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Results for "

pulmonary

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (15) Acyltransferase (1) Adenosine Receptor (15) Adrenergic Receptor (51) Akt (4) Aldehyde Dehydrogenase (ALDH) (1) AMPK (1) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (1) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (17) Apelin Receptor (APJ) (2) Apoptosis (36) Aryl Hydrocarbon Receptor (2) Autophagy (11) Bacterial (31) Bcr-Abl (1) Beta-lactamase (1) Biochemical Assay Reagents (6) Bombesin Receptor (1) Btk (1) c-Fms (1) c-Kit (3) Calcium Channel (9) Calmodulin (1) Caspase (2) Cathepsin (2) CCR (2) CDK (1) CFTR (1) Chloride Channel (1) Cholinesterase (ChE) (1) COX (5) CXCR (2) Cyclophilin (1) Cytochrome P450 (3) DAGL (1) Discoidin Domain Receptor (2) DNA/RNA Synthesis (8) Dopamine Receptor (3) Drug Derivative (1) Drug Metabolite (5) E1/E2/E3 Enzyme (2) EGFR (2) Elastase (5) Endogenous Metabolite (22) Endothelin Receptor (11) Enterovirus (1) Epoxide Hydrolase (1) ERK (5) Estrogen Receptor/ERR (3) Factor Xa (2) FGFR (1) FLT3 (1) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) FOXO (1) Fungal (3) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (1) Glucocorticoid Receptor (1) Glutathione Peroxidase (2) Glutathione S-transferase (1) GPR109A (1) GPR84 (1) GSK-3 (1) Guanylate Cyclase (5) HDAC (12) Hexokinase (2) HIF/HIF Prolyl-Hydroxylase (3) Histamine Receptor (1) Histone Methyltransferase (2) HIV (2) HSP (2) iGluR (1) IKK (3) Influenza Virus (6) Integrin (9) Interleukin Related (19) Isotope-Labeled Compounds (11) Itk (1) JAK (2) JNK (5) Keap1-Nrf2 (6) Leukotriene Receptor (6) Lipase (1) Liposome (7) Lipoxygenase (5) LPL Receptor (10) mAChR (34) Macrophage migration inhibitory factor (MIF) (1) MDM-2/p53 (1) Mitochondrial Metabolism (2) Mitophagy (2) MMP (6) Monoamine Oxidase (3) mTOR (3) Mucin (1) nAChR (2) NADPH Oxidase (2) Neprilysin (2) Neurokinin Receptor (2) NF-κB (13) NO Synthase (1) NOD-like Receptor (NLR) (5) Notch (2) Opioid Receptor (4) P-glycoprotein (2) P2Y Receptor (3) p38 MAPK (11) Parasite (10) PARP (1) PDGFR (5) PERK (1) Phosphatase (1) Phosphodiesterase (PDE) (57) Phospholipase (2) PI3K (12) PKG (1) PPAR (3) Prostaglandin Receptor (15) PROTACs (2) Proteasome (1) Reactive Oxygen Species (8) RET (2) ROCK (1) ROS Kinase (1) RSV (2) SARS-CoV (3) Ser/Thr Protease (3) Sigma Receptor (2) Small Interfering RNA (siRNA) (2) SOD (2) Sodium Channel (10) SphK (1) Src (3) STAT (7) TGF-beta/Smad (12) TGF-β Receptor (9) Thrombin (2) Thymidylate Synthase (1) TNF Receptor (11) Toll-like Receptor (TLR) (1) Trk Receptor (1) TRP Channel (3) Tryptophan Hydroxylase (1) VEGFR (2)
By Research Areas:	Cancer (108) Cardiovascular Disease (127) Endocrinology (34) Infection (54) Inflammation/Immunology (256) Metabolic Disease (23) Neurological Disease (60)
Oligonucleotides:	Cationic Lipids (4) Phospholipids (1) siRNA drugs (2) siRNAs (2)

496

Inhibitors & Agonists

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119904

Malaoxon	Cholinesterase (ChE)	Infection
Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity .

HY-14184

Macitentan 10+ Cited Publications ACT-064992	Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

HY-W001953

2-Naphthalenemethanol	Endogenous Metabolite	Others
2-Naphthalenemethanol is the metabolite of environmental pollutant 2-methylnaphthalene. 2-Naphthalenemethanol covalently binds to alveolar protein and induces pulmonary toxicity .

HY-14184S

Macitentan-d4 ACT-064992-d₄	Isotope-Labeled Compounds Endothelin Receptor Apoptosis	Cardiovascular Disease
Macitentan-d₄ is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].

HY-156963

Aderamastat FP-025	MMP	Inflammation/Immunology
Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor. Aderamastat can be used for the research of asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis .

HY-148670

Pulmonary arterial hypertension agent-1	Others	Cardiovascular Disease
Pulmonary arterial hypertension agent-1 (example 15) is a pulmonary arterial hypertension agent . Pulmonary arterial hypertension agent-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-119904R

Malaoxon (Standard)	Drug Metabolite	Infection
Malaoxon (Standard) is the analytical standard of Malaoxon. This product is intended for research and analytical applications. Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity .

HY-162630

HDAC6-IN-44	HDAC	Inflammation/Immunology
HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC₅₀ value of 8.97 nM. HDAC6-IN-44 can inhibit the idiopathic pulmonary fibrosis (IPF) phenotype and exhibits antifibrotic activity. Additionally, HDAC6-IN-44 reduces fibrogenesis in a bleomycin-induced pulmonary fibrosis mouse model and demonstrates good metabolic stability. HDAC6-IN-44 holds promise for research in the field of idiopathic pulmonary fibrosis .

HY-147936

TP0556351	MMP	Inflammation/Immunology
TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC₅₀ value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF) .

HY-14184R

Macitentan (Standard)	Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Macitentan (Standard) is the analytical standard of Macitentan. This product is intended for research and analytical applications. Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

HY-137976

Penehyclidine hydrochloride Penequinine hydrochloride	mAChR NF-κB Apoptosis Autophagy Akt GSK-3 ERK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation .

HY-142119

Penehyclidine	mAChR NF-κB	Inflammation/Immunology
Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation .

HY-170387

MRS8209	5-HT Receptor	Cardiovascular Disease
MRS8209 is the antagonist for serotonin receptor with a K_i of 4.27 nM for 5-HT2BR. MRS8209 exhibits protective effect on pressure at airway opening (PAO), and can be used in research of pulmonary fibrosis .

HY-136449

Bromchlorbuterol hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Bromchlorbuterol hydrochloride is an active β-adrenergic agonist (β-agonist) and can be used for the research of pulmonary disease and asthma .

HY-P3227

Cyclo(Ala-Arg-Gly-Asp-Mamb) XJ735	Integrin	Inflammation/Immunology
Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective RGD peptide antagonist and has the potential for Pulmonary arterial hypertension Research .

HY-P0012A

Aviptadil acetate 1 Publications Verification Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil acetate induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

HY-138570

HLE-IN-1	Elastase	Inflammation/Immunology
HLE-IN-1 (Compound 4) is a human leukocyte elastase HLE inhibitor (K_i=1.8 nM). HLE-IN-1 is used in emphysema and inflammamry pulmonary research .

HY-P0012

Aviptadil 1 Publications Verification Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)	SARS-CoV	Infection Inflammation/Immunology
Aviptadil is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. Aviptadil induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure, et al .

HY-106364

Peplomycin Bleomycin PEP; Pepleomycin	Antibiotic	Cancer
Peplomycin (Bleomycin PEP; Pepleomycin) is an antibiotic analogue of Bleomycin (HY-108345), with high antitumor effect and less pulmonary toxicity. Peplomycin induce apoptosis in oral squamous carcinoma cell line SSCKN cells and pulmonary fibrosis in rats .

HY-167891

GPD-1116	Phosphodiesterase (PDE) Apoptosis	Inflammation/Immunology
GPD-1116 is an orally active Phosphodiesterase (PDE) 4 and PDE1 inhibitor. GPD-1116 can reduce smoke-induced apoptosis of lung cells. GPD-1116 is effective in several disease models in animals, including emphysema, acute lung injury, chronic obstructive pulmonary disease (COPD), asthma and pulmonary hypertension .

HY-139310

GLPG2938	LPL Receptor	Others
GLPG2938 is a potent and selective S1P2 antagonist. GLPG2938 can be used for the research of idiopathic pulmonary fibrosis .

HY-135088

Autotaxin-IN-4	Phosphodiesterase (PDE)	Inflammation/Immunology
Autotaxin-IN-4 (compound 51), extracted from patent WO2018212534A1, is an Autotaxin inhibitor. Autotaxin-IN-4 has the potential to treat idiopathic pulmonary fibrosis .

HY-B2077

Enviomycin Tuberactinomycin N	Bacterial Antibiotic	Infection
Enviomycin (Tuberactinomycin N) is a antibacterial antibiotic. Enviomycin has been used to research chronic cavitary pulmonary tuberculosis .

HY-121491

ONO-6126	Phosphodiesterase (PDE)	Inflammation/Immunology
ONO-6126 is a PDE4 inhibitor that can be used in research for asthma and chronic obstructive pulmonary disease .

HY-133589

Fulvine	Others	Cardiovascular Disease Metabolic Disease
Fulvine is a pyrrolizidine alkaloid isolated from the seeds of Crotalaria fulva. Fulvine is hepatotoxic and can be used to induce hypertensive pulmonary vascular disease in vivo .

HY-137992

Aucuparin	TGF-beta/Smad	Inflammation/Immunology
Aucuparin, a natural product found in Sorbus aucuparia, inhibits pulmonary fibrosis in a bleomycin (HY-108345)-induced lung fibrosis mouse model. Aucuparin has anti-inflammatory activity and can inhibit the activation of inflammatory factors by TGF-β .

HY-162888

WQ-C-401	PDGFR ERK	Cardiovascular Disease
WQ-C-401 is an orally active platelet-derived growth factor receptor (PDGFR) inhibitor. WQ-C-401 inhibits cell proliferation by blocking PDGFR autophosphorylation in a concentration-dependent manner, with EC₅₀ values of 3.5 nM for PDGFRα Y849 and 5.8 nM for PDGFRβ Y1021. Additionally, WQ-C-401 can inhibit PASMCs proliferation and migration by blocking PDGF-BB-induced ERK1/2 phosphorylation, reducing collagen I synthesis, and increasing α-SMA expression, thereby preventing pulmonary vascular remodeling. WQ-C-401 holds promise for research in the field of pulmonary arterial hypertension .

HY-162929

TP-DEA2	TGF-β Receptor	Inflammation/Immunology
TP-DEA2, a predictable-release Triptolide (HY-32735) prodrug, block Bleomycin-induced pulmonary fibrosis and inflammation. TP-DEA2 significantly inhibits α-SMA production .

HY-B2237A

Lysozyme chloride	Bacterial HIV	Infection
Lysozyme chloride is a bactericidal enzyme, and it lyses gram-positive bacteria. Lysozyme chloride can also be used for the research of HIV infection and pulmonary emphysema .

HY-143688

EDMPC	Liposome	Others
EDMPC, a cationic lipid, has an enhanced ability to deliver DNA to pulmonary tissues. EDMPC mediates intralobar DNA delivery to rodents .

HY-114538

Asobamast	TNF Receptor	Cardiovascular Disease Inflammation/Immunology
Asobamast is a potent, orally active antiallergic agent that inhibits ige mediated passive pulmonary allergic responses in rats (ED₅₀=4.7 mg/kg) and inhibits antigen-induced mediator release from sensitized guinea pig lung fragments .

HY-170419

APJ receptor agonist 10	Apelin Receptor (APJ)	Cardiovascular Disease
APJ receptor agonist 10 (Compound I choline salt) modulates the activity of APJ receptor and can be used in research about pulmonary arterial hypertension. APJ receptor agonist 10 exhibits good bioavailability other than its free base form .

HY-109190

Seralutinib 1 Publications Verification GB002; PK10571	PDGFR c-Fms c-Kit	Cardiovascular Disease
Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC₅₀s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .

HY-14786

Darotropium bromide GSK233705	mAChR	Neurological Disease Inflammation/Immunology
Darotropium bromide (GSK233705), a long-acting muscarinic antagonist and an inhaled anticholinergic, can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-15545

AZD-4818	CCR	Neurological Disease Inflammation/Immunology Endocrinology
AZD-4818 is a potent antagonist of chemokine CCR1. AZD-4818 can be used for researching chronic obstructive pulmonary disease (COPD) .

HY-117024

Abediterol napadisylate AZD0548 napadisylate; LAS100977 napadisylate	Adrenergic Receptor	Inflammation/Immunology
Abediterol napadisylate is an inhaled long-acting β2-adrenoceptor agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .

HY-168087

GSK3335103	Integrin	Cardiovascular Disease
GSK3335103 is an orally active, non-peptide α_vβ₆ integrin inhibitor (pIC₅₀=8). GSK3335103 can be used in the study of pulmonary fibrosis .

HY-12514

NK3201	Ser/Thr Protease
NK3201 is an orally active chymase inhibitor (IC₅₀: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein .

HY-120322

MK-0969	mAChR	Others
MK-0969 is a M3 antagonist. MK-0969 can be used for research about chronic obstructive pulmonary disease and urinary incontinence .

HY-111144

Abediterol AZD0548; LAS100977	Adrenergic Receptor	Inflammation/Immunology
Abediterol (LAS100977) is an inhaled long-acting β2-adrenoceptor agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .

HY-121025

BUR1	TGF-β Receptor	Others
BUR1 is a BMP upregulator (EC₅₀: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline (HY-N0750) induced rats .

HY-D0205AR

Carbocisteine (Standard)	Enterovirus	Infection Inflammation/Immunology
Carbocisteine (Standard) is the analytical standard of Carbocisteine. This product is intended for research and analytical applications. Carbocisteine, a mucolytic agent, can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-B0010E

Arformoterol maleate (R,R)-Formoterol maleate	Adrenergic Receptor	Inflammation/Immunology
Arformoterol ((R,R)-Formoterol) maleate, the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a K_d of 2.9 nM. Arformoterol maleate can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-B0010A

Arformoterol 1 Publications Verification (R,R)-Formoterol	Adrenergic Receptor	Inflammation/Immunology
Arformoterol ((R,R)-Formoterol), the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a K_d of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-17417A

Naloxone 2 Publications Verification	Opioid Receptor	Neurological Disease Cancer
Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias .

HY-B2237

Lysozyme from chicken egg white 5+ Cited Publications	Bacterial HIV	Infection
Lysozyme from chicken egg white is a bactericidal enzyme, and it lyses gram-positive bacteria. Lysozyme from chicken egg white can also be used for the research of HIV infection and pulmonary emphysema .

HY-B0010D

Arformoterol tartrate (R,R)-Formoterol tartrate	Adrenergic Receptor	Inflammation/Immunology
Arformoterol ((R,R)-Formoterol) tartrate, the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a K_d of 2.9 nM. Arformoterol tartrate can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-19830

AN3199	Phosphodiesterase (PDE)	Inflammation/Immunology
AN3199 is a PDE4 inhibitor with an IC₅₀ of 94.5 nM. AN3199 can be used for the research of inflammation-associated diseases such as asthma and chronic obstructive pulmonary disease (COPD) .

HY-105686

FR-229934	Phosphodiesterase (PDE)	Cardiovascular Disease
FR-229934 is a PDE V inhibitor extracted from patent WO2019130052A1. FR-229934 can be used for the research of pulmonary arterial hypertension and erectile dysfunction .

HY-W005379

DGM	TGF-beta/Smad	Inflammation/Immunology
DGM is an inhibitor of the TGF-β1/Smad signaling pathway with significant antifibrotic effects. DGM inhibits the epithelial-mesenchymal transition (EMT) process in alveolar epithelial cells and slows the progression of pulmonary fibrosis in vivo by reducing lung inflammation, improving lung function, and decreasing extracellular matrix (ECM) remodeling. DGM can be used in research on idiopathic pulmonary fibrosis (IPF) and EMT-related diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W001953

2-Naphthalenemethanol	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Naphthalenemethanol is the metabolite of environmental pollutant 2-methylnaphthalene. 2-Naphthalenemethanol covalently binds to alveolar protein and induces pulmonary toxicity .

HY-B2237

Lysozyme from chicken egg white 5+ Cited Publications	Infection Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Bacterial HIV
Lysozyme from chicken egg white is a bactericidal enzyme, and it lyses gram-positive bacteria. Lysozyme from chicken egg white can also be used for the research of HIV infection and pulmonary emphysema .

HY-101848

Latrunculin B	Infection Animals Classification of Application Fields Marine natural products Sponge Disease Research Fields	Fungal
Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity .

HY-N7922

Urolithin M5 Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Source classification Phenols Polyphenols Plants Burseraceae	Influenza Virus
Urolithin M5 is a neuraminidase inhibitor that can be isolated from Ganlanye. Urolithin M5 has antiviral activity in vitro and in vivo by inhibiting the activity of viral NA. Urolithin M5 can increase the survival rate and improve pulmonary edema in pr8-infected mouse models. Urolithin M5 can be used in anti-influenza research .

HY-D0205A

Carbocisteine Carbocysteine	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	NF-κB PERK Keap1-Nrf2 Apoptosis
Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research .

HY-N2922

β-Amyrin	Structural Classification Monophenols Celastrus hindsii Benth. Celastraceae Phenols Plants	Amyloid-β NF-κB
β-Amyrin shows effectively counteract amyloid β (Aβ)-induced impairment of long-term potentiation (LTP). β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound .

HY-D0205AR

Carbocisteine (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Enterovirus
Carbocisteine (Standard) is the analytical standard of Carbocisteine. This product is intended for research and analytical applications. Carbocisteine, a mucolytic agent, can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-B0394R

Atropine sulfate monohydrate (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (sulfate monohydrate) (Standard) is the analytical standard of Atropine (sulfate monohydrate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-B1205AR

Atropine sulfate (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-N9508

Perilla ketone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Source classification Plants Erigeron breviscapus (Vant.) Hand.-Mazz. Inflammation/Immunology Disease Research Fields	Cytochrome P450
Perilla ketone is a naturally occurring xenobiotic compound. Perilla ketone is activated by pulmonary P450 cytochrome enzymes in the lung, resulting in severe pulmonary damage and development of diffuse pulmonary edema .

HY-N8278

Dermatan sulphate sodium	Structural Classification Natural Products Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Thrombin
Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation .

HY-N0750

Monocrotaline Maximum Cited Publications 33 Publications Verification Crotaline	Structural Classification Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Crotalaria pallida Ait. Plants Disease Research Fields Cancer	Others
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC₅₀s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. ^[2][6][8].

HY-A0126A

Epoprostenol sodium Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
Epoprostenol sodium (Prostaglandin I2) sodium salt, the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation .

HY-N12777

Coixenolide	Structural Classification Natural Products Gramineae Source classification Coix lacryma-jobi Linn. Plants	Endogenous Metabolite
Coixenolide can be isolated from coix seeds, and exhibits anti-inflammatory, anti-tumor and pain-reducing activities. Coixenolide stimulates the lung, heart, striated and smooth muscles at low doses, while inhibits at high doses. Coixenolide dilates pulmonary veins and improves pulmonary blood circulation .

HY-B0809A

Theophylline monohydrate 1,3-Dimethylxanthine monohydrate; Theo-24 monohydrate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite
Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-B0809

Theophylline 5+ Cited Publications 1,3-Dimethylxanthine; Theo-24	Structural Classification Classification of Application Fields Source classification Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Alkaloids Immune System Disorder Microorganisms Other Alkaloids Disease markers Disease Research Fields Theaceae Cancer	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-B0809B

Theophylline sodium acetate 1,3-Dimethylxanthine sodium acetate; Theo-24 sodium acetate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor
Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-133594

Sandaracopimaric acid	Cardiovascular Disease Structural Classification Cupressaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Callitris quadrivalvis Plants Disease Research Fields	GABA Receptor
Sandaracopimaric acid is a diterpenoid with anti-inflammatory effect. Sandaracopimaric acid reduces the contraction of phenylephrine-induced pulmonary arteries with an EC₅₀ of 43.93 μM .

HY-N3196

Neotuberostemonine	Alkaloids Structural Classification Classification of Application Fields Stemonaceae Source classification Plants Inflammation/Immunology Disease Research Fields Stemona tuberosa Lour. Indole Alkaloids	Bacterial
Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages .

HY-B1864AR

Kasugamycin (hydrochloride) (Standard)	Structural Classification Microorganisms Antibiotics Resistance Selection Source classification Antibacterial Disease Research Other Antibiotics Plant agriculture research	Bacterial Antibiotic
Kasugamycin (hydrochloride) (Standard) is the analytical standard of Kasugamycin (hydrochloride). This product is intended for research and analytical applications. Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-B1864A

Kasugamycin hydrochloride 1 Publications Verification Ksg hydrochloride	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Biological Pesticide Research Plant agriculture research Agricultural Research Infection Microorganisms Antibiotics Resistance Selection Disease Research Fields	Bacterial Antibiotic
Kasugamycin hydrochloride (Ksg hydrochloride) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin hydrochloride (Ksg hydrochloride) mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation .

HY-N1132R

D-(+)-Trehalose (Standard)	Structural Classification Polysaccharides Source classification Endogenous metabolite Saccharides	Endogenous Metabolite
Etamivan (Standard) is the analytical standard of Etamivan. This product is intended for research and analytical applications. Etamivan (Ethamivan), an orally active respiratory stimulant, is mainly used in the research of barbiturate overdose and chronic obstructive pulmonary disease .

HY-W018653R

Cyclohexaneacetic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Naloxone (Standard) is the analytical standard of Naloxone. This product is intended for research and analytical applications. Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias .

HY-N0484

Liensinine 5+ Cited Publications	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Alkaloid Dimers	Autophagy Mitophagy Apoptosis
Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-N12715

Valerena-4,7(11)-diene	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Others
Valerena-4,7(11)-diene is a tranquilizer. Valerena-4,7(11)-diene suppresses stress-induced excitatory behaviors. Valerena-4,7(11)-diene is expressed via olfactory stimulation and pulmonary absorption .

HY-N0368

Linalool 2 Publications Verification	Cardiovascular Disease Structural Classification Other Monoterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Amberboa moschata (L.) DC. Umbelliferae Plants Endogenous metabolite Disease Research Fields	TNF Receptor Apoptosis iGluR Endogenous Metabolite Bacterial
Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-109506

DPPC 5+ Cited Publications 129Y83	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Liposome Endogenous Metabolite
DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-N0232

Psoralidin 4 Publications Verification	Structural Classification Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Cancer	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial
Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation .

HY-N5136

25(R,S)-Ruscogenin	Liliaceae Microorganisms Classification of Application Fields Source classification Liriope platyphylla Wang et Tang Plants Disease Research Fields Steroids Cancer	Apoptosis PI3K Akt mTOR
Ruscogenin suppresses HCC metastasis by reducing the expression of MMP-2, MMP-9, uPA, VEGF and HIF-1α via regulating the PI3K/Akt/mTOR signaling pathway . And Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by su

HY-136409R

N-Decanoyl-L-homoserine lactone (Standard)	Microorganisms Source classification	Bacterial Reactive Oxygen Species
Formoterol (hemifumarate hydrate) (Standard) is the analytical standard of Formoterol (hemifumarate hydrate). This product is intended for research and analytical applications. Formoterol hemifumarate hydrate is a selective, long-acting beta 2-adrenoceptor agonist. Formoterol is a bronchodilator used for the research of the asthma and chronic obstructive pulmonary disease (COPD). Formoterol hemifumarate hydrate induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury .

HY-126232

Verproside	Plantaginaceae Infection Structural Classification Iridoids Veronica officinalis L. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	NF-κB TNF Receptor IKK
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD) .

HY-109506R

DPPC (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Liposome Endogenous Metabolite
DPPC (Standard) is the analytical standard of DPPC. This product is intended for research and analytical applications. DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-N0232R

Psoralidin (Standard)	Structural Classification Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial
Psoralidin (Standard) is the analytical standard of Psoralidin. This product is intended for research and analytical applications. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation .

HY-N0485

Liensinine Diperchlorate 5+ Cited Publications	Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Phenols Polyphenols Nelumbo nucifera Gaertn. Plants Disease Research Fields Nymphaeaceae	Autophagy Mitophagy
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-76200

Voriconazole 5+ Cited Publications UK-109496	Microorganisms Source classification	Fungal Bacterial
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .

HY-129554R

cis-9,10-Epoxystearic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Arformoterol (tartrate) (Standard) is the analytical standard of Arformoterol (tartrate). This product is intended for research and analytical applications. Arformoterol ((R,R)-Formoterol) tartrate, the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol tartrate can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-N11431

ent-Toddalolactone	Toddalia asiatica (L.) Lam. Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants	Others
ent-Toddalolactone is a natural compound with anti-inflammatory and anticancer activities. Ent-Toddalolactone has shown inhibitory effects on phosphodiesterase-4 (PDE4) in vitro and is a potential drug target for inhibiting asthma and chronic obstructive pulmonary disease. The activity of ent-Toddalolactone is related to its unique chemical structure, and some of its derivatives showed IC₅₀ values below 10 μM in inhibition experiments, showing high biological activity .

HY-N2922R

β-Amyrin (Standard)	Structural Classification Monophenols Celastrus hindsii Benth. Celastraceae Phenols Plants	Amyloid-β
β-Amyrin shows effectively counteract amyloid β (Aβ)-induced impairment of long-term potentiation (LTP). β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound .

HY-N0512

Loganin 4 Publications Verification Loganoside	Structural Classification Iridoids Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants Disease Research Fields Cancer	Reactive Oxygen Species TNF Receptor Interleukin Related
Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .

HY-N1584

Halofuginone 10+ Cited Publications RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N0031R

Plantamajoside (Standard)	Plantaginaceae Structural Classification Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plantago asiatica L. Plants	NF-κB PI3K Apoptosis Autophagy p38 MAPK Src
Plantamajoside (Standard) is the analytical standard of Plantamajoside. This product is intended for use in research and analytical applications. Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects .

HY-N0031

Plantamajoside 1 Publications Verification	Plantaginaceae Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plantago asiatica L. Plants Inflammation/Immunology Disease Research Fields	NF-κB PI3K Akt Apoptosis Autophagy p38 MAPK Src
Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects .

HY-N2429

Sphondin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Plants Seriphidium transiliense Inflammation/Immunology Disease Research Fields	COX
Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE₂ release in A549 cells .

HY-N1584A

Halofuginone hydrobromide 10+ Cited Publications RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N0512R

Loganin (Standard)	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Apoptosis Keap1-Nrf2 TNF Receptor Interleukin Related
Loganin (Standard) is the analytical standard of Loganin. This product is intended for research and analytical applications. Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .

HY-N1584R

Halofuginone (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Source classification Saxifragaceae Plants	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-119846

Afromosin	Structural Classification Flavonoids Leguminosae Source classification Plants Callerya dielsiana (Harms) P. K. Loc ex Z. Wei & Pedley Astragalus membranaceus (Fisch.) Bunge Isoflavones Fabaceae	Others
Afromosin is an isoflavone, that can be isolated from Millettia dielsiana Harms. Afromosin exhibits remarkable tumor inhibitory effects .

HY-N2807

Acanthoside B	Monophenols Cistanche salsa (C. A. Mey.) G. Beck Source classification Lignans Phenols Orobanchaceae Phenylpropanoids Plants	Others
Acanthoside B is a potential bioactive lignan with anti-inflammatory and anti-amnesic activities. Acanthoside B can be used for alzheimer's disease and lung inflammation research

HY-N1584AR

Halofuginone (hydrobromide) (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Source classification Saxifragaceae Plants	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N0160R

Kinetin (Standard)	Structural Classification Natural Products other families Source classification Plants	SOD
Kinetin (Standard) is the analytical standard of Kinetin. This product is intended for research and analytical applications. Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects .

Cat. No.	Product Name	Chemical Structure

HY-14184S

Macitentan-d4
Macitentan-d₄ is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].

HY-14779S

Riociguat-13C,d6
Riociguat- ¹³C,d₆ is the ¹³C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

HY-B1037S

Salbutamol-d3
Salbutamol-d₃ is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-B1037S2

Salbutamol-d9
Salbutamol-d₉ is the deuterium labeled Salbutamol. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-90009S

Tadalafil-d3
Tadalafil-d₃ is the deuterium labeled Nortadalafil. Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.

HY-B0241S

Ipratropium-d3 bromide
Ipratropium-d₃ (bromide) is the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].

HY-B1810S

Tulobuterol-D9 hydrochloride
Tulobuterol-d₉ (hydrochloride) is the deuterium labeled Tulobuterol. Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength[1].

HY-B0809S1

Theophylline-d3

Theophylline-d₃ is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-169071S

ATX-1905
ATX-1905 is a positron emission tomography (PET) tracer that demonstrates good autotaxin (ATX) binding specificity and achieves semiquantification of lung ATX expression levels, which are elevated in fibrotic lungs. ATX-1905 exhibits elevated uptake in Bleomycin (HY-108345)-induced pulmonary fibrosis (BPF) lungs. ATX-1905 is promising for research of idiopathic pulmonary fibrosis (IPF) .

HY-B1037S3

Salbutamol-d9 acetate
Salbutamol-d₉ (acetate) is the deuterium labeled Salbutamol[1]. Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease (COPD).

HY-109506S2

(Rac)-DPPC-d6
(Rac)-DPPC-d6 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-B0010AS

Formoterol-d3
Formoterol-d₃ is deuterium labeled Arformoterol. Arformoterol ((R,R)-Formoterol), the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD)[1][2].

HY-109506S9

DPPC-13C2
DPPC-13C2 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-W010201S

Citronellol-d6

Citronellol-d₆ is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-B0241S1

Ipratropium-d7 bromide
Ipratropium-d₇ (bromide)eis the deuterium labeled Ipratropium bromide. Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].

HY-W010410S

Oct-1-en-3-ol-d3

Oct-1-en-3-ol-d₃ is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-12678S1

Entrectinib-d8

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .

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