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70

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (1) 5-HT Receptor (11) Adenosine Receptor (2) Adrenergic Receptor (7) Akt (15) Aldose Reductase (1) AMPK (2) Amylases (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (18) Antibody-Drug Conjugates (ADCs) (1) Apelin Receptor (APJ) (1) Apoptosis (49) Arrestin (1) Aryl Hydrocarbon Receptor (2) ATP Citrate Lyase (1) Aurora Kinase (2) Autophagy (21) Bacterial (38) Bcl-2 Family (6) Bcr-Abl (3) Beta-secretase (1) Biochemical Assay Reagents (20) Btk (1) c-Kit (1) c-Met/HGFR (1) Calcium Channel (2) Cannabinoid Receptor (2) Carbonic Anhydrase (3) Casein Kinase (1) Caspase (5) Cathepsin (1) CCR (1) CD28 (1) CD38 (1) CDK (6) Checkpoint Kinase (Chk) (1) Cholecystokinin Receptor (1) Cholinesterase (ChE) (3) Complement System (2) Constitutive Androstane Receptor (1) COX (7) CXCR (2) Cytochrome P450 (2) Dengue Virus (1) Dihydrofolate reductase (DHFR) (1) Discoidin Domain Receptor (2) DNA-PK (4) DNA/RNA Synthesis (7) Dopamine Receptor (6) Drug Metabolite (2) E3 Ligase Ligand-Linker Conjugates (1) EAAT (2) EGFR (5) Elastase (1) Endogenous Metabolite (16) Ephrin Receptor (2) Epigenetic Reader Domain (2) Epoxide Hydrolase (1) ERK (6) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (1) FAAH (4) FAK (1) Farnesyl Transferase (1) FGFR (3) Flavivirus (1) FLT3 (4) Fluorescent Dye (6) Formyl Peptide Receptor (FPR) (1) FOXO (1) Fungal (9) Glycosidase (4) Glycosyltransferase (1) GPR4 (1) GSK-3 (2) Guanylate Cyclase (1) HBV (1) HDAC (5) Hedgehog (2) Herbicide (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (3) Histone Acetyltransferase (1) Histone Demethylase (4) Histone Methyltransferase (3) HIV (8) HIV Integrase (1) HMG-CoA Reductase (HMGCR) (9) HSP (48) HSV (1) ICMT (1) IFNAR (2) IGF-1R (2) IKK (3) Imidazoline Receptor (2) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (3) Integrin (1) Interleukin Related (5) Isotope-Labeled Compounds (15) JAK (3) JNK (8) Kallikrein (1) Leukotriene Receptor (1) Ligands for E3 Ligase (2) Ligands for Target Protein for PROTAC (1) Liposome (1) Lipoxygenase (3) LRRK2 (2) mAChR (1) MAGL (2) MAP4K (1) MASTL (1) MCHR1 (GPR24) (3) MDM-2/p53 (3) MEK (2) MicroRNA (1) Microtubule/Tubulin (8) Mitochondrial Metabolism (2) MMP (1) MNK (1) Monoamine Oxidase (3) mTOR (7) nAChR (3) Necroptosis (1) NEKs (2) Neuropeptide FF Receptor (1) Neuropeptide Y Receptor (1) NF-κB (7) NO Synthase (7) NOD-like Receptor (NLR) (3) Opioid Receptor (1) Orexin Receptor (OX Receptor) (1) P-glycoprotein (1) P2X Receptor (1) P2Y Receptor (4) p38 MAPK (8) Parasite (5) PARP (4) PCSK9 (1) PD-1/PD-L1 (2) PDGFR (4) PDK-1 (1) PERK (1) Phosphatase (3) Phosphodiesterase (PDE) (2) Phospholipase (4) Phosphorylase (1) Photosensitizer (1) PI3K (7) Pim (1) PKA (3) PKC (2) PKD (1) Potassium Channel (10) PPAR (2) Progesterone Receptor (3) Prostaglandin Receptor (2) PROTACs (6) Protease Activated Receptor (PAR) (4) Proteasome (2) Pyruvate Kinase (1) Raf (6) Ras (4) Reactive Oxygen Species (4) RET (3) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (16) ROCK (2) ROS Kinase (1) RSV (2) SARS-CoV (3) Ser/Thr Kinase (1) Ser/Thr Protease (1) SHP2 (1) Sirtuin (4) Small Interfering RNA (siRNA) (10) Sodium Channel (1) Src (4) STAT (3) STING (4) Succinate Dehydrogenase (1) Syk (4) Target Protein Ligand-Linker Conjugates (6) TGF-beta/Smad (1) TMV (1) TNF Receptor (4) Toll-like Receptor (TLR) (2) Transmembrane Glycoprotein (1) Trk Receptor (1) TRP Channel (2) TSH Receptor (1) Tyrosinase (6) VEGFR (11) Xanthine Oxidase (3) α-synuclein (1)
By Research Areas:	Cancer (214) Cardiovascular Disease (34) Endocrinology (13) Infection (69) Inflammation/Immunology (88) Metabolic Disease (34) Neurological Disease (63)
Click Chemistry:	Alkynes (4)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (8) Polymers (2) siRNAs (10)

492

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

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Peptides

MCE Kits

Inhibitory Antibodies

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Isotope-Labeled Compounds

Antibodies

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14536A

Methylene blue (purity≥70%) Basic Blue 9 (purity≥70%); CI-52015 (purity≥70%); Methylthioninium chloride (purity≥70%)	Guanylate Cyclase Monoamine Oxidase NO Synthase Microtubule/Tubulin	Infection Neurological Disease Cancer
Methylene blue (purity≥70%) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue (purity≥70%) is a vasopressor and is often used as a dye in several medical procedures. Methylene blue (purity≥70%) through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue (purity≥70%) is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue (purity≥70%) is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-P990264

Anti-Mouse CD70 Antibody (FR70)	Transmembrane Glycoprotein	Others
Anti-Mouse CD70 Antibody (FR70) is a rat-derived IgG2b, κ type antibody inhibitor, targeting to mouse CD70.

HY-150611

EGFR-IN-70	EGFR	Cancer
EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC₅₀ values of 23.6 and 307.5 nM for EGFR ^LR/TM/CS and EGFR ^WT, respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR. EGFR-IN-70 can be used for cancer research .

HY-143400

HSP70-IN-3	HSP Hedgehog	Cancer
HSP70-IN-3 is a potent *HSP70* inhibitor (IC₅₀s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1 .

HY-131960A

Sucrose-epichlorohydrin copolymer 70 Polysucrose 70	Biochemical Assay Reagents	Others
Sucrose-epichlorohydrin copolymer 70 (Polysucrose 70) is a branched polysaccharide polymer with a high molecular weight. Sucrose-epichlorohydrin copolymer 70 is formed by the copolymerization of sucrose and epichlorohydrin, which can be used for cell separation .

HY-149019

Antitumor agent-70	c-Kit Apoptosis	Cancer
Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC₅₀ value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit .

HY-168565

Tubulin polymerization-IN-70	Apoptosis Microtubule/Tubulin Reactive Oxygen Species	Cancer
Tubulin polymerization-IN-70 (compound Q19) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-70 shows antiproliferative activity. Tubulin polymerization-IN-70 target the colchicine binding site of tubulin and inhibited tubulin polymerization. Tubulin polymerization-IN-70 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-70 induces mitochondrial membrane potential decrease and increases the levels of reactive oxygen species (ROS). Tubulin polymerization-IN-70 shows antiangiogenic and anticancer activity .

HY-160223

ssVACV-70mer sodium	STING	Infection Inflammation/Immunology
ssVACV-70mer sodium is a 70 bp single-stranded oligonucleotide containing viral DNA motifs that derive from the vaccinia virus DNA. Unlike its double-stranded counterpart dsVACV 70mer, ssVACV 70mer is not IFN-inducer .

HY-159148

AChE-IN-70	Cholinesterase (ChE)	Others
AChE-IN-70 (compound 4) is a AChE inhibitor. AChE-IN-70 shows larvicidal activity against mosquito larvae (Culex pipiens L.). and can be used for study of mosquito control .

HY-160224

dsVACV-70mer sodium	STING IFNAR	Inflammation/Immunology
dsVACV-70mer sodium is a 70 bp double-stranded oligonucleotide containing viral DNA motifs derived from vaccinia virus DNA. dsVACV-70mer sodium has potently induces IFN-β via a STING-dependent manner .

HY-155712

Antifungal agent 70	Fungal	Infection
Antifungal agent 70 (compound 13) is a dihydroeugenol-imidazole against multi-resistant Candida auris (MIC: 36.4 μM). Antifungal agent 70 shows antifungal activity .

HY-18406

HSP70-IN-4	HSP	Cancer
HSP70-IN-4 (Compound YM-01) is an *Hsp70* inhibitor with an IC₅₀ of 3.2 μM. HSP70-IN-4 is not BBB permeable .

HY-100337

WWL70 2 Publications Verification	MAGL	Neurological Disease
WWL70 is a selective alpha/beta hydrolase domain 6 (ABHD6) inhibitor with an IC₅₀ of 70 nM.

HY-121522

SD-70	Histone Demethylase	Cancer
SD-70 is an inhibitor for histone demethylase JMJD2C and exhibits antitumor efficacy. SD-70 inhibits viability of cancer cells CWR22Rv1 (9% cell survival at 10 μM), PC3 (14% cell survival at 2 μM) and DU145 (26% cell survival at 2 μM) .

HY-P10541

HSP70/DnaK substrate peptide	HSP	Others
HSP70/DnaK substrate peptide is a short peptide that the HSP70/DnaK molecular chaperone can bind and act on. HSP70/DnaK substrate peptide can be used to study the mechanism of action of HSP70/DnaK in molecular chaperone function .

HY-149307

CYCA-117-70	Ligands for E3 Ligase	Others
CYCA-117-70 is a DCAF1 ligand (K_D: 70 μM). CYCA-117-70 is an ideal chemical handles for PROTACs recruiting DCAF1 .

HY-W269867S

Tetratriacontane-d70 ALKANE C34-d₇₀	Isotope-Labeled Compounds	Others
Tetratriacontane-d₇₀ is the deuterium labeled Tetratriacontane[1].

HY-113805

MC70	P-glycoprotein	Cancer
MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC₅₀ of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1 .

HY-147816

Anticancer agent 70	Mitochondrial Metabolism	Cancer
Anticancer agent 70 (Compound 21), an anticancer agent, exhibits remarkable cytotoxic activity against numerous human cancer cell lines. Anticancer agent 70 results in the G0/G1-cell cycle arrest with a concomitant increase in p53 and p21 protein levels. Anticancer agent 70 leads to ATP depletion and disruption of the mitochondrial membrane potential .

HY-163854

HSP70-IN-6	HSP Bcl-2 Family Apoptosis	Cancer
HSP70-IN-6 (Compound JL-15) is an inhibitor of *Hsp70-Bim* protein-protein interaction (PPI) (IC₅₀: 70 nM). HSP70-IN-6 induces apoptosis in chronic myeloid leukemia (CML) cells, with EC₅₀s of 0.43 μM(BV173), 0.88 μM (K562), 0.19 μM (K562-R3) .

HY-P5923

E70K	CXCR	Inflammation/Immunology
E70K is a CXCL8 C-terminal peptide with a substitution of glutamic acid (E) 70 with lysine (K). E70K can reduce neutrophil adhesion and migration during inflammation .

HY-172134

NLRP3-IN-70	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-70 (Compound 5m) is an NLRP3 inflammasome inhibitor with low oral bioavailability. NLRP3-IN-70 can directly bind to the NACHT domain of the NLRP3 protein and block the interaction of NLRP3 and ASC, thus inhibiting ASC oligomerization and NLRP3 inflammasome assembly. NLRP3-IN-70 can be used in the research of sepsis and nonalcoholic steatohepatitis .

HY-124830

SPA70	Others	Cancer
SPA70 is a potent and selective antagonist of human pregnane X receptor (hPXR), with an IC₅₀ of 540 nM (K_i=390 nM). SPA70 can enhance the chemosensitivity of cancer cells .

HY-P1896

Hsp70-derived octapeptide	HSP	Infection Neurological Disease Cancer
Hsp70-derived octapeptide is a conserved octapeptide of the C-terminal end of Hsp70, which physically interacts with tetratricopeptide repeat (TPR) motifs .

HY-W440986S

Distearoylphosphatidylserine-d70 sodium DSPS-d₇₀ sodium	Isotope-Labeled Compounds	Others
Distearoylphosphatidylserine-d70 (sodium) is deuterium labeled (S)-2-amino-2-carboxyethyl ((R)-2,3-bis(stearoyloxy)propyl) phosphate.

HY-138364

YUM70 2 Publications Verification	HSP Apoptosis	Cancer
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC₅₀ of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model .

HY-P3728

Interleukin II (60-70)	Interleukin Related	Inflammation/Immunology
Interleukin II (60-70) is a 60-70 fragment of the cytokine Interleukin II polypeptide .

HY-170944

BAG3/HSP70-IN-1	HSP Apoptosis Caspase	Cancer
BAG3/HSP70-IN-1 (compound 16) is the first-in-class BAG3/HSP70 dual modulator. BAG3/HSP70-IN-1 inhibits HeLa cells with an IC₅₀ of 49.46 μM. BAG3/HSP70-IN-1 induces Apoptosis by activating caspase 3 and caspase 9 levels in HeLa cells. BAG3/HSP70-IN-1 elevates p21 levels while reduces FOXM1 expression in HeLa cells. BAG3/HSP70-IN-1 decreases ATPase activity .

HY-N13173

α-Glucosidase-IN-70	Glycosidase	Metabolic Disease
α-Glucosidase-IN-70 (compound 9) is an α-glucosidase inhibitor (IC₅₀=31.1 μM) isolated from the traditional Chinese herbal medicine Swertia mussotii. α-Glucosidase-IN-70 can be used in the research of diabetes .

HY-144255

Antibacterial agent 70	ROS Kinase	Inflammation/Immunology
Antibacterial agent 70 is a new dihydropyrimidinone imidazole hybrid antibacterial agent, and its < b > MIC < / b > value is 0.5 μg/mL

HY-112624B

Dextran T70 (MW 70,000) Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)	Biochemical Assay Reagents	Others
Dextran T70 (MW 70,000) is a complex carbohydrate polymer consisting of glucose molecules linked by glycosidic bonds. Dextran has excellent solubility in water, making it useful as a viscosity modifier or stabilizer in foods, paints and adhesives. In the biomedical field, dextran is often used as a plasma expander because of its ability to increase blood volume when administered intravenously. It can also be modified to create dextran-based drug delivery systems, such as targeted nanoparticles.

HY-149638

HSP70/SIRT2-IN-2	Sirtuin HSP	Cancer
HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and *HSP*70, with IC₅₀ of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity .

HY-149637

HSP70/SIRT2-IN-1	Sirtuin HSP	Cancer
HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and *HSP*70, with IC₅₀ of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity .

HY-D0484

C.I. Disperse yellow 70	Fluorescent Dye
C.I. Disperse yellow 70 is a yellow dye commonly used for fiber dyeing.

HY-120400

KDM5-C70 4 Publications Verification	Histone Demethylase	Cancer
KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels .

HY-167600AS

18:0 PA-d70	Isotope-Labeled Compounds	Others
18:0 PA-d₇₀ is deuterium labeled 18:0 PA0 .

HY-157570

Anti-inflammatory agent 70	PROTACs STING	Infection
Anti-inflammatory agent 70 (N-Me-SP23) is a STING protein PROTAC degrader and inhibits the STING signaling pathway. Anti-inflammatory agent 70 has anti-inflammatory activity. (Pink: STING inhibitor (HY-47709); Black: linker (HY-W008296); Blue: CRBN Ligand (HY-W460193)) .

HY-12622

HSP70-IN-1 1 Publications Verification	HSP	Cancer
HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC₅₀ of 2.3 μM.

HY-P990534

Anti-TSHR Antibody (K1-70) K1-70	TSH Receptor	Inflammation/Immunology
Anti-TSHR Antibody (K1-70) is a CHO-expressed human antibody that targets TSHR. Anti-TSHR Antibody (K1-70) has a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 143.54 kDa. For the isotype control of Anti-TSHR Antibody (K1-70), you can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-103158

BW B70C	Lipoxygenase	Others
BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent .

HY-111079

HIV-1 inhibitor-70	HIV Reverse Transcriptase	Others
HIV-1 inhibitor-70 (compound 20) is a bifunctional inhibitor that inhibits both wild-type (WT) and K103N mutant reverse transcriptases (RTs) of HIV-1.

HY-157717

HSD17B13-IN-70	17β-HSD	Metabolic Disease
HSD17B13-IN-70 (Compound 39) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC₅₀ value of < 0.1 μM for estradiol. HSD17B13-IN-70 can be used for research on liver diseases or metabolic disorders .

HY-P1505A

C3a (70-77) (TFA) 1 Publications Verification Complement 3a (70-77) (TFA)	Complement System	Inflammation/Immunology
C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a .

HY-111086

DG70 GSK1733953A	Bacterial	Infection
DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC₅₀ value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research .

HY-P5449

p70 S6 Kinase substrate	Ribosomal S6 Kinase (RSK)	Others
p70 S6 Kinase substrate is a biological active peptide. (This peptide is a substrate for p70 ribosomal S6 kinase.)

HY-15528

kb NB 142-70	PKD	Cancer
kb NB 142-70 is a potent PKD inhibitor, with IC₅₀s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity.

HY-105537

Ro 70‐0004 RS-100975	Adrenergic Receptor	Endocrinology
Ro 70-0004 (RS-100975) is a selective alpha1A-adrenoceptor antagonist with a pK_i of 8.9. Ro 70‐0004 can be used in the study of prostatic hyperplasia .

HY-P1505

C3a (70-77) Complement 3a (70-77)	Complement System	Inflammation/Immunology
C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.

HY-164389

SML-10-70-1	Ras	Cancer
SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC₅₀ of 26.6-47.6 μM .

HY-P3867

Hypocretin (70-98), human	Orexin Receptor (OX Receptor) Apoptosis	Cancer
Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13595

Chrysophanol 3 Publications Verification Chrysophanic acid	Quinones Structural Classification Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	EGFR
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and *mTOR/p70S6K*.

HY-N1050

Zederone	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma elata Roxb. Zingiberaceae	mTOR
Zederone, a germacrane-type sesquiterpene, has potently cytotoxic against human white blood cancer cells and human prostate cancer cells. Zederone significantly inhibits the proliferation and downregulates the protein expressions of mTOR, and phosphorylated p70 S6 kinase (p-p70s6K) in SKOV3 cells .

HY-N13173

α-Glucosidase-IN-70	Quinones Structural Classification Anthraquinones Source classification Gentianaceae Swertia mussotii Franch. Plants	Glycosidase
α-Glucosidase-IN-70 (compound 9) is an α-glucosidase inhibitor (IC₅₀=31.1 μM) isolated from the traditional Chinese herbal medicine Swertia mussotii. α-Glucosidase-IN-70 can be used in the research of diabetes .

HY-126601

Malonganenone A	Infection Structural Classification Alkaloids Classification of Application Fields Animals Other Alkaloids Source classification Disease Research Fields	Parasite HSP
Malonganenone A is an antimalarial marine alkaloid that disrupts the interaction between *PfHsp70-x* and Hsp40. Malonganenone A inhibits plasmodial and not human Hsp70 ATPase activity (Hsp40-stimulated), and hindered the aggregation suppression activity of PfHsp70-x .

HY-N1333

Rubioncolin C	Quinones Monophenols Classification of Application Fields Rubia podantha Source classification Rubiaceae Phenols Plants Naphthalene Quinones Disease Research Fields Cancer	NF-κB
Rubioncolin C exerts anti-tumor activity by inducing apoptotic and autophagic Cell Death and inhibiting the NF-κB and *Akt/mTOR/P70S6K* Pathway in Human Cancer Cells .

HY-13595R

Chrysophanol (Standard) Chrysophanic acid (Standard)	Quinones Structural Classification Rheum palmatum L. Classification of Application Fields Polygonaceae Source classification Phenols Plants Disease Research Fields Cancer	EGFR
Chrysophanol (Standard) is the analytical standard of Chrysophanol. This product is intended for research and analytical applications. Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and *mTOR/p70S6K*.

HY-N6572

Sutchuenmedin A	Epimedium sutchuenense Franch. Flavonols Flavonoids Monophenols Classification of Application Fields Source classification Other Diseases Phenols Plants Berberidaceae Disease Research Fields	Others
Sutchuenmedin A is a prenylflavonoid. Sutchuenmedin A is isolated from the 70% EtOH extract of Epimedium sutchuenense .

HY-N10864

Imbricataflavone A	Structural Classification Flavonoids Source classification Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Others
Imbricataflavone A, a imbricataflavone, can be isolated from 70% ethanol extract of C. chinensis .

HY-N12427

Litchinol B	Structural Classification Monophenols Litchi Chinensis Sonn. Source classification Sapindaceae Phenols Plants	Tyrosinase
Litchinol B (compound 2) is a non-competitive tyrosinase inhibitor with an inhibition constant of 5.70 μM .

HY-N11521

7-Methoxy obtusifolin	Cassia tora (L.) Roxb. Quinones Structural Classification Leguminosae Anthraquinones Source classification Plants	Tyrosinase
7-Methoxy obtusifolin (Compound 4) is a competitive tyrosinase inhibitor with an IC₅₀ of 7.0 μM .

HY-W127740

α-Cetone Isomethyl-α-ionone; α-Isomethylionone	Microorganisms Source classification	Biochemical Assay Reagents
Isonaline 70 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N2053

Physalin L	Structural Classification Natural Products Physalis minima Linn. Source classification Solanaceae Plants	NO Synthase Endogenous Metabolite
Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity .

HY-N10268

3-Hydroxyterphenyllin NSC 299113	Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	Apoptosis
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .

HY-N14247

Exfoliazone	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Fungal
Exfoliazone is a phenoxazine antibiotic. Exfoliazone has the activity of resisting Valsa ceratosperma, and the ED₅₀ that inhibits mycelial growth is 70 μg/mL .

HY-N7985

Pendulone	Infection Quinones Monophenols other families Classification of Application Fields Source classification Phenols Benzene Quinones Plants Disease Research Fields	Parasite Bacterial
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC₅₀ of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .

HY-N7085

Citropten 5,7-Dimethoxycoumarin; Limettin	Structural Classification Natural Products Classification of Application Fields Rutaceae Plants Disease Research Fields Citrus medica Linn. var. sarcodactylis (Noot.) Swingle Cancer	JNK p38 MAPK ERK
Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .

HY-N0754

Eupalinolide A	Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Inflammation/Immunology	HSP
Eupalinolide A, isolated from Eupatorium lindleyanum, induces the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90 .

HY-N8979

Kanshone A	Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Others
Kanshone A is a sesquiterpene isolated from the roots of Nardostachys chinensis (Valerianaceae). Kanshone A shows cytotoxic with an IC₅₀ value of 7.0 µg/ml in P388 cells .

HY-N2073

Ethyl linolenate	Cardiovascular Disease Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields	MCHR1 (GPR24)
Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC₅₀ of 70 μM. Anti-melanogenesis Effects .

HY-N14105

Cinatrin C3	Structural Classification Natural Products Microorganisms Source classification	Phospholipase
Cinatrin C3 is a phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 μM and can be extracted from Circinotrichum falcatisporum RF-641 .

HY-13005

Fagomine 5+ Cited Publications D-Fagomine	Structural Classification Fagopyrum esculentum Moench Classification of Application Fields Polygonaceae Source classification Metabolic Disease Plants Disease Research Fields Saccharides Monosaccharides	Glycosidase
Fagomine is a mild glycosidase inhibitor. The K_i of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.

HY-N7085R

Citropten (Standard)	Structural Classification Natural Products Rutaceae Plants Citrus medica Linn. var. sarcodactylis (Noot.) Swingle	ERK JNK p38 MAPK
Citropten (Standard) is the analytical standard of Citropten. This product is intended for research and analytical applications. Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .

HY-N9532

Isobyakangelicol Anhydrobyakangelicin	Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt. Disease Research Fields Cancer	Others
Isobyakangelicol is a coumarin that can be found in the roots of Angelica dahurica. Isobyakangelicol inhibits the growth of HeLa and HepG2 cells, with IC₅₀s of 70.04 μM and 17.97 μM .

HY-W127740R

α-Cetone (Standard)	Microorganisms Source classification	Biochemical Assay Reagents
α-Cetone (Standard) is the analytical standard of α-Cetone. This product is intended for research and analytical applications. Isonaline 70 is an industrial solvent that belongs to the family of high flash point aromatic naphtha solvents. It is commonly used in a variety of industries including paints and coatings, adhesives and rubber manufacturing, as a thinner and thinner for resins and polymers. Isonaline 70 has various properties that make it suitable for these applications, including its low viscosity, high solvency and good compatibility with other materials. In addition, it can also be used as a cleaning agent for mechanical equipment.

HY-N10863

Aurantiamide benzoate	Structural Classification Alkaloids Source classification Celastraceae Pyridine Alkaloids Celastrus rugosus Rehd. et Wils. Plants	Xanthine Oxidase
Aurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC₅₀ value of 70 μM .

HY-N6310

Talaromycesone A	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Bacterial
Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC₅₀ of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC₅₀ of 7.49 μM .

HY-N8107

Matairesinol monoglucoside	Structural Classification Monophenols other families Classification of Application Fields Source classification Lignans Other Diseases Phenols Phenylpropanoids Plants Disease Research Fields	STAT
Matairesinol monoglucoside, a lignan compound, exhibits low activity on IFN-γ/STAT1 and IL-6/STAT3 signaling pathways with inhibition ratio of 5.8% and 7.0%, respectively .

HY-B1864A

Kasugamycin hydrochloride 1 Publications Verification Ksg hydrochloride	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Biological Pesticide Research Plant agriculture research Agricultural Research Infection Microorganisms Antibiotics Resistance Selection Disease Research Fields	Bacterial Antibiotic
Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-N13121

Daphnegiravone D	Structural Classification Flavonoids Flavones Thymelaeaceae Source classification Daphne giraldii Nitsche Plants	HDAC Apoptosis p38 MAPK
Daphnegiravone D (compound 70) is an HDAC6 inhibitor with anti-hepatocellular carcinoma activity. Daphnegiravone D can induce apoptosis and selectively inhibit the proliferation of liver cancer cells through the p38 and JNK MAPK pathways .

HY-B0471

Phenylephrine hydrochloride Maximum Cited Publications 19 Publications Verification (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride	Cardiovascular Disease Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
(R)-(-)-Phenylephrine hydrochloride is a selective α₁-adrenoceptor agonist with pK_is of 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

HY-N1235

Skullcapflavone I Panicolin	Structural Classification Flavonols Flavonoids Labiatae Source classification Plants Medicago truncatula Gaertn.	Elastase MicroRNA
Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC₅₀s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a .

HY-N2073R

Ethyl linolenate (Standard)	Structural Classification Natural Products other families Source classification Plants	MCHR1 (GPR24)
Ethyl linolenate (Standard) is the analytical standard of Ethyl linolenate. This product is intended for research and analytical applications. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects .

HY-N8380

(-)-Latifolin	Structural Classification Dalbergia hupeana Hance Source classification Phenols Polyphenols Plants Fabaceae	Apoptosis Autophagy PI3K Necroptosis
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting *PI3K/AKT/mTOR/p70S6K* signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities .

HY-W392548

1-O-(4-Hydroxybenzoyl)-glycerol	Structural Classification Monophenols Brahea armata S.Watson Source classification Phenols Arecaceae Plants	Bacterial Fungal
1-O-4-Hydroxybenzoyl-glycerol is an antimicrobial agent against Staphylococcus aureus, Escherichia coli, Saccharomyces cerevisiae, and Fusarium culmorum (20 mM, maximum inhibition rate: 70%). 1-O-(4-Hydroxybenzoyl)-glycerol stimulates low skin irritation .

HY-125416

Streptothricin F	Microorganisms Source classification	Antibiotic Bacterial
Streptothricin F is a bactericidal antibiotic. Streptothricin F interacts with the 30S subunit of 70S ribosome. Streptothricin F shows rapid, bactericidal activity against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) (MIC₅₀ and MIC₉₀: 2 and 4 μM, respectively) and Acinetobacter baumannii .

HY-N10259

Norfunalenone	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	Bacterial
Norfunalenone exhibits weak cytotoxic activity in mouse myeloma NS-1 cell line (ATCC TIB-18) with an IC₅₀ of 70 μM. Norfunalenone also exhibits weak antibacterial activity against B. subtilis (MIC=100 μg/mL; IC₅₀=265 μM) .

HY-B1864AR

Kasugamycin (hydrochloride) (Standard)	Structural Classification Microorganisms Antibiotics Resistance Selection Source classification Antibacterial Disease Research Other Antibiotics Plant agriculture research	Bacterial Antibiotic
Kasugamycin (hydrochloride) (Standard) is the analytical standard of Kasugamycin (hydrochloride). This product is intended for research and analytical applications. Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-N7151R

Aurachin D (Standard)	Structural Classification Alkaloids Microorganisms Source classification Quinoline Alkaloids	Antibiotic Bacterial Fungal
Kasugamycin (hydrochloride) (Standard) is the analytical standard of Kasugamycin (hydrochloride). This product is intended for research and analytical applications. Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-N10132

Microgrewiapine A	Malvaceae Structural Classification Alkaloids Microcos paniculata L. Other Alkaloids Source classification Plants	nAChR
Microgrewiapine A is an antagonist of nAChR. Microgrewiapine A inhibits hα4β2 and hα3β4 activity with 60% and 70% inhibition, respectively. Microgrewiapine A has selective cytotoxic against HT-29 human colon cancer cells with an IC₅₀ of 6.8 μM .

HY-N9629

Cyclooctatin	Structural Classification Natural Products Microorganisms Source classification	Phosphatase
Cyclooctatin can inhibit the hemolysis phospholipase [EC 3.1.1.5] (Lyso-PL) activity. Terpentecin as substrates, it inhibits Lyso-PL, PL-A2, PL-C and PL-D with IC₅₀ of 2.9 μg/mL, 65.0 μg/mL, 70.0 μg/mL and >100 μg/mL, respectively .

HY-135882

OMDM-6	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	TRP Channel Cannabinoid Receptor Endogenous Metabolite
OMDM-6 is a hybrid agonist of vanilloid receptor type 1 (VR1, TRPV1) (EC₅₀=75 nM) and cannabinoid receptor type 1 (CB1) (K_i=3.2 μM). OMDM-6 inhibits anandamide cellular uptake (ACU) with a K_i of 7.0 μM .

HY-B0471R

Phenylephrine (hydrochloride) (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Source classification Phenols Endogenous metabolite	Adrenergic Receptor Endogenous Metabolite
Phenylephrine (hydrochloride) (Standard) is the analytical standard of Phenylephrine (hydrochloride). This product is intended for research and analytical applications. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-N0847

Micheliolide 5+ Cited Publications	Structural Classification Other Monoterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields	NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-N10701

AChE/BChE-IN-11	Structural Classification Oleaceae Syringa oblata Lindl. Source classification Plants Saccharides Monosaccharides	Cholinesterase (ChE)
AChE/BChE-IN-11 (compound 1) is a potent is a dual AChE and BChE inhibitor with IC₅₀ values of 70 and 71 μM for AChE and BChE, respectively. AChE/BChE-IN-11 is a natural product that could be isolated from the leaf of artichoke . AChE/BChE-IN-11 can be used in research of Alzheimer’s disease (AD) research .

HY-N10958

Wikstrol A	Structural Classification Flavonols Flavonoids Microorganisms Source classification	Fungal HIV Microtubule/Tubulin
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM .

HY-16566A

Kanamycin sulfate 10+ Cited Publications Kanamycin A sulfate	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Plant Cell Culture Microorganisms Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields	Bacterial Antibiotic
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

HY-126477

NNK 1 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

HY-N0086R

N6-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Influenza Virus Endogenous Metabolite
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

HY-N3237

Mulberrofuran H	Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	Dopamine Receptor
Mulberrofuran H is a 2-arylbenzofuran derivative from the cultivated mulberry tree (Morus lhou (ser.) Koidz.). Mulberrofuran H demonstrates potent inhibition against substrates L-tyrosine (IC₅₀=4.45 µM) and L-DOPA (IC₅₀=19.70 µM). Mulberrofuran H also shows potent anti-inflammatory and antioxidative activities .

HY-N12147

Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside	Apocynaceae Structural Classification Polysaccharides Source classification Thevetia peruviana (Pers.) K. Schum. Plants Saccharides Monosaccharides	Others
Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside (Compound 12) is a cardiac glycoside that can be isolated from seeds of Thevetia peruvian. Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside shows cytotoxicity against SW1990 and MGC-803 cells (IC₅₀: 9.52 and 7.70 μM) .

Cat. No.	Product Name	Chemical Structure

HY-W040193S

1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d70
1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d₇₀ is the deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].

HY-W269867S

Tetratriacontane-d70
Tetratriacontane-d₇₀ is the deuterium labeled Tetratriacontane[1].

HY-W440986S

Distearoylphosphatidylserine-d70 sodium
Distearoylphosphatidylserine-d70 (sodium) is deuterium labeled (S)-2-amino-2-carboxyethyl ((R)-2,3-bis(stearoyloxy)propyl) phosphate.

HY-167600AS

18:0 PA-d70
18:0 PA-d₇₀ is deuterium labeled 18:0 PA0 .

HY-115415S

1,2-Distearoyl-sn-glycero-3-phosphate-d70 sodium
1,2-Distearoyl-sn-glycero-3-phosphate-d₇₀ (sodium) is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphate.

HY-112530S

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d₇₀ is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis

HY-145742S

1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-d70 sodium
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-d₇₀ (sodium) is deuterium labeled 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is the component of liposomes for drug delivery[1].

HY-B0363S

Nimesulide D5
Nimesulide-d₅ is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].

HY-B0363S1

Nimesulide-13C6
Nimesulide- ¹³C₆ (R805- ¹³C₆) is ¹³C labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-17504BS2

Rosuvastatin-13C,d3 sodium

Rosuvastatin- ¹³C,d₃ sodium is ¹³C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

HY-17504AS1

Rosuvastatin-d6

Rosuvastatin-d₆ (ZD 4522-d₆) is deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks hERG current with an IC₅₀ of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

HY-N2073S

Ethyl linolenate-d5
Ethyl linolenate-d₅ is the deuterium labeled Ethyl linolenate. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects[1].

HY-B0110S

Gestodene-d6
Gestodene-d₆is the deuterium labeled Gestodene. Gestodene(SHB 331) is a progestogen hormonal contraceptive[1][2]. Gestodene-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0471S

Phenylephrine-d3 hydrochloride
Phenylephrine-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S3

Phenylephrine-d6 hydrochloride
Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0471S2

(S)-Phenylephrine-d6 hydrochloride
(S)-Phenylephrine-d₆ (hydrochloride) is deuterium labeled Phenylephrine (hydrochloride). (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-B0239S3

Chloramphenicol-d4
Chloramphenicol-d₄ is deuterium labeled Chloramphenicol. Chloramphenicol，a broad-spectrum antibiotic，acts as a potent inhibitor of bacterial protein biosynthesis[1][2]. Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity[3].

HY-B0471S1

Phenylephrine-2,4,6-d3 hydrochloride
Phenylephrine-2,4,6-d₃ (hydrochloride) is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

HY-14153S

Tegaserod-d11

Tegaserod-d₁₁ is deuterated labeled Tegaserod (HY-14153). Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist. Tegaserod has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

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