Search Result
Results for "
ASIC1,neutral pH
" in MedChemExpress (MCE) Product Catalog:
123
Biochemical Assay Reagents
13
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B1610N
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.1M, pH 4.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.1M, pH 4.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.1M, pH 4.0 is the preferred solution for most antibodies [1]. Sodium citrate buffer, 0.1M, pH 4.0 is used in the hydration of liposome film .
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- HY-B1610J
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 5.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 5.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 5.0 is the preferred solution for most antibodies [1]. Sodium citrate buffer, 0.5M, pH 5.0 is used as solution for captisol in animal tumor models .
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- HY-144121
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Bacterial
Fungal
Apoptosis
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Infection
Cancer
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Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities [1].
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- HY-B1610K
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. [1].
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- HY-B1610M
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies [1].
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- HY-B1610L
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue [1].
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- HY-B0246S3
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- HY-133463
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-133465
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-151797
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CaMK
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Neurological Disease
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Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders [1].
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- HY-112798
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Apolipoprotein
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Neurological Disease
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PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
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- HY-141808
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Others
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Cancer
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AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis [1].
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- HY-10499
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- HY-149669
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PI3K
HDAC
Apoptosis
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Cancer
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PH14 is a dual PI3K/HDAC inhibitor with IC50 values of 20.3 nM and 24.5 nM for PI3Kα and HDAC3, respectively. PH14 has antiproliferative activity and also induces apoptosis in Jeko-1 cells. PH14 can be used in cancer research, such as lymphoma [1].
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- HY-140349
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PROTAC Linkers
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Cancer
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AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1]. AZD-CO-C2-Ph-amido-Ph-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-124480
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D1094
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SNARF 1
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Fluorescent Dye
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Others
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Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH. Carboxy-SNARF 1 (5/6-mixture) can be used for measurement pH [1].
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- HY-10499A
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BIM-46187 tetrahydrochloride
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Others
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Neurological Disease
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PH-064 tetrahydrochloride is an inhibitor of heterotrimeric G-protein complex.
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- HY-10403A
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p38 MAPK
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Inflammation/Immunology
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(aS)-PH-797804 is a selective p38 MAPK inhibitor with IC50 values for p38 α /β of 26 nM and 102 nM, respectively. (aS)-PH-797804 has anti-inflammatory activity [1] .
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- HY-10403
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- HY-141894
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Histone Acetyltransferase
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Metabolic Disease
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5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation [1] .
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- HY-D1093
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Fluorescent Dye
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Others
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Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe that is sensitive to pH. Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) can be used for measurement of intracellular pH [1].
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- HY-130107
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ADC Linker
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Cancer
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Ald-Ph-NHS ester is a nonclaevable linker for antibody-agent-conjugation (ADC).
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- HY-126908
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130283
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PROTAC Linkers
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Cancer
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Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130928
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ADC Linker
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Cancer
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Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D1457
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Fluorescent Dye
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Others
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DND-189, a low-pH fluorescent probe, is sensitive to neutral and low pH range. DND-189 can be used to measure the pH of acidic organelles [1] .
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- HY-D0265
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Fluorescent Dye
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Others
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Thymolphthalein is an electrochemically active dye due to the presence of thymol fragments. Thymolphthalein is a Phthalein dye used as an acid-base indicator. It is colourless in acid pH and is blue in basic pH [1].
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- HY-116497
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Others
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Cancer
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PH11 is a novel focal adhesion kinase (FAK) inhibitor that rapidly induces apoptosis in TRAIL-resistant PANC-1 cells when combined with TRAIL, but has no effect on normal human fibroblasts. The study found that PH11 downregulates c-FLIP through inhibition of FAK and phosphatidylinositol-3-kinase (PI3K)/AKT pathways, thereby restoring the TRAIL apoptotic pathway, suggesting that this combination therapy may provide an attractive therapeutic strategy for the safe and effective treatment of pancreatic cancer. PH11 selectively inhibits c-FLIP expression by modulating upstream signaling pathways and may represent an innovative therapeutic strategy. Although further work is needed to fully elucidate the mechanism of PH11-induced TRAIL sensitization, we believe that our results will provide a new approach to target c-FLIP without the risk of interfering with caspase-8 processing, which could potentially lead to TRAIL resistance. This study also suggests a role for the FAK/AKT signaling pathway in regulating c-FLIP expression in TRAIL-induced apoptosis, and this understanding will provide important clues to control the resistance mechanism to optimize the potential of TRAIL-based pancreatic cancer treatment.
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- HY-W096158
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PROTAC Linkers
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Cancer
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Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-147118
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ADC Linker
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Cancer
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NHS-SS-Ph is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
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- HY-153395
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Drug-Linker Conjugates for ADC
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Cancer
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PH-HG-005-5 (compound 16c) is a derivative of SN-38 (HY-13704) and can be used as Drug-Linker Conjugates for ADC. PH-HG-005-5 can conjugate to targeting peptides for ADCs synthesis [1].
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- HY-D0252
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Fluorescent Dye
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Others
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m-Cresol purple is a pH indicator dye with large cross section and halochromic property in neutral pH range [1].
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- HY-134653
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Epigenetic Reader Domain
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Cancer
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5-Ph-IAA is a derivative of IAA. 5-Ph-IAA, a ligand, establishes the auxin-inducible degron 2 (AID2) system together with an OsTIR1 (F74G) mutant. AID2 induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, causing tumor suppression [1].
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- HY-133504
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ADC Linker
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Cancer
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Tetrazine-Ph-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetrazine-Ph-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-Y0699
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Fluorescent Dye
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Others
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Methyl red is an azo dye that acts as a pH indicator. Methyl red is red and yellow at pH 4.4 and 6.0 respectively [1].
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- HY-130496
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-163146
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Fluorescent Dye
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Cancer
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TME-HYM (PH Probe) is a novel fluorescent probe based on acidic tumor microenvironment (TME) activation and organic anion transporting polypeptide (OATPs, overexpressed on cancer cells), and can be selective uptaken. TME-HYM (PH Probe) can selectively lit up cancer cells and tumor tissues, offering dual tumor selectivity for precise visualization of tumor mass [1].
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- HY-D0219A
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Fluorescent Dye
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Others
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Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 [1].
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- HY-159575
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PROTAC Linkers
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Cancer
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COOEt-cyclohexane-C-Ph-pyrimidine-diazabicyclo is a PROTAC linker. COOEt-cyclohexane-C-Ph-pyrimidine-diazabicyclo can be used in the synthesis of PROTAC SMARCA2/4-degrader-5 (HY-159456) [1].
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- HY-168203
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-piperidine-O-Ph-NH2 is the conjugate of E3 ligase and linker. Thalidomide-piperidine-O-Ph-NH2 can be used for synthesis of PROTAC degrader MJP6412 (HY-168201) [1].
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- HY-130099
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ADC Linker
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Cancer
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Ald-Ph-amido-PEG2 is a noncleavable ADC linker for antibody-drug conjugate [1].
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- HY-160113
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Biochemical Assay Reagents
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Others
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Sodium phosphate buffer (pH 6.9 0.02 mol/l) is a water-based salt solution. Sodium phosphate buffer (pH 6.9 0.02 mol/l) can be used in a variety of biochemical studies.
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- HY-D0219
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ThymolsulpHonepHthalein
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Fluorescent Dye
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Others
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Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 [1]. Storage: protect from light.
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- HY-130846
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PROTAC Linkers
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Cancer
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Pip-alkyne-Ph-COOCH3 is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC ARD-266 [1]. Pip-alkyne-Ph-COOCH3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-130551
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-W579346
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Biochemical Assay Reagents
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Others
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POPSO sesquisodium is a water-soluble zwitterionic buffer. POPSO sesquisodium is commonly used in biological and biochemical studies to maintain the acidity or alkalinity (pH value) of solutions, especially within the physiological pH range of 7.0 to 8.5 [1].
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- HY-169365
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PD-1/PD-L1
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Others
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2-Methylbiphenyl-oxadiazole-NH-Ph-CHO is the PD-L1 ligand part of AUTAC PD-L1 degrader-3 (HY-169363). 2-Methylbiphenyl-oxadiazole-NH-Ph-CHO can be utilized in AUTAC synthesis [1].
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- HY-126524
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ADC Linker
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Cancer
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N3-Ph-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-Ph-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-168217
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-piperazine-piperidine-2-F-Ph-CHO is a E3 ligase ligand-linker conjugate, which is consisted of a Thalidomide (HY-14658) and a linker Boc-Piperazine-piperidine-2-F-Ph-CHO (HY-168218). Thalidomide-piperazine-piperidine-2-F-Ph-CHO is utilized for synthesis of PROTAC molecule YDR1 (HY-168215) [1].
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- HY-Y0699R
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Fluorescent Dye
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Others
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Methyl red (Standard) is the analytical standard of Methyl red. This product is intended for research and analytical applications. Methyl red is an azo dye that acts as a pH indicator. Methyl red is red and yellow at pH 4.4 and 6.0 respectively [1].
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- HY-140628
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-140629
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-140626
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-140624
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG12-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-140625
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG24-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-140623
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-140627
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-140622
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PROTAC Linkers
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Cancer
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Ald-Ph-amido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
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- HY-133044
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PROTAC Linkers
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Cancer
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Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM [1]. Boc-Pip-alkyne-Ph-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-145567
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pH94B
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Others
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Neurological Disease
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Fasedienol (PH94B) is a neurochemical stimulator of the vomeronasal organ (VON). Fasedienol modulates the olfactory amygdala circuitry of fear and anxiety to alleviate symptoms of PMS and anxiety [1] .
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- HY-161500
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-NHCH2-Ph-pyrimidine-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and a Linker Boc-NHCH2-Ph-pyrimidine-NH2 (HY-161499). Thalidomide-NHCH2-Ph-pyrimidine-NH2 is utilized for synthesis of PROTAC molecule XYD198 (HY-161498) [1].
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- HY-163960
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PROTAC Linkers
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Cancer
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NH2-Ph-NH-cyclohexane-NH-Boc is a PROTAC linker. NH2-Ph-NH-cyclohexane-NH-Boc can be used in synthesis PROTAC erf3a Degrader-1 (HY-163938) [1].
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- HY-163961A
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-NH-cyclohexane-NH-Ph-NH2 is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-NH-cyclohexane-NH-Ph-NH2 can be used to synthesize PROTAC erf3a Degrader-2 (HY-163938A) [1].
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- HY-133464
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-160114
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- HY-133460
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-133479
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-W422359A
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Biochemical Assay Reagents
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Others
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2-Aminopurine-O-Ph-NHCO-C3-COOH hydrochloride is the acid form in the previous step of the final product 2-Aminopurine-O-Ph-NHCO-C3-NHS ester (HY-143336) [1].
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- HY-130638
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VH032-O-pH-PEG1-NH-Boc
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is a synthesized E3 ligase ligand-linker conjugate which is used for the EED-targeted PROTAC [1].
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- HY-149680
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- HY-126533
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ADC Linker
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Cancer
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PDP-C1-Ph-Val-Cit is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
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- HY-D1677
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Fluorescent Dye
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Others
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5(6)-Carboxynaphthofluorescein is a pH-dependent fluorophore. 5(6)-Carboxynaphthofluorescein shows good sensitivity in an alkaline pH range and it can be exploited in the construction of fiber-optic pH sensors. 5(6)-Carboxynaphthofluorescein can be used as a fluorescent pH indicator (Ex/Em=593/668 nm) [1].
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- HY-130096
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ADC Linker
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Cancer
|
|
Ald-Ph-amido-C2-nitrate (Example XXIVb) is a thiazolidine derivative, used as a noncleavable ADC linker [1].
|
-
- HY-130527
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-Ph-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-140636
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-Ph-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-D0870
-
-
- HY-D0870A
-
-
- HY-154801
-
|
|
Others
|
Others
|
|
Biotin-PEG3-CONH-Ph-CF3-diazirine is a biotin labeled PEG3 derivative. Biotin-PEG3-CONH-Ph-CF3-diazirine can be used for protein labeling [1].
|
-
- HY-W011271
-
|
1,4-Piperazinediethanesulfonic acid monosodium
|
Biochemical Assay Reagents
|
Others
|
|
PIPES (1,4-Piperazinediethanesulfonic acid) monosodium is a pH buffer that can be mixed with another disodium salt form of PIPES. By changing the ratio and total amount of the PIPES monosodium and disodium buffers, the pH and ionic strength of the medium can be changed [1].
|
-
- HY-156897
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
Val-Cit-amide-Ph-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocyte growth factor receptor c-Met (MET) or antibody-drug conjugates (ADCs) [1].
|
-
- HY-D0276
-
|
Metacresol purple sodium
|
Biochemical Assay Reagents
|
Others
|
|
m-Cresol purple sodium (Metacresol purple sodium) is a pH indicator. m-Cresol purple sodium solution from yellow to blue in the pH range from 7.5 to 9.0 [1].
|
-
- HY-W342700
-
|
|
Biochemical Assay Reagents
|
Others
|
|
PIPPS is a kind of buffer commonly used in biological and biochemical research to maintain the acidity and alkalinity (pH value) of solutions [1].
|
-
- HY-130816
-
|
VH032-O-pH-PEG1-NH2
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02 [1].
|
-
- HY-163826
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand for E3 ubiquitin ligase. Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph can be connected to the ligand for protein by a linker to form 22-SLF (HY-163807) [1].
|
-
- HY-133545
-
|
|
ADC Linker
|
Cancer
|
|
Mal-Ph-CONH-PEG4- NHS ester is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
|
-
- HY-168223
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-Piperazine-2-F-Ph-CHO (Compound 2) is a PROTAC linker, used for the synthesis of YD54 (HY-168221) [1].
|
-
- HY-130098
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG3-C-COOH is a noncleavable linker used for the antibody-drug conjugate (ADC).
|
-
- HY-133461
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133462
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-Y0317IR
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP (Standard) is the analytical standard of Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP. This product is intended for research and analytical applications. Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-Y1968A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sterile 10 mM Histidine, pH 5.5 buffer is a multi-purpose buffer solution with important applications in many fields such as protein purification, vaccine preparation, drug development, cell culture and electrophoresis. Histidine is an amino acid with good buffering capacity. Sterile 10 mM Histidine, pH 5.5 buffer The sterility and specific pH conditions make it ideal for experiments that require precise control of environmental conditions. The histidine in Sterile 10 mM Histidine, pH 5.5 buffer derivatizes photosensitizers that accumulate and increase greatly upon exposure to light. Histidine-derived photosensitizers are also the primary mediators of tryptophan photooxidation [1].
|
-
- HY-130962
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG23-OPSS is a cleavable 23 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
|
-
- HY-Y0332L
-
|
Potassium pHospHate monobASIC, meets analytical specification of pH. Eur., NF, E340
|
Biochemical Assay Reagents
|
Others
|
|
Potassium dihydrogen phosphate (Potassium phosphate monobasic), meets analytical specification of Ph. Eur., NF, E340 is used as a buffer capacity reagent in molecular biology, biochemistry, and chromatography. For the preparation of biological buffers. It is also used to purify antibodies, and in combination with other sodium phosphates, meets analytical specification of Ph. Eur., NF, E340 [1].
|
-
- HY-130682
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312) [1]. Lenalidomide-propargyl-C2-amido-Ph-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-D0859A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
MOPS sodium salt is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media [1] .
|
-
- HY-133579
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG3-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
|
-
- HY-130097
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG4-C2-acid is a noncleavable linker used for the antibody-drug conjugate (ADC).
|
-
- HY-138519
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-(Mal-PEG3)-PH-N-succinimidyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-W094708D
-
|
Disodium hydrogen pHospHate dihydrate, meets analytical specification of pH. Eur. BP
|
Biochemical Assay Reagents
|
Others
|
|
Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP is an inorganic salt that can be used for life science related research [1].
|
-
- HY-168239
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph is an E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates). Thalidomide-piperidine-CO-piperazine-C-3-Br-Ph can be used for the synthesis of PROTAC SMARCA2 degrader-28 (HY-168236) [1].
|
-
- HY-134705
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG2-amido-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-W096113
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-161496
-
-
- HY-161499
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-NHCH2-Ph-pyrimidine-NH2 is the linker for PROTAC molecule XYD198 (HY-161498) [1].
|
-
- HY-130508
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-130154
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-Ph-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-141115
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-NO2-Ph-PEG12-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-168218
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-Piperazine-piperidine-2-F-Ph-CHO is a PROTAC linker that can be used in the synthesis of YDR1 (HY-168215) [1].
|
-
- HY-D1563
-
|
|
Fluorescent Dye
|
Others
|
|
CypHer 5 is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. CypHer 5 has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. CypHer 5 has been used as a pH sensor of lysosomal compartments [1].
|
-
- HY-Y0317I
-
|
Disodium sulfate, meets analytical specification of pH. Eur. BP USP
|
Biochemical Assay Reagents
|
Others
|
|
Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-133572
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG11-NH-Boc is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
|
-
- HY-101850
-
|
|
Biochemical Assay Reagents
|
Others
|
|
MOPSO is a biological zwitterionic buffer with the useful pH range from 6.2 to 7.6. MOPSO has been employed as a buffer component of charcoal yeast extract medium [1].
|
-
- HY-130100
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG3-C1-Boc is an ADC linker, which belongs to a polyethylene glycol (PEG) linker.
|
-
- HY-130967
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-PEG4-bis-PEG4-propargyl is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Ald-Ph-PEG4-bis-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130102
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG3-C2-Pfp ester is an noncleavable ADC linker, which belongs to a polyethylene glycol (PEG) linker.
|
-
- HY-130202
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-Ph-amido-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-140632
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-Ph-amido-C2-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-Y0344I
-
|
Halite, meets analytical specification of pH. Eur. BP USP
|
Biochemical Assay Reagents
|
Others
Cancer
|
|
Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-130974
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D0169A
-
|
pHenolsulfonepHthalein sodium salt
|
Fluorescent Dye
|
Others
|
|
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction [1] .
|
-
- HY-130105
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG1-C2-Pfp ester is a nonclaevable 1-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-130106
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG1-C2-NHS ester is a nonclaevable 1-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-130101
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG4-C2-NHS ester is a nonclaevable 4-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-130103
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG2-C2-Pfp ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-130104
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-W096118
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG2-O-Ph-3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-D0015A
-
|
|
Fluorescent Dye
|
Others
|
|
Cresol Red sodium is a triarylmethane dye. Cresol Red sodium can be used for indicating pH, temperatures and salinities [1].
|
-
- HY-128369
-
|
Metanil Yellow
|
Cytochrome P450
|
Others
|
|
Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes [1] .
|
-
- HY-131086
-
-
- HY-122457
-
|
|
Antibiotic
|
Infection
|
|
Δ2,3-Doramectin is the primary pH degradation products of doramectin (HY-17035). Doramectin is a antiparasitic antibiotic [1].
|
-
- HY-Y0319B3
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Potassium acetate meets analytical specification of Ph. Eur. BP E261, and can be used as food additives, medicine and cosmetics raw materials [1].
|
-
- HY-168349
-
-
- HY-W087913
-
|
|
Biochemical Assay Reagents
|
Others
|
|
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages [1].
|
-
- HY-130637
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC Linker which is used for the EED-targeted PROTAC [1].
|
-
- HY-B1571
-
|
|
Fluorescent Dye
|
Others
|
|
Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6. Bromophenol blue is used as a sensor for the determination of several compounds including ammonia, drugs, proteins and amino acids. The binding of Bromophenol blue to proteins is accompanied by the appearance of a strong absorbance at 610 nm [1] .
|
-
- HY-130667
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Ald-Ph-amido-C2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130669
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-Ph-amido-C2-PEG3-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-168224
-
|
|
PROTACs
|
Cancer
|
|
Thalidomide-PEG1-piperazine-2-F-Ph-CHO is an E3 ligase ligand-linker conjugate, used for the synthesis of YD54 (HY-168221) [1].
|
-
- HY-125907
-
|
PROTAC Linker 34
|
PROTAC Linkers
|
Cancer
|
|
Dox-Ph-PEG1-Cl (PROTAC Linker 34) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs [1].
|
-
- HY-148608
-
-
- HY-130174
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-Y0317E
-
|
Disodium sulfate (pHarmaceutical primary standard, USP)
|
Biochemical Assay Reagents
|
Others
|
|
Sodium sulfate anhydrous (Disodium sulfate), can be widely used as a desiccant, pH regulator, etc. in biochemical experiments. It is a reference standard grade of the United States Pharmacopeia (USP), pharmaceutical primary standard.
|
-
- HY-158348
-
-
- HY-D1687
-
|
|
Fluorescent Dye
|
Others
|
|
Flubi-2 is a fluorescein-biotin based pH-ratio dye (Ex=480 nm, Em= 520-560 nm) with a pK value of 6.7. Flubi-2 is a hydrolysis product of Flubida-2 (non-fluorescent, membrane permeable). Flubi-2 can be used for pH determination of organelles of the secretory pathway (such as golgi apparatus and endoplasmic reticulum) in living cells [1] .
|
-
- HY-W009245
-
|
|
HIV
|
Infection
Cancer
|
|
Bz-RS-iSer(3-Ph)-OMe (compound 2), a Taxol derivative, inhibits HSV replication cycle at low cytotoxicity, blocks mitotic divisions of Vero cells, influences M-MSV induced tumor size and affects immune response by inhibiting PHA-induced T lymphocyte proliferation [1].
|
-
- HY-D0140
-
|
ETH 5294
|
Fluorescent Dye
|
Others
|
|
Chromoionophore I (ETH 5294) is a hydrophobic pH indicator. Chromoionophore I is used as a transmissive or fluorescent probe molecule in many types of hydrophobic sensor membranes. Chromoionophore I is oil-soluble [1].
|
-
- HY-158118
-
|
|
DNA-PK
|
Cancer
|
|
Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) [1] .
|
-
- HY-Y1977
-
-
- HY-168304
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the E3 ubiquitin ligase ligand and linker of PROTAC (R)-NX-2127 (HY-153220A), which can be used in cancer research [1].
|
-
- HY-D0023
-
|
HPTS; Solvent Green 7
|
Fluorescent Dye
|
Others
|
|
Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu + ion(λex=450 nm, λem=510 nm) [1] .
|
-
- HY-118320
-
|
Mordant orange 1
|
Fluorescent Dye
|
Others
|
|
Alizarine Yellow R (Mordant orange 1), a salicylic acid derivative, is a azo dye. Alizarine Yellow R is mostly used as a pH indicator, as a biological stain in chemical examinations and also in dyeing industries [1].
|
-
- HY-D1069
-
|
DBCO-Sulfo-Cy3
|
Fluorescent Dye
|
Others
|
|
DBCO-Cy3 (DBCO-Sulfo-Cy3) is the derivative of Cyanine3 fluorophore, a pH insensitive from pH (4-10) orange fluorescent dyewith excitation maximum 555 nm and emission maximum of 580nm. DBCO-Cy3 has fast reaction kinetics and good stability, and is productive to use in many standard fluorescent instrumentations. DBCO-Cy3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-W019885A
-
|
Sodium tripHospHate pentabASIC, 98%
|
Biochemical Assay Reagents
|
Others
|
|
Sodium tripolyphosphate (STPP), 98% is a biochemical reagent that can be used as pH adjustment, chelating agent, and detergent additive [1].
|
-
- HY-131087
-
|
|
ADC Linker
|
Cancer
|
|
Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
|
-
- HY-158122
-
|
|
DNA-PK
|
Cancer
|
|
Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules. Lys(CO-C3-p-I-Ph)-O-tBu can increase the residence time of PSMA ligand in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-O-tBu also reduces salivary gland absorption, possibly extending the half-life of the active compound. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) [1] .
|
-
- HY-P5172
-
|
|
Sodium Channel
|
Neurological Disease
|
|
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels [1].
|
-
- HY-133426
-
|
Ald-benzyl-amide-PEG4-propargyl
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Ald-Ph-amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W110898
-
|
|
Fluorescent Dye
|
Others
|
|
Nile blue chloride is a highly fluorescent and photostable organic dye. Nile blue chloride and fluorescein isothiocyanate (FITC) can be used to construct a ratiometric pH sensitive probe for tracking the pH of the extracellular fluid between cancer cells in realtime. Nile Blue chloride has the potential for the research of nonlinear optics [1] .
|
-
- HY-133546
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-amido-PEG11-C2-NH2 is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
|
-
- HY-163961
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S)-Thalidomide-NH-cyclohexane-NH-Ph-NH2 (Compound C63) is the E3 ligase + linker of (HY-163938) PROTAC, which contains Thalidomide-based cereblon ligand and 1 linker and can be used for synthesis PROTAC [1].
|
-
- HY-140337
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ph-Bis(C1-N-(C2-NH-Boc)2) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-153195
-
|
|
Others
|
Cancer
|
|
Tetra-O-acetyl-β-D-galactopyranosyl-Ph-CH2OH-Fmoc can be used as conjugates to prepare antibody drug conjugates (ADCs) [1].
|
-
- HY-130969
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-PEG4-bis-PEG3-N3 is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Ald-Ph-PEG4-bis-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W019885
-
|
Sodium tripHospHate pentabASIC, 85%
|
Biochemical Assay Reagents
|
Others
|
|
Sodium tripolyphosphate (STPP), 85% (Sodium triphosphate pentabasic, 85%) is a biochemical reagent that can be used as pH adjustment, chelating agent, and detergent additive [1].
|
-
- HY-W094475D
-
|
Epsom salts, meets analytical specification of pH. Eur. BP USP FCC
|
Biochemical Assay Reagents
|
Cardiovascular Disease
Cancer
|
|
Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC is currently the anticonvulsant of choice for the prevention and control of eclamptic fits. Magnesium sulfate is also widely used as a tocolytic agent [1] .
|
-
- HY-D0169
-
|
pHenolsulfonepHthalein
|
Fluorescent Dye
|
Others
|
|
Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction [1] .
|
-
- HY-P2818B
-
|
Apase, Chicken Intestine
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Alkaline phosphatase, Chicken Intestine (Apase, Chicken Intestine) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values [1].
|
-
- HY-163235
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Phenyl phenylcarbamate-CH-5-methoxypicolinamide-CH-CH-Ph-CF3 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.
|
-
- HY-D0227
-
|
Tris; Tris(hydroxymethyl)aminomethane
|
Biochemical Assay Reagents
|
Metabolic Disease
Cancer
|
|
THAM (Tris) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM is an effective amine compound for pH control in the physiological range [1].
|
-
- HY-D0227B
-
|
Tris acetate; Tris(hydroxymethyl)aminomethane acetate
|
Biochemical Assay Reagents
|
Metabolic Disease
Cancer
|
|
Trometamol acetate (Tromethamine acetate) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. Trometamol acetate is an effective amine compound for pH control in the physiological range [1].
|
-
- HY-169364
-
|
|
PD-1/PD-L1
|
Others
|
|
2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc is the PD-L1 ligand-linker conjugate part of AUTAC PD-L1 degrader-3 (HY-169363). 2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc can be utilized in AUTAC synthesis [1].
|
-
- HY-D0227A
-
|
Tris HCl; Tris(hydroxymethyl)aminomethane hydrochloride
|
Biochemical Assay Reagents
|
Metabolic Disease
Cancer
|
|
THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM hydrochloride is an effective amine compound for pH control in the physiological range [1] .
|
-
- HY-D0859
-
|
|
Biochemical Assay Reagents
|
Others
|
|
MOPS are commonly used as buffers in biology. MOPS buffer maintains the pH of mammalian cell culture media. MOPS and Tris buffer also have inhibitory effects on TfCut2 and LCC hydrolases, inhibiting the rate of hydrolyzing PET films. MOPS may also interfere with calcium binding, translocation, and utilization in vascular smooth muscle cells [1] .
|
-
- HY-P2818D
-
|
Apase, Human liver
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Alkaline phosphatase (Apase), Human liver is a glycoprotein bound to plasma membranes that hydrolyzes several monophosphate esters optimally at an alkaline pH with the release of inorganic phosphates [1].
|
-
- HY-D0009
-
|
|
Fluorescent Dye
|
Others
|
|
Bromocresol green sodium is an anionic dye. Bromocresol green sodium can be used for pH indication and DNA agarose gel electrophoresis. Bromocresol green sodium is also used in mammalian albumin measurement. Bromocresol green sodium deprotonates and produces the monoanionic form of yellow colour at lower pH (acidic condition), and produces dianionic blue colour at the basic condition [1].
|
-
- HY-W133967
-
-
- HY-D0874
-
|
|
Biochemical Assay Reagents
|
Others
|
|
HEPPSO is a zwitterionic buffer. The working pH range of HEPPSO buffer is 7.1-8.5. HEPPSO displays relatively high ability to bind copper(II), has a pKa of 7.84 at 2.0 mM buffer concentration [1] .
|
-
- HY-D1463
-
-
- HY-161652
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is the conjugate of a linker and a ligand for E3 ligase. Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione can be used for synthesis of PROTAC BRD4 Degrader-26 (HY-161650) [1].
|
-
- HY-W072496
-
|
|
Photosensitizer
Endogenous Metabolite
|
|
|
10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate is a photocatalyst with the activity of enhancing the efficiency of organic reactions. 10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate is widely used in the synthesis of complex molecules and compounds. 10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate also exhibits excellent performance in photosensitization reactions.
|
-
- HY-118155
-
|
|
Fluorescent Dye
|
Others
|
|
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H +/solute antiport system [1].
|
-
- HY-168244
-
|
|
PROTAC Linkers
|
Cancer
|
|
TsO-C2-Piperidine-O-azetidine-CO-Ph-C2-OH is a PROTAC linker, and can be used for PROTAC synthesis, such as PROTAC BRM/BRG1 degrader-1 (HY-168242) [1].
|
-
- HY-159077
-
|
|
PROTAC Linkers
|
Cancer
|
|
H2N-C6-NH-CO-CH2-O-Ph-CH2-NH-Boc is a linker. H2N-C6-NH-CO-CH2-O-Ph-CH2-NH-Boc can be utilized for synthesis of PROTAC BET Degrader-12 (HY-158764) [1].
|
-
- HY-D0227R
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
Cancer
|
|
THAM (Standard) is the analytical standard of THAM. This product is intended for research and analytical applications. THAM (Tris) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM is an effective amine compound for pH control in the physiological range [1].
|
-
- HY-128931
-
|
PROTAC Linker 31
|
PROTAC Linkers
|
Cancer
|
|
NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs [1].
|
-
- HY-Y1325H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al is an inorganic salt that can be used for life science related research [1].
|
-
- HY-D0878
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TAPSO is a common biological buffer, a pH stabilization reagent, with effective pH ranging from 7-8, and pKa values ranging from 7.5–9.0. TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides [1].
|
-
- HY-D0227AR
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
Cancer
|
|
THAM (hydrochloride) (Standard) is the analytical standard of THAM (hydrochloride). This product is intended for research and analytical applications. THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM hydrochloride is an effective amine compound for pH control in the physiological range [1] .
|
-
- HY-Y1184C
-
|
Potassium hydrogen carbonate, meets analytical specification of pH. Eur., BP, USP, E501, 99.5%(T)
|
Biochemical Assay Reagents
|
Others
|
|
Potassium bicarbonate (Potassium hydrogen carbonate) is a commonly used biochemical reagent. Potassium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, E501, 99.5%(T) can be used as a biomaterial related to life science research [1].
|
-
- HY-W694629
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Triethylammonium bicarbonate is a biochemical reagent that can be used to prepare buffer solutions that maintains the stable pH environment required for processes such as enzyme-catalyzed reactions [1].
|
-
- HY-W411215
-
|
|
Fluorescent Dye
|
Others
|
|
1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH [1].
|
-
- HY-153196
-
|
|
ADC Linker
|
Others
|
|
Tetra-O-acetyl-β-D-galactopyranosyl-Ph-CH2-(4-nitrophenyl)carbonate-Fmoc (Example 2.28.6) is an ADC linker that can be used to synthesize antibody-conjugated active molecules (ADCs) [1].
|
-
- HY-108535
-
|
|
Biochemical Assay Reagents
|
Others
|
|
HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis [1] .
|
-
- HY-W100209
-
|
|
Potassium Channel
|
Others
|
|
5Me3F4AP is a potent blocker of potassium channel, with the IC50 of 220 μM to 693 μM when the pH is increased from 6.4 to 9.1. 5Me3F4AP has the potential to cross the blood-brain barrier and potential application in positron emission tomography (PET) [1].
|
-
- HY-145576
-
|
|
Fluorescent Dye
|
Others
|
|
2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH [1].
|
-
- HY-W440988
-
|
|
Liposome
|
Others
|
|
DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner [1] .
|
-
- HY-117683
-
|
|
TRP Channel
|
Neurological Disease
|
|
BCTP is a TRPV1 antagonist. BCTP activated at low pH showed functional antagonist activity against human TRPV1 in CHO cells (IC50=18 nM). BCTP can be used in the study of chronic pain [1].
|
-
- HY-D1200
-
|
Solvent Green 1
|
Fungal
Parasite
|
Others
|
|
Malachite Green Carbinol base (MGOH, MGCB) is a derivative of Malachite green (MG) with not fluorescence. Malachite green carbinol base (MGOH, MGCB), as a pH regulation reagent, MGCB molecule could release OH - under UV light irradiation and generate a progressive shift in pH values. MGCB solution turns from colorless to deep green rapidly when exposed to a high-pressure UV lamp (500 W, 50 W/cm) [1] .
|
-
- HY-D1591
-
|
|
Fluorescent Dye
|
Others
|
|
BODIPY R6G methyl ester (compound 5′-1) is a BODIPY-like fluorescent dye with good light stability and insensitive to pH value. BODIPY R6G methyl ester shows good photostability, high sensitivity and insensitive to pH value. BODIPY R6G methyl ester can be used in research areas such as photodynamic research, PH probes, ion recognition, photocatalysis, protein labeling, cell imaging, and proteomic analysis [1].
|
-
- HY-105033
-
|
Pirfloxacin
|
Bacterial
|
Infection
|
|
Irloxacin (Pirfloxacin) is a quinolone antibacterial agent. Irloxacin shows greater activity with an acid pH. Irloxacin has a good in vitro antimicrobial spectrum against both gram-positive and gram-negative bacteria. Orally active [1].
|
-
- HY-D0142
-
|
|
Fluorescent Dye
|
Others
|
|
Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium is a fluorescent dye and pH indicator, also as a ligand of multifunctional metal-organic framework. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium has been used to detect CO2 release [1] .
|
-
- HY-B1422
-
|
Aminacrine
|
Bacterial
HIV
|
Infection
|
|
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections [1] .
|
-
- HY-D0872
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DIPSO is a biological zwitterionic buffer with the useful pH range from 7.0 to 8.2. DIPSO can interfere meiotic regulation in mouse oocytes. DIPSO also has surfactant activity at 10 mM [1] .
|
-
- HY-161653
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is a linker of PROTAC BRD4 Degrader-26 (HY-161650), and can be used for synthesis of PROTACs [1].
|
-
- HY-P10469
-
|
|
NF-κB
|
Inflammation/Immunology
Cancer
|
|
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc [1].
|
-
- HY-148825
-
-
- HY-113697
-
|
Mal-PEG2-AZD
|
PROTAC Linkers
|
Cancer
|
|
Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (Mal-PEG2-AZD) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].
|
-
- HY-D1694
-
|
|
Fluorescent Dye
|
Others
|
|
LysoTracker Yellow HCK 123 is a potent yellow membrane-permeable fluorescent probe. LysoTracker Yellow HCK 123 is a weakly basic amine that selectively accumulates in cellular compartments with low luminal pH. (λex=465 nm, λem=535 nm) [1].
|
-
- HY-B1422R
-
|
|
Bacterial
HIV
|
Infection
|
|
9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections [1] .
|
-
- HY-20794
-
|
|
Fluorescent Dye
|
Others
|
|
8-Hydroxyjulolidine is a chromophore moiety of a fluorescent probe for the detection of weak acid ions. 8-Hydroxyjulolidine can be used to synthesize the salicylaldehyde derivative 9-formyl-8-hydroxyjulolidine, which exhibits sensitive detection ability to pH changes of hydrogen sulfide and silicate in aqueous solution [1].
|
-
- HY-W129456
-
|
|
Others
|
Neurological Disease
|
|
Isaxonine acts as a modifier of the surface pH of the bilayer [1]. Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery . Isaxonine is a neurotrophic agent .
|
-
- HY-145576B
-
|
|
Fluorescent Dye
|
Others
|
|
2-Amino-8-oxononanoic acid (hydrochloride) is the hydrochloride form of 2-Amino-8-oxononanoic acid. 2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH [1].
|
-
- HY-41549
-
|
Cereblon Ligand-Linker Conjugates 9; E3 Ligase Ligand-Linker Conjugates 2
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
|
-
- HY-U00017
-
-
- HY-D1445
-
|
|
Fluorescent Dye
|
Metabolic Disease
|
|
PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes (Abs=329 nm; Em=440 nm) [1].
|
-
- HY-B1329
-
|
Nebramycin II sulfate
|
Bacterial
Antibiotic
|
Infection
|
|
Apramycin (EBL 1003) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic [1] .
|
-
- HY-159543
-
-
- HY-D0015
-
-
- HY-W088071
-
-
- HY-B1329R
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Apramycin (sulfate) (Standard) is the analytical standard of Apramycin (sulfate). This product is intended for research and analytical applications. Apramycin (EBL 1003) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic [1] .
|
-
- HY-145575
-
|
pH10
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
Itruvone is a intermediate of 17α-ethinylestradiol (EE2) during Fenton oxidation. Itruvone has an antidepressant effect [1] . Itruvone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-P10105
-
|
|
Akt
Apoptosis
|
Cancer
|
|
TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo [1].
|
-
- HY-17507
-
|
BY1023; SKF96022
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) [1]. Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-17507A
-
|
BY1023 sodium; SKF96022 sodium
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) [1]. Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-17507B
-
|
BY1023 sodium hydrate; SKF96022 sodium hydrate
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) [1]. Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-116033
-
|
|
Ser/Thr Protease
|
Inflammation/Immunology
|
|
BMS-363131 is a selective inhibitor for tryptase, with an IC50 <1.7 nM. BMS-363131 is hydrolytic stable at pH=7 and pH=9. BMS-363131 attenuates the astham in a guinea pig model [1].
|
-
- HY-W025785
-
|
Solvent Yellow 2; Dimethyl yellow
|
Others
|
Others
|
|
Methyl yellow (Solvent Yellow 2) is a pH indicator. Methyl yellow appears red at low pH, and becomes yellow above pH 4.0 [1].
|
-
- HY-W110789
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Ethyl Orange (sodium), indicator grade is an organic azo compound that can be used as a pH indicator from pH 3.0 to pH 4.8, changing color from red to orange.
|
-
- HY-17507R
-
|
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Pantoprazole (Standard) is the analytical standard of Pantoprazole. This product is intended for research and analytical applications. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) [1]. Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-17507BR
-
|
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Pantoprazole (sodium hydrate) (Standard) is the analytical standard of Pantoprazole (sodium hydrate). This product is intended for research and analytical applications. Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) [1]. Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-125457
-
|
p-NapHtolbenzein
|
Fluorescent Dye
|
Others
|
|
α-Naphtholbenzein (p-Naphtolbenzein) is a dye. α-Naphtholbenzein can be used as a pH indicator. α-Naphtholbenzein has a visual transition from yellow (pH0-8.2) to turquoise (pH10). α-Naphtholbenzein is often used during sequential injection analysis technique done for acid-base titrations [1].
|
-
- HY-D0011
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bromophenol blue sodium is a pH indicator. It changes from yellow at pH 3.0 to blue at pH 4.6. Bromophenol blue sodium is also used as a tracking dye to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis [1] .
|
-
- HY-D0856
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) [1] .
|
-
- HY-113377
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2 [1] .
|
-
- HY-113377A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2 [1] .
|
-
- HY-19548A
-
|
|
Arginase
|
Metabolic Disease
|
|
BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively [1].
|
-
- HY-100230A
-
|
|
Potassium Channel
|
Others
|
|
ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 [1].
|
-
- HY-157036
-
|
|
Fluorescent Dye
|
Others
|
|
INSA is a a pH-sensitive fluorescent probe. INSA can simultaneously light up mitochondria (red emission) and lysosomes (green emission) for their internal pH differences [1].
|
-
- HY-D0075
-
|
|
Fluorescent Dye
|
Others
|
|
DHPDS disodium salt is a pH-sensitive fluorescent dye. DHPDS disodium salt is used to measure intracellular pH (pHi) from the surface fluorescence of the isolated perfused rat liver [1].
|
-
- HY-D0012
-
-
- HY-101882
-
BCECF
1 Publications Verification
2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein
|
Fluorescent Dye
|
Others
|
|
BCECF is a pH-sensitive fluorescent dye. BCECF allows measurements in the physiological pH range 6.0–8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm.
|
-
- HY-123184
-
-
- HY-D0856R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-Tris (Standard) is the analytical standard of Bis-Tris. This product is intended for research and analytical applications. Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) [1] .
|
-
- HY-W331502
-
-
- HY-W110784
-
-
- HY-W342120
-
-
- HY-N2383
-
|
(1R,2S,3S,4S,6R)-4-Amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol
|
Glycosidase
|
Metabolic Disease
|
|
Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC50 value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme [1].
|
-
- HY-148530
-
|
|
PROTACs
CDK
|
Cancer
|
|
YX-2-107 is a PROTAC (IC50= 4.4 nM) that selectively degrades CDK6. YX-2-107 effectively inhibits RB phosphorylation and FOXM1 expression in vitro and inhibits the development of Ph + ALL in rats. YX-2-107 can be used in the study of Ph chromosome-positive (Ph +) acute lymphoblastic leukemia (ALL) [1].
|
-
- HY-W110790
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bromocresol purple (sodium) is a water-soluble dye, bromocresol purple sodium, commonly known as bromocresol purple, used as a pH indicator. The dye color changes from yellow to purple between pH 5.2 and 6.8.
|
-
- HY-159478
-
-
![CHO-Ph-spiro[3.3]heptane-COOEt](//file.medchemexpress.eu/product_pic/hy-159478.gif)
- HY-D2119
-
|
|
Fluorescent Dye
|
Cancer
|
|
CQ-Lyso is a lysosome-targeting chromenoquinoline. CQ-Lyso is a fluorescent probe for measuring the pH of lysosomes in living cells using only single wavelength excitation. CQ-Lyso can visualize the dynamic pH changes in lysosomes [1].
|
-
- HY-135226
-
|
|
Others
|
Others
|
|
PROLI NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1.8 seconds at 37°C (pH 7.4) to liberate 2 moles of NO per mole of parent compound.
|
-
- HY-W923277
-
|
|
Biochemical Assay Reagents
|
|
|
Sodium sesquicarbonate hydrate is a kind of buffering agent that can stabilize pH value by neutralizing acidic substances without causing a sharp change in pH value. This property makes it widely used in many fields, especially in maintaining acid-base balance in organisms.
|
-
- HY-W040144
-
|
|
Fluorescent Dye
|
Others
|
|
Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells [1] .
|
-
- HY-145616
-
-
- HY-D0012A
-
-
- HY-124348
-
|
3,5-Dimethyl PIT-1
|
PI3K
|
Cancer
|
|
DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor [1]. DM-PIT-1 has the potential for the research of ovarian cancer [1].
|
-
- HY-D0305
-
|
|
Fluorescent Dye
|
Others
|
|
Tropaeolin O is an acidic monoazo dye that undergoes a coupling reaction under pH=10.5 conditions to form a blue disazo dye. Tropaeolin O can be used for the determination of palladium(II), osmium(IV), albumin, and casein [1].
|
-
- HY-W087928
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bromocresol purple is a pH indicator, whose color changes from yellow to purple when the pH increases from 5.2 to 6.8. Bromocresol purple can be used for detecting yeast cells with plasma membrane damage [1] .
|
-
- HY-D1111
-
|
AFDye 568 NHS Ester
|
Fluorescent Dye
|
Others
|
|
TFAX 568, SE is an orange fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 568, SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG) [1].
|
-
- HY-W507393
-
|
DPTA-NO
|
Biochemical Assay Reagents
|
Others
|
|
Dipropylenetriamine NONOate (DPTA-NO) is a NO donor, which spontaneously dissociates in a pH-dependent, first-order process with a half-life of three hours and five hours at 37°C and 22-25°C, pH 7.4, respectively [1] .
|
-
- HY-W353607A
-
-
- HY-D0228
-
|
Azo Violet; Magneson I
|
Fluorescent Dye
|
Others
|
|
4-(4-Nitrophenylazo)resorcinol is an azo purple dye used experimentally as a pH indicator, showing yellow when the pH value is lower than 11 and purple when the pH value is higher than 13. In slightly alkaline or alkaline environments, it also turns dark blue in the presence of magnesium salts. Azo Violet can also be used to test for the presence of ammonium ions. The color of the ammonium chloride or ammonium hydroxide solution will change depending on the concentration of azo violet used.
|
-
- HY-D1110
-
|
|
Fluorescent Dye
|
Others
|
|
TFAX 594,SE is a red fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 594,SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG) [1].
|
-
- HY-107757
-
|
|
Sodium Channel
|
Neurological Disease
|
|
GMQ is a ASIC (acid-sensing ion) channel activator with an EC50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research [1].
|
-
- HY-P4579
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Pyr-Phe-OH is an effective pyrene-based hydrogel. Pyr Phe OH can self-assemble into hydrogels in the range of pH=7.5-14.0, and also shows a very low gel concentration (0.037% (w/v)) in phosphate buffer [1].
|
-
- HY-155386
-
-
- HY-D1113
-
|
|
Fluorescent Dye
|
Others
|
|
TFAX 488,TFP is a green fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 488,TFP yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG, streptavidin) [1].
|
-
- HY-W008865
-
|
|
Biochemical Assay Reagents
|
Others
|
|
PIPES sesquisodium is a pH buffer. PIPES refers to Piperazine N-N’-bis [2 ethanol sulphonic acid, an organic based buffer. PIPES can be used in the preparation of a variety of marine and mammalian tissues for electron microscopic study, with pH range of 6.1-7.5 [1].
|
-
- HY-128545
-
|
Nitrazine paper; pHenapHthazine
|
Biochemical Assay Reagents
|
Others
|
|
Nitrazine yellow (Nitrazine paper; Phenaphthazine) is a pH indicator. The color of Nitrazine yellow changes from yellow to blue in the pH range from 6.0 to 7.0. Nitrazine yellow is a kind of biological materials or organic compounds that are widely used in life science research [1].
|
-
- HY-D0858B
-
|
2-MorpHolinoethanesulpHonic acid sodium salt
|
Biochemical Assay Reagents
|
Others
|
|
MES (2-Morpholinoethanesulphonic acid) sodium salt is a buffering agent in biology and biochemistry. MES sodium salt is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES sodium salt is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments [1] .
|
-
- HY-W250149
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chlorophosphonazo III is a sensitive reagent for both calcium and magnesium. It is possible to determine calcium alone at pH 2.2 and calcium and magnesium at pH 7.0. Chlorophosphonazo III can also be used for the spectrophotometric determination of titanium, zirconium, thorium, and scandium, quinquevalent actinide elements, and protactinium [1].
|
-
- HY-D1401
-
|
|
Fluorescent Dye
|
Others
|
|
OG 488, acid, a fluorescent pH indicator, has many applications in biochemistry and neurosciences [1].
|
-
- HY-148949A
-
|
|
Kallikrein
|
Others
|
|
Kallikrein 5-IN-2 TFA is the TFA salt form of Kallikrein 5-IN-2 (HY-148949). Kallikrein 5-IN-2 TFA is a selective inhibitor for kallikrein 5 (KLK5) with pIC50 of 7.1. Kallikrein 5-IN-2 TFA is non-phototoxic (100 μg/mL) and non-irritant. Kallikrein 5-IN-2 is stable at pH 4-pH 8 under non-oxidative condition. Kallikrein 5-IN-2 is potent in ameliorating the Netherton syndrome [1].
|
-
- HY-D1114
-
|
|
Fluorescent Dye
|
Others
|
|
TFAX 488,SE dilithium is a green fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 488,SE dilithium yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG, streptavidin) [1].
|
-
- HY-131007
-
|
|
Adrenergic Receptor
|
Metabolic Disease
|
|
FFN270 hydrochloride, a fluorescent tracer of norepinephrine, is a fluorescent substrate of the norepinephrine and vesicular monoamine transporters. FFN270 hydrochloride exhibits two resolved absorption/excitation maxima depending on solvent pH (FFN270 ex: 320 nm or 365 nm, em: 475 nm) and can function as ratiometric fluorescent pH-sensors [1].
|
-
- HY-D0050
-
|
|
Fluorescent Dye
|
Others
|
|
5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester (cDCFDASE) is a fluorescent probe. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester can be used to evaluate the intracellular pH (pHin) of living cells at a medium pH (pHex) [1].
|
-
- HY-P99037
-
|
M281
|
Fc Receptor (FcR)
|
Inflammation/Immunology
|
|
Nipocalimab (M281) is a fully human, recombinant, aglycosylated IgG1 monoclonal antibody. Nipocalimab is a human deglycosylated IgG1 anti-FcRn monoclonal antibody that binds with picomolar affinity to Fc receptor (FcRn) at both endosomal pH 6.0 and extracellular pH 7.6 [1] .
|
-
- HY-160764
-
|
|
Drug Derivative
|
Others
|
|
N6-Carboxymethyl-ATP is the alkylation product of ATP with iodoacetic acid at pH 6.5, where alkylation of ATP with iodoacetic acid at pH 6.5 yielded 1-carboxymethyl-ATP which, after alkaline rearrangement gave N6-carboxymethyl-ATP [1].
|
-
- HY-137873
-
|
4-Methylumbelliferyl-α-D-Glucose; 4-Methylumbelliferyl-α-D-Glucoside; 4-MU-α-D-Glucopyranoside
|
Fluorescent Dye
Glycosidase
|
Others
|
|
4-Methylumbelliferyl-α-D-Glucopyranoside (4-Methylumbelliferyl-α-D-Glucose) is a fluorescent substrate for α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage. 4-MU has pH-dependent fluorescence excitation activity, with excitation wavelengths of 320 nm at low pH (1.97-6.72) and 360 nm at high pH (7.12-10.3), respectively. The emission wavelength of 4-Methylumbelliferyl-α-D-Glucopyranoside increases with decreasing pH, ranging from 445-455 nm. 4-Methylumbelliferyl-α-D-Glucopyranoside can be used as a biomarker for Fabry and Pompe diseases to quantify α-glucosidase activity in infant blood spot samples.
|
-
- HY-101883
-
|
|
Fluorescent Dye
|
Others
|
|
BCECF-AM is a cell membrane permeable compound widely used as a fluorescent indicator for intracellular pH.
|
-
- HY-110337
-
|
|
Others
|
Others
|
|
FFN 102 mesylate is a synthetic biogenic neurotransmitter analogue with PH-dependent fluorescence and electrical activity [1].
|
-
- HY-164367
-
-
- HY-W739302
-
|
Sodium α-oxyhyponitrite
|
Others
|
Others
|
|
Sodium Oxyhyponitrite Angeli (Angeli) is a nitroxyl (NO-) donor, but under certain conditions NO release has also been observed. Sodium Oxyhyponitrite Angeli spontaneously dissociates in a pH-dependent first-order process with a half-life of 2.3 minutes at 37°C (pH 7.4), releasing 0.54 mol NO per mole.
|
-
- HY-144768
-
|
|
Liposome
|
Others
|
|
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive [1].
|
-
- HY-118643
-
|
BMS-986231; CXL-1427
|
Others
|
Cardiovascular Disease
|
|
Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects [1] .
|
-
- HY-120742
-
|
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
|
MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC50 values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4 [1].
|
-
- HY-144025
-
|
|
Liposome
|
Others
|
|
DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery [1].
|
-
- HY-157379
-
-
- HY-126774
-
|
|
Fluorescent Dye
|
Others
|
|
DAF-FM is a diaminofluorescein, which can be used as fluorescent indicator for nitric oxide (NO) with good pH tolerance [1].
|
-
- HY-P1748
-
|
EC 3.4.24.27; TML
|
Endogenous Metabolite
|
Infection
|
Thermolysin, Bacillus thermoproteolyticus rokko (EC 3.4.24.27) (TML) is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues [1].
Optimal pH: 8.0. Considerably stable from pH 5 to 9.5.
Optimal temperature : 70 °C
|
-
- HY-155717
-
|
|
Autophagy
Pim
|
Cancer
|
|
NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation [1].
|
-
- HY-14878
-
|
(2R)-AZD-0837
|
Thrombin
|
Cardiovascular Disease
|
|
(2R)-Atecegatran ((2R)-AZD-0837; (Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab)) is a thrombin inhibitor. (2R)-Atecegatran can be used in research related to thromboembolic disorders [1].
|
-
- HY-W102681
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Caps sodium salt, a polyanion, is a surfactant. Caps sodium salt can be used as biological buffer (0.05 M, pH 11) for dialysis [1].
|
-
- HY-136283
-
|
|
Others
|
Neurological Disease
|
|
DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca 2+ selective cage, with a Kd for Ca 2+ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca 2+ (Kd=~2 nM) after photolysis [1] .
|
-
- HY-118907
-
|
|
Fluorescent Dye
|
Others
|
|
Methyl Orange is a soluble azo dye commonly used as an acid-base indicator and for staining cells and tissue sections, as well as for dyeing textiles. Methyl Orange appears red at a pH of 3.1 and changes to bright yellow as the pH increases to 4.4. Methyl Orange (500 mg/L) exhibits cytotoxicity and can cause DNA damage [1] .
|
-
- HY-E70063
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
alpha-2,3-Sialyltransferase (Phα2,3SiaT) is a beta-galactoside. alpha-2,3-Sialyltransferase (Phα2,3SiaT) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids [1].
|
-
- HY-19153
-
|
rel-TY-11345 free base
|
Proton Pump
|
Inflammation/Immunology
|
|
Nepaprazole (rel-TY-11345 free base) is a proton pump inhibitor. Nepaprazole inhibits H +/K +-ATPase activity in isolated rabbit gastric mucosal microsomes with the IC50 values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively. Nepaprazole can be used for study of peptic ulcer diseases [1].
|
-
- HY-159558
-
-
- HY-P1315
-
|
Glycylglycyl-L-tyrosyl-L-arginine
|
Cathepsin
|
Others
|
|
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to papain, with a Ki of 9 μM at pH 6.2 [1].
|
-
- HY-W013105
-
|
N-Cholylglycine sodium salt, 98%
|
Biochemical Assay Reagents
|
Others
|
|
Sodium glycocholate hydrate, 98% is a buffer commonly used in molecular biology and biochemical research, providing precise pH control in various experimental settings.
|
-
- HY-D0227F
-
|
Tris HCl (≥99%, reagent grade); Tris hydrochloride (≥99%, reagent grade)
|
Biochemical Assay Reagents
|
Others
|
|
THAM hydrochloride (≥99%, reagent grade), also known as Tris-HCl, is a buffer commonly used in various biochemical and molecular biology applications to maintain a stable pH environment. Tris-HCl has unique chemical properties that allow it to resist changes in pH when acidic or basic substances are added, which makes it useful for stabilizing biological samples or reagents. It is commonly used in electrophoresis and protein purification procedures.
|
-
- HY-158082C
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 70000
|
Fluorescent Dye
|
Others
|
|
TRITC-dextran, MW 70000 (Tetramethyl rhodamine isothiocyanate glucan, MW 70000) is a fluorescent dye, with the molecular weight of 70 kD. TRITC-dextran, MW 70000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 70000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
-
- HY-D1366
-
|
|
Fluorescent Dye
|
|
|
Sulfo-Cyanine5.5 carboxylic acidCI Pigment violet 32 is a water-soluble, far-red emitting fluorophore. Due to its four sulfo groups, this dye has a negative charge at neutral pH and is very hydrophilic. As a cyanine dye, sulfo-Cyanine5.5 shows a very low dependence of fluorescence on pH and a very high extinction coefficient.
|
-
- HY-133527
-
|
Oregon green 488 succinimidyl ester
|
Fluorescent Dye
|
Neurological Disease
|
|
OG 488, SE (Oregon green 488 succinimidyl ester), a fluorescent pH indicator, has many applications in biochemistry and neurosciences [1] .
|
-
- HY-D0166
-
|
|
Fluorescent Dye
|
Others
|
|
Neutral Red, a nitrogenous pH-indicator with a pKi of 6.8, is an indicator for the internal acidification of thylakoids. Neutral Red stains lysosomes red [1].
|
-
- HY-D0869
-
|
N-Cyclohexyl-3-aminopropanesulfonic acid
|
Biochemical Assay Reagents
|
Others
Cancer
|
|
CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis [1] .
|
-
- HY-W096988A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sodium 1-hexanesulfonate (monohydrate) is an ion-pairing reagent and pH buffer used in the analysis of small organic compounds, pharmaceuticals, and metabolites by techniques such as HPLC.
|
-
- HY-W105686
-
|
|
Biochemical Assay Reagents
|
Others
|
|
MOPS hemisodium salt, 98% is a buffer commonly used in molecular biology and biochemical research, providing precise pH control in various experimental settings.
|
-
- HY-D0077
-
|
Oregon green 488
|
Fluorescent Dye
|
Others
|
|
2',7'-Difluorofluorescein (Oregon green 488) can be used to measure the pH of aerosol particles in the range of 2-7 [1].
|
-
- HY-D1477
-
|
|
Fluorescent Dye
|
Others
|
|
5(6)-Carboxyfluorescein diisobutyrate is a protected 5(6)-carboxyfluorescein. 5(6)-carboxyfluorescein is a fluorescence pH indicator [1].
|
-
- HY-155667
-
|
|
Others
|
Others
|
|
Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range [1].
|
-
- HY-155667A
-
|
|
Cathepsin
|
Others
|
|
Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range [1].
|
-
- HY-136672
-
|
|
Fluorescent Dye
|
Others
|
|
(E)-HBT-O is an isomer of HBT-O. HBT-O is a fluorescent probe used to monitor subtle pH fluctuations in living cells [1].
|
-
- HY-119853
-
|
NSC-17262
|
Others
|
Infection
|
|
Bayer A 139 is an ethylene-menaquinone that inactivates fowl plaque virus activity. Bayer A 139 can react with nucleic acids at pH ≦ 7 [1].
|
-
- HY-159093
-
|
|
Others
|
Cancer
|
|
GSCs-IN-1 (compound 4 h) is a potent and selective GSCs inhibitor. GSCs-IN-1 has the potential for the research of cancer [1].
|
-
- HY-159487
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(2S,4R)-4-Hydroxy-1-((S)-2-(6-(4-methoxyphenyl)spiro[3.3]heptane-2-carboxamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide is an E3 ligase ligand-linker conjugate.
|
-
![(S,R,S)-AHPC-CO-spiro[3.3]heptane-Ph-CHO](//file.medchemexpress.eu/product_pic/hy-159487.gif)
- HY-15942
-
5-TAMRA
2 Publications Verification
|
Fluorescent Dye
|
Others
|
|
5-TAMRA can produce bright, pH-insensitive orange-red fluorescence (excitation and emission extremes of 546/579) and has good photostability.
|
-
- HY-D0048
-
|
5-TAMRA-NHS ester; 5-Carboxytetramethylrhodamine succinimidyl ester
|
Fluorescent Dye
|
Others
|
|
5-TAMRA-SE is an amine-reactive fluorescent agent, and its conjugate produces bright, pH-insensitive orange-red fluorescence with good photostability.
|
-
- HY-W105704
-
|
|
Biochemical Assay Reagents
|
Others
|
|
HEPBS is a zwitterionic buffering agent with a pH range (7.6-9.0) similar to that of biological systems. HEPBS can be used in the culture of cells [1].
|
-
- HY-P2729
-
|
EC 3.4.21.14
|
Ser/Thr Protease
|
Others
|
|
Subtilisin, or rubinase, is a bacterial serine protease. Subtilisin can be used as a detergent additive with thermal stability, pH tolerance, and calcium dependent stability [1] .
|
-
- HY-121598
-
|
SC-36602
|
Apoptosis
|
Cardiovascular Disease
|
|
Actisomide (SC-36602) is an antiarrhythmic agent. Absorption of actisomide in rats and its in vitro uptake in CaCo-2 cells are pH-dependent [1].
|
-
- HY-155224
-
|
Sulfi/NO
|
NO Synthase
|
Others
|
|
Sulpho NONOate (Sulfi/NO) does not produce NO at physiological pH. Sulpho NONOate can be used in the experiments about other NO-donor regents as a negative control [1].
|
-
- HY-109541S6
-
|
(Rac)-DMPC-d72
|
Isotope-Labeled Compounds
|
Others
|
|
(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d72 is deuterium labeled (Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-ph
|
-
- HY-125066
-
|
|
Bacterial
|
Infection
|
|
Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.
|
-
- HY-P99965
-
|
SKY59; RO7112689
|
Complement System
|
Cardiovascular Disease
Metabolic Disease
|
|
Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research [1] .
|
-
- HY-Y0367R
-
|
|
Endogenous Metabolite
Bacterial
|
Infection
|
|
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
IC50 & Target: GAD [1] .
In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .
|
-
- HY-17608
-
|
GSK1278863
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
|
Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
|
-
- HY-D0867
-
|
|
Biochemical Assay Reagents
|
Others
|
|
BES is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES is used in the diagnostic testing area.
|
-
- HY-D0867A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
BES sodium is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES sodium is used in the diagnostic testing area.
|
-
- HY-D1556
-
|
1,2-dioleoyl-sn-glycero-3-pHospHoethanolamine-N-(carboxyfluorescein) ammonium
|
Fluorescent Dye
|
Others
|
|
DOPE-CF is a pH-sensitive fluorescent membrane labelled probe with a fluorescein moiety that is a weak acid and a conjugated base that is highly fluorescent and can be attached to phospholipid ethanolamine lipids [1].
|
-
- HY-15923
-
|
|
Reactive Oxygen Species
|
Others
|
|
MAOS is a modified Trinder’s reagent that can be used as a chromogenic probe for the determination of H2O2. MAOS is strongly dependent on the pH of the reaction medium [1].
|
-
- HY-129097
-
|
|
Fluorescent Dye
|
Others
|
|
FFN-102 trifluoroacetate is an analogue of biogenic neurotransmitters. FFN-102 trifluoroacetate is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals [1].
|
-
- HY-W099337
-
|
|
Biochemical Assay Reagents
|
|
|
N-Ethyl-D-glucamine is a glucose derivative with biological activity as a buffer and chelating agent. Therefore, it is widely used in biochemical research to regulate pH and bind metal ions.
|
-
- HY-129563
-
|
|
HIV
HIV Protease
|
Infection
|
|
CGP 57813 is a peptidomimetic inhibitor of HIV protease that can be encapsulated by nanoparticles composed of poly(D,L-lactic acid) (PLA) and pH-sensitive methacrylic acid copolymers and delivered into the body [1].
|
-
- HY-169960
-
|
|
mTOR
|
Cancer
|
|
2DII is a potent and selective mTORC2 inhibitor. 2DII selectively binds mSin1 PH domain and decreases the expression of AKT1 phosphorylation [1].
|
-
- HY-158082D
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 150000
|
Fluorescent Dye
|
Others
|
|
TRITC-dextran, MW 150000 (Tetramethyl rhodamine isothiocyanate glucan, MW 150000) is a fluorescent dye, with the molecular weight of 150 kD. TRITC-dextran, MW 150000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 150000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 150000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
-
- HY-158082E
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 500000
|
Fluorescent Dye
|
Others
|
|
TRITC-dextran, MW 500000 (Tetramethyl rhodamine isothiocyanate glucan, MW 500000) is a fluorescent dye, with the molecular weight of 500 kD. TRITC-dextran, MW 500000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 500000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 500000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
-
- HY-158082H
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 2000000
|
Fluorescent Dye
|
Others
|
|
TRITC-dextran, MW 2000000 (Tetramethyl rhodamine isothiocyanate glucan, MW 2000000) is a fluorescent dye, with the molecular weight of 2000 kD. TRITC-dextran, MW 2000000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 2000000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 2000000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
-
- HY-W747507
-
|
|
Bacterial
|
Infection
|
|
Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs=2 and >500 μg/mL at pH 3 and 7.4, respectively).2 Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s=1.6 and 1.3 μg/mL, respectively).
|
-
- HY-118907R
-
|
|
Fluorescent Dye
|
Others
|
|
Methyl Orange (Standard) is the analytical standard of Methyl Orange. This product is intended for research and analytical applications. Methyl Orange is a soluble azo dye commonly used as an acid-base indicator and for staining cells and tissue sections, as well as for dyeing textiles. Methyl Orange appears red at a pH of 3.1 and changes to bright yellow as the pH increases to 4.4. Methyl Orange (500 mg/L) exhibits cytotoxicity and can cause DNA damage [1] .
|
-
- HY-128476
-
|
|
Others
|
Others
|
|
Sodium Tartrate is a pH-Regulating agent with antioxidant activity. Sodium Tartrate is particularly effective retarding hydrolysis while heating at high temperatures, resulting in increase of acid values (AVs) of vegetable oils [1].
|
-
- HY-W002110
-
|
3-Hydroxy-4-methoxypHenylacetic acid; iso-HVA; Homoisovanillic acid
|
Endogenous Metabolite
|
Cancer
|
|
Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is extracted from urine at pH 2 by ethyl acetate. Isohomovanillic acid is not found in appreciable values in many normal human urines [1].
|
-
- HY-D0866
-
|
N-(2-Acetamido)-2-aminoethanesulfonic acid
|
Biochemical Assay Reagents
|
Others
|
|
ACES (N-(2-Acetamido)-2-aminoethanesulfonic acid) is a zwitterionic buffer. The working pH range of ACES buffer is 6.8-7.2 [1] .
|
-
- HY-N11071
-
|
|
Bacterial
|
Infection
|
|
Monascorubramine is a microbial colorant. Monascorubramine is capable of producing by the Monascus, which is from the bacteria Talaromyces. Under the condition of different pH value, the hue and chromaticity value of the colorant are also different [1].
|
-
- HY-P2818A
-
|
Apase, Escherichia coli
|
Endogenous Metabolite
|
Others
|
|
Alkaline phosphatase, Escherichia coli is a cytoplasm glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Escherichia coli can be used in molecular biology and enzyme-free analysis [1].
|
-
- HY-137303
-
|
FAGLA
|
Bacterial
|
Others
|
|
FA-Gly-Leu-NH2 (FAGLA) is a dipeptide substrate for proteases that can be hydrolyzed by thermophilic proteases and neutral proteases, showing pH-dependent variations in kcat/Km [1].
|
-
- HY-W460471
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tris Buffered Saline is a common buffer reagent in molecular biology, consisting of Tris and NaCl. Tris Buffered Saline can adjust pH and ionic strength and is widely used in DNA/RNA extraction, PCR and protein electrophoresis. Tris Buffered Saline can purify and protect nucleic acid materials and improve reaction efficiency and concentration. In protein electrophoresis, Tris Buffered Saline stabilizes gels and maintains pH. Overall, Tris Buffered Saline offers versatility, good solubility, and low toxicity in molecular biology applications.
|
-
- HY-158082
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 4000
|
Fluorescent Dye
|
Others
|
|
TRITC-dextran MW 4000 (Tetramethyl rhodamine isothiocyanate glucan, MW 4000) is a fluorescent dye, with the molecular weight of 4 kD. TRITC-dextran MW 4000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 4000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 4000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
-
- HY-158082A
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 20000
|
Fluorescent Dye
|
Others
|
|
TRITC-dextran, MW 20000 (Tetramethyl rhodamine isothiocyanate glucan, MW 20000) is a fluorescent dye, with the molecular weight of 20 kD. TRITC-dextran MW 20000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 20000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 20000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
-
- HY-158082B
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 40000
|
Fluorescent Dye
|
Others
|
|
TRITC-dextran, MW 40000 (Tetramethyl rhodamine isothiocyanate glucan, MW 40000) is a fluorescent dye, with the molecular weight of 40 kD. TRITC-dextran MW 40000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 40000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 40000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
-
- HY-130666
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Chlorambucyl-proline is a chloroplatinyl amino acid derivative with inhibitory activity against bovine pulmonary vasoconstrictor enzyme. Chlorambucyl-proline reacts with the convertase in a 1:1 ratio, and the removal of its radiolabel indicates that the compound has an irreversible inhibitory effect on the enzyme activity. Chlorambucyl-proline binds to the aspartic acid or glutamic acid side chain of the enzyme by forming an ester bond, resulting in irreversible inactivation of the enzyme. The inactivation rate constant of chlororambucyl-proline increases in the pH range of 5-8, indicating that its effect on the enzyme activity is affected by the pH environment [1].
|
-
- HY-D2254
-
|
|
Fluorescent Dye
|
Others
|
|
CTB probe-1 (probe 1) a lysosome-targeting fluorogenic small-molecule probe for fluorescence imaging in living cells [1].
|
-
- HY-12063
-
PHT-427
1 Publications Verification
|
Akt
Apoptosis
|
Cancer
|
|
PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 μM and 5.2 μM and for Akt and PDPK1, respectively.
|
-
- HY-23430
-
-
- HY-W127770
-
|
|
Fluorescent Dye
|
Others
|
|
Pararosaniline hydrochloride is a pH-responsive basic dye, as a biological stain to track certain proteins. Pararosaniline hydrochloride has been used in the analysis of SO2 and formaldehyde and staining of bacteria or other organisms [1] .
|
-
- HY-23430A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TES sodium is a buffering agent (pKa=7.550 at 25°C). TES sodium is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2 [1] .
|
-
- HY-D0112
-
|
|
Fluorescent Dye
|
Others
|
|
7-Hydroxycoumarin-4-acetic acid, a pH-indicator dye, is covalently bound to bovine serum albumin (BSA) at the positions of reactive amino groups (λmax=326 nm) [1].
|
-
- HY-155754
-
|
|
ATP Synthase
|
Others
|
|
3’-Acetate-ATP, an ATP analogue, is ATP acetylation product with an maxima uv absorption at 259 nm in water at neutral pH. 3’-Acetate-ATP exerts a blocking effect on nucleic acid polymerization [1].
|
-
- HY-45545
-
|
|
Others
|
Others
|
|
Fmoc-gly-gly-ph-gly-nh-ch2-o-ch2cooh can be used to synthesize the ADC Linker, LND1067 [1].
|
-
- HY-B2243H
-
|
Sodium pHospHate monobASIC (USP); Monosodium dihydrogen orthopHospHate (USP); Monosodium pHospHate (USP)
|
Biochemical Assay Reagents
|
Others
|
|
Anhydrous sodium dihydrogen phosphate, meets USP testing specifications is an inorganic salt. It is a chemical compound of sodium with a phosphate counter ion. Anhydrous sodium dihydrogen phosphate, meets USP testing specifications can be used as a pH buffer with other sodium phosphates [1].
|
-
- HY-W016352
-
|
Anilotic acid, 99%
|
Biochemical Assay Reagents
|
Others
|
|
2-Hydroxy-5-nitrobenzoic acid, 99% is used as an HPLC analytical standard, pH indicator, and heavy metal detection agent, and is also used in the study of phenolic compounds oxidation.
|
-
- HY-18749
-
SC79
Maximum Cited Publications
195 Publications Verification
|
Akt
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt [1] .
|
-
- HY-126193
-
|
|
NO Synthase
Apoptosis
|
Cancer
|
|
JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH [1]. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells .
|
-
- HY-158190
-
|
Rose Bengal Medium
|
Bacterial
|
Infection
|
|
Rose-Bengal Chloramphenicol Agar is a selective medium for the enumeration of yeasts and moulds from a wide variety of foodstuffs. The medium has a neutral pH and chloramphenicol is used as a selective agent to suppress the growth of bacteria [1].
|
-
- HY-123633
-
|
|
Glycosidase
|
Others
|
|
4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorogenic substrate for β-glucosidase, utilizes to assay β-glucosidase activity [1]. 4-Methylumbelliferyl β-D-Glucopyranoside releases the highly fluorescent 4-methylumbelliferyl (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively .
|
-
- HY-B2227B
-
|
Lactic acid sodium
|
Bacterial
|
Metabolic Disease
Cancer
|
|
Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis [1]. Lactate (Lactic acid) sodium is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection . Lactate sodium also has antimicrobial activity, which can be used as a food preservative .
|
-
- HY-D0857
-
HEPES
4 Publications Verification
|
Biochemical Assay Reagents
|
Others
|
|
HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis [1] .
|
-
- HY-147104
-
|
|
Fluorescent Dye
|
Others
|
|
Fmoc-Lys(5-FITC)-OH is a marker for polypeptides or proteins. FITC is a fluorescence probe for the labeling of amines. FITC is a pH- and Cu 2+-sensitive fluorescence dye [1] .
|
-
- HY-W040291
-
|
|
Fluorescent Dye
|
Cancer
|
|
7-Hydroxy-4-methylcoumarin-3-acetic acid, SE is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. It is widely used for preparing bioconjugates of blue fluorescence.
|
-
- HY-131510
-
|
SNARF-DE
|
Fluorescent Dye
|
Others
|
|
Chromoionophore XIII (SNARF-DE) is a pH senor that enables excitation with red light. Chromoionophore XIII functionality renders the indicator molecule lipophilic and water-insoluble but also prevents lactonization of the dye in an apolar environment [1].
|
-
- HY-W440995
-
|
|
Liposome
|
Cancer
|
|
DOPE-PEG-Mal (MW 2000) is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. It is also reactive with thiol at pH 6.5 tp 7.5 to form a stable thioether bond.
|
-
- HY-138547
-
|
Diaminopropanoltetraacetic acid
|
Biochemical Assay Reagents
|
Others
|
|
DHPTA (compound 3) can directly combine with lanthanide elements (Tb 3+, Ho 3+, Lu 3+) to form a strong chelating effect，in aqueous solution with a pH of 2.0-7.0 [1].
|
-
- HY-145391
-
|
|
Influenza Virus
|
Infection
|
|
Triperiden is an inhibitor of influenza virus multiplication. Triperiden targets the haemagglutinin of fowl plague virus (FPV) for antiviral activity and acts by inhibiting the conformational change in the haemagglutinin at acid pH. Triperiden is also anticholinergic anti-parkinsonism agent [1].
|
-
- HY-D1082
-
|
|
Fluorescent Dye
|
Others
|
|
5-DTAF is a isomeric fluorescein derivative that directly react with polysaccharides and other alcohols in aqueous solution at pH ＞ 9. The maximum of the 5-DTAF emission profile is at a wavelength of 518 nm after excitation at 488 nm [1].
|
-
- HY-D0859S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
MOPS-d15 is the deuterium labeled MOPS[1]. MOPS is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media[2][3].
|
-
- HY-167003
-
|
|
Liposome
|
Others
|
|
L16 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. L16 can be used in the preparation of liposomes [1].
|
-
- HY-167004
-
|
|
Liposome
|
Others
|
|
IAJD93 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD93 can be used in the preparation of liposomes [1].
|
-
- HY-167004A
-
|
|
Liposome
|
Others
|
|
IAJD249 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD249 can be used in the preparation of liposomes [1].
|
-
- HY-W303135
-
|
|
Biochemical Assay Reagents
|
Others
|
|
EMPO is a free radical scavenger. EMPO is stable in phosphate buffers at physiological pH, its superoxide spin adducts are more durable and no hydroxyl adducts are produced when decaying. EMPO can be used in the study of free radicals [1].
|
-
- HY-P0224
-
|
fMLP; N-Formyl-MLF
|
TNF Receptor
|
Inflammation/Immunology
|
|
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.
|
-
- HY-101677
-
|
|
Drug Metabolite
|
Infection
|
|
cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin [1] .
|
-
- HY-141475
-
|
|
Endogenous Metabolite
|
Others
|
|
Acetoacetyl coenzyme A sodium is a central endogenous metabolite. The Km at pH 7.5 for Acetoacetyl coenzyme A sodium is 1.10 mM. Acetoacetyl coenzyme A sodium can be used for the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB) [1] .
|
-
- HY-P99853
-
|
CR6261
|
Influenza Virus
|
Infection
|
|
Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus [1].
|
-
- HY-116121
-
|
|
Biochemical Assay Reagents
|
Others
|
|
S-Nitrosohomocysteine is a compound generated by the reaction of homocysteine and nitrous acid. It has the activity of quantitative formation under different pH conditions and its stability is affected by transition metal ions. Its formation involves more powerful nitrosating agents.
|
-
- HY-101277
-
|
PG-1016548; AKB-6548
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
|
Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor [1]. Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo [1] .
|
-
- HY-129457
-
FINO2
4 Publications Verification
|
Ferroptosis
|
Cancer
|
|
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation [1].
|
-
- HY-D1593
-
|
|
Fluorescent Dye
|
Others
|
|
BODIPY TMR-X alkyne, an orange-fluorescent dye, is an alkyne modified BODIPY TMR-X. BODIPY TMR-X alkyne can react with azides by the copper-catalyzed click reaction. BODIPY TMR-X alkyne is not sensitive to pH.
|
-
- HY-P2863
-
|
DNase II
|
Endonuclease
|
Others
|
|
Deoxyribonuclease II (DNase II) is an endonuclease that hydrolyzes the phosphodiester bonds of deoxyribonucleotides in native and denatured DNA, producing 3' phosphate and 5'-hydroxyl termini. Deoxyribonuclease II works best at acidic pH and is commonly used in biochemical research [1].
|
-
- HY-116284A
-
|
Methyl β-D-glucoside hemihydrate
|
Others
|
Others
|
|
Methyl β-D-glucopyranoside (Methyl β-D-glucoside) hemihydrate is a hemihydrate compound. Methyl β-D-glucopyranoside hemihydrate less reactive at higher PH. The formation of Methyl β-D-glucopyranoside hemihydrate is stereospecific [1] .
|
-
- HY-167002
-
|
|
Liposome
|
Others
|
|
RM 137-15 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. RM 137-15 can be used in the preparation of liposomes [1].
|
-
- HY-167011
-
|
|
Liposome
|
Others
|
|
Al-28 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. Al-28 can be used in the preparation of liposomes [1].
|
-
- HY-167015
-
|
|
Liposome
|
Others
|
|
1O14 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 1O14 can be used in the preparation of liposomes [1].
|
-
- HY-138540
-
|
N-Dodecylimidazole
|
Fungal
|
Cancer
|
|
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity [1] .
|
-
- HY-125374A
-
|
XRP9881 dihydrate
|
Microtubule/Tubulin
|
Cancer
|
|
Larotaxel (dihydrate) (XRP9881 (dihydrate)), a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors [1].
|
-
- HY-W110798
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bromophenol blue indicator (3.0-4.6) is a synthetic dye commonly used as an acid-base indicator with a transition range of pH 3.0-4.6. Bromophenol blue indicator (3.0-4.6) is water soluble and changes color from yellow to blue as the pH of the solution changes from acidic to basic. Its unique chemical properties make it an important ingredient in a variety of scientific applications, especially in biochemistry and molecular biology. In addition, it can be used as a stain in microbiology and histology. However, Bromophenol blue indicator (3.0-4.6) has potential irritating and staining properties.
|
-
- HY-B2227BR
-
|
|
Bacterial
|
Metabolic Disease
Cancer
|
|
Lactate (sodium) (Standard) is the analytical standard of Lactate (sodium). This product is intended for research and analytical applications. Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis [1]. Lactate (Lactic acid) sodium is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection [4] . Lactate sodium also has antimicrobial activity, which can be used as a food preservative .
|
-
- HY-Y0537J
-
-
- HY-148610
-
|
|
Others
|
Metabolic Disease
|
|
LDH-IN-2, a salicylic acid derivative, is an inhibitor of glycolate oxidase (GO). LDH-IN-2 decreases oxalate output in hyperoxaluric hepatocytes. LDH-IN-2 can be used for research of primary hyperoxaluria type 1 (PH1) [1].
|
-
- HY-D0860
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tricine is widely used as a buffer in protein electrophoresis, nucleic acid analysis, and immunology, which can help adjust pH and stabilize chemical reactions. In addition, the compound can also be used in research in certain medical fields, such as in antibody detection and drug screening.
|
-
- HY-132606
-
|
DCR-pHXC
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
|
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate [1] .
|
-
- HY-139305
-
|
|
Liposome
|
Cancer
|
|
CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response [1] .
|
-
- HY-W803862
-
|
|
Biochemical Assay Reagents
|
|
|
Tripotassium citrate is a compound containing potassium and citrate ions that has activity as a buffer, able to maintain a stable pH required for many enzymatic reactions and biochemical processes. Tripotassium citrate can be used as a buffer in enzyme assays to ensure the validity of experimental conditions.
|
-
- HY-132613
-
|
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
|
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) [1] .
|
-
- HY-Y1242
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism [1] .
|
-
- HY-P4773
-
|
|
HSV
|
Infection
|
|
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (kcat/Km) at pH 7.5 for cleavage is 5.2 M -1 s -1 [1].
|
-
- HY-17608R
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
|
Daprodustat (Standard) is the analytical standard of Daprodustat. This product is intended for research and analytical applications. Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
|
-
- HY-100045
-
|
4-NitropHenylpHospHorylcholine; 4-NitropHenylpHospHorylcholine; O-(4-NitropHenylpHospHoryl)choline
|
Endogenous Metabolite
|
Metabolic Disease
|
|
p-Nitrophenyl phosphorylcholine (4-Nitrophenylphosphorylcholine) is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. Hydrolysis of p-nitrophenylphosphorylcholine by PLC results in the liberation of p-nitrophenol, which can be measured at 405 nm at pH 7.2-7.5.
|
-
- HY-D0952
-
|
|
Parasite
|
Others
|
|
Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays [1] .
|
-
- HY-15529
-
S0859
1 Publications Verification
|
Na+/HCO3- Cotransporter
|
Cardiovascular Disease
|
|
S0859 is a selective, high-affinity generic Na +/HCO3 - transporter (NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM).
|
-
- HY-15369
-
|
|
Akt
Apoptosis
|
Cancer
|
|
FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis [1] .
|
-
- HY-D0873
-
|
EPPS
|
Amyloid-β
|
Neurological Disease
|
|
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier [1].
|
-
- HY-D0877
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pKa value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH) [1] .
|
-
- HY-114174
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing [1].
|
-
- HY-W250110
-
|
|
Biochemical Assay Reagents
|
Infection
Others
|
|
Polyethylenimine (PEI) branched is a organic macromolecule with high cationic-charge-density potential. PEI can ensnare DNA as well as attach to cell membrane, PEI also retains a substantial buffering capacity at virtually any pH. PEI is widely used as transfection reagent [1].
|
-
- HY-D1549
-
|
|
Fluorescent Dye
|
Others
|
|
o-Pah is a BODIPY derivative with an -NH2 and -OH substituted meso-Ph group. o-Pah exhibits metal-induced J-aggregation in the presence of Cu 2+ and a specific fluorescence enhancement for Hg 2+ (Ex/Em=483/(495-600) nM) [1].
|
-
- HY-23430S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
TES-d15 is the deuterium labeled TES[1]. TES is a buffering agent (pKa=7.550 at 25°C). TES is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2[2][3].
|
-
- HY-P4389
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
(Asp28)-Glucagon (1-29) (human, rat, porcine) is an optimized structure of glucagon, the 28th position is replaced by aspartic acid (Asp) which significantly increases the aqueous solubility of glucagon in a physiological pH buffer, has the same activity as glucagon [1].
|
-
- HY-103300
-
|
|
Endogenous Metabolite
|
Infection
|
|
NPE-caged-proton is a reagent that releases protons under UV light and has the activity of activating the fusion protein GP64 under weak acidic conditions. NPE-caged-proton can promote the binding of enveloped viruses to liposome membranes with acidic phospholipids in an environment of pH 4.0 to 5.5, thereby initiating membrane fusion. The ultraviolet unblocking effect of NPE-caged-proton can lower the environmental pH, thereby triggering the process of viral membrane fusion. When studying the interaction between viruses and cell membranes, NPE-caged-proton provides a valuable tool for revealing the subtle behaviors of viruses in different chemical and biochemical environments [1].
|
-
- HY-128945
-
|
|
ADC Linker
|
Inflammation/Immunology
Cancer
|
|
CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker [1].
|
-
- HY-130027
-
HKOCl-4
1 Publications Verification
BXY2142
|
Fluorescent Dye
|
Others
|
|
HKOCl-4 (BXY2142) is a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid with excellent sensitivity and selectivity [1]. HKOCl-4 has longer absorption wavelength and better pH stability compared with fluorescein-based probes. Ex: 530 nm; Em 557 nm.
|
-
- HY-P2818
-
|
Apase
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation [1] .
|
-
- HY-110257
-
|
|
Fluorescent Dye
|
Others
|
|
BODIPY FL-X,SE is a fluorescent greendye for the labeling of amine, shows a high fluorescence quantum yield and is relatively insensitive to pH change. BODIPY FL-X,SE can be used as an alternative for FAM, Cy2 or FITC. λabs: 504 nm; λem:510 nm [1].
|
-
- HY-114352
-
|
|
Fluorescent Dye
|
Others
|
|
BODIPY FL-X is a green-fluorescent dye. BODIPY FL-X has the succinimidyl ester covalently coupled to proteins. BODIPY FL-X has high fluorescence quantum yield and is relatively insensitive to pH change. (λex=504 nm, λem=510 nm) [1] .
|
-
- HY-D1676
-
|
|
Phosphatase
|
Others
|
|
Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum [1] .
|
-
- HY-D0869S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].
|
-
- HY-P10294
-
|
|
Amyloid-β
|
Others
|
|
Oligopeptide P11-4 is an α-peptide that can be self-assembled into β-sheet amyloids with a hydrogel appearance at low pH. Oligopeptide P11-4 can be used in biomimetic mineralization, enamel regeneration and oral care agent [1].
|
-
- HY-W923198
-
|
Methacryloyloxy fluorescein
|
Fluorescent Dye
|
Others
|
|
Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-sensitive dye featuring a fluorescent monomer, characterized by an excitation spectrum at 490 nm and an emission spectrum at 520 nm. With fluorescein serving as an indicator that possesses minimal negative charges, it exhibits properties such as biocompatibility, non-toxicity, and excellent dispersion in aqueous solutions.
|
-
- HY-D0858
-
MES
1 Publications Verification
2-MorpHolinoethanesulpHonic acid
|
Biochemical Assay Reagents
|
Others
|
|
MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
-
- HY-W151206
-
|
|
Fluorescent Dye
|
Others
|
|
Hydroxy naphthol blue disodium, an azo dye, is a metal indicator for calcium and a colorimetric reagent for alkaline earth metal ions ( λmax = 650 nm). In the pH range between 12 and 13, the solution of the indicator is reddish pink in the presence of calcium ion and to deep blue in the presence of disodium EDTA [1].
|
-
- HY-D0858A
-
|
2-MorpHolinoethanesulpHonic acid monohydrate
|
Biochemical Assay Reagents
|
Others
|
|
MES (2-Morpholinoethanesulphonic acid) monohydrate is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES monohydrate is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
-
- HY-142981
-
|
DODA
|
Liposome
|
Others
|
|
Dioctadecylamine (DODA) is a secondary amine that has been shown to self-organize in plate-like structures in aqueous solution. Dioctadecylamine exhibits sufficiently hydrophobic properties of nanoparticles and good dispersibility in nonpolar solvent. Dioctadecylamine does not form a monolayer above pH 3.9 [1] .
|
-
- HY-D0858E
-
|
2-MorpHolinoethanesulpHonic acid potassium
|
Biochemical Assay Reagents
|
Others
|
|
MES (2-Morpholinoethanesulphonic acid) potassium is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES potassium is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
-
- HY-D0858C
-
|
2-MorpHolinoethanesulpHonic acid hydrate
|
Biochemical Assay Reagents
|
Others
|
|
MES (2-Morpholinoethanesulphonic acid) hydrate is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES hydrate is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
-
- HY-E70325
-
|
|
Endogenous Metabolite
|
Others
|
|
Maltogenic amylase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70331
-
|
|
Endogenous Metabolite
|
Others
|
|
Acid Stable Protease is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70335
-
|
|
Endogenous Metabolite
|
Others
|
|
Colipase, Porcine is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70336
-
|
|
Endogenous Metabolite
|
Others
|
|
Peroxidase, Lignin is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70338
-
|
|
Endogenous Metabolite
|
Others
|
|
Ketoamine oxidase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70345
-
|
|
Endogenous Metabolite
|
Others
|
|
Homocysteine methyltransferase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70354
-
|
|
Endogenous Metabolite
|
Others
|
|
Protease for flavors is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-121256
-
|
|
Thymidylate Synthase
Antifolate
Dihydrofolate reductase (DHFR)
|
Others
|
|
Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents [1] .
|
-
- HY-167545
-
|
POPE
|
Liposome
Biochemical Assay Reagents
|
Others
|
|
1-Palmitoyl-2-oleoylphosphatidylethanolamine (POPE) is a PE-based synthetic phospholipid that can intercalate with other amphiphilic molecules to form stable bilayers at physiological pH. 1-Palmitoyl-2-oleoylphosphatidylethanolamine can be used in drug delivery research [1].
|
-
- HY-14179
-
PPQ-102
3 Publications Verification
CFTR Inhibitor
|
CFTR
|
Others
|
|
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease [1].
|
-
- HY-149035
-
|
|
Others
|
Cancer
|
|
PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model [1].
|
-
- HY-D0857S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].
|
-
- HY-P4522
-
|
|
Endogenous Metabolite
|
Others
|
|
Bz-Ala-Arg is a dipeptide. Bz-Ala-Arg is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg can be used to screen competitive inhibitors of these two enzymes [1].
|
-
- HY-E70326
-
|
|
Endogenous Metabolite
|
Others
|
|
Acid Protease, Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70327
-
|
|
Endogenous Metabolite
|
Others
|
|
Aspartate Aminotransferase, Human is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70332
-
|
|
Endogenous Metabolite
|
Others
|
|
Lipase, Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70337
-
|
|
Endogenous Metabolite
|
Others
|
|
Heparanase 1, Human is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70340
-
|
|
Endogenous Metabolite
|
Others
|
|
Lipoamide dehydrogenase, porcine is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70346
-
|
|
Endogenous Metabolite
|
Others
|
|
S-Adenosylmethionine synthetase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70347
-
|
|
Endogenous Metabolite
|
Others
|
|
Tn5 Transposase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-D2379A
-
|
|
Fluorescent Dye
|
|
|
closed-HMRG is HMRG with closed spirocyclic structure. Ac-HMRG, an acetylated derivative of Hydroxymethyl rhodamine green, exists as a closed spirocyclic structure in aqueous solution at physiological pH, whereas HMRG itself takes an open nonspirocyclic structure. Ac-HMRG is colorless and nonfluorescent and HMRG is strongly fluorescent [1].
|
-
- HY-D0902
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Triethanolamine borate is a compound belonging to the class of borates. It is commonly used in the manufacture of personal care and cosmetics as an emulsifier, pH adjuster and buffer. Triethanolamine borate helps stabilize and thicken products such as lotions and creams and can improve their overall texture. It is also used in industrial applications such as the production of lubricants and metalworking fluids.
|
-
- HY-167735
-
|
Bisdequalinium diacetate
|
Others
|
Infection
|
|
Salvizol (Bisdequalinium diacetate) is a chemotherapeutic agent with a broad spectrum of bactericidal activity, effective in the apical third of root canals. Salvizol possesses the ability to dissolve organic dentin matrix, facilitating mineralization and tubule exposure. Salvizol maintains a neutral pH, ensuring biological compatibility while exhibiting significant cleansing potency.
|
-
- HY-128945A
-
|
|
ADC Linker
|
Inflammation/Immunology
Cancer
|
|
CL2A TFA is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A TFA is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker [1].
|
-
- HY-P10742
-
|
|
Peptide-Drug Conjugates (PDCs)
Topoisomerase
|
Cancer
|
|
CBX-12 is a PDC (peptide drug conjugate) that targets tumors in an antigen-independent manner and exhibits antitumor activity. CBX-12 consists of a pH-sensitive peptide (pHLIP), a self-immolating linker, and a topoisomerase 1 (TOP1) inhibitor Exatecan (HY-13631) [1].
|
-
- HY-D0031
-
|
APTS
|
Fluorescent Dye
|
Others
|
|
8-Aminopyrene-1,3,6-trisulfonic acid trisodium is a water-soluble anionic fluorescent dye. The fluorescence intensity of 8-Aminopyrene-1,3,6-trisulfonic acid trisodium remains nearly constant over a pH range from 4 to 10 [1].
|
-
- HY-149036
-
|
|
Ferroptosis
Endogenous Metabolite
Reactive Oxygen Species
|
Cancer
|
|
PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity [1].
|
-
- HY-D0858D
-
|
2-MorpHolinoethanesulpHonic acid hemisodium
|
Biochemical Assay Reagents
|
Others
|
|
MES (2-Morpholinoethanesulphonic acid) hemisodium is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES hemisodium is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
-
- HY-E70328
-
|
|
Endogenous Metabolite
|
Others
|
|
Alkalophilic Proteinase, Streptomyces sp is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70330
-
|
|
Endogenous Metabolite
|
Others
|
|
Neutral Proteinase, Bacillus sp. is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70343
-
|
|
Endogenous Metabolite
|
Others
|
|
Human leukocyte esterase (unsonicated) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70344
-
|
|
Endogenous Metabolite
|
Others
|
|
Cystathionine γ-lyase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70349
-
|
|
Endogenous Metabolite
|
Others
|
|
Betaine homocysteine S-methyltransferase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70351
-
|
|
Endogenous Metabolite
|
Others
|
|
Trypsin-Chymotrypsin 1:1 is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70352
-
|
|
Endogenous Metabolite
|
Others
|
|
Trypsin-Chymotrypsin 1:250 is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70353
-
|
|
Endogenous Metabolite
|
Others
|
|
Trypsin-Chymotrypsin 6:1 is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-D0234
-
|
ortho-CresolpHthalein
|
Endogenous Metabolite
|
Others
|
|
o-Cresolphthalein (ortho-Cresolphthalein) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-W702290
-
|
|
Others
|
Others
|
|
2-Methyldecanenitrile is a compound with biological activity for fragrance applications. 2-Methyldecanenitrile exhibits a rich peach aroma with frankincense undertones in perfume compositions. 2-Methyldecanenitrile is stable across the entire pH range, enabling it to create a stable fruity effect at low concentrations in any application [1].
|
-
- HY-D0861
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages [1] .
|
-
- HY-D0876
-
|
|
Biochemical Assay Reagents
|
Others
|
|
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC50 value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 [1] .
|
-
- HY-D1654
-
|
|
Fluorescent Dye
|
Others
|
|
BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.
|
-
- HY-W176012
-
|
|
Others
|
Metabolic Disease
|
|
Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC50 of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1) [1].
|
-
- HY-P99681
-
|
IMMU 130; hMN-14-SN-38
|
Antibody-Drug Conjugates (ADCs)
|
Cancer
|
|
Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer [1] .
|
-
- HY-Y0836S1
-
|
Diethyl Butanedioate-d4
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Diethyl succinate-d4 is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
|
-
- HY-E70320
-
|
Immobilized cefadroxil acylase
|
Endogenous Metabolite
|
Others
|
|
AMK618 (Immobilized cefadroxil acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70321
-
|
Immobilized cefradine acylase
|
Endogenous Metabolite
|
Others
|
|
AMK518 (Immobilized cefradine acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70322
-
|
Immobilized cefaclor acylase
|
Endogenous Metabolite
|
Others
|
|
AMK328 (Immobilized cefaclor acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70323
-
|
Immobilized cepHalexin acylase
|
Endogenous Metabolite
|
Others
|
|
AMK318 (Immobilized cephalexin acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70324
-
|
Immobilized amoxicillin acylase
|
Endogenous Metabolite
|
Others
|
|
AMK218 (Immobilized amoxicillin acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70329
-
|
|
Endogenous Metabolite
|
Others
|
|
P-Hydroxybenzoate hydroxylase, native microorganism is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70339
-
|
|
Endogenous Metabolite
|
Others
|
|
Phenylethanolamine N-methyl transferase, bovine is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70341
-
|
|
Endogenous Metabolite
|
Others
|
|
Histamine N-methyl transferase, rat is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70350
-
|
|
Endogenous Metabolite
|
Others
|
|
Ribonuclease T2, Aspergillus oryzae is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-111549
-
|
|
Others
|
Cancer
|
|
Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity [1].
|
-
- HY-108717
-
|
Protease K
|
Ser/Thr Protease
|
Others
|
|
Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection [1] .
|
-
- HY-145413
-
|
|
Glutathione S-transferase
|
Cancer
|
|
BRD2889 is an analog of the alkaloid piperlongumine. BRD2889 is a robust modulator of the GSTP1-ISCU axis in pulmonary hypertension (PH) [1]. BRD2889 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-151544
-
|
|
Fluorescent Dye
|
Others
|
|
PNE-Lyso is a activatable fluorescent probe. PNE-Lyso can be used to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals. PNE-Lyso can be used to distinguish apoptosis from necrosis through visualizing lysosome morphology. PNE-Lyso is capable of investigating the agent-induced cell death process [1].
|
-
- HY-15351
-
|
NSC 675186
|
HIV
|
Infection
|
|
UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an IC50 value of 5 nM. UC-781 is stable under low PH or various temperatures conditions. UC-781 has antiviral activity and resistance [1] .
|
-
- HY-Y0836S
-
|
1,4-Diethyl butanedioate-1,2,3,4-13C4
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Diethyl succinate- 13C4 is the 13C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
|
-
- HY-N8502
-
|
|
Fluorescent Dye
|
Cancer
|
|
Urdamycin A (Compound 3b) is an angucycline antibiotic that can be isolated from Streptomyces fradiae. Urdamycin A is an orange indicator with a change of the color to ultramarine blue at pH 7.7. Urdamycin A has anticancer activity with IC50s of 2.4 and 0.55 μg/mL in proliferation and stem cell assays, respectively [1].
|
-
- HY-E70283
-
|
rEGCase II assisted by Activator II
|
Endogenous Metabolite
|
Others
|
|
Recombinant endoglycoceramidase II assisted by activator II is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70315
-
|
Fungal Endo- and Exo- chitosanases
|
Endogenous Metabolite
|
Others
|
|
Chimax-G (Fungal Endo- and Exo- chitosanases) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70334
-
|
|
Endogenous Metabolite
|
Others
|
|
Carboxypeptidase Y, Baker's yeast (S. cerevisiae) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-P4522A
-
|
|
Endogenous Metabolite
|
Others
|
|
Bz-Ala-Arg TFA is a dipeptide. Bz-Ala-Arg TFA is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg TFA can be used to screen competitive inhibitors of these two enzymes [1].
|
-
- HY-159129
-
|
|
Ser/Thr Protease
|
Cancer
|
|
hCAXII-IN-10 (Compound 18b) is a dual inhibitor of human carbonic anhydrase isoform XII (hCAXII) and cathepsin B, with a Ki value of 2.2 nM. hCAXII-IN-10 can inhibit the role of hCAXII in providing tumors with a pH microenvironment conducive to tumor growth, and is expected to be used in the study of tumor diseases [1].
|
-
- HY-15940
-
|
5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers
|
Fluorescent Dye
|
Cancer
|
|
5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo [1] .
|
-
- HY-111550
-
|
|
Ras
MDM-2/p53
|
Cancer
|
|
Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells [1].
|
-
- HY-D1156
-
|
|
Reactive Oxygen Species
Fluorescent Dye
|
Others
|
HKSOX-1m (5/6-mixture) is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells [1].
|
-
- HY-D1156A
-
|
|
Reactive Oxygen Species
Fluorescent Dye
|
Others
|
HKSOX-1m (5/6-mixture) hydrobromide is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells [1].
|
-
- HY-D0861A
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages [1] .
|
-
- HY-D1688
-
|
|
Fluorescent Dye
|
Others
|
|
Flubida-2 is a cell permeable dye which can be hydrolyzed to Fubi-2 by endoesterases in cells (after hydrolysis, Ex=492 nm, Em=517 nm). Flubida-2 can be used to detect pH at a specific site in a cell organelle by directing the probe to where avidin fusion proteins are located [1].
|
-
- HY-150097
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Recombinant Human Serum Albumin (rHSA) is an active compound and possesses an identical conformation to plasma derived HSA. Recombinant Human Serum Albumin (rHSA) has no difference between rHSA and plasma derived HSA. The main physiological function of Recombinant Human Serum Albumin (rHSA) is to regulate plasma pH and maintain plasma osmotic pressure [1].
|
-
- HY-151712
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent containing a methyltetrazine group. Sulfo-Cy5-Methyltetrazine acts as a fluorophore linker for trans-cyclooctene-based labeling. Sulfo-Cy5-Methyltetrazine shows good stability at physiological pH and is also highly reactive towards cyclooctene.
|
-
- HY-108798
-
|
|
VEGFR
|
Cardiovascular Disease
Cancer
|
|
Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases [1] .
|
-
- HY-E70312
-
|
Candida antarctica lipase
|
Endogenous Metabolite
|
Others
|
|
CalB-10Xup (Candida antarctica lipase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70333
-
|
AR2000
|
Endogenous Metabolite
|
Others
|
|
Rapidase Revelation Aroma (AR2000), Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-E70348
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Methionine γ-lyase, pseudomonas putida is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
-
- HY-137798
-
|
|
Fluorescent Dye
|
Others
|
|
Chromozym PL is a chromogenic substrate for plasmin, and the enzymatic reaction can be carried out in 0.1mL Tris-HCl buffer (50 mM, pH 7.8). 100 μM Chromozym PL was dissolved and prepared. After adding the hydrolase, the generation of p-nitroaniline (pNA) at 405 nm was continuously observed, and the hydrolysis products were calculated [1].
|
-
- HY-167012
-
|
|
Liposome
|
Others
|
|
306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes [1].
|
-
- HY-162985
-
|
|
CDK
|
Cancer
|
|
JHD205 is a CDK4/6 inhibitor that induces apoptosis and DNA damage. JHD205 inhibits DNA repair by upregulating Caspase3 and p-H2AX. JHD205 has superior potency to Abemaciclib (HY-16297A) in a xenograft chick embryo breast cancer model. [1].
|
-
- HY-B1422S
-
|
Aminacrine-13C6
|
Bacterial
HIV
Isotope-Labeled Compounds
|
Infection
|
|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections [1] .
|
-
- HY-132588
-
|
ALN-G01
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
|
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) [1] .
|
-
- HY-113314
-
|
|
Endogenous Metabolite
|
Cancer
|
|
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pKa of AFMK at physiological pH is 8.7. Antioxidant capacity [1] . AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway .
|
-
- HY-124473
-
|
NapHthafluorescein
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
|
Naphthofluorescein inhibits the interaction between HIF-1 and Mint3.
Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo [1]. Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging .
|
-
- HY-147087
-
|
|
Liposome
|
Cancer
|
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo [1].
|
-
- HY-B2217D
-
|
|
Bacterial
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
Calcium hydroxide, ACS, 95% has high bactericidal activity and high pH. Calcium hydroxide, ACS, 95% has ability to induce hard tissue formation. Calcium hydroxide, ACS, 95% can dissociate into calcium (Ca) and hydroxyl ions (OH). Calcium hydroxide, ACS, 95% has the potential for intra-canal medicament research [1].
|
-
- HY-W747868
-
|
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
|
Molidustat sodium is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat sodium can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat sodium can be utilized in the research of renal anemia [1] .
|
-
- HY-P2818C
-
|
Apase, microorganism
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Alkaline phosphatase, microorganism is a membrane-bound glycoprotein. It can hydrolyze monophosphate esters at alkaline pH, releasing inorganic phosphate. Alkaline phosphatase, microorganism is also capable of dephosphorylating proteins, and the balance between protein phosphorylation and dephosphorylation plays a key role in regulating various cellular functions. Alkaline phosphatase, microorganism can regulate cell proliferation and differentiation [1].
|
-
- HY-133847
-
|
Laurylamidopropyldimethylamine oxide
|
Endogenous Metabolite
|
Others
|
|
LAPAO (Laurylamidopropyldimethylamine oxide) is an amphoteric surfactant with good biocompatibility and surface activity. LAPAO can be used as a detergent and foam enhancer for personal care and household cleaning products. LAPAO is stable at different pH values and can effectively remove dirt and grease. LAPAO also has a conditioning effect and is suitable for use in skin care and hair care products [1].
|
-
- HY-D0858S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
MES-d13 is the deuterium labeled MES. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
-
- HY-12654
-
|
BAY 85-3934
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
|
Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia [1] .
|
-
- HY-128144
-
|
|
Lipase
|
Metabolic Disease
|
|
Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells [1] .
|
-
- HY-108460
-
|
|
TRP Channel
|
Neurological Disease
|
|
A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration [1].
|
-
- HY-151713
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cy3-Methyltetrazine (figure 7 compound 5) is a click chemistry reagent containing methyltetrazine and a water-soluble dye. Sulfo-Cy3-Methyltetrazine shows good stability at physiological pH. Sulfo-Cy3-Methyltetrazine can be coupled to trans-cyclooctene and is also highly reactive towards cyclooctene [1].
|
-
- HY-P5780
-
|
|
Sodium Channel
|
Neurological Disease
|
|
π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC50 of 1-2 nM and potentiates ASIC1b with an EC50 of 46.5 nM [1].
|
-
- HY-D2083
-
|
|
Fluorescent Dye
|
Cancer
|
|
BODIPY 540 (purity>98%) is a BODIPY dye.BODIPY dye is a small molecule dye with strong UV absorption ability.Its fluorescence peak is relatively sharp, its quantum yield is high, and it is relatively insensitive to the polarity and pH value of the environment.BODIPY 540 (purity>98%) has a purity higher than 98% and is suitable for cell experiments [1].
|
-
- HY-P5174
-
|
|
Sodium Channel
|
Neurological Disease
|
|
MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC50 values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation [1].
|
-
- HY-W440884
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-Ald, MW 3400 is a self-assemble polyPEG which spontaneously forms lipid bilayer in water. The polymer can be used to prepare nanoparticles or liposomse as a targeted drug carrier, such as mRNA vaccine. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
|
-
- HY-D2379
-
|
|
Fluorescent Dye
|
Endocrinology
Cancer
|
HMRG is a type of hydroxymethyl rhodamine green fluorescent scaffold, featuring an open non-cyclic structure. HMRG can produce significant dynamic fluorescence changes through a one-step enzymatic reaction at physiological pH, which is useful for developing various probes. Fluorescent probes based on HMRG can be used for fluorescence detection of diseases such as tumors and diabetic nephropathy [1].
|
-
- HY-116182
-
|
|
Influenza Virus
|
Infection
|
|
RO5487624, an analogue of RO5464466 (HY-120690), is an orally active hemagglutinin (HA) inhibitor of influenza H1N1 viruses that abolishes influenza virus fusion by blocking HA conformational changes in low pH environments. RO5487624 displays a protective effect on mice that are lethally challenged with influenza H1N1 virus [1].
|
-
- HY-D0858AR
-
|
|
Biochemical Assay Reagents
|
Others
|
|
MES (monohydrate) (Standard) is the analytical standard of MES (monohydrate). This product is intended for research and analytical applications. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
-
- HY-15295
-
|
TAK-438
|
Proton Pump
|
Metabolic Disease
Cancer
|
|
Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease [1] .
|
-
- HY-D0914
-
|
FD&C Green No. 3; Food green 3; C.I. 42053
|
Fluorescent Dye
|
Others
|
|
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system [1].
|
-
- HY-128590
-
PHT-7.3
1 Publications Verification
|
Ras
|
Cancer
|
|
PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity [1].
|
-
- HY-P4108
-
|
|
Influenza Virus
|
Infection
|
|
TAT-HA2 Fusion Peptide is a peptide-based delivery agent that combines the pH-sensitive HA2 fusion peptide from Influenza and the cell-penetrating peptide TAT from HIV. TAT-HA2 Fusion Peptide is a transactivator of transcription and hemaglutanin for endosomal release. TAT-HA2 Fusion Peptide enhances cellular uptake of macromolecules [1].
|
-
- HY-D2324
-
|
|
Fluorescent Dye
|
Others
|
|
EE-Flipper 33 is a Flipper probe designed to evaluate the mechanism of early endocytosis. EE-Flipper has a pKa value of 10.6 and is capable of tracking approximately 70% of early endosomes (EE) in live cells. Furthermore, EE-Flipper 33 can also label the Golgi apparatus in live cells with an internal pH ranging from 6.0 to 6.7 [1].
|
-
- HY-146659S
-
|
3-(pHenylthio)-DL-alanine; H-DL-Cys(pH)-OH-d2
|
Isotope-Labeled Compounds
|
Others
|
|
S-Phenyl-DL-cysteine-3,3-d2 is the deuterium labeled S-Phenyl-DL-cysteine-3,3[1].
|
-
- HY-50868
-
|
INNO-406; NS-187
|
Bcr-Abl
Src
Apoptosis
|
Cancer
|
|
Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph + leukemia cells. Bafetinib has antitumor activity [1] .
|
-
- HY-P10228
-
|
|
Fungal
Bacterial
|
Infection
|
|
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner [1].
|
-
- HY-161497
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Thalidomide-benzylamine-Py-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and the Linker Boc-NHCH2-Ph-Py-NH2 (HY-161496). Thalidomide-benzylamine-Py-NH2 is utilized for synthesis of PROTAC molecule XYD190 (HY-161494) [1].
|
-
- HY-W440883
-
|
|
Liposome
|
Others
|
|
DSPE-PEG-Ald, MW 2000 is a phospholipid polyPEG which can self-assemble to form lipid bilayer in aqueous solution. The polymer can be used to prepare liposome as a drug delivery vehicle for administration of drugs or nutrients, such as mRNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
|
-
- HY-101775
-
|
|
Topoisomerase
|
Cardiovascular Disease
Cancer
|
|
9-hydroxyellipticine is an inhibitor of Topo II and RyR, exhibiting high affinity for DNA with a Pka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC50 values of 1.6 μM and 1.2 μM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice [1].
|
-
- HY-W016352R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Hydroxy-5-nitrobenzoic acid, 99% (Standard) is the analytical standard of 2-Hydroxy-5-nitrobenzoic acid, 99%. This product is intended for research and analytical applications. 2-Hydroxy-5-nitrobenzoic acid, 99% is used as an HPLC analytical standard, pH indicator, and heavy metal detection agent, and is also used in the study of phenolic compounds oxidation.
|
-
- HY-D0897
-
|
N-(1-NapHthyl)-3-aminopropanesulfonic acid sodium
|
Biochemical Assay Reagents
|
Others
|
|
3-(1-naphthalenylamino)-1-Propanesulfonic acid sodium salt is a compound belonging to the class of sulfonic acids. It is commonly used in the pharmaceutical industry as a buffer and stabilizer for drugs and other medicines. 3-(1-naphthalenylamino)-1-Propanesulfonic acid sodium salt helps to maintain the pH and stability of the drug, thereby improving the efficacy and shelf life of the drug. It can also be used as a dispersant in the production of nanoparticles and other materials.
|
-
- HY-12914
-
|
|
TRP Channel
|
Neurological Disease
Inflammation/Immunology
|
|
V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP)- and acid (pH 5)-induced currents in rat DRG neurons expressing native TRPV (IC50=423.2 nM for CAP; IC50=180.3 nM for acid). V116517 can be used for the research of pain [1].
|
-
- HY-110077
-
|
|
Akt
Apoptosis
|
Cancer
|
|
API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL) [1] .
|
-
- HY-100007A
-
|
TAK-438 hydrochloride
|
Proton Pump
Bacterial
|
Infection
Endocrinology
Cancer
|
|
Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori [1] .
|
-
- HY-118338
-
|
|
Parasite
|
Infection
|
|
WRR-483 is an analog of K11777, an inhibitor of cruzain, used to inhibit the proliferation of Trypanosoma cruzi in cell culture. WRR-483 can eradicate parasitic infection in an acute Chagas disease mouse model. WRR-483 is an irreversible cysteine protease inhibitor that shows pH-dependent high affinity and potent trypanocidal activity against cruzain and T. cruzi infection, and is expected to inhibit Chagas disease.
|
-
- HY-168022
-
|
|
Aurora Kinase
|
Cancer
|
CAM2602 is an Aurora A-TPX2 interaction inhibitor that has a binding affinity of 19 nM to Aurora A. CAM2602 can inhibit the growth of pancreatic cancer cells. In solid tumor transplant models, CAM2602 can increase the proportion of PH3 positive cells while reducing the proportion of P-Thr288 Aurora A positive cells, thereby inhibiting tumor growth [1].
|
-
- HY-100381
-
|
|
Potassium Channel
NOD-like Receptor (NLR)
Bacterial
Antibiotic
Pyroptosis
Wnt
β-catenin
|
Infection
Cancer
|
|
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC [1] .
|
-
- HY-14818
-
|
R 125489
|
Influenza Virus
|
Infection
|
|
Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively [1].
|
-
- HY-127019
-
|
|
Potassium Channel
NOD-like Receptor (NLR)
Bacterial
Antibiotic
Pyroptosis
Wnt
β-catenin
|
Infection
Cancer
|
|
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC [1] .
|
-
- HY-A0104K
-
|
Hypromellose (Type II,Viscosity:3mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:3mPa.s); Celacol HPM 5000 (Type II,Viscosity:3mPa.s)
|
Biochemical Assay Reagents
|
Others
|
|
HPMC (Type II,Viscosity:3mPa.s) is a derivative of Cellulose (HY-B2221), which forms pH-stable transparent colloidal solution in water. HPMC (Type II,Viscosity:3mPa.s) contains no ionized group, and exhibits good thermoplasticity, viscosity, biocompatibility and biodegradability, that can be used as stabilizer, thickener, and emulsifier in medicine, food, coatings, adhesives and construction industries [1].
|
-
- HY-W931056
-
|
|
TRP Channel
|
Neurological Disease
|
|
AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5)-induced Ca 2+ influx into TRPV1- expressing CHO cell with IC50 of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448)-induced rat model, and exhibits a half-life of 2.4 h in rats [1].
|
-
- HY-15558
-
|
bisBenzimide H 33258; H 33258
|
Fluorescent Dye
|
Cancer
|
|
Hoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15559
-
|
bisBenzimide H 33342; HOE 33342
|
Autophagy
|
Others
|
|
Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15560
-
|
HOE 34580
|
Amyloid-β
|
Neurological Disease
|
|
Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15619
-
|
Nuclear yellow
|
Fluorescent Dye
|
Others
|
|
Hoechst S 769121 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15561
-
|
meta-Hoechst
|
Fluorescent Dye
|
Cancer
|
|
HOE-S 785026 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15562
-
|
|
Fluorescent Dye
|
Others
|
|
HOE 32021 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15622
-
|
|
DNA Stain
|
Cancer
|
|
meta-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15623
-
|
|
DNA Stain
|
Others
|
|
Hoechst 33258 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15626
-
|
|
Fluorescent Dye
|
Others
|
|
ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15627
-
|
|
Fluorescent Dye
|
Others
|
|
Hoechst 33342 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15629
-
|
|
DNA Stain
|
Others
|
|
HOE 32020 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15632
-
|
|
Fluorescent Dye
|
Others
|
|
para-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15559A
-
|
bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride
|
Autophagy
|
Others
|
|
Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-100007
-
|
TAK-438 free base
|
Proton Pump
Bacterial
|
Endocrinology
Cancer
|
|
Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori [1] .
|
-
- HY-15561B
-
|
meta-Hoechst trihydrochloride
|
Fluorescent Dye
|
Others
|
|
HOE-S 785026 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15560B
-
|
HOE 34580 tetrahydrochloride
|
Amyloid-β
|
Neurological Disease
|
|
Hoechst 34580 tetrahydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15558A
-
|
bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride
|
Fluorescent Dye
|
Cancer
|
|
Hoechst 33258 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-Y0836
-
|
Diethyl Butanedioate
|
Biochemical Assay Reagents
Reactive Oxygen Species
|
Metabolic Disease
Inflammation/Immunology
|
|
Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings [1] .
|
-
- HY-106991A
-
|
S-303 dihydrochloride
|
HIV
Bacterial
|
Infection
|
|
Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) [1] .
|
-
- HY-15563
-
|
|
Fluorescent Dye
|
Others
|
|
HOE 33187 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-17507S
-
|
BY1023-d6; SKF96022-d6
|
Isotope-Labeled Compounds
Proton Pump
Autophagy
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Pantoprazole-d6 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
|
-
- HY-17507S1
-
|
BY1023-d3; SKF96022-d3
|
Isotope-Labeled Compounds
Proton Pump
Autophagy
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Pantoprazole-d3 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
|
-
- HY-159125
-
|
|
PD-1/PD-L1
|
Cancer
|
|
PD-1/PD-L1-IN-47 (MolPort-001-742-690) is a PH-selective PD-1/PD-L1 signaling pathway inhibitor with significant affinity for PD-L1 under acidic conditions and lower toxicity. PD-1/PD-L1-IN-47 can be used in the study of tumors [1].
|
-
- HY-W440885
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-Ald, MW 5000 is a phospholipid PEG polymer which can self-assemble spontaneously in water with their hydrophilic heads oriented toward the water (micelles). The polymer can be used to prepare liposome as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
|
-
- HY-15624
-
|
|
DNA Stain
|
Cancer
|
|
Hoechst 33258 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15625
-
|
|
DNA Stain
|
Others
|
|
Hoechst 33258 analog 3 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15628
-
|
|
DNA Stain
|
Others
|
|
Hoechst 33258 analog 5 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15630
-
|
|
Fluorescent Dye
|
Cancer
|
|
Hoechst 33342 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15631
-
|
|
Fluorescent Dye
|
Others
|
|
Hoechst 33258 analog 6 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-15893
-
|
Dimethyloxallyl Glycine
|
HIF/HIF Prolyl-Hydroxylase
Autophagy
|
Cancer
|
|
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo [1]. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal . DMOG induces cell autophagy .
|
-
- HY-15630A
-
|
|
Fluorescent Dye
|
Others
|
|
Hoechst 33342 analog 2 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
-
- HY-128943
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma [1] .
|
-
- HY-143285
-
|
|
Fluorescent Dye
|
Infection
|
|
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate [1].
|
-
- HY-P5704
-
|
|
Bacterial
|
Infection
|
|
K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability [1].
|
-
- HY-17507AR
-
|
BY1023 (sodium) (Standard); SKF96022 (sodium) (Standard)
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Pantoprazole (sodium) (Standard) is the analytical standard of Pantoprazole (sodium). This product is intended for research and analytical applications. Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) [1]. Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-150086
-
|
CF4
|
Fluorescent Dye
|
Others
|
|
Copper Fluor-4 (CF4) is a Cu +-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9×10 −13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission) [1] .
|
-
- HY-E70311
-
|
Thermomyces lanuginosus lipase
|
Endogenous Metabolite
|
Others
|
|
TLL-10X (Thermomyces lanuginosus lipase) is a high-efficiency biocatalyst, a lipase from Thermomyces lanuginosus. TLL-10X can be conjugated to magnetic nanoparticles and coupled to the surface of Fe(3)O(4)-COOH to obtain better temperature resistance and pH resistance. The activity unit (U) of lipase is defined as the amount of enzyme that produces 1 μmol of fatty acid per minute under experimental conditions [1].
|
-
- HY-E70318
-
|
Immobilized Penicillin G acylase
|
Endogenous Metabolite
|
Others
|
|
AMK-GX (Immobilized Penicillin G acylase) is an immobilized penicillin acylase with improved temperature and pH stability. AMK-GX has reusable performance and high recovery rates, retaining much of its original activity after 12 cycles. Among them, AMK-GX can catalyze penicillin G (PG) to generate 6-aminopenicillanic acid (6-APA) and 7-aminodeacetoxycephalosporanic acid, which are key intermediates for β-lactam antibiotics [1].
|
-
- HY-P10329
-
|
|
Fungal
|
Infection
|
|
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 [1].
|
-
- HY-W412175
-
|
ZincpHyrin dihydrochloride
|
Bacterial
|
Infection
|
|
Coproporphyrin III dihydrochloride is a bioactive molecule excreted by nostril- and skin-associated Propionibacterium species that induces aggregation of Staphylococcus aureus (conditions: during early stationary phase growth, low pH: 4-6). Coproporphyrin III dihydrochloride also induces plasma-independent biofilm formation on abiotic surfaces by Staphylococcus aureus. Coproporphyrin III dihydrochloride may be an important mediator of S. aureus accumulation and/or biofilm formation in the nostrils or other sites where Propionibacterium and S. aureus inhabit [1].
|
-
- HY-N2334
-
|
Chenodeoxycholylglycine
|
Endogenous Metabolite
Apoptosis
STAT
BCL6
Interleukin Related
Caspase
|
Metabolic Disease
Cancer
|
|
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) [1] .
|
-
- HY-N2334A
-
|
Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate
|
Endogenous Metabolite
Apoptosis
STAT
BCL6
Interleukin Related
Caspase
|
Metabolic Disease
Cancer
|
|
Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) [1] .
|
-
- HY-15627A
-
|
|
Fluorescent Dye
DNA Stain
|
Others
|
|
Hoechst 33342 analog trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1]. Storage: Keep away from light.
|
-
- HY-158255
-
|
|
Biochemical Assay Reagents
|
Others
|
|
mPEG-PLGA (2000-80000) (LA/GA 50:50) is a copolymer, which consists of hydrophilic mPEG and biodegradable PLGA (molar ratio is 50:50) with a molecular weight of 2000 (mPEG) + 80000 (PLGA). mPEG-PLGA (2000-80000) (LA/GA 50:50) forms nanoparticles or microparticles, which is stable in aqueous solution at different pH values and elevated temperatures as well as in serum. mPEG-PLGA (2000-80000) (LA/GA 50:50) is utilized as carrier material in drug delivery systems [1].
|
-
- HY-14818R
-
|
|
Influenza Virus
|
Infection
|
|
Laninamivir (Standard) is the analytical standard of Laninamivir. This product is intended for research and analytical applications. Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively [1].
|
-
- HY-P2807J
-
|
|
Lactate Dehydrogenase
|
Metabolic Disease
|
L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC50 values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes [1].
|
-
- HY-P2866A
-
|
NAG, Porcine kidney
|
Others
|
Others
|
|
β-N-Acetylhexosaminidase, Porcine kidney is a glycosidase with transglycosylation activity, used to generate health-beneficial human milk oligosaccharides, and it effectively interacts with low molecular weight sugar alcohols (such as glycerol, erythritol, and xylitol). The enzyme exhibits optimal activity at pH 5 and 40 °C, and shows high thermal stability (up to 55°C) when bound to the cell wall. β-N-Acetylhexosaminidase holds promise for applications in the biotransformation of Chitin (HY-126389) and research in the food health sector [1].
|
-
- HY-115312
-
|
|
Na+/K+ ATPase
|
Others
|
|
Ro 18-5364 is an inhibitor of gastric H+/K+ ATPase, which has the effect of inhibiting the activity of the enzyme. Ro 18-5364 has a very strong inhibitory effect on gastric mucosal H+/K+ ATPase, and the inhibitory effect is more significant at low pH. At the same time, there is no selectivity difference between the two enantiomers of H+/K+ ATPase, and its inhibitory effect can be studied and verified by a variety of experimental methods, including inhibition of enzyme activity, proton transport, and studies on its binding.
|
-
- HY-100381R
-
|
|
Potassium Channel
NOD-like Receptor (NLR)
Bacterial
Antibiotic
Pyroptosis
Wnt
β-catenin
|
Infection
Cancer
|
|
Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K +/H + ionophore, promoting K +/H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC [1] .
|
-
- HY-D1106
-
|
|
Fluorescent Dye
|
Cancer
|
|
BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions [1]. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells .
|
-
- HY-W019883
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Dipotassium hydrogen phosphate is a highly water-soluble salt which is often used as a fertilizer, food additive and buffering agent. Dipotassium hydrogen phosphate can be used as an excipient, such as pH regulator, buffer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1] .
|
-
- HY-156514
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
MC-GGFG-AM-(10NH2-11F-Camptothecin) is an antibody drug conjugates (ADC). MC-GGFG-AM-(10NH2-11F-Camptothecin) binds to the anti-TROp-2 antibody sacituzumab via a hydrolysable pH-sensitive linker and has anti-tumor activity. MC-GGFG-AM-(10NH2-11F-Camptothecin) can be used for cancer research [1].
|
-
- HY-153220A
-
|
|
PROTACs
Btk
|
Inflammation/Immunology
Cancer
|
|
(R)-NX-2127 ((R)-compound 28) is an isomer of the BTK PROTAC degrader NX-2127 (HY-153220) [1]. (R)-NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).
|
-
- HY-100007R
-
|
TAK-438 (Standard)
|
Proton Pump
Bacterial
|
Endocrinology
|
|
Vonoprazan (Standard) is the analytical standard of Vonoprazan. This product is intended for research and analytical applications. Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori [1] .
|
-
- HY-Y0836R
-
|
|
Biochemical Assay Reagents
Reactive Oxygen Species
|
Metabolic Disease
Inflammation/Immunology
|
|
Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings [1] .
|
-
- HY-18071
-
BI-9627
2 Publications Verification
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Na+/H+ Exchanger (NHE)
|
Cardiovascular Disease
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|
BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury [1].
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- HY-18071A
-
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Na+/H+ Exchanger (NHE)
|
Cardiovascular Disease
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|
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury [1].
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- HY-W250127
-
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TerepHthalic acid disodium salt
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Biochemical Assay Reagents
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Others
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Disodium terephthalate belongs to the class of organic salts. It is commonly used as a catalyst or intermediate in the production of a variety of industrial and consumer products, including polyethylene terephthalate (PET) plastics, polyester fibers and films. Disodium terephthalate has excellent thermal stability, chemical resistance and mechanical properties, making it ideal for high performance applications. Additionally, it is non-toxic, non-flammable and environmentally friendly, making it an attractive alternative to other petroleum-based chemicals. In the food and pharmaceutical industries, Disodium terephthalate is used as a pH regulator and buffer. It is generally considered safe for use in food and pharmaceutical applications by regulatory agencies such as the FDA.
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- HY-W088066
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pHospHoric acid, sodium salt, hydrate (1:3:12)
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Biochemical Assay Reagents
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Others
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Trisodium phosphate dodecahydrate is a corrosion inhibitor for iron in 0.1 M NaClO4, in both aerated and deaerated solutions. Trisodium phosphate dodecahydrate can be used as an excipient, such as pH regulator, buffer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1] .
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- HY-125322
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Bacterial
|
Infection
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Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50=1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50=2.0 μg/mL for both).
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- HY-135078
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NSC 270912
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Others
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Others
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2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50=~1.25 mM).
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- HY-128067
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Hexamethylene amiloride; HMA
|
Sodium Channel
HIV
Apoptosis
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Infection
Cancer
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5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na +/H + exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively [1] .
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- HY-N0316
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JAK
NF-κB
Reactive Oxygen Species
Apoptosis
VEGFR
c-Myc
|
Cancer
|
|
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway [1] .
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- HY-W014837
-
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3-(1-Pyridinio)-1-propanesulfonate
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Biochemical Assay Reagents
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Others
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NDSB-201 consists of a pyridine group attached to a propane chain, which in turn is attached to a sulfonate group. This compound is commonly used as a buffer in biochemical and biological research, especially in electrophoretic applications. It maintains a stable pH in aqueous solutions and has low UV absorption, making it suitable for use in the UV spectrum. Furthermore, due to its ability to form stable complexes with DNA and other biomolecules, 3-(pyridin-1-ium-1-yl)propane-1-sulfonate has been investigated for its potential in drug delivery and genetic research.
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- HY-N2334AR
-
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Endogenous Metabolite
Apoptosis
STAT
BCL6
Interleukin Related
Caspase
|
Metabolic Disease
Cancer
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Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) [1] .
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- HY-138660
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HM-JF526 NHS
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Fluorescent Dye
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Others
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HM Janelia Fluor® 526, SE (HM-JF526 NHS) is a derivative of hydroxymethyl JF526 (HM-JF526). SMLM (single-molecule localization microscopy) imaging in standard phosphate-buffered saline (pH 7.4) revealed that the HM-JF526 label showed spontaneous blinking behavior throughout the imaging session and did not require short-wavelength activation light [1]. Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
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- HY-D1237
-
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Fluorescent Dye
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Metabolic Disease
|
|
BODIPY505/515 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 505/515 nm [1].
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- HY-D1570
-
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Fluorescent Dye
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Others
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BODIPYFL C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 480/508 nm [1].
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- HY-W090090
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Pyrromethene 546; BDP 493/503 lipid stain
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Fluorescent Dye
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Others
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BODIPY493/503 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 493/503 nm [1].
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- HY-138226
-
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Fluorescent Dye
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Others
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BODIPY 558/568 C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 558/568 nm [1].
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- HY-164575
-
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Radionuclide-Drug Conjugates (RDCs)
PSMA
|
Cancer
|
|
NH2-NODAGA is a NODAGA-type metal chelator that can bind to radionuclides to prepare radionuclide conjugates (RDCs). NH2-NODAGA can react with diethyl squarate in 0.5M phosphate buffer (room temperature, 2 h, pH 7-7.5) to obtain NODAGA.SA. NODAGA.SA can target L-lysine urea-L-glutamate (KuE), which is a key structure of prostate-specific membrane antigen (PSMA). NODAGA.SA.KuE can bind [68]Ga and can be used for PET examination of NMRInu/nu nude mice bearing LNCaP tumors.
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- HY-W087187
-
|
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Radionuclide-Drug Conjugates (RDCs)
EGFR
|
Cancer
|
|
DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.
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- HY-D1614
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Fluorescent Dye
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Others
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BODIPY493/503 methyl bromide is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 493/503 nm [1].
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- HY-N0316R
-
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JAK
NF-κB
Reactive Oxygen Species
Apoptosis
VEGFR
c-Myc
|
Cancer
|
|
Mollugin (Standard) is the analytical standard of Mollugin. This product is intended for research and analytical applications. Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway [1] .
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- HY-118124
-
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Endogenous Metabolite
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Others
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|
2-Iodoestradiol is a potent human sex hormone binding globulin (SHBG) ligand with a remarkably high affinity for SHBG. 2-Iodoestradiol exhibits competition for the same binding site as dihydrotestosterone in binding to human SHBG. The binding affinity constant of 2-Iodoestradiol at physiological pH and 37 degrees Celsius is 2.4 x 10(9) M-1, exceeding that for SHBG. 2-Iodoestradiol has been shown to bind to serum albumin, but with lower affinity. The radioisotope 125I-derivative of 2-Iodoestradiol has been used to study the binding properties of human SHBG, demonstrating its potential application in biological research [1].
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- HY-P2823
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Endogenous Metabolite
Biochemical Assay Reagents
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Others
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Trypsinogen, a proenzyme synthesized in the pancreas, is activated to form trypsin by enterokinase upon reaching the small intestine lumen, where it opens a hexapeptide bond at the Lys6 - Ile7 junction, leading to the production of the active enzyme. This single polypeptide chain, composed of 229 amino acids and stabilized by six disulfide bridges, further autocatalytically converts additional trypsinogen into trypsin, which is initially present as β-trypsin before undergoing autolysis at the Lys131 - Ser132 site to form α-trypsin. As a serine protease, trypsin features His46 and Ser183 at its active site and exhibits optimal enzymatic activity at a pH range of 7 to 9.
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- HY-D1617
-
|
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Fluorescent Dye
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Others
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|
BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 500/510 nm [1]. Protect from light, stored at -20℃.
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- HY-125372
-
|
ABAO
|
Biochemical Assay Reagents
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Others
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|
2-Amino benzamidoxime (ABAO compound 6) can react quickly with aldehydes to form stable 1, 2-dihydroquinazoline 3-oxides in aqueous solutions. The 2-Amino benzamidoxime reaction process consists of the formation of a Schiff base as a rate-determining step, followed by rapid intramolecular cyclization. The reaction rate is dependent on pH, indicating that protonated benzamidoxime is involved in the formation of Schiff bases as an internal generalized acid. Substituents on the aromatic ring can increase the alkalinity of the aromatic amine, thus speeding up the reaction. The reactive properties of 2-Amino benzamidoxime make it a potential platform for the development of new bioconjugated strategies, fluorescent probes, and post-translational diversification of genetic coding libraries [1].
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-
- HY-119417A
-
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Herbicide
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Others
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|
Chloramben sodium is a herbicide with anti-growth activity against plants. Chloramben sodium can be effectively removed by photo-Fenton reaction under natural pH conditions, showing good degradation performance. The removal rate of chloramben sodium is consistent with different electrodes, mainly due to the oxidation mediated by the hydroxyl ions formed in the Fenton reaction. Chloramben sodium is almost completely mineralized using IrO2-based electrodes at high current density, indicating that it can be effectively degraded under light. Chloramben sodium leads to the formation of persistent chlorine derivatives in chlorine-containing environments, so the removal rate and mineralization rate are slightly reduced. Chloramben sodium can form intermediates with a variety of aromatic compounds and organic acids, reflecting the complexity of its transformation in the environment [1].
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- HY-W145516
-
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Biochemical Assay Reagents
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Others
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|
Guar gum is a versatile polymer for drug delivery applications. Guar gum diaplays thickening, emulsifying, binding and gelling properties, quick solubility in cold water, wide pH stability, film forming ability and biodegradability, it finds applications in large number of industries. Guar gum can be isolated from the powdered endosperm of the seeds of the Cyamopsis tetragonolobus. Guar gum can be used as an excipient, such as thickener, suspending agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1] .
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-
- HY-W011422
-
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NSC 528
|
Fluorescent Dye
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Others
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|
2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone (NSC 528) is a colorimetric dye used for the detection of phenolic compounds. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone reacts with phenolic compounds at a pH of about 9.4 to produce an indigo dye. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone has been used as a Gibbs reagent for the colorimetric detection of phenolic compounds. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone has also been used in a colorimetric reaction for the quantitative colorimetric detection of aflatoxins, turning the colorless aflatoxins green with an absorption band at 673 nm.
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-
- HY-150175
-
|
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Fluorescent Dye
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Inflammation/Immunology
|
|
HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2 •−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2 •−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2 •− roles in inflammation, mitochondrial stress, and other physiological processes [1].
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-
- HY-W035903
-
|
2-Aminoethanol hydrochloride
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Biochemical Assay Reagents
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Others
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Ethanolamine hydrochloride, is an organic compound used in various industrial applications. It is a white or colorless solid that is soluble in water and has a faint odor. One of the major uses of Ethanolamine hydrochloride is in the production of detergents and surfactants. Used as a raw material in the manufacture of compounds such as ethylenediaminetetraacetic acid (EDTA) and diethanolamine, which are commonly used in household and industrial cleaning products. Ethanolamine hydrochloride is also used in the synthesis of pharmaceuticals, agrochemicals and rubber processing agents. It acts as a buffer in certain chemical reactions, helping to adjust pH and maintain stability. Ethanolamine hydrochloride can be used for gas purification and metal corrosion inhibitor. Its ability to react with acid gases such as carbon dioxide and sulfur dioxide makes it useful for removing impurities from natural gas and other industrial gases. Overall, Ethanolamine hydrochloride is a multifunctional compound with many potential industrial applications. Its ability to act as a buffer, chelating agent, and corrosion inhibitor makes it an important tool in a variety of industries.
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- HY-147414
-
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PF-114
|
Bcr-Abl
|
Cancer
|
|
Vamotinib (PF-114) is a potent, selective and orally active tyrosine kinase inhibitor. Vamotinib inhibits the autophosphorylation of BCR/ABL and BCR/ABL-T315I. Vamotinib induces apoptosis. Vamotinib shows anti-proliferative and anti-tumor activity. Vamotinib has the potential for the research of resistant philadelphia chromosome-positive (Ph+) leukemia. Vamotinib inhibits ABL series kinases with IC50s of 0.49 nM (ABL), 0.78 nM (ABL T315I), 9.5 nM (ABL E255K), 2.0 nM (ABL F317I), 7.4 nM (ABL G250E), 1.0 nM (ABL H396P), 2.8 nM (ABL M351T), 12 nM (ABL Q252H), and 4.1 nM (ABL Y253F), respectively [1] . Vamotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-153220
-
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PROTACs
Btk
|
Cancer
|
|
NX-2127 (compound 28) is an orally active PROTAC deggrader, targeting to Bruton’s Tyrosine Kinase (Btk) . NX-2127 inhibits proliferation of BTK C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells [1] . NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303). Among which, the conjugate of E3 ubiquitin ligase ligand + Linker compose of Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).
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- HY-D1560
-
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Fluorescent Dye
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Others
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FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well [1] .
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-
-
-
HY-L0116V
-
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1,065 compounds
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Macrocycles are promising scaffolds for the design of novel RNA targeting molecules. This collection of macrocycles for RNA consists of very diverse, drug-like molecules which incorporate certain known RNA-recognition elements (e.g. nucleobase ring systems and analogs) distributed within macrocyclic rings or peripheral fragments. As macrocyclic molecules tend to be larger than traditional screening molecules, it is vital to carefully assess and control their physicochemical properties. All macrocycles have been tested for aqueous and DMSO solubility with cutoffs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4); PAMPA permeability has also been tested for representative set of macrocycles.
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-
-
HY-L0115V
-
|
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10,091 compounds
|
|
ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks.
Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.
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| Cat. No. |
Product Name |
Type |
-
- HY-D1094
-
|
SNARF 1
|
Fluorescent Dyes/Probes
|
|
Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH. Carboxy-SNARF 1 (5/6-mixture) can be used for measurement pH [1].
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- HY-D1457
-
|
|
Fluorescent Dyes/Probes
|
|
DND-189, a low-pH fluorescent probe, is sensitive to neutral and low pH range. DND-189 can be used to measure the pH of acidic organelles [1] .
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- HY-D0265
-
|
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Indicators
Fluorescent Dyes/Probes
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|
Thymolphthalein is an electrochemically active dye due to the presence of thymol fragments. Thymolphthalein is a Phthalein dye used as an acid-base indicator. It is colourless in acid pH and is blue in basic pH [1].
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-
- HY-D0219A
-
|
|
Fluorescent Dyes/Probes
|
|
Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 [1].
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-
- HY-D0219
-
|
ThymolsulpHonepHthalein
|
Fluorescent Dyes/Probes
|
|
Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 [1]. Storage: protect from light.
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-
- HY-D1563
-
|
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Dyes
|
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CypHer 5 is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. CypHer 5 has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. CypHer 5 has been used as a pH sensor of lysosomal compartments [1].
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- HY-D0169A
-
|
pHenolsulfonepHthalein sodium salt
|
Dyes
|
|
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction [1] .
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-
- HY-128369
-
|
Metanil Yellow
|
Dyes
|
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Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes [1] .
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- HY-D1093
-
|
|
Fluorescent Dyes/Probes
|
|
Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe that is sensitive to pH. Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) can be used for measurement of intracellular pH [1].
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-
- HY-D0015A
-
|
|
Dyes
|
|
Cresol Red sodium is a triarylmethane dye. Cresol Red sodium can be used for indicating pH, temperatures and salinities [1].
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-
- HY-B1571
-
|
|
Dyes
|
|
Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6. Bromophenol blue is used as a sensor for the determination of several compounds including ammonia, drugs, proteins and amino acids. The binding of Bromophenol blue to proteins is accompanied by the appearance of a strong absorbance at 610 nm [1] .
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-
- HY-D1687
-
|
|
Fluorescent Dyes/Probes
|
|
Flubi-2 is a fluorescein-biotin based pH-ratio dye (Ex=480 nm, Em= 520-560 nm) with a pK value of 6.7. Flubi-2 is a hydrolysis product of Flubida-2 (non-fluorescent, membrane permeable). Flubi-2 can be used for pH determination of organelles of the secretory pathway (such as golgi apparatus and endoplasmic reticulum) in living cells [1] .
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-
- HY-D0140
-
|
ETH 5294
|
Fluorescent Dyes/Probes
|
|
Chromoionophore I (ETH 5294) is a hydrophobic pH indicator. Chromoionophore I is used as a transmissive or fluorescent probe molecule in many types of hydrophobic sensor membranes. Chromoionophore I is oil-soluble [1].
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-
- HY-D0023
-
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HPTS; Solvent Green 7
|
Fluorescent Dyes/Probes
|
|
Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu + ion(λex=450 nm, λem=510 nm) [1] .
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-
- HY-118320
-
|
Mordant orange 1
|
Fluorescent Dyes/Probes
|
|
Alizarine Yellow R (Mordant orange 1), a salicylic acid derivative, is a azo dye. Alizarine Yellow R is mostly used as a pH indicator, as a biological stain in chemical examinations and also in dyeing industries [1].
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-
- HY-D1069
-
|
DBCO-Sulfo-Cy3
|
Fluorescent Dyes/Probes
|
|
DBCO-Cy3 (DBCO-Sulfo-Cy3) is the derivative of Cyanine3 fluorophore, a pH insensitive from pH (4-10) orange fluorescent dyewith excitation maximum 555 nm and emission maximum of 580nm. DBCO-Cy3 has fast reaction kinetics and good stability, and is productive to use in many standard fluorescent instrumentations. DBCO-Cy3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- HY-D0169
-
|
pHenolsulfonepHthalein
|
Dyes
|
|
Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction [1] .
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- HY-D0009
-
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Dyes
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|
Bromocresol green sodium is an anionic dye. Bromocresol green sodium can be used for pH indication and DNA agarose gel electrophoresis. Bromocresol green sodium is also used in mammalian albumin measurement. Bromocresol green sodium deprotonates and produces the monoanionic form of yellow colour at lower pH (acidic condition), and produces dianionic blue colour at the basic condition [1].
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-
- HY-D1463
-
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Fluorescent Dyes/Probes
|
|
Nile Blue Methacrylamide is a Nile Blue-based nanosized pH densor that can be used for simultaneous far-red and near-infrared live bioimaging [1].
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- HY-118155
-
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Fluorescent Dyes/Probes
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|
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H +/solute antiport system [1].
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-
- HY-W411215
-
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|
Fluorescent Dyes/Probes
|
|
1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH [1].
|
-
- HY-D1591
-
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Fluorescent Dyes/Probes
|
|
BODIPY R6G methyl ester (compound 5′-1) is a BODIPY-like fluorescent dye with good light stability and insensitive to pH value. BODIPY R6G methyl ester shows good photostability, high sensitivity and insensitive to pH value. BODIPY R6G methyl ester can be used in research areas such as photodynamic research, PH probes, ion recognition, photocatalysis, protein labeling, cell imaging, and proteomic analysis [1].
|
-
- HY-D0142
-
|
|
Fluorescent Dyes/Probes
|
|
Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium is a fluorescent dye and pH indicator, also as a ligand of multifunctional metal-organic framework. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium has been used to detect CO2 release [1] .
|
-
- HY-B1422
-
|
Aminacrine
|
Fluorescent Dyes/Probes
|
|
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections [1] .
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-
- HY-B1422R
-
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|
Fluorescent Dyes/Probes
|
|
9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections [1] .
|
-
- HY-D1445
-
|
|
Fluorescent Dyes/Probes
|
|
PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes (Abs=329 nm; Em=440 nm) [1].
|
-
- HY-157036
-
|
|
Fluorescent Dyes/Probes
|
|
INSA is a a pH-sensitive fluorescent probe. INSA can simultaneously light up mitochondria (red emission) and lysosomes (green emission) for their internal pH differences [1].
|
-
- HY-D0075
-
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|
Fluorescent Dyes/Probes
|
|
DHPDS disodium salt is a pH-sensitive fluorescent dye. DHPDS disodium salt is used to measure intracellular pH (pHi) from the surface fluorescence of the isolated perfused rat liver [1].
|
-
- HY-D0012
-
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|
Dyes
|
|
Bromothymol Blue is a pH indicator.
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-
- HY-101882
-
BCECF
1 Publications Verification
2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein
|
Fluorescent Dyes/Probes
|
|
BCECF is a pH-sensitive fluorescent dye. BCECF allows measurements in the physiological pH range 6.0–8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm.
|
-
- HY-W331502
-
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|
Dyes
|
|
Chlorophenol Red sodium is a pH indicator [1].
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-
- HY-D2119
-
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Fluorescent Dyes/Probes
|
|
CQ-Lyso is a lysosome-targeting chromenoquinoline. CQ-Lyso is a fluorescent probe for measuring the pH of lysosomes in living cells using only single wavelength excitation. CQ-Lyso can visualize the dynamic pH changes in lysosomes [1].
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-
- HY-D0012A
-
-
- HY-D1111
-
|
AFDye 568 NHS Ester
|
Fluorescent Dyes/Probes
|
|
TFAX 568, SE is an orange fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 568, SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG) [1].
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-
- HY-W353607A
-
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Dyes
Indicators
|
|
Bromochlorophenol Blue sodium salt, an acid-sensitive dye, is a pH-indicating dye [1].
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-
- HY-D0228
-
|
Azo Violet; Magneson I
|
Dyes
|
|
4-(4-Nitrophenylazo)resorcinol is an azo purple dye used experimentally as a pH indicator, showing yellow when the pH value is lower than 11 and purple when the pH value is higher than 13. In slightly alkaline or alkaline environments, it also turns dark blue in the presence of magnesium salts. Azo Violet can also be used to test for the presence of ammonium ions. The color of the ammonium chloride or ammonium hydroxide solution will change depending on the concentration of azo violet used.
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-
- HY-D1110
-
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Fluorescent Dyes/Probes
|
|
TFAX 594,SE is a red fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 594,SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG) [1].
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-
- HY-D1113
-
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|
Fluorescent Dyes/Probes
|
|
TFAX 488,TFP is a green fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 488,TFP yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG, streptavidin) [1].
|
-
- HY-D1401
-
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Fluorescent Dyes/Probes
|
|
OG 488, acid, a fluorescent pH indicator, has many applications in biochemistry and neurosciences [1].
|
-
- HY-D1114
-
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|
Fluorescent Dyes/Probes
|
|
TFAX 488,SE dilithium is a green fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 488,SE dilithium yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG, streptavidin) [1].
|
-
- HY-101883
-
|
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Fluorescent Dyes/Probes
|
|
BCECF-AM is a cell membrane permeable compound widely used as a fluorescent indicator for intracellular pH.
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-
- HY-126774
-
|
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Fluorescent Dyes/Probes
|
|
DAF-FM is a diaminofluorescein, which can be used as fluorescent indicator for nitric oxide (NO) with good pH tolerance [1].
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-
- HY-D1366
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cyanine5.5 carboxylic acidCI Pigment violet 32 is a water-soluble, far-red emitting fluorophore. Due to its four sulfo groups, this dye has a negative charge at neutral pH and is very hydrophilic. As a cyanine dye, sulfo-Cyanine5.5 shows a very low dependence of fluorescence on pH and a very high extinction coefficient.
|
-
- HY-133527
-
|
Oregon green 488 succinimidyl ester
|
Dyes
|
|
OG 488, SE (Oregon green 488 succinimidyl ester), a fluorescent pH indicator, has many applications in biochemistry and neurosciences [1] .
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-
- HY-D0166
-
|
|
Dyes
|
|
Neutral Red, a nitrogenous pH-indicator with a pKi of 6.8, is an indicator for the internal acidification of thylakoids. Neutral Red stains lysosomes red [1].
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- HY-D1477
-
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Fluorescent Dyes/Probes
|
|
5(6)-Carboxyfluorescein diisobutyrate is a protected 5(6)-carboxyfluorescein. 5(6)-carboxyfluorescein is a fluorescence pH indicator [1].
|
-
- HY-15942
-
5-TAMRA
2 Publications Verification
|
Fluorescent Dyes/Probes
|
|
5-TAMRA can produce bright, pH-insensitive orange-red fluorescence (excitation and emission extremes of 546/579) and has good photostability.
|
-
- HY-D0048
-
|
5-TAMRA-NHS ester; 5-Carboxytetramethylrhodamine succinimidyl ester
|
Fluorescent Dyes/Probes
|
|
5-TAMRA-SE is an amine-reactive fluorescent agent, and its conjugate produces bright, pH-insensitive orange-red fluorescence with good photostability.
|
-
- HY-D1556
-
|
1,2-dioleoyl-sn-glycero-3-pHospHoethanolamine-N-(carboxyfluorescein) ammonium
|
Fluorescent Dyes/Probes
|
|
DOPE-CF is a pH-sensitive fluorescent membrane labelled probe with a fluorescein moiety that is a weak acid and a conjugated base that is highly fluorescent and can be attached to phospholipid ethanolamine lipids [1].
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-
- HY-15923
-
|
|
Fluorescent Dyes/Probes
|
|
MAOS is a modified Trinder’s reagent that can be used as a chromogenic probe for the determination of H2O2. MAOS is strongly dependent on the pH of the reaction medium [1].
|
- HY-158082A
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 20000
|
Cell Assay Reagents
Fluorescent Dyes/Probes
|
|
TRITC-dextran, MW 20000 (Tetramethyl rhodamine isothiocyanate glucan, MW 20000) is a fluorescent dye, with the molecular weight of 20 kD. TRITC-dextran MW 20000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 20000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 20000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
- HY-D2254
-
|
|
Fluorescent Dyes/Probes
|
|
CTB probe-1 (probe 1) a lysosome-targeting fluorogenic small-molecule probe for fluorescence imaging in living cells [1].
|
- HY-D0112
-
|
|
Fluorescent Dyes/Probes
|
|
7-Hydroxycoumarin-4-acetic acid, a pH-indicator dye, is covalently bound to bovine serum albumin (BSA) at the positions of reactive amino groups (λmax=326 nm) [1].
|
- HY-W040291
-
|
|
Fluorescent Dyes/Probes
|
|
7-Hydroxy-4-methylcoumarin-3-acetic acid, SE is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. It is widely used for preparing bioconjugates of blue fluorescence.
|
- HY-131510
-
|
SNARF-DE
|
Dyes
|
|
Chromoionophore XIII (SNARF-DE) is a pH senor that enables excitation with red light. Chromoionophore XIII functionality renders the indicator molecule lipophilic and water-insoluble but also prevents lactonization of the dye in an apolar environment [1].
|
- HY-D1082
-
|
|
Fluorescent Dyes/Probes
|
|
5-DTAF is a isomeric fluorescein derivative that directly react with polysaccharides and other alcohols in aqueous solution at pH ＞ 9. The maximum of the 5-DTAF emission profile is at a wavelength of 518 nm after excitation at 488 nm [1].
|
- HY-D1593
-
|
|
Fluorescent Dyes/Probes
|
|
BODIPY TMR-X alkyne, an orange-fluorescent dye, is an alkyne modified BODIPY TMR-X. BODIPY TMR-X alkyne can react with azides by the copper-catalyzed click reaction. BODIPY TMR-X alkyne is not sensitive to pH.
|
- HY-100045
-
|
4-NitropHenylpHospHorylcholine; 4-NitropHenylpHospHorylcholine; O-(4-NitropHenylpHospHoryl)choline
|
Fluorescent Dyes/Probes
|
|
p-Nitrophenyl phosphorylcholine (4-Nitrophenylphosphorylcholine) is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. Hydrolysis of p-nitrophenylphosphorylcholine by PLC results in the liberation of p-nitrophenol, which can be measured at 405 nm at pH 7.2-7.5.
|
- HY-D0952
-
|
|
Fluorescent Dyes/Probes
|
|
Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays [1] .
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- HY-D1549
-
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Dyes
|
|
o-Pah is a BODIPY derivative with an -NH2 and -OH substituted meso-Ph group. o-Pah exhibits metal-induced J-aggregation in the presence of Cu 2+ and a specific fluorescence enhancement for Hg 2+ (Ex/Em=483/(495-600) nM) [1].
|
- HY-130027
-
HKOCl-4
1 Publications Verification
BXY2142
|
Fluorescent Dyes/Probes
|
|
HKOCl-4 (BXY2142) is a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid with excellent sensitivity and selectivity [1]. HKOCl-4 has longer absorption wavelength and better pH stability compared with fluorescein-based probes. Ex: 530 nm; Em 557 nm.
|
- HY-110257
-
|
|
Fluorescent Dyes/Probes
|
|
BODIPY FL-X,SE is a fluorescent greendye for the labeling of amine, shows a high fluorescence quantum yield and is relatively insensitive to pH change. BODIPY FL-X,SE can be used as an alternative for FAM, Cy2 or FITC. λabs: 504 nm; λem:510 nm [1].
|
- HY-114352
-
|
|
Fluorescent Dyes/Probes
|
|
BODIPY FL-X is a green-fluorescent dye. BODIPY FL-X has the succinimidyl ester covalently coupled to proteins. BODIPY FL-X has high fluorescence quantum yield and is relatively insensitive to pH change. (λex=504 nm, λem=510 nm) [1] .
|
- HY-D1676
-
|
|
Fluorescent Dyes/Probes
|
|
Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum [1] .
|
- HY-W923198
-
|
Methacryloyloxy fluorescein
|
Fluorescent Dyes/Probes
|
|
Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-sensitive dye featuring a fluorescent monomer, characterized by an excitation spectrum at 490 nm and an emission spectrum at 520 nm. With fluorescein serving as an indicator that possesses minimal negative charges, it exhibits properties such as biocompatibility, non-toxicity, and excellent dispersion in aqueous solutions.
|
- HY-D2379A
-
|
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Fluorescent Dyes/Probes
|
|
closed-HMRG is HMRG with closed spirocyclic structure. Ac-HMRG, an acetylated derivative of Hydroxymethyl rhodamine green, exists as a closed spirocyclic structure in aqueous solution at physiological pH, whereas HMRG itself takes an open nonspirocyclic structure. Ac-HMRG is colorless and nonfluorescent and HMRG is strongly fluorescent [1].
|
- HY-D1654
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.
|
- HY-151544
-
|
|
Fluorescent Dyes/Probes
|
|
PNE-Lyso is a activatable fluorescent probe. PNE-Lyso can be used to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals. PNE-Lyso can be used to distinguish apoptosis from necrosis through visualizing lysosome morphology. PNE-Lyso is capable of investigating the agent-induced cell death process [1].
|
- HY-15940
-
|
5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers
|
Fluorescent Dyes/Probes
|
|
5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo [1] .
|
- HY-D1156
-
|
|
Fluorescent Dyes/Probes
|
HKSOX-1m (5/6-mixture) is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells [1].
|
- HY-D1156A
-
|
|
Fluorescent Dyes/Probes
|
HKSOX-1m (5/6-mixture) hydrobromide is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells [1].
|
- HY-D1688
-
|
|
Fluorescent Dyes/Probes
|
|
Flubida-2 is a cell permeable dye which can be hydrolyzed to Fubi-2 by endoesterases in cells (after hydrolysis, Ex=492 nm, Em=517 nm). Flubida-2 can be used to detect pH at a specific site in a cell organelle by directing the probe to where avidin fusion proteins are located [1].
|
- HY-151712
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent containing a methyltetrazine group. Sulfo-Cy5-Methyltetrazine acts as a fluorophore linker for trans-cyclooctene-based labeling. Sulfo-Cy5-Methyltetrazine shows good stability at physiological pH and is also highly reactive towards cyclooctene.
|
- HY-151713
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cy3-Methyltetrazine (figure 7 compound 5) is a click chemistry reagent containing methyltetrazine and a water-soluble dye. Sulfo-Cy3-Methyltetrazine shows good stability at physiological pH. Sulfo-Cy3-Methyltetrazine can be coupled to trans-cyclooctene and is also highly reactive towards cyclooctene [1].
|
- HY-D2083
-
|
|
Fluorescent Dyes/Probes
|
|
BODIPY 540 (purity>98%) is a BODIPY dye.BODIPY dye is a small molecule dye with strong UV absorption ability.Its fluorescence peak is relatively sharp, its quantum yield is high, and it is relatively insensitive to the polarity and pH value of the environment.BODIPY 540 (purity>98%) has a purity higher than 98% and is suitable for cell experiments [1].
|
- HY-D2379
-
|
|
Fluorescent Dyes/Probes
|
HMRG is a type of hydroxymethyl rhodamine green fluorescent scaffold, featuring an open non-cyclic structure. HMRG can produce significant dynamic fluorescence changes through a one-step enzymatic reaction at physiological pH, which is useful for developing various probes. Fluorescent probes based on HMRG can be used for fluorescence detection of diseases such as tumors and diabetic nephropathy [1].
|
- HY-D0914
-
|
FD&C Green No. 3; Food green 3; C.I. 42053
|
Dyes
|
|
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system [1].
|
- HY-D2324
-
|
|
Fluorescent Dyes/Probes
|
|
EE-Flipper 33 is a Flipper probe designed to evaluate the mechanism of early endocytosis. EE-Flipper has a pKa value of 10.6 and is capable of tracking approximately 70% of early endosomes (EE) in live cells. Furthermore, EE-Flipper 33 can also label the Golgi apparatus in live cells with an internal pH ranging from 6.0 to 6.7 [1].
|
- HY-15558
-
|
bisBenzimide H 33258; H 33258
|
DNA Stain
|
|
Hoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15559
-
Hoechst 33342
Maximum Cited Publications
60 Publications Verification
bisBenzimide H 33342; HOE 33342
|
DNA Stain
|
|
Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15560
-
|
HOE 34580
|
DNA Stain
|
|
Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15619
-
|
Nuclear yellow
|
DNA Stain
|
|
Hoechst S 769121 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15561
-
|
meta-Hoechst
|
DNA Stain
|
|
HOE-S 785026 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15562
-
|
|
DNA Stain
|
|
HOE 32021 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15622
-
|
|
DNA Stain
|
|
meta-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15623
-
|
|
DNA Stain
|
|
Hoechst 33258 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15626
-
|
|
DNA Stain
|
|
ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15627
-
|
|
DNA Stain
|
|
Hoechst 33342 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15629
-
|
|
DNA Stain
|
|
HOE 32020 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15632
-
|
|
DNA Stain
|
|
para-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15559A
-
|
bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride
|
DNA Stain
|
|
Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15561B
-
|
meta-Hoechst trihydrochloride
|
DNA Stain
|
|
HOE-S 785026 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15560B
-
|
HOE 34580 tetrahydrochloride
|
DNA Stain
|
|
Hoechst 34580 tetrahydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15558A
-
|
bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride
|
DNA Stain
|
|
Hoechst 33258 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15563
-
|
|
DNA Stain
|
|
HOE 33187 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15624
-
|
|
DNA Stain
|
|
Hoechst 33258 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15625
-
|
|
DNA Stain
|
|
Hoechst 33258 analog 3 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15628
-
|
|
DNA Stain
|
|
Hoechst 33258 analog 5 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15630
-
|
|
DNA Stain
|
|
Hoechst 33342 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15631
-
|
|
DNA Stain
|
|
Hoechst 33258 analog 6 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-15630A
-
|
|
DNA Stain
|
|
Hoechst 33342 analog 2 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution [1].
|
- HY-143285
-
|
|
Fluorescent Dyes/Probes
|
|
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate [1].
|
- HY-150086
-
|
CF4
|
Dyes
|
|
Copper Fluor-4 (CF4) is a Cu +-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9×10 −13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission) [1] .
|
- HY-D1106
-
|
|
Fluorescent Dyes/Probes
|
|
BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions [1]. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells .
|
- HY-D1237
-
|
|
Fluorescent Dyes/Probes
|
|
BODIPY505/515 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 505/515 nm [1].
|
- HY-D1570
-
|
|
Fluorescent Dyes/Probes
|
|
BODIPYFL C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 480/508 nm [1].
|
- HY-W090090
-
|
Pyrromethene 546; BDP 493/503 lipid stain
|
Fluorescent Dyes/Probes
|
|
BODIPY493/503 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 493/503 nm [1].
|
- HY-138226
-
|
|
Fluorescent Dyes/Probes
|
|
BODIPY 558/568 C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 558/568 nm [1].
|
- HY-D1617
-
|
|
Fluorescent Dyes/Probes
|
|
BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells [1]. Maximum excitation/emission wavelength: 500/510 nm [1]. Protect from light, stored at -20℃.
|
- HY-W011422
-
|
NSC 528
|
Fluorescent Dyes/Probes
|
|
2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone (NSC 528) is a colorimetric dye used for the detection of phenolic compounds. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone reacts with phenolic compounds at a pH of about 9.4 to produce an indigo dye. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone has been used as a Gibbs reagent for the colorimetric detection of phenolic compounds. 2,6-Dibromo-4-(chloroimino)cyclohexa-2,5-dienone has also been used in a colorimetric reaction for the quantitative colorimetric detection of aflatoxins, turning the colorless aflatoxins green with an absorption band at 673 nm.
|
- HY-D1560
-
|
|
Fluorescent Dyes/Probes
|
|
FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well [1] .
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| Cat. No. |
Product Name |
Type |
-
- HY-B1610N
-
|
|
Buffer Reagents
|
|
Sodium citrate buffer, 0.1M, pH 4.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.1M, pH 4.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.1M, pH 4.0 is the preferred solution for most antibodies [1]. Sodium citrate buffer, 0.1M, pH 4.0 is used in the hydration of liposome film .
|
-
- HY-B1610J
-
|
|
Buffer Reagents
|
|
Sodium citrate buffer, 0.5M, pH 5.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 5.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 5.0 is the preferred solution for most antibodies [1]. Sodium citrate buffer, 0.5M, pH 5.0 is used as solution for captisol in animal tumor models .
|
-
- HY-D0265
-
|
|
Indicators
Fluorescent Dyes/Probes
|
|
Thymolphthalein is an electrochemically active dye due to the presence of thymol fragments. Thymolphthalein is a Phthalein dye used as an acid-base indicator. It is colourless in acid pH and is blue in basic pH [1].
|
-
- HY-160113
-
|
|
Buffer Reagents
|
|
Sodium phosphate buffer (pH 6.9 0.02 mol/l) is a water-based salt solution. Sodium phosphate buffer (pH 6.9 0.02 mol/l) can be used in a variety of biochemical studies.
|
-
- HY-B1610K
-
|
|
Buffer Reagents
|
|
Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. [1].
|
-
- HY-B1610M
-
|
|
Buffer Reagents
|
|
Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies [1].
|
-
- HY-B1610L
-
|
|
Buffer Reagents
|
|
Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue [1].
|
-
- HY-D0252
-
|
|
Indicators
|
|
m-Cresol purple is a pH indicator dye with large cross section and halochromic property in neutral pH range [1].
|
-
- HY-Y0699
-
|
|
Indicators
|
|
Methyl red is an azo dye that acts as a pH indicator. Methyl red is red and yellow at pH 4.4 and 6.0 respectively [1].
|
-
- HY-W579346
-
|
|
Buffer Reagents
|
|
POPSO sesquisodium is a water-soluble zwitterionic buffer. POPSO sesquisodium is commonly used in biological and biochemical studies to maintain the acidity or alkalinity (pH value) of solutions, especially within the physiological pH range of 7.0 to 8.5 [1].
|
-
- HY-Y0699R
-
|
|
Indicators
|
|
Methyl red (Standard) is the analytical standard of Methyl red. This product is intended for research and analytical applications. Methyl red is an azo dye that acts as a pH indicator. Methyl red is red and yellow at pH 4.4 and 6.0 respectively [1].
|
-
- HY-160114
-
-
- HY-D0870
-
|
|
Buffer Reagents
|
|
CAPSO is a biological zwitterionic buffer with the useful pH range from 8.9 to 10.3 [1].
|
-
- HY-D0870A
-
|
|
Buffer Reagents
|
|
CAPSO sodium is a biological zwitterionic buffer with the useful pH range from 8.9 to 10.3 [1].
|
-
- HY-W011271
-
|
1,4-Piperazinediethanesulfonic acid monosodium
|
Buffer Reagents
|
|
PIPES (1,4-Piperazinediethanesulfonic acid) monosodium is a pH buffer that can be mixed with another disodium salt form of PIPES. By changing the ratio and total amount of the PIPES monosodium and disodium buffers, the pH and ionic strength of the medium can be changed [1].
|
-
- HY-D0276
-
|
Metacresol purple sodium
|
Indicators
|
|
m-Cresol purple sodium (Metacresol purple sodium) is a pH indicator. m-Cresol purple sodium solution from yellow to blue in the pH range from 7.5 to 9.0 [1].
|
-
- HY-W342700
-
|
|
Buffer Reagents
|
|
PIPPS is a kind of buffer commonly used in biological and biochemical research to maintain the acidity and alkalinity (pH value) of solutions [1].
|
-
- HY-Y0317IR
-
|
|
Buffer Reagents
|
|
Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP (Standard) is the analytical standard of Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP. This product is intended for research and analytical applications. Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-Y1968A
-
|
|
Biochemical Assay Reagents
|
|
Sterile 10 mM Histidine, pH 5.5 buffer is a multi-purpose buffer solution with important applications in many fields such as protein purification, vaccine preparation, drug development, cell culture and electrophoresis. Histidine is an amino acid with good buffering capacity. Sterile 10 mM Histidine, pH 5.5 buffer The sterility and specific pH conditions make it ideal for experiments that require precise control of environmental conditions. The histidine in Sterile 10 mM Histidine, pH 5.5 buffer derivatizes photosensitizers that accumulate and increase greatly upon exposure to light. Histidine-derived photosensitizers are also the primary mediators of tryptophan photooxidation [1].
|
-
- HY-Y0332L
-
|
Potassium pHospHate monobASIC, meets analytical specification of pH. Eur., NF, E340
|
Buffer Reagents
|
|
Potassium dihydrogen phosphate (Potassium phosphate monobasic), meets analytical specification of Ph. Eur., NF, E340 is used as a buffer capacity reagent in molecular biology, biochemistry, and chromatography. For the preparation of biological buffers. It is also used to purify antibodies, and in combination with other sodium phosphates, meets analytical specification of Ph. Eur., NF, E340 [1].
|
-
- HY-D0859A
-
|
|
Buffer Reagents
|
|
MOPS sodium salt is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media [1] .
|
-
- HY-W094708D
-
|
Disodium hydrogen pHospHate dihydrate, meets analytical specification of pH. Eur. BP
|
Buffer Reagents
|
|
Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP is an inorganic salt that can be used for life science related research [1].
|
-
- HY-Y0317I
-
|
Disodium sulfate, meets analytical specification of pH. Eur. BP USP
|
Buffer Reagents
|
|
Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-101850
-
|
|
Buffer Reagents
|
|
MOPSO is a biological zwitterionic buffer with the useful pH range from 6.2 to 7.6. MOPSO has been employed as a buffer component of charcoal yeast extract medium [1].
|
-
- HY-Y0344I
-
|
Halite, meets analytical specification of pH. Eur. BP USP
|
Buffer Reagents
|
|
Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-Y0319B3
-
|
|
Buffer Reagents
|
|
Potassium acetate meets analytical specification of Ph. Eur. BP E261, and can be used as food additives, medicine and cosmetics raw materials [1].
|
-
- HY-W087913
-
|
|
Biochemical Assay Reagents
|
|
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages [1].
|
-
- HY-Y0317E
-
|
Disodium sulfate (pHarmaceutical primary standard, USP)
|
Buffer Reagents
|
|
Sodium sulfate anhydrous (Disodium sulfate), can be widely used as a desiccant, pH regulator, etc. in biochemical experiments. It is a reference standard grade of the United States Pharmacopeia (USP), pharmaceutical primary standard.
|
-
- HY-W019885A
-
|
Sodium tripHospHate pentabASIC, 98%
|
Buffer Reagents
|
|
Sodium tripolyphosphate (STPP), 98% is a biochemical reagent that can be used as pH adjustment, chelating agent, and detergent additive [1].
|
-
- HY-W019885
-
|
Sodium tripHospHate pentabASIC, 85%
|
Buffer Reagents
|
|
Sodium tripolyphosphate (STPP), 85% (Sodium triphosphate pentabasic, 85%) is a biochemical reagent that can be used as pH adjustment, chelating agent, and detergent additive [1].
|
-
- HY-W094475D
-
|
Epsom salts, meets analytical specification of pH. Eur. BP USP FCC
|
Buffer Reagents
|
|
Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC is currently the anticonvulsant of choice for the prevention and control of eclamptic fits. Magnesium sulfate is also widely used as a tocolytic agent [1] .
|
-
- HY-D0874
-
|
|
Biochemical Assay Reagents
|
|
HEPPSO is a zwitterionic buffer. The working pH range of HEPPSO buffer is 7.1-8.5. HEPPSO displays relatively high ability to bind copper(II), has a pKa of 7.84 at 2.0 mM buffer concentration [1] .
|
-
- HY-Y1325H
-
|
|
Buffer Reagents
|
|
Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al is an inorganic salt that can be used for life science related research [1].
|
-
- HY-D0878
-
|
|
Biochemical Assay Reagents
|
|
TAPSO is a common biological buffer, a pH stabilization reagent, with effective pH ranging from 7-8, and pKa values ranging from 7.5–9.0. TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides [1].
|
-
- HY-Y1184C
-
|
Potassium hydrogen carbonate, meets analytical specification of pH. Eur., BP, USP, E501, 99.5%(T)
|
Buffer Reagents
|
|
Potassium bicarbonate (Potassium hydrogen carbonate) is a commonly used biochemical reagent. Potassium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, E501, 99.5%(T) can be used as a biomaterial related to life science research [1].
|
-
- HY-W694629
-
|
|
Buffer Reagents
|
|
Triethylammonium bicarbonate is a biochemical reagent that can be used to prepare buffer solutions that maintains the stable pH environment required for processes such as enzyme-catalyzed reactions [1].
|
-
- HY-108535
-
|
|
Buffer Reagents
|
|
HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis [1] .
|
-
- HY-W440988
-
|
|
Drug Delivery
|
|
DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner [1] .
|
-
- HY-D0872
-
|
|
Biochemical Assay Reagents
|
|
DIPSO is a biological zwitterionic buffer with the useful pH range from 7.0 to 8.2. DIPSO can interfere meiotic regulation in mouse oocytes. DIPSO also has surfactant activity at 10 mM [1] .
|
-
- HY-D0015
-
|
|
Indicators
|
|
Cresol red, 97% is an anionic dye used as a pH indicator (pH 1.8 orange - pH 2.0 yellow, pH 7.0 yellow - pH 8.8 purple).
|
-
- HY-W088071
-
|
|
Indicators
|
|
Litmus is a pH indicator, which is red at pH 4.5 and blue at pH 8.3.
|
-
- HY-W110789
-
|
|
Indicators
|
|
Ethyl Orange (sodium), indicator grade is an organic azo compound that can be used as a pH indicator from pH 3.0 to pH 4.8, changing color from red to orange.
|
-
- HY-125457
-
|
p-NapHtolbenzein
|
Indicators
|
|
α-Naphtholbenzein (p-Naphtolbenzein) is a dye. α-Naphtholbenzein can be used as a pH indicator. α-Naphtholbenzein has a visual transition from yellow (pH0-8.2) to turquoise (pH10). α-Naphtholbenzein is often used during sequential injection analysis technique done for acid-base titrations [1].
|
-
- HY-D0011
-
|
|
Biochemical Assay Reagents
|
|
Bromophenol blue sodium is a pH indicator. It changes from yellow at pH 3.0 to blue at pH 4.6. Bromophenol blue sodium is also used as a tracking dye to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis [1] .
|
-
- HY-D0856
-
|
|
Buffer Reagents
|
|
Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) [1] .
|
-
- HY-D0856R
-
|
|
Buffer Reagents
|
|
Bis-Tris (Standard) is the analytical standard of Bis-Tris. This product is intended for research and analytical applications. Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) [1] .
|
-
- HY-W110784
-
|
Diethyl red, 98%
|
Indicators
|
|
Ethyl Red, 98% is a pH indicator.
|
-
- HY-W342120
-
|
|
Indicators
|
|
Phenolphthalein (disodium), 95% is a pH indicator.
|
-
- HY-W110790
-
|
|
Indicators
|
|
Bromocresol purple (sodium) is a water-soluble dye, bromocresol purple sodium, commonly known as bromocresol purple, used as a pH indicator. The dye color changes from yellow to purple between pH 5.2 and 6.8.
|
-
- HY-W923277
-
|
|
Buffer Reagents
|
|
Sodium sesquicarbonate hydrate is a kind of buffering agent that can stabilize pH value by neutralizing acidic substances without causing a sharp change in pH value. This property makes it widely used in many fields, especially in maintaining acid-base balance in organisms.
|
- HY-W040144
-
|
|
Indicators
|
|
Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells [1] .
|
- HY-D0305
-
|
|
Biochemical Assay Reagents
|
|
Tropaeolin O is an acidic monoazo dye that undergoes a coupling reaction under pH=10.5 conditions to form a blue disazo dye. Tropaeolin O can be used for the determination of palladium(II), osmium(IV), albumin, and casein [1].
|
- HY-W087928
-
|
|
Indicators
|
|
Bromocresol purple is a pH indicator, whose color changes from yellow to purple when the pH increases from 5.2 to 6.8. Bromocresol purple can be used for detecting yeast cells with plasma membrane damage [1] .
|
- HY-W353607A
-
|
|
Dyes
Indicators
|
|
Bromochlorophenol Blue sodium salt, an acid-sensitive dye, is a pH-indicating dye [1].
|
- HY-W008865
-
|
|
Buffer Reagents
|
|
PIPES sesquisodium is a pH buffer. PIPES refers to Piperazine N-N’-bis [2 ethanol sulphonic acid, an organic based buffer. PIPES can be used in the preparation of a variety of marine and mammalian tissues for electron microscopic study, with pH range of 6.1-7.5 [1].
|
- HY-128545
-
|
Nitrazine paper; pHenapHthazine
|
Indicators
|
|
Nitrazine yellow (Nitrazine paper; Phenaphthazine) is a pH indicator. The color of Nitrazine yellow changes from yellow to blue in the pH range from 6.0 to 7.0. Nitrazine yellow is a kind of biological materials or organic compounds that are widely used in life science research [1].
|
- HY-D0858B
-
|
2-MorpHolinoethanesulpHonic acid sodium salt
|
Buffer Reagents
|
|
MES (2-Morpholinoethanesulphonic acid) sodium salt is a buffering agent in biology and biochemistry. MES sodium salt is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES sodium salt is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments [1] .
|
- HY-W250149
-
|
|
Biochemical Assay Reagents
|
|
Chlorophosphonazo III is a sensitive reagent for both calcium and magnesium. It is possible to determine calcium alone at pH 2.2 and calcium and magnesium at pH 7.0. Chlorophosphonazo III can also be used for the spectrophotometric determination of titanium, zirconium, thorium, and scandium, quinquevalent actinide elements, and protactinium [1].
|
- HY-144768
-
|
|
Drug Delivery
|
|
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive [1].
|
- HY-144025
-
|
|
Drug Delivery
|
|
DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery [1].
|
- HY-157379
-
|
|
Microbial Culture
|
|
YM Agar is a low pH growth medium for the cultivation of yeasts, molds and other acid-resistant microorganisms [1].
|
- HY-W013105
-
|
N-Cholylglycine sodium salt, 98%
|
Surfactants
|
|
Sodium glycocholate hydrate, 98% is a buffer commonly used in molecular biology and biochemical research, providing precise pH control in various experimental settings.
|
- HY-D0227F
-
|
Tris HCl (≥99%, reagent grade); Tris hydrochloride (≥99%, reagent grade)
|
Buffer Reagents
|
|
THAM hydrochloride (≥99%, reagent grade), also known as Tris-HCl, is a buffer commonly used in various biochemical and molecular biology applications to maintain a stable pH environment. Tris-HCl has unique chemical properties that allow it to resist changes in pH when acidic or basic substances are added, which makes it useful for stabilizing biological samples or reagents. It is commonly used in electrophoresis and protein purification procedures.
|
- HY-158082C
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 70000
|
Cell Assay Reagents
|
|
TRITC-dextran, MW 70000 (Tetramethyl rhodamine isothiocyanate glucan, MW 70000) is a fluorescent dye, with the molecular weight of 70 kD. TRITC-dextran, MW 70000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 70000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
- HY-D0869
-
|
N-Cyclohexyl-3-aminopropanesulfonic acid
|
Buffer Reagents
|
|
CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis [1] .
|
- HY-W096988A
-
|
|
Buffer Reagents
|
|
Sodium 1-hexanesulfonate (monohydrate) is an ion-pairing reagent and pH buffer used in the analysis of small organic compounds, pharmaceuticals, and metabolites by techniques such as HPLC.
|
- HY-W105686
-
|
|
Buffer Reagents
|
|
MOPS hemisodium salt, 98% is a buffer commonly used in molecular biology and biochemical research, providing precise pH control in various experimental settings.
|
- HY-Y0308D
-
|
Disodium hydrogen pHospHate, meets analytical specification of pH. Eur. BP USP FCC E339
|
Buffer Reagents
|
|
Sodium phosphate dibasic is commonly used as a food additive, buffer and laboratory reagent. Sodium phosphate dibasic has unique chemical properties that make it an important ingredient in the manufacture of fertilizers, detergents and water treatment products. Additionally, it is used in various medical applications such as osmotic laxatives and electrolyte replacement solutions [1] .
|
- HY-W105704
-
|
|
Buffer Reagents
|
|
HEPBS is a zwitterionic buffering agent with a pH range (7.6-9.0) similar to that of biological systems. HEPBS can be used in the culture of cells [1].
|
- HY-109541S6
-
|
(Rac)-DMPC-d72
|
Drug Delivery
|
|
(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d72 is deuterium labeled (Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-ph
|
- HY-D0867
-
|
|
Buffer Reagents
|
|
BES is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES is used in the diagnostic testing area.
|
- HY-D0867A
-
|
|
Buffer Reagents
|
|
BES sodium is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES sodium is used in the diagnostic testing area.
|
- HY-W099337
-
|
|
Carbohydrates
|
|
N-Ethyl-D-glucamine is a glucose derivative with biological activity as a buffer and chelating agent. Therefore, it is widely used in biochemical research to regulate pH and bind metal ions.
|
- HY-158082D
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 150000
|
Cell Assay Reagents
|
|
TRITC-dextran, MW 150000 (Tetramethyl rhodamine isothiocyanate glucan, MW 150000) is a fluorescent dye, with the molecular weight of 150 kD. TRITC-dextran, MW 150000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 150000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 150000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
- HY-158082E
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 500000
|
Cell Assay Reagents
|
|
TRITC-dextran, MW 500000 (Tetramethyl rhodamine isothiocyanate glucan, MW 500000) is a fluorescent dye, with the molecular weight of 500 kD. TRITC-dextran, MW 500000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 500000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 500000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
- HY-158082H
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 2000000
|
Cell Assay Reagents
|
|
TRITC-dextran, MW 2000000 (Tetramethyl rhodamine isothiocyanate glucan, MW 2000000) is a fluorescent dye, with the molecular weight of 2000 kD. TRITC-dextran, MW 2000000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 2000000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 2000000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
- HY-W460471
-
|
|
Buffer Reagents
|
|
Tris Buffered Saline is a common buffer reagent in molecular biology, consisting of Tris and NaCl. Tris Buffered Saline can adjust pH and ionic strength and is widely used in DNA/RNA extraction, PCR and protein electrophoresis. Tris Buffered Saline can purify and protect nucleic acid materials and improve reaction efficiency and concentration. In protein electrophoresis, Tris Buffered Saline stabilizes gels and maintains pH. Overall, Tris Buffered Saline offers versatility, good solubility, and low toxicity in molecular biology applications.
|
- HY-158082
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 4000
|
Cell Assay Reagents
|
|
TRITC-dextran MW 4000 (Tetramethyl rhodamine isothiocyanate glucan, MW 4000) is a fluorescent dye, with the molecular weight of 4 kD. TRITC-dextran MW 4000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 4000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 4000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
- HY-158082A
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 20000
|
Cell Assay Reagents
Fluorescent Dyes/Probes
|
|
TRITC-dextran, MW 20000 (Tetramethyl rhodamine isothiocyanate glucan, MW 20000) is a fluorescent dye, with the molecular weight of 20 kD. TRITC-dextran MW 20000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 20000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 20000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
- HY-158082B
-
|
Tetramethyl rhodamine isothiocyanate glucan, MW 40000
|
Cell Assay Reagents
|
|
TRITC-dextran, MW 40000 (Tetramethyl rhodamine isothiocyanate glucan, MW 40000) is a fluorescent dye, with the molecular weight of 40 kD. TRITC-dextran MW 40000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 40000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 40000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching [1] .
|
- HY-23430
-
|
|
Buffer Reagents
|
|
TES is a buffering agent (pKa=7.550 at 25°C). TES is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2 [1] .
|
- HY-23430A
-
|
|
Biochemical Assay Reagents
|
|
TES sodium is a buffering agent (pKa=7.550 at 25°C). TES sodium is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2 [1] .
|
- HY-B2243H
-
|
Sodium pHospHate monobASIC (USP); Monosodium dihydrogen orthopHospHate (USP); Monosodium pHospHate (USP)
|
Buffer Reagents
|
|
Anhydrous sodium dihydrogen phosphate, meets USP testing specifications is an inorganic salt. It is a chemical compound of sodium with a phosphate counter ion. Anhydrous sodium dihydrogen phosphate, meets USP testing specifications can be used as a pH buffer with other sodium phosphates [1].
|
- HY-W016352
-
|
Anilotic acid, 99%
|
Indicators
|
|
2-Hydroxy-5-nitrobenzoic acid, 99% is used as an HPLC analytical standard, pH indicator, and heavy metal detection agent, and is also used in the study of phenolic compounds oxidation.
|
- HY-158190
-
|
Rose Bengal Medium
|
Microbial Culture
|
|
Rose-Bengal Chloramphenicol Agar is a selective medium for the enumeration of yeasts and moulds from a wide variety of foodstuffs. The medium has a neutral pH and chloramphenicol is used as a selective agent to suppress the growth of bacteria [1].
|
- HY-D0857
-
HEPES
4 Publications Verification
|
Buffer Reagents
|
|
HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis [1] .
|
- HY-167003
-
|
|
Drug Delivery
|
|
L16 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. L16 can be used in the preparation of liposomes [1].
|
- HY-167004
-
|
|
Drug Delivery
|
|
IAJD93 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD93 can be used in the preparation of liposomes [1].
|
- HY-167004A
-
|
|
Drug Delivery
|
|
IAJD249 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. IAJD249 can be used in the preparation of liposomes [1].
|
- HY-167002
-
|
|
Drug Delivery
|
|
RM 137-15 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. RM 137-15 can be used in the preparation of liposomes [1].
|
- HY-167011
-
|
|
Drug Delivery
|
|
Al-28 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. Al-28 can be used in the preparation of liposomes [1].
|
- HY-167015
-
|
|
Drug Delivery
|
|
1O14 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 1O14 can be used in the preparation of liposomes [1].
|
- HY-138540
-
|
N-Dodecylimidazole
|
Cell Assay Reagents
|
|
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity [1] .
|
- HY-W110798
-
|
|
Indicators
|
|
Bromophenol blue indicator (3.0-4.6) is a synthetic dye commonly used as an acid-base indicator with a transition range of pH 3.0-4.6. Bromophenol blue indicator (3.0-4.6) is water soluble and changes color from yellow to blue as the pH of the solution changes from acidic to basic. Its unique chemical properties make it an important ingredient in a variety of scientific applications, especially in biochemistry and molecular biology. In addition, it can be used as a stain in microbiology and histology. However, Bromophenol blue indicator (3.0-4.6) has potential irritating and staining properties.
|
- HY-Y0537J
-
- HY-D0860
-
|
|
Buffer Reagents
|
|
Tricine is widely used as a buffer in protein electrophoresis, nucleic acid analysis, and immunology, which can help adjust pH and stabilize chemical reactions. In addition, the compound can also be used in research in certain medical fields, such as in antibody detection and drug screening.
|
- HY-W803862
-
|
|
Buffer Reagents
|
|
Tripotassium citrate is a compound containing potassium and citrate ions that has activity as a buffer, able to maintain a stable pH required for many enzymatic reactions and biochemical processes. Tripotassium citrate can be used as a buffer in enzyme assays to ensure the validity of experimental conditions.
|
- HY-D0873
-
|
EPPS
|
Buffer Reagents
|
|
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier [1].
|
- HY-D0877
-
|
|
Buffer Reagents
|
|
TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pKa value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH) [1] .
|
- HY-D0858
-
MES
1 Publications Verification
2-MorpHolinoethanesulpHonic acid
|
Buffer Reagents
|
|
MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
- HY-D0858A
-
|
2-MorpHolinoethanesulpHonic acid monohydrate
|
Buffer Reagents
|
|
MES (2-Morpholinoethanesulphonic acid) monohydrate is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES monohydrate is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
- HY-142981
-
|
DODA
|
Drug Delivery
|
|
Dioctadecylamine (DODA) is a secondary amine that has been shown to self-organize in plate-like structures in aqueous solution. Dioctadecylamine exhibits sufficiently hydrophobic properties of nanoparticles and good dispersibility in nonpolar solvent. Dioctadecylamine does not form a monolayer above pH 3.9 [1] .
|
- HY-D0858E
-
|
2-MorpHolinoethanesulpHonic acid potassium
|
Buffer Reagents
|
|
MES (2-Morpholinoethanesulphonic acid) potassium is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES potassium is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
- HY-D0858C
-
|
2-MorpHolinoethanesulpHonic acid hydrate
|
Buffer Reagents
|
|
MES (2-Morpholinoethanesulphonic acid) hydrate is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES hydrate is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
- HY-167545
-
|
POPE
|
Drug Delivery
|
|
1-Palmitoyl-2-oleoylphosphatidylethanolamine (POPE) is a PE-based synthetic phospholipid that can intercalate with other amphiphilic molecules to form stable bilayers at physiological pH. 1-Palmitoyl-2-oleoylphosphatidylethanolamine can be used in drug delivery research [1].
|
- HY-D0902
-
|
|
Biochemical Assay Reagents
|
|
Triethanolamine borate is a compound belonging to the class of borates. It is commonly used in the manufacture of personal care and cosmetics as an emulsifier, pH adjuster and buffer. Triethanolamine borate helps stabilize and thicken products such as lotions and creams and can improve their overall texture. It is also used in industrial applications such as the production of lubricants and metalworking fluids.
|
- HY-D0234
-
|
ortho-CresolpHthalein
|
Biochemical Assay Reagents
|
|
o-Cresolphthalein (ortho-Cresolphthalein) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
|
- HY-D0861
-
EGTA
Maximum Cited Publications
14 Publications Verification
|
Chelators
|
|
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages [1] .
|
- HY-D0876
-
|
|
Buffer Reagents
|
|
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC50 value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 [1] .
|
- HY-D0861A
-
|
|
Biochemical Assay Reagents
|
|
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages [1] .
|
- HY-150097
-
|
|
Native Proteins
|
|
Recombinant Human Serum Albumin (rHSA) is an active compound and possesses an identical conformation to plasma derived HSA. Recombinant Human Serum Albumin (rHSA) has no difference between rHSA and plasma derived HSA. The main physiological function of Recombinant Human Serum Albumin (rHSA) is to regulate plasma pH and maintain plasma osmotic pressure [1].
|
- HY-167012
-
|
|
Drug Delivery
|
|
306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes [1].
|
- HY-147087
-
|
|
Drug Delivery
|
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo [1].
|
- HY-B2217D
-
|
|
Buffer Reagents
|
|
Calcium hydroxide, ACS, 95% has high bactericidal activity and high pH. Calcium hydroxide, ACS, 95% has ability to induce hard tissue formation. Calcium hydroxide, ACS, 95% can dissociate into calcium (Ca) and hydroxyl ions (OH). Calcium hydroxide, ACS, 95% has the potential for intra-canal medicament research [1].
|
- HY-W440884
-
|
|
Drug Delivery
|
|
DSPE-PEG-Ald, MW 3400 is a self-assemble polyPEG which spontaneously forms lipid bilayer in water. The polymer can be used to prepare nanoparticles or liposomse as a targeted drug carrier, such as mRNA vaccine. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
|
- HY-D0858AR
-
|
|
Buffer Reagents
|
|
MES (monohydrate) (Standard) is the analytical standard of MES (monohydrate). This product is intended for research and analytical applications. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
|
- HY-W016352R
-
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Indicators
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2-Hydroxy-5-nitrobenzoic acid, 99% (Standard) is the analytical standard of 2-Hydroxy-5-nitrobenzoic acid, 99%. This product is intended for research and analytical applications. 2-Hydroxy-5-nitrobenzoic acid, 99% is used as an HPLC analytical standard, pH indicator, and heavy metal detection agent, and is also used in the study of phenolic compounds oxidation.
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- HY-W440885
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Drug Delivery
|
|
DSPE-PEG-Ald, MW 5000 is a phospholipid PEG polymer which can self-assemble spontaneously in water with their hydrophilic heads oriented toward the water (micelles). The polymer can be used to prepare liposome as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
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- HY-W250127
-
|
TerepHthalic acid disodium salt
|
Buffer Reagents
|
|
Disodium terephthalate belongs to the class of organic salts. It is commonly used as a catalyst or intermediate in the production of a variety of industrial and consumer products, including polyethylene terephthalate (PET) plastics, polyester fibers and films. Disodium terephthalate has excellent thermal stability, chemical resistance and mechanical properties, making it ideal for high performance applications. Additionally, it is non-toxic, non-flammable and environmentally friendly, making it an attractive alternative to other petroleum-based chemicals. In the food and pharmaceutical industries, Disodium terephthalate is used as a pH regulator and buffer. It is generally considered safe for use in food and pharmaceutical applications by regulatory agencies such as the FDA.
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- HY-W014837
-
|
3-(1-Pyridinio)-1-propanesulfonate
|
Buffer Reagents
|
|
NDSB-201 consists of a pyridine group attached to a propane chain, which in turn is attached to a sulfonate group. This compound is commonly used as a buffer in biochemical and biological research, especially in electrophoretic applications. It maintains a stable pH in aqueous solutions and has low UV absorption, making it suitable for use in the UV spectrum. Furthermore, due to its ability to form stable complexes with DNA and other biomolecules, 3-(pyridin-1-ium-1-yl)propane-1-sulfonate has been investigated for its potential in drug delivery and genetic research.
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- HY-P2823
-
|
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Biochemical Assay Reagents
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Trypsinogen, a proenzyme synthesized in the pancreas, is activated to form trypsin by enterokinase upon reaching the small intestine lumen, where it opens a hexapeptide bond at the Lys6 - Ile7 junction, leading to the production of the active enzyme. This single polypeptide chain, composed of 229 amino acids and stabilized by six disulfide bridges, further autocatalytically converts additional trypsinogen into trypsin, which is initially present as β-trypsin before undergoing autolysis at the Lys131 - Ser132 site to form α-trypsin. As a serine protease, trypsin features His46 and Ser183 at its active site and exhibits optimal enzymatic activity at a pH range of 7 to 9.
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- HY-W782399
-
|
Sodium boranocarbonate
|
Biochemical Assay Reagents
|
|
CORM-A1 (Sodium boranocarbonate) is a water-soluble carbon monoxide (CO) releasing molecule that facilitates the investigation of CO's impact on cellular systems. As CO is generated from heme degradation by the enzyme heme oxygenase, it serves as a crucial gaseous signaling mediator in mammalian cells. CORM-A1 not only exhibits anti-oxidant and anti-inflammatory properties but also regulates CO release in a manner dependent on pH and temperature, promoting mild vasorelaxation and hypotension. Furthermore, CORM-A1 has been shown to provide cytoprotection in primary cultures of astrocytes under oxidative stress while also enhancing autophagy due to its boron-containing composition.
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- HY-W035903
-
|
2-Aminoethanol hydrochloride
|
Buffer Reagents
|
|
Ethanolamine hydrochloride, is an organic compound used in various industrial applications. It is a white or colorless solid that is soluble in water and has a faint odor. One of the major uses of Ethanolamine hydrochloride is in the production of detergents and surfactants. Used as a raw material in the manufacture of compounds such as ethylenediaminetetraacetic acid (EDTA) and diethanolamine, which are commonly used in household and industrial cleaning products. Ethanolamine hydrochloride is also used in the synthesis of pharmaceuticals, agrochemicals and rubber processing agents. It acts as a buffer in certain chemical reactions, helping to adjust pH and maintain stability. Ethanolamine hydrochloride can be used for gas purification and metal corrosion inhibitor. Its ability to react with acid gases such as carbon dioxide and sulfur dioxide makes it useful for removing impurities from natural gas and other industrial gases. Overall, Ethanolamine hydrochloride is a multifunctional compound with many potential industrial applications. Its ability to act as a buffer, chelating agent, and corrosion inhibitor makes it an important tool in a variety of industries.
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P4116
-
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pHLIP
|
Peptides
|
Metabolic Disease
Cancer
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pH-Low Insertion Peptide (pHLIP) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide successfully modify polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide-based targeting of cancer presents an opportunity to monitor metabolic changes, and to selectively deliver imaging and therapeutic agents to tumors [1] .
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-
- HY-P4116A
-
|
pHLIP TFA
|
Peptides
|
Metabolic Disease
Cancer
|
|
pH-Low Insertion Peptide TFA (pHLIP TFA) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide TFA targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide TFA successfully modifys polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide TFA -based targeting of cancer presents an opportunity to monitor metabolic changes and to selectively deliver imaging and therapeutic agents to tumors [1] .
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-
- HY-W141932
-
|
Stearoylglycine; N-Octadecanoylglycine
|
Peptides
|
Others
|
|
N-stearoylglycine is a lipid and has a small ionizable polar headgroup whose charge is pH dependent and whose amide moiety can form H-bonded network between adjacent molecules in ordered films [1].
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-
- HY-P6021A
-
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Peptides
|
Others
|
|
HBpep-SP TFA is the TFA salt form of HBpep-SP (HY-P6021). HBpep-SP TFA is utilized for delivery and release of proteins, peptides and mRNA [1].
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-
- HY-P5172
-
|
|
Sodium Channel
|
Neurological Disease
|
|
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels [1].
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-
- HY-P10469
-
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NF-κB
|
Inflammation/Immunology
Cancer
|
|
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc [1].
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-
- HY-P6021
-
|
|
Peptides
|
Others
|
|
HBpep-SP is a peptide. HBpep-SP can be used for delivery and release of proteins [1].
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-
- HY-P4209
-
|
|
Peptides
|
Others
|
|
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity [1] .
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-
- HY-P4209A
-
|
|
Peptides
|
Others
|
|
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity [1] .
|
-
- HY-P10105
-
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Akt
Apoptosis
|
Cancer
|
|
TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo [1].
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-
- HY-P4579
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Biochemical Assay Reagents
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Others
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Pyr-Phe-OH is an effective pyrene-based hydrogel. Pyr Phe OH can self-assemble into hydrogels in the range of pH=7.5-14.0, and also shows a very low gel concentration (0.037% (w/v)) in phosphate buffer [1].
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-
- HY-P1315
-
|
Glycylglycyl-L-tyrosyl-L-arginine
|
Cathepsin
|
Others
|
|
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to papain, with a Ki of 9 μM at pH 6.2 [1].
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-
- HY-P5423
-
|
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Peptides
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Others
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|
GALA is a biological active peptide. (GALA, a pH-sensitive fusogenic peptide, is a promising method to accelerate this step in order to enhance the expression of the desired proteins.) [1]
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-
- HY-P4527
-
|
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Peptides
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Others
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|
Ala-Ala-βNA is a dipeptidyl-fl-naphthylamide (βNA). Ala-Ala-βNA is readily hydrolyzed, with optimum hydrolysis pH of 8.5-9.0 [1].
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-
- HY-P5405
-
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Transducible TAT-HA fusogenic peptide
|
Peptides
|
Others
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|
dTAT-HA2 enhances TAT-Cre escape from macropinosomes. dTAT-HA2 is a transfusible, pH-sensitive, fusogenic peptide [1].
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-
- HY-P5423A
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Peptides
|
Others
|
|
GALA (TFA) is a biological active peptide (GALA, a pH-sensitive fusogenic peptide, is a promising method to accelerate this step in order to enhance the expression of the desired proteins.) [1].
|
-
- HY-P0224
-
|
fMLP; N-Formyl-MLF
|
TNF Receptor
|
Inflammation/Immunology
|
|
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.
|
-
- HY-P2530
-
|
|
Peptides
|
Others
|
|
KALA is an amphiphilic peptide that forms an α-helical structure at physiological pH. KALA modifies a plasmid DNA-encapsulating liposomal membrane and is used as a fusogenic peptide in order to achieve effective liver targeting and transfection of DNA via galactose receptors [1].
|
-
- HY-P4773
-
|
|
HSV
|
Infection
|
|
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (kcat/Km) at pH 7.5 for cleavage is 5.2 M -1 s -1 [1].
|
-
- HY-114174
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing [1].
|
-
- HY-P4389
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
(Asp28)-Glucagon (1-29) (human, rat, porcine) is an optimized structure of glucagon, the 28th position is replaced by aspartic acid (Asp) which significantly increases the aqueous solubility of glucagon in a physiological pH buffer, has the same activity as glucagon [1].
|
-
- HY-P10294
-
|
|
Amyloid-β
|
Others
|
|
Oligopeptide P11-4 is an α-peptide that can be self-assembled into β-sheet amyloids with a hydrogel appearance at low pH. Oligopeptide P11-4 can be used in biomimetic mineralization, enamel regeneration and oral care agent [1].
|
-
- HY-P4522
-
|
|
Endogenous Metabolite
|
Others
|
|
Bz-Ala-Arg is a dipeptide. Bz-Ala-Arg is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg can be used to screen competitive inhibitors of these two enzymes [1].
|
-
- HY-P10742
-
|
|
Peptide-Drug Conjugates (PDCs)
Topoisomerase
|
Cancer
|
|
CBX-12 is a PDC (peptide drug conjugate) that targets tumors in an antigen-independent manner and exhibits antitumor activity. CBX-12 consists of a pH-sensitive peptide (pHLIP), a self-immolating linker, and a topoisomerase 1 (TOP1) inhibitor Exatecan (HY-13631) [1].
|
-
- HY-P4522A
-
|
|
Endogenous Metabolite
|
Others
|
|
Bz-Ala-Arg TFA is a dipeptide. Bz-Ala-Arg TFA is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg TFA can be used to screen competitive inhibitors of these two enzymes [1].
|
-
- HY-137798
-
|
|
Fluorescent Dye
|
Others
|
|
Chromozym PL is a chromogenic substrate for plasmin, and the enzymatic reaction can be carried out in 0.1mL Tris-HCl buffer (50 mM, pH 7.8). 100 μM Chromozym PL was dissolved and prepared. After adding the hydrolase, the generation of p-nitroaniline (pNA) at 405 nm was continuously observed, and the hydrolysis products were calculated [1].
|
-
- HY-P2435
-
|
|
Peptides
|
Others
|
|
Bz-Nle-Lys-Arg-Arg-AMC can be used for protease activity assay. In 0.1mL Tris-HCl buffer (50 mM, pH 7.8), Bz-Nle-Lys-Arg-Arg-AMC was hydrolyzed, and the release rate of AMC was observed and calculated at λex/λem=380 nm/460 nm [1].
|
-
- HY-P5780
-
|
|
Sodium Channel
|
Neurological Disease
|
|
π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC50 of 1-2 nM and potentiates ASIC1b with an EC50 of 46.5 nM [1].
|
-
- HY-P5174
-
|
|
Sodium Channel
|
Neurological Disease
|
|
MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC50 values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation [1].
|
-
- HY-P4108
-
|
|
Influenza Virus
|
Infection
|
|
TAT-HA2 Fusion Peptide is a peptide-based delivery agent that combines the pH-sensitive HA2 fusion peptide from Influenza and the cell-penetrating peptide TAT from HIV. TAT-HA2 Fusion Peptide is a transactivator of transcription and hemaglutanin for endosomal release. TAT-HA2 Fusion Peptide enhances cellular uptake of macromolecules [1].
|
-
- HY-P10228
-
|
|
Fungal
Bacterial
|
Infection
|
|
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner [1].
|
-
- HY-P5704
-
|
|
Bacterial
|
Infection
|
|
K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability [1].
|
-
- HY-P10329
-
|
|
Fungal
|
Infection
|
|
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 [1].
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-
- HY-P6020
-
|
|
Peptides
|
Others
|
|
HBpep-SA is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values below 6.5. HBpep-SA is able to directly and efficiently deliver a variety of macromolecules, ranging from therapeutic peptides as small as 726 Da to large enzymes as large as 430 kDa, and the loaded condensates remain stable under near-physiological and serum conditions until internalized by cells. HBpep-SA can be used for intracellular delivery of large numbers of macromolecules and as a vector for mRNA-based vaccines [1].
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-
- HY-P6020A
-
|
|
Peptides
|
Others
|
|
HBpep-SA is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values below 6.5. HBpep-SA is able to directly and efficiently deliver a variety of macromolecules, ranging from therapeutic peptides as small as 726 Da to large enzymes as large as 430 kDa, and the loaded condensates remain stable under near-physiological and serum conditions until internalized by cells. HBpep-SA can be used for intracellular delivery of large numbers of macromolecules and as a vector for mRNA-based vaccines [1].
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-
- HY-P6020B
-
|
|
Peptides
|
Others
|
|
HBpep-SA acetate is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values below 6.5. HBpep-SA acetate is able to directly and efficiently deliver a variety of macromolecules, ranging from therapeutic peptides as small as 726 Da to large enzymes as large as 430 kDa, and the loaded condensates remain stable under near-physiological and serum conditions until internalized by cells. HBpep-SA acetate can be used for intracellular delivery of large numbers of macromolecules and as a vector for mRNA-based vaccines [1].
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99037
-
|
M281
|
Fc Receptor (FcR)
|
Inflammation/Immunology
|
|
Nipocalimab (M281) is a fully human, recombinant, aglycosylated IgG1 monoclonal antibody. Nipocalimab is a human deglycosylated IgG1 anti-FcRn monoclonal antibody that binds with picomolar affinity to Fc receptor (FcRn) at both endosomal pH 6.0 and extracellular pH 7.6 [1] .
|
-
- HY-P99965
-
|
SKY59; RO7112689
|
Complement System
|
Cardiovascular Disease
Metabolic Disease
|
|
Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research [1] .
|
-
- HY-P99853
-
|
CR6261
|
Influenza Virus
|
Infection
|
|
Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus [1].
|
-
- HY-108798
-
|
|
VEGFR
|
Cardiovascular Disease
Cancer
|
|
Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases [1] .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-B1329
-
-
-
- HY-113377A
-
-
-
- HY-W002110
-
-
-
- HY-P2818
-
-
-
- HY-B1329R
-
-
-
- HY-113377
-
-
-
- HY-N2383
-
|
(1R,2S,3S,4S,6R)-4-Amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
|
Glycosidase
|
|
Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC50 value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme [1].
|
-
-
- HY-Y0367R
-
|
|
Structural Classification
Immune System Disorder
Ketones, Aldehydes, Acids
Source classification
Disease markers
Endogenous metabolite
|
Endogenous Metabolite
Bacterial
|
|
Maleic Acid (Standard) is the analytical standard of Maleic Acid. This product is intended for research and analytical applications. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
IC50 & Target: GAD [1] .
In Vitro: The MICs of WT 10403S for the acids (e.g., Maleic Acid) are 34 mM, 25 mM, 31 mM and 30 mM which correspond to pH values prior to growth of 4.84, 5.14, 5.32 and 5.02 respectively. Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal .
|
-
-
- HY-N11071
-
-
-
- HY-141475
-
-
-
- HY-149036
-
-
-
- HY-N8502
-
-
-
- HY-113314
-
-
-
- HY-100381
-
-
-
- HY-Y0836
-
-
-
- HY-N2334
-
-
-
- HY-N2334A
-
|
Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate
|
Structural Classification
Classification of Application Fields
Source classification
Endogenous metabolite
Disease Research Fields
Steroids
Cancer
|
Endogenous Metabolite
Apoptosis
STAT
BCL6
Interleukin Related
Caspase
|
|
Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) [1] .
|
-
-
- HY-100381R
-
-
-
- HY-Y0836R
-
|
|
Structural Classification
Natural Products
Microorganisms
other families
Source classification
Plants
|
Biochemical Assay Reagents
Reactive Oxygen Species
|
|
Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings [1] .
|
-
-
- HY-N0316
-
-
-
- HY-N2334AR
-
|
|
Structural Classification
Source classification
Endogenous metabolite
Steroids
|
Endogenous Metabolite
Apoptosis
STAT
BCL6
Interleukin Related
Caspase
|
|
Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) [1] .
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-
-
- HY-N0316R
-
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| Free Sample |
Yes
No
|
| Size |
* This product has been "discontinued".
Optimized version of product available:
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-D0857S
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HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].
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- HY-D0858S
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MES-d13 is the deuterium labeled MES. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies [1] .
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- HY-B0246S3
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Carbamazepine-(Ph)d8 (CBZ-(Ph)d8; NSC 169864-(Ph)d8) is the deuterium labeled Carbamazepine-(Ph) (HY-B0246) [1].
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-
-
- HY-109541S6
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(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d72 is deuterium labeled (Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-ph
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-
-
- HY-D0859S
-
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MOPS-d15 is the deuterium labeled MOPS[1]. MOPS is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media[2][3].
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-
-
- HY-23430S
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TES-d15 is the deuterium labeled TES[1]. TES is a buffering agent (pKa=7.550 at 25°C). TES is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2[2][3].
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-
-
- HY-D0869S
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3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].
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-
- HY-Y0836S1
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Diethyl succinate-d4 is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
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-
-
- HY-Y0836S
-
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Diethyl succinate- 13C4 is the 13C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
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-
-
- HY-B1422S
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9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections [1] .
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-
-
- HY-146659S
-
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S-Phenyl-DL-cysteine-3,3-d2 is the deuterium labeled S-Phenyl-DL-cysteine-3,3[1].
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-
-
- HY-17507S
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Pantoprazole-d6 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
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-
-
- HY-17507S1
-
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Pantoprazole-d3 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
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| Cat. No. |
Compare |
Product Name |
Application |
Reactivity |
Compare Products
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| Reactivity |
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| Application |
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Dilution
Ratio |
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| Molecular Weight |
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| Conjugation |
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| Clonality |
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| Immunogen |
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| Appearance |
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| Isotype |
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| Gene ID |
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| SwissProt ID |
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| Purity |
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| Formulation |
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| Free Sample |
Yes
No
|
| Size |
* This product has been "discontinued".
Optimized version of product available:
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-124480
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-126908
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130283
-
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|
|
Tetrazine
PROTAC Synthesis
|
|
Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130551
-
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|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-126524
-
|
|
|
ADC Synthesis
Azide
|
|
N3-Ph-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-Ph-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-133463
-
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|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133465
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-140349
-
|
|
|
PROTAC Synthesis
Azide
|
|
AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1]. AZD-CO-C2-Ph-amido-Ph-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130928
-
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|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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-
- HY-133504
-
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|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-Ph-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetrazine-Ph-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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-
- HY-133464
-
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|
|
Alkynes
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-133460
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133479
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133461
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133462
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130508
-
|
|
|
PROTAC Synthesis
Tetrazine
Azide
|
|
Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-130967
-
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|
|
Alkynes
ADC Synthesis
|
|
Ald-Ph-PEG4-bis-PEG4-propargyl is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Ald-Ph-PEG4-bis-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130974
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130667
-
|
|
|
PROTAC Synthesis
Azide
|
|
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Ald-Ph-amido-C2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-D1069
-
|
DBCO-Sulfo-Cy3
|
|
Labeling and Fluorescence Imaging
DBCO
|
|
DBCO-Cy3 (DBCO-Sulfo-Cy3) is the derivative of Cyanine3 fluorophore, a pH insensitive from pH (4-10) orange fluorescent dyewith excitation maximum 555 nm and emission maximum of 580nm. DBCO-Cy3 has fast reaction kinetics and good stability, and is productive to use in many standard fluorescent instrumentations. DBCO-Cy3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-133426
-
|
Ald-benzyl-amide-PEG4-propargyl
|
|
ADC Synthesis
Alkynes
|
|
Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Ald-Ph-amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130969
-
|
|
|
Azide
ADC Synthesis
|
|
Ald-Ph-PEG4-bis-PEG3-N3 is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Ald-Ph-PEG4-bis-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-131442
-
|
Alkyne tyramide; Alk-pH
|
|
Labeling and Fluorescence Imaging
Alkynes
|
|
Alkyne-phenol (Alk-Ph) is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne-phenol substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP). Alkyne-phenol also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins [1]. Alkyne-phenol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-145575
-
|
pH10
|
|
Alkynes
|
|
Itruvone is a intermediate of 17α-ethinylestradiol (EE2) during Fenton oxidation. Itruvone has an antidepressant effect [1] . Itruvone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-D1593
-
|
|
|
Labeling and Fluorescence Imaging
Alkynes
|
|
BODIPY TMR-X alkyne, an orange-fluorescent dye, is an alkyne modified BODIPY TMR-X. BODIPY TMR-X alkyne can react with azides by the copper-catalyzed click reaction. BODIPY TMR-X alkyne is not sensitive to pH.
|
-
- HY-159129
-
|
|
|
Azide
|
|
hCAXII-IN-10 (Compound 18b) is a dual inhibitor of human carbonic anhydrase isoform XII (hCAXII) and cathepsin B, with a Ki value of 2.2 nM. hCAXII-IN-10 can inhibit the role of hCAXII in providing tumors with a pH microenvironment conducive to tumor growth, and is expected to be used in the study of tumor diseases [1].
|
-
- HY-151712
-
|
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent containing a methyltetrazine group. Sulfo-Cy5-Methyltetrazine acts as a fluorophore linker for trans-cyclooctene-based labeling. Sulfo-Cy5-Methyltetrazine shows good stability at physiological pH and is also highly reactive towards cyclooctene.
|
-
- HY-151713
-
|
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
Sulfo-Cy3-Methyltetrazine (figure 7 compound 5) is a click chemistry reagent containing methyltetrazine and a water-soluble dye. Sulfo-Cy3-Methyltetrazine shows good stability at physiological pH. Sulfo-Cy3-Methyltetrazine can be coupled to trans-cyclooctene and is also highly reactive towards cyclooctene [1].
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W440988
-
|
|
|
Pegylated Lipids
|
|
DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner [1] .
|
-
- HY-144768
-
|
|
|
Cholesterol
|
|
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive [1].
|
-
- HY-139305
-
|
|
|
Cationic Lipids
|
|
CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response [1] .
|
-
- HY-132613
-
|
|
|
siRNAs
|
|
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) [1] .
|
-
- HY-144025
-
|
|
|
Cationic Lipids
|
|
DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery [1].
|
-
- HY-W440995
-
|
|
|
Pegylated Lipids
|
|
DOPE-PEG-Mal (MW 2000) is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. It is also reactive with thiol at pH 6.5 tp 7.5 to form a stable thioether bond.
|
-
- HY-167011
-
|
|
|
Cationic Lipids
|
|
Al-28 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. Al-28 can be used in the preparation of liposomes [1].
|
-
- HY-167015
-
|
|
|
Cationic Lipids
|
|
1O14 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 1O14 can be used in the preparation of liposomes [1].
|
-
- HY-132606
-
|
DCR-pHXC
|
|
siRNAs
|
|
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate [1] .
|
-
- HY-142981
-
|
DODA
|
|
Cationic Lipids
|
|
Dioctadecylamine (DODA) is a secondary amine that has been shown to self-organize in plate-like structures in aqueous solution. Dioctadecylamine exhibits sufficiently hydrophobic properties of nanoparticles and good dispersibility in nonpolar solvent. Dioctadecylamine does not form a monolayer above pH 3.9 [1] .
|
-
- HY-167012
-
|
|
|
Cationic Lipids
|
|
306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. 306Oi9-cis2 can be used in the preparation of liposomes [1].
|
-
- HY-132588
-
|
ALN-G01
|
|
siRNAs
|
|
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) [1] .
|
-
- HY-147087
-
|
|
|
Cationic Lipids
|
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo [1].
|
-
- HY-W440883
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG-Ald, MW 2000 is a phospholipid polyPEG which can self-assemble to form lipid bilayer in aqueous solution. The polymer can be used to prepare liposome as a drug delivery vehicle for administration of drugs or nutrients, such as mRNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
|
-
- HY-W019883
-
|
|
|
pH Modifiers
|
|
Dipotassium hydrogen phosphate is a highly water-soluble salt which is often used as a fertilizer, food additive and buffering agent. Dipotassium hydrogen phosphate can be used as an excipient, such as pH regulator, buffer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1] .
|
-
- HY-W088066
-
|
pHospHoric acid, sodium salt, hydrate (1:3:12)
|
|
pH Modifiers
|
|
Trisodium phosphate dodecahydrate is a corrosion inhibitor for iron in 0.1 M NaClO4, in both aerated and deaerated solutions. Trisodium phosphate dodecahydrate can be used as an excipient, such as pH regulator, buffer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1] .
|
-
- HY-W145516
-
|
|
|
Thickeners
Suspending Agents
|
|
Guar gum is a versatile polymer for drug delivery applications. Guar gum diaplays thickening, emulsifying, binding and gelling properties, quick solubility in cold water, wide pH stability, film forming ability and biodegradability, it finds applications in large number of industries. Guar gum can be isolated from the powdered endosperm of the seeds of the Cyamopsis tetragonolobus. Guar gum can be used as an excipient, such as thickener, suspending agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs [1] .
|
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![CHO-Ph-spiro[3.3]heptane-COOEt](http://file.medchemexpress.eu/product_pic/hy-159478.gif)
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