1. Gene
  2. Mical1 - microtubule associated monooxygenase, calponin and LIM domain containing 1 Gene

Mical1 - microtubule associated monooxygenase, calponin and LIM domain containing 1 Gene

Mus musculus

Also known as MICAL; Nical; MICAL-1

Gene ID: 171580 | Gene type: protein coding

About Mical1

Summary

Enables several functions, including FAD binding activity; actin binding activity; and Enzyme binding activity. Involved in several processes, including actin filament depolymerization; negative regulation of cellular protein metabolic process; and sulfur oxidation. Located in hippocampal mossy fiber expansion. Orthologous to human MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Mical1 Products(4)

mRNA Protein Name
NM_001164433.1 NP_001157905.1 [F-actin]-monooxygenase MICAL1 isoform 2
NM_001358838.1 NP_001345767.1 [F-actin]-monooxygenase MICAL1 isoform 3
NM_001358839.1 NP_001345768.1 [F-actin]-monooxygenase MICAL1 isoform 4
NM_138315.2 NP_612188.1 [F-actin]-monooxygenase MICAL1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables FAD binding IDA
IDA: Inferred from direct assay
26935886 MGI
enables actin binding IDA
IDA: Inferred from direct assay
23911929 MGI
enables monooxygenase activity IMP
IMP: Inferred from mutant phenotype
16275926 MGI
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
IDA: Inferred from direct assay
23911929 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21730291 MGI
enables protein kinase binding IDA
IDA: Inferred from direct assay
25007825 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
18094055 MGI
Biological Process GO Annotation Evidence Reference Source
involved in actin filament depolymerization IDA
IDA: Inferred from direct assay
23911929 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21730291 MGI
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
21730291 MGI
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21730291 MGI
involved in regulation of regulated secretory pathway IMP
IMP: Inferred from mutant phenotype
25007825 MGI
involved in sulfur oxidation IDA
IDA: Inferred from direct assay
23911929 MGI
Cellular Component GO Annotation Evidence Reference Source
located in hippocampal mossy fiber expansion IMP
IMP: Inferred from mutant phenotype
25007825 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

[F-actin]-monooxygenase MICAL1

F-actin-monooxygenase MICAL1

CasL interacting molecule MICAL

NEDD9-interacting protein with calponin homology and LIM domains

[F-actin]-methionine sulfoxide oxidase MICAL1

microtubule associated monoxygenase, calponin and LIM domain containing 1

molecule interacting with CasL pro

Mical1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Mical1 Q8VDP3 Stk38 Mus musculus Q91VJ4 21730291
Cross
Mical1 Q8VDP3 Stk38l Rattus norvegicus A4GW50 21730291
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Mical1 NCBI NCBI:64780