1. Gene
  2. Ar - androgen receptor Gene

Ar - androgen receptor Gene

Mus musculus

Also known as Tfm

Gene ID: 11835 | Gene type: protein coding

About Ar

Chromosome X: 97,192,375-97,366,821 forward strand.GRCm39:CM001013.3

This gene has 1 transcript (splice variant), 277 orthologues, 8 paralogues and is associated with 89 phenotypes. Biased expression in adrenal adult (RPKM 4.7), genital fat pad adult (RPKM 4.4) and 12 other tissues.

Summary

This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid Hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male Animals. Loss of function in female Animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]

Ar Products(1)

mRNA Protein Name
NM_013476.4 NP_038504.1 androgen receptor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12145204 MGI
enables POU domain binding IDA
IDA: Inferred from direct assay
11997177 MGI
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
27959439 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
17277772 MGI
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
12145204 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11997177 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8119157 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Leydig cell differentiation IMP
IMP: Inferred from mutant phenotype
19574395 MGI
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
14676301 MGI
acts upstream of or within androgen receptor signaling pathway IDA
IDA: Inferred from direct assay
15199138 MGI
involved in androgen receptor signaling pathway IDA
IDA: Inferred from direct assay
18761815 MGI
acts upstream of or within animal organ formation IMP
IMP: Inferred from mutant phenotype
17317769 MGI
involved in cellular response to testosterone stimulus IDA
IDA: Inferred from direct assay
18761815 MGI
acts upstream of or within epithelial cell differentiation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
17652515 MGI
acts upstream of or within epithelial cell morphogenesis IGI
IGI: Inferred from genetic interaction
21084446 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17652515 MGI
acts upstream of estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14676301 MGI
acts upstream of or within fertilization IMP
IMP: Inferred from mutant phenotype
19574395 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
27959439 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10319319 MGI
acts upstream of insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14676301 MGI
acts upstream of or within lateral sprouting involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
14676301 MGI
acts upstream of or within male genitalia morphogenesis IMP
IMP: Inferred from mutant phenotype
19282366 MGI
acts upstream of or within male gonad development IGI
IGI: Inferred from genetic interaction
21084446 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
10319319 MGI
acts upstream of or within male somatic sex determination IMP
IMP: Inferred from mutant phenotype
5452809 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
14676301 MGI
acts upstream of or within morphogenesis of an epithelial fold IMP
IMP: Inferred from mutant phenotype
17652515 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
19574395 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17652515 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
14676301 MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in prostate gland development IDA
IDA: Inferred from direct assay
11535819 MGI
acts upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14676301 MGI
acts upstream of or within positive regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14676301 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16254014 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16254014 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17332066 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: Inferred from mutant phenotype
17652515 MGI
acts upstream of or within prostate gland growth IMP
IMP: Inferred from mutant phenotype
17317769 MGI
acts upstream of or within prostate induction IMP
IMP: Inferred from mutant phenotype
17317769 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12145204 MGI
acts upstream of or within regulation of developmental growth IMP
IMP: Inferred from mutant phenotype
17317769 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17332066 MGI
acts upstream of or within regulation of prostatic bud formation IGI
IGI: Inferred from genetic interaction
12941620 MGI
acts upstream of or within regulation of systemic arterial blood pressure IGI
IGI: Inferred from genetic interaction
18468998 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17332066 MGI
acts upstream of or within reproductive structure development IMP
IMP: Inferred from mutant phenotype
17317769 MGI
acts upstream of or within reproductive system development IGI
IGI: Inferred from genetic interaction
19574395 MGI
acts upstream of or within seminiferous tubule development IGI
IGI: Inferred from genetic interaction
21084446 MGI
acts upstream of or within seminiferous tubule development IMP
IMP: Inferred from mutant phenotype
19574395 MGI
acts upstream of or within single fertilization IGI
IGI: Inferred from genetic interaction
21084446 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
18403489 MGI
acts upstream of or within tertiary branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
14676301 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21427128 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21427128 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12145204 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11105903 MGI
located in nucleus IPI
IPI: Inferred from physical interaction
14576337 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18468998 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ar Protein Structure

Androgen_recep

Androgen_recep: cl27454 (5 - 439)

NR_DBD_AR

NR_DBD_AR: cd07173 (533 - 614)

NR_LBD_AR

NR_LBD_AR: cd07073 (651 - 896)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 899 a.a.
Protein Preferred Names Protein Names

androgen receptor

dihydrotestosterone receptor

nuclear receptor subfamily 3 group C member 4

testicular feminization

Ar Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Ar P19091 Casp8 Mus musculus O89110 17170703
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Ar NCBI NCBI:367
Canis familiaris Ar NCBI NCBI:403588
Macaca fascicularis Ar NCBI NCBI:102117720
Canis lupus familiaris Ar NCBI
Susscrofa domestica Ar NCBI
Leporidae Ar NCBI
Rattus norvegicus Ar NCBI NCBI:24208
Macaca mulatta Ar NCBI NCBI:574293