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binding affinity

" in MedChemExpress (MCE) Product Catalog:

527

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-151529
    PBRM1-BD2-IN-2

    		Epigenetic Reader Domain Cancer
    PBRM1-BD2-IN-2 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer .
    PBRM1-BD2-IN-2
  • HY-P99171
    Gevokizumab

    		Interleukin Related Inflammation/Immunology Cancer
    Gevokizumab is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) .
    Gevokizumab
  • HY-P2480
    Histone H1-derived Peptide

    		CDK Others
    Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDK, can be used to detecting CDK1-cyclinB1 enzyme activity .
    Histone H1-derived Peptide
  • HY-103451
    (R,R)-THC

    		Estrogen Receptor/ERR Metabolic Disease
    (R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6 .
    (R,R)-THC
  • HY-P10544
    Humanized anti-tac (HAT) binding peptide

    		Interleukin Related Others
    Humanized anti-tac (HAT) binding peptide is a peptide that can specifically bind to the Fc region of HAT. HAT is a humanized monoclonal antibody against the low affinity p55 subunit of the interleukin IL-2 receptor. Humanized anti-tac (HAT) binding peptide can be used to develop affinity chromatography media to purify specific monoclonal antibodies .
    Humanized anti-tac (HAT) binding peptide
  • HY-103304
    CGRP antagonist 4

    		CGRP Receptor Neurological Disease
    CGRP antagonist 4 is an antagonist of calcitonin gene-related peptide (CGRP) receptor. CGRP antagonist 4 shows the highest affinity for CGRP receptors in the human brain. CGRP antagonist 4 can be used to study the binding properties of non-peptide calcitonin gene-related peptide (CGRP) receptor antagonist (gepants) in rat, pig and human menes .
    CGRP antagonist 4
  • HY-151528
    PBRM1-BD2-IN-1

    		Epigenetic Reader Domain Cancer
    PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer .
    PBRM1-BD2-IN-1
  • HY-P3584
    (Pro3) GIP, human

    (Pro3) Gastric Inhibitory Peptide, human

    		 Insulin Receptor Metabolic Disease
    (Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) is an efficacious, stable and specific human GIP receptor (hGIPR) full agonist. (Pro3) GIP, human has high binding affinity for human GIPR with Ki/ Kd values of 0.90 nM. (Pro3) GIP, human can be used for the research of obesity-related diabetes .
    (Pro3) GIP, human
  • HY-157980
    CDK9-IN-32

    		CDK Cancer
    CDK9-IN-32 (compound 006-3) is a CDK9 inhibitor .
    CDK9-IN-32
  • HY-W012935
    Piperidine-4-carbaldehyde

    Piperidine-4-carboxaldehyde

    		 PROTAC Linkers Cancer
    Piperidine-4-carbaldehyde (Piperidine-4-carboxaldehyde) is a PROTAC Linker. Piperidine-4-carbaldehyde can be used to optimize combined with the target protein affinity, thus improve the PROTAC the molecular degradation efficiency. Piperidine-4-carbaldehyde can be used in the CDK2 PROTACs (HY-161708) .
    Piperidine-4-carbaldehyde
  • HY-100301
    FR167344 free base

    		Bradykinin Receptor Inflammation/Immunology Endocrinology
    FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist. FR167344 free base shows a high affinity binding to the B2 receptor with an IC50 value of 65 nM and no binding affinity for the B1 receptor.
    FR167344 free base
  • HY-P2297
    TfR-T12

    		Transferrin Receptor Metabolic Disease
    TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .
    TfR-T12
  • HY-P2297A
    TfR-T12 TFA

    		Transferrin Receptor Metabolic Disease
    TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .
    TfR-T12 TFA
  • HY-123896
    Calceolarioside A

    		HIV Infection
    Calceolarioside A is phenylethanoid glycoside with moderate binding affinity on HIV gp41 .
    Calceolarioside A
  • HY-101908
    BMS CCR2 22

    		CCR Inflammation/Immunology Endocrinology
    BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM) .
    BMS CCR2 22
  • HY-118124
    2-Iodoestradiol

    		Endogenous Metabolite Others
    2-Iodoestradiol is a potent human sex hormone binding globulin (SHBG) ligand with a remarkably high affinity for SHBG. 2-Iodoestradiol exhibits competition for the same binding site as dihydrotestosterone in binding to human SHBG. The binding affinity constant of 2-Iodoestradiol at physiological pH and 37 degrees Celsius is 2.4 x 10(9) M-1, exceeding that for SHBG. 2-Iodoestradiol has been shown to bind to serum albumin, but with lower affinity. The radioisotope 125I-derivative of 2-Iodoestradiol has been used to study the binding properties of human SHBG, demonstrating its potential application in biological research .
    2-Iodoestradiol
  • HY-151534
    PBRM1-BD2-IN-7

    		Epigenetic Reader Domain Cancer
    PBRM1-BD2-IN-7 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-7 has inhibitory activity for PBRM1-BD2 with an IC50 value of 0.29 μM. PBRM1-BD2-IN-7 can be used for the research of cancer .
    PBRM1-BD2-IN-7
  • HY-159081
    AChE/BChE-IN-20

    		Cholinesterase (ChE) Neurological Disease
    AChE/BChE-IN-20 (compound 3m) is an acetylcholinesterase (AChE, IC50=34.81 µM) and butylcholinesterase (BChE, IC50=20.66 µM) inhibitor, which has been demonstrated to have affinity for key enzyme pockets and favorable interaction profiles by molecular docking and kinetic simulations, and can be used in the study of Alzheimer's disease .
    AChE/BChE-IN-20
  • HY-P3879
    Protein Kinase C (660-673)

    PKC βII (660-673)

    		 PKC Others
    Protein Kinase C (660-673) (PKC βII (660-673)) is the PKC βII V5 peptide with RACK1-binding affinity .
    Protein Kinase C (660-673)
  • HY-P0186
    Endomorphin 2

    		Opioid Receptor Neurological Disease
    Endomorphin 2, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.
    Endomorphin 2
  • HY-107451
    PROTAC BET-binding moiety 1

    		Ligands for Target Protein for PROTAC Cancer
    PROTAC BET-binding moiety 1 is a key intermediate for the synthesis of high-affinity BET inhibitors .
    PROTAC BET-binding moiety 1
  • HY-N5140
    Bacopaside X

    Bacopaside VII

    		 Dopamine Receptor Others
    Bacopaside X is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor .
    Bacopaside X
  • HY-15464D
    (S)-Gossypol (acetic acid)
    5+ Cited Publications

    (S)-(+)-Gossypol acetic acid

    		 Bcl-2 Family Cancer
    (S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
    (S)-Gossypol (acetic acid)
  • HY-P0186A
    Endomorphin 2 TFA

    		Opioid Receptor Neurological Disease
    Endomorphin 2 TFA, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM .
    Endomorphin 2 TFA
  • HY-124467
    Difludiazepam

    Ro 07-4065

    		 GABA Receptor Neurological Disease
    Difludiazepam (Ro 07-4065), a benzodiazepine, has binding affinity (0.613) to GABAA receptors .
    Difludiazepam
  • HY-100155
    4-IBP

    		Sigma Receptor Cancer
    4-IBP is a selective σ1 agonist, binding to σ1 receptors with high affinity (Ki = 1.7 nM) and with slightly weaker affinity to σ2 receptors (Ki = 25.2 nM).
    4-IBP
  • HY-101181
    THK-5105

    		Microtubule/Tubulin Neurological Disease
    THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD)  brain homogenates. 18F-THK-5105 has the potential to act as a tau imaging PET probe .
    THK-5105
  • HY-10830A
    PBPE hydrochloride

    		Estrogen Receptor/ERR Cancer
    PBPE hydrochloride is a derivative of tamoxifen (HY-13757A) and a selective ligand for the anti-estrogen binding site (AEBS), the binding affinities (Ki) of PBPE hydrochloride and MBPE to AEBS are 8.79 and 17.57 nM, respectively .
    PBPE hydrochloride
  • HY-151797
    Ph-HTBA

    		CaMK Neurological Disease
    Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders .
    Ph-HTBA
  • HY-136659
    Ro 04-5595

    		iGluR Others
    Ro 04-5595 is a selective antagonist with specific activity against the NR2B subunit of the NMDA receptor. Ro 04-5595 exhibits favorable pharmacokinetic properties in in vitro and in vivo studies, with rapid uptake and clearance. Ro 04-5595 exhibits strong binding in NR2B receptor-enriched regions and low binding in the cerebellum. Ro 04-5595 is able to effectively inhibit specific binding, showing high affinity for the NR2B receptor and a clear ranking of binding affinity with a variety of other compounds .
    Ro 04-5595
  • HY-P1921
    YRGDS Fibronectin Fragment

    		Integrin Thrombin Cardiovascular Disease
    YRGDS Fibronectin Fragment is a fibronectin fragment, an adhesion peptide that displays strong binding affinity to thrombin-stimulated platelets .
    YRGDS Fibronectin Fragment
  • HY-101182
    THK-5117

    		Microtubule/Tubulin Neurological Disease
    THK-5117, an arylquinoline derivative, displays high binding affinity to tau fibrils with a Ki of 10.5 nM. THK-5117 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD)  brain homogenates. 18F-THK-5117 has the potential to act as a tau imaging PET probe .
    THK-5117
  • HY-155471
    IMP 245

    		Biochemical Assay Reagents Others
    IMP 245 is a symmetric di-HSG bivalent hapten. IMP 245 has low toxicity, high affinity binding to available antibodies and absence of cross reactivity or non-specific binding with body components .
    IMP 245
  • HY-107633
    A 1120
    1 Publications Verification

    		 Transthyretin (TTR) Metabolic Disease
    A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin .
    A 1120
  • HY-121535
    Levosemotiadil

    		Sodium Channel Calcium Channel Others
    Levosemotiadil, an S-isomer of semotiadil, exhibits stronger binding affinity to human serum albumin (HSA) compared to its R-isomer counterpart. This study utilized high-performance frontal analysis (HPFA) to demonstrate that levosemotiadil binds approximately three times more strongly to HSA than semotiadil. The binding parameters were evaluated using Scatchard analysis, revealing specific interactions with the diazepam binding site on HSA. The presence of diazepam decreased the binding affinity of both enantiomers, while warfarin did not alter their binding characteristics. These findings highlight levosemotiadil's potential as a Ca- and Na-channel blocker with significant binding preferences for HSA, crucial for understanding its pharmacokinetics and therapeutic effects .
    Levosemotiadil
  • HY-160057
    GMT 8 aptamer sodium

    		DNA Alkylator/Crosslinker Cancer
    GMT 8 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM .
    GMT 8 aptamer sodium
  • HY-N5068
    Isorhamnetin 7-O-α-L-rhamnoside

    		SARS-CoV Infection
    Isorhamnetin 7-O-α-L-rhamnoside shows binding affinity with COVID-19 virus main protease .
    Isorhamnetin 7-O-α-L-rhamnoside
  • HY-170811
    DCDQ

    		mAChR Neurological Disease
    DCDQ is a potent acetylcholinesterase (AChE) inhibitor. DCDQ shows a strong binding affinity with the 4EY7 protein (binding energy: −8.2 kcal/mol). DCDQ is promising for research of Alzheimer's disease (AD) .
    DCDQ
  • HY-14319B
    Sazetidine A dihydrochloride

    		nAChR Neurological Disease
    Sazetidine A dihydrochloride is a potent ligand for the α4β2 nAChR, with high binding affinity and selectivity for this subtype. Sazetidine A dihydrochloride exhibits favorable pharmacological properties and may contribute to research targeting nicotinic receptor-related diseases. Sazetidine A dihydrochloride has been mentioned in studies investigating the binding affinity of various analogs, highlighting its importance in understanding the nAChR ligand subtype selectivity .
    Sazetidine A dihydrochloride
  • HY-B1844
    Flucythrinate

    		Endogenous Metabolite Cancer
    Flucythrinate is a synthetic pyrethroid with endocrine suppressive properties. Flucythrinate showed good binding affinity to the vitamin D nuclear receptor (VDR) with a score of -11.0 kcal/mol. Flucythrinate has been proposed as a multi-target ligand that may interact with several proteins associated with breast cancer. The screening method for Flucythrinate showed good accuracy in binding site prediction and affinity estimation .
    Flucythrinate
  • HY-P1377
    Caffeic acid-pYEEIE

    		Src Inflammation/Immunology
    Caffeic acid-pYEEIE, a non-phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain .
    Caffeic acid-pYEEIE
  • HY-P10800
    T20-M

    		Deubiquitinase Cancer
    T20-M is a lead peptide that shows good potential for binding affinity towards UBE2C .
    T20-M
  • HY-112156
    MS4077

    		PROTACs Anaplastic lymphoma kinase (ALK) Cancer
    MS4077 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 37?nM for binding affinity to ALK .
    MS4077
  • HY-112155
    MS4078
    2 Publications Verification

    		 PROTACs Anaplastic lymphoma kinase (ALK) Cancer
    MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19?nM for binding affinity to ALK .
    MS4078
  • HY-P3152
    Streptavidin
    2 Publications Verification

    		 Biochemical Assay Reagents Others
    Streptavidin is a ～60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ～ 0.01 pM . Streptavidin has an immunosuppressive role .
    Streptavidin
  • HY-18668
    Integrin antagonist 27

    		Integrin Cancer
    Integrin antagonist 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.
    Integrin antagonist 27
  • HY-126829
    Coumarin-SAHA

    		HDAC Cancer
    Coumarin-SAHA is a fluorescent probe for determining the binding affinities (kd) and the dissociation off-rates (koff) of the HDAC8-inhibitor complexes .
    Coumarin-SAHA
  • HY-P1377A
    Caffeic acid-pYEEIE TFA

    		Src Inflammation/Immunology
    Caffeic acid-pYEEIE TFA, a non-phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain .
    Caffeic acid-pYEEIE TFA
  • HY-114872
    SLF

    		Ligands for Target Protein for PROTAC FKBP Cancer
    SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC .
    SLF
  • HY-P0185
    Endomorphin 1
    2 Publications Verification

    		 Opioid Receptor Neurological Disease
    Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (Ki: 1.11 nM), displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties .
    Endomorphin 1

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