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Results for "

Arthritis

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (143) Cardiovascular Disease (14) Endocrinology (14) Infection (42) Inflammation/Immunology (486) Metabolic Disease (25) Neurological Disease (25)
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514

Inhibitors & Agonists

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Peptides

Inhibitory Antibodies

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Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99335

Vunakizumab Anti-Human IL17A Recombinant Antibody	Interleukin Related	Inflammation/Immunology
Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant human IgGκ monoclonal antibody that targets IL-17A and inhibits its interaction with the IL-17 receptor. Vunakizumab can be used to study autoimmune diseases such as psoriatic arthritis, ankylosing spondylitis, multiple sclerosis and inflammatory arthritis .

HY-111284

Kebuzone Ketazone; Ketophenylbutazone	Others	Inflammation/Immunology
Kebuzone is a non-steroidal anti-inflammatory substance that may be studied in inflammatory diseases such as thrombophlebitis and rheumatoid arthritis .

HY-114897

L-167307	p38 MAPK	Inflammation/Immunology
L-167307 is an effective pyrrole-based p38 kinase inhibitor that can reduce secondary paw swelling in rat adjuvant-induced arthritis models .

HY-112319

MK-8457	Syk	Inflammation/Immunology
MK-8457 is a dual SYK/ZAP70 inhibitor. MK-8457 can be used for research of rheumatoid arthritis .

HY-107340

Diftalone Aladione; L 5418	Others	Inflammation/Immunology
Diftalone (Aladione) is an anti-inflammatory agent. Diftalone can be used for research of inflammatory disease, such as rheumatoid arthritis .

HY-106027

Romazarit RO 31-3948	Others	Inflammation/Immunology
Romazarit (RO 31-3948) is an anti-inflammatory agent with antirheumatic effect. Romazarit (30 mg/kg) inhibits the development of hindpaw inflammation in an adjuvant arthritis model .

HY-120677

AHR-15010	Carbonic Anhydrase	Inflammation/Immunology
AHR-15010 is an oral active carbonic anhydrase inhibitor with the IC₅₀ of 0.13 μM. AHR-15010 shows anti-arthritic activity and can be used for study of arthritis .

HY-19680

Prinomide tromethamine	Biochemical Assay Reagents	Inflammation/Immunology
Prinomide tromethamine is an orally available nonsteroidal anti-inflammatory agent. Prinomide tromethamine can be used to study inflammation, such as rheumatoid arthritis .

HY-N9346

Phlorigidoside C	Others	Inflammation/Immunology
Phlorigidoside C, a natural iridoid glucoside, possesses anti-rheumatoid arthritis effect .

HY-121927

Mobiletrex CH-1504	Antifolate Dihydrofolate reductase (DHFR)	Inflammation/Immunology
Mobiletrex is an anti folate and dihydrofolate reductase inhibitor that can be used in research on rheumatoid arthritis .

HY-161455

Xanthine oxidase-IN-13	Xanthine Oxidase	Inflammation/Immunology
Xanthine oxidase-IN-13 (Compound 10) is a selective xanthine oxidase inhibitor (IC₅₀: 149.56 μM for bovine xanthine oxidase). Xanthine oxidase-IN-13 can be used for research of inflammatory arthritis .

HY-P99782

Opinercept	TNF Receptor	Inflammation/Immunology
Opinercept is a tumor necrosis factor-alpha (TNF-alpha) inhibitor. Opinercept can be used for the research of rheumatoid arthritis (RA) .

HY-111037

BMS-457	CCR	Inflammation/Immunology
BMS-457 is a potent and selective CCR1 antagonist. BMS-457 can be used in the study of rheumatoid arthritis .

HY-150732

IRAK4-IN-18	IRAK	Inflammation/Immunology
IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease .

HY-150733

IRAK4-IN-19	IRAK	Inflammation/Immunology
IRAK4-IN-19 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 4.3 nM. IRAK4-IN-19 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-19 can be used for researching arthritis disease .

HY-163386

HFTC-HClO 1	Biochemical Assay Reagents	Others
HFTC-HClO 1 is a stable and sensitive ratiometric probe, which images the endogenous HClO. HFTC-HClO 1 exhibits a main emission peak at 579 nm. HFTC-HClO-1 visualizes HClO generated in the rheumatoid arthritis mouse model .

HY-155031

MCI	Reactive Oxygen Species COX	Inflammation/Immunology
MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC₅₀ value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA) .

HY-116230

BI-L-45 XX	Others	Inflammation/Immunology
BI-L-45 XX is an orally active anti-inflammatory agent. BI-L-45 XX can inhibit the release of neutrophil enzymes and chemotaxis, and is used in the study of adjuvant-induced arthritis .

HY-121292

Clidanac	Oxidative Phosphorylation Mitochondrial Metabolism	Infection
Clidanac is a potent anti-inflammatory agent. Clidanac can uncouple the oxidative phosphorylation and can be used for the research of rheumatoid arthritis .

HY-106897

BF389 Biofor 389	COX Lipoxygenase	Inflammation/Immunology
BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC₅₀s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research .

HY-159614

PG-PS	TNF Receptor Interleukin Related	Inflammation/Immunology
PG-PS is a complex composed of streptococcal cell wall peptidoglycans and polysaccharides with pro-inflammatory and arthritis-inducing activity. PG-PS can be used to establish arthritis models. PG-PS can cause inflammation and joint damage, increase the expression of pro-inflammatory cytokines (TNF-α and IL-1β), and disrupt cellular redox balance .

HY-131705

BTK inhibitor 17	Btk	Inflammation/Immunology
BTK inhibitor 17 is a potent and orally active irreversible BTK inhibitor with an IC₅₀ of 2.1 nM. BTK inhibitor 17 can be used for rheumatoid arthritis research .

HY-126560

F-Amidine	Protein Arginine Deiminase	Inflammation/Immunology
F-Amidine is a Protein arginine deiminase 4 (PAD4) inhibitor. F-Amidine can be used in the study of inflammatory and immune system diseases (such as rheumatoid arthritis) .

HY-115351

GW-3333	TNF Receptor MMP	Inflammation/Immunology
GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production. GW-3333 can be used in research of arthritis .

HY-N2843

α-Amyrin palmitate	Others	Inflammation/Immunology
α-Amyrin palmitate is isolated from Santalum album (sandalwood). α-Amyrin palmitate can be used for the study of arthritis in vivo .

HY-126560A

F-Amidine TFA	Protein Arginine Deiminase	Inflammation/Immunology
F-Amidine TFA is a Protein arginine deiminase 4 (PAD4) inhibitor. F-Amidine TFA can be used in the study of inflammatory and immune system diseases (such as rheumatoid arthritis) .

HY-P99779

Plonmarlimab TJ003234; TJM2	c-Fms SARS-CoV	Infection Inflammation/Immunology
Plonmarlimab (TJ003234) is an anti-GM-CSF monoclonal antibody. Plonmarlimab can be used for research of rheumatoid arthritis and COVID-19 .

HY-116442

Azapropazone	Others	Inflammation/Immunology
Azapropazone is a nonsteroidal anti-inflammatory agent (NSAID). Azapropazone can be used for the research of rheumatoid arthritis and other rheumatoid conditions .

HY-P4684

Osteostatin PTHrP (107–111)	PTHR	Inflammation/Immunology
Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research .

HY-P99210

Olokizumab CDP 6038; OKZ	Interleukin Related	Inflammation/Immunology
Olokizumab (CDP 6038) is a humanized monoclonal antibody targeting the interleukin-6 (IL-6). Olokizumab can be used in research of rheumatoid arthritis (RA) .

HY-125997

BTK inhibitor 10	Btk	Inflammation/Immunology
BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment .

HY-NP102

Highly purified Type II collagen, from bovine articular cartilage Bovine Type II collagen, immunization grade	Biochemical Assay Reagents	Inflammation/Immunology
Highly purified Type II collagen, from bovine articular cartilage (Bovine Type II collagen, immunization grade), an immunization grade, is the major matrix protein in cartilage that can be used for the study of arthritis .

HY-17490

Oxaceprol 1 Publications Verification N-Acetyl-L-hydroxyproline	Amino Acid Derivatives	Inflammation/Immunology
Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis .

HY-163750

KMU-11342	Others	Inflammation/Immunology
KMU-11342 is a potent inhibitor of multi-protein kinase. KMU-11342 plays an important inhibitor of rheumatoid arthritis (RA) research .

HY-108847

Etanercept 5+ Cited Publications	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .

HY-B1456A

Fenoprofen 1 Publications Verification LILLY-53858	Melanocortin Receptor	Inflammation/Immunology
Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation .

HY-111304

MF266-1	Prostaglandin Receptor Thrombopoietin Receptor	Inflammation/Immunology
MF266-1 is a selective E prostanoid receptor 1 (EP1) antagonist with an K_i value of 3.8 nM. MF266-1 also has moderate selectivity for thromboxane A2 receptor (TP). MF266-1 is promising for research of arthritis .

HY-127150

Clofezone Perclusone	Others	Inflammation/Immunology
Clofezone (Perclusone) is a antirheumatic agent. Clofezone can be used in the study of various rheumatic diseases, especially arthritis (RA) and ankylosing spondylitis (AS) .

HY-N12243

Kopsininic acid	Others	Others
Kopsininic acid is a natural product derived from Kopsia hainanensis. Kopsininic acid can be used in the research of rheumatoid arthritis, pharyngitis, tonsillitis and edema .

HY-P9925

Brodalumab 2 Publications Verification AMG 827; KHK4827	Interleukin Related	Inflammation/Immunology
Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis .

HY-164416

DBCO-Dextran sulfate (MW 40000)	Others	Inflammation/Immunology
DBCO-Dextran sulfate (MW 40000) can be used to construct DS-EXOs in cells via click chemistry, that can be used for the research of rheumatoid arthritis (RA) .

HY-P99940

Remtolumab ABT-122	TNF Receptor Interleukin Related	Inflammation/Immunology
Remtolumab (ABT-122) is a dual-variable domain immunoglobulin that neutralises both tumor necrosis factor α (TNFα) and IL-17A. Remtolumab shows dual inhibition of TNFα and IL-17A. Remtolumab can be used for rheumatoid arthritis (RA) research .

HY-148657

Aminopterin N-hydroxysuccinimide ester NHS-Methotrexate	Others	Inflammation/Immunology Cancer
Aminopterin N-hydroxysuccinimide ester(NHS-methotrexate) is an irreversible Methotrexate (HY-14519) influx carrier inhibitor. Aminopterin N-hydroxysuccinimide ester can be used for the research of rheumatoid arthritis and a number of cancers (such as acute lymphoblastic leukemia) .

HY-14750

Rabeximod ROB-803	Toll-like Receptor (TLR)	Neurological Disease Inflammation/Immunology
Rabeximod (ROB-803), an anti-rheumatic compound, impairs the differentiation and function of human pro-inflammatory dendritic cells and macrophages via downregulating TLR2 and TLR4 stimulation. Rabeximod (ROB-803) is used for rheumatoid arthritis (RA) research .

HY-117668

MDL 101146	Elastase	Infection Inflammation/Immunology
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a K_i value of 25 nM. MDL 101146 can be used for the research of arthritis .

HY-12517

GNE-293	PI3K	Inflammation/Immunology
GNE-293 is a potent and selective PI3Kδ inhibitor (IC₅₀ = 4.38 nM). GNE-293 has favorable pharmacokinetic properties. GNE-293 can be used for research of asthma, rheumatoid arthritis, and other inflammatory disorders .

HY-18694

CGS 27023A	MMP	Inflammation/Immunology
CGS 27023A is a non-peptidic and orally active MMP inhibitor with the K_i values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis .

HY-105934A

Ketotrexate sodium Emofolin sodium; 5-methyltetrahydrohomofolate sodium; NSC 139490 sodium	Antifolate	Inflammation/Immunology Cancer
Ketotrexate sodium is an orally active antifolate and immunosuppressant. Ketotrexate sodium has good anti-inflammatory activity and is widely used in rheumatoid arthritis (RA). Ketotrexate sodium is used in research into cancer and autoimmune diseases .

HY-14305

BMS-582949	p38 MAPK	Inflammation/Immunology
BMS-582949 (compound 7k) is an orally active and highly selective p38α MAP kinase inhibitor, with IC₅₀ values of 13 nM for p38α, and 50 nM for cellular TNFα. BMS-582949 can be used for research on rheumatoid arthritis .

HY-P99012

Clazakizumab	Interleukin Related SARS-CoV	Infection Inflammation/Immunology
Clazakizumab is a monoclonal antibody with high affinity and specificity for the IL-6 (interleukin-6) cytokine. Clazakizumab may be helpful in inhibiting the cytokine response to SARS-CoV-2 in COVID-19. Clazakizumab can be used for the research of psoriatic arthritis (PsA) and renal antibody-mediated rejection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17490

Oxaceprol 1 Publications Verification N-Acetyl-L-hydroxyproline	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Amino Acid Derivatives
Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis .

HY-B1271

Sulfinpyrazone G-28315	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Sulfinpyrazone (G-28315) is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects .

HY-P9927

Secukinumab 1 Publications Verification AIN457	Classification of Application Fields Disease Research Fields Cancer	Interleukin Related
Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis .

HY-126114

Lupeol acetate 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Umbelliferae Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	COX Interleukin Related
Lupeol acetate, a derivative of Lupeol, suppresses the progression of rheumatoid arthritis (RA) by inhibiting the activation of macrophages and osteoclastogenesis through downregulations of TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B .

HY-N9346

Phlorigidoside C	Structural Classification Iridoids Classification of Application Fields Terpenoids Labiatae Source classification Phaseolus lunatus L. Plants Inflammation/Immunology Disease Research Fields Saccharides Monosaccharides	Others
Phlorigidoside C, a natural iridoid glucoside, possesses anti-rheumatoid arthritis effect .

HY-N2843

α-Amyrin palmitate	Triterpenes Classification of Application Fields Terpenoids Source classification Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.	Others
α-Amyrin palmitate is isolated from Santalum album (sandalwood). α-Amyrin palmitate can be used for the study of arthritis in vivo .

HY-N12243

Kopsininic acid	Apocynaceae Kopsia hainanensis Tsiang Structural Classification Alkaloids Source classification Plants Indole Alkaloids	Others
Kopsininic acid is a natural product derived from Kopsia hainanensis. Kopsininic acid can be used in the research of rheumatoid arthritis, pharyngitis, tonsillitis and edema .

HY-17490R

Oxaceprol (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Amino Acid Derivatives
Oxaceprol (Standard) is the analytical standard of Oxaceprol. This product is intended for research and analytical applications. Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis .

HY-N1219

Stephanine (-)-Stephanine; l-Stephanine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Menispermaceae Stephania japonica (Thunb.) Miers	Apoptosis Parasite
Stephanine ((-)-Stephanine) is an isoquinoline aporphine-type alkaloid. Stephanine induce apoptosis through the reverse of mitotic exit. Stephanine exhibits Antiplasmodial activity. Stephanine can be used for the research of stomach pain, abdominal pain, arthritis and cancer .

HY-B1271R

Sulfinpyrazone (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Sulfinpyrazone (Standard) is the analytical standard of Sulfinpyrazone. This product is intended for research and analytical applications. Sulfinpyrazone (G-28315) is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects .

HY-P9953

Certolizumab pegol Certolizumab; CDP870	Classification of Application Fields Disease Research Fields Cancer	TNF Receptor
Certolizumab pegol (Certolizumab) is a recombinant, polyethylene glycolylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor-α (TNF-α). Certolizumab pegol can be used for rheumatoid arthritis and Crohn disease research .

HY-N0586A

Norisoboldine hydrochloride (+)-Laurelliptine hydrochloride	Alkaloids Classification of Application Fields Source classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Disease Research Fields Inflammation/Immunology Lindera aggregata (Sims) Kosterm.	Adenosine Receptor
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-N0586

Norisoboldine (+)-Laurelliptine	Alkaloids Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Inflammation/Immunology Disease Research Fields	Adenosine Receptor
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-N12141

Flaccidoside II	Structural Classification Polysaccharides Anemone flaccida Fr. Schmidt Source classification Ranunculaceae Plants Saccharides	Apoptosis
Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome .

HY-N12081

Oxyresveratrol 4-O-β-D-glucopyranoside	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	Biochemical Assay Reagents
Oxyresveratrol 4-O-β-D-glucopyranoside (compound 3) is a natural product that can be obtained from the root bark of Morus atropurpurea. Oxyresveratrol 4-O-β-D-glucopyranoside has potential in studies of diabetes, arthritis, rheumatism, cough and headache .

HY-N0807R

Swertiamarin (Standard)	Structural Classification Monophenols other families Phenols Zanthoxylum chiloperone var. angustifolium Plants	MMP NF-κB JAK Keap1-Nrf2
Swertiamarin (Standard) is the analytical standard of Swertiamarin. This product is intended for research and analytical applications. Swertiamarin is an orally active iridoid compound with hypoglycemic, hypolipidemic, anti rheumatic and antioxidant activities, which can be used in the research of diabetes and arthritis .

HY-N0807

Swertiamarin	Structural Classification Monophenols other families Classification of Application Fields Phenols Zanthoxylum chiloperone var. angustifolium Metabolic Disease Plants Disease Research Fields Cancer	MMP NF-κB JAK Keap1-Nrf2
Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .

HY-N8309

Luteolin-4'-O-glucoside	Punica granatum L. Classification of Application Fields Flavones Source classification Plants Biological Pesticide Research Agricultural Research Flavonoids Phenols Polyphenols Punicaceae Inflammation/Immunology Disease Research Fields Cancer	Interleukin Related
Luteolin-4'-O-glucoside is an IL-5 inhibitor with an IC₅₀ of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity .

HY-13731

PPI-2458	Classification of Application Fields Disease Research Fields Cancer	MetAP
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research .

HY-N6927

Isoforskolin Coleonol B	Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields Pueraria montana (Lour.) Merr.	TNF Receptor Interleukin Related
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis .

HY-N2381

Menthone	Infection Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Labiatae Source classification Erythrina poeppigiana Plants Inflammation/Immunology Disease Research Fields	NF-κB Parasite
Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis .

HY-N0586R

Norisoboldine (Standard)	Alkaloids Structural Classification Source classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.	Adenosine Receptor
Norisoboldine (Standard) is the analytical standard of Norisoboldine. This product is intended for research and analytical applications. Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-P9916

Sarilumab Anti-Human IL6Rα, Human Antibody	Classification of Application Fields Disease Research Fields Cancer	Interleukin Related
Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody. Sarilumab, a interleukin-6 (IL-6) receptor antagonist, binds to the IL-6 receptor with high affinity and inhibits cis and trans signaling by IL-6, resulting in reduced inflammation. Sarilumab can be used for the research of Rheumatoid arthritis .

HY-N6927R

Isoforskolin (Standard)	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Pueraria montana (Lour.) Merr.	TNF Receptor Interleukin Related
Isoforskolin (Standard) is the analytical standard of Isoforskolin. This product is intended for research and analytical applications. Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis .

HY-P99266

Zanolimumab Anti-Human CD4 Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	Others
Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody targets CD4. Zanolimumab effectively inhibits T-cell receptor (TCR) signal transduction. Zanolimumab can be used for the research of heumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma .

HY-N2381R

Menthone (Standard)	Structural Classification Other Monoterpenes Terpenoids Labiatae Source classification Erythrina poeppigiana Plants	NF-κB Parasite
Menthone (Standard) is the analytical standard of Menthone. This product is intended for research and analytical applications. Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis .

HY-N8309R

Luteolin-4'-O-glucoside (Standard)	Flavonoids Punica granatum L. Flavones Source classification Phenols Polyphenols Punicaceae Plants	Interleukin Related
Luteolin-4'-O-glucoside (Standard) is the analytical standard of Luteolin-4'-O-glucoside. This product is intended for research and analytical applications. Luteolin-4'-O-glucoside is an IL-5 inhibitor with an IC₅₀ of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity .

HY-P99220

Tabalumab LY2127399	Classification of Application Fields Disease Research Fields Cancer	TNF Receptor
Tabalumab (LY2127399) is a human anti-BAFF (B-cell activating factor) monoclonal antibody (IgG4 type) with neutralising activity against membrane bound and soluble BAFF. Tabalumab can be used in studies of autoimmune diseases such as rheumatoid arthritis, renal failure and systemic lupus erythematosus .

HY-P99259

Cabiralizumab FPA 008; Anti-Human CSF1R Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	c-Fms
Cabiralizumab (FPA 008) is an anti-CSF1R monoclonal antibody (MAb). Cabiralizumab enhances T cell infiltration and antitumor T cell immune responses. Cabiralizumab inhibits the activation of osteoclasts and blocks bone destruction, and can be used in the research of rheumatoid arthritis (RA). Cabiralizumab can combine with Nivolumab (HY-P9903) for lung cancer research .

HY-N11957

Angeloylbinankadsurin A	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	Others
Angeloylbinankadsurin A (compound 7) is an anti-rheumatoid arthritis (RA) agent that can be isolated from EtOAc and CH2Cl2 extracts of Black Tiger Beard. Angeloylbinankadsurin A exhibits inhibitory activity on RA-FLS cells (IC₅₀=11.70 μM). Angeloylbinankadsurin A is slightly toxic to human cancer cell lines (Hela and BGC-823) (IC₅₀=19.9 μM, 21.93 μM) .

HY-B0300

Penicillamine 2 Publications Verification D-(-)-Penicillamine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Inflammation/Immunology Disease Research Fields	Cuproptosis Drug Metabolite
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .

HY-B0300R

Penicillamine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Cuproptosis Drug Metabolite
Penicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .

HY-P9917

Tocilizumab 20+ Cited Publications Anti-Human IL6R, Humanized Antibody	Classification of Application Fields Disease Research Fields Cancer	Interleukin Related
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .

HY-121351

Inokosterone	Structural Classification other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	Estrogen Receptor/ERR
Inokosterone is a potential agent target of estrogen receptor 1 in rheumatoid arthritis patients .

HY-N9794

Isoboldine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Phenols Polyphenols Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .

HY-N0218

Benzoylmesaconine 1 Publications Verification Mesaconine 14-benzoate	Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields Inflammation/Immunology	Others
Benzoylmesaconine is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis.

HY-N4030

Humantenmine Gelsenicine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids	Others
Humantenmine, a newalkaloid isolated from Gelsemium elegan Banth in China, has the potential for pain and rheumatic arthritis treatment .

HY-N1440

Koumine	Alkaloids Structural Classification Classification of Application Fields Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Inflammation/Immunology Disease Research Fields Indole Alkaloids	Bcl-2 Family
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-113434

5(S)-HETE	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
5(S)-HETE is an endogenous metabolite present in Blood that can be used for the research of Rheumatoid Arthritis, Rhinitis and Asthma .

HY-16569

Colchicine Maximum Cited Publications 32 Publications Verification	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-N3103

p-Coumaric Acid Ethyl Ester Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate	Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology	Drug Metabolite
p-Coumaric Acid Ethyl Ester is the ethyl ester of p-Coumaric acid . p-Coumaric Acid is a potential immunosuppressive agent in treating autoimmune inflammatory diseases like rheumatoid arthritis .

HY-N7703

D-Mannuronic acid sodium	other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Saccharides Monosaccharides	Others
D-Mannuronic acid sodium, isolated from Macrocystis pyrifera, has the potential in autoimmune encephalomyelitis (EAE), adjuvant induced arthritis (AIA), nephrotic syndrome, and acute glomerulonephritis studies .

HY-N12648

Anemarsaponin E1	Structural Classification Polysaccharides Liliaceae Source classification Anemarrhena asphodeloides Bunge Plants Saccharides	Others
Anemarsaponin E1 can be isolated from Guizhi-Shaoyao-Zhimu decoction (GSZD), and can be used for research of rheumatoid arthritis (RA), gout, osteoarthritis, etc .

HY-N1440R

Koumine (Standard)	Alkaloids Structural Classification Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids	Bcl-2 Family
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N6647

Luteolin-7-rutinoside	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Fungal
Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.

HY-N4232

Clematichinenoside AR	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Source classification Clematis chinensis Osbeck Plants Inflammation/Immunology Disease Research Fields	Autophagy
Clematichinenoside AR is a major active ingredient that could be extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects on various diseases, including atherosclerosis (AS) .

HY-16569R

Colchicine (Standard)	Structural Classification Natural Products other families Source classification Plants	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-B0373

Tiopronin	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Others
Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders .

HY-N7601

Benzoylalbiflorin Paeonivayin	Other Monoterpenes other families Classification of Application Fields Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae Inflammation/Immunology Disease Research Fields	Others
Benzoylalbiflorin, a monoterpenoid, is isolated from paeonia lactiflora. paeonia lactiflora is a traditional Chinese medicine that has been used for the research of rheumatoid arthritis, to alleviate inflammation, amenorrhea, epistaxis, abdominal pain, and other symptoms .

HY-113358

6-keto Prostaglandin F1α	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
6-keto Prostaglandin F1α is an endogenous metabolite present in Cerebrospinal_Fluid, Urine and Blood that can be used for the research of Meningitis, Rheumatoid Arthritis and Cardiopulmonary Resuscitation .

Cat. No.	Product Name	Chemical Structure

HY-14519S1

Methotrexate-d3 diammonium

Methotrexate-d₃ diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-B0493S1

Niflumic acid-13C6
Niflumic acid- ¹³C₆ is the ¹³C₆ labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

HY-B0524AS

Betahistine-d3 dihydrochloride
Betahistine-d₃ (dihydrochloride) is the deuterium labeled Betahistine dihydrochloride. Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist[1]. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA)[3].

HY-10582S3

Flurbiprofen-d4

Flurbiprofen-d₄ is deuterated labeled Flurbiprofen (HY-10582). Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-B0493S

Niflumic Acid-d5
Niflumic Acid-d₅ is the deuterium labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis[1][2].

HY-B0634S

Aceclofenac-d4
Aceclofenac-d₄ is the deuterium labeled Aceclofenac. Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis[1][2].

HY-B1456AS

Fenoprofen-13C6(sodium salt hydrate)

Fenoprofen- ¹³C₆ (sodium hydrate) is the ¹³C labeled Fenoprofen (HY-B1456A). Fenoprofen is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation[1][2][3].

HY-13681S

Methylprednisolone acetate-d6
Methylprednisolone acetate-d6 is the deuterium labeled Methylprednisolone acetate (HY-13681). Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo .

HY-18342S

Diflunisal-d3
Diflunisal-d₃ is the deuterium labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.

HY-136540S

Resolvin D3-d5
Resolvin D3-d₅ is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation[1][2].

HY-B0373S1

Tiopronin-d3
Tiopronin-d₃ is the deuterium labeled Tiopronin. Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders[1][2].

HY-14655S

Sulfasalazine-d4
Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4].

HY-B0524AS1

Betahistine-13C,d3 dihydrochloride
Betahistine- ¹³C,d₃ (dihydrochloride) is the ¹³C- and deuterium labeled Betahistine (dihydrochloride). Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist[1]. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA)[3].

HY-15762S

Valdecoxib-d3
Valdecoxib-d₃ is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain[1][2].

HY-17361S

Etofenamate-d4
Etofenamate-d₄ is the deuterium labeled Etofenamate. Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases[1][2][3].

HY-14655S1

Sulfasalazine-d3,15N
Sulfasalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-10582S

Flurbiprofen-d3

Flurbiprofen-d₃ is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

HY-10582S1

Flurbiprofen-d5

Flurbiprofen-d₅ is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

HY-14519S

Methotrexate-d3

Methotrexate-d₃ (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

HY-17589AS

Chloroquine-d5 1 Publications Verification
Chloroquine-d₅ is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589S1

Chloroquine-d4 phosphate

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17474S

Parecoxib-d3

Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

HY-17589S

Chloroquine-d5 diphosphate

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17474AS

Parecoxib-d5 sodium

Parecoxib-d5 (sodium) is the deuterium labeled Parecoxib sodium. Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo[1][2].

HY-10582S2

Flurbiprofen-13C,d3

Flurbiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

HY-10405S

Pamapimod-d4

Pamapimod-d₄ (Ro4402257-d4) is the deuterium labeled Pamapimod. Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment[1][2].

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-114169S

WRG-28-d5
WRG-28-d5 is the deuterium labeled WRG-28(HY-114169).WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC₅₀ of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic

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