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Pathways Recommended:	Apoptosis Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

induce tumor cell apoptosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (391) TNF Receptor (3) 5 alpha Reductase (1) ADC Cytotoxin (6) Adrenergic Receptor (2) Akt (15) AMPK (1) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (8) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (10) Antibody-Drug Conjugates (ADCs) (1) AP-1 (2) Aryl Hydrocarbon Receptor (1) ASCT (2) ATM/ATR (2) Aurora Kinase (2) Autophagy (54) Bacterial (20) Bcl-2 Family (15) Bcr-Abl (1) c-Fms (3) c-Kit (3) c-Met/HGFR (9) c-Myc (10) Cannabinoid Receptor (1) Casein Kinase (1) Caspase (18) CDK (15) Ceramidase (1) Chloride Channel (2) ClpP (1) Complement System (1) COX (9) CRISPR/Cas9 (1) CXCR (3) Cytochrome P450 (1) Deubiquitinase (4) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (1) DNA/RNA Synthesis (19) Drug Derivative (1) Drug Metabolite (2) DYRK (1) E1/E2/E3 Enzyme (5) EGFR (12) Endogenous Metabolite (12) Epigenetic Reader Domain (3) ERK (9) Estrogen Receptor/ERR (3) Eukaryotic Initiation Factor (eIF) (1) FAK (7) Fatty Acid Synthase (FASN) (3) Ferroptosis (4) FGFR (2) FKBP (3) FLT3 (4) Fungal (5) FXR (1) G-quadruplex (2) GABA Receptor (3) Galectin (1) Gli (1) GLUT (2) Glutaminase (2) Glutathione S-transferase (1) Glycosidase (1) GSK-3 (1) HCV (1) HDAC (20) Hedgehog (3) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (4) Histone Demethylase (1) Histone Methyltransferase (2) HIV (3) HPV (1) HSP (10) HSV (2) IAP (2) IGF-1R (1) IKK (1) Insulin Receptor (1) Integrin (3) Interleukin Related (4) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (5) JAK (7) JNK (3) Keap1-Nrf2 (2) KLF (1) Lactate Dehydrogenase (3) LXR (1) MDM-2/p53 (17) MEK (2) MELK (1) METTL3 (2) MicroRNA (1) Microtubule/Tubulin (28) Mitochondrial Metabolism (6) Mitophagy (1) MMP (3) Monoamine Oxidase (1) Mps1 (1) mTOR (13) nAChR (1) Necroptosis (5) NF-κB (13) NO Synthase (2) NOD-like Receptor (NLR) (2) Notch (1) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (2) Oct3/4 (2) Organoid (2) Orthopoxvirus (2) P-glycoprotein (3) P2X Receptor (2) p38 MAPK (1) Parasite (12) PARP (7) PDHK (2) PDK-1 (2) PERK (1) PGE synthase (2) Phosphatase (4) PI3K (18) Pim (1) PKA (2) PKC (3) PKD (1) Polo-like Kinase (PLK) (3) Progesterone Receptor (1) Prostaglandin Receptor (1) PROTACs (8) Proteasome (1) Proton Pump (1) PTEN (4) Pyroptosis (2) Raf (3) Ras (4) Reactive Oxygen Species (29) RIP kinase (1) ROS Kinase (7) RSV (2) Ser/Thr Protease (2) Serotonin Transporter (2) SF3B1 (1) Smo (3) Somatostatin Receptor (1) SphK (1) Src (3) STAT (10) Stearoyl-CoA Desaturase (SCD) (1) STING (1) Survivin (2) Telomerase (1) Thymidylate Synthase (2) Toll-like Receptor (TLR) (2) Topoisomerase (20) Trk Receptor (2) TrxR (2) VD/VDR (2) VEGFR (4) Wnt (4) Xanthine Oxidase (1) YAP (1) α-synuclein (2) β-catenin (7) γ-secretase (1)
By Research Areas:	Cancer (439) Cardiovascular Disease (15) Endocrinology (3) Infection (40) Inflammation/Immunology (56) Metabolic Disease (16) Neurological Disease (30)
Click Chemistry:	Azide (2) Alkynes (1)
Oligonucleotides:	Nucleosides and their Analogs (1) Antisense Oligonucleotides (5) Cholesterol (1)

452

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Apoptosis TNF Receptor BRK Itk TOPK SNIPERs NAMPT ALCAM/CD166 GDNF Receptor VISTA BCL6 ASK1 Tim3 BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126856

HC-Toxin	HDAC Apoptosis	Cancer
HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC₅₀ of 30 nM . HC-Toxin induces tumor cell *apoptosis* and has anticancer effects .

HY-N7000

Perillyl alcohol	Apoptosis Endogenous Metabolite	Cancer
Perillyl alcohol, a monoterpene, is active in inducing *apoptosis* in tumor cells without affecting normal cells .

HY-N8207

Gypenoside LI	Apoptosis MicroRNA	Cancer
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .

HY-122760

Bax activator-1 1 Publications Verification	Bcl-2 Family Apoptosis	Cancer
Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis .

HY-122724

IQDMA	Apoptosis	Cancer
IQDMA is an anti-tumor compound. IQDMA can induce apoptosis in tumor cells, such as K562 cells .

HY-105172A

TT-232 TFA CAP-232 TFA; TLN-232 TFA	Somatostatin Receptor Apoptosis	Cancer
TT-232 TFA (CAP-232 TFA) is an analogue of somatostatin. TT-232 TFA can induce apoptosis of pancreatic tumor cell lines, inhibit tyrosine kinase activity and stimulate tyrosine phosphatase activity in colon tumor cell lines. TT-232 TFA inhibits the proliferation of tumor cells, induces *apoptosis* of tumor cells and shows strong anti-tumor effects. TT-232 TFA can be used in the development of anti-tumor drugs and the study of apoptosis mechanism .

HY-119616

Phenamet	Apoptosis	Cancer
Phenamet is an anti-tumor agent that can inhibit tumor growth and slow the progression of cancer. Phenamet prevents the reproduction of tumor cells by interfering with the growth and division of cancer cells. In addition, Phenamet can induce apoptosis in cancer cells, thereby eliminating tumor cells.

HY-168589

Apoptosis inducer 30	Apoptosis Cytochrome P450 Caspase Reactive Oxygen Species	Cancer
Apoptosis inducer 30 (Compound 15a) is an anticancer agent. Apoptosis inducer 30 induces MCF-7 cells *apoptosis* through mitochondrial pathway. Apoptosis inducer 30 induces intracellular reactive oxygen species levels and decreases mitochondrial membrane potential, and blocks the cell cycle in the G0/G1 phase. Apoptosis inducer 30 inhibits cell growth, with an IC₅₀ value of 0.32 μM against MCF-7 cells, and inhibits tumor growth in a mouse model of breast cancer .

HY-117515

YLT205	Apoptosis	Cancer
YLT205 is an anticancer agent and induces **cell apoptosis*. YLT205 inhibits tumor* growth in vivo and in vitro .

HY-129715

MPI-0441138	Apoptosis	Cancer
MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death .

HY-135217

Apiole	Apoptosis	Cancer
Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model .

HY-N10520

Pectic acid Methyl protopectin; Polygalacturonic acid	Apoptosis Necroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell *apoptosis* and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease .

HY-N0797

(20S)-Protopanaxadiol 20-Epiprotopanaxadiol; 20(S)-APPD	P-glycoprotein Reactive Oxygen Species Apoptosis	Cancer
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-P99934

Eftozanermin alfa ABBV-621	Apoptosis	Cancer
Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces *apoptosis* in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .

HY-P2322

Iturin A 1 Publications Verification	Fungal Reactive Oxygen Species Apoptosis Autophagy	Infection Cancer
Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces *apoptosis* and autophagy in tumor cells. Iturin A has antitumor activity .

HY-168720

Apoptosis inducer 32	Apoptosis	Cancer
Apoptosis inducer 32 (Compound 7g) is an *apoptosis* inducer with a K_D of 42 μM, showing anti-tumor activity. Apoptosis inducer 32 caused significant cellular morphological changes in MDA-MB-231 cells, including membrane bubbling, nuclear fragmentation, and apoptotic body formation. The IC₅₀ of Apoptosis inducer 32 in MCF-7, MDA-MB-231, and HEK cells is 4.77, 6.56 and 337.8 μM respectively .

HY-145729A

Danvatirsen sodium AZD9150 sodium	Apoptosis STAT	Cancer
Danvatirsen sodium is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen sodium binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

HY-145729

Danvatirsen AZD9150	STAT Apoptosis	Cancer
Danvatirsen is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

HY-14808

Adarotene 5+ Cited Publications ST1926	Apoptosis	Cancer
Adarotene is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.

HY-124624

PBOX-15	Microtubule/Tubulin Apoptosis	Cancer
PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells .

HY-N7223

Lappaol F	YAP Apoptosis	Cancer
Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP<、b> mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell *apoptosis, and inhibits tumor* growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae) .

HY-120429

SKLB-163	Apoptosis	Cancer
SKLB-163 is an orally active inhibitor for Rho GDP-dissociation (RhoGDI). SKLB-163 inhibits highly expressed RhoGDI tumor cell proliferation and migration, and increases radiosensitivity of tumor cells. SKLB-163 induces cancer cell *Apoptosis* .

HY-N11638

Ganoderic acid R	Apoptosis	Cancer
Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing *apoptosis* on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1) .

HY-162863

ERK-MYD88 interaction inhibitor 1	Apoptosis	Cancer
ERK-MYD88 interaction inhibitor 1 is an ERK-MYD88 interaction inhibitor. ERK-MYD88 interaction inhibitor 1 can induce an HRI-mediated integrated stress response (ISR), leading to cancer cell-specific immunogenic cell apoptosis (apoptosis). ERK-MYD88 interaction inhibitor 1 can induce anti-tumor T cell responses in Lewis lung cancer mice, exhibiting anti-tumor activity .

HY-N2632

Uvarigrin	Apoptosis	Cancer
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation .

HY-114440

Belapectin GR-MD-02	Galectin Apoptosis	Cancer
Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell *Apoptosis. Belapectin promotes tumor* regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity K_i of 2.8 μM .

HY-121410

Narasin	Bacterial Apoptosis Parasite NF-κB Antibiotic	Infection Cancer
Narasin is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells *apoptosis*. Narasin has antimicrobial and anticancer activity .

HY-N3055

Pinusolide	Apoptosis	Cancer
Pinusolide is a known platelet-activating factor (PAF) receptor binding antagonist. Pinusolide not only decreases the proliferation activity of tumor cells but specifically induces *apoptosis* .

HY-151620

Antitumor agent-80	Apoptosis	Cancer
Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces *apoptosis* in tumor cells .

HY-112225

Narasin sodium	Antibiotic Bacterial Parasite NF-κB Apoptosis	Infection Cancer
Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells *apoptosis*. Narasin sodium has antimicrobial and anticancer activity .

HY-N10355

27-TBDMS-4-Dehydrowithaferin A	Apoptosis	Cancer
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells *apoptosis*. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .

HY-N0706

Gracillin 1 Publications Verification	Apoptosis Autophagy	Cancer
Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .

HY-14815

Fosbretabulin Combretastatin A4 phosphate	Apoptosis Microtubule/Tubulin	Cancer
Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing *apoptosis, and suppressing angiogenesis in tumors* .

HY-19471

(rac)-ZK-304709	Others	Cancer
(rac)-ZK-304709 is an isomer of ZK-304709. It is a first-in-class oral multi-target tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (Cdks), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. It directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. In an orthotopic BON tumor model, (rac)-ZK-304709 reduced primary tumor growth by 80% and reduced tumor microvascular density. These results suggest that (rac)-ZK-304709 can effectively control tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may be a potential agent for the treatment of NET.

HY-121512

SK-7041	HDAC Apoptosis	Cancer
SK-7041 is a HDAC inhibitor with the IC₅₀ of 172 nM. SK-7041 induces the hyperacetylation of histones H3 and H4 .SK-7041 inhibits tumor cell growth in vivo and in vitro, induces cell *apoptosis, and arrests cell* cycle at the G1 phase .

HY-135217R

Apiole (Standard)	Apoptosis	Cancer
Apiole (Standard) is the analytical standard of Apiole. This product is intended for research and analytical applications. Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model .

HY-W013032

Oxamic acid 5+ Cited Publications Oxamidic acid	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce *apoptosis* .

HY-N6601

Pomolic acid Randialic acid A	Apoptosis	Cancer
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from?Euscaphis japonica?(Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell *apoptosis*. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC) .

HY-128972

Purpurin 18 2 Publications Verification	Reactive Oxygen Species Apoptosis	Others
Purpurin 18, a derivative of chlorophyll and a type of dihydroporphyrin, is used to produce photosensitizers. Purpurin 18 photodynamic therapy can induce cell *apoptosis* and has anti-tumor activity .

HY-111838

ZZW-115	Apoptosis	Cancer
ZZW-115 is a potent NUPR1 inhibitor, with a K_d of 2.1 μM. ZZW-115 induces tumor cell death by necroptosis and *apoptosis*. Anticancer activity .

HY-111838A

ZZW-115 hydrochloride 3 Publications Verification	Apoptosis	Cancer
ZZW-115 hydrochloride is a potent NUPR1 inhibitor, with a K_d of 2.1 μM. ZZW-115 hydrochloride induces tumor cell death by necroptosis and *apoptosis*. Anticancer activity .

HY-N0114A

(±)-Evodiamine	Topoisomerase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
(±)-Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their *apoptosis* .

HY-14429

(-)-Irofulven MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863	DNA Alkylator/Crosslinker Apoptosis	Cancer
(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells *apoptosis*, and has potent antitumor activity .

HY-N2198

Podocarpusflavone A	Topoisomerase Apoptosis	Cancer
Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor agents .

HY-W013032A

Oxamic acid sodium 5+ Cited Publications Sodium oxamate	Lactate Dehydrogenase Apoptosis	Cancer
Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce *apoptosis* .

HY-13566

Belotecan CKD-602 free base	Topoisomerase Apoptosis	Cancer
Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer .

HY-11005

BX-912 4 Publications Verification	PDK-1 Apoptosis	Cancer
BX-912 is a direct, selective, and ATP-competitive PDK1 inhibitor (IC₅₀=26 nM). BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces *apoptosis* .

HY-10222

Ixabepilone 5 Publications Verification BMS-247550; Aza-epothilone B	Microtubule/Tubulin Apoptosis Bacterial	Cancer
Ixabepilone (BMS-247550) is an orally bioavailable?microtubule?inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.

HY-N0211

Cyasterone 1 Publications Verification	EGFR Apoptosis	Cancer
Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced *apoptosis* and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .

HY-164500

MC3629	Apoptosis Histone Methyltransferase	Cancer
MC3629 is an inhibitor of histone methyltransferase (EZH2) with anti-tumor activity. MC3629 inhibits SHH MB cancer cell proliferation and self-renewal and induces *apoptosis. MC3629 can be used to study drug resistance in tumor* aggressiveness .

Cat. No.	Product Name

HY-L135

Cancer Stem Cells Compound Library

2,427 compounds

With the progress of modern cancer therapy, the life of cancer patients has been extended. However, after initial treatment and recovery, the development of secondary tumors often leads to cancer recurrence. Cancer stem cells are a small number of cells that tumor growth and reproduction depend on.

Cancer stem cells have strong self-renewal ability, which is the direct cause of tumor occurrence. In addition, cancer stem cells also have the ability to differentiate into different cell types, playing a crucial role in tumor metastasis and development. Chemotherapy and radiotherapy induced DNA damage and apoptosis are common cancer treatments. However, cancer stem cells can effectively protect cancer cells from apoptosis by activating DNA repair ability. Cancer stem cells are regarded as the key "seed" of tumor occurrence, development, metastasis and recurrence. Since its first discovery in leukemia in 1994, cancer stem cells have been considered a promising therapeutic target for cancer treatment.

MCE supplies a unique collection of 2,427 compounds targeting key proteins in cancer stem cells. MCE Cancer Stem Cells Compound Library is a useful tool for cancer stem cells related research and anti-cancer drug development.

HY-L133

Cuproptosis Compound Library

237 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 237 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P2322

Iturin A 1 Publications Verification	Fungal Reactive Oxygen Species Apoptosis Autophagy	Infection Cancer
Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces *apoptosis* and autophagy in tumor cells. Iturin A has antitumor activity .

HY-P10832

ATWLPPRAANLLMAAS	Apoptosis Ras Raf MEK ERK Caspase PARP Bcl-2 Family	Cancer
ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce *apoptosis*. .

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell *apoptosis* through a p53-independent pathway. Baceridin can be used in cancer research .

HY-P10387

RSM3	METTL3 Apoptosis	Cancer
RSM3, a stapled peptide, is a METTL3-METTL14 inhibitor with an K_d of 3.10 μM. RSM3 inhibits tumor growth while induces **cell apoptosis**. RSM3 can be used for study of cancer .

HY-P10387A

RSM3 TFA	METTL3 Apoptosis	Cancer
RSM3 TFA, a stapled peptide, is a METTL3-METTL14 inhibitor with an K_d of 3.10 μM. RSM3 TFA inhibits tumor growth while induces **cell apoptosis**. RSM3 TFA can be used for study of cancer .

HY-P10511

Pantinin-3	Apoptosis	Infection Cancer
Pantinin-3 is an antimicrobial peptide with antitumor activity found in the venom of the emperor scorpion (Pandinus imperator). Pantinin-3 shows selective toxicity against breast cancer cells (MDA-MB-231) and prostate cancer cells (DU-145). Pantinin-3 can induce apoptosis in tumor cells. Pantinin-3 can be used in cancer research .

HY-P4056

CIGB-300 P15-Tat	Casein Kinase	Cancer
CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase CK2. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research .

HY-P5910

Azurin p28 peptide	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces *apoptosis* or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P10508

Pantinin-1	Bacterial Apoptosis	Infection Cancer
Pantinin-1 is an antimicrobial peptide found in the venom of the Pandinus imperator scorpion. Pantinin-1 has potent antimicrobial activity against Gram-positive bacteria and fungi, weak antimicrobial activity against Gram-negative bacteria, and very low hemolytic activity against human erythrocytes. Pantinin-1 also has anticancer activity and can induce *apoptosis* in tumor cells .

HY-P5910A

Azurin p28 peptide TFA	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide TFA is a tumor-penetrated antitumor peptide. Azurin p28 peptide TFA redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide TFA induces *apoptosis* or cell cycle arrest. Azurin p28 peptide TFA inhibits p53-positive tumor growths. Azurin p28 peptide TFA shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P10393

ERα17p ERα (295-311)	Apoptosis	Cancer
ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D, and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathways. ERα17p inhibits proliferations of breast cancer cells, induces *apoptosis, and inhibits tumor* growth in mouse models .

Cat. No.	Product Name	Target	Research Area

HY-P99934

Eftozanermin alfa ABBV-621	Apoptosis	Cancer
Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces *apoptosis* in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .

HY-P99270

Tigatuzumab CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody	Apoptosis	Cancer
Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell *apoptosis* of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of *TNF-like weak inducer* of apoptosis (TWEAK)*. TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces* tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P99275

Patritumab 1 Publications Verification Human Anti-ERBB3 Recombinant Antibody	EGFR Akt ERK PARP Survivin	Cancer
Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell *apoptosis* and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors .

HY-P99413

IMAB027 ASP1650	HCV	Cancer
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 ⁺ ovarian and testicular cancer cell lines .

HY-P99956

Zilovertamab vedotin VLS-101; MK-2140	Antibody-Drug Conjugates (ADCs) Apoptosis	Cancer
Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces *apoptosis*. Zilovertamab vedotin can be used in research of cancer .

HY-P99284

Dalotuzumab MK-0646; h7C10	IGF-1R Apoptosis	Cancer
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces *apoptosis* and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7000

Perillyl alcohol	Other Monoterpenes other families Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Perillyl alcohol, a monoterpene, is active in inducing *apoptosis* in tumor cells without affecting normal cells .

HY-N8207

Gypenoside LI	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Cancer	Apoptosis MicroRNA
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .

HY-N0797

(20S)-Protopanaxadiol 20-Epiprotopanaxadiol; 20(S)-APPD	Panax ginseng C. A. Meyer Triterpenes Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	P-glycoprotein Reactive Oxygen Species Apoptosis
20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-135217

Apiole	Structural Classification Natural Products Source classification Plants Umbelliferae Petroselinum crispum (Mill.) Fuss	Apoptosis
Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model .

HY-N10520

Pectic acid Methyl protopectin; Polygalacturonic acid	Structural Classification Natural Products Classification of Application Fields Source classification Rutaceae Plants Endogenous metabolite Citrus reticulata Blanco Human Gut Microbiota Metabolites Polysaccharides Microorganisms Inflammation/Immunology Disease Research Fields Saccharides Cancer	Apoptosis Necroptosis Endogenous Metabolite
Pectic acid (Methyl protopectin), a polygalacturonic acid, induces cell *apoptosis* and necrosis in pituitary tumor cells. Pectic acid can be used in the research of cancers and autoimmune disease .

HY-N7223

Lappaol F	Structural Classification Source classification Lignans Phenylpropanoids Plants Compositae Gueldenstaedtia verna (Georgi) Boriss.	YAP Apoptosis
Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP<、b> mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell *apoptosis, and inhibits tumor* growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae) .

HY-N11638

Ganoderic acid R	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis
Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing *apoptosis* on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1) .

HY-N2632

Uvarigrin	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Apoptosis
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation .

HY-N3055

Pinusolide	Cupressaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer Calocedrus decurrens (Torr.) Florin	Apoptosis
Pinusolide is a known platelet-activating factor (PAF) receptor binding antagonist. Pinusolide not only decreases the proliferation activity of tumor cells but specifically induces *apoptosis* .

HY-112225

Narasin sodium	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Fields Polyether Antibiotics Cancer	Antibiotic Bacterial Parasite NF-κB Apoptosis
Narasin sodium is a cationic ionophore and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells *apoptosis*. Narasin sodium has antimicrobial and anticancer activity .

HY-N10355

27-TBDMS-4-Dehydrowithaferin A	Quinones Classification of Application Fields Source classification Benzene Quinones Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells *apoptosis*. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .

HY-N0706

Gracillin 1 Publications Verification	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis Autophagy
Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .

HY-135217R

Apiole (Standard)	Structural Classification Natural Products Source classification Umbelliferae Plants Petroselinum crispum (Mill.) Fuss	Apoptosis
Apiole (Standard) is the analytical standard of Apiole. This product is intended for research and analytical applications. Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model .

HY-W013032

Oxamic acid 5+ Cited Publications Oxamidic acid	Microorganisms Source classification	Lactate Dehydrogenase Apoptosis
Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce *apoptosis* .

HY-N6601

Pomolic acid Randialic acid A	Triterpenes Structural Classification Euscaphis japonica other families Staphyleaceae Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from?Euscaphis japonica?(Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell *apoptosis*. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC) .

HY-N0114A

(±)-Evodiamine	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids	Topoisomerase Apoptosis
(±)-Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their *apoptosis* .

HY-N2198

Podocarpusflavone A	Structural Classification Flavonoids Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Plants Garcinia subelliptica Biflavones Disease Research Fields Cancer	Topoisomerase Apoptosis
Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor agents .

HY-N0211

Cyasterone 1 Publications Verification	Classification of Application Fields Labiatae Source classification Amaranthaceae Plants Laggera crispata (Vahl) Hepper & J. R. I. Wood Disease Research Fields Achyranthes bidentata Steroids Cancer	EGFR Apoptosis
Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced *apoptosis* and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .

HY-126412

Neochamaejasmine A	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis
Neochamaejasmine A is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L.. Neochamaejasmine A inhibits proliferation, induces cell cycle arrest and *apoptosis* in tumor cells. Neochamaejasmine A can be used in the research of cancers such as prostate cancer, hepatoma cancer .

HY-N0580

Fraxetin 2 Publications Verification	Structural Classification Oleaceae Classification of Application Fields Fraxinus rhynchophylla Hance Coumarins Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Apoptosis Bacterial
Fraxetin is isolated from Fraxinus rhynchophylla Hance and has oral bioactivity. Fraxetin has anti-tumor, antibacterial, antioxidant, and anti-inflammatory effects. Fraxetin can induce cell *apoptosis* .

HY-N12141

Flaccidoside II	Structural Classification Polysaccharides Anemone flaccida Fr. Schmidt Source classification Ranunculaceae Plants Saccharides	Apoptosis
Flaccidoside II inhibits proliferation and induces *apoptosis* in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome .

HY-N10447

Kurzipene D	Terpenoids Source classification Casearia kurzii C. B. Clarke Diterpenoids Plants Salicaceae	Apoptosis
Kurzipene D (compound 4) is a potent anticancer agent. Kurzipene D induces the *apoptosis* and arrested the HepG2 cell cycle at S stage. Kurzipene D shows anti-tumor effects using in vivo zebrafish model. Kurzipene D has the property of inhibiting tumor proliferation and migration .

HY-N7496

Odoroside A	Apocynaceae Structural Classification Natural Products Classification of Application Fields Nerium oleander Plants Disease Research Fields Cancer	Apoptosis
Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. Odoroside A has anti-cancer activity. Odoroside A could induce apoptosis and cell cycle arrest through ROS/p53 signaling pathway, leading to the tumor cell death .

HY-129337

Reveromycin A	Infection Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Antibiotic Fungal Apoptosis
Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing *apoptosis* specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity .

HY-N6031

Dendrophenol Moscatilin	Structural Classification Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Dendrobium chrysanthum Wall. ex Lindl. Cancer	NF-κB Apoptosis COX HIF/HIF Prolyl-Hydroxylase Wnt β-catenin JNK
Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and *apoptosis*. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification .

HY-B0754

Hematoporphyrin Hematoporphyrin IX	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-B0754A

Hematoporphyrin dihydrochloride 10+ Cited Publications Hematoporphyrin IX dihydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-N3442

Juglanin 5 Publications Verification	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	JNK Apoptosis Autophagy
Juglanin, a occurring flavonoid that can be isolated from crude Polygonum aviculare, is a JNK acticator, with anti-inflammatory, anti-oxidant and anti-tumor activities. Juglanin can induce *apoptosis* and autophagy on human breast cancer cells .

HY-N5058

Dehydroeffusol	Structural Classification Natural Products Juncus effusus Linn. Juncaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate *apoptosis*. It shows very low toxicity .

HY-N5106

(E)-Flavokawain A	Structural Classification Chalcones Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis
(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice .

HY-B1610

Sodium citrate dihydrate Maximum Cited Publications 27 Publications Verification Trisodium citrate dihydrate; Citric acid trisodium salt dihydrate	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite Apoptosis
Sodium citrate dehydrate (Trisodium citrate dihydrate) is a natural product with oral activity that can be found in citrus fruits. Sodium citrate dehydrate can inhibit the proliferation of tumor cells and induce *apoptosis. Sodium citrate dehydrate has antibacterial, anti-tumor* and antioxidant activities. Sodium citrate dehydrate can be prepared as a cosolvent or buffer .

HY-N1435

Oroxin B 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Cancer	Apoptosis PI3K PTEN Autophagy
Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early *apoptosis* rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-N0527

Pentagalloylglucose 5+ Cited Publications Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose	Infection Structural Classification other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of *apoptosis* and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

HY-138071

8α-Tigloyloxyhirsutinolide 13-O-acetate 8αTGH	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Dalbergia frutescens (Vell.) Britton	STAT Pyroptosis Apoptosis Reactive Oxygen Species c-Myc Bcl-2 Family TrxR
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, *apoptosis* in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo .

HY-N3085

Phellamurin	Flavanonols Phellodendron amurense Rupr. Flavonoids Classification of Application Fields Source classification Rutaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	P-glycoprotein Apoptosis
Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells *apoptosis* and has anti-tumor activity .

HY-N2420

Flavokawain A 1 Publications Verification	Structural Classification Chalcones Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis
Flavokawain A, a proming anticarcinogenic agent, is a chalcone from kava extract with anti-tumor activity. Flavokawain A induces cell *apoptosis* by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway. Flavokawain A has the potential for the study of bladder cancer .

HY-N6690

Destruxin B	Infection Structural Classification Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields	Bcl-2 Family Caspase Apoptosis
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells . Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated *apoptosis*, not only in vitro but also in vivo .

HY-N6722

Swainsonine 1 Publications Verification Tridolgosir	Infection Alkaloids Piperidine Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Leguminosae Source classification Plants Disease Research Fields Sphaerophysa salsula	Apoptosis Antibiotic
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces *apoptosis* and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .

HY-N0706R

Gracillin (Standard)	Structural Classification other families Source classification Plants Steroids	Apoptosis Autophagy
Gracillin (Standard) is the analytical standard of Gracillin. This product is intended for research and analytical applications. Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .

HY-N0211R

Cyasterone (Standard)	Structural Classification Labiatae Source classification Amaranthaceae Plants Laggera crispata (Vahl) Hepper & J. R. I. Wood Achyranthes bidentata Steroids	EGFR Apoptosis
Cyasterone (Standard) is the analytical standard of Cyasterone. This product is intended for research and analytical applications. Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors .

HY-N2959

Brevilin A 4 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Source classification Plants Compositae Disease Research Fields Cancer	JAK STAT Apoptosis Autophagy
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀=?10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce *apoptosis* and autophagy .

HY-N0797R

(20S)-Protopanaxadiol (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Human Gut Microbiota Metabolites Terpenoids Source classification Plants Endogenous metabolite Araliaceae	P-glycoprotein Reactive Oxygen Species Apoptosis
(20S)-Protopanaxadiol (Standard) is the analytical standard of (20S)-Protopanaxadiol. This product is intended for research and analytical applications. 20S-protopanaxadiol (aPPD) is a metabolite of ginseng saponins, inhibits Akt activity and induces apoptosis in various tumor cells .

HY-N0416

Cucurbitacin B 5+ Cited Publications	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite Disease Research Fields Cancer	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell *apoptosis*. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N0421

Cinobufagin 4 Publications Verification Cinobufagine	Structural Classification Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	Apoptosis
Cinobufagin is an anticancer agent that can be secreted by the Asiatic toad Bufo gargarizans. Cinobufagin induces the cell cycle arrests in the G1 phase or G2/M phase, leading to *apoptosis* in cancer cells. Cinobufagin inhibits tumor growth in melanoma and glioblastoma multiforme xenograft mouse models .

HY-N1986

Cucurbitacin D	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Trichosanthes kirilowii Maxim. Plants Disease Research Fields Cancer	HSP Apoptosis
Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell *apoptosis, exhibiting anti-tumor* and anti-inflammatory effects .

HY-N6623

Malvidin-3-galactoside chloride	Structural Classification Anthocyans Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Reactive Oxygen Species
Malvidin-3-galactoside chloride, an anthocyanin monomer, induces hepatocellular carcinoma (HCC) cells cycle arrest and *apoptosis. Malvidin-3-galactoside chloride inhibits the production and accumulation of ROS. Malvidin-3-galactoside chloride has anti-tumor* function .

HY-N12044

Asparanin A	Structural Classification Polysaccharides Liliaceae Source classification Plants Saccharides Asparagus officinalis L.	Apoptosis
Asparanin A is an apoptosis inducer with anticancer activity. Asparanin A induces cell cycle arrest in the G0/G1 phase through mitochondria and PI3K/AKT signaling pathways, inhibiting cancer cell growth. Asparanin A also demonstrated in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, significantly inhibiting tumor growth .

HY-13062

Daunorubicin hydrochloride 20+ Cited Publications Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces *apoptosis* and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13062A

Daunorubicin Daunomycin; RP 13057; Rubidomycin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Autophagy Bacterial Antibiotic Apoptosis
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces *apoptosis* and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-N6257

Cafestol 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Rubiaceae Diterpenoids Plants Inflammation/Immunology Disease Research Fields Cancer	ERK PGE synthase COX NF-κB Apoptosis Autophagy AP-1 FAK
Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell *apoptosis* and autophagy, which can be used in the study of cancer .

Cat. No.	Product Name	Chemical Structure

HY-10218S

Everolimus-d4
Everolimus-d₄ is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities[1][2].

HY-12678S1

Entrectinib-d8

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .

HY-W654130

Daunorubicin-13C,d3

Daunorubicin- ¹³C,d₃ is ¹³C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-109583S

4-Oxofenretinide-d4

4-Oxofenretinide-d₄ (4-Oxo-4-HPR-d₄) is deuterium labeled 4-Oxofenretinide. 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9 .

HY-W653896

Alternariol-d2

Alternariol-d₂ is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-122272S

Paroxetine-d4

Paroxetine-d₄ (BRL29060-d₄) is deuterium labeled Paroxetine. Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches .

Cat. No.	Product Name		Classification

HY-159519

EGFR/HER2-IN-16		Azide
EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC₅₀=6.15 nM) and HER-2 (IC₅₀=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce *apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor* cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research .

HY-134061

Arecaidine propargyl ester hydrobromide		Alkynes
Arecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors and has the activity of inhibiting tumor cell proliferation. The application of arecaidine propargyl ester hydrobromide has shown that it can reduce the number of ovarian cancer cells in vitro and induce apoptosis and the production of reactive oxygen species (ROS) at specific concentrations. Arecaidine propargyl ester hydrobromide can also arrest cells at the G2/M phase of the cell cycle and increase the percentage of abnormal mitosis. Arecaidine propargyl ester hydrobromide is more sensitizing to ovarian surface epithelial cells with higher M2 receptor levels than to cancer cells. Arecaidine propargyl ester hydrobromide exhibits the effect of lowering arterial blood pressure when interacting with the cardiovascular system in a natural physiological state, indicating its potential pharmacological application .

HY-159147

SIAIS039		Azide
SIAIS039 is an orally active c-ros oncogene 1 (ROS1)-specific PROTAC with DC₅₀s of 154.46 nM, 126.47 nM, 143.69 nM for HCC78 cells, Ba/F3 expressing the CD74-ROS1 fusion and Ba/F3 expressing the SDC4-ROS1 fusion, respectively. SIAIS039 suppresses cell proliferation, induces cell cycle arrest and *apoptosis, and inhibits clonogenicity against ROS1-positive cells. SIAIS039 demonstrates anti-tumour effects against ROS1-driven tumor* growth vivo. SIAIS039 is composed of the ALK inhibitor Brigatinib (HY-12857), a linker EM-12 (HY-138793), and a VHL ligand E3 ubiquitin ligase 1-Butyne (Red: Brigatinib; Blue: VHL ligand; Black: linker) .

Cat. No.	Product Name		Classification

HY-145729A

Danvatirsen sodium AZD9150 sodium		Antisense Oligonucleotides
Danvatirsen sodium is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen sodium binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

HY-W010800

Cholesteryl hemisuccinate		Cholesterol
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic *apoptosis* and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .

HY-115567

5-NIdR 1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole		Nucleosides and their Analogs
5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells *apoptosis* and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model .

HY-145729

Danvatirsen AZD9150		Antisense Oligonucleotides
Danvatirsen is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

HY-148827A

GEM-231 sodium HYBO-165 sodium		Antisense Oligonucleotides
GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

HY-148827

GEM-231 HYBO-165		Antisense Oligonucleotides
GEM231 is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

HY-158828

SSO111 sodium		Antisense Oligonucleotides
SSO111 sodium, a 20mer fully modified antisense oligonucleotide, targets the oncogene?HER2. SSO111 sodium induces exon 15 skipping during splicing, leading to the generation of a novel mRNA transcript that excludes exon 15. SSO111 sodium downregulated HER2 mRNA, which resulted in the inhibition of proliferation and induction of apoptosis in HER2-overexpressing tumor cells.

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