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Isoforms Recommended:	IL-6

Results for "

IL-6

" in MedChemExpress (MCE) Product Catalog:

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Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990212

*Anti-Mouse IL-6* Antibody (MP5-20F3)**	Interleukin Related	Others
Anti-Mouse IL-6 Antibody (MP5-20F3) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-6.

HY-P0317

*Interleukin (IL)-6* Receptor**	Interleukin Related	Others
Interleukin (IL)-6 Receptor is a peptide, derived from interleukin-6 receptor.

HY-160052

IL-6 aptamer sodium	Interleukin Related	Cancer
IL-6 aptamer sodium is a nucleic acid aptamer that specifically targets *IL-6* and can be used for the specific detection of IL-6 .

HY-RS06776

Il6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il6 Rat Pre-designed siRNA Set A Il6 Rat Pre-designed siRNA Set A

HY-RS06775

Il6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il6 Mouse Pre-designed siRNA Set A Il6 Mouse Pre-designed siRNA Set A

HY-RS06774

IL6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
IL6 Human Pre-designed siRNA Set A contains three designed siRNAs for IL6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL6 Human Pre-designed siRNA Set A IL6 Human Pre-designed siRNA Set A

HY-169420

IL-6-IN-1	Interleukin Related	Inflammation/Immunology
IL-6-IN-1 (Compound 22) inhibits the release of *IL-6* with an IC₅₀ of 1.065 μM. IL-6-IN-1 exhibits anti-inflammatory efficacy in LPS (HY-D1056)-induced acute lung injury in mouse model .

HY-RS17230

Il6st Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Il6st Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il6st gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il6st Mouse Pre-designed siRNA Set A Il6st Mouse Pre-designed siRNA Set A

HY-RS06778

IL6ST Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL6ST Human Pre-designed siRNA Set A contains three designed siRNAs for IL6ST gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL6ST Human Pre-designed siRNA Set A IL6ST Human Pre-designed siRNA Set A

HY-RS06777

IL6R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL6R Human Pre-designed siRNA Set A contains three designed siRNAs for IL6R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL6R Human Pre-designed siRNA Set A IL6R Human Pre-designed siRNA Set A

HY-P9916

Sarilumab Anti-Human IL6Rα, Human Antibody	Interleukin Related	Inflammation/Immunology Cancer
Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody. Sarilumab, a interleukin-6 (IL-6) receptor antagonist, binds to the IL-6 receptor with high affinity and inhibits cis and trans signaling by IL-6, resulting in reduced inflammation. Sarilumab can be used for the research of Rheumatoid arthritis .

HY-P9917

Tocilizumab 25+ Cited Publications Anti-Human IL6R, Humanized Antibody	Interleukin Related	Inflammation/Immunology Cancer
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .

HY-N9315

Episappanol	TNF Receptor Interleukin Related	Inflammation/Immunology
Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the *IL-6* and TNF-α secretion .

HY-N7275

Di-O-methyldemethoxycurcumin	Interleukin Related	Inflammation/Immunology
Di-O-methyldemethoxycurcumin, a curcuminoid analog, inhibits *IL-6* production with an EC₅₀ of 16.20 μg/mL. Anti-inflammatory and antioxidant properties .

HY-161396

Anti-inflammatory agent 76	NO Synthase Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 76 (Compd 8b), an anti-inflammatory agent, exhibits good NO, IL-1β and *IL-6* inhibitory activities .

HY-115910

Y13g	Cholinesterase (ChE) Interleukin Related	Neurological Disease
Y13g is the potent inhibitor of both AChE and *IL-6. Interleukin-6 (IL-6*) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g reverses the STZ (HY-13753)-induced memory deficit, and shows histopathology similarly as in normal animals .

HY-115910A

Y13g dihydrochloride	Interleukin Related Cholinesterase (ChE)	Neurological Disease
Y13g dihydrochloride is the potent inhibitor of both AChE and *IL-6. Interleukin-6 (IL-6*) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g dihydrochloride reverses the STZ (HY-13753)-induced memory deficit, and shows histopathology similarly as in normal animals .

HY-P99287

Elsilimomab B-E8; Anti-IL-6 MAB B-E8	Interleukin Related	Inflammation/Immunology Cancer
Elsilimomab (B-E8) is a IgG1 monoclonal antibody against **interleukin-6 (IL-6), with a K_D of 22 pM and an IC₅₀** of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA) .

HY-146564A

HP210	Glucocorticoid Receptor	Inflammation/Immunology
HP210 is a selective glucocorticoid receptor modulator (SGRM). HP210 can inhibit the mRNA expression of IL-1β and IL-6. HP210 has the potential to study inflammation-related diseases .

HY-163458

Anti-inflammatory agent 77	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 77 (C12) is a β-cycloacinamide derived mono-carbonyl curcumin analog and an inhibitor of interleukin-6 (IL-6). Anti-inflammatory agent 77 can be used in the study of wound healing .

HY-N3380

Linderaspirone A	PGE synthase Interleukin Related	Inflammation/Immunology
Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 .

HY-148238

GNE-2256	IRAK	Inflammation/Immunology
GNE-2256 (molecule 19) is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 K_i=1.4 nM; IL-6 IC₅₀=190 nM) .

HY-N7674A

Angoline hydrochloride	STAT	Cancer
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

HY-N7674

Angoline 2 Publications Verification	Interleukin Related STAT	Cancer
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

HY-150738C

ODN 2088 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 2088 sodium is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 sodium shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 .

HY-150738

ODN 2088	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 .

HY-162681

eeAChE-IN-3	Cholinesterase (ChE) Interleukin Related	Neurological Disease
eeAChE-IN-3 (compound YS3g) is an orally active, potent EeAChE and *IL-6* inhibitor with IC₅₀s of 0.54 μM, 0.49 μM, 8.54 μM and 0.57 μM for EeAChE, RatAChE, RatBuChE and IL-6, respectively. eeAChE-IN-3 improves STZ (HY-13753) (Streptozotocin; HY-13753)-induced learning and memory impairment in mice. eeAChE-IN-3 has the potential for Alzheimer's disease (AD) research .

HY-114592

M199	Toll-like Receptor (TLR) Interleukin Related TNF Receptor	Inflammation/Immunology
M199 is a potent TLR3/TLR9 signaling inhibitor. M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs. M199 is used as a selective inducer of the immune response .

HY-122767

Romurtide Muroctasin	Interleukin Related	Inflammation/Immunology
Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), IL-1 and *IL-6* in vitro .

HY-N2086

Ethyl palmitate 2 Publications Verification Ethyl hexadecanoate	TNF Receptor Interleukin Related NF-κB	Infection Inflammation/Immunology
Ethyl palmitate (Ethyl hexadecanoate) is a CHIKV virus inhibitor with an EC₅₀ value of 0.0068 μM. Ethyl palmitate can reduce levels of TNF-α, *IL-6, and NF-κB* in endotoxemic rats, showing anti-inflammatory activity .

HY-149816

Anti-inflammatory agent 41	Interleukin Related TNF Receptor NF-κB	Inflammation/Immunology
Anti-inflammatory agent 41 (13a) significantly inhibit lipopolysaccharide (LPS)-induced expression of the proinflammatory cytokines *IL-6* and TNF-α on J774A.1, THP-1 and LX-2 cells, and inhibits the activation of the NF-κB pathway .

HY-P99505

Ziltivekimab COR-001; MEDI-5117	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Ziltivekimab (COR-001) is a humanized monoclonal antibody against *IL-6* that effectively reduces serum CRP levels. Ziltivekimab possesses anti-inflammatory activity and can be used in research related to chronic systemic inflammation associated with chronic kidney disease (CKD) and cardiovascular diseases such as atherosclerosis .

HY-P10284

S7	Interleukin Related	Cancer
S7 is an IL-6 receptor antagonist and inhibits the binding between IL-6 and IL-6R. S7 can inhibit angiogenesis and tumor growth .

HY-160026

IL-17 modulator 8	Interleukin Related	Inflammation/Immunology
IL-17 modulator 8 (compound 286) is an orally active modulator of IL-17. IL-17 modulator 8 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 8 can used in study arthritis .

HY-160028

IL-17 modulator 9	Interleukin Related	Inflammation/Immunology
IL-17 modulator 9 (compound 453) is an orally active modulator of IL-17. IL-17 modulator 9 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 9 can used in study inflammation .

HY-134371

IL-17 modulator 2	Interleukin Related	Inflammation/Immunology
IL-17 modulator 2 (compound 159) is an orally active modulator of IL-17. IL-17 modulator 2 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 2 can used in study arthritis .

HY-114360A

Taurohyodeoxycholic acid sodium 1 Publications Verification	Interleukin Related TNF Receptor	Inflammation/Immunology
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-162622

BET-IN-26	Epigenetic Reader Domain	Inflammation/Immunology
BET-IN-26 (compound 13a) is a potent, selective and orally active BD1 inhibitor with IC₅₀ values of 0.0055, 9.0 µM for BD1, BD2, respectively. BET-IN-26 decreases LPS (HY-D1056) induced serum levels of IL-6 and MCP-1 .

HY-146244

Agatolimod ODN 2006; PF-3512676; CpG 7909; ODN 7909	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Agatolimod (ODN 2006), a class B ODN (oligodeoxynucleotide), is a TLR9 agonist. Agatolimod is also an optimal CpG sequence for humans. Agatolimod stimulates very strong production of NO₂ and IL-6 in HD11 cells. Agatolimod can be used for breast cancer research. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3' .

HY-150740A

ODN 21595 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 21595 sodium is a Guanine-Modified TLR7 and TLR9 inhibitor. ODN 21595 sodium inhibits the release of IFN-α and IL-6 with no cytotoxic. ODN 21595 sodium reduces the expression of CD86 and HLA-DR. ODN 21595 sodium has the potential for the research of systemic lupus erythematosus (SLE) .

HY-123625

R-348 choline R-932348 choline	Interleukin Related JAK Syk	Inflammation/Immunology
R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection .

HY-150740

ODN 21595	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 21595 is a Guanine-Modified TLR7 and TLR9 inhibitor. ODN 21595 inhibits the release of IFN-α and IL-6 with no cytotoxic. ODN 21595 reduces the expression of CD86 and HLA-DR. ODN 21595 has the potential for the research of systemic lupus erythematosus (SLE) .

HY-N4061

Hedycoronen A	Interleukin Related	Inflammation/Immunology
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

HY-145846

iNOs-IN-1 1 Publications Verification	NO Synthase Interleukin Related	Inflammation/Immunology
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .

HY-149391

PROTAC BTK Degrader-6	PROTACs Btk	Inflammation/Immunology
PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC₅₀: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6) .

HY-168084

IL-17-IN-1	Interleukin Related	Inflammation/Immunology
IL-17-IN-1 (26) is an orally active IL-17 inhibitor, with IC₅₀ values of 0.013 μM and 0.004 μM for IL-17A and IL-6 release, respectively. IL-17-IN-1 (26) effectively reduces knee swelling in a rat arthritis model .

HY-P99316

Sirukumab CNTO-136	Interleukin Related	Inflammation/Immunology
Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to *IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6*. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis .

HY-153254

BMS905	Toll-like Receptor (TLR)	Inflammation/Immunology
BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC₅₀s: 0.7 and 3.2 nM respectively). BMS905 inhibits TLR7 or TLR8 induced IL-6 production in human/mouse whole blood. BMS905 can be used for research of lupus .

HY-N6927

Isoforskolin Coleonol B	TNF Receptor Interleukin Related	Inflammation/Immunology
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, *IL-6* and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis .

HY-N14325

Madindoline B	Interleukin Related	Infection
Madindoline B is an *IL-6* inhibitor. Madindoline B inhibits IL-6-dependent MH-60 cells and has no inhibitory effect on IL-6-independent MH-60 cells. In the presence of 0.1 U/mL IL-6, it inhibits IL-6-dependent MH-60 cells with an IC₅₀ of 30 μM. Madindoline B has no antimicrobial effect .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9315

Episappanol	Other Terpenoids Classification of Application Fields Leguminosae Terpenoids Caesalpinia sappan L. Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	TNF Receptor Interleukin Related
Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the *IL-6* and TNF-α secretion .

HY-N7275

Di-O-methyldemethoxycurcumin	Natural Products Classification of Application Fields Source classification Plants Curcuma longa Disease Research Fields Inflammation/Immunology Zingiberaceae	Interleukin Related
Di-O-methyldemethoxycurcumin, a curcuminoid analog, inhibits *IL-6* production with an EC₅₀ of 16.20 μg/mL. Anti-inflammatory and antioxidant properties .

HY-N7674

Angoline 2 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Source classification Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Interleukin Related STAT
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

HY-N2086

Ethyl palmitate 2 Publications Verification Ethyl hexadecanoate	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields	TNF Receptor Interleukin Related NF-κB
Ethyl palmitate (Ethyl hexadecanoate) is a CHIKV virus inhibitor with an EC₅₀ value of 0.0068 μM. Ethyl palmitate can reduce levels of TNF-α, *IL-6, and NF-κB* in endotoxemic rats, showing anti-inflammatory activity .

HY-N6927

Isoforskolin Coleonol B	Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields Pueraria montana (Lour.) Merr.	TNF Receptor Interleukin Related
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, *IL-6* and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis .

HY-N0633

Muscone 3 Publications Verification	Cardiovascular Disease Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	P-glycoprotein Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and *IL-6*), and ultimately improves cardiac function and survival rate .

HY-N3380

Linderaspirone A	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	PGE synthase Interleukin Related
Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 .

HY-N7674A

Angoline hydrochloride	Alkaloids Classification of Application Fields Source classification Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	STAT
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

HY-N4061

Hedycoronen A	Hedychium coronarium Koen. Structural Classification Terpenoids Source classification Diterpenoids Plants Zingiberaceae	Interleukin Related
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

HY-N14325

Madindoline B	Structural Classification Natural Products Microorganisms Source classification	Interleukin Related
Madindoline B is an *IL-6* inhibitor. Madindoline B inhibits IL-6-dependent MH-60 cells and has no inhibitory effect on IL-6-independent MH-60 cells. In the presence of 0.1 U/mL IL-6, it inhibits IL-6-dependent MH-60 cells with an IC₅₀ of 30 μM. Madindoline B has no antimicrobial effect .

HY-129113

α-Chaconine	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Source classification Plants Inflammation/Immunology Disease Research Fields	COX
α-Chaconine inhibits the expressions of COX-2, IL-1β, *IL-6, and TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N0405

Orientin 3 Publications Verification	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	TNF Receptor Interleukin Related
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of *IL-6, IL-1β* and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N8413

Chlojaponilactone B	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Chloranthus japonicus Sieb. Plants	Toll-like Receptor (TLR) Reactive Oxygen Species NF-κB
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α .

HY-N6927R

Isoforskolin (Standard)	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Pueraria montana (Lour.) Merr.	TNF Receptor Interleukin Related
Isoforskolin (Standard) is the analytical standard of Isoforskolin. This product is intended for research and analytical applications. Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis .

HY-N7652

Terminolic acid	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology	Bacterial
Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity .

HY-N0633R

Muscone (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	P-glycoprotein Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)
Muscone (Standard) is the analytical standard of Muscone. This product is intended for research and analytical applications. Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate .

HY-N0405R

Orientin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	TNF Receptor Interleukin Related
Orientin (Standard) is the analytical standard of Orientin. This product is intended for research and analytical applications. Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N12042

Taxamairin B	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus wallichiana var. mairei (Lemee & H. Léveillé) L. K. Fu & Nan Li	TNF Receptor PI3K Reactive Oxygen Species Interleukin Related
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and *IL-6) expression and the production of NO and ROS* in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice .

HY-129113R

α-Chaconine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Gramineae Source classification Plants	COX
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N7630

Rehmapicrogenin	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Inflammation/Immunology Disease Research Fields	NO Synthase COX
Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6 .

HY-N0604

Ginsenoside Rh1 4 Publications Verification Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related PPAR TNF Receptor Endogenous Metabolite
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, *IL-6, and IL-1β*.

HY-N0857

Deoxyandrographolide 1 Publications Verification	Andrographis paniculata (Burm. F.) Nees Acanthaceae Terpenoids Source classification Diterpenoids Plants	Interleukin Related
Deoxyandrographolide suppresses LPS induced increase in mRNA levels of iNOS as well as production of proinflammatory mediators TNF-α and IL-6. Deoxyandrographolide potentiates NGF-induced neurite outgrowth .

HY-N9891

12-Dehydrogingerdione 12-DHGD	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	NO Synthase Interleukin Related
12-Dehydrogingerdione is an inhibitor of NO Synthase. 12-Dehydrogingerdione signi?cantly inhibits LPS-stimulated production of NO, *IL-6* and PGE2 in Raw 264.7 cells .

HY-N13114

8-Gingerdione	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	Others
8-Gingerdione can be isolated from ginger (Zingiber officinale). 8-Gingerdione has no significant inhibitory effect on the production of inflammatory factors NO, TNF-α, and IL-6.

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Structural Classification Natural Products Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Interleukin Related Reactive Oxygen Species
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine *IL-6, and increases the anti-inflammatory cytokine IL-10* levels. Sodium thiocyanate also significantly reduces of ROS formation .

HY-N1949

Homoplantaginin 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	TNF Receptor NF-κB
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and *IL-6* mRNA expression, IKKβ and NF-κB phosphorylation.

HY-N4288

4-Methylesculetin 1 Publications Verification	Structural Classification Nicotiana tabacum L. Classification of Application Fields Source classification Coumarins Phenols Polyphenols Phenylpropanoids Solanaceae Plants Disease Research Fields Cancer	Glutathione Peroxidase Cathepsin Phosphatase
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases .

HY-N12743

Farobin A	Structural Classification Zea mays L. Flavonoids Flavones Gramineae Source classification Plants	Bacterial
Farobin A is a natural compound with antibacterial, antioxidant and anti-inflammatory activities. Farobin A against Streptococcus mutans ATCC 25175 and Streptococcus sobrinus ATCC 33478. Farobin A shows anti-inflammatory activity on cytokine IL-6 and TNF-α .

HY-N0710

alpha-Cyperone 2 Publications Verification α-Cyperone; (+)-α-Cyperone	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.

HY-111346

1-Linoleoyl Glycerol 1-Linoleoyl-rac-glycerol; 1-Monolinolein	Cardiovascular Disease Structural Classification Saururaceae Classification of Application Fields Saururus chinensis (Lour.) Baill. Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields	Phospholipase Apolipoprotein Interleukin Related
1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of *IL-6*) .

HY-N0029

Forsythoside B 5+ Cited Publications	Structural Classification Oleaceae Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields	TNF Receptor NF-κB
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, *IL-6, IκB* and modulate NF-κB.

HY-N0604R

Ginsenoside Rh1 (Standard) Prosapogenin A2 (Standard); Sanchinoside B2 (Standard); Sanchinoside Rh1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related PPAR TNF Receptor Endogenous Metabolite
Ginsenoside Rh1 (Standard) is the analytical standard of Ginsenoside Rh1. This product is intended for research and analytical applications. Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-N3552

Catalposide	Other Terpenoids Structural Classification Catalpa ovata G. Don Monophenols Classification of Application Fields Terpenoids Source classification Phenols Bignoniaceae Plants Inflammation/Immunology Disease Research Fields	NF-κB
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-N1949R

Homoplantaginin (Standard)	Structural Classification Flavonoids Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants	TNF Receptor NF-κB
Homoplantaginin (Standard) is the analytical standard of Homoplantaginin. This product is intended for research and analytical applications. Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.

HY-N0569

Madecassic acid 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants Inflammation/Immunology Disease Research Fields	NO Synthase COX TNF Receptor Interleukin Related
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and *IL-6* inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .

HY-N1356

Reticuline	Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Disease Research Fields	JAK STAT NF-κB Endogenous Metabolite
Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3 . Reticuline exhibits cardiovascular effects .

HY-N3421

Koaburaside	Structural Classification Eucommia ulmoides Oliver Source classification Eucommiaceae Plants Saccharides Monosaccharides	Interleukin Related TNF Receptor Influenza Virus
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of *IL-6* and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-N0314

Pectolinarin 2 Publications Verification	Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Source classification Phenols Lupinus angustifolius L. Plants Compositae Inflammation/Immunology Disease Research Fields	Interleukin Related Prostaglandin Receptor Apoptosis
Pectolinarin possesses anti-inflammatory activity . Pectolinarin inhibits secretion of *IL-6* and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway .

HY-110151

Bengamide B	Structural Classification Alkaloids Other Alkaloids Marine natural products Source classification Sponge	NF-κB Interleukin Related
Bengamide B is an inhibitor for NF-κB with an IC₅₀ of 85 nM. Bengamide B inhibits LPS (HY-D1056)-induced expression of TNF-α, IL-6 and MCP-1, exhibits anti-inflammatory activity. Bengamide B exhibits antitumor efficacy (IC₅₀ for HCT-116 is 2 nM) .

HY-128731

5-Methoxy-DL-tryptophan 1 Publications Verification DL-5-MTP	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Interleukin Related
5-Methoxy-DL-tryptophan is a metabolite. 5-Methoxy-DL-tryptophan reduces LPS (HY-D1056)-induced release of *IL-6*. 5-Methoxy-DL-tryptophan has anti-inflammatory effects. 5-Methoxy-DL-tryptophan can be used in the study of atherosclerosis .

HY-N2572

Nepetin 6-Methoxyluteolin	Structural Classification Classification of Application Fields Flavones Source classification Plants Compositae Flavonoids Lespedeza juncea (L. f.) Pers. Labiatae Cassia Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Interleukin Related
Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits *IL-6, IL-8* and MCP-1 secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells .

HY-W041489R

Chelidonic acid (Standard)	Structural Classification Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Papaveraceae	NF-κB Caspase
Chelidonic acid (Standard) is the analytical standard of Chelidonic acid. This product is intended for research and analytical applications. Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 . Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM .

HY-N6246

Asperulosidic Acid	Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Morinda officinalis How Inflammation/Immunology Disease Research Fields	NF-κB ERK
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities . ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways .

HY-N4126

6-Demethoxytangeretin	Structural Classification Neurological Disease Classification of Application Fields Flavones Source classification Rutaceae Plants Citrus reticulata Blanco Flavonoids other families Inflammation/Immunology Disease Research Fields Cancer	Anaplastic lymphoma kinase (ALK) p38 MAPK Interleukin Related ERK JNK JAK STAT Akt
6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of *IL-6* and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons .

HY-N0029R

Forsythoside B (Standard)	Structural Classification Oleaceae Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants	TNF Receptor NF-κB
Forsythoside B (Standard) is the analytical standard of Forsythoside B. This product is intended for research and analytical applications. Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.

HY-N9965

2'-Fucosyllactose 2'-FL	Infection Structural Classification Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides	TNF Receptor Interleukin Related
2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines .

HY-N0710R

alpha-Cyperone (Standard)	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants Endogenous metabolite	Endogenous Metabolite
alpha-Cyperone (Standard) is the analytical standard of alpha-Cyperone. This product is intended for research and analytical applications. alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.

HY-N2007

Veratric acid 3,4-Dimethoxybenzoic acid	Cardiovascular Disease Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields	COX Reactive Oxygen Species
Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities . Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling . Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation .

HY-N0314R

Pectolinarin (Standard)	Structural Classification Monophenols Flavonoids Flavones Source classification Phenols Lupinus angustifolius L. Plants Compositae	Interleukin Related Prostaglandin Receptor Apoptosis
Pectolinarin (Standard) is the analytical standard of Pectolinarin. This product is intended for research and analytical applications. Pectolinarin possesses anti-inflammatory activity . Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway .

Cat. No.	Product Name	Chemical Structure

HY-B0141S

Estradiol-d3
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-B0260S3

Methylprednisolone-d7
Methylprednisolone-d₇ is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

HY-13740S

Resiquimod-d5 1 Publications Verification
Resiquimod-d₅ is deuterium labeled Resiquimod. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α .

HY-B0141S2

Estradiol-d5
Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S3

Estradiol-d2
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S1

Estradiol-d4 1 Publications Verification
Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S6

Estradiol-d2-1
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3][4].

HY-B0260S

Methylprednisolone-d3
Methylprednisolone-d₃ is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

HY-B0260S2

Methylprednisolone-d4
Methylprednisolone-d₄ is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

HY-B0260S4

Methylprednisolone-d2
Methylprednisolone-d₂ is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3][4].

HY-B0141S4

Estradiol-13C6
Estradiol- ¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S5

Estradiol-13C2
Estradiol- ¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-114360AS1

Taurohyodeoxycholic acid-d4 sodium
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-128423AS

Tylvalosin-d9
Tylvalosin-d₉ (Acetylisovaleryltylo?sin-d₉) is the deuterium labeled Tylvalosin (HY-128423A) . Tylvalosin is a third-generation macrolide, with anti-inflammatory property. Tylvalosin decreases the levels of IL-8, IL-6, IL-1β, PGE2, TNF-α and NO, and reduces the inflammatory cells recruitment and activation in mouse acute lung injury model .

HY-N2007S

Veratric acid-d6

Veratric acid-d₆ is deuterium labeled Veratric acid. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].

HY-W026772S1

Fluorene-d8

Fluorene-d₈ is the deuterium labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .

HY-B0667S1

Balsalazide-d4
Balsalazide-d₄ is deuterium labeled Balsalazide. Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

HY-A0031S

Bazedoxifene-d4

Bazedoxifene-d₄ is deuterium labeled Bazedoxifene. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

HY-A0031S2

Bazedoxifene-d4 acetate

Bazedoxifene-d₄ (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].

HY-113066S2

Guanosine 5'-diphosphate-d13 dilithium

Guanosine 5'-diphosphate-d₁₃ (GDP-d₁₃) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S1

Guanosine 5'-diphosphate-13C10 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀ (GDP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S3

Guanosine 5'-diphosphate-13C10,15N5 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀, ¹⁵N₅ (GDP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

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