potassium Channel (6) Progesterone Receptor (1) Prostaglandin Receptor (2) PROTACs (3) Proteasome (2) Protein Arginine Deiminase (1) Proton Pump (2) PSMA (1) PTEN (2) Raf (2) RANKL/RANK (1) Ras (3) Reactive Oxygen Species (4) RET (1) Reverse Transcriptase (1) ROCK (6) SARS-CoV (1) SGLT (1) SHP2 (2) Sirtuin (1) Sodium Channel (9) Src (1) STAT (1) Survivin (1) Telomerase (2) TGF-beta/Smad (6) TGF-β Receptor (1) Thymidylate Synthase (2) Tie (1) TNF Receptor (6) Topoisomerase (5) Transketolase (1) Transmembrane Glycoprotein (1) Trk Receptor (2) Tyrosinase (4) VEGFR (8) Wnt (2) YAP (4) α-synuclein (1) β-catenin (1)
By Research Areas:	Cancer (190) Cardiovascular Disease (25) Endocrinology (12) Infection (105) Inflammation/Immunology (108) Metabolic Disease (31) Neurological Disease (75)
Click Chemistry:	Azide (3) Alkynes (2)
Oligonucleotides:	Fillers (1)

489

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

141

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Macrophage migration inhibitory factor (MIF)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162003A

DCPT1061 hydrochloride	Histone Methyltransferase	Cancer
DCPT1061 hydrochloride has a strong inhibitory effect on PRMT1, PRMT6, and PRMT8 in vitro, The epigenetic enzymes such as PRMT3, PRMT4 and PRMT5 had little inhibitory effect. DCPT1061 hydrochloride has antitumor effects .

HY-W041498

4-O-Methyldopamine hydrochloride	Dihydrofolate reductase (DHFR)	Neurological Disease
4-O-Methyldopamine hydrochloride is a catecholamine compound that has an inhibitory effect on dihydropteridine reductase .

HY-159819

Vormatrigine	Sodium Channel	Neurological Disease
Vormatrigine is an orally active sodium channel inhibitor with anti-epileptic activity. Vormatrigine has a specific inhibitory effect on overactive NaV channels in vitro and has a good inhibitory effect in the maximal electroconvulsive seizure (MES) model. Vormatrigine can be used to study human focal and generalized epilepsy .

HY-P1083

Dynamin inhibitory peptide 1 Publications Verification	Dynamin	Neurological Disease
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors .

HY-115312

Ro 18-5364	Na+/K+ ATPase	Others
Ro 18-5364 is an inhibitor of gastric H+/K+ ATPase, which has the effect of inhibiting the activity of the enzyme. Ro 18-5364 has a very strong inhibitory effect on gastric mucosal H+/K+ ATPase, and the inhibitory effect is more significant at low pH. At the same time, there is no selectivity difference between the two enantiomers of H+/K+ ATPase, and its inhibitory effect can be studied and verified by a variety of experimental methods, including inhibition of enzyme activity, proton transport, and studies on its binding.

HY-N3226

Myricananin A	NO Synthase	Inflammation/Immunology
Myricananin A is a colorless needle that has inhibitory effect on iNOS .

HY-162130

Antibacterial agent 176	Bacterial	Infection
Antibacterial agent 176 (Compound 6f) is a potent PqsR antagonist. Antibacterial agent 176 has a good inhibitory effect on P. aeruginosa CF, and a significant inhibitory effect on the production of pyocyanin, 2-alkyl-4 (1H) -quinolones .

HY-P10106

TAT-PAK18 inhibitory peptide	PAK	Cancer
TAT-PAK18 inhibitory peptide is a membrane-permeable PAK inhibitory peptide. TAT-PAK18 inhibitory peptide reduces F-actin clusters and occludes the effect of Shank3 knockdown .

HY-156359

Tuberculosis inhibitor 10	Others	Others
Tuberculosis inhibitor 10 shows moderate inhibitory effect on the enzymatic activity of MSMEG_6649. Tuberculosis inhibitor 10 enhances the inhibitory activity of PAS against mycobacteria .

HY-D0205

(RS)-Carbocisteine S-(Carboxymethyl)-DL-cysteine	Biochemical Assay Reagents	Others
(RS)-Carbocisteine is the S-carboxymethyl cysteine with no detectable inhibitory effect. (RS)-Carbocisteine is the inactive enantiomer of Carbocisteine.

HY-117012

NE58018	Endogenous Metabolite	Others
NE58018 is a compound with bone resorption inhibitory activity. NE58018 exerts its effect by affecting the action of Farnesyl pyrophosphate synthase (FPPS). The structural features of NE58018 combined with aminophosphonates significantly enhance its inhibitory activity. NE58018 affects the roles of Thr201 and Tyr204 residues in substrate binding and catalysis. The interaction of NE58018 enhances the inhibitory effect on the target enzyme .

HY-P1083A

Dynamin inhibitory peptide TFA	Dynamin	Neurological Disease
Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D₃ effect on GABA_A receptors .

HY-121610

FR-202306	Bacterial Antibiotic	Others
FR-202306 is a compound with antibacterial and peptide deformylase inhibitory activities, isolated from microorganisms, which has an inhibitory effect on the peptide deformylase of Staphylococcus aureus and also has antibacterial activity.

HY-N11566

(+)-Oxypeucedanin methanolate	Prostaglandin Receptor	Inflammation/Immunology
(+)-Oxypeucedanin methanolate (compound 9) is a natural compound with inhibitory effect on prostaglandin E2 production .

HY-N10024

Ganolactone Ganolactone A	EBV	Infection
Ganolactone is a triterpenoid compound. Ganolactone has a weak inhibitory effect on EBV early antigen .

HY-N7962

Cornoside	Aldose Reductase	Inflammation/Immunology
Cornoside is a phenolic glycoside and has inhibitory effect on rat lens aldose reductase (AR) with an IC₅₀ of 150 μM .

HY-107421

Prostratin	PKC HIV	Infection Cancer
Prostratin, a natural terpenoid compound, is a PKC activator, with a K_i of 12.5 nM and shows inhibitory effect on HIV-1.

HY-112624

Dextran Dextran 40	Bacterial	Cardiovascular Disease Cancer
Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.

HY-129422

Diallyl G	Opioid Receptor	Neurological Disease
Diallyl G is a delta-opioid receptor antagonist. Diallyl G shows inhibitory effect on GTPase .

HY-168163

CDK12/13 ligand 1	CDK	Cancer
ALK-IN-29 (compound 4c) has a certain inhibitory effect on tyrosine protein kinases ALK, CDK2/CyclinE1 and FAK, among which the strongest inhibitory effect on ALK kinase is 40.63% at a concentration of 10 μM. ALK-IN-29 can be used for anti-cancer research .

HY-168513

ALK-IN-29	Anaplastic lymphoma kinase (ALK) CDK FAK	Cancer
ALK-IN-29 (compound 4c) has a certain inhibitory effect on tyrosine protein kinases ALK, CDK2/CyclinE1 and FAK, among which the strongest inhibitory effect on ALK kinase is 40.63% at a concentration of 10 μM. ALK-IN-29 can be used for anti-cancer research .

HY-121328

Empenthrin S-2852F	Parasite	Infection Neurological Disease
Empenthrin (S-2852F) is a synthetic pyrethroid. Empenthrin can be used in insecticides. Empenthrin shows a clear species-specificity in the inhibitory effect on the Pentobarbital (PTB)-metabolizing enzyme(s). Empenthrin prolongs PTB induced-sleeping time in mice through an inhibition of the PTB-metabolizing enzyme(s) in the liver, an effect that does not occur in rats. Empenthrin shows a clear species-specificity in the inhibitory effect on the PTB-metabolizing enzyme(s) .

HY-18996

Adjudin 3 Publications Verification AF-2364	Chloride Channel Mitochondrial Metabolism	Cancer
Adjudin is an extensively studied male contraceptive with a superior *mitochondria*-inhibitory effect. Adjudin is also a potent Cl ^- channel blocker.

HY-N9092

Geranyl ferulate (E)-geranylferulic acid	NO Synthase	Infection Inflammation/Immunology
Geranyl ferulate ((E)-geranylferulic acid), isolated from Zingiber officinale, exhibits inhibitory effect on the production of nitric oxide (NO) .

HY-N3231

Murraol CM-c2	Lipoxygenase COX	Cancer
Murraol (CM-c2), a coumarin, can be isolated from the leaves of Madagascar pine cork (Apiaceae). Murraol has cyclooxygenase (COX) and lipoxygenase inhibitory properties and has an inhibitory effect on the growth of cancer cells .

HY-N2111

Momordicoside A	Phosphatase	Metabolic Disease
Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on protein tyrosine phosphatase (PTP1B) .

HY-N6069

Raspberry ketone glucoside 1 Publications Verification	Others	Inflammation/Immunology
Raspberry ketone glucoside is a natural product in raspberry fruit. Raspberry ketone glucosidev has the inhibitory effect on the melanin synthesis .

HY-151231

6-Hydroxyluteolin	Aldose Reductase	Others
6-Hydroxyluteolin (Compound 17) is a flavonoid compound. 6-Hydroxyluteolin has an inhibitory effect on aldose reductase (AR) .

HY-136666

Antibiotic AC4437	Bacterial	Others
Antibiotic AC4437 is a compound with antimicrobial activity isolated from specific soil microorganisms and has an inhibitory effect on Bacillus subtilis.

HY-170847

Anti-MRSA agent 24	Bacterial	Others
Anti-MRSA agent 24 is an antimicrobial agent that targets MRSA and has a significant inhibitory effect on penicillin-resistant Staphylococcus aureus.

HY-136634

BTM-1042	Others	Others
BTM-1042 is a newly synthesized compound with antispasmodic effects. It can inhibit the twitch reaction of the guinea pig ileum under electrical stimulation and is not affected by naloxone. It has similar effects to atropine and can block muscarinic receptors, but has less effect on other types of receptors. BTM-1042 also has an inhibitory effect on the ileal reaction caused by nicotine and 5-hydroxytryptamine. BTM-1042 showed a dose-dependent inhibitory effect on the spontaneous movement of the rabbit stomach. In general, BTM-1042 is a agent with a strong antispasmodic effect.

HY-W178011

Topoisomerase IIα-IN-9 4,4'-Sulfonylbis(2-methylphenol)	Topoisomerase	Cancer
Topoisomerase IIα-IN-9 (NSC85582) is a bisphenol compound that has a moderate inhibitory effect on DNA topoisomerase Topoisomerase II (IC₅₀: 571 μM). Topoisomerase IIα-IN-9 also exhibits a certain cell growth inhibitory effect, with IC₅₀s of 117 μM and 218 μM for K562 and CHO, respectively .

HY-161362

SR-3-65	PI3K	Cancer
SR-3-65 (compound 6) is a Indisulam (HY-13650) derivative,and inhibits the migration of gastric cancer cells. SR-3-65 attenuates PI3K/AKT/GSK-3β/β-catenin signaling pathway .

HY-158017

WXM-1-170	PI3K	Cancer
WXM-1-170 (compound 10) is a Indisulam (HY-13650) derivative,and inhibits the migration of gastric cancer cells. WXM-1-170 attenuates PI3K/AKT/GSK-3β/β-catenin signaling pathway .

HY-125112

Vicenin-1	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Vicenin 1 is a C-glycosylflavone that has an inhibitory effect on angiotensin-converting enzyme (ACE)(IC₅₀=52.50 μM) .

HY-116885

Thunalbene	NO Synthase	Inflammation/Immunology
Thunalbene is a stilbene derivative isolated from Thunia alba. Thunalbene has a weak inhibitory effect on nitric oxide production and is not cytotoxic .

HY-142013

Blestriarene B (-)-Blestriarene B	Microtubule/Tubulin	Others
Blestriarene B ((-)-Blestriarene B) a stilbenoid isolated by the guidance of inhibitory effect of tubulin polymerization from the tubers of Bletilla striata (Orchidaceae) .

HY-116923

p18SMI-21	Endogenous Metabolite	Metabolic Disease
p18SMI-21 is a novel INK4C inhibitor that specifically blocks the biological activity of p18 protein. p18SMI-21 exerts its anti-gastric acid effect through direct contact, and the intensity of this effect varies with the dose. p18SMI-21 can significantly reduce the proteolytic activity of pepsin under certain conditions. The inhibitory effect of p18SMI-21 is best achieved in direct contact with the substrate. If it contacts the substrate first, the inhibitory effect will be lost .

HY-W009177

S-Methylglutathione	Glyoxalase (GLO)	Others
S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH . S-Methylglutathione has inhibitory effect on glyoxalase 1 .

HY-N11443

Acetyllycoposerramine M	Others	Neurological Disease
Acetyllycoposerramine M is a lycopodine-type alkaloid, which can be isolated from Lycopodium japonicum. But Acetyllycoposerramine M has no inhibitory effect on acetylcholinesterase .

HY-N3788

Dulcioic acid	Others	Inflammation/Immunology
Dulcioic acid (compound 19) is a product isolated from Tripterygium wilfordii Hook f. Dulcioic acid shows a significant inhibitory effect on cytokine production .

HY-W596782

Chaetochromin A Chaetochromin	Others	Neurological Disease
Chaetochromin A (Compound 1) is a fungal metabolite. Chaetochromin A shows inhibitory effect on botulinum neurotoxin serotype A (BoNT A) (IC₅₀= 24.6 μM) .

HY-162003

DCPT1061	Histone Methyltransferase	Cancer
DCPT1061 potently inhibits PRMT1, PRMT6 and PRMT8 in vitro with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. DCPT1061 has antitumor effect .

HY-118142

4-Nitrobenzofuroxan	HIV	Infection
4-Nitrobenzofuroxan is an antiviral compound with HIV-1 inhibitory activity. 4-Nitrobenzofuroxan also exhibits an inhibitory effect on IDO1. The application potential of 4-Nitrobenzofuroxan lies in its ability to be used to inhibit viral infection .

HY-114336

Enocyanin 2 Publications Verification	Phosphatase	Inflammation/Immunology
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-N7798

Pennogenin	Reactive Oxygen Species	Inflammation/Immunology
Pennogenin is a bioactive component which can be isolated from T. govanianum rhizomes. Pennogenin exhibits significant in vitro inhibitory effect on release of ROS .

HY-139622

DN-F01	Myosin	Others
DN-F01 has a strong inhibitory calcium-dependent effect on cardiac myofibrillar ATPase activity with an IC₅₀ value of 11 ± 4 nmol/L.

HY-120333

Antibiotic PF 1052	Antibiotic Fungal Bacterial	Infection
Antibiotic PF 1052 is an antibiotic extracted from a natural product library. Antibiotic PF 1052 has an inhibitory effect on murine neutrophil migration .

HY-N8819

Methyl ganoderate H	Others	Others
Methyl ganoderate H is a natural product that can be isolated from Ganoderma lucidum. Methyl ganoderate H has moderate inhibitory effect to NO production .

HY-N3324

Mangostanol (+)-Mangostanol	Phosphodiesterase (PDE)	Others
Mangostanol ((+)-Mangostanol) is a polyoxygenated xanthone mangostanol, which can be isolated from the shell of Garcinia mangostana, and has inhibitory effect on cAMP phosphodiesterase (PDE) .

Cat. No.	Product Name

HY-L117

Calcium Channel Blocker Library

164 compounds

Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

MCE supplies a unique collection of 164 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

HY-L126

Nuclear Receptor Compound Library

787 compounds

Nuclear receptors (NR) are proteins found in cells that sense androgen and thyroid hormones and certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology and pathology, and regulate the expression of various important genes.

Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders and diabetes. 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors.

MCE supplies a unique collection of 787 nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease and diabetes.

HY-L118

Sodium Channel Blocker Library

151 compounds

Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion.

MCE offers a unique collection of 151 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

HY-L132

Chemokine Compound Library

174 compounds

Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system.

The biological effects of chemokines are achieved by binding to chemokine receptors, which are G protein-coupled receptors found on the surface of leukocytes. Some chemokine receptors are involved in directing tumor metastasis and over-expression by certain tumors. So inhibiting the interaction between chemokine and chemokine receptors on the surface of tumor cells may be a new possible therapeutic approach. Some chemokine receptors are coreceptors for HIV entry, and related inhibitors have been approved by the FDA to treat patients with HIV. Obviously, chemokines and chemokine receptors have become new targets for studying cancer, HIV, inflammation, and other diseases.

MCE supplies a unique collection of 174 chemokine or chemokine receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on chemokine or chemokine receptors. MCE Chemokine Library is a useful tool for drug research related to cancer, AIDS, and wound therapy.

HY-L133

Cuproptosis Compound Library

246 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 246 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Type

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Chromogenic Substrates
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-12519G

Oltipraz (GMP) RP 35972 (GMP); NSC 347901 (GMP)	Fluorescent Dye
Oltipraz (GMP) is Oltipraz (HY-12519) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Oltipraz has an inhibitory effect on HIF-1α activation. Oltipraz is a potent Nrf2 activator .

HY-P4202A

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Chromogenic Substrates
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-D2421

DEAE-dex-Cy5	Fluorescent Dyes/Probes
DEAE-dex-Cy5 is a fluorescent labeling reagent that combines Cy5 (HY-D0821) fluorescent dye, Dextran (dex) and Diethylaminoethyl (DEAE). Cy5 is a Cyanine dye (with a long wavelength about 662nm) that can be used for molecular labeling and microscopy imaging. Dex has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander .

HY-D2460

Dextran-CY5.5	Dyes
Dextran-CY5.5 is a CY5.5 (HY-D0924) labeled Dextran (HY-112624) conjugate. CY5.5 is a Cyanine dye (The excitation wavelength is usually 673nm and the emission wavelength is 707nm) that can be used for the labeling of proteins, antibodies and small molecular compounds. Dextran has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander .

HY-D2466

Dextran-CY3

Dyes

Dextran-CY3 is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Dextran (HY-112624). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Dextran has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander .

HY-D2204

SHP1-IN-1	Fluorescent Dyes/Probes
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe ³⁺ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) .

HY-W923645

Fluorescein O,O′-diacrylate

Diacryloyloxyfluorescein

Fluorescent Dyes/Probes

Fluorescein O,O′-diacrylate (Diacryloyloxyfluorescein) is a fluorescent compound with good biocompatibility and cell labeling ability. Fluorescein O,O′-diacrylate is often used in biological imaging and cell tracking research, and can effectively label cells and track their dynamic changes in vivo. Fluorescein O,O′-diacrylate is also used in compound delivery systems to improve the localization accuracy and inhibitory effect of compounds. Fluorescein O,O′-diacrylate is also used to prepare polymer materials to enhance their optical properties and biological interactions.

Cat. No.	Product Name	Type

HY-112624

Dextran Dextran 40	Drug Delivery
Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.

HY-P1956

Human serum albumin

2 Publications Verification

HSA

Native Proteins

Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-P1956A

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)

HSA (Cell culture grade, Endotoxin<0.125 EU/mg)

Native Proteins

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-W342458

Betamethasone 17-Propionate

Cell Assay Reagents

Betamethasone 17-Propionate is a compound used to study its effects on endotoxin-induced uveitis in rats. It has the activity of inhibiting the infiltration of cells into the aqueous humor in endotoxin-induced uveitis by eye drops and systemic administration at a certain dose. However, its inhibitory effect is relatively weak compared with some other compounds. At the same time, the dose for systemic administration is 1mg/kg. In addition, Betamethasone 17-Propionate has a weaker inhibitory effect on the release of IL-8 from rat peritoneal exudate cells in an in vitro interleukin-8 (IL-8) release assay than betamethasone. Moreover, the simultaneous addition of betamethasone dipropionate and betamethasone 17-Propionate reduces the inhibitory effect of betamethasone on cell infiltration and IL-1β gene expression.

HY-12519G

Oltipraz (GMP) RP 35972 (GMP); NSC 347901 (GMP)	Biochemical Assay Reagents
Oltipraz (GMP) is Oltipraz (HY-12519) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Oltipraz has an inhibitory effect on HIF-1α activation. Oltipraz is a potent Nrf2 activator .

HY-N7833

Heneicosapentaenoic acid

Drug Delivery

Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.

Cat. No.	Product Name	Target	Research Area

HY-P1083

Dynamin inhibitory peptide 1 Publications Verification	Dynamin	Neurological Disease
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors .

HY-W009177

S-Methylglutathione	Glyoxalase (GLO)	Others
S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH . S-Methylglutathione has inhibitory effect on glyoxalase 1 .

HY-P10106

TAT-PAK18 inhibitory peptide	PAK	Cancer
TAT-PAK18 inhibitory peptide is a membrane-permeable PAK inhibitory peptide. TAT-PAK18 inhibitory peptide reduces F-actin clusters and occludes the effect of Shank3 knockdown .

HY-P1083A

Dynamin inhibitory peptide TFA	Dynamin	Neurological Disease
Dynamin inhibitory peptide TFA competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide TFA blocks the dopamine D₃ effect on GABA_A receptors .

HY-129422

Diallyl G	Opioid Receptor	Neurological Disease
Diallyl G is a delta-opioid receptor antagonist. Diallyl G shows inhibitory effect on GTPase .

HY-P4810

Polyphemusin II-Derived Peptide T140	CXCR	Infection
Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 .

HY-P10591

Olatorepatide Olatorepatidum	Insulin Receptor GLP Receptor	Metabolic Disease
Olatorepatide (Olatorepatidum) is a dual gastric inhibitory polypeptide (GIP) receptor and glucagon like peptide 1 (GLP-1) receptor agonist, with antidiabetic effect .

HY-P4816

Pseudin-2	Bacterial Fungal	Infection Inflammation/Immunology
Pseudin-2, an AMP thast could be isolated from the skin of the South American paradoxical frog Pseudis paradoxa, exert a potent growth inhibitory effect against Gram-negative bacteria .

HY-P2357

MI-1544	GnRH Receptor	Metabolic Disease
MI-1544 is a powerful GnRH antagonist. MI-1544 induces inhibitory effects on the pituitary LH release and on gonads. MI-1544 can be used for the research of antifertility effect .

HY-P1060

LPYFD-NH2	Amyloid-β	Neurological Disease
LPYFD-NH2, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 can be used for the research of Alzheimer’s disease .

HY-P3979

Defensin HNP 4 HNP 4	Bacterial	Infection
Defensin HNP 4 (HNP 4) is a single 11 amino acid long fragment of HNP-41-11. Defensin HNP 4 has inhibitory effect against multidrug-resistant and non-resistant strains .

HY-P1060A

LPYFD-NH2 TFA	Amyloid-β	Neurological Disease
LPYFD-NH2 TFA, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 TFA can be used for the research of Alzheimer’s disease .

HY-P1149

Epitalon Epithalon; Epithalamin	Telomerase	Neurological Disease Cancer
Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa .

HY-P2088

TANDEM Des-N-tetramethyltriostin A	Antibiotic	Cancer
TANDEM (Des-N-tetramethyltriostin A) is a synthetic antibiotic drug that has the activity of inhibiting the growth of tumor cells. TANDEM can be used in combination with chemotherapy to enhance the inhibitory effect. TANDEM has shown significant inhibitory effects on a variety of cancer cell lines in in vitro experiments. The structure of TANDEM allows it to effectively target tumor cells during the inhibition process. TANDEM's mechanism of action involves interfering with cell proliferation and survival pathways .

HY-N6689

Destruxin A 1 Publications Verification	Insecticide Bacterial	Infection Inflammation/Immunology Cancer
Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections .

HY-P1149A

Epitalon TFA Epithalon TFA; Epithalamin TFA	Telomerase	Neurological Disease Cancer
Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon TFA can be used for cancer, old age and Retinitis Pigmentosa .

HY-P10425

T2857W	Peptides	Cancer
T2857W is a mutant peptide that has inhibitory effect on KIX-MLL interaction (IC₅₀=5.67 μM). T2857W can be used for protein-protein interaction (PPI) and for the study of diseases related to KIX-MLL interaction, such as leukemia, cancer, etc .

HY-P3325

P8RI D-P8RI	VEGFR	Inflammation/Immunology
P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway .

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-P4202A

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-P5801

Phlo1a μ-TrTx-Phlo1a	Sodium Channel	Neurological Disease
Phlo1a (μ-TrTx-Phlo1a) is a peptide toxin contains 35-amino acid residues. Phlo1b is a selective Nav1.7 inhibitor. Phlo1a has a weak inhibitory effect on Nav1.2 and Nav1.5 .

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis .

HY-P5800

Phlo1b μ-TrTx-Phlo1b	Sodium Channel	Neurological Disease
Phlo1b (μ-TrTx-Phlo1b) is a peptide toxin contains 35-amino acid residues. Phlo1b is a selective Nav1.7 inhibitor. Phlo1b has a weak inhibitory effect on Nav1.2 and Nav1.5 .

HY-P3971

H-Leu-Ser-Lys-Leu-OH	TGF-beta/Smad	Inflammation/Immunology
H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on TGF-β1 activation. H-Leu-Ser-Lys-Leu-OH, binding with KRFK (HY-P3970), can block the signal transduction of TGF-β1, and prevent the progression of hepatic damage and fibrosis .

HY-P10847

KS-58	Ras	Cancer
KS-58 is a KRpep-2d (HY-P3277) derivative. KS-58 is a K-Ras (G12D) inhibitory peptide that selectively binds K-Ras. KS-58 can enter cells and block intracellular Ras interaction with effector proteins. KS-58 inhibits the proliferation of tumor cells and has antitumor activity .

Cat. No.	Product Name	Target	Research Area

HY-P99623

Flotetuzumab MGD006; S80880	CD3	Cancer
Flotetuzumab (MGD006; S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML) .

HY-P990031

Dargistotug M-6223	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7962

Cornoside	Phyla nodiflora (L.) E. L. Greene Quinones Classification of Application Fields Verbenaceae Source classification Benzene Quinones Plants Disease Research Fields Inflammation/Immunology	Aldose Reductase
Cornoside is a phenolic glycoside and has inhibitory effect on rat lens aldose reductase (AR) with an IC₅₀ of 150 μM .

HY-107421

Prostratin	Infection Structural Classification Classification of Application Fields Terpenoids Thymelaeaceae Source classification Diterpenoids Plants Disease Research Fields Wikstroemia chamaedaphne Meisn.	PKC HIV
Prostratin, a natural terpenoid compound, is a PKC activator, with a K_i of 12.5 nM and shows inhibitory effect on HIV-1.

HY-N2111

Momordicoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Plants Disease Research Fields Momordica charantia Linn.	Phosphatase
Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on protein tyrosine phosphatase (PTP1B) .

HY-N6069

Raspberry ketone glucoside 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Rosaceae Plants Rubus corchorifolius Linn. f. Disease Research Fields Inflammation/Immunology	Others
Raspberry ketone glucoside is a natural product in raspberry fruit. Raspberry ketone glucosidev has the inhibitory effect on the melanin synthesis .

HY-125112

Vicenin-1	Cardiovascular Disease Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Trigonella foenum-graecum Linn.	Angiotensin-converting Enzyme (ACE)
Vicenin 1 is a C-glycosylflavone that has an inhibitory effect on angiotensin-converting enzyme (ACE)(IC₅₀=52.50 μM) .

HY-N3226

Myricananin A	Source classification Myrica nagi Plants Myricaceae	NO Synthase
Myricananin A is a colorless needle that has inhibitory effect on iNOS .

HY-N11566

(+)-Oxypeucedanin methanolate	Structural Classification Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt.	Prostaglandin Receptor
(+)-Oxypeucedanin methanolate (compound 9) is a natural compound with inhibitory effect on prostaglandin E2 production .

HY-N10024

Ganolactone Ganolactone A	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	EBV
Ganolactone is a triterpenoid compound. Ganolactone has a weak inhibitory effect on EBV early antigen .

HY-N9092

Geranyl ferulate (E)-geranylferulic acid	Zingiber officinale Roscoe Monophenols Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Zingiberaceae	NO Synthase
Geranyl ferulate ((E)-geranylferulic acid), isolated from Zingiber officinale, exhibits inhibitory effect on the production of nitric oxide (NO) .

HY-N3231

Murraol CM-c2	Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants Murraya exotica L. Mant.	Lipoxygenase COX
Murraol (CM-c2), a coumarin, can be isolated from the leaves of Madagascar pine cork (Apiaceae). Murraol has cyclooxygenase (COX) and lipoxygenase inhibitory properties and has an inhibitory effect on the growth of cancer cells .

HY-116885

Thunalbene	Structural Classification Thunia alba (Lindl.) Rchb. F. Orchidaceae Source classification Phenols Plants	NO Synthase
Thunalbene is a stilbene derivative isolated from Thunia alba. Thunalbene has a weak inhibitory effect on nitric oxide production and is not cytotoxic .

HY-142013

Blestriarene B (-)-Blestriarene B	Bletilla striata (Thunb. ex Murray) Rchb. f. Structural Classification Natural Products Orchidaceae Source classification Plants	Microtubule/Tubulin
Blestriarene B ((-)-Blestriarene B) a stilbenoid isolated by the guidance of inhibitory effect of tubulin polymerization from the tubers of Bletilla striata (Orchidaceae) .

HY-N11443

Acetyllycoposerramine M	Lycopodiaceae Structural Classification Alkaloids Source classification Palhinhaea cernua (L.) Vasc. et Franco Plants	Others
Acetyllycoposerramine M is a lycopodine-type alkaloid, which can be isolated from Lycopodium japonicum. But Acetyllycoposerramine M has no inhibitory effect on acetylcholinesterase .

HY-N3788

Dulcioic acid	Triterpenes Structural Classification Terpenoids Source classification Celastraceae Plants Tripterygium wilfordii Hook. f.	Others
Dulcioic acid (compound 19) is a product isolated from Tripterygium wilfordii Hook f. Dulcioic acid shows a significant inhibitory effect on cytokine production .

HY-W596782

Chaetochromin A Chaetochromin	Structural Classification Natural Products Microorganisms Source classification	Others
Chaetochromin A (Compound 1) is a fungal metabolite. Chaetochromin A shows inhibitory effect on botulinum neurotoxin serotype A (BoNT A) (IC₅₀= 24.6 μM) .

HY-114336

Enocyanin 2 Publications Verification	Anthocyans Flavonoids Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Disease Research Fields Inflammation/Immunology	Phosphatase
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-N7798

Pennogenin	Structural Classification Natural Products Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Pennogenin is a bioactive component which can be isolated from T. govanianum rhizomes. Pennogenin exhibits significant in vitro inhibitory effect on release of ROS .

HY-120333

Antibiotic PF 1052	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields Other Antibiotics	Antibiotic Fungal Bacterial
Antibiotic PF 1052 is an antibiotic extracted from a natural product library. Antibiotic PF 1052 has an inhibitory effect on murine neutrophil migration .

HY-N3324

Mangostanol (+)-Mangostanol	Structural Classification Flavonoids Source classification Guttiferae Plants Garcinia hanburyi Hook. f. Other Flavonoids	Phosphodiesterase (PDE)
Mangostanol ((+)-Mangostanol) is a polyoxygenated xanthone mangostanol, which can be isolated from the shell of Garcinia mangostana, and has inhibitory effect on cAMP phosphodiesterase (PDE) .

HY-B1167A

Ajmaline hydrochloride Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride	Rauvolfia verticillata (Lour.) Baill. Apocynaceae Structural Classification Natural Products Source classification Plants	Others
Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.

HY-N10416

Neuroinflammatory-IN-1	Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Disease Research Fields Inflammation/Immunology	Others
Neuroinflammatory-IN-1 (Compound 5) is an anti-neuroinflammatory agent and displays inhibitory effect on nitric oxide (NO) production with an IC₅₀ value of 65.4 μM .

HY-N3654

Cyclo(l-Pro-d-Leu)	Structural Classification Microorganisms Antibiotics Source classification	Tyrosinase
Cyclo(l-Pro-d-Leu) (compound 11) is a collagenase inhibitor that can be extracted from R. atalantica and also exhibits a mild tyrosinase inhibitory effect .

HY-N7040

11-Deoxymogroside IIE	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	HSV
11-Deoxymogroside IIE is a cucurbitane glycoside, isolated from Siraitia grosvenorii fruits. 11-Deoxymogroside IIE has inhibitory effect against Epstein Barr virus (EBV-EA) activation induced by TPA, shows weak inhibitory effect on (+/-)-(E)-methyl1-2-[E-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR1), a NO donor .

HY-B1918

(+)-Bornyl acetate	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Hamamelidaceae Plants Disease Research Fields Liquidambar formosana Hance	Interleukin Related
(+)-Bornyl acetate is found in pichtae essential oil (Siberian fir needle oil). (+)-Bornyl acetate has a stronger inhibitory effect on root growth of Arabidopsis seedlings .

HY-N7692

Polyporusterone A	Classification of Application Fields Source classification Polyporaceae Other Diseases Poria cocos Plants Disease Research Fields Steroids	Others
Polyporusterone A is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone A has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis) .

HY-N10860

5-O-beta-D-Glucopyranosylmyricanol	Structural Classification Other Monoterpenes Terpenoids Morella esculenta (Buch.-Ham. ex D. Don) I. M. Turner Source classification Plants Myricaceae	Angiotensin Receptor
5-O-beta-D-Glucopyranosylmyricanol is a diarylheptane compound isolated from Myrica esculenta that has a weak inhibitory effect on angiotensin-converting enzyme (ACE) .

HY-N1289

Sequosempervirin B	Structural Classification Cupressaceae Source classification Phenols Polyphenols Plants Sequoia sempervirens (D. Don) Endl.	Fungal Phosphodiesterase (PDE)
Sequosempervirin B, a norlignan isolated from the branches and leaves of Sequoia sempervirens, has antifungal properties. Sequosempervirin B has an inhibitory effect on cyclic AMP phosphodiesterase .

HY-N0555

Escin IB	Triterpenes Structural Classification Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Metabolic Disease Plants Disease Research Fields	Lipase
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity .

HY-N2058

Neogambogic acid	Infection Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Disease Research Fields	Bacterial Apoptosis
Neogambogic acid, an active ingredient in garcinia, induces apoptosis and has anticancer effect. Neogambogic acid has significant inhibitory activity toward methicillin-resistant Staphylococcus aureus (MRSA) .

HY-N4114

Picrocrocin	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Lridaceae Plants Crocus sativus L. Disease Research Fields Cancer	Apoptosis
Picrocrocin, an apocarotenoid found in Saffron. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells .

HY-N6621

Hippeastrine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Narcissus tazetta Linn. var. chinensis M.Roemer Source classification Plants Disease Research Fields Amaryllidaceae Cancer	Topoisomerase
Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC₅₀ at 7.25 μg/mL. Antiproliferative and anticancer activities .

HY-N10089

Psiguadial D	Structural Classification Terpenoids Sesquiterpenes Source classification Psidium guajava Linn. Myrtaceae Plants	Others
Psiguadial D is a terpenoid that can be isolated from Psidium guajava, and it has a strong inhibitory effect on the growth of HepG2 cells, with an IC₅₀value of 128.3 nM .

HY-N3102

p-Coumaryl alcohol p-Hydroxycinnamyl alcohol	Structural Classification Simple Phenylpropanols Source classification Alpinia officinarum Hance Phenylpropanoids Plants Zingiberaceae	Others
p-Coumaryl alcohol is an antioxidant that can be isolated from Alpinia officinarum Hance. p-Coumaryl alcohol has inhibitory effect during the autoxidation of methyl linoleate .

HY-N12737

15-epi-Danshenol A	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants	Others
15-epi-Danshenol A is a diterpenoid with an immune-modulating activity. 15-epi-Danshenol A shows inhibitory effect on B lymphoblasts cells in a concentration-dependent manner .

HY-N7272

Cirsimarin	Flavonoids Monophenols Classification of Application Fields Flavones Leguminosae Source classification Phenols Metabolic Disease Abrus precatorius Linn. Plants Disease Research Fields	Phosphodiesterase (PDE)
Cirsimarin is a potent antilipogenic flavonoid isolated from Microtea debilis. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on adenosin A1 receptor and its inhibitory effect on phosphodiesterase .

HY-N0539

Calceolarioside B	Structural Classification Classification of Application Fields Simple Phenylpropanols Akebia quinata (Houttuyn) Decaisne Lardizabalaceae Source classification Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Aldose Reductase
Calceolarioside B is a natural product isolated from Akebia quinata leaves. Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC₅₀ of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC₅₀ of 94.60 μM .

HY-N12134

Methyl piperate	Piper longum Linn. Structural Classification Natural Products Source classification Piperaceae Plants	Monoamine Oxidase
Methylpiperic acid is a piperine alkaloid with significant MAO inhibitory activity (IC₅₀3.6 μM). Methylpiperic acid is less effective against MAO-B (IC₅₀1.6 μM) than MAO-A (IC₅₀27.1 μM) has a bidirectional inhibitory effect. Methylphenidate is used to treat mental disorders .

HY-N2429

Sphondin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Plants Seriphidium transiliense Inflammation/Immunology Disease Research Fields	COX
Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE₂ release in A549 cells .

HY-N7693

Polyporusterone B	Classification of Application Fields Source classification Polyporaceae Other Diseases Poria cocos Plants Disease Research Fields Steroids	Others
Polyporusterone B is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone B has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis) .

HY-N0545

Taurocholic acid sodium 15+ Cited Publications Sodium taurocholate; N-Choloyltaurine sodium	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	VEGFR Endogenous Metabolite
Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect .

HY-B1788

Taurocholic acid 15+ Cited Publications Taurocholic Acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect .

HY-N4265

Vinaginsenoside R4	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology Araliaceae	Others
Vinaginsenoside R4, isolated from the leaves of hydroponic Panax ginseng. It has an inhibitory effect on melanin biosynthesis without any cytotoxic effects on the melan-a cells, and enhances the depigmentation on the zebrafish .

HY-N4095

Brevifolincarboxylic acid	Structural Classification Natural Products Classification of Application Fields Polygonaceae Source classification Metabolic Disease Plants other families Phenols Polyphenols Polygonum capitatum Buch.-Ham. ex D. Don Prodr Inflammation/Immunology Disease Research Fields	Aryl Hydrocarbon Receptor Glycosidase
Brevifolincarboxylic acid is extracted from Polygonum capitatum , has inhibitory effect on the aryl hydrocarbon receptor (AhR) . Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC₅₀ of 323.46 μM .

HY-N7825

Gomisin L1	Triterpenes Structural Classification Terpenoids Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Others
Gomisin L1 is a lignan, shows inhibitory effect on cell viability of A2780 and Ishikawa cells, with IC₅₀s of 39.06 μM and 74.16 μM, respectively .

HY-N13114

8-Gingerdione	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	Others
8-Gingerdione can be isolated from ginger (Zingiber officinale). 8-Gingerdione has no significant inhibitory effect on the production of inflammatory factors NO, TNF-α, and IL-6.

HY-N2483

Hydroprotopine	Alkaloids Classification of Application Fields Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Others
Hydroprotopine is a alkaloid from Hypecoum leptocarpumand. Leptopidine can suppress growth and induce cytotoxicity in breast cancer cells and that the cytotoxicity of leptopidine may be related to its inhibitory effect on fatty acid synthase expression .

HY-N2495

Isomucronulatol	Structural Classification Classification of Application Fields Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Flavonoids other families Leguminosae Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Others
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N12210

Notrilobolide	Structural Classification Natural Products Source classification Plants Umbelliferae Glechoma hederacea L.	Parasite
Notrilobolide is an alkaloid with insecticidal properties isolated from sweet potatoes. Notrilobolide has an inhibitory effect on the larval development of pests such as Tribolium Castaneum, affecting the digestion and reproduction of insects by inhibiting the fecundity of pests .

HY-W748013

Cervinomycin A2	Structural Classification Antibiotics Other Antibiotics	Antibiotic Bacterial
Cervinomycin A2 is an anti-anaerobic antibiotic that can be isolated from Streptomyces cervicalis. Cervinomycin A2 has a strong inhibitory effect on Clostridium perfringens, Gastrococcus prophylacticus, and Bacteroides fragilis .

HY-N13134

Kadsutherin F	Structural Classification Kadsura heteroclita (Roxb.) Craib Source classification Lignans Phenylpropanoids Plants Schisandraceae	Others
Kadsutherin F (compound 2) is a lignin that can be isolated from Kadsura. Kadsutherin F has an inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation with an inhibition rate of 49.47% .

Cat. No.	Product Name	Chemical Structure

HY-B0673S

Pirfenidone-d5
Pirfenidone-d₅ is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].

HY-160144S

Lomedeucitinib
Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor. Lomedeucitinib has anti-inflammatory activity and significant inhibitory effect on IFNα (IC₅₀=0.047 μM) production downstream of IL-12/TYK2. Lomedeucitinib is indicated for the study of plaque psoriasis and pruritus .

HY-19312S

3-Methyladenine-d3
3-Methyladenine-d₃ is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].

HY-136406S

Bongkrekic acid-13C28

Bongkrekic acid- ¹³C₂₈ is the ¹³C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .

HY-160144S2

(rac)-Lomedeucitinib
(rac)-Lomedeucitinib ((rac)-BMS-986322) is the racemate of Lomedeucitinib. Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor. Lomedeucitinib has anti-inflammatory activity and significant inhibitory effect on IFNα (IC50=0.047 μM) production downstream of IL-12/TYK2. Lomedeucitinib is indicated for the study of plaque psoriasis and pruritus .

HY-Y0790S

Cuminaldehyde-d8
Cuminaldehyde-d8 is deuterated labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

HY-W653842

Taurocholic acid-d8 sodium
Taurocholic acid-d₈ (sodium) is deuterium labeled Taurocholic acid (sodium). Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect .

HY-W653893

Taurocholic acid-d5 sodium
Taurocholic acid-d₅ (sodium) is deuterium labeled Taurocholic acid (sodium). Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect .

HY-W015307S

4-Ethyloctanoic acid-13C2
4-Ethyloctanoic acid- ¹³C₂ is ¹³C labeled Cuminaldehyde (HY-Y0790). Cuminaldehyde is the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity .

HY-12519S

Oltipraz-d3
Oltipraz-d₃ is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.

HY-23155S

2-Phenylethyl isothiocyanate-d5

2-Phenylethyl isothiocyanate-d₅ isothiocyanate-d₅ is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].

HY-W700241

Norharman-d7

Norharman-d₇ is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-N7844S

N6-Benzyladenosine-d5
N6-Benzyladenosine-d₅ (Benzyladenosine-d₅) is deuterium labeled N6-Benzyladenosine. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

Cat. No.	Product Name		Classification

HY-159562

COX-2-IN-46		Azide
COX-2-IN-46 (compound 5m) is an anti-inflammatory agent with potent analgesic activity. COX-2-IN-46 exhibits a significant inhibitory effect on COX-2 (IC₅₀=87.74 nM) .

HY-159561

COX-1-IN-2		Azide
COX-1-IN-2 (compound 5h) is an anti-inflammatory agent with potent analgesic activity. COX-1-IN-2 exhibits a significant inhibitory effect on COX-1 (IC₅₀=38.76 nM) .

HY-162356

PD-L1-IN-4		Azide
PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC₅₀ = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC₅₀ = 152.8 nM). PD-L1-IN-4 can be used for the research of cancer .

HY-W130901

5-Phenyl-1-pentyne Pent-4-ynylbenzene		Alkynes
5-Phenyl-1-pentyne (Pent-4-ynylbenzene) is a compound with antibacterial and antitumor activity, which can effectively inhibit the growth of certain cancer cells. 5-Phenyl-1-pentyne is often used as a reaction intermediate in organic synthesis to promote a variety of chemical reactions. 5-Phenyl-1-pentyne is also used in the synthesis of new compounds to improve the bioavailability and inhibitory effect of the compounds.

HY-172140

Ebio3		Alkynes
Ebio3 is a selective potassium channel (KCNQ2) inhibitor with an IC₅₀ of 1.2 nM. Ebio3 binds to the KCNQ2 channel through its hydrophobic tail, causing the S6 helix to move inward, which leads to the closure of the inner gate. The inhibitory effect of Ebio3 is also effective in pathogenic mutants of KCNQ2 (such as R75C and I238L), where it can inhibit outward currents by more than 80%. Ebio3 is expected to be used in the research of neurological diseases such as epilepsy .

Cat. No.	Product Name		Classification

HY-112624

Dextran Dextran 40		Fillers
Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.

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