Search Result
Results for "
D<sub>3</sub>
" in MedChemExpress (MCE) Product Catalog:
757
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B1773AS5
-
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Mycoban-d<sub>3sub>; Napropion-d<sub>3sub>; Ocuseptine-d<sub>3sub>
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Isotope-Labeled Compounds
|
Others
|
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Sodium Propionate-d3 is the deuterium labeled Sodium Propionate[1].
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-
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- HY-113323S
-
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HMPG-d<sub>3sub>; MHPG-d<sub>3sub>; MOPEG-d<sub>3sub>
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Endogenous Metabolite
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Others
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3-Methoxy-4-hydroxyphenylglycol-d3 is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol.
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-
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- HY-B0113S
-
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H 16868-d<sub>3sub>
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Proton Pump
Bacterial
Autophagy
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Infection
Metabolic Disease
Cancer
|
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Omeprazole-d3 is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].
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-
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- HY-W008794S
-
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(±)-Normetanephrine-d<sub>3sub> hydrochloride; DL-Normetanephrine-d<sub>3sub> hydrochloride; (Rac)-Normetanephrine-d<sub>3sub> hydrochloride
|
Endogenous Metabolite
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Metabolic Disease
|
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Normetanephrine-d3 (hydrochloride) is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE)[1].
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-
-
- HY-66005S1
-
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Paracetamol-d<sub>3sub>; 4-Acetamidophenol-d<sub>3sub>; 4'-Hydroxyacetanilide-d<sub>3sub>
|
COX
Histone Acetyltransferase
Endogenous Metabolite
|
Inflammation/Immunology
|
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Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].
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-
-
- HY-B1689AS
-
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MTB 51-d<sub>3sub>; Mantheline-d<sub>3sub>; Metantyl-d<sub>3sub>; Metanyl-d<sub>3sub>; Metaxan-d<sub>3sub>; Methanide-d<sub>3sub>
|
Isotope-Labeled Compounds
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Others
|
|
Methantheline-d3 (bromide) is the deuterium labeled Methantheline bromide[1].
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-
-
- HY-17413S
-
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Azidothymidine-d<sub>3sub>; AZT-d<sub>3sub>; ZDV-d<sub>3sub>
|
Isotope-Labeled Compounds
HIV
|
Infection
Cancer
|
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Zidovudine-d3 is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
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-
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- HY-B0607S
-
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NTBC-d<sub>3sub>; Nitisone-d<sub>3sub>; SC0735-d<sub>3sub>
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Isotope-Labeled Compounds
HPPD
|
Metabolic Disease
|
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Nitisinone-d3 (NTBC-d3) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .
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-
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- HY-B0715S3
-
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BL-191-d<sub>3sub>; PTX-d<sub>3sub>; Oxpentifylline-d<sub>3sub>
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Isotope-Labeled Compounds
Autophagy
Phosphodiesterase (PDE)
HIV
|
Cardiovascular Disease
Cancer
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Pentoxifylline-d3 (BL-191-d3) is deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .
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- HY-B0457AS
-
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Chlorimipramine-d<sub>3sub>; G-34586-d<sub>3sub>; NSC-169865-d<sub>3sub>
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Serotonin Transporter
Dopamine Receptor
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Neurological Disease
|
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Clomipramine-d3 is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].
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-
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- HY-B0141AS
-
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Alfatradiol-d<sub>3sub>; Epiestradiol-d<sub>3sub>; Epiestrol-d<sub>3sub>
|
5 alpha Reductase
Endogenous Metabolite
|
Inflammation/Immunology
|
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Alpha-Estradiol-d3 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
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-
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- HY-N0176S
-
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Dihydroqinghaosu-d<sub>3sub>; β-Dihydroartemisinin-d<sub>3sub>; Artenimol-d<sub>3sub>
|
Parasite
NF-κB
Autophagy
Apoptosis
|
Infection
Cancer
|
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Dihydroartemisinin-d3 is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.
|
-
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- HY-13756S2
-
-
-
- HY-30151S
-
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8-Methoxypsoralen-d<sub>3sub>; Xanthotoxin-d<sub>3sub>; 8-MOP-d<sub>3sub>
|
Cytochrome P450
|
Inflammation/Immunology
|
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Methoxsalen-d3 is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].
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- HY-15330
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-
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- HY-13777S1
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Zoledronate-d<sub>3sub>; CGP 42446-d<sub>3sub>; CGP42446A-d<sub>3sub>; ZOL 446-d<sub>3sub>
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Isotope-Labeled Compounds
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Others
|
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Zoledronic acid-d3 is the deuterium labeled Zoledronic acid .
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-
-
- HY-B0479S
-
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Thiophenicol-d<sub>3sub>; Dextrosulphenidol-d<sub>3sub>
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Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
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Thiamphenicol-d3 is a deuterium labeled Thiamphenicol. Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].
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-
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- HY-N0108S
-
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Parietin-d<sub>3sub>; Rheochrysidin-d<sub>3sub>
|
Isotope-Labeled Compounds
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
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Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .
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-
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- HY-B0171S
-
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Phenazone-d<sub>3sub>; Phenazon-d<sub>3sub>
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Isotope-Labeled Compounds
|
Inflammation/Immunology
|
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Antipyrine-d3 is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity[1][2].
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-
-
- HY-N0136S
-
|
(+)-Dihydroquercetin-d<sub>3sub>; (+)-Taxifolin-d<sub>3sub>
|
Isotope-Labeled Compounds
Autophagy
Tyrosinase
|
Inflammation/Immunology
|
|
Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
|
-
-
- HY-B1110S
-
|
(±)-Nomifensine-d<sub>3sub> maleate; Nomifensin-d<sub>3sub> maleate
|
Isotope-Labeled Compounds
Dopamine Receptor
Adrenergic Receptor
|
Neurological Disease
|
|
Nomifensine-d3 ((±)-Nomifensine-d3) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .
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- HY-B1279AS
-
-
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- HY-13757AS1
-
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ICI 47699-d<sub>3sub>; (Z)-Tamoxifen-d<sub>3sub>; trans-Tamoxifen-d<sub>3sub>
|
Isotope-Labeled Compounds
Estrogen Receptor/ERR
Apoptosis
Autophagy
HSP
|
Cancer
|
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Tamoxifen-d3 is the deuterium labeled Tamoxifen . Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse .
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- HY-13757S
-
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ICI 46474-d<sub>3sub> hydrochloride; (Z)-Tamoxifen-d<sub>3sub> hydrochloride; trans-Tamoxifen-d<sub>3sub> hydrochloride
|
Apoptosis
Estrogen Receptor/ERR
Autophagy
HSP
Isotope-Labeled Compounds
|
Cancer
|
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Tamoxifen-d3 hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .
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- HY-10082S1
-
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3-AP-d<sub>3sub>; PAN-811-d<sub>3sub>; OCX191-d<sub>3sub>
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Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Cancer
|
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Triapine-d3 (3-AP-d3) is deuterium labeled Triapine. Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.
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- HY-B1658S
-
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(R)-Frovatriptan-d<sub>3sub> hydrochloride; SB 209509-d<sub>3sub> hydrochloride; VML 251-d<sub>3sub> hydrochloride
|
5-HT Receptor
|
Neurological Disease
|
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Frovatriptan-d3 (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].
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- HY-15027S1
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-
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- HY-W001158S1
-
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Dimethylglycine-d<sub>3sub> hydrochloride; DMG-d<sub>3sub> hydrochloride; N-Methylsarcosine-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Endogenous Metabolite
iGluR
Amino Acid Derivatives
|
Neurological Disease
Metabolic Disease
|
|
N,N-Dimethylglycine-d3 (Dimethylglycine-d3) hydrochloride is the deuterium labeled N,N-Dimethylglycine hydrochloride (HY-W001158). N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects .
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- HY-13636S
-
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ICI 182780-d<sub>3sub>; ZD 9238-d<sub>3sub>; ZM 182780-d<sub>3sub>
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Isotope-Labeled Compounds
Estrogen Receptor/ERR
Autophagy
Apoptosis
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Cancer
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Fulvestrant-d3 is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].
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- HY-17509S
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-
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- HY-B0264S
-
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Guaiacol glyceryl ether-d<sub>3sub>; Guaiphenesin-d<sub>3sub>; Glycerol guaiacolate-d<sub>3sub>
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Isotope-Labeled Compounds
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Neurological Disease
Inflammation/Immunology
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Guaifenesin-d3 is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].
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- HY-N0005S1
-
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Diferuloylmethane-d<sub>3sub>; Natural Yellow 3-d<sub>3sub>; Turmeric yellow-d<sub>3sub>
|
Isotope-Labeled Compounds
Autophagy
Histone Acetyltransferase
Keap1-Nrf2
Influenza Virus
Mitophagy
Epigenetic Reader Domain
Ferroptosis
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Cancer
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Curcumin-d3 (Diferuloylmethane-d3 ) is deuterium labeled Curcumin. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
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- HY-B0579S1
-
-
-
- HY-15202S1
-
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MEK162-d<sub>3sub>; ARRY-162-d<sub>3sub>; ARRY-438162-d<sub>3sub>
|
Isotope-Labeled Compounds
MEK
Autophagy
|
Cancer
|
|
Binimetinib-d3 (MEK162-d3) is deuterium labeled Binimetinib. Binimetinib (MEK162) is an oral and selective MEK1/2 inhibitor. Binimetinib (MEK162) inhibits MEK with an IC50 of 12 nM .
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- HY-10581AS
-
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AM-1155-d<sub>3sub> hydrochloride; BMS-206584-d<sub>3sub> hydrochloride; PD135432-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Bacterial
Topoisomerase
Antibiotic
|
Infection
|
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Gatifloxacin-d3 (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
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- HY-B1260S2
-
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CTAB-d<sub>3sub>; Cetyltrimethylammonium bromide-d<sub>3sub>; Hexadecyltrimethylammonium-d<sub>3sub> bromide
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Isotope-Labeled Compounds
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Others
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Cetrimonium-d3 (bromide) is the deuterium labeled Cetrimonium bromide[1].
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-
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- HY-15027S
-
-
-
- HY-B0647S1
-
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3-n-Butylphthalide-d<sub>3sub>; 3-Butylphthalide-d<sub>3sub>
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Isotope-Labeled Compounds
|
Neurological Disease
|
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Butylphthalide-d3 is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.
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-
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- HY-115127S
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-
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- HY-A0070AS3
-
-
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- HY-70002S
-
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Enzalutamide-d<sub>3sub>; MDV3100-d<sub>3sub>
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Androgen Receptor
Autophagy
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Cancer
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Deutenzalutamide (Enzalutamide-d3) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .
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- HY-41700S
-
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(R)-Alanine-d<sub>3sub>; Ba 2776-d<sub>3sub>; D-α-Alanine-d<sub>3sub>
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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D-Alanine-d3 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
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- HY-15455S2
-
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APTA-2217-d<sub>3sub>; BYK 20869-d<sub>3sub>; B9302-107-d<sub>3sub>
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Isotope-Labeled Compounds
Phosphodiesterase (PDE)
RSV
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Inflammation/Immunology
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Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
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- HY-B0215S
-
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N-Acetylcysteine-d<sub>3sub>; N-Acetyl-L-cysteine-d<sub>3sub>; NAC-d<sub>3sub>
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Isotope-Labeled Compounds
Reactive Oxygen Species
Endogenous Metabolite
Apoptosis
Ferroptosis
Influenza Virus
Disulfidptosis
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Infection
Neurological Disease
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Acetylcysteine-d3 is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .
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- HY-B0389S7
-
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Glucose-d<sub>1sub>-3; D-(+)-Glucose-d<sub>1sub>-3; Dextrose-d<sub>1sub>-3
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Endogenous Metabolite
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Metabolic Disease
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D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-113015S
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-
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- HY-127165S1
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HP 029-d<sub>3sub>; Hydroxytacrine-d<sub>3sub> maleate
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Isotope-Labeled Compounds
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Others
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Velnacrine-d3 (maleate) is the deuterium labeled Velnacrine maleate[1].
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-
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- HY-B0094S
-
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Qinghaosu-d<sub>3sub>; NSC 369397-d<sub>3sub>
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Akt
Ferroptosis
HCV
Parasite
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Infection
Neurological Disease
Cancer
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Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].
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- HY-B0105BS
-
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(-)-Ketoconazol-d<sub>3sub>; (-)-R 41400-d<sub>3sub>
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Fungal
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Infection
Inflammation/Immunology
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(-)-Ketoconazole-d3 is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).
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- HY-101037S1
-
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N-Methylglycine-d<sub>3sub>; Sarcosin-d<sub>3sub>
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Isotope-Labeled Compounds
Endogenous Metabolite
GlyT
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Cancer
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Sarcosine-d3 is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
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- HY-W654101
-
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Cefotaxim-d<sub>3sub>; HR-756-d<sub>3sub>
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Isotope-Labeled Compounds
Antibiotic
Bacterial
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Infection
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Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
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- HY-10219S
-
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Sirolimus-d<sub>3sub>; AY-22989-d<sub>3sub>
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Isotope-Labeled Compounds
mTOR
FKBP
Autophagy
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Cancer
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Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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- HY-B1374S1
-
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(-)-Florfenicol-d<sub>3sub>; SCH-25298-d<sub>3sub>
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Isotope-Labeled Compounds
Bacterial
Antibiotic
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Infection
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Florfenicol-d3 is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.
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- HY-B0271S
-
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Pyrazinecarboxamide-d<sub>3sub>; Pyrazinoic acid amide-d<sub>3sub>
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Isotope-Labeled Compounds
Bacterial
Autophagy
Antibiotic
|
Infection
|
|
Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].
|
-
- HY-14654S
-
-
- HY-N0054S
-
|
Osthol-d<sub>3sub>; NSC 31868-d<sub>3sub>
|
Apoptosis
|
Cancer
|
|
Osthole-d3 (Osthol-d3) is the deuterium-labeled Osthole (HY-N0054) .
|
-
- HY-B1037S
-
|
Albuterol-d<sub>3sub>; AH-3365-d<sub>3sub>
|
Adrenergic Receptor
|
Neurological Disease
Endocrinology
|
|
Salbutamol-d3 is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).
|
-
- HY-17021S2
-
|
(S)-Omeprazole-d<sub>3sub> potassium; (-)-Omeprazole-d<sub>3sub> potassium
|
Bacterial
Proton Pump
Isotope-Labeled Compounds
|
Inflammation/Immunology
Endocrinology
Cancer
|
|
Esomeprazole-d3 potassium is deuterated labeled Esomeprazole (HY-17021). Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H +, K +-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .
|
-
- HY-N0623S9
-
|
Tryptophan-d<sub>3sub>; Tryptophane-d<sub>3sub>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Tryptophan-d3 is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
|
-
- HY-15345AS
-
|
THU-d<sub>3sub>; NSC-112907-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Tetrahydrouridine-d3 is the deuterium labeled Tetrahydrouridine[1]. Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine[2][3].
|
-
- HY-17021S1
-
|
(S)-Omeprazole-d<sub>3sub>; (-)-Omeprazole-d<sub>3sub>
|
Isotope-Labeled Compounds
Proton Pump
|
Inflammation/Immunology
Endocrinology
Cancer
|
|
Esomeprazole-d3 is deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].
|
-
- HY-121309S
-
|
Adriamycin aglycone-d<sub>3sub>; Adriamycinone-d<sub>3sub>
|
Endogenous Metabolite
|
Cancer
|
|
Doxorubicinone-d3 is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
|
-
- HY-B0272S
-
|
Rifampin-d<sub>3sub>; Rifamycin AMP-d<sub>3sub>
|
Bacterial
Influenza Virus
Antibiotic
|
Infection
|
|
Rifampicin-d3 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities[1][2].
|
-
- HY-40354S5
-
|
Tasocitinib-d<sub>3sub>; CP-690550-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
Cancer
|
|
Tofacitinib-d3 (Tasocitinib-d3) is deuterium labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
|
-
- HY-B0150S3
-
|
Niacinamide-d<sub>3sub>; Nicotinic acid amide-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
Organoid
Sirtuin
HBV
|
Cancer
|
|
Nicotinamide-d3 (Niacinamide-d3) is deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .
|
-
- HY-N1150S
-
|
DThyd-d<sub>3sub>; NSC 21548-d<sub>3sub>
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Others
|
|
Thymidine-d3 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].
|
-
- HY-A0088S
-
|
Cefotaxim-d<sub>3sub> sodium; HR-756-d<sub>3sub> sodium
|
Isotope-Labeled Compounds
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
|
Cefotaxime-d3 (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4][5].
|
-
- HY-13632S2
-
|
FCE 24304-d<sub>3sub>; EXE-d<sub>3sub>
|
Isotope-Labeled Compounds
Cytochrome P450
|
Endocrinology
Cancer
|
|
Exemestane-d3 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
|
-
- HY-B1836S
-
|
MET-88-d<sub>3sub>; Quaterin-d<sub>3sub>
|
Isotope-Labeled Compounds
Mitochondrial Metabolism
|
Cardiovascular Disease
Metabolic Disease
|
|
Meldonium-d3 is the deuterated form of Meldonium. Meldonium is a cardiovascular protective agent that competitively inhibits BBOX1 and OCTN2. The IC50 value of Mildronate against human recombinant BBOX is 34-62 μM, and the EC50 value against human OCTN2 is 21 μM. Meldonium is a fatty acid oxidation inhibitor .
|
-
- HY-107855S1
-
|
(±)-Mevalonolactone-d<sub>3sub>; Mevalolactone-d<sub>3sub>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3].
|
-
- HY-Y0842S1
-
|
Methanamide-d<sub>3sub>; Formimidic acid-d<sub>3sub>
|
Endogenous Metabolite
|
Others
|
|
Formamide-d3 is the deuterium labeled Formamide. Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.
|
-
- HY-17021S
-
|
(S)-Omeprazole-d<sub>3sub> sodium; (-)-Omeprazole-d<sub>3sub> sodium
|
Isotope-Labeled Compounds
Proton Pump
|
Inflammation/Immunology
Endocrinology
Cancer
|
|
Esomeprazole-d3 (sodium) is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].
|
-
- HY-B0115S
-
-
- HY-15398S3
-
-
- HY-13694S
-
-
- HY-15772S3
-
|
asandeutertinibum; Osimertinib-d<sub>3sub>; AZD-9291-d<sub>3sub>
|
EGFR
|
Cancer
|
|
Asandeutertinib (Osimertinib-d3; AZD-9291-d3) is a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with antineoplastic effect .
|
-
- HY-N0402S
-
|
Dihydroqinghaosu methyl ether-d<sub>3sub>; Dihydroartemisinin methyl ether-d<sub>3sub>; SM224-d<sub>3sub>
|
Isotope-Labeled Compounds
Parasite
|
Infection
Cancer
|
|
Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.
|
-
- HY-17452AS
-
|
Cefditoren pivoxyl-d<sub>3sub>; Cefditoren pivaloyloxymethyl ester-d<sub>3sub>; ME 1207-d<sub>3sub>
|
Isotope-Labeled Compounds
Antibiotic
Beta-lactamase
Bacterial
|
Infection
Inflammation/Immunology
|
|
Cefditoren Pivoxil-d3 (Cefditoren pivoxyl-d3) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
|
-
- HY-B0302AS
-
|
Etidronate-d<sub>3sub> disodium; HEDPA-d<sub>3sub> disodium; HEDP-d<sub>3sub> disodium
|
Apoptosis
Isotope-Labeled Compounds
|
Others
|
|
Etidronic acid-d3 (disodium) is the deuterium labeled Etidronic acid disodium[1].
|
-
- HY-101064S2
-
|
N-FMOC-leucine-d<sub>3sub>; NPC 15199-d<sub>3sub>; NSC 334290-d<sub>3sub>
|
PPAR
|
Metabolic Disease
|
|
Fmoc-leucine-d3 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
|
-
- HY-13318S
-
|
GS 4071-d<sub>3sub>; Ro 64-0802-d<sub>3sub>; Oseltamivir carboxylate-d<sub>3sub>
|
Influenza Virus
|
Infection
|
|
Oseltamivir acid-d3 is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses[1][2].
|
-
- HY-107854S
-
|
N-Acetylserotonin-d<sub>3sub>; Normelatonin-d<sub>3sub>; O-Demethylmelatonin-d<sub>3sub>
|
Endogenous Metabolite
Trk Receptor
|
Neurological Disease
|
|
N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].
|
-
- HY-B0457S
-
|
Chlorimipramine-d<sub>3sub> (hydrochloride); G-34586-d<sub>3sub> (hydrochloride); NSC-169865-d<sub>3sub> (hydrochloride)
|
Serotonin Transporter
Dopamine Receptor
|
Neurological Disease
|
|
Clomipramine-d3 (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].
|
-
- HY-B0617S
-
|
S-Adenosyl methionine-d<sub>3sub>; Ademetionine-d<sub>3sub>; AdoMet-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) is the deuterated product of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .
|
-
- HY-75087S
-
|
(+)-(R)-Proline-d<sub>3sub>; (R)-(+)-Proline-d<sub>3sub>; (R)-2-Carboxypyrrolidine-d<sub>3sub>; (R)-Proline-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-Pyrrolidine-2-carboxylic acid-d3 is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.
|
-
- HY-B1189S
-
|
Dicrotalic acid-d<sub>3sub>; 3-Hydroxy-3-methylglutaric acid-d<sub>3sub>
|
Autophagy
HMG-CoA Reductase (HMGCR)
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Meglutol-d3 is the deuterium labeled Meglutol[1]. Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.
|
-
- HY-W007355S
-
-
- HY-109171S
-
|
NT-814-d<sub>3sub>; BAY3427080-d<sub>3sub>
|
Isotope-Labeled Compounds
Neurokinin Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
Elinzanetant-d3 (NT-814-d3) is deuterium labeled Elinzanetant. Elizanetant (NT-814) is an orally active, selective NK-1,3 receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women .
|
-
- HY-N0684S4
-
-
- HY-N0650S8
-
|
(-)-Serine-d<sub>3sub>; (S)-Serine-d<sub>3sub>
|
Endogenous Metabolite
|
Cancer
|
|
L-Serine-d3 is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-B0002BS1
-
|
GR 38032-d<sub>3sub>; SN 307-d<sub>3sub>
|
5-HT Receptor
|
Neurological Disease
|
|
Ondansetron-d3 is the deuterium labeled Ondansetron[1]. Ondansetron(GR 38032;SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2].
|
-
- HY-13683S
-
-
- HY-B1059S
-
|
RV-12309-d<sub>3sub>; S-(-)-Sulpiride-d<sub>3sub>
|
Isotope-Labeled Compounds
Dopamine Receptor
|
Neurological Disease
|
|
Levosulpiride-d3 is the deuterium labeled Levosulpiride. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class[1][2].
|
-
- HY-15321S2
-
|
MK-0663-d<sub>3sub>; L-791456-d<sub>3sub>
|
COX
|
Inflammation/Immunology
|
|
Etoricoxib-d3 is the deuterium labeled Etoricoxib[1]. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood[2][3][4].
|
-
- HY-B0352S
-
|
Org3770 d<sub>3sub>; 6-Azamianserin d<sub>3sub>
|
5-HT Receptor
|
Neurological Disease
|
|
Mirtazapine-d3 is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].
|
-
- HY-14268S2
-
-
- HY-16973S4
-
|
A1443-d<sub>3sub>; AH252723-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Infection
|
|
Fluralaner-d3 (A1443-d3) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
|
-
- HY-B0966S
-
|
Benzophenone-8-d<sub>3sub>; UV-24-d<sub>3sub>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Inflammation/Immunology
Cancer
|
|
Dioxybenzone-d3 is deuterium labeled Dioxybenzone. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study .
|
-
- HY-17507S1
-
|
BY1023-d<sub>3sub>; SKF96022-d<sub>3sub>
|
Isotope-Labeled Compounds
Proton Pump
Autophagy
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Pantoprazole-d3 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
|
-
- HY-12519S
-
|
RP 35972-d<sub>3sub>; NSC 347901-d<sub>3sub>
|
Isotope-Labeled Compounds
HIF/HIF Prolyl-Hydroxylase
HIV
Keap1-Nrf2
|
Cancer
|
|
Oltipraz-d3 is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
|
-
- HY-16293S
-
|
PM01183-d<sub>3sub>; LY-01017-d<sub>3sub>
|
DNA Alkylator/Crosslinker
DNA/RNA Synthesis
|
Cancer
|
|
Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].
|
-
- HY-B0905S
-
|
LY-177370-d<sub>3sub>; EL-870-d<sub>3sub>
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
Apoptosis
NO Synthase
COX
|
Infection
Inflammation/Immunology
|
|
Tilmicosin-d3 is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects .
|
-
- HY-104074S
-
|
SCH-48973-d<sub>3sub>; V-073-d<sub>3sub>
|
Isotope-Labeled Compounds
Enterovirus
|
Others
|
|
Pocapavir-d3 (SCH-48973-d3; V-073-d3) is the deuterium labeled Pocapavir (HY-104074) . Pocapavir (SCH-48973) is an orally active capsid inhibitor. Pocapavir prevents virion uncoating upon entry into the cell. Pocapavir has antiviral activity against polioviruses. Pocapavir also inhibits enterovirus infections .
|
-
- HY-15851S2
-
-
- HY-B0801S2
-
|
MDL-16455-d<sub>3sub>; Terfenadine carboxylate-d<sub>3sub>
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Fexofenadine-d3 is the deuterium labeled Fexofenadine[1]. Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[2][3][4].
|
-
- HY-12785S
-
|
Ricobendazole d<sub>3sub>; Albendazole oxide d<sub>3sub>
|
Parasite
|
Inflammation/Immunology
|
|
Albendazole sulfoxide-d3 is deuterium labeled Albendazole sulfoxide, which is a broad-spectrum anthelmintic.
|
-
- HY-B0469S
-
-
- HY-108325S
-
-
- HY-A0064S
-
|
(±)-Verapamil-d<sub>3sub> hydrochloride; CP-16533-1-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Calcium Channel
P-glycoprotein
Cytochrome P450
|
Cardiovascular Disease
|
|
Verapamil-d3 (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].
|
-
- HY-14275S
-
-
- HY-A0251S
-
-
- HY-50936S
-
|
Ecteinascidin 743-d<sub>3sub>; ET-743-d<sub>3sub>
|
Isotope-Labeled Compounds
Reactive Oxygen Species
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .
|
-
- HY-N0156S
-
|
Oleanic acid-d<sub>3sub>; Caryophyllin-d<sub>3sub>
|
Autophagy
HIV
Endogenous Metabolite
|
Cancer
|
|
Oleanolic acid-d3 is the deuterium labeled Oleanolic Acid[1]. Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities[2].
|
-
- HY-166363S
-
|
TRK-100-d<sub>3sub>; ML 1129-d<sub>3sub>
|
Isotope-Labeled Compounds
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
Beraprost-d3 (TRK-100-d3) is deuterium labeled (Rac)-Beraprost. (Rac)-Beraprost ((Rac)-ML 1229) is an orally active prostacyclin analog that inhibits the release of Ca 2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis .
|
-
- HY-B1417S
-
|
Desmethylamitriptyline-d<sub>3sub> (hydrochloride); Desitriptilina-d<sub>3sub> (hydrochloride)
|
Autophagy
Apoptosis
Drug Metabolite
|
Neurological Disease
Cancer
|
|
Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].
|
-
- HY-B2137S
-
|
(S)-Ketoprofen-d<sub>3sub>; Dexketoprofen-d<sub>3sub>
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
S-(+)-Ketoprofen-d3 ((S)-Ketoprofen-d3) is deuterium labeled S-(+)-Ketoprofen. S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
|
-
- HY-103395S
-
|
Methylpropanedioic acid-d<sub>3sub>; Methylmalonate-d<sub>3sub>
|
Endogenous Metabolite
|
Cancer
|
|
Methylmalonic acid-d3 is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer[1][2].
|
-
- HY-B0404AS
-
|
Serazide-d<sub>3sub>; Ro 4-4602-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Benserazide-d3 (hydrochloride) is the deuterium labeled Benserazide hydrochloride. Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC)[1].
|
-
- HY-B0495S5
-
|
LTG-d<sub>3sub>; BW430C-d<sub>3sub>
|
Autophagy
Sodium Channel
|
Neurological Disease
|
|
Lamotrigine-d3 is the deuterium labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].
|
-
- HY-B1140S
-
-
- HY-W004282S1
-
|
Undecanoate-d<sub>3sub>; Hendecanoic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
Fungal
Endogenous Metabolite
Bacterial
|
Infection
|
|
Undecanoic acid-d3 (Undecanoate-d3) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .
|
-
- HY-W759845
-
|
CK-274-d<sub>3sub>; CK-3773274-d<sub>3sub>
|
Isotope-Labeled Compounds
Myosin
|
Cardiovascular Disease
|
|
Aficamten-d3 (CK-274-d3) is deuterium labeled Aficamten. Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM) .
|
-
- HY-B0109AS
-
|
L671152-d<sub>3sub> hydrochloride; MK507-d<sub>3sub> hydrochloride
|
Carbonic Anhydrase
Isotope-Labeled Compounds
|
Others
|
Dorzolamide-d3 hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .
|
-
- HY-N0682S
-
|
Pyridoxol-d<sub>3sub> hydrochloride; Vitamin B6-d<sub>3sub> hydrochloride
|
Endogenous Metabolite
Keap1-Nrf2
|
Neurological Disease
|
|
Pyridoxine-d3 (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
|
-
- HY-W703549
-
|
INCB007839-d<sub>3sub>; INCB7839-d<sub>3sub>
|
Isotope-Labeled Compounds
MMP
|
Cancer
|
|
Aderbasib-d3 (INCB007839-d3) is deuterium labeled Aderbasib. Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2 +?breast cancer, gliomas, et al .
|
-
- HY-B0218S
-
|
Tetrahydrolipstatin-d<sub>3sub>; Ro-18-0647-d<sub>3sub>
|
Isotope-Labeled Compounds
Fatty Acid Synthase (FASN)
Apoptosis
|
Metabolic Disease
|
|
Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .
|
-
- HY-15315S1
-
|
LY3009104-d<sub>3sub>; INCB028050-d<sub>3sub>
|
JAK
|
Inflammation/Immunology
|
|
Baricitinib-d3 is the deuterium labeled Baricitinib. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
|
-
- HY-Y1002S
-
|
3-Hydroxypropyl methyl sulfide-d<sub>3sub>; 3-Methylmercapto-1-propanol-d<sub>3sub>; 4-Thiapentan-1-ol-d<sub>3sub>; gamma-Hydroxypropyl methyl sulfide-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Methionol-d3 is deuterated labeled ((3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl)-L-asparagine.
|
-
- HY-B0141S
-
|
β-Estradiol-d<sub>3sub>; 17β-Estradiol-d<sub>3sub>; 17β-Oestradiol-d<sub>3sub>
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
|
Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
|
-
- HY-Y1298S1
-
|
Acetoacetate methyl ester-d<sub>3sub>; Methyl 3-oxobutanoate-d<sub>3sub>; Methyl acetoacetate-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Methyl acetylacetate-d3 (Acetoacetate methyl ester-d3) is a deuterium labeled Methyl acetylacetate (HY-Y1298). Methyl acetylacetate is an endogenous metabolite .
|
-
- HY-N0488S
-
|
Leurocristine-d<sub>3sub> sulfate; NSC-67574-d<sub>3sub> sulfate; 22-Oxovincaleukoblastine-d<sub>3sub> sulfate
|
Isotope-Labeled Compounds
Microtubule/Tubulin
Apoptosis
|
Cancer
|
|
Vincristine-d3 (sulfate)is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1][2].
|
-
- HY-B0021S1
-
|
Ro 21-9738-d<sub>3sub>; 5-Fluoro-5'-deoxyuridine-d<sub>3sub>; 5'-DFUR-d<sub>3sub>
|
Thymidylate Synthase
Isotope-Labeled Compounds
|
Cancer
|
|
Doxifluridine-d3 is deuterated labeled Doxifluridine (HY-B0021). Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs .
|
-
- HY-14649S5
-
|
Vitamin A acid-d<sub>3sub>; all-trans-Retinoic acid-d<sub>3sub>; ATRA-d<sub>3sub>
|
Isotope-Labeled Compounds
RAR/RXR
PPAR
Endogenous Metabolite
Autophagy
|
Cancer
|
|
Retinoic acid-d3 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .
|
-
- HY-N0488S1
-
|
Leurocristine-d<sub>3sub>-ester sulfate; NSC-67574-d<sub>3sub>-ester sulfate; 22-Oxovincaleukoblastine-d<sub>3sub>-ester sulfate
|
Microtubule/Tubulin
Apoptosis
|
Cancer
|
|
Vincristine-d3-ester (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1].
|
-
- HY-17504BS2
-
|
ZD 4522-<sub>13sub>C,d<sub>3sub> sodium; X-Plended-<sub>13sub>C,d<sub>3sub> sodium; Crestor-<sub>13sub>C,d<sub>3sub> sodium
|
Autophagy
Bacterial
HMG-CoA Reductase (HMGCR)
Potassium Channel
Isotope-Labeled Compounds
|
Cardiovascular Disease
Metabolic Disease
|
|
Rosuvastatin- 13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
|
-
- HY-Y0084S
-
|
Eudesmic acid-d<sub>3sub>; Trimethylgallic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3,4,5-Trimethoxybenzoic acid-d3 is the deuterium labeled 3,4,5-Trimethoxybenzoic acid[1]. 3,4,5-Trimethoxybenzoic acid (Eudesmic acid;Trimethylgallic Acid) is a benzoic acid derivative. A building block in medicine and organic synthesis.
|
-
- HY-Y0251S
-
-
- HY-B1658BS
-
|
(R)-Frovatriptan-d<sub>3sub> succinate; SB 209509-d<sub>3sub> succinate; VML 251-d<sub>3sub> succinate
|
Isotope-Labeled Compounds
5-HT Receptor
|
Neurological Disease
|
|
Frovatriptan-d3 (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].
|
-
- HY-15027S3
-
|
Mesalamine-d<sub>3sub> disodium; 5-ASA-d<sub>3sub> disodium; Mesalazine-d<sub>3sub> disodium
|
PPAR
NF-κB
Endogenous Metabolite
PAK
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
|
-
- HY-12388AS
-
|
Desmethylclomipramine-d<sub>3sub> (hydrochloride)；Norclomipramine-d<sub>3sub> hydrochloride
|
Drug Metabolite
|
Neurological Disease
|
|
N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]
|
-
- HY-B0479S1
-
|
Thiophenicol-d<sub>3sub>-1; Dextrosulphenidol-d<sub>3sub>-1
|
Isotope-Labeled Compounds
|
Infection
|
|
Thiamphenicol-d3-1 (Thiophenicol-d3-1; Dextrosulphenidol-d3-1) is the deuterium-labeled Thiamphenicol (HY-B0479) . Thiamphenicol (Thiophenicol)，a methyl-sulfonyl derivative of Chloramphenicol，is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit，leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative，Gram-positive aerobic and anaerobic bacteria) .
|
-
- HY-12779S
-
|
HGW-86-d<sub>3sub>; DPX-HGW86-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Infection
|
|
Cyantraniliprole-d3 is the deuterium labeled Cyantraniliprole, which is an insecticide of the ryanoid class.
|
-
- HY-108506S
-
|
BIA 2-005-d<sub>3sub>; GP 47779-d<sub>3sub>
|
Sodium Channel
|
Neurological Disease
|
|
Licarbazepine-d3 is the deuterium labeled Licarbazepine (HY-108506). Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects[1][2].
|
-
- HY-Y1311S
-
|
Hydroxybutanedioic acid-d<sub>3sub>; E 296-d<sub>3sub>
|
Endogenous Metabolite
|
Others
|
|
Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods[1][2].
|
-
- HY-13311S
-
|
BGJ-398-d<sub>3sub>; NVP-BGJ398-d<sub>3sub>
|
FGFR
|
Cancer
|
|
Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively .
|
-
- HY-12053AS
-
|
KW-2307-d<sub>3sub> ditartrate; Nor-5'-anhydrovinblastine-d<sub>3sub> ditartrate
|
Microtubule/Tubulin
Autophagy
|
Cancer
|
|
Vinorelbine-d3 (ditartrate) is the deuterium labeled Vinorelbine ditartrate. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
|
-
- HY-N1366S
-
|
7-Methoxycoumarin-d<sub>3sub>; Methyl umbelliferyl ether-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Herniarin-d3 is the deuterium labeled Boc-Phe-CHO[1].
|
-
- HY-17368S2
-
|
ENA 713-d<sub>3sub> hydrochloride; SDZ-ENA 713-d<sub>3sub> hydrochloride
|
Cholinesterase (ChE)
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Rivastigmine-d3 hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
|
-
- HY-N0680S1
-
-
- HY-B0809S1
-
|
1,3-Dimethylxanthine-d<sub>3sub>; Theo-24-d<sub>3sub>
|
Endogenous Metabolite
Adenosine Receptor
HDAC
TNF Receptor
Interleukin Related
Phosphodiesterase (PDE)
Apoptosis
Isotope-Labeled Compounds
|
Cancer
|
|
Theophylline-d3 is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .
|
-
- HY-B2150S
-
|
4-Hydroxyphenazone-d<sub>3sub>; NSC 174055-d<sub>3sub>
|
Drug Metabolite
Isotope-Labeled Compounds
|
Others
|
|
4-Hydroxyantipyrine-d3 is the deuterium labeled 4-Hydroxyantipyrine. 4-Hydroxyantipyrine is the major metabolite of Antipyrine, can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Antipyrine in the brain[1][2][3].
|
-
- HY-15592AS
-
|
GSK-1265744-d<sub>3sub> sodium; S/GSK1265744-d<sub>3sub> sodium
|
Isotope-Labeled Compounds
HIV Integrase
|
Infection
|
|
Cabotegravir-d3 (sodium) is the deuterium labeled Cabotegravir sodium. Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltr
|
-
- HY-70050AS
-
-
- HY-127165S
-
-
- HY-B0225AS
-
|
L-(-)-α-Methyldopa-d<sub>3sub> hydrochloride; MK-351-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Adrenergic Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Methyldopa-d3 (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].
|
-
- HY-G0007S
-
|
Omeprazole sulfone-d<sub>3sub>; Omeprazole sulphone-d<sub>3sub>
|
Isotope-Labeled Compounds
Drug Metabolite
|
Infection
Cancer
|
|
Omeprazole metabolite Omeprazole sulfone-d3 is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
|
-
- HY-13629S
-
-
- HY-B1178S
-
-
- HY-10163S1
-
|
BIBR 953-d<sub>3sub>; BIBR 953ZW-d<sub>3sub>
|
Thrombin
|
Cardiovascular Disease
|
|
Dabigatran-d3 is the deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].
|
-
- HY-14291S
-
|
LAF237-d<sub>3sub>; NVP-LAF 237-d<sub>3sub>
|
Isotope-Labeled Compounds
Dipeptidyl Peptidase
Ferroptosis
Apoptosis
|
Metabolic Disease
|
|
Vildagliptin-d3 is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity[1][2].
|
-
- HY-14959S
-
|
CDB-3236-d<sub>3sub>; Deacetyl CDB-2914-d<sub>3sub>
|
Isotope-Labeled Compounds
Progesterone Receptor
|
Endocrinology
Cancer
|
|
Ulipristal-d3 (CDB-3236-d3) is deuterium labeled Ulipristal. Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system .
|
-
- HY-15463S2
-
|
STI571-d<sub>3sub> hydrochloride; CGP-57148B-d<sub>3sub> hydrochloride
|
Autophagy
Bcr-Abl
c-Kit
SARS-CoV
PDGFR
|
Cancer
|
|
Imatinib-d3 (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.
|
-
- HY-B0456S3
-
|
Vitamin B2-d<sub>3sub>; E101-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Riboflavin-d3 is the deuterium labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-113468AS
-
|
3-Methoxy-L-tyrosine-d<sub>3sub>; 3-O-Methyl-L-DOPA-d<sub>3sub>
|
Isotope-Labeled Compounds
Drug Metabolite
Interleukin Related
|
Neurological Disease
Inflammation/Immunology
|
|
3-O-Methyldopa-d3 (3-Methoxy-L-tyrosine-d3) is deuterium labeled 3-O-Methyldopa (HY-113468A). 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease .
|
-
- HY-134127S2
-
|
C26:0 methyl ester-d<sub>3sub>; Ceic acid methyl ester-d<sub>3sub>; Ceotic acid methyl ester-d<sub>3sub>; SFE 27:0-d<sub>3sub>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Hexacosanoic acid methyl ester-d3 (C26:0 methyl ester-d3) is deuterium labeled Methyl hexacosanoate. Methyl hexacosanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-B0495S
-
|
LTG-13C<sub>3sub>,d<sub>3sub>; BW430C-13C<sub>3sub>,d<sub>3sub>
|
Sodium Channel
Autophagy
|
Neurological Disease
|
|
Lamotrigine- 13C3,d3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
|
-
- HY-W654130
-
|
Daunomycin-13C,d<sub>3sub>; RP 13057-<sub>13sub>C,d<sub>3sub>; Rubidomycin-<sub>13sub>C,d<sub>3sub>
|
Isotope-Labeled Compounds
Bacterial
ADC Cytotoxin
Apoptosis
Antibiotic
Topoisomerase
Autophagy
DNA/RNA Synthesis
|
Infection
|
|
Daunorubicin- 13C,d3 is 13C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
|
-
- HY-10512S
-
|
AR 0133418-d<sub>3sub>; GSK 3β inhibitor VIII-d<sub>3sub>; AR 014418-d<sub>3sub>
|
Isotope-Labeled Compounds
GSK-3
|
Metabolic Disease
Cancer
|
|
AR-A014418-d3 is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM)[1].
|
-
- HY-Y1069S
-
|
(S)-Hydroxybutanedioic acid-d<sub>3sub>; (S)-E 296-d<sub>3sub>; L-Malic acid-d<sub>3sub>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive[1][2].
|
-
- HY-Y0837S
-
|
(S)-2-Amino-1-propanol-d<sub>3sub>; (S)-2-Aminopropanol-d<sub>3sub>; (S)-Alaninol-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
L-Alaninol-d3 is the deuterium labeled L-Alaninol[1].
|
-
- HY-W700927
-
|
N-Formyl-S-leucine-d<sub>3sub>; N-Formylleucine-d<sub>3sub>; NSC 334321-d<sub>3sub>
|
Isotope-Labeled Compounds
Amino Acid Derivatives
|
Others
|
|
N-Formyl-L-leucine-d3 (N-Formyl-S-leucine-d3) is deuterium labeled N-Formyl-L-leucine. N-Formyl-L-leucine is a leucine derivative .
|
-
- HY-79576S
-
|
Oestrone methyl ether-d<sub>3sub>; 3-O-Methylestrone-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Estrone 3-methyl ether-d3 is the deuterium labeled Estrone 3-methyl ether[1].
|
-
- HY-N0570S1
-
|
DOPET-d<sub>5sub>; 3,4-Dihydroxyphenethyl alcohol-d<sub>5sub>; 3-Hydroxytyrosol-d<sub>5sub>
|
Endogenous Metabolite
Bacterial
Fungal
|
Infection
Inflammation/Immunology
Cancer
|
|
Hydroxytyrosol-d5 is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].
|
-
- HY-N0570S
-
-
- HY-B1716S
-
|
L-5-HTP-d<sub>3sub>; Oxitriptan-d<sub>3sub>
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
L-5-Hydroxytryptophan-d3 is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[2][3][4][5].
|
-
- HY-40354AS
-
-
- HY-Y0219S1
-
-
- HY-B1205S
-
-
- HY-N0086S
-
|
6-Methyladenosine-d<sub>3sub>; N-Methyladenosine-d<sub>3sub>
|
Isotope-Labeled Compounds
Influenza Virus
Endogenous Metabolite
|
Infection
|
|
N6-Methyladenosine-d3 (6-Methyladenosine-d3; N-Methyladenosine-d3) is a deuterium labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.
|
-
- HY-14648S5
-
|
Hexadecadrol-d<sub>3sub>-1; Prednisolone F-d<sub>3sub>-1
|
Isotope-Labeled Compounds
Antibiotic
Autophagy
Glucocorticoid Receptor
SARS-CoV
ADC Cytotoxin
Mitophagy
Complement System
Bacterial
|
Cancer
|
|
Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
|
-
- HY-B0932S
-
|
L-Propionylcarnitine-d<sub>3sub> (chloride); ST-261-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Levocarnitine propionate-d3 (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.
|
-
- HY-Y1275S1
-
|
NMP-d<sub>3sub>; N-Methyl-2-pyrrolidone-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N-Methylpyrrolidone-d3 is the deuterium labeled N-Methylpyrrolidone [1]. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[2][3].
|
-
- HY-B0471S
-
|
(R)-(-)-Phenylephrine-d<sub>3sub> (hydrochloride); L-Phenylephrine-d<sub>3sub> (hydrochloride)
|
Adrenergic Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Phenylephrine-d3 (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
|
-
- HY-B0161AS
-
|
(S)-Duloxetine-d<sub>3sub> (hydrochloride); LY248686-d<sub>3sub> (hydrochloride)
|
Serotonin Transporter
|
Neurological Disease
|
|
Duloxetine-d3 (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].
|
-
- HY-129240S
-
|
Isoacitretin d<sub>3sub>; Ro 13-7652 d<sub>3sub>
|
Drug Metabolite
|
Inflammation/Immunology
|
|
13-cis Acitretin-d3 is a deuterium labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis[1][2].
|
-
- HY-W701918
-
|
Phenpromethamine-d<sub>3sub> hydrochloride; Methyl-(2-phenyl-propyl)-amine-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
Vonedrine-d3 (hydrochloride) is the deuterium labeled Vonedrine (hydrochloride) .
|
-
- HY-B1287S
-
|
(±)-Citalopram hydrobromide-d<sub>3sub>; Lu 10-171-d<sub>3sub>
|
Isotope-Labeled Compounds
Serotonin Transporter
Autophagy
|
Neurological Disease
Cancer
|
|
Citalopram-d3 ((±)-Citalopram-d3) hydrobromide is deuterium labeled Citalopram (hydrobromide). Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
|
-
- HY-150964S
-
|
S-Adenosyl methionine-d<sub>3sub> methylbenzenesulfonate; Ademetionine-d<sub>3sub> methylbenzenesulfonate; AdoMet-d<sub>3sub> methylbenzenesulfonate
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) methylbenzenesulfonate is the deuterium labeled S-Adenosyl-L-methionine methylbenzenesulfonate . S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .
|
-
- HY-14649S6
-
|
Vitamin A acid-d<sub>3sub>-1; all-trans-Retinoic acid-d<sub>3sub>-1; ATRA-d<sub>3sub>-1
|
Isotope-Labeled Compounds
RAR/RXR
PPAR
Endogenous Metabolite
Autophagy
|
Metabolic Disease
Cancer
|
|
Retinoic acid-d3-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .
|
-
- HY-G0003S1
-
|
P88-d<sub>3sub>; Hydroxy Iloperidone-d<sub>3sub>
|
Drug Metabolite
|
Others
|
|
Iloperidone metabolite Hydroxy Iloperidone-d3 is the deuterium labeled Iloperidone metabolite Hydroxy Iloperidone[1].
|
-
- HY-B0130AS
-
|
Perindopril-d<sub>3sub> tert-butylamine salt; S-9490-d<sub>3sub> erbumine
|
NF-κB
STAT
Sirtuin
Angiotensin-converting Enzyme (ACE)
Isotope-Labeled Compounds
|
Cardiovascular Disease
Cancer
|
|
Perindopril-d3 (erbumine) is deuterated labeled Perindopril (erbumine) (HY-B0130A). Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .
|
-
- HY-I0746S
-
|
m-Aminobenzoic acid-d<sub>4sub>; 3ABA-d<sub>4sub>
|
Endogenous Metabolite
|
Others
|
|
3-Aminobenzoic acid-d4 is the deuterium labeled 3-Aminobenzoic acid[1].
|
-
- HY-B0352BS
-
|
(R)-Org3770 d<sub>3sub>; (R)-6-Azamianserin d<sub>3sub>
|
Isotope-Labeled Compounds
5-HT Receptor
|
Neurological Disease
|
|
(R)-Mirtazapine-d3 is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].
|
-
- HY-W154267S
-
|
β-Aminoisobutyric acid-d<sub>3sub> hydrochloride; BAIBA-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
3-Aminoisobutyric acid-d3 (hydrochloride) is the deuterium labeled DL-Histidine[1].
|
-
- HY-131932S
-
|
L-706803-d<sub>3sub> hydrochloride; N-Deethyldorzolamide hydrochloride-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N-Desethyl-dorzolamide-d3 hydrochloride is deuterated labeled N-Desethyl-dorzolamide.
|
-
- HY-15029S1
-
-
- HY-B0352AS
-
|
(S)-Org3770 d<sub>3sub>; (S)-6-Azamianserin d<sub>3sub>
|
5-HT Receptor
|
Neurological Disease
|
|
(S)-Mirtazapine-d3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].
|
-
- HY-B0801S4
-
|
MDL-16455-d<sub>3sub>-1; Terfenadine carboxylate-d<sub>3sub>-1
|
Histamine Receptor
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Fexofenadine-d3-1 fumarate is deuterated labeled Fexofenadine (HY-B0801). Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research .
|
-
- HY-B1342S5
-
-
- HY-78131S
-
-
- HY-B1057S2
-
|
Fenazoxine-d<sub>3sub>
|
β-catenin
|
Neurological Disease
|
|
Nefopam-d3 is a deuterium labeled Nefopam (Fenazoxine). Nefopam is a centrally-acting but non-opioid analgesic drug, and Nefopam targets β-catenin protein level in mesenchymal cells[1][2].
|
-
- HY-N6608S
-
|
Eserine-d<sub>3sub>
|
Isotope-Labeled Compounds
Cholinesterase (ChE)
|
Neurological Disease
|
|
Physostigmine-d3 is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].
|
-
- HY-D0205AS2
-
|
Carbocysteine-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Infection
Inflammation/Immunology
|
|
Carbocisteine-d3 (Carbocysteine-d3) is deuterium labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research .
|
-
- HY-78131CS
-
|
(±)-Ibuprofen-d<sub>3sub> sodium
|
Apoptosis
COX
Isotope-Labeled Compounds
Parasite
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Ibuprofen-d3 ((±)-Ibuprofen-d3) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
|
-
- HY-124920S
-
-
- HY-76299S2
-
-
- HY-N0083S
-
-
- HY-B0439S1
-
|
Sulphadoxine d<sub>3sub>
|
Parasite
Antibiotic
|
Infection
|
|
Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].
|
-
- HY-B1057S
-
|
Fenazoxine-d<sub>3sub> hydrochloride
|
β-catenin
|
Neurological Disease
|
|
Nefopam-d3 (hydrochloride) is the deuterium labeled Nefopam hydrochloride. Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2].
|
-
- HY-B0330BS1
-
|
(-)-Ofloxacin-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Topoisomerase
DNA/RNA Synthesis
Orthopoxvirus
|
Infection
Cancer
|
|
Levofloxacin-d3 ((-)-Ofloxacin-d3) hydrochlorideis deuterium labeled Levofloxacin (hydrochloride). Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrochloride shows anti-orthopoxvirus activity .
|
-
- HY-107469S1
-
-
- HY-B1328S1
-
|
Pyridoxol-d<sub>3sub>
|
NF-κB
|
Neurological Disease
|
|
Pyridoxine-d3 is a deuterium labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway .
|
-
- HY-N0504S2
-
-
- HY-N0583S3
-
-
- HY-107469S
-
|
Pyridoxaldehyde-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
Pyridoxal-d3 (hydrochloride) is the deuterium labeled Pyridoxal hydrochloride[1].
|
-
- HY-B0251S
-
|
Epoxymexrenone-d<sub>3sub>
|
Mineralocorticoid Receptor
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Eplerenone-d3 is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch[1][2].
|
-
- HY-77956S4
-
|
Deoxyribose-d<sub>3sub>
|
Endogenous Metabolite
|
Others
|
|
Thyminose-d3 is the deuterium labeled Thyminose. Thyminose is an endogenous metabolite[1].
|
-
- HY-W740078
-
-
- HY-113739S
-
|
DCIT-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
Desmethylcitalopram-d3 (hydrochloride) is the deuterium labeled Desmethylcitalopram hydrochloride[1].
|
-
- HY-N0088S
-
|
Acetovanillone-d<sub>3sub>
|
Apoptosis
Autophagy
|
Cancer
|
|
Apocynin-d3 is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].
|
-
- HY-N0415S
-
|
Trigonelline-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
HSV
Bacterial
Fungal
|
Infection
Metabolic Disease
Cancer
|
|
Trigonelline-d3 (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
|
-
- HY-15206S1
-
|
Glyburide-d<sub>3sub>
|
Potassium Channel
Mitochondrial Metabolism
Autophagy
CFTR
P-glycoprotein
|
Metabolic Disease
|
|
Glyburide-d3 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
|
-
- HY-B0147S1
-
-
- HY-B0188S
-
-
- HY-W700770
-
|
Dodecyltrimethylammonium-d<sub>3sub> chloride
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
DTAC-d3 (Dodecyltrimethylammonium-d3 chloride) is the deuterium labeled DTAC (HY-W096983). DTAC is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W016034S
-
|
p-Acetamidophenyl β-D-glucuronide-d<sub>3sub> sodium salt; p-AAPG-d<sub>3sub> sodium salt
|
Isotope-Labeled Compounds
|
Others
|
|
Acetaminophen glucuronide-d3 sodium salt is the deuterium labeled Acetaminophen glucuronide sodium salt.
|
-
- HY-18569S3
-
|
Indole-3-acetic acid-d<sub>7sub>; 3-IAA-d<sub>7sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Indoleacetic acid-d7 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
|
-
- HY-15592S2
-
|
GSK-1265744-d<sub>3sub>-1; S/GSK1265744-d<sub>3sub>-1
|
Isotope-Labeled Compounds
HIV Integrase
|
Infection
|
|
Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research
|
-
- HY-18569S1
-
|
Indole-3-acetic acid-d<sub>4sub>; 3-IAA-d<sub>4sub>
|
Isotope-Labeled Compounds
Molecular Glues
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Indoleacetic acid-d4 (Indole-3-acetic acid-d4; 3-IAA-d4) is the deuterium labeled 3-Indoleacetic acid (HY-18569) . 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
|
-
- HY-18569S
-
|
Indole-3-acetic acid-d<sub>5sub>; 3-IAA-d<sub>5sub>
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
3-Indoleacetic acid-d5 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid-d5 can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates .
|
-
- HY-N0679S
-
|
ALK-001; Retinol acetate-d<sub>3sub>; Vitamin A acetate-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Retinyl acetate-d3 (ALK-001) is a deuterated Vitamin A. Retinyl acetate-d3 can be used for research of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) .
|
-
- HY-B0648S
-
|
17α-Hydroxy-6α-methylprogesterone-d<sub>3sub>; U8840-d<sub>3sub>
|
Progesterone Receptor
|
Endocrinology
|
|
Medroxyprogesterone-d3 is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
|
-
- HY-N0707S
-
|
1-Methyl-L-tryptophan-d<sub>3sub>; (S)-NLG-8189-d<sub>3sub>
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
|
(S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].
|
-
- HY-112582S
-
|
1-Methylpseudouridine-d<sub>3sub>; N1-methyl-pseudouridine-d<sub>3sub>
|
Nucleoside Antimetabolite/Analog
|
Cancer
|
|
N1-Methylpseudouridine-d3 is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
|
-
- HY-B0300S
-
-
- HY-Y1770S
-
|
5-Bromo-2-pyridinamine-d<sub>3sub>; 2-Amino-5-bromopyridine-d<sub>3sub>; 5-Bromo-2-aminopyridine-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Amino-5-bromopyridine-d3 is the deuterium labeled 2-Amino-5-bromopyridine[1].
|
-
- HY-16938S1
-
|
5'-(Methylthio)-5'-deoxyadenosine-d<sub>3sub>; 5'-Deoxy-5'-(methylthio)adenosine-d<sub>3sub>; 5'-S-Methyl-5'-thioadenosine-d<sub>3sub>
|
Apoptosis
Parasite
Endogenous Metabolite
|
Inflammation/Immunology
|
|
5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine[1]. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2][3][4].
|
-
- HY-W000854S
-
|
3-Methoxyphenylboronic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Methoxybenzeneboronic acid-d3 is the deuterium labeled 3-Methoxybenzeneboronic acid (HY-W000854). 3-Methoxybenzeneboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-135794S
-
|
11-KDHT-d<sub>3sub>; 5α-Dihydro-11-keto testosterone-d<sub>3sub>
|
Isotope-Labeled Compounds
Androgen Receptor
|
Endocrinology
|
|
11-Ketodihydrotestosterone-d3 is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells[1][2].
|
-
- HY-144856S1
-
|
(6R)-BH4-d<sub>3sub>; (6R)-Tetrahydro-L-biopterin-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Sapropterin-d3 ((6R)-BH4-d3) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .
|
-
- HY-B1716S1
-
|
L-5-HTP-d<sub>3sub>-1; Oxitriptan-d<sub>3sub>-1
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-5-Hydroxytryptophan-d3-1 is the deuterium labeled L-5-Hydroxytryptophan[1]. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[2]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[3][4][5][6].
|
-
- HY-W017387S
-
|
Sodium 4-methyl-2-oxopentanoate-d<sub>3sub>; 2-Ketoisocaproic acid-d<sub>3sub> sodium salt
|
Isotope-Labeled Compounds
|
Others
|
|
Sodium α-ketoisocaproate-d3 is the deuterium labeled Sodium α-ketoisocaproate[1].
|
-
- HY-17459S
-
|
(S)-(+)-Clopidogrel bisulfate-d<sub>3sub>; (S)-(+)-Clopidogrel-d<sub>3sub> hydrogen sulfate
|
P2Y Receptor
Cytochrome P450
|
Cardiovascular Disease
|
|
Clopidogrel-d3 (hydrogen sulfate) is the deuterium labeled Clopidogrel hydrogen sulfate[1]. Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[2][3][4][5][6].
|
-
- HY-119521S
-
|
KOE-1173-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
Neurological Disease
|
|
Mexiletine-d3 (KOE-1173-d3) is deuterium labeled Mexiletine. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
|
-
- HY-18204S1
-
|
CGP 48933-d<sub>3sub>
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Valsartan-d3 is the deuterium labeled Valsartan[1]. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[2].
|
-
- HY-12085S3
-
-
- HY-A0168S
-
|
CVT-3146-d<sub>3sub>
|
Adenosine Receptor
|
Cardiovascular Disease
Cancer
|
|
Regadenoson-d3 is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with Kis of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents[1][2][3].
|
-
- HY-B1743S
-
|
CL13900-d<sub>3sub>
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Puromycin-d3 is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.
|
-
- HY-N1380S1
-
-
- HY-50904S
-
|
BIBF 1120-d<sub>3sub>
|
PDGFR
VEGFR
FGFR
|
Cancer
|
|
Nintedanib-d3 is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
|
-
- HY-N0370S
-
-
- HY-14541S
-
|
LY170053-d<sub>3sub>
|
5-HT Receptor
Dopamine Receptor
mAChR
Adrenergic Receptor
Autophagy
Mitophagy
Apoptosis
|
Neurological Disease
Cancer
|
|
Olanzapine-d3 is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].
|
-
- HY-17016S1
-
|
GS 4104-d<sub>3sub> phosphate
|
Isotope-Labeled Compounds
Influenza Virus
|
Infection
|
|
Oseltamivir-d3 (phosphate)eis the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
|
-
- HY-B0421S
-
-
- HY-B0223S
-
|
SKF-62979-d<sub>3sub>
|
Parasite
|
Infection
|
|
Albendazole-d3 is the deuterium labeled Albendazole, which is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations[1].
|
-
- HY-10448S1
-
-
- HY-10065S1
-
|
AG-013736-d<sub>3sub>
|
VEGFR
|
Cancer
|
|
Axitinib-d3 (AG-013736-d3) is deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively[1].
|
-
- HY-B0623AS2
-
|
SKF 101468-d<sub>3sub> hydrochloride
|
Dopamine Receptor
|
Neurological Disease
|
|
Ropinirole-d3 (hydrochloride) is the deuterium labeled Ropinirole hydrochloride[1]. Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[2][3].
|
-
- HY-B0559S
-
|
BRL14777-d<sub>3sub>
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
|
Nabumetone-d3 is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.
|
-
- HY-B0827S
-
|
MTI-446-d<sub>3sub>
|
nAChR
Parasite
|
Infection
Cardiovascular Disease
|
|
Dinotefuran-d3 is the deuterium labeled Dinotefuran[1]. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors[2].
|
-
- HY-123230S1
-
-
- HY-A0093S1
-
|
KOE-1173-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Sodium Channel
|
Cardiovascular Disease
|
|
Mexiletine-d3 (hydrochloride) is deuterium labeled Mexiletine (hydrochloride). Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1][2].
|
-
- HY-121046S
-
|
Sch 14714-d<sub>3sub>
|
COX
|
Inflammation/Immunology
|
|
Flunixin-d3 is the deuterium labeled Flunixin. Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity[1][2].
|
-
- HY-13904S
-
|
HHGV678-d<sub>3sub>
|
Isotope-Labeled Compounds
Bcr-Abl
c-Kit
PDGFR
|
Cancer
|
|
Flumatinib-d3 is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1].
|
-
- HY-115364S
-
-
- HY-W757743
-
|
ACP-196-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Acalabrutinib-d3 (ACP-196-d3) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).
|
-
- HY-B0623S1
-
|
SKF 101468-d<sub>3sub>
|
Isotope-Labeled Compounds
Dopamine Receptor
|
Neurological Disease
|
|
Ropinirole-d3 (SKF 101468-d3) is deuterium labeled Ropinirole. Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease .
|
-
- HY-W006398S
-
-
- HY-B0452S1
-
-
- HY-101566S
-
|
BAY 1895344-d<sub>3sub>
|
ATM/ATR
|
Cancer
|
|
Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity .
|
-
- HY-14957S
-
|
T-3912-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Ozenoxacin-d3 is the deuterium-labeled Ozenoxacin (HY-14957). Ozenoxacin-d3 is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.
|
-
- HY-70037S
-
|
AMG 073-d<sub>3sub>
|
CaSR
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Cinacalcet-d3 is the deuterium labeled Cinacalcet. Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
|
-
- HY-B0008S
-
-
- HY-W754911
-
|
BLU-285-d<sub>3sub>
|
Isotope-Labeled Compounds
PDGFR
c-Kit
|
Cancer
|
|
Avapritinib-d3 (BLU-285-d3) is deuterium labeled Avapritinib. Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 .
|
-
- HY-133771AS
-
|
Desmethyldoxepin-d<sub>3sub> (hydrochloride)
|
Drug Metabolite
|
Neurological Disease
|
|
Nordoxepin-d3 (hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride (HY-B0725), which is an orally active tricyclic antidepressant[1].
|
-
- HY-17395AS1
-
|
TDT 067-d<sub>3sub>
|
Isotope-Labeled Compounds
Antibiotic
Fungal
Bacterial
|
Infection
|
|
Terbinafine-d3 (TDT 067-d3) is deuterium labeled Terbinafine. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-10208S2
-
|
GW786034-d<sub>3sub>
|
Isotope-Labeled Compounds
Autophagy
VEGFR
c-Kit
PDGFR
FGFR
|
Cancer
|
|
Pazopanib-d3 (GW786034-d3) is deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively .
|
-
- HY-121246S
-
|
AKF-PD-d<sub>3sub>
|
Isotope-Labeled Compounds
Akt
PI3K
|
Inflammation/Immunology
|
|
Fluorofenidone-d3 is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].
|
-
- HY-Y0958S
-
|
O-Methylhydroxylamine-d<sub>3sub> hydrochloride
|
DNA/RNA Synthesis
Apoptosis
Isotope-Labeled Compounds
|
Cancer
|
|
Methoxyamine-d3 (O-Methylhydroxylamine-d3) hydrochloride is the deuterium labeled Methoxyamine hydrochloride. Methoxyamine hydrochloride is an orally active and potent base excision repair (BER) inhibitor .
|
-
- HY-B1111S1
-
-
- HY-16060S1
-
|
ARN-509-d<sub>3sub>
|
Androgen Receptor
|
Cancer
|
|
Apalutamide-d3 is the deuterium labeled Apalutamide[1]. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[2].
|
-
- HY-15029S
-
-
- HY-14398S1
-
|
SC 58635-d<sub>3sub>
|
COX
|
Inflammation/Immunology
Cancer
|
|
Celecoxib-d3 is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].
|
-
- HY-90009S
-
|
IC-351-d<sub>3sub>
|
Phosphodiesterase (PDE)
|
Cardiovascular Disease
|
|
Tadalafil-d3 is the deuterium labeled Nortadalafil. Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
|
-
- HY-17474S
-
|
SC 69124-d<sub>3sub>
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
|
Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
|
-
- HY-12643S
-
|
MK-397-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Infection
Cancer
|
|
Eprinomectin-d3 (MK-397-d3) is the deuterium-labeled Eprinomectin (HY-12643). Eprinomectin is a type of avermectin. Eprinomectin，as a broad-spectrum fungicide，has insecticidal，insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity .
|
-
- HY-10582S
-
|
dl-Flurbiprofen-d<sub>3sub>
|
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Flurbiprofen-d3 is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
|
-
- HY-B1743AS
-
|
CL13900-d<sub>3sub> dihydrochloride
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Puromycin-d3 (dihydrochloride) is the deuterium labeled Puromycin dihydrochloride. Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis[1].
|
-
- HY-B0331S1
-
-
- HY-B0361S
-
|
SC-18862-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Aspartame-d3 is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
|
-
- HY-14289S
-
|
SKF-92334-d<sub>3sub>
|
Histamine Receptor
|
Endocrinology
Cancer
|
|
Cimetidine-d3 is the deuterium labeled Cimetidine. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is an inverse agonist. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].
|
-
- HY-B0561S1
-
|
SC9420-d<sub>3sub>
|
Mineralocorticoid Receptor
Androgen Receptor
Autophagy
|
Metabolic Disease
Cancer
|
|
Spironolactone-d3 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].
|
-
- HY-14779S3
-
-
- HY-13626S
-
|
ES-285-d<sub>3sub>
|
Isotope-Labeled Compounds
PKC
Apoptosis
|
Cancer
|
|
Spisulosine-d3 (ES-285-d3) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .
|
-
- HY-B0451AS4
-
-
- HY-14283S1
-
|
NND 502-d<sub>3sub>
|
Isotope-Labeled Compounds
Antibiotic
Fungal
|
Infection
|
|
Luliconazole-d3 (NND 502-d3) is deuterium labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .
|
-
- HY-B0368S
-
|
SQ 14225-d<sub>3sub>
|
Isotope-Labeled Compounds
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
Captopril-d3 is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM[1][2][3].
|
-
- HY-W740028
-
|
ME 1206-d<sub>3sub>
|
Isotope-Labeled Compounds
Bacterial
Beta-lactamase
|
Infection
Inflammation/Immunology
|
|
Cefditoren-d3 (sodium) (ME 1206-d3) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
|
-
- HY-W747682
-
-
- HY-W714177S
-
|
Atraton-desisopropyl-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Desisopropylatraton-d3 (Atraton-desisopropyl-d3) is deuterium labeled N2-Ethyl-6-methoxy-1,3,5-triazine-2,4-diamine .
|
-
- HY-17514S1
-
-
- HY-14956S
-
|
TG-873870-d<sub>3sub>
|
Bacterial
|
Inflammation/Immunology
|
|
Nemonoxacin-d3 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].
|
-
- HY-B0276S
-
|
2-ethylthioisonicotinamide-d<sub>3sub>
|
Bacterial
Antibiotic
|
Infection
|
|
Ethionamide-d3 is the deuterium labeled Ethionamide. Ethionamide (2-ethylthioisonicotinamide) is an antibiotic used in the treatment of tuberculosis.
|
-
- HY-14771S
-
-
- HY-B1398S
-
|
4-Aminoantipyrine-d<sub>3sub>
|
Isotope-Labeled Compounds
COX
Drug Metabolite
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Ampyrone-d3 is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .
|
-
- HY-B0253S
-
|
CP-16171 d<sub>3sub>
|
COX
|
Inflammation/Immunology
Cancer
|
|
Piroxicam-d3 is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively [1].
|
-
- HY-N0471S
-
|
Daturine-d<sub>3sub>
|
mAChR
|
Neurological Disease
|
|
L-Hyoscyamine-d3 is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].
|
-
- HY-W713365
-
|
SB-497115-d<sub>3sub>
|
Isotope-Labeled Compounds
Thrombopoietin Receptor
Apoptosis
Bacterial
|
Infection
Cardiovascular Disease
Cancer
|
|
Eltrombopag-d3 (SB-497115-d3) is deuterium labeled Eltrombopag. Eltrombopag (SB-497115) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag can be used for the research of cardiovascular. Eltrombopag also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag can induce apoptosis in hepatocellular carcinomab (HCC) as well .
|
-
- HY-15284S1
-
|
PCR 4099-d<sub>3sub>
|
P2Y Receptor
|
Cardiovascular Disease
|
|
Prasugrel-d3 is the deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[1].
|
-
- HY-10234S
-
|
AZD0530-d<sub>3sub>
|
Src
|
Infection
|
|
Saracatinib-d3 (AZD0530-d3) (ZG5129) is the deuterium-labeled analog of Saracatinib (HY-10234). Saracatinib-d3 is an inhibitor of the Src kinase, which can inhibit severe sepsis caused by bacterial or various microbial infections .
|
-
- HY-15025S
-
-
- HY-10564S
-
|
MCI-9042-d<sub>3sub>
|
Isotope-Labeled Compounds
5-HT Receptor
|
Cardiovascular Disease
|
|
Sarpogrelate-d3 (hydrochloride) is the deuterium labeled Sarpogrelate hydrochloride. Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis[1][2][3].
|
-
- HY-17038S2
-
|
S-20098-d<sub>3sub>
|
Melatonin Receptor
5-HT Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
Agomelatine-d3 is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].
|
-
- HY-15030S1
-
|
(S)-Naproxen-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Naproxen-d3 is the deuterium labeled Naproxen. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-101664S
-
-
- HY-N1914S
-
|
L-(+)-Ergothioneine-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Ergothioneine-d3 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
|
-
- HY-114277S2
-
|
AMG-510-d<sub>3sub>
|
Isotope-Labeled Compounds
Ras
|
Cancer
|
|
Sotorasib-d3 (AMG-510-d3) is deuterium labeled Sotorasib. Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C?mutated locally advanced or metastatic non?small cell lung cancer (NSCLC) .
|
-
- HY-18342S
-
|
MK-647-d<sub>3sub>
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
|
Diflunisal-d3 is the deuterium labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
|
-
- HY-B0260S
-
-
- HY-10394S
-
|
PNU-100766-d<sub>3sub>
|
Bacterial
Antibiotic
|
Infection
|
|
Linezolid-d3 is a deuterium labeled Linezolid (PNU-100766). Linezolid is a synthetic antibiotic that acts by inhibiting the initiation of bacterial protein synthesis[1].
|
-
- HY-B0497S2
-
|
BAY2353-d<sub>3sub>
|
Isotope-Labeled Compounds
Antibiotic
STAT
Parasite
|
Infection
Cancer
|
|
Niclosamide-d3 (BAY2353-d3) is deuterium labeled Niclosamide. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .
|
-
- HY-15762S
-
-
- HY-B0161ES
-
|
(Rac)-Duloxetine-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Serotonin Transporter
|
Neurological Disease
|
|
(±)-Duloxetine-d3 (hydrochloride) is deuterium labeled (±)-Duloxetine (hydrochloride). (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder research[1].
|
-
- HY-10528S
-
|
ABR-215050-d<sub>3sub>
|
HDAC
Isotope-Labeled Compounds
|
Cancer
|
|
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn 2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor .
|
-
- HY-W705479
-
|
GW786034-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Autophagy
PDGFR
FGFR
c-Fms
VEGFR
c-Kit
|
Cancer
|
|
Pazopanib-d3 (hydrochloride) (GW786034-d3 (hydrochloride)) is deuterium labeled Pazopanib (Hydrochloride). Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
|
-
- HY-14957AS
-
|
T-3912-d<sub>3sub> hydrochloride
|
Antibiotic
Bacterial
|
Inflammation/Immunology
|
|
Ozenoxacin-d3 (hydrochloride) is the deuterium labeled Ozenoxacin hydrochloride. Ozenoxacin hydrochloride is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections[1][2][3].
|
-
- HY-W012480S
-
-
- HY-B0621S
-
-
- HY-10984S1
-
|
CC-4047-d<sub>3sub>
|
Ligands for E3 Ligase
Molecular Glues
Apoptosis
|
Cancer
|
|
Pomalidomide-d3 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors[1][2].
|
-
- HY-N1952S
-
|
iso-Eugenol-d<sub>3sub>
|
Bacterial
Isotope-Labeled Compounds
|
Infection
|
|
Isoeugenol-d3 is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
|
-
- HY-W014612S
-
-
- HY-A0039S
-
|
UK-116044-d<sub>3sub>
|
5-HT Receptor
|
Neurological Disease
|
|
Eletriptan-d3 is the deuterium labeled Eletriptan hydrobromide. Eletriptan hydrobromide is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively[1][2].
|
-
- HY-16774S
-
|
BAY1021189-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
Vericiguat-d3 (BAY1021189-d3) hydrochloride is a deuterated Vericiguat with tracer functionality. Vericiguat is an orally available stimulator of guanylate cyclase .
|
-
- HY-105182S1
-
|
LY-246708-d<sub>3sub>
|
Isotope-Labeled Compounds
mAChR
|
Neurological Disease
|
|
Xanomeline-d3 (LY-246708-d3) is deuterium labeled Xanomeline. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia .
|
-
- HY-141776S
-
|
Ufiprazole-d<sub>3sub>
|
Drug Metabolite
|
Others
|
|
Omeprazole sulfide-d3 is the deuterium labeled Omeprazole sulfide. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.
|
-
- HY-108251S
-
-
- HY-A0014S1
-
-
- HY-14281S
-
|
Win 24540-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Trilostane-d3 is the deuterium-labeled Trilostane (HY-14281). Trilostane-d3 (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane-d3 is a synthetic nonhormonal steroid. Trilostane-d3 can be used for the research of breast cancer and prostate cancer .
|
-
- HY-76200S
-
|
UK-109496-d<sub>3sub>
|
Fungal
|
Infection
|
|
Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].
|
-
- HY-B0334S
-
|
CP45899-d<sub>3sub>
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Sulbactam-d3 (CP45899-d3) is deuterium labeled Sulbactam. Sulbactam (CP45899) is a competitive, irreversible beta-lactamase inhibitor. Sulbactam shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .
|
-
- HY-32735S
-
|
PG490-d<sub>3sub>
|
Isotope-Labeled Compounds
NF-κB
Apoptosis
|
Cancer
|
|
Triptolide-d3 is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].
|
-
- HY-105028S
-
|
CP-66248-d<sub>3sub>
|
COX
|
Inflammation/Immunology
|
|
Tenidap-d3 is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor[3].
|
-
- HY-B0106AS
-
-
- HY-17034BS
-
-
- HY-12515AS
-
|
YC-93-d<sub>3sub>
|
Calcium Channel
|
Neurological Disease
|
|
Nicardipine-d3 (hydrochloride) (YC-93 D3) is the deuterium labeled Nicardipine hydrochloride. Nicardipine hydrochloride is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure[1].
|
-
- HY-B0374S2
-
-
- HY-10353AS
-
|
MK 0518-d<sub>3sub> potassium
|
Isotope-Labeled Compounds
HIV Integrase
HIV
|
Infection
|
|
Raltegravir-d3 (potassium) is the deuterium labeled Raltegravir potassium. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection[1][2].
|
-
- HY-W015913S1
-
|
Sodium pyruvate-d<sub>3sub>
|
Endogenous Metabolite
Reactive Oxygen Species
|
Metabolic Disease
|
|
Sodium 2-oxopropanoate-d3 is the deuterium labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].
|
-
- HY-17395S
-
|
TDT 067-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Fungal
Bacterial
Antibiotic
|
Infection
|
|
Terbinafine-d3 (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].
|
-
- HY-W099696S1
-
-
- HY-Y0626S
-
|
Ethanehydrazonic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Acetohydrazide-d3 (Ethanehydrazonic acid-d3) is deuterium labeled Acetohydrazide. Acethydrazide is an organic building that undergo catalytic hydrogenation to produce N′-methyl acethydrazide (MAH) .
|
-
- HY-B0113S4
-
|
H 16868-d<sub>3sub> sodium
|
Autophagy
Phospholipase
Proton Pump
Bacterial
Isotope-Labeled Compounds
|
Infection
Metabolic Disease
Cancer
|
|
Omeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
|
-
- HY-W007692S
-
|
2-Acetylpyrazine-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Acetylpyrazine-d3 is deuterated labeled Linalyl acetate (HY-N6948). Linalyl acetate is the principal components of many plant essential oils with potentially anti-inflammatory activity .
|
-
- HY-W008216S
-
|
Hydroxy Dimetridazole-d<sub>3sub>
|
Drug Metabolite
Isotope-Labeled Compounds
Parasite
|
Infection
|
|
HMMNI-d3 (Hydroxy Dimetridazole-d3) is deuterium labeled HMMNI (HY-W008216). HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazol (HY-B1244). Dimetridazole is a nitroimidazole class agent that combats protozoan infections .
|
-
- HY-17502S1
-
-
- HY-14539S3
-
|
HF 1854-d<sub>3sub>
|
Isotope-Labeled Compounds
5-HT Receptor
Adrenergic Receptor
Dopamine Receptor
mAChR
|
Neurological Disease
Cancer
|
|
Clozapine-d3 (HF 1854-d3) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) .
|
-
- HY-B0504S
-
-
- HY-B0777S
-
|
CL-301423-d<sub>3sub>
|
Isotope-Labeled Compounds
BCRP
Parasite
Antibiotic
P-glycoprotein
|
Infection
|
|
Moxidectin-d3 (CL-301423-d3) is deuterium labeled Moxidectin. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk .
|
-
- HY-B0125S
-
-
- HY-W759629
-
|
LOXO-292-d<sub>3sub>
|
Isotope-Labeled Compounds
RET
|
Cancer
|
|
Selpercatinib-d3 (LOXO-292-d3) is deuterium labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity .
|
-
- HY-17373S2
-
-
- HY-B0227S
-
|
RP-19583-d<sub>3sub>
|
COX
Apoptosis
|
Inflammation/Immunology
|
|
Ketoprofen-d3 is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
|
-
- HY-106141S
-
-
- HY-B0656AS1
-
|
LY307640-d<sub>3sub> sodium
|
Isotope-Labeled Compounds
Proton Pump
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Rabeprazole-d3 (sodium)mis the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].
|
-
- HY-70037AS
-
-
- HY-B0192S2
-
-
- HY-17413S1
-
|
Azidothymidine-13C,d<sub>3sub>; AZT-13C,d<sub>3sub>; ZDV-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
HIV
|
Infection
Cancer
|
|
Zidovudine- 13C,d3 is the 13C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
|
-
- HY-Y1088S2
-
|
3-Phenylpropionic acid-d<sub>9sub>; 3-Phenylpropanoic acid-d<sub>9sub>; 3-Phenyl-n-propionic acid-d<sub>9sub>
|
Endogenous Metabolite
|
Others
|
|
Hydrocinnamic acid-d9 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activitie[2]s.
|
-
- HY-Y1088S3
-
|
3-Phenylpropionic acid-d<sub>5sub>; 3-Phenylpropanoic acid-d<sub>5sub>; 3-Phenyl-n-propionic acid-d<sub>5sub>
|
Endogenous Metabolite
|
Others
|
|
Hydrocinnamic acid-d5 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities[2].
|
-
- HY-Y0086S
-
|
Nicotinealdehyde-d<sub>4sub>; Nicotinic aldehyde-d<sub>4sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Pyridinecarboxaldehyde-d4 is the deuterium labeled 3-Pyridinecarboxaldehyde[1].
|
-
- HY-100808S
-
|
(R)-Serine-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
iGluR
|
Neurological Disease
|
|
D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .
|
-
- HY-158995S1
-
|
3α-Glycyrrhetic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Epiglycyrrhetinic acid-d3 (3α-Glycyrrhetic acid-d3) is the deuterium-labeled 3-Epiglycyrrhetinic acid. 3-Epiglycyrrhetinic acid is a derivative of glycyrrhetic acid. Glycyrrhetic acid and its derivative are considered to have anti-inflammatory, anti-ulcer, and antiviral activities .
|
-
- HY-W004113S
-
-
- HY-W185208S
-
|
Methyldesphenylchloridazon-d<sub>3sub>;
5-Amino-4-chloro-2-methyl-d<sub>3sub>-3(2H)-pyridazinone
|
Isotope-Labeled Compounds
|
Others
|
|
Chloridazon metabolite B1-d3 (Methyldesphenylchloridazon-d3) is deuterium labeled 5-Amino-4-chloro-2-methyl-2,3-dihydropyridazin-3-one .
|
-
- HY-B0113S2
-
|
Omeprazole sulfone (methoxy-d<sub>3sub>); Omeprazole sulphone (methoxy-d<sub>3sub>)
|
Isotope-Labeled Compounds
Drug Metabolite
|
Infection
Cancer
|
|
Omeprazole metabolite Omeprazole sulfone (methoxy-d3) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
|
-
- HY-66008S
-
|
N-Acetyl-5-aminosalicylic acid-d<sub>3sub>; N-Acetyl-ASA-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N-Acetyl mesalazine-d3 is the deuterium labeled N-Acetyl mesalazine[1].
|
-
- HY-W286743S1
-
-
- HY-141580S1
-
|
N-octadecaoyl-D-eytho-Dihydosphigosie-d<sub>3sub>; Ce(d18:0/18:0)-d<sub>3sub>; Ceamide-d<sub>3sub> (d18:0/18:0-d3)
|
Isotope-Labeled Compounds
Others
|
Metabolic Disease
|
|
C18 Dihydroceramide-d3-1 (N-octadecaoyl-D-eytho-Dihydosphigosie-d3) is deuterium labeled C18 Dihydroceramide. C18 Dihydroceramide is an ester product .
|
-
- HY-139429S
-
|
(−)-11-Hydoxy-Δ8-Tetahydocaabiol-d<sub>3sub>; (−)-tas-Δ8-THC-d<sub>3sub>; 7-hydoxy-Δ6-THC-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
(?)-11-Hydroxy-Δ8-THC-d3 ((?)-11-Hydoxy-Δ8-Tetahydocaabiol-d3) is deuterium labeled (?)-11-hydroxy-Δ8-THC .
|
-
- HY-W739949
-
-
- HY-N10634S
-
|
N-ω-CD<sub>3sub>-Hexadecaoyl-glucopsychosie; GluCe(d18:1/16:0-d<sub>3sub>); Glucosylceamide-d<sub>3sub> (d18:1/16:0-d3)
|
Isotope-Labeled Compounds
Others
|
Inflammation/Immunology
|
|
D-Glucosyl-β-N-palmitoylsphingosine-d3 (N-ω-Cd3-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine. D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .
|
-
- HY-A0118S
-
|
NKTR-118-13C<sub>,d<sub>3sub>; AZ-13337019-13C<sub>,d<sub>3sub>
|
Isotope-Labeled Compounds
|
Neurological Disease
Cancer
|
|
Naloxegol- 13C,d3 (NKTR-118- 13C,d3) is 13C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .
|
-
- HY-14855S
-
|
TR 700-13C,d<sub>3sub>; Torezolid-13C,d<sub>3sub>; DA-7157-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Tedizolid- 13C,d3 is the 13C- and deuterium labeled Tedizolid. Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome.
|
-
- HY-B0457S2
-
|
Chlorimipramine-13C,d<sub>3sub> hydrochloride; G-34586-13C,d<sub>3sub> hydrochloride; NSC-169865-13C,d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Serotonin Transporter
|
Neurological Disease
|
|
Clomipramine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
|
-
- HY-B1192S
-
|
β-Estradiol 3-benzoate-d<sub>3sub>; 17β-Estradiol 3-benzoate-d<sub>3sub>
|
Estrogen Receptor/ERR
|
Neurological Disease
|
|
Estradiol benzoate-d3 is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].
|
-
- HY-113468AS1
-
|
3-Methoxy-L-tyrosine-d<sub>3sub> hydrate; 3-O-Methyl-L-DOPA-d<sub>3sub> hydrate
|
Isotope-Labeled Compounds
Drug Metabolite
Interleukin Related
|
Neurological Disease
Inflammation/Immunology
|
|
3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease .
|
-
- HY-Y1644S
-
|
3-Methylcrotonic acid-d<sub>6sub>; 3-Methylbut-2-enoic acid-d<sub>6sub>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3,3-Dimethylacrylic acid-d6 is the deuterium labeled 3,3-Dimethylacrylic acid [1]. 3,3-Dimethylacrylic acid-d6 is an endogenous metabolite .
|
-
- HY-N0304S
-
|
Levodopa-d<sub>6sub>; 3,4-Dihydroxyphenylalanine-d<sub>6sub>
|
Dopamine Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
L-DOPA-d6 is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease[1][2][3].
|
-
- HY-W744643
-
|
3-n-Butylphthalide-d<sub>9sub>; 3-Butylphthalide-d<sub>9sub>
|
Isotope-Labeled Compounds
Others
|
Neurological Disease
|
|
Butylphthalide-d9 (3-n-Butylphthalide-d9) is deuterium labeled Butylphthalide. Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models .
|
-
- HY-B0652S1
-
-
- HY-N0650S3
-
|
(-)-Serine-13C<sub>3sub>,15N,d<sub>3sub>; (S)-Serine-13C<sub>3sub>,15N,d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
L-Serine- 13C3, 15N,d3 is the deuterium, 13C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-13631AS1
-
-
- HY-16508S1
-
|
CDB-2914-d<sub>3sub>
|
Isotope-Labeled Compounds
Progesterone Receptor
Autophagy
|
Endocrinology
Cancer
|
|
Ulipristal acetate-d3 (CDB-2914-d3) is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma .
|
-
- HY-W011727S
-
|
Pyridoxal 5'-phosphate-d<sub>3sub>
|
Endogenous Metabolite
Amyloid-β
ERK
|
Neurological Disease
Metabolic Disease
Cancer
|
|
Pyridoxal Phosphate-d3 is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .
|
-
- HY-W004702S
-
-
- HY-N0138S1
-
-
- HY-70050CS
-
-
- HY-W020678S1
-
-
- HY-B0321S
-
|
Ro 1-7683-d<sub>3sub>
|
mAChR
|
Neurological Disease
|
|
Tropicamide-d3 is the deuterium labeled Tropicamide[1]. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops[2][3].
|
-
- HY-19489S1
-
-
- HY-121883S1
-
|
Tetracosanoic acid-d<sub>3sub>
|
Endogenous Metabolite
|
Neurological Disease
|
|
Lignoceric acid-d3 is the deuterium labeled Lignoceric acid[1]. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[2][3].
|
-
- HY-14946S
-
|
3,4-Diaminopyridine-d<sub>3sub>
|
Isotope-Labeled Compounds
Potassium Channel
|
Neurological Disease
|
|
Amifampridine-d3 (3,4-Diaminopyridine-d3) is deuterium labeled Amifampridine. Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research .
|
-
- HY-B0175S
-
|
BAY-i 9142-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Infection
|
|
Toltrazuril-d3 is deuterated labeled Toltrazuril. Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.
|
-
- HY-B0241S
-
|
Sch 1000-d<sub>3sub>
|
mAChR
|
Neurological Disease
Inflammation/Immunology
|
|
Ipratropium-d3 (bromide) is the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].
|
-
- HY-A0009S
-
|
Galantamine-d<sub>3sub> hydrobromide
|
Isotope-Labeled Compounds
Cholinesterase (ChE)
nAChR
|
Neurological Disease
|
|
Galanthamine-d3 (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD)[1][2][3].
|
-
- HY-113037S1
-
-
- HY-W010892S
-
-
- HY-102015S
-
-
- HY-B0157S1
-
-
- HY-N7057S1
-
|
Pelargonic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Nonanoic acid-d3 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].
|
-
- HY-B0332S
-
-
- HY-15394S1
-
|
N-0437-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Adrenergic Receptor
Dopamine Receptor
5-HT Receptor
|
Endocrinology
|
|
(Rac)-Rotigotine-d3 hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
|
-
- HY-136450S
-
|
TCBZ-SO-d<sub>3sub>
|
Isotope-Labeled Compounds
Parasite
BCRP
|
Infection
|
|
Triclabendazole sulfoxide-d3 is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
|
-
- HY-B0019S
-
|
(Rac)-SENS-401-d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
Azasetron-d3 (hydrochloride) is the deuterium labeled Azasetron hydrochloride[1].
|
-
- HY-78131BS
-
|
(R)-Ibuprofen-d<sub>3sub>
|
NF-κB
|
Inflammation/Immunology
Cancer
|
|
(R)-(-)-Ibuprofen-d3 is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
|
-
- HY-50667S1
-
|
BMS-562247-01-d<sub>3sub>
|
Isotope-Labeled Compounds
Factor Xa
|
Others
|
|
Apixaban-d3 (BMS-562247-01-d3) is the deuterium labeled Apixaban (HY-50667) . Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .
|
-
- HY-122426S1
-
-
- HY-113346S
-
|
Tetrahydro-11-deoxycorticosterone-d<sub>3sub>
|
Isotope-Labeled Compounds
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
Tetrahydrodeoxycorticosterone-d3 is the deuterium labeled Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2][3].
|
-
- HY-78131AS
-
|
(S)-Ibuprofen d<sub>3sub>
|
COX
|
Inflammation/Immunology
|
|
(S)-(+)-Ibuprofen-d3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].
|
-
- HY-10331S
-
|
BAY 73-4506-d<sub>3sub>
|
VEGFR
Autophagy
PDGFR
Raf
RET
|
Cancer
|
|
Regorafenib-d3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor[1].
|
-
- HY-B0106S1
-
|
UCB L059-d<sub>3sub>
|
DNA Methyltransferase
|
Neurological Disease
Cancer
|
|
Levetiracetam-d3 is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].
|
-
- HY-135035S
-
|
(-)-Decanoylcarnitine-d<sub>3sub>
|
Isotope-Labeled Compounds
Others
|
Metabolic Disease
|
|
Decanoyl-L-carnitine-d3 ((-)-Decanoylcarnitine-d3) is deuterium labeled Decanoyl-L-carnitine. Decanoyl-L-carnitine has stimulatory effect on the formation of desaturated fatty acid metabolites from both [1- 14C]-22:4 (n-6) and [1- 14C]-22:5 (n-3) .
|
-
- HY-B1053S
-
-
- HY-113335S
-
-
- HY-W003972S
-
|
Syringol-d<sub>3sub>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
2,6-Dimethoxyphenol-d3 (Syringol-d3) is the deuterium labeled 2,6-Dimethoxyphenol (HY-W003972) . 2,6-Dimethoxyphenol is a phenolic compound that scavenges free radicals and exhibits antioxidant activity. 2,6-Dimethoxyphenol is the substrate for determining laccase activity .
|
-
- HY-N0384S
-
|
Vanilacetic acid-d<sub>3sub>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Homovanillic acid-d3 is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
|
-
- HY-113466S
-
|
4-HNE-d<sub>3sub>
|
Isotope-Labeled Compounds
Aldehyde Dehydrogenase (ALDH)
Endogenous Metabolite
|
Cardiovascular Disease
Neurological Disease
Cancer
|
|
4-Hydroxynonenal-d3 is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].
|
-
- HY-B0204S1
-
-
- HY-41417S1
-
|
Caprylic acid-d<sub>3sub>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Octanoic acid-d3 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
|
-
- HY-10250S1
-
|
TCN-P-d<sub>3sub>
|
Isotope-Labeled Compounds
ATP Synthase
|
Metabolic Disease
|
|
Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .
|
-
- HY-13693S
-
-
- HY-W017077S
-
|
4-Phenyltoluene-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
4-Methylbiphenyl-d3 (4-Phenyltoluene-d3) is the deuterium labeled 4-Methylbiphenyl (HY-W017077). 4-Methylbiphenyl is an endogenous metabolite .
|
-
- HY-B0740S
-
|
MK130-d<sub>3sub> (hydrochloride)
|
5-HT Receptor
|
Neurological Disease
|
|
Cyclobenzaprine-d3 (hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.
|
-
- HY-B1832S
-
|
Prednisone 21-acetate-d<sub>3sub>
|
Glucocorticoid Receptor
|
Inflammation/Immunology
Endocrinology
|
|
Prednisone acetate-d3 is the deuterium labeled Prednisone acetate. Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties[1].
|
-
- HY-B0311S1
-
|
(S)-(-)-Carbidopa-d<sub>3sub>
|
Aryl Hydrocarbon Receptor
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .
|
-
- HY-N8253S
-
|
Spiraeoside-d<sub>3sub>
|
Isotope-Labeled Compounds
Reactive Oxygen Species
|
Inflammation/Immunology
Cancer
|
|
Quercetin 4'-Glucoside-d3 (Spiraeoside-d3) is deuterium labeled Spiraeoside. Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .
|
-
- HY-W042416S2
-
|
DMAc-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N,N-Dimethylacetamide-d3 is the deuterium labeled N,N-Dimethylacetamide[1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent[2].
|
-
- HY-N6703S
-
|
(+)-ar-Turmerone-d<sub>3sub>
|
Isotope-Labeled Compounds
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
ar-Turmerone-d3 is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .
|
-
- HY-W004260S2
-
|
Icosanoic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Arachidic acid-d3) is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
|
-
- HY-12530S1
-
|
GS-5816-d3<sub>3sub>
|
Isotope-Labeled Compounds
SARS-CoV
HCV
|
Infection
Inflammation/Immunology
Cancer
|
|
Velpatasvir-d3 (GS-5816-d3) is deuterium labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
|
-
- HY-W654210
-
|
Glycopyrronium-d<sub>3sub> bromide
|
Isotope-Labeled Compounds
mAChR
|
Cancer
|
|
Glycopyrrolate-d3 (bromide) is deuterium labeled Glycopyrrolate. Glycopyrrolate (Glycopyrronium bromide), a quaternary ammonium derivative, is a muscarinic receptor antagonist. Glycopyrrolate has bronchoprotective effect and produces a beneficial effect on blood pressure. Glycopyrrolate can be used for the research of bronchial diseases .
|
-
- HY-B0192AS
-
-
- HY-75054S1
-
|
CB7630-d<sub>3sub>
|
Isotope-Labeled Compounds
Cytochrome P450
|
Cancer
|
|
Abiraterone acetate-d3 (CB7630-d3) is deuterium labeled Abiraterone acetate. Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. Abiraterone acetate is a proagent form of Abiraterone (CB7598) .
|
-
- HY-B0440S
-
-
- HY-13704S
-
|
NK012-d<sub>3sub>
|
Topoisomerase
ADC Cytotoxin
Autophagy
|
Cancer
|
|
SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].
|
-
- HY-N0367S
-
|
(E)-Anethole-d<sub>3sub>
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Endocrinology
|
|
Trans-Anethole-d3 is deuterated labeled α-Terpineol (HY-N5142). α-Terpineol is isolated from Eucalyptus globulus Labill, exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria .
α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption .
|
-
- HY-77995S
-
|
o-Anisaldehyde-d<sub>3sub>
|
Fungal
Bacterial
|
Infection
|
|
2-Methoxybenzaldehyde-d3 is the deuterium labeled 2-Methoxybenzaldehyde[1]. 2-Methoxybenzaldehyde (o-Anisaldehyde), isolated from cinnamon essential oil (CEO), exists antibacterial and antifungal activity[2].
|
-
- HY-111372S
-
|
BAY 94-8862-d<sub>3sub>
|
Mineralocorticoid Receptor
|
Others
|
|
Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .
|
-
- HY-B0412S4
-
-
- HY-113527S
-
|
1-Methylnicotinamide-d<sub>3sub> chloride
|
Endogenous Metabolite
|
Metabolic Disease
|
|
TRIA-662-d3 is the deuterium labeled TRIA-662[1]. TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities[2].
|
-
- HY-151931S
-
-
- HY-17402S3
-
-
- HY-B0311AS
-
|
(S)-(-)-Carbidopa-d<sub>3sub> (monohydrate)
|
Aryl Hydrocarbon Receptor
|
Neurological Disease
Cancer
|
|
Carbidopa-d3 (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].
|
-
- HY-W160631S
-
-
- HY-123341S
-
-
- HY-N7046S
-
|
Silibinin B-d<sub>3sub>
|
Isotope-Labeled Compounds
Amyloid-β
|
Neurological Disease
Cancer
|
|
Silybin B-d3 (Silibinin B-d3) is deuterium labeled Silybin B. Silybin B (Silibinin B), a flavonolignan separated from Silybum marianum, has anti-tumor activity. Silybin B is the most potent antifibrillogenic and anti-oligomeric component of silymarin and proposes it as a promising anti Alzheimer’s disease agent candidate .
|
-
- HY-13238S1
-
|
S/GSK1349572-d<sub>3sub>
|
Isotope-Labeled Compounds
HIV Integrase
HIV
|
Infection
|
|
Dolutegravir-d3 is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].
|
-
- HY-B0197AS
-
-
- HY-W012835S1
-
|
4-Methoxytoluene-d<sub>3sub>
|
Virus Protease
|
Others
|
|
4-Methylanisole-d3 is the deuterium labeled 4-Methylanisole[1]. 4-Methylanisole (4-Methoxytoluene) is food flavoring agent and can be naturally found in Ylang Ylang fragrance oil[2].
|
-
- HY-B0188AS
-
|
Org GB 94-d<sub>3sub>
|
Histamine Receptor
|
Neurological Disease
Endocrinology
|
|
Mianserin-d3 (hydrochloride) is the deuterium labeled Mianserin hydrochloride. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
|
-
- HY-66011AS2
-
|
BAY 12-8039-d<sub>3sub>
|
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Moxifloxacin-d3 (hydrochloride) is the deuterium labeled Moxifloxacin hydrochloride. Moxifloxacin hydrochloride is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia[1][2][3].
|
-
- HY-B1453S
-
-
- HY-W013049S3
-
|
Behenic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
DNA/RNA Synthesis
|
Metabolic Disease
Cancer
|
|
Docosanoic acid-d3 (Behenic acid-d3) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
|
-
- HY-15025S2
-
|
UK-92480-d<sub>3sub>N<sub>-1
|
Phosphodiesterase (PDE)
|
Cancer
|
|
Sildenafil-d3-1 (UK-92480-d3-1) is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
|
-
- HY-Y0139S
-
-
- HY-14602S
-
|
Homotaurine-d<sub>6sub>; 3-Amino-1-propanesulfonic acid-d<sub>6sub>
|
Amyloid-β
|
Cancer
|
|
Tramiprosate-d6 is the deuterium labeled Tramiprosate. Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].
|
-
- HY-N0210S8
-
-
- HY-B0673S1
-
-
- HY-13318S1
-
|
GS 4071-13C,d<sub>3sub>; Ro 64-0802-13C,d<sub>3sub>; Oseltamivir carboxylate-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Drug Metabolite
Influenza Virus
|
Infection
|
|
Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC50=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections .
|
-
- HY-W707416S
-
|
N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)-DL-alanine-d<sub>3sub>; N-(2-Methoxyacetyl)-N-(2,6-xylyl)-DL-alanine-d<sub>3sub>; CGA 62826-d<sub>3sub>; rac-Metalaxyl carboxylic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N-(2,6-Dimethylphenyl)-N-(2-(methoxy-d3)acetyl)alanine (N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)-DL-alanine-d3) is deuterium labeled N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)alanine .
|
-
- HY-66008S1
-
|
N-Acetyl-5-aminosalicylic acid-d<sub>3sub>-1; N-Acetyl-ASA-d<sub>3sub>-1
|
Isotope-Labeled Compounds
|
Others
|
|
N-Acetyl mesalazine-d3-1 is deuterium labeled 5-acetamido-2-hydroxybenzoic acid.
|
-
- HY-100427S
-
|
CL29926-13C,d<sub>3sub>; (±)-Imazamox-13C,d<sub>3sub>
|
Acetolactate Synthase (ALS)
Isotope-Labeled Compounds
|
Others
|
|
Imazamox- 13C,d3 is the 13C- and deuterium labeled Imazamox. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death[1][2].
|
-
- HY-40354S2
-
|
Tasocitinib-13C,d<sub>3sub>; CP-690550-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
Cancer
|
|
Tofacitinib- 13C,d3 (Tasocitinib- 13C,d3) is 13C labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
|
-
- HY-10219S1
-
|
Sirolimus-13C,d<sub>3sub>; AY-22989-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
mTOR
FKBP
Autophagy
|
Cancer
|
|
Rapamycin- 13C,d3 (Sirolimus- 13C,d3; AY-22989- 13C,d3) is the 13C and deuterium labeled Rapamycin (HY-10219) .Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
|
-
- HY-90001S1
-
|
ABT 538-13C,d<sub>3sub>; RTV-13C,d<sub>3sub>
|
HIV Protease
HIV
SARS-CoV
Apoptosis
|
Infection
|
|
Ritonavir- 13C,d3 is the 13C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
|
-
- HY-165662S
-
|
Pyaopofe-13C-d<sub>3sub>; Y 8004-13C-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Pranoprofen- 13C-d3 (Pyaopofe- 13C-d3) is 13C and deuterium labeled Pranoprofen .
|
-
- HY-121309S1
-
|
Adriamycin aglycone-13C,d<sub>3sub>; Adriamycinone-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
Doxorubicinone- 13C,d3 (Adriamycin aglycone- 13C,d3) is 13C labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
|
-
- HY-17034AS
-
|
(+)-Medetomidine-13C,d<sub>3sub> hydrochloride; (S)-Medetomidine-13C,d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Neurological Disease
Endocrinology
Cancer
|
|
Dexmedetomidine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].
|
-
- HY-15772S1
-
|
AZD-9291-13C,d<sub>3sub>; Mereletinib-13C,d<sub>3sub>
|
EGFR
|
Cancer
|
|
Osimertinib- 13C,d3 is the deuterium and 13C labeled Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively.
|
-
- HY-W014423S7
-
-
- HY-138573S
-
-
- HY-A0023AS1
-
-
- HY-14956S1
-
|
TG-873870-d<sub>3sub>-1
|
Bacterial
|
Inflammation/Immunology
|
|
Nemonoxacin-d3-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].
|
-
- HY-170013S
-
|
Metoitazepye-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N-Pyrrolidino Metonitazene-d3 (citrate) (Metoitazepye-d3) is deuterium labeled N-Pyrrolidino Metonitazene (citrate) .
|
-
- HY-90009BS
-
-
- HY-W012982S
-
|
AOZ-d<sub>4sub>
|
Drug Metabolite
|
Others
|
|
3-Amino-2-oxazolidinone-d4 is a deuterium labeled 3-Amino-2-oxazolidinone. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as an indicator of furazolidone residues[1][2].
|
-
- HY-113136S
-
|
N1-Methylguanosine-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
1-Methylguanosine-d3 is deuterium labeled 1-Methylguanosine (HY-113136). 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker .
|
-
- HY-153939S
-
|
RG7388-d<sub>3sub>-1
|
Isotope-Labeled Compounds
|
Cancer
|
|
Idasanutlin-d3-1 (RG7388-d3-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of MDM2/p53. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia .
|
-
- HY-34439S1
-
|
NSC 49139-d<sub>3sub>
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
2,5-Dimethylpyrazine-d3 is deuterated labeled γ-Terpinene (HY-W020183). γ-Terpinene, a monoterpene, is an orally active antioxidant compound which can scavenge radicals directly. γ-Terpinene has potent antinociception activity .
|
-
- HY-17490S
-
|
N-Acetyl-L-hydroxyproline-d<sub>3sub>
|
Isotope-Labeled Compounds
Amino Acid Derivatives
|
Inflammation/Immunology
|
|
Oxaceprol-d3 (N-Acetyl-L-hydroxyproline-d3) is deuterium labeled Oxaceprol. Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis .
|
-
- HY-119695AS2
-
-
- HY-17504AS
-
-
- HY-141582S
-
|
N-Stearoyl phytosphingosine-d<sub>3sub>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Ceramide 3-d3 (N-Stearoyl phytosphingosine-d3) is deuterium labeled Ceramide 3. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation .
|
-
- HY-10201S4
-
|
Donafenib tosylate; Bay 43-9006-d<sub>3sub> tosylate
|
Isotope-Labeled Compounds
Raf
VEGFR
FLT3
Autophagy
Apoptosis
Ferroptosis
|
Cancer
|
|
Sorafenib-d3 (Donafenib) tosylate is the 13C- and deuterium labeled Sorafenib. Sorafenib-d3tosylate is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib-d3tosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib-d3tosylate induces autophagy and apoptosis. Sorafenib-d3tosylate has anti-tumor activity. Sorafenib is a ferroptosis activator .
|
-
- HY-17360S
-
|
BA679 BR-d<sub>3sub>
|
Isotope-Labeled Compounds
mAChR
|
Neurological Disease
|
|
Tiotropium-d3 (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
|
-
- HY-113139S
-
-
- HY-W754135
-
-
- HY-I0637S
-
|
3-Hydroxy-4-methoxybenzaldehyde-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Isovanillin-d3 is the deuterium labeled Isovanillin[1]. Isovanillin is an aldehyde oxidase inhibitor[2]. Antispasmodic activities[3]. Antidiarrheal activities[4].
|
-
- HY-113371S
-
|
Methylcitric acid-d<sub>3sub>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
|
-
- HY-14781S3
-
-
- HY-B0113S1
-
|
H 16868-d<sub>3sub>-1
|
Proton Pump
Autophagy
Bacterial
Phospholipase
|
Infection
Metabolic Disease
Cancer
|
|
Omeprazole-d3-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].
|
-
- HY-B0561S2
-
-
- HY-10201S
-
|
Donafenib; Bay 43-9006-d<sub>3sub>
|
Raf
VEGFR
FLT3
Ferroptosis
Autophagy
Apoptosis
|
Cancer
|
|
Sorafenib-d3 (Donafenib), a deuterated compound of Sorafenib, is the first deuterium-generation tumor suppressor small molecule. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively .
|
-
- HY-117580S
-
|
OH-PRED-d<sub>3sub>
|
Drug Metabolite
|
Inflammation/Immunology
|
|
16α-Hydroxyprednisolone-d3 is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes[1][2].
|
-
- HY-W097453S1
-
-
- HY-W100443S
-
|
Trimethylptolylsilane-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Trimethyl(p-tolyl)silane-d3 (Trimethylptolylsilane-d3) is the deuterium labeled Trimethyl(p-tolyl)silane (HY-W440454) .
|
-
- HY-14281S2
-
-
- HY-B0740S3
-
|
MK130-d<sub>3sub>-1 hydrochloride
|
Isotope-Labeled Compounds
5-HT Receptor
Parasite
|
Infection
Neurological Disease
|
|
Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases
|
-
- HY-125446S
-
-
- HY-108263S
-
|
CGP52421-d<sub>5sub>
|
Isotope-Labeled Compounds
FLT3
|
Cancer
|
|
3-Hydroxy Midostaurin-d5 is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].
|
-
- HY-B1786S
-
-
- HY-B0197S
-
|
GR-85548A-d<sub>3sub>-1
|
5-HT Receptor
|
Neurological Disease
|
|
Naratriptan-d3 is the deuterium labeled Naratriptan[1]. Naratriptan is a selective 5-HT1 receptor subtype agonist[2].
|
-
- HY-W016481S
-
-
- HY-W015778S
-
-
- HY-B1433S
-
-
- HY-137989S
-
|
Voriconazole oxynitride-d<sub>3sub>
|
Isotope-Labeled Compounds
Fungal
|
Infection
|
|
Voriconazole N-oxide-d3 (Voriconazole oxynitride-d3) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB) .
|
-
- HY-10284S3
-
-
- HY-W102356S
-
-
- HY-12142S
-
|
rac-GR 205171-d<sub>3sub>
|
Isotope-Labeled Compounds
Neurokinin Receptor
|
Others
|
|
rac-Vofopitant-d3 (rac-GR 205171-d3) is the deuterium labeled Vofopitant (HY-12142) . Vofopitant is potent tachykinin NK1 receptor antagonist, with pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively .
|
-
- HY-B1565S
-
-
- HY-B0075S1
-
-
- HY-W007355S1
-
-
- HY-N0230S2
-
-
- HY-32349S
-
-
- HY-32351S
-
|
25-hydroxy Vitamin D3-d<sub>3sub>
|
Isotope-Labeled Compounds
VD/VDR
Endogenous Metabolite
|
Metabolic Disease
|
|
Calcifediol-d3 is a deuterium labeled Calcifediol. Calcifediol, is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
|
-
- HY-10002S1
-
|
1,25-Dihydroxyvitamin D3-d<sub>3sub>
|
VD/VDR
Endogenous Metabolite
|
Cancer
|
|
Calcitriol-d3 is the deuterium labeled Calcitriol[1]. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist[2][3][4][5].
|
-
- HY-B0495S1
-
|
LTG-13C,d<sub>3sub>; BW430C-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Sodium Channel
Autophagy
|
Neurological Disease
|
|
Lamotrigine- 13C,d3 is the 13C- and deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
|
-
- HY-13683S1
-
|
RU486-13C,d<sub>3sub>; RU 38486-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Progesterone Receptor
Glucocorticoid Receptor
NO Synthase
Autophagy
|
Endocrinology
Cancer
|
|
Mifepristone- 13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-15321S1
-
|
MK-0663-13C,d<sub>3sub>; L-791456-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
|
Etoricoxib- 13C,d3 is the 13C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
|
-
- HY-10241S
-
|
TMC435-13C,d<sub>3sub>; TMC435350-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
HCV
HCV Protease
SARS-CoV
DNA/RNA Synthesis
|
Infection
|
|
Simeprevir- 13C,d3 is the 13C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].
|
-
- HY-N0650S9
-
|
(-)-Serine-15N,d<sub>3sub>; (S)-Serine-15N,d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
L-Serine- 15N,d3 is the deuterium and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-18569S2
-
|
Indole-3-acetic acid-2,2-d<sub>2sub>; 3-IAA-2,2-d<sub>2sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Indoleacetic acid-2,2-d2 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
|
-
- HY-B0002BS2
-
-
- HY-10999S2
-
|
GSK1120212-13C,d<sub>3sub>; JTP-74057-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
MEK
Autophagy
Apoptosis
|
Cancer
|
|
Trametinib- 13C,d3 is the 13C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].
|
-
- HY-B0389S18
-
|
Glucose-13C<sub>3sub>-1; D-(+)-Glucose-13C<sub>3sub>-1; Dextrose-13C<sub>3sub>-1
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-B0389S9
-
|
Glucose-13C<sub>3sub>-2; D-(+)-Glucose-13C<sub>3sub>-2; Dextrose-13C<sub>3sub>-2
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Glucose- 13C3-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
- HY-N0098S
-
|
p-Vanillin-13C,d<sub>3sub>; m-Methoxy-p-hydroxybenzaldehyde-13C,d<sub>3sub>; p-Hydroxy-m-methoxybenzaldehyde-13C,d<sub>3sub>
|
Endogenous Metabolite
|
Others
|
|
Vanillin- 13C,d3 is the 13C and deuterium labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
|
-
- HY-15236S
-
|
RO-2433-13C,d<sub>3sub>; GS-331007-13C,d<sub>3sub>; Sofosbuvir metabolite GS-331007-13C,d<sub>3sub>
|
HCV
|
Infection
|
|
PSI-6206- 13C,d3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
|
-
- HY-123489S
-
|
THDOC-d<sub>3sub>
|
GABA Receptor
|
Neurological Disease
|
|
3α,21-Dihydroxy-5α-pregnan-20-one-d3 is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
|
-
- HY-Y1313S
-
|
m-Carboxynitrobenzene-d<sub>4sub>; m-Nitrobenzenecarboxylic acid-d<sub>4sub>; m-Nitrobenzoic acid-d<sub>4sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Nitrobenzoic acid-d4 is the deuterium labeled 3-Nitrobenzoic acid[1].
|
-
- HY-19733S
-
|
ITI-007-CH<sub>C,d<sub>3sub> tosylate
|
Isotope-Labeled Compounds
Dopamine Receptor
5-HT Receptor
|
Neurological Disease
Cancer
|
|
Lumateperone- 13C,d3 (ITI-007- 13C,d3) tosylate is 13C and deuterium labeled Lumateperone (tosylate). Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia .
|
-
- HY-14153AS
-
|
SDZ-HTF-919-13C,d<sub>3sub>; HTF-919-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
5-HT Receptor
|
Neurological Disease
Metabolic Disease
|
|
Tegaserod- 13C,d3 (maleate) is the 13C- and deuterium labeled Tegaserod (maleate). Tegaserod maleate is a selective 5-HT4 receptor partial agonist and a 5-HT2B receptor antagonist. Tegaserod maleate exhibits a promotile effect throughout the gastrointestinal (GI) tract[1][2][5].
|
-
- HY-B0957S
-
|
Erythromycin ethyl succinate-13C,d<sub>3sub>; EES-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Bacterial
HIV
Autophagy
Antibiotic
|
Infection
|
|
Erythromycin ethylsuccinate- 13C,d3 is the 13C- and deuterium labeled Erythromycin Ethylsuccinate. Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.
|
-
- HY-B0471S1
-
|
(R)-(-)-Phenylephrine-2,4,6-d<sub>3sub> (hydrochloride); L-Phenylephrine-2,4,6-d<sub>3sub> (hydrochloride)
|
Adrenergic Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Phenylephrine-2,4,6-d3 (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
|
-
- HY-15463S3
-
|
STI571-13C,d<sub>3sub>; CGP-57148B-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Autophagy
SARS-CoV
Bcr-Abl
PDGFR
c-Kit
|
Cancer
|
|
Imatinib- 13C,d3 (STI571- 13C,d3) is 13C labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and MERS-CoV .
|
-
- HY-13629S1
-
-
- HY-10163S3
-
|
BIBR 953-13C,d<sub>3sub>; BIBR 953ZW-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Thrombin
|
Cardiovascular Disease
|
|
Dabigatran- 13C,d3 is the 13C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].
|
-
- HY-15005S
-
|
PSI-7977-13C,d<sub>3sub>; GS-7977-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
HCV
|
Infection
|
|
Sofosbuvir- 13C,d3 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-G0007S1
-
|
Omeprazole sulfone-13C,d<sub>3sub>; Omeprazole sulphone-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Omeprazole metabolite Omeprazole sulfone- 13C,d3 is the deuterium and 13C labeled Omeprazole metabolite Omeprazole sulfone[1].
|
-
- HY-125818S5
-
|
Cytidine triphosphate-15N<sub>3sub>,d<sub>14sub> dilithium; 5'-CTP-15N<sub>3sub>,d<sub>14sub> dilithium
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Infection
Cancer
|
|
Cytidine-5'-triphosphate- 15N3,d14 (Cytidine triphosphate- 15N3,d14 dilithium; 5'-CTP- 15N3,d14) dilithium is deuterium and 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
|
-
- HY-101400S1
-
|
dCTP-15N<sub>3sub>,d<sub>14sub> dilithium; 2′-Deoxycytidine-5′-triphosphate-15N<sub>3sub>,d<sub>14sub> dilithium
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Endogenous Metabolite
|
Metabolic Disease
|
|
Deoxycytidine triphosphate- 15N3,d14 (dCTP- 15N3,d14 dilithium; 2′-Deoxycytidine-5′-triphosphate- 15N3,d14) dilithium is deuterium and 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
|
-
- HY-113018S
-
|
Ibuprofen glucuronide-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Ibuprofen acyl-β-D-glucuronide-d3 is the deuterium labeled Ibuprofen acyl-β-D-glucuronide[1].
|
-
- HY-W357141S
-
-
- HY-W015084AS
-
-
- HY-17453S
-
|
GR 33343X-d<sub>3sub> xinafoate
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Inflammation/Immunology
Endocrinology
|
|
Salmeterol-d3 (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].
|
-
- HY-165703S
-
|
Prothioconazole-M01-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Prothioconazole-S-methyl-d3 (Prothioconazole-M01-d3) is deuterium labeled Prothioconazole-S-methyl .
|
-
- HY-Y0678S
-
|
Trimethyl phloroglucinol-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
1,3,5-Trimethoxybenzene-d3 (Trimethyl phloroglucinol-d3) is the deuterium labeled 1,3,5-Trimethoxybenzene (HY-Y0678). 1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor .
|
-
- HY-101411S
-
-
- HY-W012499S
-
|
N-Acetylmethionine-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
N-Acetyl-L-methionine-d3 is the deuterium labeled N-Acetyl-L-methionine. N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development[1].
|
-
- HY-108229S
-
|
6β-Hydroxynaltrexone-d<sub>3sub>
|
Isotope-Labeled Compounds
Opioid Receptor
Drug Metabolite
|
Neurological Disease
|
|
6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit .
|
-
- HY-100642S
-
|
Ro 40-7591 d<sub>7sub>
|
COMT
|
Neurological Disease
|
|
3-O-Methyltolcapone-d7 is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].
|
-
- HY-12769S2
-
|
Mebeverine metabolite Mebeverine acid-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Mebeverine acid-d3 (Mebeverine metabolite Mebeverine acid-d3) is deuterium labeled Mebeverine acid. Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine. Mebeverine is an antispasmodic agent. Mebeverine acid is a valuable marker of oral exposure to Mebeverine .
|
-
- HY-W015912S
-
|
2-Furyl methyl ketone-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Acetylfuran-d3 is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na +/K +-ATPase whereas in microsomes, both Na +/K +-ATPase and Mg 2+-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .
|
-
- HY-B0712S
-
|
Ro 13-9904-d<sub>3sub> disodium
|
Bacterial
Antibiotic
|
Infection
|
|
Ceftriaxone-d3 (disodium) is the deuterium labeled Ceftriaxone. Ceftriaxone is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics[1][2].
|
-
- HY-N0384S4
-
|
Vanilacetic acid-d<sub>3sub>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .
|
-
- HY-N0229S12
-
|
L-2-Aminopropionic acid-d<sub>3sub>
|
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
L-Alanine-d3 is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-W654228
-
-
- HY-W027544S
-
|
7-Methoxycoumarin-4-acetic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
Fluorescent Dye
|
Others
|
|
MCA-d3 (7-Methoxycoumarin-4-acetic acid3) is the deuterium labeled MCA (HY-W027544) . MCA is a Coumarin (HY-N0709) derivative. MCA quantitates platelet-activating factor (PAF) by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
|
-
- HY-Y0085S
-
-
- HY-165690
-
|
Dimethylsulfamic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N,N-Dimethylaminosulfonic acid-d3 (Dimethylsulfamic acid-d3) is deuterium labeled N,N-Dimethylaminosulfonic acid .
|
-
- HY-12770S1
-
-
- HY-W017374S1
-
-
- HY-B1244S
-
|
1,2-Dimethyl-5-nitroimidazole-d<sub>3sub>
|
Parasite
Antibiotic
|
Infection
|
|
Dimetridazole-d3 is a deuterium labeled Dimetridazole. Dmetridazole, a nitroimidazole-based antibiotic, combats protozoan infections[1].
|
-
- HY-N2362S2
-
|
DL-2-Aminopropionic acid-d<sub>3sub>
|
Endogenous Metabolite
|
Metabolic Disease
|
|
DL-Alanine-d3 is the deuterium labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].
|
-
- HY-W017140S
-
|
SBMP-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Sec-butyl-3-methoxypyrazine-d3 is deuterated labeled cis-?Jasmone (HY-N7058). Cis-Jasmone is a plant-derived natural product. Cis-Jasmone is constitutively released by many flowers and sometimes by leaves as an attractant for pollinators or as a chemical cue for host location by insect flower herbivores. Cis-Jasmone treatment of crop plants not only induces direct defense against herbivores, but also induces indirect defense by releasing VOCs that attract natural enemies .
|
-
- HY-W740027
-
-
- HY-76547S2
-
|
4-Methylbenzoic acid-d<sub>3sub>
|
Endogenous Metabolite
|
Others
|
|
p-Toluic acid-d3 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
|
-
- HY-W041300S
-
|
p-Tolylboronic acid pinacol ester-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
p-Tolylpinacolboronate-d3 (p-Tolylboronic acid pinacol ester-d3) is the deuterium labeled 4,4,5,5-Tetramethyl-2-(p-tolyl)-1,3,2-dioxaborolane (HY-N0350) .
|
-
- HY-W017554S
-
-
- HY-135910S
-
|
OPC-13015-d<sub>11sub>
|
Drug Metabolite
Isotope-Labeled Compounds
|
Cancer
|
|
3,4-Dehydro Cilostazol-d11 is deuterated labeled 3,4-Dehydro Cilostazol (HY-135910). 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study .
|
-
- HY-W016099S
-
|
MQCA-d<sub>4sub>
|
Isotope-Labeled Compounds
|
Cancer
|
|
3-Methyl-2-quinoxalinecarboxylic acid-d4 is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].
|
-
- HY-34487S3
-
|
Resorcinol dimethyl ether-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
1,3-Dimethoxybenzene-d3 (Resorcinol dimethyl ether-d3) is the deuterium labeled 1,3-Dimethoxybenzene (HY-34487). 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds .
|
-
- HY-100642S1
-
|
Ro 40-7591-d<sub>4sub>
|
Isotope-Labeled Compounds
COMT
|
Neurological Disease
|
|
3-O-Methyltolcapone-d4 is the deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].
|
-
- HY-N0060BS
-
|
(E)-Coniferic acid-d<sub>3sub>
|
β-catenin
Bcl-2 Family
Ferroptosis
Endogenous Metabolite
|
Cancer
|
|
(E)-Ferulic acid-d3 is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
|
-
- HY-66011AS3
-
|
BAY 12-8039-d<sub>3sub>-1
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Moxifloxacin-d3-1 hydrochloride (BAY 12-8039-d3-1) is a deuterium labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia .
|
-
- HY-Y0957S
-
-
- HY-B1659S
-
-
- HY-W009162S3
-
|
5'-Cytidylic acid-15N<sub>3sub>,d<sub>12sub> dilithium; 5'-CMP-15N<sub>3sub>,d<sub>12sub> dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Cytidine 5′-monophosphate- 15N3,d12 (5'-Cytidylic acid- 15N3,d12 dilithium; 5'-CMP- 15N3,d12) dilithium is deuterium and 15N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
|
-
- HY-121259S
-
|
Adriamycinol-13C,d<sub>3sub> TFA; DXR-OL-13C,d<sub>3sub> TFA
|
Endogenous Metabolite
|
Others
|
|
Doxorubicinol- 13C,d3 (TFA) is the deuterium and 13C labeled Doxorubicinol TFA[1].
|
-
- HY-10158S1
-
|
SKI-606-13C<sub>,d<sub>3sub>
|
Isotope-Labeled Compounds
Autophagy
Bcr-Abl
Src
|
Cancer
|
|
Bosutinib- 13C,d3 (SKI-606- 13C,d3) is 13C labeled Bosutinib. Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively .
|
-
- HY-17410S2
-
-
- HY-G0020S1
-
|
Nicotine N-glucuronide-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Nicotine N-β-D-glucuronide-d3 (Nicotine N-glucuronide-d3) is a deuterium labeled compound.
|
-
- HY-32350S1
-
|
1α,25-Dihydroxy Vitamin D2-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Ercalcitriol-d3 is the deuterium labeled Ercalcitriol. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-W102278S
-
|
2,4-Di-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)phenol-d<sub>3sub>(UV-327-d<sub>3sub>)
|
Isotope-Labeled Compounds
|
Others
|
|
Tinuvin-327-d3 (2,4-Di-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)phenol-d3 (UV-327-d3)) is deuterium labeled 2,4-Di-tert-butyl-6-(5-chloro-2H-benzo[d][1,2,3]triazol-2-yl)phenol .
|
-
- HY-Y1169S2
-
|
4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate-d<sub>3sub>; Fmoc-L-Asp(OtBu)-OH-d<sub>3sub>
|
Isotope-Labeled Compounds
Amino Acid Derivatives
|
Others
|
|
Fmoc-Asp(OtBu)-OH-d3 (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate-d3) is deuterium labeled Fmoc-Asp(OtBu)-OH. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
|
-
- HY-W042164S
-
|
N-Methyl-p-toluidine-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N,4-Dimethylaniline-d3 (N-Methyl-p-toluidine-d3) is the deuterium labeled N,4-Dimethylaniline.
|
-
- HY-90009BS2
-
-
- HY-114524S
-
-
- HY-W086988S
-
|
5-Methylbenzotriazole-d<sub>3sub>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
5-Methyl-1H-benzotriazole-d6 (5-Methylbenzotriazole-d6) is the deuterium labeled 5-Methyl-1H-benzotriazole (HY-W086988). 5-Methyl-1H-benzotriazole is a biological material or organic compound that can be used in life science research .
|
-
- HY-158995S
-
|
3α-Glycyrrhetic acid-d<sub>2sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Epiglycyrrhetinic acid-d2 (3α-Glycyrrhetic acid-d2) is the deuterium-labeled 3-Epiglycyrrhetinic acid. 3-Epiglycyrrhetinic acid is a derivative of glycyrrhetic acid. Glycyrrhetic acid and its derivative are considered to have anti-inflammatory, anti-ulcer, and antiviral activities .
|
-
- HY-W343292S1
-
-
- HY-107494S2
-
-
- HY-12515CS1
-
-
- HY-W016152S
-
|
m-Methoxyphenyl bromide-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-3-methoxybenzene-d3 is the deuterium labeled 1-Bromo-3-methoxybenzene. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-169892S
-
|
4-HNE-GSH-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
4-Hydroxy Nonenal Glutathione-d3 (4-HNE-GSH-d3) is deuterium labeled 4-Hydroxy Nonenal Glutathione .
|
-
- HY-W040233S
-
|
(S)-2-Hydroxypropanoic acid-d<sub>3sub> sodium
|
Isotope-Labeled Compounds
|
Others
|
|
Sodium (S)-2-hydroxypropanoate-d3 is the deuterium labeled Sodium (S)-2-hydroxypropanoate[1].
|
-
- HY-113371AS
-
-
- HY-I0705S
-
|
2-Bromopropionic Acid Ethyl Ester-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Ethyl 2-bromopropionate-d3 is the deuterium labeled Ethyl 2-bromopropionate[1].
|
-
- HY-U00050S
-
|
E-10-OH-NT-d<sub>3sub>
|
Isotope-Labeled Compounds
Drug Metabolite
|
Neurological Disease
|
|
(E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
|
-
- HY-113441S
-
|
MHPG sulfate-d<sub>3sub> potassium
|
Isotope-Labeled Compounds
|
Others
|
|
3-Methoxy-4-Hydroxyphenylglycol sulfate-d3 potassium is the deuterium labeled 3-Methoxy-4-Hydroxyphenylglycol sulfate potassium[1].
|
-
- HY-137083S
-
|
UGT1A4-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Trifluoperazine N-glucuronide-d3 is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation[1].
|
-
- HY-B2227BS1
-
|
Lactic acid-d<sub>3sub> sodium
|
Isotope-Labeled Compounds
|
Others
|
|
Lactate-d3 sodium (60% in water) is the deuterium labeled Lactate sodium (60% in water). Lactate sodium (60% in water) is the product of glycogenolysis and glycolysis. Lactate sodium (60% in water) functions in a variety of biochemical processes .
|
-
- HY-W654126
-
|
Cytosine β-D-arabinofuranoside--13C<sub>3sub>; Cytosine Arabinoside--13C<sub>3sub>; Ara-C-13C<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Cytarabine- 13C3 (Cytosine β-D-arabinofuranoside- 13C3) is 13C labeled Cytarabine .
|
-
- HY-16973S
-
|
A1443-13C<sub>2sub>,15N,d<sub>3sub>; AH252723-13C<sub>2sub>,15N,d<sub>3sub>
|
Isotope-Labeled Compounds
Parasite
|
Infection
|
|
Fluralaner- 13C2, 15N,d3 is the deuterium, 13C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
|
-
- HY-W097453S2
-
-
- HY-W091636S
-
|
3,3'-Iminodipropionic acid-d<sub>8sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3,3'-Azanediyldipropionic acid-d8 is the deuterium labeled 3,3'-Azanediyldipropionic acid[1].
|
-
- HY-W009719S
-
|
2,3-DICHLOROBROMOBENZENE-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-2,3-dichlorobenzene-d3 is the deuterium labeled 1-Bromo-2,3-dichlorobenzene[1].
|
-
- HY-W010420S
-
-
- HY-B0330S2
-
-
- HY-W012689S
-
|
Dimethylolpentane-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Methyl-2-propylpropane-1,3-diol-d3 is the deuterium labeled 2-Methyl-2-propylpropane-1,3-diol[1].
|
-
- HY-W011883S
-
|
3,5-DIBROMOFLUOROBENZENE-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
1,3-Dibromo-5-fluorobenzene-d3 is the deuterium labeled 1,3-Dibromo-5-fluorobenzene[1].
|
-
- HY-W015855S
-
-
- HY-W099915S
-
-
- HY-N7092S22
-
|
D(-)-Fructose-13C<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
D-Fructose- 13C3 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-78131S1
-
-
- HY-78985S
-
|
Trimesic acid-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Benzene-1,3,5-tricarboxylic acid-d3 is the deuterium labeled Benzene-1,3,5-tricarboxylic acid[1].
|
-
- HY-W354610S
-
|
N-Vanillyloctadecanamide-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N-(4-Hydroxy-3-methoxybenzyl)stearamide-d3 is the deuterium labeled N-(4-hydroxy-3-methoxybenzyl)stearamide[1].
|
-
- HY-B0762S
-
|
O-Acetyl-L-carnitine-d<sub>3sub> (hydrochloride)
|
Endogenous Metabolite
|
Neurological Disease
|
|
Acetyl-L-carnitine-d3 (hydrochloride) is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders[1].
|
-
- HY-20386S
-
|
N,N-Dimethylchloroacetamide-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Chloro-N,N-dimethylacetamide-d3 is the deuterium labeled 2-Chloro-N,N-dimethylacetamide[1].
|
-
- HY-133685S
-
|
C6-HSL-d<sub>3sub>
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
N-Hexanoyl-L-Homoserine lactone-d3 (C6-HSL-d3) is deuterium labeled N-Hexanoyl-L-homoserine lactone. N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats .
|
-
- HY-W012615S
-
|
N-Methyl-4-anisidine-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
4-Methoxy-N-methylaniline-d3 (N-Methyl-4-anisidine-d3) is the deuterium labeled 4-Methoxy-N-methylaniline.
|
-
- HY-W010529S
-
-
- HY-W045058S
-
|
P-Bromo-N-methylanline-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
4-Bromo-N-methylaniline-d3 (P-Bromo-N-methylanline-d3) is the deuterium labeled 4-Bromo-N-methylaniline.
|
-
- HY-B0251S1
-
|
Epoxymexrenone-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Mineralocorticoid Receptor
Endogenous Metabolite
|
Cardiovascular Disease
Cancer
|
|
Eplerenone- 13C,d3 (Epoxymexrenone- 13C,d3) is 13C labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
|
-
- HY-W009981S
-
|
2,4-Difluorobromobenzene-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-2,4-difluorobenzene-d3 is the deuterium labeled 1-Bromo-2,4-difluorobenzene[1].
|
-
- HY-B0158S6
-
|
Cytosine β-D-riboside-15N<sub>3sub>; Cytosine-1-β-D-ribofuranoside-15N<sub>3sub>
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Neurological Disease
|
|
Cytidine- 15N3 is the 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
|
-
- HY-117171S
-
|
6-Iodo-2-propoxy-d<sub>7sub>-3-propyl-4(3H)-quinazolinone; Proquinazid-d<sub>7sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Proquinazid-(propoxy-d7) (6-Iodo-2-propoxy-d7-3-propyl-4(3H)-quinazolinone) is deuterium labeled Proquinazid .
|
-
- HY-B0712S1
-
|
Ro 13-9904-13C<sub>2sub>,d<sub>3sub> triethylammonium salt
|
Antibiotic
Aurora Kinase
GSK-3
Bacterial
Isotope-Labeled Compounds
|
Infection
Inflammation/Immunology
Cancer
|
|
Ceftriaxone- 13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .
|
-
- HY-B0192S1
-
-
- HY-14854S
-
|
ATI-5923-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
VKOR
|
Cardiovascular Disease
|
|
Tecarfarin- 13C,d3 (ATI-5923- 13C,d3) is 13C labeled Tecarfarin. Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X . Tecarfarin has the antithrombotic activity .
|
-
- HY-10159S1
-
-
- HY-106827S1
-
|
RU 27987-13C,d<sub>3sub>
|
Androgen Receptor
Phosphatase
Progesterone Receptor
Isotope-Labeled Compounds
|
Endocrinology
|
|
Trimegestone- 13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .
|
-
- HY-114370S
-
|
LOXO-292-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Selpercatinib- 13C,d3 (LOXO-292- 13C,d3) is 13C labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity .
|
-
- HY-147338S
-
|
5-Methyl-CTP-d<sub>3sub> trisodium
|
DNA/RNA Synthesis
Isotope-Labeled Compounds
|
Others
|
|
5-Methylcytidine 5′-triphosphate-d3 trisodium is the deuterium labeled 5-Methylcytidine 5’-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5′-triphosphate trisodium can apply in replacing unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells .
|
-
- HY-W653977
-
|
7-Chlorotetracycline-13C,d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Parasite
|
Infection
|
|
Chlortetracycline-13C,d3 hydrochloride (7-Chlorotetracycline-13C,d3 hydrochloride) is the 13C- and deuterium labeled Chlortetracycline hydrochloride (HY-B1327). Chlortetracycline hydrochloride is an orally active, selective antibiotic, that inhibits methanogenic bacteria through inhibition of bacterial protein synthesis. Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, that inhibits binding of aminoacyl-tRNA to ribosomes .
|
-
- HY-16060S2
-
|
ARN-509-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Androgen Receptor
|
Cancer
|
|
Apalutamide- 13C,d3 is the 13C- and deuterium labeled Apalutamide. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].
|
-
- HY-10065S
-
|
AG-013736-13C，d<sub>3sub>
|
VEGFR
PDGFR
|
Cancer
|
|
Axitinib- 13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50 values of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively .
|
-
- HY-12009S
-
|
GW786034-13C,d<sub>3sub> hydrochloride
|
VEGFR
PDGFR
Autophagy
c-Fms
FGFR
c-Kit
|
Cancer
|
|
Pazopanib- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
|
-
- HY-14655S1
-
-
- HY-10888S
-
|
KW-6002-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Adenosine Receptor
|
Neurological Disease
|
|
Istradefylline- 13C,d3 is the 13C- and deuterium labeled Istradefylline. Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
|
-
- HY-17034BS1
-
|
MPV785-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Endocrinology
|
|
Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .
|
-
- HY-W012832S
-
-
- HY-B0374AS
-
|
BDF5895-13C,d<sub>3sub> hydrochloride
|
Imidazoline Receptor
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Moxonidine- 13C,d3 hydrochloride is 13C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) hydrochloride is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.
|
-
- HY-10208S1
-
|
GW786034-13C,d<sub>3sub>
|
VEGFR
PDGFR
Autophagy
FGFR
c-Kit
|
Cancer
|
|
Pazopanib- 13C,d3 is the deuterium and 13C labeled Pazopanib[1]. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
|
-
- HY-14369S
-
-
- HY-15651S
-
-
- HY-16767S1
-
|
MK-1439-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
HIV
Reverse Transcriptase
|
Infection
|
|
Doravirine-13C,d3 (MK-1439-13C,d3) is the deuterium labeled Doravirine (HY-16767). Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively .
|
-
- HY-10284S1
-
|
BI 1356-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Dipeptidyl Peptidase
Autophagy
Ferroptosis
|
Metabolic Disease
|
|
Linagliptin- 13C,d3 is the 13C- and deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. Linagliptin-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-A0166S
-
|
MK0791-15N,d<sub>3sub>
|
Bacterial
Antibiotic
|
Infection
|
|
Cilastatin- 15N,d3 is a 15N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct[1][2][3].
|
-
- HY-10353AS1
-
-
- HY-A0023AS
-
-
- HY-B0165AS
-
-
- HY-B0113S3
-
|
H 16868-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Proton Pump
Autophagy
Bacterial
Phospholipase
|
Infection
Metabolic Disease
Cancer
|
|
Omeprazole- 13C,d3 is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].
|
-
- HY-B0740S1
-
-
- HY-10582S2
-
|
dl-Flurbiprofen-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Flurbiprofen- 13C,d3 is the 13C- and deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
|
-
- HY-W086901S
-
-
- HY-B0103AS2
-
-
- HY-B0596S
-
-
- HY-15605S
-
|
LGX818-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Raf
|
Cancer
|
|
Encorafenib- 13C,d3 is the 13C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).
|
-
- HY-12530S3
-
|
GS-5816-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
|
Infection
Inflammation/Immunology
Cancer
|
|
Velpatasvir- 13C,d3 (GS-5816- 13C,d3) is 13C and deuterium labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
|
-
- HY-17492S1
-
-
- HY-B0656AS3
-
|
LY307640-13C,d<sub>3sub> sodium
|
Isotope-Labeled Compounds
Apoptosis
Bacterial
Proton Pump
|
Inflammation/Immunology
Cancer
|
|
Rabeprazole- 13C,d3 (sodium) (LY307640- 13C,d3 (sodium)) is 13C labeled Rabeprazole (sodium). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .
|
-
- HY-W018728S
-
-
- HY-10805S
-
-
- HY-15408S
-
|
SYR-472-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Dipeptidyl Peptidase
|
Metabolic Disease
|
|
Trelagliptin-13C,d3 is a deuterated labeled Trelagliptin . Trelagliptin (SYR-472) is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM) .
|
-
- HY-111772S
-
-
- HY-18252S
-
-
- HY-W700793
-
|
3-Trifluoromethyl-2-methylaniline-d<sub>3sub>
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
2-Methyl-3-(trifluoromethyl)aniline-d3 (3-Trifluoromethyl-2-methylaniline-d3) is deuterium labeled 2-Methyl-3-(trifluoromethyl)aniline. 2-Methyl-3-(trifluoromethyl)aniline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-17396S
-
|
KP363-13C,d<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
Fungal
Antibiotic
|
Infection
|
|
Butenafine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
|
-
- HY-50904S1
-
|
BIBF 1120-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
PDGFR
VEGFR
FGFR
|
Cancer
|
|
Nintedanib- 13C,d3 is the 13C- and deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
|
-
- HY-B0621S1
-
-
- HY-B0656S1
-
|
LY307640-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Proton Pump
Bacterial
Apoptosis
|
Cancer
|
|
Rabeprazole-13C,d3 is a deuterated labeled Rabeprazole . Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .
|
-
- HY-113050SA
-
|
2,3-DPG-d<sub>3sub> ammonium
|
Isotope-Labeled Compounds
Parasite
|
Infection
Neurological Disease
|
|
2,3-Diphosphoglyceric acid-d3 ammonium (2,3-DPG-d3 ammonium) is the deuterium labeled 2,3-Diphosphoglyceric acid (HY-113050). 2,3-Diphosphoglyceric acid (2,3-DPG) is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2, 3-diphosphoglyceric acid has antiparasitic activity. 2,3-Diphosphoglyceric acid can be used in the study of Alzheimer's disease (AD) .
|
-
- HY-B0227S2
-
|
RP-19583-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
COX
Apoptosis
|
Inflammation/Immunology
|
|
Ketoprofen- 13C,d3 is the 13C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
|
-
- HY-13955S2
-
-
- HY-17016S3
-
|
GS 4104-13C,d<sub>3sub> phosphate
|
Isotope-Labeled Compounds
Influenza Virus
|
Infection
Cancer
|
|
Oseltamivir- 13C,d3 (phosphate) (GS 4104- 13C,d3 (phosphate)) is 13C labeled Oseltamivir (phosphate). Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
|
-
- HY-10121S4
-
-
- HY-17506S1
-
-
- HY-N0537S12
-
-
- HY-B0158S5
-
|
Cytosine β-D-riboside-13C<sub>9sub>,15N<sub>3sub>; Cytosine-1-β-D-ribofuranoside-13C<sub>9sub>,15N<sub>3sub>
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Neurological Disease
|
|
Cytidine- 13C9, 15N3 is the 13C and 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
|
-
- HY-A0132S14
-
|
N-Acetyl-2-amino-2-deoxy-D-glucose-d<sub>3sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
Drug Derivative
Interleukin Related
Drug Isomer
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
N-Acetyl-D-glucosamine-d3 (N-Acetyl-2-amino-2-deoxy-D-glucose-d3) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .
|
-
- HY-66011AS4
-
|
BAY 12-8039-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Moxifloxacin- 13C,d3 hydrochloride (BAY 12-8039- 13C,d3) is 13C and deuterated labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.
|
-
- HY-W012927S
-
-
- HY-W140887S
-
-
- HY-136450S1
-
|
TCBZ-SO-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Parasite
BCRP
|
Infection
|
|
Triclabendazole sulfoxide- 13C,d3 is the 13C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
|
-
- HY-50667S
-
|
BMS-562247-01-13C,d<sub>3sub>
|
Factor Xa
|
Cardiovascular Disease
|
|
Apixaban- 13C,d3 is a deuterium and 13C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1].
|
-
- HY-W110726S1
-
|
Pentyl Vinyl Ketone (stabilized with BHT)-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Octen-3-one-d3 is deuterated labeled 3-Ethyl-2,5-dimethylpyrazine.
|
-
- HY-W014431S
-
|
3-Fluoro-5-bromochlorobenzene-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
1-Bromo-3-chloro-5-fluorobenzene-d3 is the deuterium labeled 1-Bromo-3-chloro-5-fluorobenzene[1].
|
-
- HY-W001260S
-
|
4-Cyano-2-fluorobenzyl alcohol-d<sub>2sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Fluoro-4-(hydroxymethyl)benzonitrile-d2 is the deuterium labeled 3-Fluoro-4-(hydroxymethyl)benzonitrile (HY-W001260).
|
-
- HY-W142921S
-
-
- HY-10250S
-
-
- HY-W021008S
-
|
Dimethylhydroxyfuranone-d<sub>2sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Hydroxy-4,5-dimethylfuran-2(5H)-one-d2 is deuterated labeled 4-Ethyl-2-methoxyphenol.
|
-
- HY-W023443S
-
|
2-Methyl-5-(1-methylethyl)pyrazine-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Isopropyl-5-methylpyrazine-d3 is deuterated labeled 5-Butyldihydrofuran-2(3H)-one.
|
-
- HY-B0762S1
-
|
O-Acetyl-L-carnitine-d<sub>3sub>-1 (hydrochloride)
|
Endogenous Metabolite
|
Neurological Disease
|
|
Acetyl-L-carnitine-d3-1 (hydrochloride) is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders[1].
|
-
- HY-W017310S
-
|
3-Bromo-1,2-propanediol-d<sub>5sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Bromopropane-1,2-diol-d5 is the deuterium labeled 3-Bromopropane-1,2-diol(HY-W017310) .
|
-
- HY-10201S2
-
|
Bay 43-9006-13C,d<sub>3sub>
|
Raf
VEGFR
FLT3
Autophagy
Apoptosis
Ferroptosis
|
Cancer
|
|
Sorafenib- 13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].
|
-
- HY-N7092S23
-
|
D(-)-Fructose-13C<sub>3sub>-1
|
Isotope-Labeled Compounds
|
Others
|
|
D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
|
-
- HY-W010153S
-
-
- HY-10331S1
-
|
BAY 73-4506-13C,d<sub>3sub>
|
VEGFR
Autophagy
PDGFR
Raf
RET
|
Cancer
|
|
Regorafenib- 13C,d3 is the 13C- and deuterium labeled Regorafenib. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively.
|
-
- HY-Y0659S
-
|
1,2,3,4-Tetrahydroquinoline-d<sub>2sub>; 3,4-Dihydro-2H-quinoline-d<sub>2sub>
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4-Hydroquinoline-d2 (1,2,3,4-Tetrahydroquinoline-d2) is the deuterium labeled 1,2,3,4-Hydroquinoline.
|
-
- HY-W014423S1
-
|
H-His-OH-13C<sub>6sub>,15N<sub>3sub>,d<sub>5sub> hydrochloride hydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Histidine- 13C6, 15N3,d5 (hydrochloride hydrate) is the deuterium, 13C-, and 15-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-137522S
-
|
3'-Azido-3'-deoxythymidine β-D-glucuronide-d<sub>3sub> sodium
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Zidovudine O-β-D-glucuronide-d3 (sodium) (3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 (sodium)) is a deuterium labeled Zidovudine O-β-D-glucuronide (sodium) (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .
|
-
- HY-148682S2
-
|
Glycyrrhetic acid 3-O-hydrogen sulfate-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
18β-Glycyrrhetyl-3-O-sulfate-d3 is the deuterium labeled 18β-Glycyrrhetyl-3-O-sulfate (HY-148682)[1].
|
-
- HY-W019726S1
-
|
BAY-b 4759-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
Drug Metabolite
|
Cancer
|
|
Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine . Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .
|
-
- HY-W131180S
-
|
2,3,5,6-Tetrachlor-anilin-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2,3,5,6-Tetrachloroaniline-d3 is the deuterium labeled 2,3,5,6-Tetrachloroaniline[1].
|
-
- HY-A0023AS2
-
-
- HY-W192474S
-
-
- HY-W013948S
-
|
Propanal, (2,4-dinitrophenyl)hydrazone-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
1-(2,4-Dinitrophenyl)-2-propylidenehydrazine-d3 is the deuterium labeled 1-(2,4-Dinitrophenyl)-2-propylidenehydrazine[1].
|
-
- HY-W246043
-
|
Ethyl Nicotinate-d<sub>4sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Pyridine-2,4,5,6-d4 -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-d4-carboxylic acid, ethyl ester[1].
|
-
- HY-14781S1
-
-
- HY-W343538S
-
|
Methyl-(2-methyl-3-furyl)disulfide-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Methyl-3-(methyldisulfanyl)furan-d3 is deuterated labeled 5-Octyldihydrofuran-2(3H)-one.
|
-
- HY-W777599
-
|
(Rac)-Naproxen-13C,d<sub>3sub>-1
|
Isotope-Labeled Compounds
|
Others
|
|
(±)-Naproxen- 13C,d3-1 ((Rac)-Naproxen- 13C,d3-1) is 13C and deuterium labeled (±)-Naproxen .
|
-
- HY-W749691
-
|
(S)-GS-5816-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
SARS-CoV
HCV
|
Infection
Inflammation/Immunology
Cancer
|
|
(S)-Velpatasvir- 13C,d3 ((S)-GS-5816- 13C,d3) is 13C labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
|
-
- HY-W259250S
-
|
2-AMino-5-chloropyridine--d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
5-Chloropyridin-3,4,6-d3-2-amine is the deuterium labeled 5-Chloropyridin-2-amine[1].
|
-
- HY-B0640S
-
|
WAL801-13C,d<sub>3sub> hydrobromide
|
Isotope-Labeled Compounds
Histamine Receptor
|
Inflammation/Immunology
Endocrinology
|
|
Epinastine- 13C,d3 (hydrobromide) is the 13C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action[1][2][3][4].
|
-
- HY-W097453S
-
-
- HY-Z1430S
-
|
(3R,4S)-BRL29060-d<sub>4sub> hydrochloride; (3R,4S)-BRL29060A-d<sub>4sub>
|
Drug Metabolite
Isotope-Labeled Compounds
|
Others
|
|
Paroxetine EP impurity D-d4 (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity).
|
-
- HY-W010319S
-
|
CGA-150829-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-Amino-4-methoxy-6-methyl-1,3,5-triazine-d3 (CGA-150829-d3) is deuterium labeled 2-Amino-4-methoxy-6-methyl-1,3,5-triazine .
|
-
- HY-W099116S
-
|
Ultraviolet absorbent UV-1-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Ethyl 4-(((methyl(phenyl)amino)methylene)amino)benzoate-d3 (Ultraviolet absorbent UV-1-d3) is deuterium labeled Ethyl 4-(((methyl(phenyl)amino)methylene)amino)benzoate .
|
-
- HY-W176660S
-
-
- HY-124215S1
-
|
DL-1,3,3-trimethylbicyclo[2.2.1]heptan-2-one-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Fenchone-d3 is deuterated labeled Benzo[pqr]tetraphen-3-ol (HY-W585890).
|
-
- HY-Z5058S
-
-
- HY-14664CS
-
|
(3S,5R)-XU 62-320-d<sub>6sub>
|
HMG-CoA Reductase (HMGCR)
|
Cardiovascular Disease
Cancer
|
|
(3S,5R)-Fluvastatin-d6 (sodium) is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].
|
-
- HY-10002S
-
-
- HY-32350S
-
-
- HY-N0229S5
-
|
L-2-Aminopropionic acid-13C<sub>3sub>,15N,d<sub>4sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Neurological Disease
Metabolic Disease
|
|
L-Alanine- 13C3, 15N,d4 is the deuterium, 13C-, and 15-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-108226S
-
|
N-Desmethyl regorafenib N-oxide-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Regorafenib N-oxide and N-desmethyl (M5)-d3 is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).
|
-
- HY-W010555S
-
|
2-Hydroxy-3-methyl-2-cyclopenten-1-one-d<sub>6sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Methylcyclopentane-1,2-dione-d6 is deuterated labeled 5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one.
|
-
- HY-W701842
-
|
1-Oleoyl-3-chloropropanediol-d<sub>5sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Chloro-2-hydroxypropyl-1,1,2,3,3-d5 oleate (1-Oleoyl-3-chloropropanediol-d5) is deuterium labeled 3-Chloro-2-hydroxypropyl-1,1,2,3,3 oleate .
|
-
- HY-131325S
-
|
N2,N4-Diethyl-6-(methoxy-d<sub>3sub>)-1,3,5-triazine-2,4-diamine
|
Isotope-Labeled Compounds
|
Others
|
|
Simeton-d3 (N2,N4-Diethyl-6-(methoxy-d3)-1,3,5-triazine-2,4-diamine) is deuterium labeled Simeton .
|
-
- HY-W102449S
-
|
1-(4-(Methylamino)phenyl)ethanone-13C,d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
4-Acetyl-N-methylaniline-13C,d3 (1-(4-(Methylamino)phenyl)ethanone-13C,d3) is a 13C and deuterated isotope of 4-Acetyl-N-methylaniline. Compounds labeled with stable or radioactive isotopes can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-167592S
-
|
1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(-d<sub>5sub>)-3-phospho- L-serine sodium
|
Isotope-Labeled Compounds
|
Others
|
|
17:0-20:3 PS-d5 (1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d5)-3-phospho- L-serine (sodium)) is deuterium labeled 17:0-20:3 PS .
|
-
- HY-W016749S
-
|
Ac-DL-Asp-OH-2,3,3-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N-Acetyl-DL-aspartic acid-2,3,3-d3 is the deuterium labeled N-Acetyl-DL-aspartic acid-2,3,3[1].
|
-
- HY-167583S
-
|
1-heptadecanoyl-2-eicosatrienoyl-sn-glycero(-d<sub>5sub>)-3-phosphoinositol ammonium
|
Isotope-Labeled Compounds
|
Others
|
|
17:0-20:3 PI-d5 (1-heptadecanoyl-2-eicosatrienoyl-sn-glycero(d5)-3-phosphoinositol (ammonium)) is deuterium labeled 17:0-20:3 PI .
|
-
- HY-W722289S
-
|
N-(2-(Ethyl-2,2,2-d<sub>3sub>)-6-methylphenyl)-2-aminopropanoic acid
|
Isotope-Labeled Compounds
|
Others
|
|
(rac)-Metolachlor metabolite CGA 50267-d3 (N-(2-(Ethyl-2,2,2-d3)-6-methylphenyl)-2-aminopropanoic acid) is deuterium labeled (2-Ethyl-6-methylphenyl)alanine .
|
-
- HY-W289054S
-
|
2-((2-(Ethyl-2,2,2-d<sub>3sub>)-6-methylphenyl)amino)-2-oxoacetic acid
|
Isotope-Labeled Compounds
|
Others
|
|
(S)-Metolachlor metabolite CGA 50720-d3 (2-((2-(Ethyl-2,2,2-d3)-6-methylphenyl)amino)-2-oxoacetic acid) is deuterium labeled 2-((2-Ethyl-6-methylphenyl)amino)-2-oxoacetic acid .
|
-
- HY-150661S
-
|
3-epi-25-Hydroxy Vitamin D3-13C<sub>5sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Epi-25-hydroxyvitamin D3- 13C5 is the 13C labeled 3-Epi-25-hydroxyvitamin D3[1].
|
-
- HY-W721117
-
|
Methyl N-acetyl-S-(3-hydroxypropyl)-L-cysteinate-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine-d3 (Methyl N-acetyl-S-(3-hydroxypropyl)-L-cysteinate-d3) is the deuterium labeled N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine.
|
-
- HY-W701859
-
|
1-Oleoyl-2-Stearoyl-3-chloropropanediol-d<sub>5sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Chloro-2-(stearoyloxy)propyl-1,1,2,3,3-d5 oleate (1-Oleoyl-2-Stearoyl-3-chloropropanediol-d5) is deuterium labeled 3-Chloro-2-(stearoyloxy)propyl-1,1,2,3,3 oleate .
|
-
- HY-W714705S
-
|
Sodium 2-((2-(ethyl-2,2,2-d<sub>3sub>)-6-methylphenyl)amino)-2-oxoethane-1-sulfonate
|
Isotope-Labeled Compounds
|
Others
|
|
(S)-Metolachlor metabolite CGA 368208-d3 sodium salt (Sodium 2-((2-(ethyl-2,2,2-d3)-6-methylphenyl)amino)-2-oxoethane-1-sulfonate) is deuterium labeled Sodium 2-((2-ethyl-6-methylphenyl)amino)-2-oxoethane-1-sulfonate .
|
-
- HY-69188S
-
|
3,4-Dihydro-2H-1,4-benzothiazine-d<sub>2sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3,4-Dihydro-2H-benzo[b][1,4]thiazine-d2 (3,4-Dihydro-2H-1,4-benzothiazine-d2) is the deuterium labeled 3,4-Dihydro-2H-benzo[b][1,4]thiazine.
|
-
![3,4-Dihydro-2H-benzo[b][1,4]thiazine-d2](//file.medchemexpress.eu/product_pic/hy-69188s.gif)
- HY-146836S1
-
|
1,2-dipalmitoyl-rac-glycero(-d<sub>5sub>)-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium salt
|
Isotope-Labeled Compounds
|
Others
|
|
16:0 PI(5)P-d5 (ammonium) is the deuterium labeled 16:0 PI(5)P (ammonium) .
|
-
- HY-W144430S
-
|
2-[3-(Trifluoromethyl)phenoxy]pyridine-3-carboxylic acid, 3-[(3-Carboxypyridin-2-yl)oxy]benzotrifluoride-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-[3-(Trifluoromethyl)phenoxy]nicotinic acid-d3 (2-[3-(Trifluoromethyl)phenoxy]pyridine-3-carboxylic acid, 3-[(3-Carboxypyridin-2-yl)oxy]benzotrifluoride-d3) is deuterium labeled 2-[3-(Trifluoromethyl)phenoxy]nicotinic acid .
|
-
![2-[3-(Trifluoromethyl)phenoxy]nicotinic acid-d3](//file.medchemexpress.eu/product_pic/hy-w144430s.gif)
- HY-131332S1
-
|
(11β)-11-[4-(Methylamino)phenyl]-3,20-dioxo-19-norpregna-4,9-dien-17-yl acetate-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
N-Desmethyl ulipristal-d3 ((11β)-11-[4-(Methylamino)phenyl]-3,20-dioxo-19-norpregna-4,9-dien-17-yl-d3) acetate is deuterium labeled N-Desmethyl ulipristal acetate ((11β)-11-[4-(Methylamino)phenyl]-3,20-dioxo-19-norpregna-4,9-dien-17-yl) .
|
-
- HY-A0132S9
-
|
N-Acetyl-2-amino-2-deoxy-D-glucose-13C<sub>3sub>,15N
|
Endogenous Metabolite
|
Metabolic Disease
|
|
N-Acetyl-D-glucosamine- 13C3, 15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-W128255S1
-
|
2-(4,6-Diphenyl-1,3,5-triazine-2-yl)-5-methoxy-xyphenol-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
2-(4,6-Diphenyl-1,3,5-triazin-2-yl)-5-methoxyphenol-d3 (2-(4,6-Diphenyl-1,3,5-triazine-2-yl)-5-methoxy-xyphenol-d3) is deuterium labeled 2-(4,6-Diphenyl-1,3,5-triazin-2-yl)-5-methoxyphenol .
|
-
- HY-W654262
-
|
((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity)-d<sub>3sub>
|
Isotope-Labeled Compounds
|
Others
|
|
10α-Methoxy-9,10-dihydrolysergol-d3 is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .
|
-
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B1773AS5
-
|
|
|
Sodium Propionate-d3 is the deuterium labeled Sodium Propionate[1].
|
-
-
- HY-113323S
-
|
|
|
3-Methoxy-4-hydroxyphenylglycol-d3 is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol.
|
-
-
- HY-B0113S
-
1 Publications Verification
|
|
Omeprazole-d3 is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].
|
-
-
- HY-W008794S
-
|
|
|
Normetanephrine-d3 (hydrochloride) is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE)[1].
|
-
-
- HY-66005S1
-
|
|
|
Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].
|
-
-
- HY-B1689AS
-
|
|
|
Methantheline-d3 (bromide) is the deuterium labeled Methantheline bromide[1].
|
-
-
- HY-17413S
-
|
|
|
Zidovudine-d3 is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
|
-
-
- HY-B0607S
-
|
|
|
Nitisinone-d3 (NTBC-d3) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .
|
-
-
- HY-B0715S3
-
|
|
|
Pentoxifylline-d3 (BL-191-d3) is deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .
|
-
-
- HY-B0457AS
-
|
|
|
Clomipramine-d3 is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].
|
-
-
- HY-B0141AS
-
|
|
|
Alpha-Estradiol-d3 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
|
-
-
- HY-N0176S
-
|
|
|
Dihydroartemisinin-d3 is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.
|
-
-
- HY-13756S2
-
|
|
|
Tacrolimus-d3 (FK506-d3) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
|
-
-
- HY-30151S
-
|
|
|
Methoxsalen-d3 is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].
|
-
-
- HY-15330
-
|
|
|
Vitamin D2-d3 (Ergocalciferol-d3) is the deuterium labeled vitamin D2.
|
-
-
- HY-13777S1
-
|
|
|
Zoledronic acid-d3 is the deuterium labeled Zoledronic acid .
|
-
-
- HY-B0479S
-
|
|
|
Thiamphenicol-d3 is a deuterium labeled Thiamphenicol. Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].
|
-
-
- HY-N0108S
-
|
|
|
Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .
|
-
-
- HY-B0171S
-
|
|
|
Antipyrine-d3 is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity[1][2].
|
-
-
- HY-N0136S
-
|
|
|
Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
|
-
-
- HY-B1110S
-
|
|
|
Nomifensine-d3 ((±)-Nomifensine-d3) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .
|
-
-
- HY-B1279AS
-
|
|
|
Metamizole-d3 sodium is the deuterium labeled Metamizole sodium. Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole sodium is a cyclooxygenase-3 (COX-3) inhibitor .
|
-
-
- HY-13757AS1
-
|
|
|
Tamoxifen-d3 is the deuterium labeled Tamoxifen . Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse .
|
-
-
- HY-13757S
-
|
|
|
Tamoxifen-d3 hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .
|
-
-
- HY-10082S1
-
|
|
|
Triapine-d3 (3-AP-d3) is deuterium labeled Triapine. Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.
|
-
-
- HY-B1658S
-
|
|
|
Frovatriptan-d3 (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].
|
-
-
- HY-15027S1
-
|
|
|
5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].
|
-
-
- HY-W001158S1
-
|
|
|
N,N-Dimethylglycine-d3 (Dimethylglycine-d3) hydrochloride is the deuterium labeled N,N-Dimethylglycine hydrochloride (HY-W001158). N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects .
|
-
-
- HY-13636S
-
|
|
|
Fulvestrant-d3 is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].
|
-
-
- HY-17509S
-
|
|
|
Deracoxib-d3 is the deuterium labeled Deracoxib. Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).
|
-
-
- HY-B0264S
-
|
|
|
Guaifenesin-d3 is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].
|
-
-
- HY-N0005S1
-
|
|
|
Curcumin-d3 (Diferuloylmethane-d3 ) is deuterium labeled Curcumin. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
|
-
-
- HY-B0579S1
-
|
|
|
Cyclosporin A-d3 is the d3-labeled Cyclosporin A (HY-B0579)[1].
|
-
-
- HY-15202S1
-
|
|
|
Binimetinib-d3 (MEK162-d3) is deuterium labeled Binimetinib. Binimetinib (MEK162) is an oral and selective MEK1/2 inhibitor. Binimetinib (MEK162) inhibits MEK with an IC50 of 12 nM .
|
-
-
- HY-10581AS
-
|
|
|
Gatifloxacin-d3 (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
|
-
-
- HY-B1260S2
-
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Cetrimonium-d3 (bromide) is the deuterium labeled Cetrimonium bromide[1].
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- HY-15027S
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5-Aminosalicylic Acid-d3 (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
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- HY-B0647S1
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Butylphthalide-d3 is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.
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- HY-115127S
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3-Methylanisole-d3 is the deuterium labeled 3-Methylanisole[1].
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- HY-A0070AS3
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Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively .
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- HY-70002S
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Deutenzalutamide (Enzalutamide-d3) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .
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- HY-41700S
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D-Alanine-d3 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
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- HY-15455S2
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Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
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- HY-B0215S
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Acetylcysteine-d3 is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .
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- HY-B0389S7
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D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-113015S
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Stearoylethanolamide-d3 (Ceamid-d3) is deuterium labeled Stearoylethanolamide. Stearoylethanolamide is an endocannabinoid-like compound with pro-apoptotic activity .
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- HY-127165S1
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Velnacrine-d3 (maleate) is the deuterium labeled Velnacrine maleate[1].
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- HY-B0094S
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Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].
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- HY-B0105BS
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(-)-Ketoconazole-d3 is deuterium labeled (-)-Ketoconazole. (-)-Ketoconazole ((-)-R 41400) is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, levoketoconazole ((2S,4R)-(−)-ketoconazole) and dextroketoconazole ((2R,4S)-(+)-ketoconazole).
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- HY-101037S1
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Sarcosine-d3 is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].
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- HY-W654101
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Cefotaxime-d3 is the deuterium labeled Cefotaxime (HY-A0088A). Cefotaxime is the β-lactamase stable cephalosporin and the third-generation cephalosporin antibiotic. Cefotaxime possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria .
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- HY-10219S
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Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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- HY-B1374S1
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Florfenicol-d3 is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.
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- HY-B0271S
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Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].
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- HY-14654S
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Aspirin-d3 is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.
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- HY-N0054S
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Osthole-d3 (Osthol-d3) is the deuterium-labeled Osthole (HY-N0054) .
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- HY-B1037S
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Salbutamol-d3 is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).
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- HY-17021S2
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Esomeprazole-d3 potassium is deuterated labeled Esomeprazole (HY-17021). Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H +, K +-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .
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- HY-N0623S9
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L-Tryptophan-d3 is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
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- HY-15345AS
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Tetrahydrouridine-d3 is the deuterium labeled Tetrahydrouridine[1]. Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine[2][3].
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- HY-17021S1
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Esomeprazole-d3 is deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].
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- HY-121309S
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Doxorubicinone-d3 is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
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- HY-B0272S
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Rifampicin-d3 is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities[1][2].
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- HY-40354S5
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Tofacitinib-d3 (Tasocitinib-d3) is deuterium labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
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- HY-B0150S3
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Nicotinamide-d3 (Niacinamide-d3) is deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .
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- HY-N1150S
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Thymidine-d3 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1][2][3].
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- HY-A0088S
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Cefotaxime-d3 (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4][5].
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- HY-13632S2
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Exemestane-d3 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
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- HY-B1836S
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Meldonium-d3 is the deuterated form of Meldonium. Meldonium is a cardiovascular protective agent that competitively inhibits BBOX1 and OCTN2. The IC50 value of Mildronate against human recombinant BBOX is 34-62 μM, and the EC50 value against human OCTN2 is 21 μM. Meldonium is a fatty acid oxidation inhibitor .
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- HY-107855S1
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DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3].
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- HY-Y0842S1
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Formamide-d3 is the deuterium labeled Formamide. Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.
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- HY-17021S
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Esomeprazole-d3 (sodium) is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].
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- HY-B0115S
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Pizotyline-d3 is deuterated labeled Pizotifen (HY-B0115). Pizotifen (Pizotyline) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.
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- HY-15398S3
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Vitamin D3-d3 is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.
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- HY-13694S
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Methionine-d3 is the deuterium labeled Methionine. Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
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- HY-15772S3
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Asandeutertinib (Osimertinib-d3; AZD-9291-d3) is a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with antineoplastic effect .
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- HY-N0402S
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Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.
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- HY-17452AS
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Cefditoren Pivoxil-d3 (Cefditoren pivoxyl-d3) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
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- HY-B0302AS
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Etidronic acid-d3 (disodium) is the deuterium labeled Etidronic acid disodium[1].
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- HY-101064S2
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Fmoc-leucine-d3 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
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- HY-13318S
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Maximum Cited Publications
59 Publications Verification
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Oseltamivir acid-d3 is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses[1][2].
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- HY-107854S
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N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].
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- HY-B0457S
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Clomipramine-d3 (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].
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- HY-B0617S
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S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) is the deuterated product of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .
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- HY-75087S
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(R)-Pyrrolidine-2-carboxylic acid-d3 is the deuterium labeled (R)-pyrrolidine-2-carboxylic acid. (R)-pyrrolidine-2-carboxylic acid is an endogenous metabolite.
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- HY-B1189S
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Meglutol-d3 is the deuterium labeled Meglutol[1]. Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.
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- HY-W007355S
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Skatole-d3 is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].
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- HY-109171S
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Elinzanetant-d3 (NT-814-d3) is deuterium labeled Elinzanetant. Elizanetant (NT-814) is an orally active, selective NK-1,3 receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women .
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- HY-N0684S4
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Vitamin K1-d3 (Phylloquinone-d3; Phytomenadione-d3) is deuterium-labeled Vitamin K1 (HY-N0684) .
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- HY-N0650S8
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1 Publications Verification
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L-Serine-d3 is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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- HY-B0002BS1
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Ondansetron-d3 is the deuterium labeled Ondansetron[1]. Ondansetron(GR 38032;SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2].
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- HY-13683S
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Mifepristone-d3 is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].
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- HY-B1059S
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Levosulpiride-d3 is the deuterium labeled Levosulpiride. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class[1][2].
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- HY-15321S2
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Etoricoxib-d3 is the deuterium labeled Etoricoxib[1]. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood[2][3][4].
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- HY-B0352S
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Mirtazapine-d3 is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].
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- HY-14268S2
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Febuxostat-d3 (TEI 6720-d3) is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout .
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- HY-16973S4
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Fluralaner-d3 (A1443-d3) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
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- HY-B0966S
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Dioxybenzone-d3 is deuterium labeled Dioxybenzone. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study .
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- HY-17507S1
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Pantoprazole-d3 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
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- HY-12519S
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Oltipraz-d3 is the deuterium labeled Oltipraz. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
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- HY-16293S
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Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].
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- HY-B0905S
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Tilmicosin-d3 is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects .
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- HY-104074S
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Pocapavir-d3 (SCH-48973-d3; V-073-d3) is the deuterium labeled Pocapavir (HY-104074) . Pocapavir (SCH-48973) is an orally active capsid inhibitor. Pocapavir prevents virion uncoating upon entry into the cell. Pocapavir has antiviral activity against polioviruses. Pocapavir also inhibits enterovirus infections .
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- HY-15851S2
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Revefenacin-d3 (TD-4208-d3) is deuterium labeled Revefenacin. Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.
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- HY-B0801S2
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Fexofenadine-d3 is the deuterium labeled Fexofenadine[1]. Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[2][3][4].
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- HY-12785S
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Albendazole sulfoxide-d3 is deuterium labeled Albendazole sulfoxide, which is a broad-spectrum anthelmintic.
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- HY-B0469S
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Medroxyprogesterone acetate-d3 is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].
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- HY-108325S
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Brequinar-d3 (DUP785-d3) is deuterium labeled Brequinar. Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity .
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- HY-A0064S
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Verapamil-d3 (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].
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- HY-14275S
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Verapamil-d3 ((±)-Verapamil-d3) is deuterium labeled Verapamil. Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .
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- HY-A0251S
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Cefpodoxime-d3 is the deuterium labeled Cefpodoxime[1].
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- HY-50936S
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Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .
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- HY-N0156S
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Oleanolic acid-d3 is the deuterium labeled Oleanolic Acid[1]. Oleanolic acid (Caryophyllin) is a natural compound from plants with anti-tumor activities[2].
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- HY-166363S
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Beraprost-d3 (TRK-100-d3) is deuterium labeled (Rac)-Beraprost. (Rac)-Beraprost ((Rac)-ML 1229) is an orally active prostacyclin analog that inhibits the release of Ca 2+ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis .
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- HY-B1417S
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Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].
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- HY-B2137S
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S-(+)-Ketoprofen-d3 ((S)-Ketoprofen-d3) is deuterium labeled S-(+)-Ketoprofen. S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
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- HY-103395S
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Methylmalonic acid-d3 is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer[1][2].
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- HY-B0404AS
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Benserazide-d3 (hydrochloride) is the deuterium labeled Benserazide hydrochloride. Benserazide hydrochloride (Serazide) is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC)[1].
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- HY-B0495S5
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Lamotrigine-d3 is the deuterium labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].
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- HY-B1140S
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Diazoxide-d3 is deuterium labeled Diazoxide. Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.
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- HY-W004282S1
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Undecanoic acid-d3 (Undecanoate-d3) is the deuterium labeled Undecanoic acid (HY-W004282). Undecanoic acid is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .
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- HY-W759845
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Aficamten-d3 (CK-274-d3) is deuterium labeled Aficamten. Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM) .
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- HY-B0109AS
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Dorzolamide-d3 hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .
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- HY-N0682S
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Pyridoxine-d3 (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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- HY-W703549
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Aderbasib-d3 (INCB007839-d3) is deuterium labeled Aderbasib. Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2 +?breast cancer, gliomas, et al .
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- HY-B0218S
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Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .
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- HY-15315S1
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Baricitinib-d3 is the deuterium labeled Baricitinib. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
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- HY-Y1002S
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Methionol-d3 is deuterated labeled ((3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl)-L-asparagine.
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- HY-B0141S
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Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
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- HY-Y1298S1
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Methyl acetylacetate-d3 (Acetoacetate methyl ester-d3) is a deuterium labeled Methyl acetylacetate (HY-Y1298). Methyl acetylacetate is an endogenous metabolite .
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- HY-N0488S
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Vincristine-d3 (sulfate)is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1][2].
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- HY-B0021S1
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Doxifluridine-d3 is deuterated labeled Doxifluridine (HY-B0021). Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs .
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- HY-14649S5
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Retinoic acid-d3 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .
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- HY-N0488S1
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Vincristine-d3-ester (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM[1].
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- HY-17504BS2
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Rosuvastatin- 13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
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- HY-Y0084S
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3,4,5-Trimethoxybenzoic acid-d3 is the deuterium labeled 3,4,5-Trimethoxybenzoic acid[1]. 3,4,5-Trimethoxybenzoic acid (Eudesmic acid;Trimethylgallic Acid) is a benzoic acid derivative. A building block in medicine and organic synthesis.
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- HY-Y0251S
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NSC 3120-d3 is the deuterium labeled NSC 3120[1].
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- HY-B1658BS
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Frovatriptan-d3 (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].
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- HY-15027S3
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5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
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- HY-12388AS
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N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]
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- HY-B0479S1
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Thiamphenicol-d3-1 (Thiophenicol-d3-1; Dextrosulphenidol-d3-1) is the deuterium-labeled Thiamphenicol (HY-B0479) . Thiamphenicol (Thiophenicol)，a methyl-sulfonyl derivative of Chloramphenicol，is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit，leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative，Gram-positive aerobic and anaerobic bacteria) .
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- HY-12779S
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Cyantraniliprole-d3 is the deuterium labeled Cyantraniliprole, which is an insecticide of the ryanoid class.
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- HY-108506S
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Licarbazepine-d3 is the deuterium labeled Licarbazepine (HY-108506). Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects[1][2].
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- HY-Y1311S
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Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods[1][2].
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- HY-13311S
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Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively .
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- HY-12053AS
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1 Publications Verification
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Vinorelbine-d3 (ditartrate) is the deuterium labeled Vinorelbine ditartrate. Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
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- HY-N1366S
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Herniarin-d3 is the deuterium labeled Boc-Phe-CHO[1].
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- HY-17368S2
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Rivastigmine-d3 hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
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- HY-N0680S1
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Thiamine-d3 (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.
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- HY-B0809S1
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Theophylline-d3 is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .
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- HY-B2150S
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4-Hydroxyantipyrine-d3 is the deuterium labeled 4-Hydroxyantipyrine. 4-Hydroxyantipyrine is the major metabolite of Antipyrine, can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Antipyrine in the brain[1][2][3].
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- HY-15592AS
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Cabotegravir-d3 (sodium) is the deuterium labeled Cabotegravir sodium. Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltr
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- HY-70050AS
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Alosetron-d3 is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].
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- HY-127165S
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Velnacrine-d3 is the deuterium labeled Velnacrine[1].
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- HY-B0225AS
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Methyldopa-d3 (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].
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- HY-G0007S
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Omeprazole metabolite Omeprazole sulfone-d3 is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
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- HY-13629S
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Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .
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- HY-B1178S
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(Rac)-Cotinine-d3 is the deuterium labeled (Rac)-Cotinine[1].
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- HY-10163S1
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Dabigatran-d3 is the deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].
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- HY-14291S
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Vildagliptin-d3 is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity[1][2].
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- HY-14959S
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Ulipristal-d3 (CDB-3236-d3) is deuterium labeled Ulipristal. Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system .
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- HY-15463S2
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Imatinib-d3 (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.
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- HY-B0456S3
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Riboflavin-d3 is the deuterium labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
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- HY-113468AS
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3-O-Methyldopa-d3 (3-Methoxy-L-tyrosine-d3) is deuterium labeled 3-O-Methyldopa (HY-113468A). 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease .
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- HY-134127S2
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Hexacosanoic acid methyl ester-d3 (C26:0 methyl ester-d3) is deuterium labeled Methyl hexacosanoate. Methyl hexacosanoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-B0495S
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Lamotrigine- 13C3,d3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
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- HY-W654130
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Daunorubicin- 13C,d3 is 13C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .
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- HY-10512S
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AR-A014418-d3 is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM)[1].
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- HY-Y1069S
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1 Publications Verification
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(S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive[1][2].
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- HY-Y0837S
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L-Alaninol-d3 is the deuterium labeled L-Alaninol[1].
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- HY-W700927
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N-Formyl-L-leucine-d3 (N-Formyl-S-leucine-d3) is deuterium labeled N-Formyl-L-leucine. N-Formyl-L-leucine is a leucine derivative .
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- HY-79576S
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Estrone 3-methyl ether-d3 is the deuterium labeled Estrone 3-methyl ether[1].
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- HY-N0570S1
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Hydroxytyrosol-d5 is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].
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- HY-N0570S
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Hydroxytyrosol-d4 is the deuterium labeled Hydroxytyrosol. Hydroxytyrosol (DOPET) is a phenolic compound drawn from the olive tree and its leaves with anti-oxidant, anti-atherogenic, anti-thrombotic, antimicrobial, anti-inflammatory and anti-tumour effects[1][2].
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- HY-B1716S
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L-5-Hydroxytryptophan-d3 is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[2][3][4][5].
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- HY-40354AS
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Tofacitinib-d3 (citrate) is deuterium labeled Tofacitinib (citrate). Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.
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- HY-Y0219S1
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NSC 83128-d3 is the deuterium labeled NSC 83128[1].
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- HY-B1205S
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(Rac)-Atropine-d3 is the deuterium labeled (Rac)-Atropine[1].
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- HY-N0086S
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N6-Methyladenosine-d3 (6-Methyladenosine-d3; N-Methyladenosine-d3) is a deuterium labeled N6-Methyladenosine (HY-N0086). N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities.
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- HY-14648S5
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Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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- HY-B0932S
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Levocarnitine propionate-d3 (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.
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- HY-Y1275S1
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N-Methylpyrrolidone-d3 is the deuterium labeled N-Methylpyrrolidone [1]. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[2][3].
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- HY-B0471S
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Phenylephrine-d3 (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
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- HY-B0161AS
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Duloxetine-d3 (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].
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- HY-129240S
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13-cis Acitretin-d3 is a deuterium labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis[1][2].
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- HY-W701918
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Vonedrine-d3 (hydrochloride) is the deuterium labeled Vonedrine (hydrochloride) .
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- HY-B1287S
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Citalopram-d3 ((±)-Citalopram-d3) hydrobromide is deuterium labeled Citalopram (hydrobromide). Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect .
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- HY-150964S
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2 Publications Verification
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S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) methylbenzenesulfonate is the deuterium labeled S-Adenosyl-L-methionine methylbenzenesulfonate . S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .
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- HY-14649S6
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Retinoic acid-d3-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .
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- HY-G0003S1
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Iloperidone metabolite Hydroxy Iloperidone-d3 is the deuterium labeled Iloperidone metabolite Hydroxy Iloperidone[1].
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- HY-B0130AS
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Perindopril-d3 (erbumine) is deuterated labeled Perindopril (erbumine) (HY-B0130A). Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure .
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- HY-I0746S
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3-Aminobenzoic acid-d4 is the deuterium labeled 3-Aminobenzoic acid[1].
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- HY-B0352BS
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(R)-Mirtazapine-d3 is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].
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- HY-W154267S
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3-Aminoisobutyric acid-d3 (hydrochloride) is the deuterium labeled DL-Histidine[1].
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- HY-131932S
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N-Desethyl-dorzolamide-d3 hydrochloride is deuterated labeled N-Desethyl-dorzolamide.
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- HY-15029S1
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(±)-Naproxen-d3-1 is the deuterium labeled (±)-Naproxen[1].
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- HY-B0352AS
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(S)-Mirtazapine-d3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].
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- HY-B0801S4
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Fexofenadine-d3-1 fumarate is deuterated labeled Fexofenadine (HY-B0801). Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research .
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- HY-B1342S5
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Vitamin A-d3 (Vitamin A1-d3; all-trans-Retinol-d3) is a vitamin A analogue .
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- HY-78131S
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1 Publications Verification
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Ibuprofen-d3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM .
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- HY-B1057S2
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Nefopam-d3 is a deuterium labeled Nefopam (Fenazoxine). Nefopam is a centrally-acting but non-opioid analgesic drug, and Nefopam targets β-catenin protein level in mesenchymal cells[1][2].
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- HY-N6608S
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Physostigmine-d3 is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].
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- HY-D0205AS2
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Carbocisteine-d3 (Carbocysteine-d3) is deuterium labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research .
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- HY-78131CS
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1 Publications Verification
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Ibuprofen-d3 ((±)-Ibuprofen-d3) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
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- HY-124920S
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Methiocarb-d3 is the deuterium labeled Methiocarb[1].
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- HY-76299S2
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Galanthamine-d3 (Galantamine-d3) hydrochloride is deuterium-labeled Galanthamine (HY-76299) .
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- HY-N0083S
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Betulin-d3 (Trochol-d3) is deuterium labeled Betulin. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line .
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- HY-B0439S1
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Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].
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- HY-B1057S
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Nefopam-d3 (hydrochloride) is the deuterium labeled Nefopam hydrochloride. Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2].
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- HY-B0330BS1
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Levofloxacin-d3 ((-)-Ofloxacin-d3) hydrochlorideis deuterium labeled Levofloxacin (hydrochloride). Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrochloride shows anti-orthopoxvirus activity .
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- HY-107469S1
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Pyridoxal-d3 is the deuterium labeled Pyridoxal[1].
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- HY-B1328S1
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Pyridoxine-d3 is a deuterium labeled Pyridoxine. Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway .
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- HY-N0504S2
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Lovastatin-d3 is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
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- HY-N0583S3
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Hydrocortisone-d3 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].
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- HY-107469S
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Pyridoxal-d3 (hydrochloride) is the deuterium labeled Pyridoxal hydrochloride[1].
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- HY-B0251S
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Eplerenone-d3 is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch[1][2].
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- HY-77956S4
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Thyminose-d3 is the deuterium labeled Thyminose. Thyminose is an endogenous metabolite[1].
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- HY-W740078
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Picaridin-d3 (Icaidi-d3) is deuterium labeled Picaridin .
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- HY-113739S
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Desmethylcitalopram-d3 (hydrochloride) is the deuterium labeled Desmethylcitalopram hydrochloride[1].
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- HY-N0088S
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Apocynin-d3 is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].
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- HY-N0415S
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Trigonelline-d3 (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
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- HY-15206S1
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Glyburide-d3 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
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- HY-B0147S1
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Pefloxacin-d3 is the deuterium labeled Pefloxacin. Pefloxacin is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse).
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- HY-B0188S
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Mianserin-d3 is the deuterium labeled Mianserin (HY-B0188). Mianserin? is a Histamine 1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant .
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- HY-W700770
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DTAC-d3 (Dodecyltrimethylammonium-d3 chloride) is the deuterium labeled DTAC (HY-W096983). DTAC is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W016034S
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Acetaminophen glucuronide-d3 sodium salt is the deuterium labeled Acetaminophen glucuronide sodium salt.
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- HY-18569S3
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3-Indoleacetic acid-d7 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
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- HY-15592S2
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Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research
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- HY-18569S1
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3-Indoleacetic acid-d4 (Indole-3-acetic acid-d4; 3-IAA-d4) is the deuterium labeled 3-Indoleacetic acid (HY-18569) . 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
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- HY-18569S
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1 Publications Verification
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3-Indoleacetic acid-d5 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid-d5 can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates .
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- HY-N0679S
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Retinyl acetate-d3 (ALK-001) is a deuterated Vitamin A. Retinyl acetate-d3 can be used for research of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) .
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- HY-B0648S
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Medroxyprogesterone-d3 is the deuterium labeled Medroxyprogesterone. Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
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- HY-N0707S
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(S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].
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- HY-112582S
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N1-Methylpseudouridine-d3 is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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- HY-B0300S
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Penicillamine-d3 is the deuterium labeled Penicillamine. Penicillamine (D-(-)-Penicillamine) is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
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- HY-Y1770S
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2-Amino-5-bromopyridine-d3 is the deuterium labeled 2-Amino-5-bromopyridine[1].
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- HY-16938S1
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5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine[1]. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2][3][4].
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- HY-W000854S
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3-Methoxybenzeneboronic acid-d3 is the deuterium labeled 3-Methoxybenzeneboronic acid (HY-W000854). 3-Methoxybenzeneboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-135794S
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11-Ketodihydrotestosterone-d3 is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells[1][2].
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- HY-144856S1
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Sapropterin-d3 ((6R)-BH4-d3) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .
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- HY-B1716S1
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L-5-Hydroxytryptophan-d3-1 is the deuterium labeled L-5-Hydroxytryptophan[1]. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[2]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[3][4][5][6].
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- HY-W017387S
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Sodium α-ketoisocaproate-d3 is the deuterium labeled Sodium α-ketoisocaproate[1].
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- HY-17459S
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Clopidogrel-d3 (hydrogen sulfate) is the deuterium labeled Clopidogrel hydrogen sulfate[1]. Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[2][3][4][5][6].
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- HY-119521S
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Mexiletine-d3 (KOE-1173-d3) is deuterium labeled Mexiletine. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
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- HY-18204S1
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Valsartan-d3 is the deuterium labeled Valsartan[1]. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[2].
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- HY-12085S3
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Apremilast-d3 (CC-10004-d3) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM .
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- HY-A0168S
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Regadenoson-d3 is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with Kis of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents[1][2][3].
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- HY-B1743S
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3 Publications Verification
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Puromycin-d3 is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.
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- HY-N1380S1
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Guaiacol-d3 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].
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- HY-50904S
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Nintedanib-d3 is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
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- HY-N0370S
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Bergapten-d3 is deuterium labeled Bergapten. Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.
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- HY-14541S
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Olanzapine-d3 is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].
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- HY-17016S1
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Oseltamivir-d3 (phosphate)eis the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
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- HY-B0421S
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Mycophenolic acid-d3 is deuterium labeled Mycophenolic acid, which is an an immunosuppresant agent and has potent anti-proliferative activity.
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- HY-B0223S
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Albendazole-d3 is the deuterium labeled Albendazole, which is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations[1].
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- HY-10448S1
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Capsaicin-d3 is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].
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- HY-10065S1
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Axitinib-d3 (AG-013736-d3) is deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively[1].
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- HY-B0623AS2
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Ropinirole-d3 (hydrochloride) is the deuterium labeled Ropinirole hydrochloride[1]. Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[2][3].
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- HY-B0559S
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Nabumetone-d3 is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.
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- HY-B0827S
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Dinotefuran-d3 is the deuterium labeled Dinotefuran[1]. Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors[2].
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- HY-123230S1
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Trifloxystrobin-d3 is the deuterium labeled DL-Valine[1].
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- HY-A0093S1
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Mexiletine-d3 (hydrochloride) is deuterium labeled Mexiletine (hydrochloride). Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker[1][2].
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- HY-121046S
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Flunixin-d3 is the deuterium labeled Flunixin. Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity[1][2].
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- HY-13904S
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Flumatinib-d3 is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1].
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- HY-115364S
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Parbendazole-d3 is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.
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- HY-W757743
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Acalabrutinib-d3 (ACP-196-d3) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).
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- HY-B0623S1
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Ropinirole-d3 (SKF 101468-d3) is deuterium labeled Ropinirole. Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease .
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- HY-W006398S
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Pivalate-d3 (sodium) is the deuterium labeled Sodium pivalate[1].
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- HY-B0452S1
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Ritodrine-d3 (hydrochloride) is the deuterium labeled Ritodrine (hydrochloride). Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.
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- HY-101566S
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Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity .
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- HY-14957S
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Ozenoxacin-d3 is the deuterium-labeled Ozenoxacin (HY-14957). Ozenoxacin-d3 is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.
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- HY-70037S
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Cinacalcet-d3 is the deuterium labeled Cinacalcet. Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
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- HY-B0008S
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Sulindac-d3 is deuterium labeled Sulindac. Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.
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- HY-W754911
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Avapritinib-d3 (BLU-285-d3) is deuterium labeled Avapritinib. Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 .
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- HY-133771AS
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Nordoxepin-d3 (hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride (HY-B0725), which is an orally active tricyclic antidepressant[1].
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- HY-17395AS1
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Terbinafine-d3 (TDT 067-d3) is deuterium labeled Terbinafine. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-10208S2
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Pazopanib-d3 (GW786034-d3) is deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively .
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- HY-121246S
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Fluorofenidone-d3 is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].
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- HY-Y0958S
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Methoxyamine-d3 (O-Methylhydroxylamine-d3) hydrochloride is the deuterium labeled Methoxyamine hydrochloride. Methoxyamine hydrochloride is an orally active and potent base excision repair (BER) inhibitor .
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- HY-B1111S1
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Amitraz-d3 is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.
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- HY-16060S1
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Apalutamide-d3 is the deuterium labeled Apalutamide[1]. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[2].
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- HY-15029S
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(±)-Naproxen-d3 is the deuterium labeled (±)-Naproxen. (±)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID)[1].
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- HY-14398S1
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Celecoxib-d3 is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].
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- HY-90009S
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Tadalafil-d3 is the deuterium labeled Nortadalafil. Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
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- HY-17474S
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Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
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- HY-12643S
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Eprinomectin-d3 (MK-397-d3) is the deuterium-labeled Eprinomectin (HY-12643). Eprinomectin is a type of avermectin. Eprinomectin，as a broad-spectrum fungicide，has insecticidal，insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity .
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- HY-10582S
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Flurbiprofen-d3 is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
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- HY-B1743AS
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3 Publications Verification
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Puromycin-d3 (dihydrochloride) is the deuterium labeled Puromycin dihydrochloride. Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis[1].
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- HY-B0331S1
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Enalapril-d3 (MK-421-d3) is deuterium labeled Enalapril. Enalapril (MK-421) is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research .
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- HY-B0361S
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Aspartame-d3 is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
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- HY-14289S
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Cimetidine-d3 is the deuterium labeled Cimetidine. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is an inverse agonist. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].
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- HY-B0561S1
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Spironolactone-d3 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].
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- HY-14779S3
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Riociguat-d3 (BAY 632521-d3) is deuterium labeled Riociguat. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
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- HY-13626S
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Spisulosine-d3 (ES-285-d3) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .
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- HY-B0451AS4
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Dopamine-d3 (hydrochloride) is the deuterium labeled Dopamine hydrochloride (ASL279)-[1].
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- HY-14283S1
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Luliconazole-d3 (NND 502-d3) is deuterium labeled Luliconazole. Luliconazole (NND 502)?is a topical antifungal imidazole antibiotic with broad-spectrum and potent antifungal activity. Luliconazole can be used for the research of skin infection, including?dermatophytosis, tinea corporis, tinea pedis?et al .
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- HY-B0368S
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Captopril-d3 is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM[1][2][3].
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- HY-W740028
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Cefditoren-d3 (sodium) (ME 1206-d3) is deuterium labeled Cefditoren (sodium). Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections .
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- HY-W747682
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Cilnidipine-d3 (FRC-8653-d3) is the deuterium labeled Cilnidipine-d3 (HY-W747682) .
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- HY-W714177S
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Desisopropylatraton-d3 (Atraton-desisopropyl-d3) is deuterium labeled N2-Ethyl-6-methoxy-1,3,5-triazine-2,4-diamine .
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- HY-17514S1
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Itraconazole-d3 is the deuterium labeled Itraconazole (HY-17514)[1].
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- HY-14956S
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Nemonoxacin-d3 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].
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- HY-B0276S
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Ethionamide-d3 is the deuterium labeled Ethionamide. Ethionamide (2-ethylthioisonicotinamide) is an antibiotic used in the treatment of tuberculosis.
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- HY-14771S
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Imeglimin-d3 (EMD 387008-d3) is deuterium labeled Imeglimin. Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function .
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- HY-B1398S
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Ampyrone-d3 is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy .
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- HY-B0253S
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Piroxicam-d3 is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively [1].
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- HY-N0471S
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L-Hyoscyamine-d3 is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].
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- HY-W713365
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Eltrombopag-d3 (SB-497115-d3) is deuterium labeled Eltrombopag. Eltrombopag (SB-497115) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag can be used for the research of cardiovascular. Eltrombopag also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag can induce apoptosis in hepatocellular carcinomab (HCC) as well .
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- HY-15284S1
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Prasugrel-d3 is the deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[1].
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- HY-10234S
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Saracatinib-d3 (AZD0530-d3) (ZG5129) is the deuterium-labeled analog of Saracatinib (HY-10234). Saracatinib-d3 is an inhibitor of the Src kinase, which can inhibit severe sepsis caused by bacterial or various microbial infections .
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- HY-15025S
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Sildenafil-d3 is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
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- HY-10564S
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Sarpogrelate-d3 (hydrochloride) is the deuterium labeled Sarpogrelate hydrochloride. Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis[1][2][3].
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- HY-17038S2
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Agomelatine-d3 is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].
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- HY-15030S1
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Naproxen-d3 is the deuterium labeled Naproxen. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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- HY-101664S
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Ilaprazole-d3 (IY-81149-d3) is deuterium-labeled Ilaprazole (HY-101664) .
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- HY-N1914S
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Ergothioneine-d3 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
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- HY-114277S2
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Sotorasib-d3 (AMG-510-d3) is deuterium labeled Sotorasib. Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C?mutated locally advanced or metastatic non?small cell lung cancer (NSCLC) .
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- HY-18342S
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Diflunisal-d3 is the deuterium labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
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- HY-B0260S
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Methylprednisolone-d3 is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].
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- HY-10394S
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Linezolid-d3 is a deuterium labeled Linezolid (PNU-100766). Linezolid is a synthetic antibiotic that acts by inhibiting the initiation of bacterial protein synthesis[1].
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- HY-B0497S2
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Niclosamide-d3 (BAY2353-d3) is deuterium labeled Niclosamide. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .
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- HY-15762S
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Valdecoxib-d3 is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain[1][2].
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- HY-B0161ES
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(±)-Duloxetine-d3 (hydrochloride) is deuterium labeled (±)-Duloxetine (hydrochloride). (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder research[1].
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- HY-10528S
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Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn 2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor .
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- HY-W705479
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Pazopanib-d3 (hydrochloride) (GW786034-d3 (hydrochloride)) is deuterium labeled Pazopanib (Hydrochloride). Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
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- HY-14957AS
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Ozenoxacin-d3 (hydrochloride) is the deuterium labeled Ozenoxacin hydrochloride. Ozenoxacin hydrochloride is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections[1][2][3].
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- HY-W012480S
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DL-Tryptophan-d3 is the deuterium labeled DL-Tryptophan. DL-Tryptophan is an endogenous metabolite.
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- HY-B0621S
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Triclabendazole-d3 is the deuterium labeled 4-Methoxybenzylamine[1].
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- HY-10984S1
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Pomalidomide-d3 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors[1][2].
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- HY-N1952S
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Isoeugenol-d3 is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
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- HY-W014612S
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Eugenol acetate-d3 is deuterated labeled Decyl aldehyde (HY-W012570). Decyl aldehyde is a simple ten-carbon aldehyde. Decyl aldehyde is a bacterial luciferase substrate.
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- HY-A0039S
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Eletriptan-d3 is the deuterium labeled Eletriptan hydrobromide. Eletriptan hydrobromide is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively[1][2].
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- HY-16774S
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Vericiguat-d3 (BAY1021189-d3) hydrochloride is a deuterated Vericiguat with tracer functionality. Vericiguat is an orally available stimulator of guanylate cyclase .
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- HY-105182S1
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Xanomeline-d3 (LY-246708-d3) is deuterium labeled Xanomeline. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia .
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- HY-141776S
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Omeprazole sulfide-d3 is the deuterium labeled Omeprazole sulfide. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.
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- HY-108251S
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Methotrexate metabolite-d3 is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1].
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- HY-A0014S1
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Ramelteon-d3 is a deuterium-labelled Ramelteon (HY-A0014).
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- HY-14281S
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Trilostane-d3 is the deuterium-labeled Trilostane (HY-14281). Trilostane-d3 (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane-d3 is a synthetic nonhormonal steroid. Trilostane-d3 can be used for the research of breast cancer and prostate cancer .
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- HY-76200S
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Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].
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- HY-B0334S
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Sulbactam-d3 (CP45899-d3) is deuterium labeled Sulbactam. Sulbactam (CP45899) is a competitive, irreversible beta-lactamase inhibitor. Sulbactam shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .
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- HY-32735S
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Triptolide-d3 is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].
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- HY-105028S
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Tenidap-d3 is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor[3].
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- HY-B0106AS
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Etiracetam-d3 is the deuterium labeled Etiracetam. Etiracetam (UCB 6474) is an acetylcholine agonist and a nootropic drug of the racetam family. Less active than its S-enantiomer Levetiracetam (UCB L059)[1].
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- HY-17034BS
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Medetomidine-d3 (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor[1][2].
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- HY-12515AS
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Nicardipine-d3 (hydrochloride) (YC-93 D3) is the deuterium labeled Nicardipine hydrochloride. Nicardipine hydrochloride is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure[1].
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- HY-B0374S2
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Moxonidine-d3 (BDF5895-d3) is deuterium labeled Moxonidine. Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.
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- HY-10353AS
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Raltegravir-d3 (potassium) is the deuterium labeled Raltegravir potassium. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection[1][2].
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- HY-W015913S1
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Sodium 2-oxopropanoate-d3 is the deuterium labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].
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- HY-17395S
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Terbinafine-d3 (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].
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- HY-W099696S1
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N-caproicacidsodiumsalt-d3 is the deuterium labeled N-caproicacidsodiumsalt[1].
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- HY-Y0626S
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Acetohydrazide-d3 (Ethanehydrazonic acid-d3) is deuterium labeled Acetohydrazide. Acethydrazide is an organic building that undergo catalytic hydrogenation to produce N′-methyl acethydrazide (MAH) .
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- HY-B0113S4
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Omeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria .Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .
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- HY-W007692S
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Acetylpyrazine-d3 is deuterated labeled Linalyl acetate (HY-N6948). Linalyl acetate is the principal components of many plant essential oils with potentially anti-inflammatory activity .
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- HY-W008216S
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HMMNI-d3 (Hydroxy Dimetridazole-d3) is deuterium labeled HMMNI (HY-W008216). HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazol (HY-B1244). Dimetridazole is a nitroimidazole class agent that combats protozoan infections .
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- HY-17502S1
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Simvastatin-d3 is the deuterium labeled Simvastatin[1]. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[2].
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- HY-14539S3
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Clozapine-d3 (HF 1854-d3) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM) .
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- HY-B0504S
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4 Publications Verification
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Creatinine-d3 is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle .
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- HY-B0777S
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Moxidectin-d3 (CL-301423-d3) is deuterium labeled Moxidectin. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk .
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- HY-B0125S
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Ofloxacin-d3 is the deuterium labeled Ofloxacin[1].
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- HY-W759629
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Selpercatinib-d3 (LOXO-292-d3) is deuterium labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity .
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- HY-17373S2
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Posaconazole-d3 (SCH 56592-d3) is deuterium labeled Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
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- HY-B0227S
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Ketoprofen-d3 is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
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- HY-106141S
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Albaconazole-d3 is the deuterium labeled Albaconazole[1].
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- HY-B0656AS1
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Rabeprazole-d3 (sodium)mis the deuterium labeled Rabeprazole sodium. Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].
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- HY-70037AS
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Cinacalcet-d3 (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
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- HY-B0192S2
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Alfuzosin-d3 is deuterium labeled Alfuzosin.
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- HY-17413S1
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Zidovudine- 13C,d3 is the 13C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
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- HY-Y1088S2
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Hydrocinnamic acid-d9 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activitie[2]s.
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- HY-Y1088S3
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Hydrocinnamic acid-d5 is the deuterium labeled Hydrocinnamic acid[1]. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities[2].
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- HY-Y0086S
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3-Pyridinecarboxaldehyde-d4 is the deuterium labeled 3-Pyridinecarboxaldehyde[1].
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- HY-100808S
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D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .
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- HY-158995S1
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3-Epiglycyrrhetinic acid-d3 (3α-Glycyrrhetic acid-d3) is the deuterium-labeled 3-Epiglycyrrhetinic acid. 3-Epiglycyrrhetinic acid is a derivative of glycyrrhetic acid. Glycyrrhetic acid and its derivative are considered to have anti-inflammatory, anti-ulcer, and antiviral activities .
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- HY-W004113S
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3,5-Dichlorophenol-d3 is the deuterium labeled 3,5-Dichlorophenol[1].
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- HY-W185208S
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Chloridazon metabolite B1-d3 (Methyldesphenylchloridazon-d3) is deuterium labeled 5-Amino-4-chloro-2-methyl-2,3-dihydropyridazin-3-one .
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- HY-B0113S2
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Omeprazole metabolite Omeprazole sulfone (methoxy-d3) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
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- HY-66008S
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N-Acetyl mesalazine-d3 is the deuterium labeled N-Acetyl mesalazine[1].
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- HY-W286743S1
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CML-d3 is the deuterium labeled CML.
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- HY-141580S1
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C18 Dihydroceramide-d3-1 (N-octadecaoyl-D-eytho-Dihydosphigosie-d3) is deuterium labeled C18 Dihydroceramide. C18 Dihydroceramide is an ester product .
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- HY-139429S
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(?)-11-Hydroxy-Δ8-THC-d3 ((?)-11-Hydoxy-Δ8-Tetahydocaabiol-d3) is deuterium labeled (?)-11-hydroxy-Δ8-THC .
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- HY-W739949
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Imidaprilat-d3 (6366A-d3) is deuterium labeled Imidaprilate. Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease .
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- HY-N10634S
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D-Glucosyl-β-N-palmitoylsphingosine-d3 (N-ω-Cd3-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine. D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .
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- HY-A0118S
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Naloxegol- 13C,d3 (NKTR-118- 13C,d3) is 13C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .
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- HY-14855S
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Tedizolid- 13C,d3 is the 13C- and deuterium labeled Tedizolid. Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome.
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- HY-B0457S2
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Clomipramine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
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- HY-B1192S
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Estradiol benzoate-d3 is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].
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- HY-113468AS1
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3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease .
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- HY-Y1644S
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3,3-Dimethylacrylic acid-d6 is the deuterium labeled 3,3-Dimethylacrylic acid [1]. 3,3-Dimethylacrylic acid-d6 is an endogenous metabolite .
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- HY-N0304S
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L-DOPA-d6 is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease[1][2][3].
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- HY-W744643
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Butylphthalide-d9 (3-n-Butylphthalide-d9) is deuterium labeled Butylphthalide. Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models .
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- HY-B0652S1
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Etonogestrel-d6 is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs[1]. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs)[2].
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- HY-N0650S3
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L-Serine- 13C3, 15N,d3 is the deuterium, 13C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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- HY-13631AS1
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Exatecan-d3 (DX8951f-d3) mesylate is deuterium-labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL .
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- HY-16508S1
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Ulipristal acetate-d3 (CDB-2914-d3) is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma .
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- HY-W011727S
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Pyridoxal Phosphate-d3 is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .
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- HY-W004702S
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Methyl methanesulfonate-d3 is the deuterium labeled Methyl methanesulfonate[1].
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- HY-N0138S1
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Theobromine-d3 is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.
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- HY-70050CS
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Alosetron-d3 (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.
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- HY-W020678S1
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2-Methylbutanal-d3 is deuterated labeled 2-Methylbutanal.
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- HY-B0321S
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Tropicamide-d3 is the deuterium labeled Tropicamide[1]. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops[2][3].
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- HY-19489S1
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(Rac)-Levomepromazine-d3 (hydrochloride) is a labelled racemic Methotrimeprazine, which is a phenothiazine which has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors[1][2].
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- HY-121883S1
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Lignoceric acid-d3 is the deuterium labeled Lignoceric acid[1]. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[2][3].
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- HY-14946S
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Amifampridine-d3 (3,4-Diaminopyridine-d3) is deuterium labeled Amifampridine. Amifampridine (3,4-Diaminopyridine) is an orally active, potent and cell permeable voltage-gated potassium (Kv) channel blocker (PCB). Amifampridine is efficacy in the reversal of BoNT/A (HY-P79153) intoxication. Amifampridine increases transmitter release from neuromuscular junctions (NMJs). Amifampridine can be used for Lambert-Eaton myasthenic syndrome (LEMS) research .
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- HY-B0175S
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Toltrazuril-d3 is deuterated labeled Toltrazuril. Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.
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- HY-B0241S
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Ipratropium-d3 (bromide) is the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].
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- HY-A0009S
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Galanthamine-d3 (hydrobromide) is deuterium labeled Galanthamine (hydrobromide). Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD)[1][2][3].
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- HY-113037S1
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Farnesyl pyrophosphate-d3 (Farnesyl diphosphate-d3) is deuterium-labeled Farnesyl pyrophosphate (HY-113037) .
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- HY-W010892S
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Scopolamine-d3 (hydrobromide) is the deuterium labeled Scopolamine hydrobromide[1].
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- HY-102015S
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6-Biopterin-d3 (L-Biopterin-d3) is deuterium labeled 6-Biopterin. 6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor .
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- HY-B0157S1
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Ketotifen-d3 (HC 20-511-d3) is deuterium labeled Ketotifen. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .
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- HY-N7057S1
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Nonanoic acid-d3 is the deuterium labeled Nonanoic acid. Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2[1].
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- HY-B0332S
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Menadione-d3 is the deuterium labeled Menadione. Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.
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- HY-15394S1
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(Rac)-Rotigotine-d3 hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
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- HY-136450S
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Triclabendazole sulfoxide-d3 is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
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- HY-B0019S
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Azasetron-d3 (hydrochloride) is the deuterium labeled Azasetron hydrochloride[1].
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- HY-78131BS
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(R)-(-)-Ibuprofen-d3 is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
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- HY-50667S1
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Apixaban-d3 (BMS-562247-01-d3) is the deuterium labeled Apixaban (HY-50667) . Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .
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- HY-122426S1
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1-Bromoundecane-d3 is the deuterium labeled 1-Bromoundecane[1].
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- HY-113346S
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1 Publications Verification
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Tetrahydrodeoxycorticosterone-d3 is the deuterium labeled Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2][3].
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- HY-78131AS
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(S)-(+)-Ibuprofen-d3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].
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- HY-10331S
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Regorafenib-d3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor[1].
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- HY-B0106S1
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Levetiracetam-d3 is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].
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- HY-135035S
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Decanoyl-L-carnitine-d3 ((-)-Decanoylcarnitine-d3) is deuterium labeled Decanoyl-L-carnitine. Decanoyl-L-carnitine has stimulatory effect on the formation of desaturated fatty acid metabolites from both [1- 14C]-22:4 (n-6) and [1- 14C]-22:5 (n-3) .
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- HY-B1053S
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Iotalamic acid-d3 is the deuterium labeled Iotalamic acid[1].
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- HY-113335S
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Trihydroxycholestanoic acid-d3 is the deuterium labeled Trihydroxycholestanoic acid[1].
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- HY-W003972S
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2,6-Dimethoxyphenol-d3 (Syringol-d3) is the deuterium labeled 2,6-Dimethoxyphenol (HY-W003972) . 2,6-Dimethoxyphenol is a phenolic compound that scavenges free radicals and exhibits antioxidant activity. 2,6-Dimethoxyphenol is the substrate for determining laccase activity .
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- HY-N0384S
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Homovanillic acid-d3 is the deuterium labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
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- HY-113466S
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4-Hydroxynonenal-d3 is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].
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- HY-B0204S1
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Pimobendan-d3 (UD-CG115-d3) is deuterium labeled Pimobendan (HY-B0204). Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC50 of 0.32 μM .
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- HY-41417S1
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Octanoic acid-d3 is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.
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- HY-10250S1
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Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .
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- HY-13693S
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Mometasone furoate-d3 is a deuterium labeled Mometasone furoate. Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity[1].
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- HY-W017077S
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4-Methylbiphenyl-d3 (4-Phenyltoluene-d3) is the deuterium labeled 4-Methylbiphenyl (HY-W017077). 4-Methylbiphenyl is an endogenous metabolite .
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- HY-B0740S
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Cyclobenzaprine-d3 (hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.
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- HY-B1832S
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Prednisone acetate-d3 is the deuterium labeled Prednisone acetate. Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties[1].
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- HY-B0311S1
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Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .
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- HY-N8253S
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Quercetin 4'-Glucoside-d3 (Spiraeoside-d3) is deuterium labeled Spiraeoside. Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .
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- HY-W042416S2
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N,N-Dimethylacetamide-d3 is the deuterium labeled N,N-Dimethylacetamide[1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent[2].
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- HY-N6703S
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ar-Turmerone-d3 is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .
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- HY-W004260S2
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Arachidic acid-d3) is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].
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- HY-12530S1
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Velpatasvir-d3 (GS-5816-d3) is deuterium labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
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- HY-W654210
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Glycopyrrolate-d3 (bromide) is deuterium labeled Glycopyrrolate. Glycopyrrolate (Glycopyrronium bromide), a quaternary ammonium derivative, is a muscarinic receptor antagonist. Glycopyrrolate has bronchoprotective effect and produces a beneficial effect on blood pressure. Glycopyrrolate can be used for the research of bronchial diseases .
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- HY-B0192AS
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Alfuzosin-d3 hydrochloride is the deuterium labeled Alfuzosin hydrochloride. Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
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- HY-75054S1
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Abiraterone acetate-d3 (CB7630-d3) is deuterium labeled Abiraterone acetate. Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. Abiraterone acetate is a proagent form of Abiraterone (CB7598) .
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- HY-B0440S
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Tenoxicam-d3 is the deuterium labeled Tenoxicam. Tenoxicam (Ro-12-0068), an antiinflammatory agent with analgesic and antipyretic properties.
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- HY-13704S
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SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].
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- HY-N0367S
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Trans-Anethole-d3 is deuterated labeled α-Terpineol (HY-N5142). α-Terpineol is isolated from Eucalyptus globulus Labill, exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria .
α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption .
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- HY-77995S
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2-Methoxybenzaldehyde-d3 is the deuterium labeled 2-Methoxybenzaldehyde[1]. 2-Methoxybenzaldehyde (o-Anisaldehyde), isolated from cinnamon essential oil (CEO), exists antibacterial and antifungal activity[2].
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- HY-111372S
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Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .
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- HY-B0412S4
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Estriol-d3-1 is the deuterium labeled Estriol.
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- HY-113527S
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TRIA-662-d3 is the deuterium labeled TRIA-662[1]. TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities[2].
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- HY-151931S
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JA-ACC-d3 is deuterium labeled JA-ACC[1].
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- HY-17402S3
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Nisoldipine-d3 is deuterated labeled Nisoldipine (HY-17402). Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.
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- HY-B0311AS
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Carbidopa-d3 (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].
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- HY-W160631S
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2-Ethenylpyrazine-d3 is deuterated labeled 2-Ethyl-5-methylpyrazine.
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- HY-123341S
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9-OxoODE-d3 is the deuterium labeled 9-OxoODE[1].
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- HY-N7046S
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Silybin B-d3 (Silibinin B-d3) is deuterium labeled Silybin B. Silybin B (Silibinin B), a flavonolignan separated from Silybum marianum, has anti-tumor activity. Silybin B is the most potent antifibrillogenic and anti-oligomeric component of silymarin and proposes it as a promising anti Alzheimer’s disease agent candidate .
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- HY-13238S1
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Dolutegravir-d3 is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].
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- HY-B0197AS
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Naratriptan-d3 (hydrochloride) is the deuterium labeled Naratriptan, which is a selective 5-HT1 receptor subtype agonist.
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- HY-W012835S1
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4-Methylanisole-d3 is the deuterium labeled 4-Methylanisole[1]. 4-Methylanisole (4-Methoxytoluene) is food flavoring agent and can be naturally found in Ylang Ylang fragrance oil[2].
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- HY-B0188AS
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Mianserin-d3 (hydrochloride) is the deuterium labeled Mianserin hydrochloride. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
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- HY-66011AS2
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Moxifloxacin-d3 (hydrochloride) is the deuterium labeled Moxifloxacin hydrochloride. Moxifloxacin hydrochloride is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia[1][2][3].
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- HY-B1453S
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L-Carnitine-d3 (hydrochloride) is the deuterium labeled L-Carnitine hydrochloride[1].
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- HY-W013049S3
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Docosanoic acid-d3 (Behenic acid-d3) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .
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- HY-15025S2
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Sildenafil-d3-1 (UK-92480-d3-1) is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
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- HY-Y0139S
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3-Aminopropan-1-ol-d6 is the deuterium labeled 3-Aminopropan-1-ol[1].
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- HY-14602S
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Tramiprosate-d6 is the deuterium labeled Tramiprosate. Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].
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- HY-N0210S8
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D-Galactose-d-3 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-B0673S1
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Deupirfenidone-d3-d3 is the deuterium labeled Pirfenidone (HY-B0673)[1].
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- HY-13318S1
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Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC50=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections .
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- HY-W707416S
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N-(2,6-Dimethylphenyl)-N-(2-(methoxy-d3)acetyl)alanine (N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)-DL-alanine-d3) is deuterium labeled N-(2,6-Dimethylphenyl)-N-(2-methoxyacetyl)alanine .
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- HY-66008S1
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N-Acetyl mesalazine-d3-1 is deuterium labeled 5-acetamido-2-hydroxybenzoic acid.
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- HY-100427S
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Imazamox- 13C,d3 is the 13C- and deuterium labeled Imazamox. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death[1][2].
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- HY-40354S2
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Tofacitinib- 13C,d3 (Tasocitinib- 13C,d3) is 13C labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
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- HY-10219S1
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Rapamycin- 13C,d3 (Sirolimus- 13C,d3; AY-22989- 13C,d3) is the 13C and deuterium labeled Rapamycin (HY-10219) .Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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- HY-90001S1
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Ritonavir- 13C,d3 is the 13C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
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- HY-165662S
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Pranoprofen- 13C-d3 (Pyaopofe- 13C-d3) is 13C and deuterium labeled Pranoprofen .
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- HY-121309S1
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Doxorubicinone- 13C,d3 (Adriamycin aglycone- 13C,d3) is 13C labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
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- HY-17034AS
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Dexmedetomidine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].
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- HY-15772S1
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Osimertinib- 13C,d3 is the deuterium and 13C labeled Osimertinib. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively.
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- HY-W014423S7
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L-Histidine-d3 (hydrochloride hydrate)eis the deuterium labeled L-Histidine (hydrochloride hydrate). L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
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- HY-138573S
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N-Acetyl Adamantamine-d3 is the deuterium labeled N-Acetyl Adamantamine[1].
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- HY-A0023AS1
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Alogliptin-d3 is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes[1][2][3].
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- HY-14956S1
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Nemonoxacin-d3-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].
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- HY-170013S
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N-Pyrrolidino Metonitazene-d3 (citrate) (Metoitazepye-d3) is deuterium labeled N-Pyrrolidino Metonitazene (citrate) .
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- HY-90009BS
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cis-Tadalafil-d3 is the deuterium labeled cis-Tadalafil[1].
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- HY-W012982S
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3-Amino-2-oxazolidinone-d4 is a deuterium labeled 3-Amino-2-oxazolidinone. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as an indicator of furazolidone residues[1][2].
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- HY-113136S
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1-Methylguanosine-d3 is deuterium labeled 1-Methylguanosine (HY-113136). 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker .
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- HY-153939S
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Idasanutlin-d3-1 (RG7388-d3-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of MDM2/p53. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia .
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- HY-34439S1
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2,5-Dimethylpyrazine-d3 is deuterated labeled γ-Terpinene (HY-W020183). γ-Terpinene, a monoterpene, is an orally active antioxidant compound which can scavenge radicals directly. γ-Terpinene has potent antinociception activity .
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- HY-17490S
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Oxaceprol-d3 (N-Acetyl-L-hydroxyproline-d3) is deuterium labeled Oxaceprol. Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis .
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- HY-119695AS2
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Simvastatin acid-d3 (Tenivastatin-d3) ammonium is deuterium-labeled Simvastatin acid (ammonium) (HY-119695A) .
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- HY-17504AS
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Rosuvastatin-d3 is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].
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- HY-141582S
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Ceramide 3-d3 (N-Stearoyl phytosphingosine-d3) is deuterium labeled Ceramide 3. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation .
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- HY-10201S4
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Sorafenib-d3 (Donafenib) tosylate is the 13C- and deuterium labeled Sorafenib. Sorafenib-d3tosylate is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib-d3tosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib-d3tosylate induces autophagy and apoptosis. Sorafenib-d3tosylate has anti-tumor activity. Sorafenib is a ferroptosis activator .
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- HY-17360S
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Tiotropium-d3 (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
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- HY-113139S
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1-Methylinosine-d3 is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA[1].
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- HY-W754135
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Indoxacarb-d3 ((S)-DPX-JW062-d3) is the deuterium labeled Indoxacarb .
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- HY-I0637S
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Isovanillin-d3 is the deuterium labeled Isovanillin[1]. Isovanillin is an aldehyde oxidase inhibitor[2]. Antispasmodic activities[3]. Antidiarrheal activities[4].
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- HY-113371S
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2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
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- HY-14781S3
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Levomefolic acid-d3 (L-5-MTHF-d3) is deuterium labeled Levomefolic acid. Levomefolic acid (L-5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .
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- HY-B0113S1
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Omeprazole-d3-1 is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].
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- HY-B0561S2
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Spironolactone-d3-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].
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- HY-10201S
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Sorafenib-d3 (Donafenib), a deuterated compound of Sorafenib, is the first deuterium-generation tumor suppressor small molecule. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively .
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- HY-117580S
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16α-Hydroxyprednisolone-d3 is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes[1][2].
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- HY-W097453S1
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6-(Methylthio)purine3 is the deuterium labeled 6-(Methylthio)purine[1].
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- HY-W100443S
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Trimethyl(p-tolyl)silane-d3 (Trimethylptolylsilane-d3) is the deuterium labeled Trimethyl(p-tolyl)silane (HY-W440454) .
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- HY-14281S2
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Trilostane-d3-1 (Win 24540-d3-1) is deuterium-labeled Trilostane (HY-14281) .
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- HY-B0740S3
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Cyclobenzaprine-d3-1 hydrochloride (MK130-d3-1 hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride (HY-B0740). Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Additionally, Cyclobenzaprine hydrochloride has antiprotozoal activity. Additionally, Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases
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- HY-125446S
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2-Hydroxymethyl olanzapine-d3 (LY-290411-d3) is a deuterium labeled 2-Hydroxymethyl olanzapine. 2-Hydroxymethyl olanzapine is a metabolite of Olanzapine. .
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- HY-108263S
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3-Hydroxy Midostaurin-d5 is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].
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- HY-B1786S
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Sulindac sulfide-d3 is deuterium labeled Sulindac sulfide. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
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- HY-B0197S
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Naratriptan-d3 is the deuterium labeled Naratriptan[1]. Naratriptan is a selective 5-HT1 receptor subtype agonist[2].
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- HY-W016481S
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4-Methoxybenzyl acetate-d3 is deuterated labeled cis-3-Hexenyl Acetate.
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- HY-W015778S
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2-Methoxy-5-methylphenol-d3 is deuterated labeled 2,3-Diethyl-5-methylpyrazine.
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- HY-B1433S
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Perindoprilat-d3 disodium is deuterated labeled Perindoprilat (HY-B1433). Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research .
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- HY-137989S
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Voriconazole N-oxide-d3 (Voriconazole oxynitride-d3) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB) .
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- HY-10284S3
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Linagliptin-d3-1 (BI 1356-d3-1) is the deuterium labeled Linagliptin (HY-10284). Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM .
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-
- HY-W102356S
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Phenethyl acetate-d3 is the deuterium labeled Phenethyl acetate[1].
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-
- HY-12142S
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rac-Vofopitant-d3 (rac-GR 205171-d3) is the deuterium labeled Vofopitant (HY-12142) . Vofopitant is potent tachykinin NK1 receptor antagonist, with pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively .
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- HY-B1565S
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UV Absorber 326-d3 (Bumetrizole-d3-1) is deuterium labeled UV Absorber 326 .
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- HY-B0075S1
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Melatonin-d3 is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .
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- HY-W007355S1
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Skatole-d8 is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].
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- HY-N0230S2
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β-Alanine-d4 is the deuterium labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
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- HY-32349S
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Ercalcidiol-d3 is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status .
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- HY-32351S
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Calcifediol-d3 is a deuterium labeled Calcifediol. Calcifediol, is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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- HY-10002S1
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Calcitriol-d3 is the deuterium labeled Calcitriol[1]. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist[2][3][4][5].
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- HY-B0495S1
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Lamotrigine- 13C,d3 is the 13C- and deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].
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- HY-13683S1
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Mifepristone- 13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-15321S1
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Etoricoxib- 13C,d3 is the 13C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
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- HY-10241S
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Simeprevir- 13C,d3 is the 13C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].
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- HY-N0650S9
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L-Serine- 15N,d3 is the deuterium and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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- HY-18569S2
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3-Indoleacetic acid-2,2-d2 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
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- HY-B0002BS2
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Ondansetron- 13C,d3 is the 13C- and deuterium labeled Ondansetron[1].
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- HY-10999S2
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Trametinib- 13C,d3 is the 13C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].
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- HY-B0389S18
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D-Glucose- 13C3-1 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-B0389S9
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D-Glucose- 13C3-2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-N0098S
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Vanillin- 13C,d3 is the 13C and deuterium labeled Vanillin[1]. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine[2][3].
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- HY-15236S
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PSI-6206- 13C,d3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
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- HY-123489S
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3α,21-Dihydroxy-5α-pregnan-20-one-d3 is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
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- HY-Y1313S
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3-Nitrobenzoic acid-d4 is the deuterium labeled 3-Nitrobenzoic acid[1].
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- HY-19733S
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Lumateperone- 13C,d3 (ITI-007- 13C,d3) tosylate is 13C and deuterium labeled Lumateperone (tosylate). Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia .
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- HY-14153AS
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Tegaserod- 13C,d3 (maleate) is the 13C- and deuterium labeled Tegaserod (maleate). Tegaserod maleate is a selective 5-HT4 receptor partial agonist and a 5-HT2B receptor antagonist. Tegaserod maleate exhibits a promotile effect throughout the gastrointestinal (GI) tract[1][2][5].
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- HY-B0957S
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Erythromycin ethylsuccinate- 13C,d3 is the 13C- and deuterium labeled Erythromycin Ethylsuccinate. Erythromycin Ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin Ethylsuccinate has antiviral activity against HIV-1.
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- HY-B0471S1
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Phenylephrine-2,4,6-d3 (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
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- HY-15463S3
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Imatinib- 13C,d3 (STI571- 13C,d3) is 13C labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and MERS-CoV .
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- HY-13629S1
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Etoposide- 13C,d3 is the 13C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy[1].
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- HY-10163S3
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Dabigatran- 13C,d3 is the 13C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].
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- HY-15005S
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Sofosbuvir- 13C,d3 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
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- HY-G0007S1
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Omeprazole metabolite Omeprazole sulfone- 13C,d3 is the deuterium and 13C labeled Omeprazole metabolite Omeprazole sulfone[1].
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- HY-125818S5
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Cytidine-5'-triphosphate- 15N3,d14 (Cytidine triphosphate- 15N3,d14 dilithium; 5'-CTP- 15N3,d14) dilithium is deuterium and 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
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- HY-101400S1
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Deoxycytidine triphosphate- 15N3,d14 (dCTP- 15N3,d14 dilithium; 2′-Deoxycytidine-5′-triphosphate- 15N3,d14) dilithium is deuterium and 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
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- HY-113018S
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Ibuprofen acyl-β-D-glucuronide-d3 is the deuterium labeled Ibuprofen acyl-β-D-glucuronide[1].
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- HY-W357141S
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MeSA 2-O-b-D-glucoside-d3 is the deuterium labeled MeSA 2-O-b-D-glucoside[1].
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- HY-W015084AS
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(E)-β-Ionone-d3 (β-Lonone-d3) is deuterium-labeled (E)-β-Ionone (HY-W015084A) .
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- HY-17453S
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Salmeterol-d3 (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].
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- HY-165703S
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Prothioconazole-S-methyl-d3 (Prothioconazole-M01-d3) is deuterium labeled Prothioconazole-S-methyl .
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- HY-Y0678S
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1,3,5-Trimethoxybenzene-d3 (Trimethyl phloroglucinol-d3) is the deuterium labeled 1,3,5-Trimethoxybenzene (HY-Y0678). 1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor .
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- HY-101411S
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4-Acetamidobutanoic acid-d3 is the deuterated analog of 4-Acetamidobutanoic acid (HY-101411). 4-Acetamidobutanoic acid (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities .
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- HY-W012499S
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N-Acetyl-L-methionine-d3 is the deuterium labeled N-Acetyl-L-methionine. N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development[1].
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- HY-108229S
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6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit .
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- HY-100642S
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3-O-Methyltolcapone-d7 is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].
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- HY-12769S2
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Mebeverine acid-d3 (Mebeverine metabolite Mebeverine acid-d3) is deuterium labeled Mebeverine acid. Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine. Mebeverine is an antispasmodic agent. Mebeverine acid is a valuable marker of oral exposure to Mebeverine .
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- HY-W015912S
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2-Acetylfuran-d3 is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na +/K +-ATPase whereas in microsomes, both Na +/K +-ATPase and Mg 2+-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .
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- HY-B0712S
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Ceftriaxone-d3 (disodium) is the deuterium labeled Ceftriaxone. Ceftriaxone is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics[1][2].
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- HY-N0384S4
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Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite associated with aromatic amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and adiponectin reductase deficiency .
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- HY-N0229S12
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L-Alanine-d3 is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
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- HY-W654228
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5-Hydroxymethyl-2'-deoxycytidine-d3 is the deuterium labeled 5-Hydroxymethyl-2'-deoxycytidine .
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- HY-W027544S
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MCA-d3 (7-Methoxycoumarin-4-acetic acid3) is the deuterium labeled MCA (HY-W027544) . MCA is a Coumarin (HY-N0709) derivative. MCA quantitates platelet-activating factor (PAF) by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
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- HY-Y0085S
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NSC 190686-d3 is the deuterium labeled NSC 190686[1].
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- HY-165690
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N,N-Dimethylaminosulfonic acid-d3 (Dimethylsulfamic acid-d3) is deuterium labeled N,N-Dimethylaminosulfonic acid .
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- HY-12770S1
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Mebeverine alcohol-d3 (Mebeverine metabolite Mebeverine alcohol-d3) is deuterium labeled Mebeverine alcohol.
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- HY-W017374S1
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4-Ethyl-2-methoxyphenol-d3 is deuterated labeled 2-Methoxy-3-methylpyrazine.
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- HY-B1244S
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1 Publications Verification
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Dimetridazole-d3 is a deuterium labeled Dimetridazole. Dmetridazole, a nitroimidazole-based antibiotic, combats protozoan infections[1].
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- HY-N2362S2
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DL-Alanine-d3 is the deuterium labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6].
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- HY-W017140S
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2-Sec-butyl-3-methoxypyrazine-d3 is deuterated labeled cis-?Jasmone (HY-N7058). Cis-Jasmone is a plant-derived natural product. Cis-Jasmone is constitutively released by many flowers and sometimes by leaves as an attractant for pollinators or as a chemical cue for host location by insect flower herbivores. Cis-Jasmone treatment of crop plants not only induces direct defense against herbivores, but also induces indirect defense by releasing VOCs that attract natural enemies .
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- HY-W740027
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5-Methyl-2'-deoxycytidine-d3 is the deuterium labeled Methyl-2'-deoxycytidine .
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- HY-76547S2
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p-Toluic acid-d3 is the deuterium labeled p-Toluic acid[1]. p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
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- HY-W041300S
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p-Tolylpinacolboronate-d3 (p-Tolylboronic acid pinacol ester-d3) is the deuterium labeled 4,4,5,5-Tetramethyl-2-(p-tolyl)-1,3,2-dioxaborolane (HY-N0350) .
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- HY-W017554S
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1-Chloro-2-methoxybenzene-d3 is the deuterium labeled 1-Chloro-2-methoxybenzene[1].
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- HY-135910S
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3,4-Dehydro Cilostazol-d11 is deuterated labeled 3,4-Dehydro Cilostazol (HY-135910). 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study .
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- HY-W016099S
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3-Methyl-2-quinoxalinecarboxylic acid-d4 is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].
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- HY-34487S3
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1,3-Dimethoxybenzene-d3 (Resorcinol dimethyl ether-d3) is the deuterium labeled 1,3-Dimethoxybenzene (HY-34487). 1,3-Dimethoxybenzene belongs to the class of organic compounds known as dimethoxybenzenes. 1,3-Dimethoxybenzene is an intermediate in synthesis of organic compounds .
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- HY-100642S1
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3-O-Methyltolcapone-d4 is the deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].
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- HY-N0060BS
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(E)-Ferulic acid-d3 is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
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- HY-66011AS3
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Moxifloxacin-d3-1 hydrochloride (BAY 12-8039-d3-1) is a deuterium labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia .
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- HY-Y0957S
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2,5-Difluorobenzoic acid-d3 is the deuterium labeled 2,5-Difluorobenzoic acid[1].
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- HY-B1659S
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Glycerol- 13C3,d8 is the deuterium and 13C labeled Glycerol[1].
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- HY-W009162S3
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Cytidine 5′-monophosphate- 15N3,d12 (5'-Cytidylic acid- 15N3,d12 dilithium; 5'-CMP- 15N3,d12) dilithium is deuterium and 15N labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
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- HY-121259S
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Doxorubicinol- 13C,d3 (TFA) is the deuterium and 13C labeled Doxorubicinol TFA[1].
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- HY-10158S1
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Bosutinib- 13C,d3 (SKI-606- 13C,d3) is 13C labeled Bosutinib. Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively .
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- HY-17410S2
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Iloperidone- 13C,d3 (HP 873- 13C,d3) is 13C labeled Iloperidone. Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .
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- HY-G0020S1
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Nicotine N-β-D-glucuronide-d3 (Nicotine N-glucuronide-d3) is a deuterium labeled compound.
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- HY-32350S1
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Ercalcitriol-d3 is the deuterium labeled Ercalcitriol. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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- HY-W102278S
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Tinuvin-327-d3 (2,4-Di-tert-Butyl-6-(5-chloro-2H-benzotriazol-2-yl)phenol-d3 (UV-327-d3)) is deuterium labeled 2,4-Di-tert-butyl-6-(5-chloro-2H-benzo[d][1,2,3]triazol-2-yl)phenol .
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- HY-Y1169S2
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Fmoc-Asp(OtBu)-OH-d3 (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate-d3) is deuterium labeled Fmoc-Asp(OtBu)-OH. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
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-
- HY-W042164S
-
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N,4-Dimethylaniline-d3 (N-Methyl-p-toluidine-d3) is the deuterium labeled N,4-Dimethylaniline.
|
-
- HY-90009BS2
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cis-ent-Tadalafil-d3 is the deuterium labeled cis-ent-Tadalafil[1].
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-
- HY-114524S
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(E)-4-Oxo-2-nonenal-d3 is the deuterium labeled (E)-4-Oxo-2-nonenal[1].
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-
- HY-W086988S
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5-Methyl-1H-benzotriazole-d6 (5-Methylbenzotriazole-d6) is the deuterium labeled 5-Methyl-1H-benzotriazole (HY-W086988). 5-Methyl-1H-benzotriazole is a biological material or organic compound that can be used in life science research .
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-
- HY-158995S
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3-Epiglycyrrhetinic acid-d2 (3α-Glycyrrhetic acid-d2) is the deuterium-labeled 3-Epiglycyrrhetinic acid. 3-Epiglycyrrhetinic acid is a derivative of glycyrrhetic acid. Glycyrrhetic acid and its derivative are considered to have anti-inflammatory, anti-ulcer, and antiviral activities .
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-
- HY-W343292S1
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2-Methylbutyl acetate-d3 is deuterated labeled 2-Methylbutyl acetate.
|
-
- HY-107494S2
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4-Oxoretinoic acid-d3 is the deuterium labeled 4-Oxoretinoic acid[1].
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-
- HY-12515CS1
-
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(R)-Nicardipine-d3 is the deuterium labeled R-Nicardipine (HY-12515C)[1].
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-
- HY-W016152S
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1-Bromo-3-methoxybenzene-d3 is the deuterium labeled 1-Bromo-3-methoxybenzene. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
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-
- HY-169892S
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4-Hydroxy Nonenal Glutathione-d3 (4-HNE-GSH-d3) is deuterium labeled 4-Hydroxy Nonenal Glutathione .
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-
- HY-W040233S
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Sodium (S)-2-hydroxypropanoate-d3 is the deuterium labeled Sodium (S)-2-hydroxypropanoate[1].
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-
- HY-113371AS
-
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2-Methylcitric acid-d3 (Methylcitric acid-d3) trisodium is deuterium-labeled 2-Methylcitric acid (trisodium) (HY-113371A) .
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-
- HY-I0705S
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Ethyl 2-bromopropionate-d3 is the deuterium labeled Ethyl 2-bromopropionate[1].
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-
- HY-U00050S
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(E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
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-
- HY-113441S
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3-Methoxy-4-Hydroxyphenylglycol sulfate-d3 potassium is the deuterium labeled 3-Methoxy-4-Hydroxyphenylglycol sulfate potassium[1].
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-
- HY-137083S
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Trifluoperazine N-glucuronide-d3 is deuterium labeled Trifluoperazine N-Glucuronide. Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation[1].
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- HY-B2227BS1
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Lactate-d3 sodium (60% in water) is the deuterium labeled Lactate sodium (60% in water). Lactate sodium (60% in water) is the product of glycogenolysis and glycolysis. Lactate sodium (60% in water) functions in a variety of biochemical processes .
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-
- HY-W654126
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Cytarabine- 13C3 (Cytosine β-D-arabinofuranoside- 13C3) is 13C labeled Cytarabine .
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-
- HY-16973S
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Fluralaner- 13C2, 15N,d3 is the deuterium, 13C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
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-
- HY-W097453S2
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6-(Methylthio)purine-d3-1 is the deuterium labeled 6-(Methylthio)purine[1].
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-
- HY-W091636S
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3,3'-Azanediyldipropionic acid-d8 is the deuterium labeled 3,3'-Azanediyldipropionic acid[1].
|
-
- HY-W009719S
-
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1-Bromo-2,3-dichlorobenzene-d3 is the deuterium labeled 1-Bromo-2,3-dichlorobenzene[1].
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-
- HY-W010420S
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2,4-Difluoro-1-methylbenzene-d3 is the deuterium labeled 2,4-Difluoro-1-methylbenzene[1].
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-
- HY-B0330S2
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Levofloxacin- 13C,d3 is the 13C- and deuterium labeled Levofloxacin.
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-
- HY-W012689S
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2-Methyl-2-propylpropane-1,3-diol-d3 is the deuterium labeled 2-Methyl-2-propylpropane-1,3-diol[1].
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-
- HY-W011883S
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1,3-Dibromo-5-fluorobenzene-d3 is the deuterium labeled 1,3-Dibromo-5-fluorobenzene[1].
|
-
- HY-W015855S
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2-Methoxy-3-methylpyrazine-d3 is deuterated labeled 2,3-Diethyl-5-methylpyrazine.
|
-
- HY-W099915S
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3-Ethyl-2,5-dimethylpyrazine-d5 is deuterated labeled Isopentyl isobutyrate.
|
-
- HY-N7092S22
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D-Fructose- 13C3 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
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-
- HY-78131S1
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Ibuprofen- 13C,d3 is the 13C- and deuterium labeled Ibuprofen. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively .
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-
- HY-78985S
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Benzene-1,3,5-tricarboxylic acid-d3 is the deuterium labeled Benzene-1,3,5-tricarboxylic acid[1].
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-
- HY-W354610S
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N-(4-Hydroxy-3-methoxybenzyl)stearamide-d3 is the deuterium labeled N-(4-hydroxy-3-methoxybenzyl)stearamide[1].
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-
- HY-B0762S
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Acetyl-L-carnitine-d3 (hydrochloride) is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders[1].
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-
- HY-20386S
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2-Chloro-N,N-dimethylacetamide-d3 is the deuterium labeled 2-Chloro-N,N-dimethylacetamide[1].
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-
- HY-133685S
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N-Hexanoyl-L-Homoserine lactone-d3 (C6-HSL-d3) is deuterium labeled N-Hexanoyl-L-homoserine lactone. N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats .
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-
- HY-W012615S
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4-Methoxy-N-methylaniline-d3 (N-Methyl-4-anisidine-d3) is the deuterium labeled 4-Methoxy-N-methylaniline.
|
-
- HY-W010529S
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2-Methylfuran-3-thiol-d3 is deuterated labeled Decan-2-one.
|
-
- HY-W045058S
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4-Bromo-N-methylaniline-d3 (P-Bromo-N-methylanline-d3) is the deuterium labeled 4-Bromo-N-methylaniline.
|
-
- HY-B0251S1
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Eplerenone- 13C,d3 (Epoxymexrenone- 13C,d3) is 13C labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
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-
- HY-W009981S
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1-Bromo-2,4-difluorobenzene-d3 is the deuterium labeled 1-Bromo-2,4-difluorobenzene[1].
|
-
- HY-B0158S6
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Cytidine- 15N3 is the 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
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-
- HY-117171S
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Proquinazid-(propoxy-d7) (6-Iodo-2-propoxy-d7-3-propyl-4(3H)-quinazolinone) is deuterium labeled Proquinazid .
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-
- HY-B0712S1
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Ceftriaxone- 13C2,d3 triethylammonium salt is 13C and deuterated labeled Ceftriaxone (HY-B0712). Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone can be used in the study of bacterial infections and meningitis .
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-
- HY-B0192S1
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Alfuzosin- 13C,d3 is the 13C- and deuterium labeled Alfuzosin.
|
-
- HY-14854S
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Tecarfarin- 13C,d3 (ATI-5923- 13C,d3) is 13C labeled Tecarfarin. Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X . Tecarfarin has the antithrombotic activity .
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- HY-10159S1
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Nilotinib-13C,d3 is a deuterated labeled Nilotinib . Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
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-
- HY-106827S1
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Trimegestone- 13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .
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-
- HY-114370S
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Selpercatinib- 13C,d3 (LOXO-292- 13C,d3) is 13C labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity .
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-
- HY-147338S
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5-Methylcytidine 5′-triphosphate-d3 trisodium is the deuterium labeled 5-Methylcytidine 5’-triphosphate trisodium (HY-147338A). 5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. 5-Methylcytidine 5′-triphosphate trisodium can apply in replacing unmodified mRNA, resulting in the increase of translational properties and stability, as well as the reduction of innate immune responses in human and other mammalian cells .
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-
- HY-W653977
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Chlortetracycline-13C,d3 hydrochloride (7-Chlorotetracycline-13C,d3 hydrochloride) is the 13C- and deuterium labeled Chlortetracycline hydrochloride (HY-B1327). Chlortetracycline hydrochloride is an orally active, selective antibiotic, that inhibits methanogenic bacteria through inhibition of bacterial protein synthesis. Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, that inhibits binding of aminoacyl-tRNA to ribosomes .
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- HY-16060S2
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Apalutamide- 13C,d3 is the 13C- and deuterium labeled Apalutamide. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].
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- HY-10065S
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Axitinib- 13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50 values of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively .
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-
- HY-12009S
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Pazopanib- 13C,d3 (hydrochloride) is the deuterium and 13C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
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- HY-14655S1
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Sulfasalazine-d3, 15N is 15N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .
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- HY-10888S
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Istradefylline- 13C,d3 is the 13C- and deuterium labeled Istradefylline. Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
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- HY-17034BS1
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Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .
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-
- HY-W012832S
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2-Ethyl-3-methylpyrazine-d3 is deuterated labeled 3-Methylcyclopentane-1,2-dione.
|
-
- HY-B0374AS
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Moxonidine- 13C,d3 hydrochloride is 13C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) hydrochloride is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.
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- HY-10208S1
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Pazopanib- 13C,d3 is the deuterium and 13C labeled Pazopanib[1]. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].
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-
- HY-14369S
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Elagolix- 13C,d3 (sodium) is the 13C- and deuterium labeled Elagolix sodium. Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
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- HY-15651S
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Alvelestat- 13C,d3 (AZD9668- 13C,d3) is 13C-labeled Alvelestat (HY-15651) .
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- HY-16767S1
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Doravirine-13C,d3 (MK-1439-13C,d3) is the deuterium labeled Doravirine (HY-16767). Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively .
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- HY-10284S1
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Linagliptin- 13C,d3 is the 13C- and deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. Linagliptin-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-A0166S
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Cilastatin- 15N,d3 is a 15N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin is an antibacterial adjunct[1][2][3].
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- HY-10353AS1
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Raltegravir- 13C,d3 potassium is 13C labeled Raltegravir potassium (HY-10353A). Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.
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- HY-A0023AS
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Alogliptin- 13C,d3 is the deuterium labeled Alogliptin. Alogliptin is a potent and selective inhibitor of DPP-4.
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- HY-B0165AS
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Pravastatin- 13C,d3 (sodium) is the 13C- and deuterium labeled Pravastatin (sodium). Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
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- HY-B0113S3
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Omeprazole- 13C,d3 is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].
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- HY-B0740S1
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Cyclobenzaprine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Cyclobenzaprine (hydrochloride).
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- HY-10582S2
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Flurbiprofen- 13C,d3 is the 13C- and deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
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- HY-W086901S
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2-Methyl-3-propylpyrazine-d3 is deuterated labeled 2-Benzylideneheptan-1-ol.
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- HY-B0103AS2
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Fluvoxamine- 13C, d3 maleate is 13C and deuterated labeled Fluvoxamine maleate (HY-B0103A). Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
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- HY-B0596S
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Taltirelin- 13C,d3 (TA-0910- 13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca 2+ concentration (Ca 2+ release).
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- HY-15605S
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Encorafenib- 13C,d3 is the 13C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).
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- HY-12530S3
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Velpatasvir- 13C,d3 (GS-5816- 13C,d3) is 13C and deuterium labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
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- HY-17492S1
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Zafirlukast- 13C,d3 is the 13C- and deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
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- HY-B0656AS3
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Rabeprazole- 13C,d3 (sodium) (LY307640- 13C,d3 (sodium)) is 13C labeled Rabeprazole (sodium). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .
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-
- HY-W018728S
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3,5-Dimethylbenzoic acid-d9 is the deuterium labeled 3,5-Dimethylbenzoic acid[1].
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-
- HY-10805S
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Almorexant- 13C,d3 is the 13C- and deuterium labeled Almorexant. Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.
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- HY-15408S
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Trelagliptin-13C,d3 is a deuterated labeled Trelagliptin . Trelagliptin (SYR-472) is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM) .
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-
- HY-111772S
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Elexacaftor- 13C,d3 is the deuterium labeled Elexacaftor (HY-111772)[1].
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-
- HY-18252S
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Avanafil- 13C,d3 is the 13C- and deuterium labeled Avanafil.
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-
- HY-W700793
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2-Methyl-3-(trifluoromethyl)aniline-d3 (3-Trifluoromethyl-2-methylaniline-d3) is deuterium labeled 2-Methyl-3-(trifluoromethyl)aniline. 2-Methyl-3-(trifluoromethyl)aniline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-17396S
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Butenafine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.
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- HY-50904S1
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Nintedanib- 13C,d3 is the 13C- and deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
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- HY-B0621S1
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Triclabendazole- 13C,d3 is the 13C- and deuterium labeled Triclabendazole[1].
|
-
- HY-B0656S1
-
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Rabeprazole-13C,d3 is a deuterated labeled Rabeprazole . Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .
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-
- HY-113050SA
-
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|
2,3-Diphosphoglyceric acid-d3 ammonium (2,3-DPG-d3 ammonium) is the deuterium labeled 2,3-Diphosphoglyceric acid (HY-113050). 2,3-Diphosphoglyceric acid (2,3-DPG) is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2, 3-diphosphoglyceric acid has antiparasitic activity. 2,3-Diphosphoglyceric acid can be used in the study of Alzheimer's disease (AD) .
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-
- HY-B0227S2
-
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|
Ketoprofen- 13C,d3 is the 13C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].
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-
- HY-13955S2
-
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|
Telmisartan- 13C,d3 is the 13C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
|
-
- HY-17016S3
-
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|
|
Oseltamivir- 13C,d3 (phosphate) (GS 4104- 13C,d3 (phosphate)) is 13C labeled Oseltamivir (phosphate). Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
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-
- HY-10121S4
-
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|
Asenapine-d3, 13C (Org 5222-d3, 13C) is deuterium and 13C labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .
|
-
- HY-17506S1
-
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|
|
Azithromycin- 13C,d3 is the deuterium and 13C labeled Azithromycin[1].
|
-
- HY-N0537S12
-
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|
|
Xylose-d-3 is the deuterium labeled Xylose.
|
-
- HY-B0158S5
-
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|
Cytidine- 13C9, 15N3 is the 13C and 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
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-
- HY-A0132S14
-
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|
|
N-Acetyl-D-glucosamine-d3 (N-Acetyl-2-amino-2-deoxy-D-glucose-d3) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .
|
-
- HY-66011AS4
-
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|
|
Moxifloxacin- 13C,d3 hydrochloride (BAY 12-8039- 13C,d3) is 13C and deuterated labeled Moxifloxacin (HY-66011A). Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.
|
-
- HY-W012927S
-
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|
|
4-Hydroxy-5-methylfuran-3(2H)-one-d3 is deuterated labeled 2-Isopropyl-3-methoxypyrazine.
|
-
- HY-W140887S
-
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|
|
2-Methoxy-4-propylphenol-d3 is deuterated labeled Pent-1-en-3-ol.
|
-
- HY-136450S1
-
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|
|
Triclabendazole sulfoxide- 13C,d3 is the 13C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].
|
-
- HY-50667S
-
|
|
|
Apixaban- 13C,d3 is a deuterium and 13C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1].
|
-
- HY-W110726S1
-
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|
1-Octen-3-one-d3 is deuterated labeled 3-Ethyl-2,5-dimethylpyrazine.
|
-
- HY-W014431S
-
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|
|
1-Bromo-3-chloro-5-fluorobenzene-d3 is the deuterium labeled 1-Bromo-3-chloro-5-fluorobenzene[1].
|
-
- HY-W001260S
-
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|
|
3-Fluoro-4-(hydroxymethyl)benzonitrile-d2 is the deuterium labeled 3-Fluoro-4-(hydroxymethyl)benzonitrile (HY-W001260).
|
-
- HY-W142921S
-
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|
|
Allyl methyl disulfide-d3 is deuterated labeled (E)-Oct-2-enal.
|
-
- HY-10250S
-
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|
|
Triciribine phosphate-- 13C,d3 is the deuterium and 13C labeled Triciribine phosphate[1].
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-
- HY-W021008S
-
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|
|
3-Hydroxy-4,5-dimethylfuran-2(5H)-one-d2 is deuterated labeled 4-Ethyl-2-methoxyphenol.
|
-
- HY-W023443S
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|
2-Isopropyl-5-methylpyrazine-d3 is deuterated labeled 5-Butyldihydrofuran-2(3H)-one.
|
-
- HY-B0762S1
-
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|
|
Acetyl-L-carnitine-d3-1 (hydrochloride) is the deuterium labeled Acetyl-L-carnitine hydrochloride. Acetyl-L-carnitine hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine found in the body. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and exibits anti-stress-related psychiatric disorders[1].
|
-
- HY-W017310S
-
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|
|
3-Bromopropane-1,2-diol-d5 is the deuterium labeled 3-Bromopropane-1,2-diol(HY-W017310) .
|
-
- HY-10201S2
-
1 Publications Verification
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|
Sorafenib- 13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].
|
-
- HY-N7092S23
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D-Fructose- 13C3-1 is 13C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.
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-
- HY-W010153S
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3-(Trifluoromethyl)phenol-d4 is the deuterium labeled 3-(Trifluoromethyl)phenol[1].
|
-
- HY-10331S1
-
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|
|
Regorafenib- 13C,d3 is the 13C- and deuterium labeled Regorafenib. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively.
|
-
- HY-Y0659S
-
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|
|
1,2,3,4-Hydroquinoline-d2 (1,2,3,4-Tetrahydroquinoline-d2) is the deuterium labeled 1,2,3,4-Hydroquinoline.
|
-
- HY-W014423S1
-
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|
L-Histidine- 13C6, 15N3,d5 (hydrochloride hydrate) is the deuterium, 13C-, and 15-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-137522S
-
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|
|
Zidovudine O-β-D-glucuronide-d3 (sodium) (3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 (sodium)) is a deuterium labeled Zidovudine O-β-D-glucuronide (sodium) (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .
|
-
- HY-148682S2
-
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|
|
18β-Glycyrrhetyl-3-O-sulfate-d3 is the deuterium labeled 18β-Glycyrrhetyl-3-O-sulfate (HY-148682)[1].
|
-
- HY-W019726S1
-
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|
|
Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine . Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .
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-
- HY-W131180S
-
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|
|
2,3,5,6-Tetrachloroaniline-d3 is the deuterium labeled 2,3,5,6-Tetrachloroaniline[1].
|
-
- HY-A0023AS2
-
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|
|
Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W192474S
-
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|
|
1-(Furan-2-yl)ethane-1-thiol-d3 is deuterated labeled Allyl methyl disulfide.
|
-
- HY-W013948S
-
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|
|
1-(2,4-Dinitrophenyl)-2-propylidenehydrazine-d3 is the deuterium labeled 1-(2,4-Dinitrophenyl)-2-propylidenehydrazine[1].
|
-
- HY-W246043
-
|
|
|
3-Pyridine-2,4,5,6-d4 -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-d4-carboxylic acid, ethyl ester[1].
|
-
- HY-14781S1
-
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|
|
Levomefolic acid- 13C,d3 is the deuterium labeled Levomefolic acid (HY-14781) . Levomefolic acid (5-MTHF) is an orally active, brain-penetrant natural active form of folic acid and is one of the most widely used folic acid food supplements .
|
-
- HY-W343538S
-
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|
|
2-Methyl-3-(methyldisulfanyl)furan-d3 is deuterated labeled 5-Octyldihydrofuran-2(3H)-one.
|
-
- HY-W777599
-
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|
|
(±)-Naproxen- 13C,d3-1 ((Rac)-Naproxen- 13C,d3-1) is 13C and deuterium labeled (±)-Naproxen .
|
-
- HY-W749691
-
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|
|
(S)-Velpatasvir- 13C,d3 ((S)-GS-5816- 13C,d3) is 13C labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.16 μM .
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-
- HY-W259250S
-
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|
|
5-Chloropyridin-3,4,6-d3-2-amine is the deuterium labeled 5-Chloropyridin-2-amine[1].
|
-
- HY-B0640S
-
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|
Epinastine- 13C,d3 (hydrobromide) is the 13C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action[1][2][3][4].
|
-
- HY-W097453S
-
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|
|
6-(Methylthio)purine- 13C,d3 is the 13C labeled 6-(Methylthio)purine.
|
-
- HY-Z1430S
-
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|
|
Paroxetine EP impurity D-d4 (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity).
|
-
- HY-W010319S
-
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|
|
2-Amino-4-methoxy-6-methyl-1,3,5-triazine-d3 (CGA-150829-d3) is deuterium labeled 2-Amino-4-methoxy-6-methyl-1,3,5-triazine .
|
-
- HY-W099116S
-
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|
|
Ethyl 4-(((methyl(phenyl)amino)methylene)amino)benzoate-d3 (Ultraviolet absorbent UV-1-d3) is deuterium labeled Ethyl 4-(((methyl(phenyl)amino)methylene)amino)benzoate .
|
-
- HY-W176660S
-
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|
|
3-Methylbut-2-ene-1-thiol-d6 is deuterated labeled (Ethyldisulfanyl)ethane.
|
-
- HY-124215S1
-
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|
|
Fenchone-d3 is deuterated labeled Benzo[pqr]tetraphen-3-ol (HY-W585890).
|
-
- HY-Z5058S
-
|
|
|
(3R,5S)-Fluvastatin-d7 (sodium) is the deuterium labeled (3R,5S)-Fluvastatin sodium[1].
|
-
- HY-14664CS
-
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|
|
(3S,5R)-Fluvastatin-d6 (sodium) is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].
|
-
- HY-10002S
-
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|
|
Calcitriol- 13C3 is the 13C-labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
|
-
- HY-32350S
-
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|
|
Ercalcitriol- 13C,d3 is the 13C- and deuterium labeled Ercalcitriol. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.
|
-
- HY-N0229S5
-
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|
|
L-Alanine- 13C3, 15N,d4 is the deuterium, 13C-, and 15-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
|
-
- HY-108226S
-
|
|
|
Regorafenib N-oxide and N-desmethyl (M5)-d3 is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).
|
-
- HY-W010555S
-
|
|
|
3-Methylcyclopentane-1,2-dione-d6 is deuterated labeled 5-Ethyl-3-hydroxy-4-methylfuran-2(5H)-one.
|
-
- HY-W701842
-
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|
|
3-Chloro-2-hydroxypropyl-1,1,2,3,3-d5 oleate (1-Oleoyl-3-chloropropanediol-d5) is deuterium labeled 3-Chloro-2-hydroxypropyl-1,1,2,3,3 oleate .
|
-
- HY-131325S
-
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|
|
Simeton-d3 (N2,N4-Diethyl-6-(methoxy-d3)-1,3,5-triazine-2,4-diamine) is deuterium labeled Simeton .
|
-
- HY-W102449S
-
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|
|
4-Acetyl-N-methylaniline-13C,d3 (1-(4-(Methylamino)phenyl)ethanone-13C,d3) is a 13C and deuterated isotope of 4-Acetyl-N-methylaniline. Compounds labeled with stable or radioactive isotopes can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .
|
-
- HY-167592S
-
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|
|
17:0-20:3 PS-d5 (1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d5)-3-phospho- L-serine (sodium)) is deuterium labeled 17:0-20:3 PS .
|
-
- HY-W016749S
-
|
|
|
N-Acetyl-DL-aspartic acid-2,3,3-d3 is the deuterium labeled N-Acetyl-DL-aspartic acid-2,3,3[1].
|
-
- HY-167583S
-
|
|
|
17:0-20:3 PI-d5 (1-heptadecanoyl-2-eicosatrienoyl-sn-glycero(d5)-3-phosphoinositol (ammonium)) is deuterium labeled 17:0-20:3 PI .
|
-
- HY-W722289S
-
|
|
|
(rac)-Metolachlor metabolite CGA 50267-d3 (N-(2-(Ethyl-2,2,2-d3)-6-methylphenyl)-2-aminopropanoic acid) is deuterium labeled (2-Ethyl-6-methylphenyl)alanine .
|
-
- HY-W289054S
-
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|
|
(S)-Metolachlor metabolite CGA 50720-d3 (2-((2-(Ethyl-2,2,2-d3)-6-methylphenyl)amino)-2-oxoacetic acid) is deuterium labeled 2-((2-Ethyl-6-methylphenyl)amino)-2-oxoacetic acid .
|
-
- HY-150661S
-
|
|
|
3-Epi-25-hydroxyvitamin D3- 13C5 is the 13C labeled 3-Epi-25-hydroxyvitamin D3[1].
|
-
- HY-W721117
-
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|
|
N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine-d3 (Methyl N-acetyl-S-(3-hydroxypropyl)-L-cysteinate-d3) is the deuterium labeled N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine.
|
-
- HY-W701859
-
|
|
|
3-Chloro-2-(stearoyloxy)propyl-1,1,2,3,3-d5 oleate (1-Oleoyl-2-Stearoyl-3-chloropropanediol-d5) is deuterium labeled 3-Chloro-2-(stearoyloxy)propyl-1,1,2,3,3 oleate .
|
-
- HY-W714705S
-
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|
|
(S)-Metolachlor metabolite CGA 368208-d3 sodium salt (Sodium 2-((2-(ethyl-2,2,2-d3)-6-methylphenyl)amino)-2-oxoethane-1-sulfonate) is deuterium labeled Sodium 2-((2-ethyl-6-methylphenyl)amino)-2-oxoethane-1-sulfonate .
|
-
- HY-69188S
-
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|
|
3,4-Dihydro-2H-benzo[b][1,4]thiazine-d2 (3,4-Dihydro-2H-1,4-benzothiazine-d2) is the deuterium labeled 3,4-Dihydro-2H-benzo[b][1,4]thiazine.
|
-
- HY-146836S1
-
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|
|
16:0 PI(5)P-d5 (ammonium) is the deuterium labeled 16:0 PI(5)P (ammonium) .
|
-
- HY-W144430S
-
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|
|
2-[3-(Trifluoromethyl)phenoxy]nicotinic acid-d3 (2-[3-(Trifluoromethyl)phenoxy]pyridine-3-carboxylic acid, 3-[(3-Carboxypyridin-2-yl)oxy]benzotrifluoride-d3) is deuterium labeled 2-[3-(Trifluoromethyl)phenoxy]nicotinic acid .
|
-
- HY-131332S1
-
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|
|
N-Desmethyl ulipristal-d3 ((11β)-11-[4-(Methylamino)phenyl]-3,20-dioxo-19-norpregna-4,9-dien-17-yl-d3) acetate is deuterium labeled N-Desmethyl ulipristal acetate ((11β)-11-[4-(Methylamino)phenyl]-3,20-dioxo-19-norpregna-4,9-dien-17-yl) .
|
-
- HY-A0132S9
-
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|
|
N-Acetyl-D-glucosamine- 13C3, 15N is the 13C and 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2].
|
-
- HY-W128255S1
-
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|
|
2-(4,6-Diphenyl-1,3,5-triazin-2-yl)-5-methoxyphenol-d3 (2-(4,6-Diphenyl-1,3,5-triazine-2-yl)-5-methoxy-xyphenol-d3) is deuterium labeled 2-(4,6-Diphenyl-1,3,5-triazin-2-yl)-5-methoxyphenol .
|
-
- HY-W654262
-
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|
|
10α-Methoxy-9,10-dihydrolysergol-d3 is deuterium labeled ((6aR,9R,10aS)-10a-Methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol (Nicergoline Impurity) .
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| Cat. No. |
Product Name |
|
Classification |
-
- HY-17413S
-
|
Azidothymidine-d<sub>3sub>; AZT-d<sub>3sub>; ZDV-d<sub>3sub>
|
|
Azide
|
|
Zidovudine-d3 is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
|
-
- HY-17413S1
-
|
Azidothymidine-13C,d<sub>3sub>; AZT-13C,d<sub>3sub>; ZDV-13C,d<sub>3sub>
|
|
Azide
|
|
Zidovudine- 13C,d3 is the 13C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
|
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![3,4-Dihydro-2H-benzo[b][1,4]thiazine-d2](http://file.medchemexpress.eu/product_pic/hy-69188s.gif)
![2-[3-(Trifluoromethyl)phenoxy]nicotinic acid-d3](http://file.medchemexpress.eu/product_pic/hy-w144430s.gif)
