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Pathways Recommended:	PROTAC

Results for "

PROTAC molecules

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ligands for Target Protein for PROTAC (7) PROTAC Linkers (805) PROTAC-Linker Conjugates for PAC (1) ADC Cytotoxin (1) ADC Linker (58) Androgen Receptor (5) Apoptosis (27) Aurora Kinase (1) Autophagy (56) Bacterial (1) Biochemical Assay Reagents (1) Btk (3) c-Myc (1) CaMK (1) Caspase (1) CDK (2) Drug Intermediate (2) E1/E2/E3 Enzyme (1) E3 Ligase Ligand-Linker Conjugates (137) EGFR (1) Epigenetic Reader Domain (7) Estrogen Receptor/ERR (3) Ferroptosis (1) Fluorescent Dye (1) Glutathione Peroxidase (1) HSP (1) IRAK (1) Isotope-Labeled Compounds (1) Ligands for E3 Ligase (61) Liposome (1) MAP4K (1) MDM-2/p53 (2) Molecular Glues (2) mTOR (1) NAMPT (1) PD-1/PD-L1 (1) PI3K (1) Progesterone Receptor (1) PROTACs (35) Ras (1) STAT (4) Tau Protein (1) α-synuclein (1)
By Research Areas:	Cancer (1035) Endocrinology (1) Infection (7) Inflammation/Immunology (9) Metabolic Disease (3) Neurological Disease (2)
Click Chemistry:	ADC Synthesis (54) TCO (17) DBCO (99) PROTAC Synthesis (787) Azide (442) BCN (30) Tetrazine (23) Alkynes (227)

1059

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Isotope-Labeled Compounds

824

Click Chemistry

Targets Recommended: PROTAC Linkers PROTAC-Linker Conjugates for PAC Ligands for Target Protein for PROTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010642

Pent-4-yn-1-ol 4-Pentyn-1-ol	PROTAC Linkers	Cancer
Pent-4-yn-1-ol is a PROTAC linker. Pent-4-yn-1-ol can be used to synthesize PROTAC molecules (e.g. RD-23 (HY-168867)) .

HY-151719

Azidoacetic Acid 2-Azidoacetic acid	ADC Linker	Others
Azidoacetic Acid (2-Azidoacetic acid) (compound 92-1) is a click chemistry reagent containing an azide group. Azidoacetic Acid can be used as a small molecule tool for the synthesis of PROTAC . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-155021

PROTAC α-synuclein degrader 5	PROTACs α-synuclein	Neurological Disease
PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders (PROTAC) of α-synuclein aggregates, with an DC₅₀ of 7.51 μM and the highest degradation rate D_max of 89%. PROTAC α-synuclein degrader 5 contains probe molecule sery308 and E3 ligase ligands. PROTAC α-synuclein degrader 5 can be used for neurological disease research .

HY-400147

mPEG45-diol	PROTAC Linkers	Cancer
mPEG45-diol is a PEG derivative containing polyether units. mPEG45-Epoxide is a PROTAC linker can be used to synthesize PROTAC molecules .

HY-172117

Boc-methylglycine-C2-bromine	PROTAC Linkers	Cancer
Boc-methylglycine-C2-bromine is a PROTAC linker.Boc-methylglycine-C2-bromine can be used to synthesize PROTAC molecules like PROTAC SMARCA2 degrader-24 (HY-169275) .

HY-153735

ERK-CLIPTAC	PROTACs	Others
ERK-CLIPTAC is a PROTAC molecule that triggers the degradation of ERK .

HY-D2420

Biotin-PEG5-Mal	PROTAC Linkers	Cancer
Biotin-PEG5-Mal is a PROTAC linker, belonging to the PEG class. It can be used for the synthesis of PROTAC molecules .

HY-168726

Octane-1,8-diamine-Glycolic acid	PROTAC Linkers	Cancer
Octane-1,8-diamine-Glycolic acid is a PROTAC linker that can be used to synthesize PROTAC molecules (HY-168725) for research in the cancer .

HY-159800

6-(4-Azidobutanamido)hexanoic acid	PROTAC Linkers	Others
6-(4-Azidobutanamido) hexanoic acid is a PROTAC Linker that can be used to synthesize the PROTAC molecule NR-11c (HY-159798) .

HY-A0102

AMCA 4-(Aminomethyl)-1-cyclohexanecarboxylic acid	PROTAC Linkers	Cancer
AMCA (4-(Aminomethyl)-1-cyclohexanecarboxylic acid) is a PROTAC linker. AMCA can be used to synthesize the PROTAC molecule YB-3–17 (HY-170405) .

HY-W457950

Thalidomide-5-propargyl	Ligands for E3 Ligase	Cancer
Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design .

HY-130872A

HS-PEG5-CH2CH2NH2 hydrochloride Thiol-PEG5-amine hydrochloride	PROTAC Linkers	Cancer
HS-PEG5-CH2CH2NH2 hydrochloride is a PROTAC linker and belongs to the PEG class. Can be used to synthesize PROTAC molecules.

HY-W250928A

Biotin-PEG-azide (MW 600)	PROTAC Linkers	Cancer
Biotin-PEG-azide (MW 600) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W250928B

Biotin-PEG-azide (MW 1000)	PROTAC Linkers	Cancer
Biotin-PEG-azide (MW 1000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W250928E

Biotin-PEG-azide (MW 5000)	PROTAC Linkers	Cancer
Biotin-PEG-azide (MW 5000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W877989

BWA-522 intermediate-1	Ligands for E3 Ligase	Cancer
BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7 .

HY-W754588

exo-BCN-L-Lysine	PROTAC Linkers	Others
exo-BCN-L-Lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. exo-BCN-L-Lysine contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-W591338B

HO-PEG-CH2COOH (MW 35000)	PROTAC Linkers	Cancer
HO-PEG-CH2COOH (MW 35000) is a *PROTAC* linker belonging to the PEG class. HO-PEG-CH2COOH (MW 35000) can be used to synthesize PROTAC molecule .

HY-47373

Folate-PEG3-C2-acid	PROTAC Linkers	Cancer
Folate-PEG3-C2-acid is the acid fragment of Folate-PEG3-NHS ester (HY-133493), which belongs to the PEG-type PROTAC linker and is used to synthesize PROTAC molecules.

HY-140339

ANB-NOS	PROTAC Linkers	Cancer
ANB-NOS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . ANB-NOS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140346

L-Azidohomoalanine	PROTAC Linkers	Cancer
L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . L-Azidohomoalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140346A

L-Azidohomoalanine hydrochloride 4 Publications Verification	PROTAC Linkers	Cancer
L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-D1295

Pyrene azide 3	PROTAC Linkers	Cancer
Pyrene azide 3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Pyrene azide 3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-146324

PROTAC eEF2K degrader-1	PROTACs CaMK Apoptosis	Cancer
PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting *PROTAC* small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation .

HY-157052

exo-BCN-Fmoc-L-Lysine	PROTAC Linkers	Others
exo-BCN-Fmoc-L-Lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. exo-BCN-Fmoc-L-Lysine contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-141128

Ac4GalNAz	PROTAC Linkers	Cancer
Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Ac4GalNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-134695

5-(Biotinamido)pentylazide	PROTAC Linkers	Cancer
5-Biotinamidopentylazide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . 5-(Biotinamido)pentylazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-138461

Azido-PEG1	PROTAC Linkers	Cancer
Azido-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W584514

Thalidomide-NH-(CH2)2-NH2 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-NH-(CH2)2-NH2 TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules designed to synthesize small PROTAC molecules targeting SHP2 protein.

HY-43614

Propynol Ethoxylate	PROTAC Linkers	Cancer
Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propynol Ethoxylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138749

Biotin alkyne	PROTAC Linkers	Cancer
Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Biotin alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111556

BSJ-03-123 5 Publications Verification	PROTACs CDK	Cancer
BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.

HY-W797383

Phthalimidinoglutarimide-6-piperazine	E3 Ligase Ligand-Linker Conjugates	Cancer
Phthalimidinoglutarimide-6-piperazine is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-161185

Thalidomide-piperidine-O-azetidine-boc	Ligands for E3 Ligase	Cancer
Thalidomide-piperidine-O-azetidine-boc is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-161496

Boc-NHCH2-Ph-Py-NH2	PROTAC Linkers	Cancer
Boc-NHCH2-Ph-Py-NH2 is the linker for PROTAC molecule XYD190 (HY-161494) .

HY-161499

Boc-NHCH2-Ph-pyrimidine-NH2	PROTAC Linkers	Cancer
Boc-NHCH2-Ph-pyrimidine-NH2 is the linker for PROTAC molecule XYD198 (HY-161498) .

HY-141293

Oleic-DBCO	PROTAC Linkers	Cancer
Oleic-DBCO is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Oleic-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-140335

Alkynyl myristic acid 2 Publications Verification	PROTAC Linkers	Cancer
Alkynyl myristic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Alkynyl myristic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-123916

DBCO-Biotin	PROTAC Linkers	Cancer
DBCO-Biotin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . DBCO-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-140455

Azido-PEG10-acid	PROTAC Linkers	Cancer
Azido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG10-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140453

Azido-PEG6-acid	PROTAC Linkers	Cancer
Azido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG6-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140456

Azido-PEG12-acid	PROTAC Linkers	Cancer
Azido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG12-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140457

Azido-PEG24-acid	PROTAC Linkers	Cancer
Azido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG24-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140458

Azido-PEG36-acid	PROTAC Linkers	Cancer
Azido-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG36-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140660

Azide-PEG-alcohol (MW 2000)	PROTAC Linkers	Cancer
Azide-PEG-alcohol (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG-alcohol (MW 2000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140664

Azide-PEG-azide (MW 2000)	PROTAC Linkers	Cancer
Azide-PEG-azide (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG-azide (MW 2000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140665

Azide-PEG-azide (MW 5000)	PROTAC Linkers	Cancer
Azide-PEG-azide (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG-azide (MW 5000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140666

Azide-PEG-azide (MW 10000)	PROTAC Linkers	Cancer
Azide-PEG-azide (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG-azide (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140667

Azide-PEG-azide (MW 20000)	PROTAC Linkers	Cancer
Azide-PEG-azide (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG-azide (MW 20000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140682

m-PEG-azide (MW 2000)	PROTAC Linkers	Cancer
m-PEG-azide (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . m-PEG-azide (MW 2000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name

HY-L151

PROTAC Library

330 compounds

PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy.

MCE supplies a unique collection of 330 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

HY-L128

E3 Ligase Ligand Library

65 compounds

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 65 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L129

Target Protein Ligand Library

56 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 56 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

Cat. No.	Product Name	Type

HY-D2420

Biotin-PEG5-Mal	Fluorescent Dyes/Probes
Biotin-PEG5-Mal is a PROTAC linker, belonging to the PEG class. It can be used for the synthesis of PROTAC molecules .

HY-133376

DBCO-NHCO-PEG12-biotin	Dyes
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DBCO-NHCO-PEG12-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-130768

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid

Fluorescent Dyes/Probes

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker which contains azide, fluorescein and carboxylic acid moieties. N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Chemical Structure

HY-140346AS

L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride

L-Azidohomoalanine-1,2,3,4- ¹³C₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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