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Results for "

CYPs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cytochrome P450 (551) 11β-HSD (1) 5-HT Receptor (25) Acetolactate Synthase (ALS) (1) Adenosine Receptor (2) Adrenergic Receptor (16) Akt (2) Aldose Reductase (1) AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (9) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (30) Apical Sodium-Dependent Bile Acid Transporter (1) Apoptosis (35) Aryl Hydrocarbon Receptor (19) Atg8/LC3 (1) Autophagy (56) Bacterial (45) Bcl-2 Family (2) Bcr-Abl (1) Biochemical Assay Reagents (6) Bradykinin Receptor (1) Btk (2) c-Kit (2) c-Met/HGFR (7) Calcium Channel (17) CaMK (1) Cannabinoid Receptor (3) Caspase (5) CaSR (2) Cathepsin (2) CCR (2) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (9) Constitutive Androstane Receptor (3) COX (16) CRFR (1) CXCR (4) Cyclophilin (2) Dihydrofolate reductase (DHFR) (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (4) Dopamine Receptor (10) Dopamine β-hydroxylase (2) Drug Intermediate (4) Drug Isomer (1) Drug Metabolite (66) E3 Ligase Ligand-Linker Conjugates (1) EGFR (6) Endogenous Metabolite (51) Enterovirus (1) Epigenetic Reader Domain (1) ERK (4) Estrogen Receptor/ERR (3) Factor Xa (1) FAK (1) Ferroptosis (6) FGFR (2) Filovirus (2) FLT3 (4) Fluorescent Dye (5) FOXO (1) Fungal (72) FXR (2) GABA Receptor (7) Glucocorticoid Receptor (6) Glutathione Peroxidase (1) Glutathione S-transferase (2) GnRH Receptor (1) GPR119 (1) HBV (8) HCV (6) HCV Protease (5) HDAC (2) Heme Oxygenase (HO) (1) Histamine Receptor (8) Histone Demethylase (1) HIV (26) HIV Integrase (3) HIV Protease (9) HMG-CoA Reductase (HMGCR) (1) HSP (1) HSV (1) IDE (1) iGluR (5) IKK (2) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (10) Insecticide (3) Interleukin Related (3) IPK Superfamily (1) Isotope-Labeled Compounds (73) JAK (3) Keap1-Nrf2 (3) Lactate Dehydrogenase (1) Leukotriene Receptor (1) Ligands for Target Protein for PROTAC (2) Liposome (1) Lipoxygenase (1) LRRK2 (2) LXR (2) mAChR (5) MCHR1 (GPR24) (2) MDM-2/p53 (3) MEK (2) mGluR (1) Mineralocorticoid Receptor (5) Mitosis (1) Mixed Lineage Kinase (1) Monoamine Oxidase (6) Monocarboxylate Transporter (1) mTOR (2) nAChR (2) NAMPT (2) Necroptosis (3) Neurokinin Receptor (6) NF-κB (8) NO Synthase (7) Notch (1) Nuclear Factor of activated T Cells (NFAT) (1) Opioid Receptor (2) P-glycoprotein (25) P2Y Receptor (3) p38 MAPK (2) p62 (1) Parasite (24) PARP (1) PD-1/PD-L1 (4) PERK (1) Phospholipase (8) Phytohormone (1) PI3K (1) PKC (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (20) PPAR (20) Pregnane X Receptor (PXR) (1) Prostaglandin Receptor (1) PROTAC Linkers (1) PROTACs (2) Proteolytic Enzyme (1) Proton Pump (11) Pyruvate Kinase (1) Quinone Reductase (1) Raf (2) RAR/RXR (7) Ras (6) Reactive Oxygen Species (ROS) (8) Reference Standards (114) Reverse Transcriptase (8) Ribosomal S6 Kinase (RSK) (1) ROCK (1) ROR (2) ROS Kinase (2) SARS-CoV (15) Serotonin Transporter (2) SGLT (1) Sigma Receptor (2) Sirtuin (1) Small Interfering RNA (siRNA) (88) SOD (2) Sodium Channel (12) SOS1 (1) STAT (5) Telomerase (2) Thrombopoietin Receptor (7) Thyroid Hormone Receptor (3) Toll-like Receptor (TLR) (3) Topoisomerase (5) URAT1 (2) Urotensin Receptor (1) VD/VDR (1) VEGFR (4) Virus Protease (4) VKOR (1) Xanthine Oxidase (3) α-synuclein (1) β-catenin (1) γ-secretase (2)
By Research Areas:	Cancer (307) Cardiovascular Disease (89) Endocrinology (31) Infection (184) Inflammation/Immunology (140) Metabolic Disease (206) Neurological Disease (127)
Click Chemistry:	Alkynes (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (17) Mouse Pre-designed siRNA Sets (16) Human Pre-designed siRNA Sets (54) siRNAs (87)

982

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

162

Natural
Products

110

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Cytochrome P450

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116862

Dibenzylfluorescein DBF	Cytochrome P450 Fluorescent Dye	Others
Dibenzylfluorescein (DBF) is a fluorogenic probe (Fluoresecent dye) that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). Dibenzylfluorescein is typically used near its K_m value of 0.87-1.9 μM (Ex=485 nm，Em=535 nm). Dibenzylfluorescein is used to detect changes in *CYP* catalytic activity caused by drugs or disease .

HY-129993

Gemfibrozil 1-O-β-glucuronide	PPAR Cytochrome P450 Drug Metabolite	Cardiovascular Disease Metabolic Disease
Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC₅₀ of 4.07 μM .

HY-156330

HIV-IN-9	HIV Cytochrome P450	Infection
HIV-IN-9 (Compound 2b) is a HIV inhibitor (IC₅₀: 6.65 μg/mL), and has high binding affinity with HIV-RT. HIV-IN-9 also inhibits CYP3A4, CYP1A2, CYP2C1, and CYP2D6 .

HY-149769

CP-506	Cytochrome P450	Cancer
CP-506 (compound 26) is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity .

HY-149769A

CP-506 mesylate	Cytochrome P450	Cancer
CP-506 (compound 26) mesylate is an anticancer compound and a substrate for nitroreductase and CYP oxidoreductases. CP-506 has anticancer activity .

HY-158623

(±)13(14)-DiHDPA (±)13,14-DiHDPE	Drug Metabolite	Inflammation/Immunology
(±)13(14)-DiHDPA ((±)13,14-DiHDPE) a metabolite of Docosahexaenoic acid (DHA; HY-B2167) by P450 (CYP) metabolic pathways .

HY-N8094

Kushenol M	Cytochrome P450	Others
Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC₅₀ values of 1.29 μM for CYP3A4 in human liver microsomes .

HY-N4205R

Tetrahydropiperine (Standard)	Reference Standards Cytochrome P450	Cancer
Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .

HY-13600S1

Clobetasol propionate-d5	Isotope-Labeled Compounds Cytochrome P450	Inflammation/Immunology
Clobetasol propionate-d₅ is a deuterium substitute of Clobetasol propionate. Clobetasol propionate is a potent, selective *CYP3A5* inhibitor with a IC₅₀ of 0.206 μM and has potential for use in the study of psoriasis and other skin diseases .

HY-163415

MAO-IN-5	Monoamine Oxidase	Neurological Disease
MAO-IN-5 (Compound ZINC000016952895) is a monoamine oxidase (MAO) inhibitor. According to the prediction of Swiss ADME, MAO-IN-5 can inhibit the CYP enzyme family, has blood-brain barrier (BBB) permeability, and has a high gastrointestinal absorption rate. MAO-IN-5 can be used in the study of neurological diseases .

HY-W267897

7-Benzyloxy-4-(trifluoromethyl)coumarin 7-BFC	Cytochrome P450	Others
7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies .

HY-143906

URAT1 inhibitor 2	URAT1	Inflammation/Immunology
URAT1 inhibitor 2 is an orally active and potent URAT1 and CYP isozyme inhibitor, with IC₅₀ values of 1.36 μM, 16.97 μM, 5.22 μM for URAT1-mediated ¹⁴C-UA uptake, CYP1A2 and CYP2C9, respectively. URAT1 inhibitor 2 is a promising agent candidate in the study of hyperuricemia and gout .

HY-125068

RPR203494	Cytochrome P450 p38 MAPK	Inflammation/Immunology
RPR203494 is a potent inhibitor against CYP isozymes. RPR203494 shows inhibition against p38 kinase with an IC₅₀ value of 9 nM and an EC₅₀ value of 60 nM. RPR203494 demonstrates an inhibition of hepatic Cytochrome P450. RPR203494 is promising for research of rheumatoid arthritis (RA) .

HY-W196803

Dipropyl disulfide Propyl Disulfide; DPDS	Cytochrome P450	Others
Dipropyl disulfide is oxidized to dipropyl thiosulfinate (DPDSO) by rat microsomes. Both flavincontaining monooxygenases (FMO) and cytochrome P450 enzymes (CYPs) are involved in dipropyl disulfide oxidation. Dipropyl disulfide forms two metabolites: propylglutathione sulfide conjugate and propylthiol .

HY-144286

CXCR4 antagonist 3	CXCR	Infection
CXCR4 antagonist 3 (compound 12a) is a potent antagonist of CXCR4 with an IC₅₀ of 11 nM. CXCR4 antagonist 3 is a congener of TIQ15. CXCR4 antagonist 3 demonstrates the best overall properties including CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. CXCR4 antagonist 3 has the potential for the research of human immunodeficiency virus .

HY-B0189

Mosapride 4 Publications Verification TAK-370; AS-4370	5-HT Receptor Cytochrome P450 Potassium Channel	Neurological Disease Cancer
Mosapride is an orally active gastroenterokinetic compound. Mosapride is a 5HT4 agonist. Mosapride is a *CYP* inducer. Mosapride has a concentration-dependent inhibitory effect on Kv4.3, and its IC₅₀ value is 15.2 μM. Mosapride can be used in the study of gastrointestinal diseases .

HY-B0189A

Mosapride citrate 4 Publications Verification TAK-370 citrate; AS-4370 citrate	5-HT Receptor Potassium Channel Cytochrome P450	Neurological Disease Cancer
Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4 agonist. Mosapride citrate is a *CYP* inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC₅₀ value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases .

HY-13269

BMS-707035 1 Publications Verification	HIV HIV Integrase	Infection Inflammation/Immunology
BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC₅₀ value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) .

HY-146410

AT2R antagonist 1	Angiotensin Receptor	Others
AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a K_i of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes .

HY-N8382

Chalepensin	Cytochrome P450	Neurological Disease
Chalepensin, a furanocoumarin, is a competitive *CYP2A6* inhibitor. Chalepensin also inhibits human CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4 to different extents .

HY-151253

CYP2C1/CYP2C19-IN-2	Cytochrome P450 Virus Protease	Infection
CYP2C1/CYP2C19-IN-2 (compound 21d) is a potent *CYP2C9/CYP2C19* inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C1/CYP2C19-IN-2 can be used in study of anti-ZIKV .

HY-151251

CYP2C9/CYP2C19-IN-1	Cytochrome P450 Virus Protease	Infection
CYP2C9/CYP2C19-IN-1 (compound 22d) is a potent *CYP2C9/CYP2C19* inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C9/CYP2C19-IN-1 can be used in study of anti-ZIKV .

HY-151809

CYP4A11/CYP4F2-IN-1	Cytochrome P450	Metabolic Disease
CYP4A11/CYP4F2-IN-1 is a potent dual inhibitor of *cytochrome P450 (CYP) 4A11* and *CYP4F2, with IC₅₀s of 19 nM and 17 nM, respectively. CYP4A11/CYP*4F2-IN-1 has potential for the research of renal diseases .

HY-Y0110

2-Naphthol	Endogenous Metabolite	Others
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-176210

CYP51-IN-24	Fungal Cytochrome P450	Infection
CYP51-IN-24 (Compound 22) is a Sterol 14α-Demethylase (CYP51) inhibitor. CYP51-IN-24 exhibits potent inhibitory activity against wild-type and drug-resistant fungi. CYP51-IN-24 inhibits ergosterol biosynthesis by binding to the fungal CYP51 enzyme. CYP51-IN-24 can be used in research and drug development against drug-resistant fungal infections .

HY-151810

TP0472993	Cytochrome P450	Metabolic Disease
CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of *cytochrome P450 (CYP) 4A11* and *CYP4F2, with IC₅₀s of 140 nM and 40 nM, respectively. CYP4A11/CYP*4F2-IN-2 has potential for the research of renal diseases .

HY-155493

CYP19A1/CYP11B2-IN-1	Cytochrome P450	Cancer
CYP19A1/CYP11B2-IN-1 (Compound X21) is a potent and selective aromatase and aldosterone synthase dual inhibitor with IC₅₀s of 2.3 nM and 29 nM for aromatase (CYP19A1) and aldosterone synthase (CYP11B2), respectively. CYP19A1/CYP11B2-IN-1 has excellent antiproliferative and pro-apoptotic activity against the cancer cell. CYP19A1/CYP11B2-IN-1 can be used for research of breast cancer .

HY-168188

CYP51-IN-21	Cytochrome P450	Infection
CYP51-IN-21 (Compound A33) is a potent *CYP51* inhibitor. CYP51-IN-21 shows excellent antifungal activities against pathogenic fungi and drug-resistant strains. CYP51-IN-21 inhibits the formation of fungal biofilm .

HY-N2181A

DL-Acetylshikonin	Cytochrome P450	Inflammation/Immunology Cancer
DL-Acetylshikonin is a non-selective, reversible cytochrome P450 inhibitor with IC₅₀ values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities .

HY-152079

CYP1B1-IN-3	Cytochrome P450	Cancer
CYP1B1-IN-3 is a potent and selective *CYP1B1* inhibitor with IC₅₀ values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways .

HY-W082430

CYP2A6-IN-2	Cytochrome P450	Neurological Disease
CYP2A6-IN-2 (compound 5) is a *CYP2A6* inhibitor. CYP2A6-IN-2 can be used in the study of nicotine dependence .

HY-162370

CYP51-IN-16	Cytochrome P450	Infection Cancer
CYP51-IN-16 (compound C6) is a phenylpyrimidine *CYP51* inhibitor, and shows antifungal activity in in vitro. CYP51-IN-16 inhibits tumor cell growth .

HY-135281

CYP11B2-IN-1	Cytochrome P450	Cardiovascular Disease
CYP11B2-IN-1 is a *CYP11B2* inhibitor with an IC₅₀ of 2.3 nM. CYP11B2-IN-1 inhibits CYP11B1 with an IC₅₀ of 142 nM .

HY-173279

CYP19A1-IN-1	Cytochrome P450	Endocrinology
CYP19A1-IN-1 (Compound 9) is a *CYP19A1* inhibitor with an IC₅₀ of 271 nM. CYP19A1-IN-1 inhibits the activity of converting androgens to estrogens by binding to *CYP19A1. CYP*19A1-IN-1 can be used in the research of sex hormone-related diseases such as estrogen-dependent breast cancer .

HY-144643

CYP51/HDAC-IN-1	Fungal HDAC Cytochrome P450	Inflammation/Immunology
CYP51/HDAC-IN-1 is a potent, orally active *CYP51/HDAC* dual inhibitor. CYP51/HDAC-IN-1 inhibits important virulence factors and down-regulated resistance-associated genes. CYP51/HDAC-IN-1 exhibits potent therapeutic effects for both tropical candidiasis and cryptococcal meningitis .

HY-162784

CYP51-IN-19	Fungal Cytochrome P450	Infection
CYP51-IN-19 (compound C07) is a potent *CYP51* inhibitor. CYP51-IN-19 stimulates reactive oxygen species (ROS) and exhibits potent fungicidal activity .

HY-149770

CYP4A11/CYP4F2-IN-2	Cytochrome P450	Metabolic Disease
CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC₅₀s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease .

HY-W013268

(S)-(+)-N-3-Benzylnirvanol (+)-N-3-Benzylnirvanol	Cytochrome P450	Metabolic Disease
(S)-(+)-N-3-Benzylnirvanol ((+)-N-3-Benzylnirvanol) is a selective and competitive cytochrome P450 (CYP) isoform *CYP2C19* inhibitor with a K_i of 250 nM. (S)-(+)-N-3-Benzylnirvanol has low activity against CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, and CYP3A4 .

HY-13269R

BMS-707035 (Standard)	HIV HIV Integrase	Infection Inflammation/Immunology
BMS-707035 (Standard) is the analytical standard of BMS-707035. This product is intended for research and analytical applications. BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC50 value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) .

HY-E70476

*Human CYP1B1,Low-Reductase*	Cytochrome P450	Metabolic Disease
Human CYP1B1, Low-Reductase, a recombinant CYP1B1, is a member of the CYP enzyme family. CYP1B1 is constitutively expressed at some extrahepatic tissues, metabolizes a variety of the same, mostly planar, substrates for CYP1A1 and CYP1A2 .

HY-176480

CYP11B2-IN-3	Cytochrome P450	Cardiovascular Disease
CYP11B2-IN-3 (compound 32) is an orally active and selective *CYP11B2* inhibitor with IC₅₀ values of 12.92 nM and 2341 nM for CYP11B2 and CYP11B1, respectively. CYP11B2-IN-3 can be used for study of hypertension .

HY-159585

CYP51-IN-20	Cytochrome P450 Fungal	Infection
CYP51-IN-20 (compound 5b) is an inhibitor of *CYP51* and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on Candida albicans ATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole (HY-76200) to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model .

HY-E70491

*Human CYP3A5,High-Reductase*	Cytochrome P450	Metabolic Disease
Human CYP3A5, High-Reductase, a recombinant CYP3A5, is a member of the CYP enzyme family. CYP3A5 is mainly expressed in the prostate and the liver .

HY-E70469

*Human CYP3A5,Low-Reductase*	Cytochrome P450	Metabolic Disease
Human CYP3A5, Low-Reductase, a recombinant CYP3A5, is a member of the CYP enzyme family. CYP3A5 is mainly expressed in the prostate and the liver .

HY-170816

CYP51/Hsp90-IN-1	HSP Cytochrome P450 Fungal	Infection
CYP51/Hsp90-IN-1 (Compound MM4) is a dual *CYP51/Hsp90* inhibitor. CYP51/Hsp90-IN-1 shows antifungal activity against Candida albicans and effectively inhibits important fungal virulence factors. CYP51/Hsp90-IN-1 is promising for research of invasive candidiasis .

HY-18642

CYP3cide PF-4981517	Cytochrome P450	Others
CYP3cide (PF-4981517) is a potent, selective and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC₅₀ values for Midazolam 1’-hydroxylase activity are 0.03 μM, 17 μM, and 71 μM for *CYP3A4, CYP3A5, and CYP3A7, respectively. CYP3cide can be used to distinguish the contributions of CYP3A4* versus CYP3A5 on agent metabolism .

HY-157170

CYP450-IN-1	Cytochrome P450	Cancer
CYP450-IN-1 (compound 2e) is a potent inhibitor of *CYP450* .

HY-B2015

Carbosulfan	Cytochrome P450 Parasite	Infection
Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers).

HY-Y0110S

2-Naphthol-d8	Endogenous Metabolite	Others
2-Naphthol-d₈ is the deuterium labeled 2-Naphthol . 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-Y0110S1

2-Naphthol-d7	Endogenous Metabolite	Others
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol . 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

Cat. No.	Product Name

HY-L922

MCE Good ADMET Diversity Library

25000 compounds

A diverse compound library with favorable ADMET properties (Absorption, Distribution, Metabolism, Excretion, and Toxicity) is crucial in drug discovery. Early evaluation of ADMET properties allows for the exclusion of molecules with unfavorable profiles at the initial stages, thereby reducing the risk of late-stage development failures, lowering R&D costs, and accelerating optimization of lead compounds. Based on predictions from ADMET-related AI algorithms, the compounds in this library are predicted to exhibit favorable oral bioavailability (F > 30%), reasonable plasma protein binding (PPB < 98%), minimized CYP3A4 inhibition potential (inhibition probability < 50%, CYP3A4 is the most critical drug-metabolizing enzyme in the cytochrome P450 family) , low toxicity profiles, with 140 potentially toxic substructures pre-identified and excluded via substructure searching to eliminate compounds containing hazardous fragments. The diversity library enables broad applicability in high-throughput screening (HTS) and high-content screening (HCS).

Cat. No.	Product Name	Type

HY-116862

Dibenzylfluorescein

DBF

Fluorescent Dyes/Probes

Dibenzylfluorescein (DBF) is a fluorogenic probe (Fluoresecent dye) that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). Dibenzylfluorescein is typically used near its K_m value of 0.87-1.9 μM (Ex=485 nm，Em=535 nm). Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease .

HY-W027773

7-Methoxy-4-(trifluoromethyl)coumarin MFC	Fluorescent Dyes/Probes
7-Methoxy-4-(trifluoromethyl)coumarin (MFC) is a fluorescent substrate for cytochrome P450 and can quantify CYP activity .

HY-D0144

Resorufin methyl ether Methoxyresorufin	Chromogenic Substrates
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate . Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents .

HY-D0145

7-Ethoxyresorufin 1 Publications Verification Resorufin ethyl ether	Chromogenic Substrates
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially *CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase* .

HY-W271064

1-Methylpyrene	Fluorescent Dyes/Probes
1-Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen. Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase (SULT) enzymes. 1-Methylpyrene induces chromosome loss and mitotic disturbance, proba

HY-D0932

Sudan IV

Solvent Red 24; C.I. 26105

Dyes

Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections .

HY-162051

CYP1B1-IN-6	Fluorescent Dyes/Probes
CYP1B1-IN-6 (compound 19) is a fluorescence molecular probes which inhibits *CYP1B1* activity. CYP1B1-IN-6 can identify tumor sites in fluorescence imaging and photoacoustic imaging modes .

HY-17356G

Fenofibrate (GMP)

Fluorescent Dye

Fenofibrate (GMP) is Fenofibrate (HY-17356) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

HY-D0932R

Sudan IV (Standard)

Solvent Red 24 (Standard); C.I. 26105 (Standard)

Dyes

Sudan IV (Standard) (Solvent Red 24 (Standard)) is the analytical standard of Sudan IV (HY-D0932). This product is intended for research and analytical applications. Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.

HY-D0146

Resorufin benzyl ether BzRes; 7-Benzyloxyresorufin; 7-Benzyloxyphenoxazone	Dyes
Resorufin benzyl ether (BzRes), a fluorogenic enzyme substrate, can be used to detect CYP3A4 enzyme activity. Resorufin benzyl ether modified with a recognizing moiety boronate, can be used for ONOO ^- detection via a self-immolation mechanism. Ex/Em=530-570 nm/590 nm .

Cat. No.	Product Name	Type

HY-W008003

2-Hydroxybenzimidazole	Biochemical Assay Reagents
2-Hydroxybenzimidazole is an inactive compound targeting *CYP1A1* and is mainly used as a control compound in the structure-activity relationship study of benzimidazole derivatives. 2-Hydroxybenzimidazole does not have the ability to induce CYP1A1 expression like its thiol or amino substituted derivatives .

HY-D0848

N,N'-Methylenebisacrylamide

Bisacrylamide; MBA; Methylenebisacrylamide; N,N-Methylenebisacrylamide

Thickeners

N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel .

HY-17356G

Fenofibrate (GMP)

Biochemical Assay Reagents

HY-N9934R

(-)-3-Dehydroshikimic acid (Standard) 3-DHS (Standard); 5-Dehydroshikimic acid (Standard)	Biochemical Assay Reagents
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

Cat. No.	Product Name	Target	Research Area

HY-144285

CXCR4 antagonist 4	CXCR HIV	Inflammation/Immunology
CXCR4 antagonist 4 is a potent, orally active CXCR4 antagonist (IC₅₀=24 nM) with diminished CYP 2D6 activity, improved PAMPA permeability, potent inhibition of human immunodeficiency virus entry (IC₅₀=7 nM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8382

Chalepensin	Structural Classification Natural Products Haloxylon ammodendron (C. A. Mey.) Bunge Source classification Amaranthaceae Plants	Cytochrome P450
Chalepensin, a furanocoumarin, is a competitive *CYP2A6* inhibitor. Chalepensin also inhibits human CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4 to different extents .

HY-Y0110

2-Naphthol	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-N0482

Phillyrin 5 Publications Verification	Infection Structural Classification Oleaceae Classification of Application Fields Source classification Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields	Cytochrome P450 Influenza Virus Bacterial
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat *CYP1A2* and *CYP2D1* activities, without affecting CYP2C11 and CYP3A1/2 activities . Phillyrin has anti-influenza A virus activities .

HY-158623

(±)13(14)-DiHDPA (±)13,14-DiHDPE	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Drug Metabolite
(±)13(14)-DiHDPA ((±)13,14-DiHDPE) a metabolite of Docosahexaenoic acid (DHA; HY-B2167) by P450 (CYP) metabolic pathways .

HY-N8094

Kushenol M	Flavanonols Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields	Cytochrome P450
Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC₅₀ values of 1.29 μM for CYP3A4 in human liver microsomes .

HY-N4205R

Tetrahydropiperine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Piperaceae Plants Piper nigrum Linn.	Reference Standards Cytochrome P450
Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .

HY-N2181A

DL-Acetylshikonin	Quinones Structural Classification Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae	Cytochrome P450
DL-Acetylshikonin is a non-selective, reversible cytochrome P450 inhibitor with IC₅₀ values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities .

HY-Y0110R

2-Naphthol (Standard)	Structural Classification Monophenols Microorganisms Source classification Phenols Endogenous metabolite	Reference Standards Endogenous Metabolite
2-Naphthol (Standard) is the analytical standard of 2-Naphthol. This product is intended for research and analytical applications. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-N6023

Thermopsoside	Flavonoids Classification of Application Fields Flavones Astragalus microcephalus Willd. Source classification Other Diseases Phenols Polyphenols Plants Compositae Disease Research Fields	Cytochrome P450
Thermopsoside is a flavone derivative isolated from Aspalathus linearis. Thermopsoside exhibits inhibitory effects on CYP450 isozymes with IC₅₀ values of 6.0 μM, 9.5 μM, 12.0 μM, 32.0 μM, for CYP3A4, CYP2C19, CYP2D6 and CYP2C9, respectively .

HY-113482

1β-Hydroxydeoxycholic acid 1β-OH-DCA	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite Cytochrome P450
1β-Hydroxydeoxycholic acid (1β-OH-DCA), a secondary bile acid, is a CYP3A biomarker. Deoxycholic acid is specifically metabolized into 1β-Hydroxydeoxycholic acid by CYP3A4 and CYP3A7 using recombinant human CYP450 enzymes .

HY-N0453

Hypericin 4 Publications Verification	Structural Classification Natural Products Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Hyperlcurn perforatum L. Plants Disease Research Fields Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-N0319

Salvianolic acid C 3 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Cytochrome P450
Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with K_is of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

HY-N0482R

Phillyrin (Standard)	Structural Classification Oleaceae Source classification Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants	Reference Standards Cytochrome P450 Influenza Virus Bacterial
Phillyrin (Standard) is the analytical standard of Phillyrin. This product is intended for research and analytical applications. Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities . Phillyrin has anti-influenza A virus activities .

HY-N3090

Peucedanol	Structural Classification Carpesium cernuum L. Source classification Coumarins Phenylpropanoids Plants Umbelliferae	Cytochrome P450
Peucedanol is a non-competitive inhibitor of *CYP3A4* with a K_i value of 4.07 μM and a competitive inhibitor of *CYP1A2* and *CYP2D6* with K_i values of 3.39 μM and 6.77 μM, respectively .

HY-N5132

(-)-Fenchone	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Umbelliferae Plants Vernonia Schreb. Disease Research Fields	Others
(-)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Foeniculum vulgare. (-)-Fenchone is oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives by CYP2A6 and CYP2B6 in human liver microsomes with CYP2A6 playing a more important role than CYP2B6 .

HY-N0893

Tetrahydrocurcumin 2 Publications Verification HZIV 81-2	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Microorganisms Phenols Polyphenols Curcuma longa Inflammation/Immunology Disease Research Fields Zingiberaceae Cancer	Cytochrome P450 Autophagy Endogenous Metabolite
Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit *CYP2C9* and *CYP3A4*.

HY-N0319R

Salvianolic acid C (Standard)	Structural Classification Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Plants	Reference Standards Cytochrome P450
Salvianolic acid C (Standard) is the analytical standard of Salvianolic acid C. This product is intended for research and analytical applications. Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

HY-N5132R

(-)-Fenchone (Standard)	Structural Classification Other Monoterpenes Terpenoids Source classification Umbelliferae Plants Vernonia Schreb.	Reference Standards Others
(-)-Fenchone (Standard) is the analytical standard of (-)-Fenchone. This product is intended for research and analytical applications. (-)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Foeniculum vulgare. (-)-Fenchone is oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives by CYP2A6 and CYP2B6 in human liver microsomes with CYP2A6 playing a more important role than CYP2B6 .

HY-N0598

Ginsenoside F1 20(S)-Ginsenoside F1	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Cytochrome P450 Endogenous Metabolite
Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of *CYP3A4* activity and weaker inhibition of CYP2D6 activity.

HY-N7266

Obtusifoliol	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Sorghum bicolor (Linn.) Moench Microorganisms Classification of Application Fields Gramineae Source classification Plants Endogenous metabolite Disease Research Fields	Cytochrome P450 Parasite
Obtusifoliol is a specific *CYP51* inhibitor, Obtusifoliol shows the affinity with K_d values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively .

HY-I0736

Isonicotinic acid	Alkaloids Aloe africana Liliaceae Source classification Other Diseases Pyridine Alkaloids Plants Disease Research Fields	Drug Metabolite Endogenous Metabolite
Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-N0893R

Tetrahydrocurcumin (Standard) HZIV 81-2 (Standard)	Structural Classification Microorganisms Source classification Phenols Polyphenols Plants Curcuma longa Endogenous metabolite Zingiberaceae	Reference Standards Cytochrome P450 Autophagy Endogenous Metabolite
Tetrahydrocurcumin (Standard) is the analytical standard of Tetrahydrocurcumin. This product is intended for research and analytical applications. Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.

HY-133091

7-Ethoxycoumarin 7-O-Ethylumbelliferone	Structural Classification Citrus × aurantium Linnaeus Classification of Application Fields Source classification Rutaceae Other Diseases Coumarins Phenylpropanoids Plants Disease Research Fields	Cytochrome P450
7-Ethoxycoumarin is a substrate of cytochrome P450 (CYP450). 7-Ethoxycoumarin has been used for the functional characterization of various CYPs and for the generation of 7-hydroxycoumarin (HY-N0573) .

HY-122410

Dihydrolanosterol 1 Publications Verification	Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Cytochrome P450
Dihydrolanosterol is a subtrate of CYP51 and a cholesterol biosynthesis inhibitor. .

HY-30152

Xanthotoxol 2 Publications Verification 8-Hydroxypsoralen	Structural Classification Monophenols other families Source classification Coumarins Phenols Phenylpropanoids Plants Endogenous metabolite	5-HT Receptor Reactive Oxygen Species (ROS) Endogenous Metabolite
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.

HY-N1407

Polygalaxanthone III	Structural Classification Xanthones Classification of Application Fields Source classification Polygalaceae Phenols Polyphenols Plants Polygala tenuifolia Willd. Inflammation/Immunology Disease Research Fields	Cytochrome P450
Polygalaxanthone III is extracted from polygala tenuifolia wild, has inhibitory effect towards *CYP450* enzyme. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC₅₀ of 50.56 μM .

HY-N0043

Ginsenoside Rd 1 Publications Verification Gypenoside VIII	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca ²⁺ influx. Ginsenoside Rd inhibits *CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀*s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-N0922

Methysticin DL-Methysticin; (±)-Methystici	Structural Classification Natural Products other families Source classification Plants	Cytochrome P450
Methysticin is a major kavalactone in kava extract to induce *CYP1A1*.

HY-N2194

Bergamottin 5+ Cited Publications 5-Geranoxypsoralen; Bergamotine; Bergaptin	Structural Classification Classification of Application Fields Citrus limon (L.) Burm. F. Source classification Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Cytochrome P450
Bergamottin is a potent and competitive *CYP1A1* inhibitor with a K_i of 10.703 nM.

HY-N0920

Dihydrokavain 7,8-Dihydrokawain; 7,8-Dihydrokavain; Marindinin	Structural Classification Natural Products other families Source classification Plants	COX Cytochrome P450
Dihydrokavain (7,8-Dihydrokawain) is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, *CYP2C9* (IC₅₀ = 130.95 μM), CYP2C19 (IC₅₀ = 10.05 μM) and CYP3A4 (IC₅₀ = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects .

HY-I0736R

Isonicotinic acid (Standard)	Alkaloids Aloe africana Liliaceae Source classification Pyridine Alkaloids Plants	Reference Standards Drug Metabolite Endogenous Metabolite
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-N9934R

(-)-3-Dehydroshikimic acid (Standard) 3-DHS (Standard); 5-Dehydroshikimic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Drug Intermediate Reference Standards
Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-N2260

Cephaeline dihydrochloride 1 Publications Verification (-)-Cephaeline dihydrochloride; NSC 32944	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Cytochrome P450
Cephaeline dihydrochloride is a selective *CYP2D6* inhibtor with an IC₅₀ of 121 μM.

HY-W010195

2,6-Dimethylquinoline	Alkaloids Structural Classification Chrysanthemum × morifolium (Ramat.) Hemsl. Classification of Application Fields Source classification Other Diseases Quinoline Alkaloids Umbelliferae Plants Disease Research Fields	Cytochrome P450
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a *CYP1A2* inhibitor with an IC₅₀ of 3.3 µM. 2,6-Dimethylquinoline also inhibits *CYP2B6* activity with an IC₅₀ of 480 µM .

HY-18569AR

3-Indoleacetic acid sodium (Standard) Indole-3-acetic acid sodium (Standard); 3-IAA sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Ginsenoside F1 (Standard) is the analytical standard of Ginsenoside F1. This product is intended for research and analytical applications. Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.

HY-N0598R

Ginsenoside F1 (Standard) 20(S)-Ginsenoside F1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Endogenous metabolite Araliaceae	Reference Standards Cytochrome P450 Endogenous Metabolite
Ginsenoside F1 (Standard) is the analytical standard of Ginsenoside F1. This product is intended for research and analytical applications. Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.

HY-N0043R

Ginsenoside Rd (Standard) Gypenoside VIII (Standard)	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Reference Standards NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite
Ginsenoside Rd (Standard) is the analytical standard of Ginsenoside Rd. This product is intended for research and analytical applications. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-130550

(±)7(8)-EpDPA	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
(±)7(8)-EpDPA is an epoxide derivative of docosahexaenoic acid (DHA) metabolized by CYP450 .

HY-N0920R

Dihydrokavain (Standard) 7,8-Dihydrokawain (Standard); 7,8-Dihydrokavain (Standard); Marindinin (Standard)	Structural Classification Natural Products other families Source classification Plants	Reference Standards COX Cytochrome P450
Dihydrokavain (Standard) (7,8-Dihydrokawain (Standard)) is the analytical standard of Dihydrokavain (HY-N0920). This product is intended for research and analytical applications. Dihydrokavain is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, *CYP2C9* (IC₅₀ = 130.95 μM), CYP2C19 (IC₅₀ = 10.05 μM) and CYP3A4 (IC₅₀ = 78.59 μM). Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects.

HY-30152R

Xanthotoxol (Standard) 8-Hydroxypsoralen (Standard)	Structural Classification Monophenols other families Source classification Coumarins Phenols Phenylpropanoids Plants Endogenous metabolite	Reference Standards 5-HT Receptor Reactive Oxygen Species (ROS) Endogenous Metabolite
Xanthotoxol (Standard) is the analytical standard of Xanthotoxol. This product is intended for research and analytical applications. Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC₅₀s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation .

HY-N0693

Schisandrin A 5+ Cited Publications Schizandrin-A; Wuweizisu-A; Deoxyschizandrin	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Cytochrome P450 Autophagy Virus Protease
Schisandrin A inhibits *CYP3A* activity with an IC₅₀ of 6.60 μM and K_i of 5.83 μM, respectively.

HY-N3769

Dipterocarpol	Infection Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Inflammation/Immunology Disease Research Fields	Others
Dipterocarpol is a dammarane-type triterpenoid. Dipterocarpol is substrate of the bacterial steroid-hydroxylase CYP106A2 .

HY-N12530

16,17-EDT	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
16,17-EDT is an oxylipin and a metabolite of adrenic acid formed by the cytochrome P450 (CYP) pathway .

HY-W008772

4-Hydroxymephenytoin	Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Drug Metabolite
4-Hydroxymephenytoin is a metabolism of an antiepileptic agent mephenytoin, which is used as a CYP2C19 substrate.

HY-W011956

6-Hydroxymelatonin	Structural Classification Natural Products Monophenols Source classification Phenols Endogenous metabolite	Drug Metabolite Endogenous Metabolite
6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2.

HY-N1201

Apigenin Maximum Cited Publications 28 Publications Verification 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1	Structural Classification Classification of Application Fields Flavones Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Sunscreen Phenols Polyphenols Cosmetic Research Umbelliferae Baccharis sarothroides A.Gray Disease Research Fields Cancer	Autophagy Cytochrome P450 Endogenous Metabolite
Apigenin (4',5,7-Trihydroxyflavone) is a competitive *CYP2C9* inhibitor with a K_i of 2 μM.

HY-N0779

Isosilybin Isosilybinin	Structural Classification Classification of Application Fields Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Flavanonols Flavonoids Glycine soya Phenols Polyphenols Disease Research Fields Cancer	Cytochrome P450
Isosilybin (Isosilybinin) is a flavonoid from Silybum marianum; inhibits *CYP3A4* induction with an IC₅₀ of 74 μM.

HY-N0370

Bergapten 5 Publications Verification 5-Methoxypsoralen	Structural Classification other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Cytochrome P450 Autophagy
Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human *CYP* isoforms.

HY-133091R

7-Ethoxycoumarin (Standard)	Structural Classification Citrus × aurantium Linnaeus Source classification Rutaceae Coumarins Phenylpropanoids Plants	Cytochrome P450
7-Ethoxycoumarin (Standard) is the analytical standard of 7-Ethoxycoumarin. This product is intended for research and analytical applications. 7-Ethoxycoumarin is a substrate of cytochrome P450 (CYP450). 7-Ethoxycoumarin has been used for the functional characterization of various CYPs and for the generation of 7-hydroxycoumarin (HY-N0573) .

HY-N1407R

Polygalaxanthone III (Standard)	Structural Classification Xanthones Source classification Polygalaceae Phenols Polyphenols Plants Polygala tenuifolia Willd.	Reference Standards Cytochrome P450
Polygalaxanthone III (Standard) is the analytical standard of Polygalaxanthone III. This product is intended for research and analytical applications. Polygalaxanthone III is extracted from polygala tenuifolia wild, has inhibitory effect towards CYP450 enzyme. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC₅₀ of 50.56 μM .

Cat. No.	Product Name	Chemical Structure

HY-Y0110S1

2-Naphthol-d7
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol . 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-17356S

Fenofibrate-d6
Fenofibrate-d₆ is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

HY-B1184S1

Mephenytoin-d5
Mephenytoin-d₅ is the deuterium labeled Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate .

HY-13600S1

Clobetasol propionate-d5
Clobetasol propionate-d₅ is a deuterium substitute of Clobetasol propionate. Clobetasol propionate is a potent, selective *CYP3A5* inhibitor with a IC₅₀ of 0.206 μM and has potential for use in the study of psoriasis and other skin diseases .

HY-Y0110S

2-Naphthol-d8
2-Naphthol-d₈ is the deuterium labeled 2-Naphthol . 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2) .

HY-B2015S

Carbosulfan-d18
Carbosulfan-d₁₈ is the deuterium labeled Carbosulfan. Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4.

HY-B0822S1

Fipronil-13C6

Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-17356S2

Fenofibrate-13C6
Fenofibrate-13C6 is a deuterated labeled Fenofibrate . Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for *CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4*, respectively.

HY-17356S1

Fenofibrate-d4
Fenofibrate-d₄ is the deuterium labeled Fenofibrate . Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively .

HY-133091S

7-Ethoxycoumarin-d5
7-Ethoxycoumarin-d₅ is deuterium labeled 7-Ethoxycoumarin. 7-Ethoxycoumarin is a substrate for cytochrome P450(CYP450) and has been used in the functional characterization of various CYPs .

HY-135810S

Cletoquine-d4

Cletoquine-d₄ is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment .

HY-135810S1

Cletoquine-d4-1

Cletoquine-d₄-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment .

HY-B1184S2

Mephenytoin-d8
Mephenytoin-d₈ is the deuterium labeled Mephenytoin . Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate .

HY-N0893S

Tetrahydrocurcumin-d6
Tetrahydrocurcumin-d₆ is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin is a Curcuminoid which displays inhibitory activity for CYP2C9 and CYP3A4 .

HY-B0105S1

Ketoconazole-d4
Ketoconazole-d₄ is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

HY-B0105S

Ketoconazole-d8
Ketoconazole-d₈ is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

HY-W777442

Cletoquine-d4 Oxalate

Cletoquine-d₄ Oxalate is the deuterium labeled Cletoquine (oxalate) (HY-135810A). Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment .

HY-B0852S

Tebuconazole-d9
Tebuconazole-d₉ is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.

HY-B0352AS

(S)-Mirtazapine-d3
(S)-Mirtazapine-d₃ is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].

HY-B1184S3

Mephenytoin-13C,d3
Mephenytoin-13C,d3 is a deuterated labeled Mephenytoin . Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate .

HY-166670S

Ketoconazole carbonyl-13C
Ketoconazole carbonyl- ¹³C (Ketoconazol- ¹³C) is ¹³C labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

HY-W754151

N-Desmethyl apalutamide-d4

N-Desmethyl apalutamide-d₄ is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-W744187

Clobetasol 17-Propionate-d5
Clobetasol 17-Propionate-d₅ is the deuterium labeled Clobetasol propionate (HY-13600). Clobetasol propionate is a potent and selective CYP3A5 inhibitor with an IC₅₀ of 0.206 μM. Clobetasol propionate has no inhibiting on CYP3A4 or other major CYPs. Clobetasol propionate is a corticosteroid and has the potential for psoriasis and other dermatoses research .

HY-135331S

N-Desmethyl-Apalutamide-15N,d4

N-Desmethyl-Apalutamide-15N,d4 is the ¹⁵N and deuterium labeled isotope of N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-Z0056S

Bromobenzene-d5
Bromobenzene-d₅ is the deuterium labeled Bromobenzene. Bromobenzene is a well-known environmental toxin which causes liver and kidney damage through CYP450-mediated bio-activation to generate reactive metabolites and, consequently, oxidative stress .

HY-I0736S

Isonicotinic acid-d4
Isonicotinic acid-d₄ is the deuterium labeled Isonicotinic acid . Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C .

HY-B0973S

Dibenzothiophene-d8

Dibenzothiophene-d₈ is the deuterium labeled Dibenzothiophene (HY-B0973). Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with K_m of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms .

HY-B0507S

Sulfathiazole-d4

Sulfathiazole-d₄ is a deuterium labeled Sulfathiazole. Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish .

HY-B0365AS

Memantine-d6 hydrochloride
Memantine-d₆ (hydrochloride) is the deuterium labeled Memantine hydrochloride. Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate affinity, uncompetitive NMDA receptor antagonist, inhibit CYP2B6 and CYP2D6 with K_is of 0.51 nM and 94.9 μM, respectively .

HY-B0725S

Doxepin-d3 hydrochloride
Doxepin-d₃ (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2 .

HY-100665S

Dehydroaripiprazole-d8
Dehydroaripiprazole-d₈ is deuterium labeled Dehydroaripiprazole. Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole .

HY-100641S

4-Hydroxytolbutamide-d9
4-Hydroxytolbutamide-d₉ is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic .

HY-B0352BS

(R)-Mirtazapine-d3
(R)-Mirtazapine-d₃ is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].

HY-70013S

Abiraterone-d4
Abiraterone-d₄ is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.

HY-100386S

Ticlopidine-d4

Ticlopidine-d₄ is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively .

HY-122410S

Dihydrolanosterol-d7
Dihydrolanosterol-d₇ is deuterium labeled Dihydrolanosterol. Dihydrolanosterol is a subtrate of CYP51 and a cholesterol biosynthesis inhibitor .

HY-14874S

Topiroxostat-d4
Topiroxostat-d₄ is deuterium labeled Topiroxostat. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC₅₀ value of 5.3 nM and a K_i value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment .

HY-103392S

Stiripentol-d9
Stiripentol-d₉ is the deuterium labeled Stiripentol. Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediatated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with K_is of 1.59±0.07 and 0.516±0.065 μM and IC₅₀ of 1.58 and 3.29 μM, respectively .

HY-B0852S2

Tebuconazole-d6

Tebuconazole-d₆ is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC₅₀s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .

HY-144470S

Dehydroindapamide-d3
Dehydroindapamide-d₃ is the deuterium labeled Dehydroindapamide (HY-W420344). Dehydroindapamide is the indole form of Indapamide (HY-B0259). Dehydroindapamide standard can be used to quantitatively measure the Indapamide turnover rate by CYP3A4, which was approximately 10-fold higher than that of Indoline (HY-Y0788), and slightly enhanced affinity for CYP3A4 .

HY-W699866

Gemfibrozil 1-O-β-glucuronide-d6
Gemfibrozil 1-O-β-glucuronide-d₆ is the deuterium labeled Gemfibrozil 1-O-β-glucuronide (HY-129993). Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC₅₀ of 4.07 μM .

HY-119695AS

Simvastatin acid-d6 ammonium

Simvastatin acid-d₆ (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-N0370S

Bergapten-d3
Bergapten-d₃ is deuterium labeled Bergapten. Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.

HY-117580S

16α-Hydroxyprednisolone-d3

16α-Hydroxyprednisolone-d₃ is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily .

HY-17508S1

Clarithromycin-d3

Clarithromycin-d₃ is the deuterium labeled Clarithromycin (HY-17508) . Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC₅₀ (K_i) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .

HY-135334S

ACP-5862-d4

ACP-5862-d₄ is deuterium labeled ACP-5862. ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC₅₀ of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC₅₀ of 3 nM and EC₅₀ of 8 nM .

HY-13463BS

Avatrombopag-d8 hydrochloride

Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-N1201S

Apigenin-d5
Apigenin-d5 is a deuterated labeled Apigenin . Apigenin (4',5,7-Trihydroxyflavone) is a competitive *CYP2C9* inhibitor with a K_i of 2 μM.

HY-N0125S

Diosmetin-d3
Diosmetin-d₃ is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.

HY-10882S

Clotrimazole-d5
Clotrimazole-d₅ is the deuterium labeled Clotrimazole. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity .

Cat. No.	Product Name		Classification

HY-114759

MS-PPOH		Alkynes
MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor . MS-PPOH inhibits *CYP2C8* and *CYP2C9* with IC₅₀s of 15 and 11 μM, respectively . MS-PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-119647

PPOH		Alkynes
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC₅₀ values of 22 μM and 6.5 μM, respectively . PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101016

17-ODYA		Alkynes
17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC₅₀<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes . 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-176497

GW273297X G297X		Alkynes
GW273297X is a *CYP27A1* inhibitor. GW273297X reduces 27HC concentration in E0771 tumors in APOE3 mice. GW273297X can be used in breast cancer research .

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