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G1

" in MedChemExpress (MCE) Product Catalog:

422

Inhibitors & Agonists

14

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7

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45

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60

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56

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15

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13

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10

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107216
    G-1
    20+ Cited Publications

    Estrogen Receptor/ERR Cancer
    G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.
    G-1
  • HY-160580

    Liposome Others
    G1-OC2-K3-E10 is an ionizable lipid, and can be used for delivery of mRNA in lipid nanoparticles (LNPs) [1].
    G1-OC2-K3-E10
  • HY-137449

    G1T48

    Estrogen Receptor/ERR CDK Cancer
    Rintodestrant (G1T48) is an orally active, non-steroidal and selective estrogen receptor degrader. Rintodestrant (G1T48) is also a CDK4/6 inhibitor [1].
    Rintodestrant
  • HY-112272
    Lerociclib
    1 Publications Verification

    G1T38

    CDK Cancer
    Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 1 nM, 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.
    Lerociclib
  • HY-112272A
    Lerociclib dihydrochloride
    1 Publications Verification

    G1T38 dihydrochloride

    CDK Cancer
    Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.
    Lerociclib dihydrochloride
  • HY-101467A
    Trilaciclib hydrochloride
    1 Publications Verification

    G1T28 hydrochloride

    CDK Cancer
    Trilaciclib (G1T28) hydrochloride is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. Trilaciclib hydrochloride can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib hydrochloride attenuates apoptosis and myelosuppression induced by 5FU (HY-90006) chemotherapy [1].
    Trilaciclib hydrochloride
  • HY-101467
    Trilaciclib
    1 Publications Verification

    G1T28

    CDK Cancer
    Trilaciclib (G1T28) is an orally active CDK4/6 inhibitor with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. . Trilaciclib can effectively inhibit tumor cell proliferation and reduce the hematological toxicity caused by chemotherapy. Trilaciclib attenuates apoptosis and myelosuppression induced by 5FU (HY-90006) chemotherapy [1].
    Trilaciclib
  • HY-158455

    FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AA labelled; G1F with bisecting GlcNAc, 2-AA labelled

    Biochemical Assay Reagents Others
    FA2[3]BG1 & FA2[6]BG1 glycan (G1B), 2-AA labelled (FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AA labelled; G1F with bisecting GlcNAc, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
    FA2[3]BG1 & FA2[6]BG1 glycan (G1B), 2-AA labelled
  • HY-158456

    FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AB labelled; G1F with bisecting GlcNAc, 2-AB labelled

    Biochemical Assay Reagents Others
    FA2[3]BG1 & FA2[6]BG1 glycan (G1B), 2-AB labelled (FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AB labelled; G1F with bisecting GlcNAc, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
    FA2[3]BG1 & FA2[6]BG1 glycan (G1B), 2-AB labelled
  • HY-158861

    G1-nPr-C14E

    Liposome Others
    C3-K2-E14 is a multi-ionizable amino-lipid featuring a central tertiary amine with two identical branches and an n-propyl group. Each branch features a propanamide linking to a branched amine, each with two C14 arms and a hydroxyl. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug discovery.
    C3-K2-E14
  • HY-129848

    Others Others
    Cucumarioside G1 is a triterpene glycoside and can be isolated from Cucumaria fraudatrix [1].
    Cucumarioside G1
  • HY-112197
    PKG drug G1
    2 Publications Verification

    PKG Cardiovascular Disease
    PKG agent G1 targets C42 of PKG Iα. PKG agent G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
    PKG drug G1
  • HY-W127501

    Biochemical Assay Reagents Others
    Prostaglandin G1 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Prostaglandin G1
  • HY-N3521

    Deapi-platycoside E

    Others Others
    Platycoside G1, a natural product found in Platycodon grandiflorum, is a triterpenoid saponin. Platycoside G1 has potent antioxidant activities [1].
    Platycoside G1
  • HY-W582827

    Others
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is a highly efficient catalyst with excellent cross-coupling activity. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is widely used in organic synthesis and can be used to promote various reactions to build complex molecular structures. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) has good adaptability to temperature and reaction conditions, which enables it to exhibit excellent catalytic performance in different reaction systems.
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE)
  • HY-158523

    A2[3]G1 & A2[6]G1 N-linked oligosaccharide

    Biochemical Assay Reagents Others
    A2[3]G1 & A2[6]G1 glycan (G1) (A2[3]G1 & A2[6]G1 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
    A2[3]G1 & A2[6]G1 glycan (G1)
  • HY-158520

    A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AA labelled

    Biochemical Assay Reagents Others
    A2[3]G1 & A2[6]G1 glycan (G1), 2-AA labelled (A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
    A2[3]G1 & A2[6]G1 glycan (G1), 2-AA labelled
  • HY-158522

    A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AB labelled

    Biochemical Assay Reagents Others
    A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions [1].
    A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labelled
  • HY-158473

    FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide

    Biochemical Assay Reagents Others
    FA2[3]G1 & FA2[6]G1 glycan (G1F) (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
    FA2[3]G1 & FA2[6]G1 glycan (G1F)
  • HY-158480

    FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, procainamide labelled

    Biochemical Assay Reagents Others
    FA2[3]G1 & FA2[6]G1 glycan (G1F), procainamide labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
    FA2[3]G1 & FA2[6]G1 glycan (G1F), procainamide labelled
  • HY-158479

    FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, APTS labelled

    Biochemical Assay Reagents Others
    FA2[3]G1 & FA2[6]G1 glycan (G1F), APTS labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
    FA2[3]G1 & FA2[6]G1 glycan (G1F), APTS labelled
  • HY-158481

    FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, 2-AA labelled

    Biochemical Assay Reagents Others
    FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AA labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
    FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AA labelled
  • HY-158478

    FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, 2-AB labelled

    Biochemical Assay Reagents Others
    FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AB labelled (FA2[3]G1 & FA2[6]G1 N-linked oligosaccharide, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
    FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AB labelled
  • HY-169047

    PAMAM G1.5 carboxylate sodium

    SARS-CoV Infection
    PAMAM dendrimer G1.5 carboxylate (PAMAM G1.5 carboxylate) sodium is a polyanionic dendrimers comprising the terminal groups sodium carboxylate. PAMAM dendrimer G1.5 carboxylate shows antiviral activity with the MERS‐CoV plaque inhibition assay, with the inhibition rate of 40.5% [1].
    PAMAM dendrimer G1.5 carboxylate sodium
  • HY-115932

    Aurora Kinase Apoptosis Cancer
    Aurora kinase-IN-1 (Compound 9) is a potent inhibitor of aurora kinase. Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-S progressive cyclins, resulting in cell cycle arrest at the G1/S boundary. Aurora kinase-IN-1 also induces apoptosis. Aurora kinase-IN-1 is a lead compound for chemotherapeutic agents [1].
    Aurora kinase-IN-1
  • HY-158457

    N/A

    Biochemical Assay Reagents Others
    A2[3]G1 N-glycan (N/A) is a Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions [1].
    A2[3]G1 N-glycan
  • HY-110111

    DNA/RNA Synthesis Cancer
    T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase [1].
    T2AA
  • HY-118331

    PD 124895; CL-1957E

    Antibiotic Infection Cancer
    Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer [1] .
    Kazusamycin B
  • HY-P99036

    Tie Cardiovascular Disease Inflammation/Immunology Cancer
    Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1 [1].
    Nesvacumab
  • HY-120140
    Ganoderic acid DM
    1 Publications Verification

    Apoptosis PI3K Metabolic Disease Inflammation/Immunology Cancer
    Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis [1] .
    Ganoderic acid DM
  • HY-P99955

    AMG 451; KHK4083

    Orexin Receptor (OX Receptor) Infection Inflammation/Immunology
    Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated, immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD) [1].
    Rocatinlimab
  • HY-P990716

    PD-1/PD-L1 Inflammation/Immunology
    Sabestomig is an anti-PDCD1/HAVCR2 Ig(G1G1-λ2) monoclonal antibody [1].
    Sabestomig
  • HY-158495

    A2 N-linked oligosaccharide, 2-AA labelled

    Biochemical Assay Reagents Others
    A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions [1].
    A2 glycan (G0), 2-AA labelled
  • HY-P990947

    EGFR Inflammation/Immunology
    HY-P990947 is an EGFR/MET-targeting Ig(G1 -κ_G1 -λ2) type human antibody [1].
    Tilatamig
  • HY-P991003

    TNF Receptor Inflammation/Immunology
    HY-P991003 is an TNFRSF17/KLRK1-targeting (G1_L-κ)_(G1-scFvkh_L-κ) type bispecific antibody [1].
    Ingitamig
  • HY-P990021

    Bacterial Others
    Calpurbatug is an immunoglobulin G1 antibody. Calpurbatug has activity with anti-bacterial DNA-binding protein DNABII family and anti-human monoclonal TRL1068 γ1-chain [1].
    Calpurbatug
  • HY-N8432

    Apoptosis Bacterial Fungal Infection Inflammation/Immunology Cancer
    Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis [1] .
    Dipyrithione
  • HY-146227

    Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase [1].
    DNA topoisomerase II inhibitor 1
  • HY-P990953

    CD3 Inflammation/Immunology
    HY-P990953 is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody [1].
    Zubotamig
  • HY-P990020

    c-Kit Others
    Eglatoprutug is an humanized immunoglobulin G1-kappa, anti-c-Kit monoclonal antibody [1].
    Eglatoprutug
  • HY-156376
    Cu(II)-Elesclomol
    1 Publications Verification

    Cuproptosis Apoptosis Topoisomerase Cancer
    Cu(II)-Elesclomol is a Cu 2+ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity [1].
    Cu(II)-Elesclomol
  • HY-169474

    PAMAM G1.0

    Biochemical Assay Reagents Cancer
    Starburst 1st Generation (PAMAM G1.0) is a Polyamidoamine (HY-164657; PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vitro. Starburst 1st Generation conjugated to di-n-dodecylamine and encapsulating 5-Fluorouracil (HY-90006) increase the solubility of 5-Fluorouracil and are cytotoxic to AGS gastric adenocarcinoma cells [1].
    Starburst 1st generation
  • HY-P990047

    GLP Receptor Metabolic Disease
    Maridebart is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody [1].
    Maridebart
  • HY-155552

    Molecular Glues Apoptosis Cancer
    GSPT1 degrader-1 (compound 9q) is a potent degrader of G1 to S phase transition 1 (GSPT1) via ubiquitin-proteasome system, serves as one of Molecular Glues. GSPT1 degrader-1 also induces cell G0/G1 phase arrest and apoptosis [1].
    GSPT1 degrader-1
  • HY-145865

    Apoptosis Cancer
    Antiproliferative against-3 (comp 33) shows a prominent activity against Hela (IC50 = 0.21 µM), A549 (IC50 = 0.39 µM), and MCF-7 (IC50 = 0.33 µM), respectively. Antiproliferative against-3 (comp 33) also dose dependently induces apoptosis by arresting A549 cells at G1 phase [1].
    c-Met/MEK1/Flt-3-IN-1
  • HY-P990048

    CTLA-4 Cancer
    Muzastotug is a humanized immunoglobulin G1-kappa, anti-CTLA4 monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic [1].
    Muzastotug
  • HY-147407

    EGFR Cancer
    Imbotolimod, immunoglobulin G1-kappa, is a humanized monoclonal antibody with anti-ERBB2 and antineoplastic activity. Imbotolimod is a derivative of telratolimod [1].
    Imbotolimod
  • HY-P990080

    CTLA-4 Cancer
    Sovipostobart is an immunoglobulin G1-kappa, anti-CTLA-4 human monoclonal antibody with cleavable prodomain. Sovipostobart is an immunostimulant and antineoplastic [1].
    Sovipostobart
  • HY-P991033

    VEGFR Inflammation/Immunology
    HY-P991033 is an VEGFA/DLL4-targeting G1-scFvlh_L-κ type bispecific antibody [1].
    Tovecimig
  • HY-148522

    FLT3 Cancer
    FLT3-IN-18 is a potent and selective FLT3 inhibitor with an IC50 value of 0.003 μM. FLT3-IN-18 induces apoptosis and cell cycle arrest at G1 phase. FLT3-IN-18 inhibits FLT3 and STAT5 phosphorylation. FLT3-IN-18 has the potential for the research of acute myeloid leukemia (AML) [1].
    FLT3-IN-18

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