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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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MCF-7 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) ADC Cytotoxin (1) Akt (6) Aldehyde Dehydrogenase (ALDH) (2) AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Antibiotic (5) AP-1 (1) Apoptosis (119) Aryl Hydrocarbon Receptor (2) ATM/ATR (1) Aurora Kinase (1) Autophagy (7) Bacterial (12) Bcl-2 Family (10) Biochemical Assay Reagents (2) c-Kit (1) Carbonic Anhydrase (6) Casein Kinase (2) Caspase (9) CDK (17) Ceramidase (1) Checkpoint Kinase (Chk) (2) Cholinesterase (ChE) (2) COX (2) CXCR (1) Cytochrome P450 (8) Deubiquitinase (1) Dihydrofolate reductase (DHFR) (4) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (2) DNA Methyltransferase (1) DNA-PK (1) DNA/RNA Synthesis (4) E3 Ligase Ligand-Linker Conjugates (1) EGFR (26) Endogenous Metabolite (10) Ephrin Receptor (1) Epigenetic Reader Domain (3) ERK (1) Estrogen Receptor/ERR (29) FAK (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (1) FGFR (2) Fluorescent Dye (1) Fungal (9) Glucosidase (1) GLUT (1) Glutaminase (1) Glutathione S-transferase (1) GSK-3 (1) HDAC (8) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (3) Histone Demethylase (2) Histone Methyltransferase (4) HIV (1) HSP (8) IGF-1R (2) Influenza Virus (1) Interleukin Related (3) Isotope-Labeled Compounds (4) JAK (2) Leukotriene Receptor (2) Ligands for E3 Ligase (2) Lipoxygenase (1) LXR (1) MARK (1) MDM-2/p53 (6) MicroRNA (1) Microtubule/Tubulin (18) Mitochondrial Metabolism (3) MMP (1) Molecular Glues (1) Monocarboxylate Transporter (1) Mps1 (1) mTOR (4) Mucin (1) MyD88 (1) Necroptosis (2) NF-κB (5) NO Synthase (4) Orthopoxvirus (5) P-glycoprotein (5) Paraptosis (1) Parasite (4) PARP (9) PDGFR (1) Phosphatase (1) PI3K (10) Pim (6) PKC (6) Polo-like Kinase (PLK) (1) Progesterone Receptor (2) PROTACs (11) Proteasome (3) Raf (4) Reactive Oxygen Species (15) RET (1) Reverse Transcriptase (1) SARS-CoV (1) Sigma Receptor (1) Sirtuin (1) SNIPERs (1) Src (2) STAT (1) Steroid Sulfatase (2) TGF-β Receptor (1) Thymidylate Synthase (1) TNF Receptor (3) Toll-like Receptor (TLR) (1) Topoisomerase (23) Trk Receptor (1) Tyrosinase (1) VD/VDR (3) VEGFR (22) Xanthine Oxidase (1) γ-secretase (1)
By Research Areas:	Cancer (387) Cardiovascular Disease (1) Endocrinology (14) Infection (33) Inflammation/Immunology (15) Metabolic Disease (6) Neurological Disease (7)
Click Chemistry:	Azide (1)
Oligonucleotides:	Aptamers (2)

429

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4010

Iriflophenone	Others	Cancer
Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation .

HY-134964

CTB 3 Publications Verification	Histone Acetyltransferase Apoptosis	Neurological Disease Cancer
CTB is a potent p300 histone acetyltransferase activator . CTB can effectively induce apoptosis in MCF-7 cells .

HY-13686

PQ401 2 Publications Verification	IGF-1R Apoptosis	Cancer
PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC₅₀ of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC₅₀, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis .

HY-100219

CB1151	VD/VDR	Cancer
CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC₅₀ value of 0.82 nM .

HY-153700

Estrogen receptor modulator 8	Estrogen Receptor/ERR	Endocrinology
Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC₅₀=0.437 nM, MCF-7 cells). Estrogen receptor modulator 8 inhibits MCF-7 cells proliferation with an IC₅₀ value of 0.1 nM .

HY-163126

AChE-IN-52	Cholinesterase (ChE)	Cancer
AChE-IN-52 (compound A6) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-52 shows antitumor efficacy, especially against breast cancer MCF-7 cells. AChE-IN-52 significantly disrupts the amino acid metabolism and inhibits migration of MCF-7. AChE-IN-52 plays anticancer role by regulating Best1 and HIST1H2BJ .

HY-147887

Tubulin inhibitor 28	Microtubule/Tubulin	Cancer
Tubulin inhibitor 28 (compound 2g) is a potent tubulin inhibitor with an IC₅₀ value of 1.2 µM. Tubulin inhibitor 28 shows anti-proliferative activity for MCF-7 cells .

HY-162695

Antitumor agent-168	Microtubule/Tubulin	Cancer
Antitumor agent-168 (compound 21b) disrupts the microtubule network in tumor cells leading to G2/M cell cycle arrest and apoptosis induction. Antitumor agent-168 inhibits MCF-7 growth with an IC₅₀ value of 1.4 nM .

HY-107550

HDAC6-IN-7	HDAC	Cancer
TCS HDAC6 20b is a HDAC6-selective inhibitor. TCS HDAC6 20b blocks the growth of estrogen receptor α-positive breast cancer MCF-7 cells .

HY-147882

Anti-MRSA agent 6	Bacterial	Infection
Anti-MRSA agent 6 (compound 3q6) is a potent *anti-methicillin-resistant Staphylococcus aureus* (anti-MRSA)** agent. Anti-MRSA agent 6 shows low cytoxicity for MCF-7, A549 cells .

HY-N10959

4,15-Isoatriplicolide methylacrylate	Others	Cancer
4,15-Isoatriplicolide methylacrylate is a germacrane-type sesquiterpene lactone. 4,15-Isoatriplicolide methylacrylate also is a cytotoxic agent. 4,15-Isoatriplicolide methylacrylate has cytotoxic activity for MCF-7 human breast cancer cell line .

HY-137099

Genistein 7-sulfate	Others	Endocrinology
Genistein 7-sulfate is a metabolite of genistein that can reduce the activity of estrogen agonists in MCF-7 cells. Genistein 7-sulfate can promote the growth of MCF-7 cells at concentrations of 10 μM and above .

HY-137099A

Genistein 7-sulfate sodium	Others	Endocrinology
Genistein 7-sulfate sodium is a metabolite of genistein that can reduce the activity of estrogen agonists in MCF-7 cells. Genistein 7-sulfate sodium can promote the growth of MCF-7 cells at concentrations of 10 μM and above .

HY-146988

hCAIX/XII-IN-1	Carbonic Anhydrase Apoptosis	Cancer
hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the K_I values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells .

HY-155348

Ru3	PARP	Cancer
Ru3 is a poly(ADP-ribose) polymerase 1 inhibitor. Ru3 induces apoptosisin MCF-7 cells by multiple modes, inclusive of inducing DNA damage, suppressing DNA damage repair, disturbing cell cycle distribution, decreasing the mitochondrial membrane potential, and increasing the intracellular reactive oxygen species levels .

HY-144792

Bcl-2-IN-7	Bcl-2 Family MDM-2/p53 Caspase Apoptosis	Cancer
Bcl-2-IN-7 (compound 6) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC₅₀ values of 20.17, 22.64, 45.57, and 51.50 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively .

HY-144791

Bcl-2-IN-6	Bcl-2 Family MDM-2/p53 Caspase Apoptosis	Cancer
Bcl-2-IN-6 (compound 10) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC₅₀ values of 20.91, 22.30, 42.29, and 48.00 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively .

HY-153789

PI5P4Kγ-IN-1	Others	Cancer
PI5P4Kγ-IN-1 (compound 2) is a selective PI5P4Kγ inhibitor. PI5P4Kγ-IN-1 can be used to signal mTORC1 in MCF-7 breast cancer cells and further characterize PI5P4Kγ in the cells .

HY-P5033

Cyclo(Gly-His)	Bacterial	Cancer
Cyclo(Gly-His) is a liposome-encapsulated cyclic dipeptide with antimicrobial and anticancer activity. Cyclo(Gly-His) has cytotoxicity for HeLa and MCF-7 cell with IC₅₀ values of 1.699 mM and 0.358 mM, respectively. Cyclo(Gly-His) can be used for the research of drug delivery systems .

HY-N11973

5,7-Dimethoxy-2,3-phenanthrenediol	Others	Cancer
5,7-Dimethoxy-2,3-phenanthrenediol is a compound with estrogenic activity. 5,7-Dimethoxy-2,3-phenanthrenediol increases the proliferation of MCF-7 cell and the expression of ERβ in the MCF-7 cell line .

HY-147888

Tubulin inhibitor 29	Microtubule/Tubulin	Cancer
Tubulin inhibitor 29 (compound 3c) is a potent tubulin inhibitor with an IC₅₀ value of 1.2 µM. Tubulin inhibitor 29 shows antiproliferative effects with an IC₅₀ value of 7.5 µM for MCF-7 cells. Tubulin inhibitor 29 inhibits tubulin assembly and bounds in the colchicine site .

HY-115947

Anticancer agent 33	Others	Cancer
Anticancer agent 33 (compound 3), a Squamocin and Bullatacin derivative, is a potent anticancer agent. Anticancer agent 33 shows high potency to inhibit 4T1 breast cancer cell line (A549, HeLa, HepG2 and MCF-7 cells) growth with IC₅₀s of 1.9-5.4 µM .

HY-144637

Autophagy inducer 2	Apoptosis Autophagy	Cancer
Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC₅₀ value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer .

HY-14585

Estrone O-sulfamate Estrone 3-O-sulfamate	Steroid Sulfatase	Cancer
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent steroid sulfatase (STS) inhibitor. Estrone O-sulfamate has inhibitory activity for STS in a placental microsomes (P.M.) preparation and in MCF-7 cells with IC₅₀ values of 18 nM and 0.83 nM, respectively. Estrone O-sulfamate can be used for the research of cancer .

HY-169122

LLC1	Others	Cancer
LLC1 is an amiloride (HY-B0285) derivative with cytotoxicity against breast cancer cells, particularly those resistant to treatment. The IC₅₀ values of LLC1 for MCF7, MCF7 MX-100, MCF7 TS, MCF7 TR-1, and MCF7 TR-5 are 13, 12, 25, 26, and 19 mM, respectively. LLC1 shows potential for research in the field of cancer therapy .

HY-N10871

Neocryptomerin	Others	Cancer
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell .

HY-161858

EpskA21	PI3K Akt Apoptosis	Cancer
EpskA21 is an inhibitor for PI3K/AKT signaling pathway, and inhibits the proliferation of cancer cells MCF-7, A549, MIA-PaCa-2, Panc-1 and HepG2, with IC₅₀ of 1.3-7.24 μM. EpskA21 inhibits the cell migration, arrests the cell cycle at G2/M (MCF-7) and S (MIA-PaCa-2) phase, and induces apoptosis in MCF-7 and MIA-PaCa-2. EpskA21 causes the mitochondrial dysfunction .

HY-144306

ERα degrader 4	Estrogen Receptor/ERR Apoptosis	Cancer
ERα degrader 4 is an excellent and selective estrogen receptor α (ERα) degrader (IC₅₀ of 0.31, 0.41 and 0.48 μM in MDA-MB-231, MCF-7 and MCF-7/ADR cells, respectively). ERα degrader 4 has potent inhibitory activity against MCF-7 cell lines. ERα degrader 4 is a potential SERDs candidate for the research of breast cancer .

HY-162000

hCAIX/XII-IN-13	Apoptosis	Cancer
hCAIX/XII-IN-13 is an inhibitor of human carbonic anhydrases (hCA). hCAIX/XII-IN-13 shows good inhibitory activity against the tumor-related CA subtypes IX and XII, with K_i values of 0.08 µM and 0.06 µM, respectively. Under hypoxic conditions, hCAIX/XII-IN-13 can restore the cytotoxicity of Doxorubicin (HY-15142A) on MCF-7 cells, increasing G₂/M phase cell cycle arrest and apoptosis .

HY-101989

Tubulin polymerization-IN-24	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly .

HY-145866

Antiproliferative agent-3	Others	Cancer
Antiproliferative agent-3 (comp 4) shows the highest potency for MCF-7 cells (IC₅₀ = 0.19 nM) .

HY-147913

PI3K/Akt/mTOR-IN-3	PI3K Akt mTOR Apoptosis	Cancer
PI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC₅₀ values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest .

HY-153469

Benzyl DC-81	ADC Cytotoxin	Cancer
Benzyl DC-81 (Compound 6a) is an anticancer agent with antiproliferative activity against A375 and MCF-7 cells .

HY-B0543

Allylthiourea Thiosinamine; N-Allylthiourea	Reactive Oxygen Species	Cancer
Allylthiourea can selectively inhibit the oxidation of ammonia. Allylthiourea is commonly used to inhibit nitrification by targeting ammonia monooxygenase and chelating copper in the active site to suppress its activity. Allylthiourea also exhibits anticancer activity, showing cytotoxicity against the MCF-7 cell line with an IC₅₀ of 5.22 mM. Allylthiourea can be utilized in research related to micropollutant biodegradability and cancer studies .

HY-116377

DU-14	Steroid Sulfatase	Neurological Disease
DU-14 is a potent steroid sulfatase inhibitor with an IC₅₀ of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC₅₀ = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity .

HY-148368

CYD-4-61	Bcl-2 Family Apoptosis	Cancer
CYD-4-61 is a novel Bax activator used for breast cancer research. CYD-4-61 inhibits triple-negative breast cancer MDA-MB-231 and ER-positive breast cancer MCF-7 cell lines proliferation. CYD-4-61 activates Bax protein to induce cytochrome c release and regulate apoptotic biomarkers, leading to cancer cell apoptosis .

HY-155841

Tubulin polymerization-IN-46	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-46 (compound 9q) is a microtubule/Tubulin inhibitor that inhibits tubulin polymerization and induces apoptosis. Tubulin polymerization-IN-46 inhibits mitosis and arrests MCF-7 cells in the G2/M phase. Tubulin polymerization-IN-46 has anti-proliferative activity against MCF-7 breast cancer cells with an IC₅₀ of 10 nM .

HY-13668

Lomeguatrib 5+ Cited Publications PaTrin-2	DNA Methyltransferase	Cancer
Lomeguatrib is a O ⁶-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC₅₀s of 9 nM in cell-free assay and ～6?nM in MCF-7 cells.

HY-155177

CDK9-IN-27	CDK	Cancer
CDK9-IN-27 (Compound 6a) is a CDK9 inhibitor (IC₅₀s: 0.424 μM). CDK9-IN-27 induces apoptosis and cell cycle arrest at S stage. CDK9-IN-27 has cytotoxic action against HepG2, HCT-116 and MCF-7 cell lines, with IC₅₀s of 10.31-40.34 μM. CDK9-IN-27 can be used for cancer research .

HY-158388

Anticancer agent 215	Topoisomerase	Cancer
Anticancer agent 215 (1) is a Camptothecin compound, with IC₅₀ values of 5.2 nM and 8.2 nM in MCF-7 cells and MDA-MB-231 cells, respectively .

HY-158389

Anticancer agent 216	Topoisomerase	Cancer
Anticancer agent 216 (34A) is a Camptothecin compound, with IC₅₀ values of 9.6 nM and 11.6 nM in MCF-7 cells and MDA-MB-231 cells, respectively .

HY-158387

Anticancer agent 214	Topoisomerase	Cancer
Anticancer agent 214 (2) is a Camptothecin compound, with IC₅₀ values of 2.6 nM and 15.7 nM in MCF-7 cells and MDA-MB-231 cells, respectively .

HY-N5103

Genistein 7,4'-di-O-β-D-glucoside	Others	Endocrinology
Genistein 7,4'-di-O-β-D-glucoside is a natural product with significantly estrogenic proliferative effect in MCF-7 cells .

HY-147967

EGFR-IN-63	EGFR	Cancer
EGFR-IN-63 is an EGFR inhibition (IC₅₀: 0.096 μM) and it has anticancer activity in MCF-7 cells (IC₅₀: 2.49 μM).

HY-N3042

Platyphyllonol Platyphyllone	Others	Cancer
Platyphyllonol (Platyphyllone) can be isolated from A. japonica. Platyphyllonol shows cytotoxic effects on MCF-7 cells with IC₅₀ values of 46.9 μg/mL .

HY-158390

Anticancer agent 217	Topoisomerase	Cancer
Anticancer agent 217 (35B) is a Camptothecin compound, with IC₅₀ values of 6.2 nM and 7.1 nM in MCF-7 cells and MDA-MB-231 cells, respectively .

HY-147853

B-Raf IN 8	Raf	Cancer
B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC₅₀ of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC₅₀ values of 9.78, 13.78, 18.52 and 29.85 µM .

HY-163281

FSY-OSO2F	Fluorescent Dye	Cancer
FSY-OSO2F shows an uptake in MCF-7 cells through the regulation of L-Tyr, ASC, and ASC2 transporters. FSY-OSO2F can be used as a PET tracer, when labeled with ¹⁸F, and exhibits good uptake and good contrast in MCF-7 and 22Rv1 subcutaneous tumors .

HY-132247B

(S)-ErSO	Others	Cancer
(S)-ErSO is the dextrorotatory enantiomer of ErSO. (S)-ErSO is inactive in MCF-7 cells (from patent WO2020009958A1, compound (s)-105) .

HY-N8679

Physalin C	Endogenous Metabolite	Cancer
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

Cat. No.	Product Name	Type

HY-B0812

5-Sulfosalicylic acid dihydrate SSA dihydrate	Chelators
5-Sulfosalicylic acid dihydrate is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid dihydrate is effective against the breast cancer cell line, MCF-7, with less toxicity . 5-Sulfosalicylic acid dihydrate has antioxidant activities .

HY-113319

β-D-Fructose	Carbohydrates
β-D-Fructose is a β-fruit sugar that can be produced by the hydrolysis of sucrose. β-D-Fructose can be used as a sweetness potentiator. β-D-Fructose can be designed as a units of antiproliferative agents against breast (MCF-7) and colon (MDST8) cancer cell lines .

Cat. No.	Product Name	Target	Research Area

HY-P5755

SWELYYPLRANL-NH2	Peptides	Cancer
SWELYYPLRANL-NH2 is an E-cadherin and N-cadherin antagonist. SWELYYPLRANL-NH2 inhibits phage clone binding to E- or N-cad/Fc chimeric protein (IC₅₀: 0.7 and 0.09 μM respectively). SWELYYPLRANL-NH2 inhibits cell aggregation. SWELYYPLRANL-NH2 can be used to promote drug delivery through epithelial and endothelial permeability barriers .

HY-P4210

Sulanemadlin ALRN-6924; MP-4897	MDM-2/p53	Cancer
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .

HY-120234

Z-LLNle-CHO Z-Leu-Leu-Nle-CHO; GSII	γ-secretase Proteasome Apoptosis	Cancer
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia .

HY-P5033

Cyclo(Gly-His)	Bacterial	Cancer
Cyclo(Gly-His) is a liposome-encapsulated cyclic dipeptide with antimicrobial and anticancer activity. Cyclo(Gly-His) has cytotoxicity for HeLa and MCF-7 cell with IC₅₀ values of 1.699 mM and 0.358 mM, respectively. Cyclo(Gly-His) can be used for the research of drug delivery systems .

HY-P5956

Ac-AAVALLPAVLLALLAP-LEHD-CHO	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-LEHD-CHO is an inhibitor of caspases 4, 5 and 9. Ac-AAVALLPAVLLALLAP-LEHD-CHO shows protective effects upon Neocarzinostatin (HY-111183)-treated MCF-7 cells .

HY-P4523

FA-Ala-Arg	Endogenous Metabolite	Endocrinology
FA-Ala-Arg is a dipeptide with furylacryloyl group. FA-Ala-Arg breaks down to produce arginine. While cell-surface Carboxypeptidase-D (CPD) also increases intracellular Arg, which is converted to nitric oxide (NO). FA-Ala-Arg enhances NO production in MCF-7 cells. FA-Ala-Arg also increases the cell survival of prolactin (PRL)-treated cells, PRL regulates CPD mRNA levels in cells .

HY-P10393

ERα17p ERα (295-311)	Apoptosis	Cancer
ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D, and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathways. ERα17p inhibits proliferations of breast cancer cells, induces apoptosis, and inhibits tumor growth in mouse models .

HY-P5755A

SWELYYPLRANL-NH2 TFA	Peptides	Cancer
SWELYYPLRANL-NH2 TFA is an E-cadherin and N-cadherin antagonist. SWELYYPLRANL-NH2 TFA inhibits phage clone binding to E- or N-cad/Fc chimeric protein (IC₅₀: 0.7 and 0.09 μM respectively). SWELYYPLRANL-NH2 TFA inhibits cell aggregation. SWELYYPLRANL-NH2 can be used to promote drug delivery through epithelial and endothelial permeability barriers .

HY-168095

CXCR4 antagonist 10	CXCR	Cancer
CXCR4 antagonist 10 (compound 21) is a potent antagonist of CXCR4, with the IC₅₀ of 7.8 nM. CXCR4 antagonist 10 plays an important role in cancer research .

Cat. No.	Product Name	Target	Research Area

HY-P99605

Cinrebafusp alfa PRS 343	EGFR TNF Receptor	Cancer
Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (K_d=0.3 nM) and human monomeric CD137 (4-1BB; K_d=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4010

Iriflophenone	Iridaceae Classification of Application Fields Thymelaeaceae Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Aquilaria sinensis (Lour.) Spreng. Cancer	Others
Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation .

HY-N10871

Neocryptomerin	Structural Classification Flavonoids Source classification Taxodiaceae Plants Cunninghamia lanceolata var. konishii Biflavones	Others
Neocryptomerin, a biflavonoid, shows inhibitory activity against U251, MCF-7, HeLa cell .

HY-N2198

Podocarpusflavone A	Structural Classification Flavonoids Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Plants Garcinia subelliptica Biflavones Disease Research Fields Cancer	Topoisomerase Apoptosis
Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor agents .

HY-N10959

4,15-Isoatriplicolide methylacrylate	Structural Classification Terpenoids Andira inermis (W.Wright) DC. Sesquiterpenes Source classification Plants Compositae	Others
4,15-Isoatriplicolide methylacrylate is a germacrane-type sesquiterpene lactone. 4,15-Isoatriplicolide methylacrylate also is a cytotoxic agent. 4,15-Isoatriplicolide methylacrylate has cytotoxic activity for MCF-7 human breast cancer cell line .

HY-N11973

5,7-Dimethoxy-2,3-phenanthrenediol	Structural Classification Dioscorea polystachya Turczaninow Source classification Phenols Polyphenols Plants Dioscoreaceae	Others
5,7-Dimethoxy-2,3-phenanthrenediol is a compound with estrogenic activity. 5,7-Dimethoxy-2,3-phenanthrenediol increases the proliferation of MCF-7 cell and the expression of ERβ in the MCF-7 cell line .

HY-N5103

Genistein 7,4'-di-O-β-D-glucoside	Flavonoids Monophenols Classification of Application Fields Leguminosae Source classification Ammopiptanthus nanus (M. Pop.) Cheng f. Phenols Plants Disease Research Fields Endocrinology Isoflavones	Others
Genistein 7,4'-di-O-β-D-glucoside is a natural product with significantly estrogenic proliferative effect in MCF-7 cells .

HY-N3042

Platyphyllonol Platyphyllone	Structural Classification Source classification Phenols Polyphenols Lepidoziaceae Bazzania serrulatioides Horik. Plants	Others
Platyphyllonol (Platyphyllone) can be isolated from A. japonica. Platyphyllonol shows cytotoxic effects on MCF-7 cells with IC₅₀ values of 46.9 μg/mL .

HY-N8679

Physalin C	Structural Classification Cardiacglycosides Source classification Physalis angulata L. Plants Solanaceae Steroids	Endogenous Metabolite
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-W747516

Butylcycloheptylprodigiosin	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Antibiotic
Butylcycloheptylprodigiosin is the secondary metabolite produced by some bacteria, such as Streptomyces. Butylcycloheptylprodigiosin is a red-pigmented antibiotic and exhibits cytotoxicity against cancer cell MCF-7 and HDF .

HY-N2887

Araliadiol	Structural Classification Natural Products Classification of Application Fields Aralia cordata Thunb. Source classification Plants Disease Research Fields Araliaceae Cancer	Others
Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC₅₀ value of 6.41 μg/mL .

HY-N10305

Clionamine B	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Autophagy
Clionamine B is an autophagy stimulating aminosteroid isolated from the sponge Cliona celata. Clionamine B strongly stimulates autophagy in human breast cancer MCF-7 cells .

HY-N2863

Goniothalenol	Goniothalamus calvicarpus Craib Structural Classification Natural Products Source classification Plants Annonaceae	Others
Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines .

HY-N7464

Jolkinolide E	Structural Classification Terpenoids Source classification Euphorbia rapulum Kar. et Kir. Diterpenoids Euphorbiaceae Plants	Others
Jolkinolide E is a casbane diterpenoid from the roots of Euphorbia rapulum. Jolkinolide E shows weak selective activity against HepG2, MCF-7, and C6 cell lines .

HY-N9391

7,3′,5′-Trihydroxyflavanone	Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Dalbergia sissoo Plants Disease Research Fields Cancer	Apoptosis
7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, induces the apoptotic cell death of MCF-7 cells by increasing Bax expression level. 7,3′,5′-Trihydroxyflavanone also exhibits antioxidant activity .

HY-N6990

Anhydrosecoisolariciresinol	Structural Classification other families Classification of Application Fields Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Others
Anhydrosecoisolariciresinol is from the flower of Wedelia biflora, has anti-tumor activities . Anhydrosecoisolariciresinol decreases the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines .

HY-N3443

Jolkinol A	Structural Classification Terpenoids Source classification Euphorbia peplus Linn. Diterpenoids Euphorbiaceae Plants	Others
Jolkinol A is a natural product that can be found in Euphorbia pubescens. Jolkinol A inhibits cell growth with GI₅₀s of 95.3, 57.3, >100 µM for MCF-7, NCI-460, SF-268 cells, respectively .

HY-22024

5-Hydroxyflavone	Flavonoids Monophenols other families Classification of Application Fields Flavones Source classification Phenols Plants Disease Research Fields Cancer	Others
5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells .

HY-N8859

Isoiridogermanal 16-Hydroxyiridal	Structural Classification Natural Products Source classification Lridaceae Plants	Others
Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against *MCF-7* and C32 cell lines.

HY-113796

Kopsoffinol	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Kopsia pauciflora Hook.f. Plants	Others
Kopsoffinol, a bisindole alkaloid, shows in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells .

HY-N7654

(-)-Epipodophyllotoxin	Structural Classification other families Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI₅₀s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro .

HY-N10846

Neotriptonoterpene	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.	Others
Neotriptonoterpene, a compound isolated from T. regelii, shows weak cytotoxic activity against A2780, HepG2 and MCF-7 cells with IC₅₀ values of 65.80, 35.45 and 64.80 µM respectively .

HY-N3316

Martynoside	Simple Phenylpropanols Labiatae Source classification Phenols Polyphenols Ligularia muliensis Hand.-Mazz. Phenylpropanoids Plants	Others
Martynoside protects ex vivo bone marrow cells from 5-fluorouracil (5-FU)-induced cell death and inflammation response by down-regulating the TNF signaling pathway .Martynoside is a potent antiestrogen in MCF-7 cells, increasing IGFBP3 levels

HY-N11438

3'-Hydroxymirificin	Structural Classification Flavonoids Flavones Leguminosae Source classification Pueraria montana (Loureiro) Merrill Plants	Estrogen Receptor/ERR
3'-Hydroxymirificin (compound 3) is a naural compound that can be isolated from Pueraria lobata roots. 3'-Hydroxymirificin (compound 3) possesses estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-N3261

Methyllinderone	Structural Classification Flavonoids Source classification Lindera erythrocarpa Makino Plants Lauraceae Other Flavonoids	AP-1 ERK STAT
Methyllinderone is an inhibitor of AP-1/STAT/ERK. Methyllinderone has anti-inflammatory effect. Methyllinderone reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Methyllinderone can be used in study breast cancer metastasis .

HY-N11919

Anticancer agent 149	Structural Classification Source classification Phenols Polyphenols Plants Dioscorea membranacea Pierre ex Prain & Burkill Dioscoreaceae	Others
Anticancer agent 149 (compound 3) is an anticancer agent isolated from the rhizome of Dioscorea dioscorea (DM). Anticancer agent 149 exhibits selective cytotoxic activity against MCF-7 cells (IC₅₀=31.41 μM) .

HY-N4227

Conicasterol	Structural Classification Natural Products Animals Source classification	Others
Conicasterol is a 4-mercaptosteroid with significant cytotoxic activity. Conicasterol showed an IC50 value of 6.23 μg/mL in a test on a human breast adenocarcinoma cell line (MCF-7). Conicasterol's antitumor activity makes it a potential bioactive lead molecule .

HY-N7302

Anthracophyllone	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Anthracophyllone is an aristolane sesquiterpene that can be isolated from the mushroom Anthracophyllum. Anthracophyllone has cytotoxicity against MCF-7, KB, NCI-H187, Vero cells (IC₅₀: 32.97, 18.02, 15.17, 18.06 μM) .

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-N3000

6-Methoxydihydrosanguinarine	Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Papaveraceae Cancer	Others
6-Methoxydihydrosanguinarine is an lkaloid isolated from the fruits of M.cordata. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC₅₀ values of 0.61 μM and 0.54 μM, respectively .

HY-N1252

Scillascillin	Structural Classification Source classification Phenols Polyphenols Plants Barnardia japonica (Thunberg) Schultes & J. H. Schultes Asparagaceae Juss.	Others
Scillascillin (compound 10) is a homoisoflavanone. Scillascillin can be isolated from S. scilloides. Scillascillin shows anticancer activity towards MCF-7 (breast cancer) and DU-145 (prostate cancer) cells with the IC₅₀ of 9.59 and 11.32 ug/ml, respectively .

HY-N2298

Camellianin A	Structural Classification Adinandra nitida Merr. ex Li Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Theaceae Cancer	Apoptosis
Camellianin A, the main flavonoid in A. nitida leaves, displays anticancer activity and angiotensin converting enzyme (ACE)-inhibitory activity. Camellianin A inhibits the proliferation of the human Hep G2 and MCF-7 cell lines and induces the significant increase of the G0/G1 cell population .

HY-126803

Saquayamycin B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic
Saquayamycin B (compound 3) is a new angucycline antibiotic. Saquayamycin B has antitumor activities against a human lung (H-460) and a human breast cancer cell line (MCF-7) with GI₅₀ values of 12.2 and 15.2 µM respectively .

HY-N6885

Puerarin-4'-O-β-D-glucopyranoside	Flavonoids Monophenols Classification of Application Fields Leguminosae Source classification Phenols Pueraria montana (Loureiro) Merrill Plants Disease Research Fields Isoflavones Cancer	Others
Puerarin-4'-O-β-D-glucopyranoside (compound 8) is a isoflavone from Pueraria lobata root (PLR). Puerarin-4'-O-β-D-glucopyranoside has estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-N3615

Confluentin	Structural Classification Natural Products Rhododendron simsii Planch. Source classification Plants Ericaceae	Others
Confluentin can be isolated from Rhododendron dauricum. Confluentin shows weak cytotoxicity against human tumor cells (IC₅₀: 15.05, 17.08, 18.48, and 23.01 μM for HL-60, SMMC-7712, A-549, and MCF-7) .

HY-N12299

Parthenosin Quercetin 3-O-β-D-glucuronide butyl ester	Structural Classification Flavonoids Flavones Polygonaceae Source classification Phenols Polyphenols Plants Calligonum aphyllum (Pall.) Gurke	Others
Parthenosin (Quercetin 3-O-β-D-glucuronide butyl ester) is a flavonoid, that can be isolated from the aerial parts of Calligoum polygonoides. Parthenosin shows cytotoxic activity against HepG2 and MCF-7 cell lines with IC₅₀ values of 60.46 and 61.4 μg/mL, respectively .

HY-N12607

Garcilatelic acid	Structural Classification Flavonoids Guttiferae Source classification Garcinia lateriflora Blume Plants Other Flavonoids	Others
Garcilatelic acid (Compound 5) is a compound that can be isolated from Garcinia lateriflora. Garcilatelic acid has antiproliferative activity against tumor cell lines (A549, MDA-MB-231, MCF-7, KB and KB-VIN), with IC₅₀ values of 0.5-1.3 μM .

HY-N10777

1-Ketoaethiopinone	Structural Classification Ardisia crenata Sims Terpenoids Source classification Diterpenoids Plants Myrsinaceae	Others
1-Ketoaethiopinone is an abietane-diterpenoid. 1-Ketoaethiopinone has an α, β-unsaturated carbonyl function. 1-Ketoaethiopinone shows cytotoxic activity against human cancer cell lines MOLT-4 (human lymphoblastic leukemia) and MCF-7 (human breast adenocarcinoma) .

HY-N11928

Changnanic acid	Structural Classification Kadsura heteroclita (Roxb.) Craib Ketones, Aldehydes, Acids Source classification Plants Schisandraceae	Others
Changnanic acid (schisandrin) is a triterpene compound with potential anti-tumor effects. Changnanic acid exhibits moderate cytotoxic activity against human tumor cell lines Bel-7402, MCF-7 and HL-60, with IC₅₀s of 100 μM, 100 μM and 50.51 μM respectively .

HY-N1833

3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Morus alba Linn. Cancer	Others
3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone displays cytotoxicity of 1.32, 3.92 and 5.22 μm against the human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Phenols Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-N10023

Physalin O	Structural Classification Physalis minima Linn. Cardiacglycosides Source classification Plants Solanaceae Steroids	NO Synthase
Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC₅₀ values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities .

HY-113319

β-D-Fructose	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Endogenous Metabolite
β-D-Fructose is a β-fruit sugar that can be produced by the hydrolysis of sucrose. β-D-Fructose can be used as a sweetness potentiator. β-D-Fructose can be designed as a units of antiproliferative agents against breast (MCF-7) and colon (MDST8) cancer cell lines .

HY-N9505

Schisanlactone E Kadsulactone acid	Triterpenes Structural Classification Kadsura heteroclita (Roxb.) Craib Terpenoids Source classification Plants Schisandraceae	Others
Schisanlactone E is a triterpenoids that can be isolated from Kadsura heteroclita. Schisanlactone E exhibits moderate cytotoxic activity against Bel-7402, BGC-823, MCF-7 and HL-60 cell line with IC₅₀s of 68.33, 100, >100, 73.37 μM,respectively .

HY-117872

Sartorypyrone A 20-O-Acetylsartorypyrone D	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Fungal
Sartorypyrone A (20-O-Acetylsartorypyrone D) is a monocyclic terpenoid isolated from the soil fungus Neosartorya fischeri. Sartorypyrone A exhibits in vitro growth inhibitory activity against MCF-7, NCI-H460, and A375-C5 cell lines, and has potential anticancer properties.

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Apocynaceae Structural Classification Cardiacglycosides Source classification Plants Steroids	Others
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

HY-138098

Sartorypyrone B	Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields Cancer	Others
Sartorypyrone B is a 2β-acetoxyl analogue of chevalone C. Sartorypyrone B is yielded from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213). Sartorypyrone B exhibits strong growth inhibitory activity, having GI₅₀s of 17.8, 20.5, and 25.0 μM, respectively, for MCF-7, NCI-H460, and A375-C5. Sartorypyrone B has the potential for the research of breast adenocarcinoma, non-small cell lung cancer, and melanoma diseases .

HY-W080443

O-allylvanillin	Classification of Application Fields Disease Research Fields Cancer	Others
O-allylvanillin is O-allylchalcone derivative with anti-cancer effects . O-allylvanillin inhibits THP-1, HL60, Hep-G2, MCF-7 cells growth with IC₅₀ values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectively .

HY-126618

Aspochalasin I	Structural Classification Natural Products Source classification Ericameria laricifolia (A.Gray) Shinners Plants Compositae	Tyrosinase
Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC₅₀s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC₅₀ of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent .

HY-Y0598

trans-Chalcone	Structural Classification Flavonoids Aronia melanocarpa Rosaceae Plants	Fatty Acid Synthase (FASN) Apoptosis Fungal
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity .

HY-N13162

Hemsleyadin D	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Hemsleya pengxianensis W. J. Chang	Others
Hemsleyadin D is a triterpenoid compound derived from Hemsleya penxianensis with antitumor activity. Its IC₅₀ values against K562, MGC-803, U118, HepG2, A549, and MCF-7 cells are 93.9, 47.1, 25.9, 56.1, 66.3, and 67.6 μM, respectively .

Cat. No.	Product Name	Chemical Structure

HY-13636S

Fulvestrant-d3
Fulvestrant-d₃ is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].

HY-50936S

Trabectedin-d3

Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

HY-13762S

Tesmilifene-d4
Tesmilifene-d4 is the deuterium labeled Tesmilifene (HY-13762). Tesmilifene is an antihistamine agent and a chemical sensitizer. Tesmilifene targets cytochrome P450, exhibits hormonal effects on DNA synthesis in MCF-7 cells, and stimulates the tumor growth in mouse/rat models. Tesmilifene overcomes multidrug resistance .

HY-13502AS

Mitoxantrone-d8 dihydrochloride

Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

Cat. No.	Product Name		Classification

HY-111640

3'-Azido-3'-deoxy-5-methylcytidine		Azide
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC₅₀ of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC₅₀ of 0.06 μM in peripheral blood mononuclear (PBM) cells . 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-160062

S2.2 aptamer sodium		Aptamers
S2.2 aptamer sodium is a nucleic acid aptamer targeting the mucin MUC1 and can be used for targeted imaging of MCF-7 cancer cells. S2.2 aptamer sodium was labeled with Cy5, and when fluorescent silicon nanodots (SiND) were present, the fluorescence was quenched; when MUC1 was also present, the fluorescence was restored. S2.2 aptamer sodium detects MUC1 with a linear range of 3.33-250 nM .

HY-147081

AS 1411 AGRO-100		Aptamers
AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .

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