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Results for "

cluster of differentiation 47 (CD47)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CD3 (1) CD47 (23) FLT3 (2) Nuclear Factor of activated T Cells (NFAT) (1) 5 alpha Reductase (1) 5-HT Receptor (6) AAK1 (1) ADAMTS (1) ADC Antibody (1) ADC Cytotoxin (1) ADC Linker (1) Adrenergic Receptor (1) Akt (2) Androgen Receptor (1) Antibiotic (5) Antibody-Drug Conjugates (ADCs) (1) Antifolate (1) Apoptosis (25) Autophagy (1) Bacterial (10) Bcl-2 Family (2) Bcr-Abl (4) BCRP (1) Biochemical Assay Reagents (26) Btk (2) Caspase (4) Cathepsin (1) CCR (1) CD19 (1) CD28 (1) CD73 (1) CDK (6) CGRP Receptor (2) Cholinesterase (ChE) (6) COX (1) Cuproptosis (1) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (2) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Metabolite (8) Drug-Linker Conjugates for ADC (2) EGFR (5) Endogenous Metabolite (26) Epigenetic Reader Domain (1) ERK (2) FAAH (1) Ferroptosis (3) Flavivirus (3) Fluorescent Dye (10) Fungal (5) G-quadruplex (1) GABA Receptor (2) GCGR (1) Glucosidase (1) Glutathione Peroxidase (1) GPR55 (2) GSK-3 (1) HBV (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (3) Histamine Receptor (1) Histone Demethylase (1) Histone Methyltransferase (4) HIV (6) HIV Protease (2) HSP (3) IAP (1) IKK (2) Influenza Virus (1) Interleukin Related (7) Isotope-Labeled Compounds (11) JAK (1) JNK (2) Kallikrein (2) Keap1-Nrf2 (1) Kinesin (1) Liposome (4) Lipoxygenase (1) LPL Receptor (2) mAChR (1) MDM-2/p53 (1) MEK (1) Microtubule/Tubulin (2) MMP (2) Monoamine Oxidase (3) mTOR (2) NAMPT (2) Necroptosis (1) Neurokinin Receptor (4) NF-κB (5) NO Synthase (1) NOD-like Receptor (NLR) (1) OAT (1) p38 MAPK (3) PAK (1) Parasite (6) PARP (1) PD-1/PD-L1 (3) Phosphatase (2) Phosphodiesterase (PDE) (1) Phospholipase (1) Potassium Channel (1) PPAR (1) Prostaglandin Receptor (2) PROTACs (5) PTEN (1) Ras (1) Reactive Oxygen Species (6) Renin (1) RET (1) RGS Protein (1) ROCK (1) ROR (2) ROS Kinase (1) SARS-CoV (2) Ser/Thr Protease (3) Serotonin Transporter (1) Sigma Receptor (1) Small Interfering RNA (siRNA) (1) Smo (1) Sodium Channel (1) STAT (2) STING (6) Tau Protein (1) TGF-beta/Smad (2) TGF-β Receptor (5) Thyroid Hormone Receptor (2) TNF Receptor (7) Topoisomerase (1) TROP2 (1) TRP Channel (2) Tryptophan Hydroxylase (1) Tyrosinase (3) VD/VDR (8) Virus Protease (1) Wnt (1)
By Research Areas:	Cancer (146) Cardiovascular Disease (14) Endocrinology (11) Infection (48) Inflammation/Immunology (59) Metabolic Disease (35) Neurological Disease (52)
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Targets Recommended: CD47 CD3 CD6 CD2 Neprilysin FLT3 Anaplastic lymphoma kinase (ALK) P-glycoprotein Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990131

*Anti-Mouse CD47/IAP Antibody (MIAP301)*	CD47	Others
Anti-Mouse CD47/IAP Antibody (MIAP301) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse CD47/IAP.

HY-P99172

CC-90002	CD47 Interleukin Related	Cancer
CC-90002 is a *humanized anti-CD47* monoclonal antibody (mAb)*. CC-90002 has a high affinity for binding to CD47* with a subnanomolar K_d value. CC-90002 can be used for the research of hematologic malignancies and solid tumors .

HY-P990132

*Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410)*	CD47	Others
Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse/rat/human CD47/IAP.

HY-P99533

Urabrelimab SRF-231; SRF231	CD47 Interleukin Related	Cancer
Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction .

HY-143224B

NCGC00138783 TFA	CD47	Cancer
NCGC00138783 TFA is a selective inhibitor targeting CD47/SIRPα axis, with an IC₅₀ of 50 μM. NCGC00138783 TFA directly blocks the interaction between CD47 and SIRPα axis .

HY-115983

DMUP	CD47 Apoptosis	Cancer
DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity .

HY-RS02250

CD47 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CD47	Others
CD47 Human Pre-designed siRNA Set A contains three designed siRNAs for CD47 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD47 Human Pre-designed siRNA Set A CD47 Human Pre-designed siRNA Set A

HY-143224

NCGC00138783	CD47	Cancer
NCGC00138783 is a selective inhibitor targeting CD47/SIRPα axis, with an IC₅₀ of 50 µM. NCGC00138783 directly blocks the interaction between CD47 and SIRPα axis .

HY-143224A

NCGC00138783 free base	CD47	Cancer
NCGC00138783 free base is a selective inhibitor targeting CD47/SIRPα axis, with an IC₅₀ of 50 µM. NCGC00138783 free base directly blocks the interaction between CD47 and SIRPα axis .

HY-P10420

RS17	CD47 Interleukin Related	Cancer
RS17 is an anti-tumor peptide designed to bind specifically to the *CD47* molecule and block the interaction between *CD47* and its ligand, SIRPα, on the surface membrane of macrophages. The main regulatory mechanism of RS17 is to prevent *CD47* from transmitting selective phagocytosis signals to SIRPα by binding to *CD47*, so that macrophages do not recognize tumor cells as their own tissue, but phagocytose them as foreign substances, thereby inhibiting immune escape of tumor cells. RS17 can be used to study the mechanism of anti-tumor response and immune escape .

HY-P99777

Ontorpacept TTI-621	CD47	Cancer
Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a *CD47-blocking* checkpoint inhibitor with antitumor activity .

HY-143225

NCGC00538431	CD47	Others
NCGC00538431 is a potent modulator of SIRPα-CD47 .

HY-P3968

Thrombospondin-1 (1016-1021) (human, bovine, mouse)	CD47	Others
Thrombospondin-1 (1016-1021) (human, bovine, mouse), a Thrombospondin-1-derived peptide, is a truncated peptide devoid of CD47-binding activity .

HY-P990694

Zeripatamig TG-1801	CD19 CD47	Inflammation/Immunology
Zeripatamig is an anti-CD19/CD47 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99029

Magrolimab 1 Publications Verification Hu5F9-G4	CD47	Cancer
Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab can block the "don't eat me" signal of *CD47*, thereby promoting macrophage mediated phagocytosis. Magrolimab has antitumor activity in malignant bone tumors and breast cancer .

HY-P99026

Lemzoparlimab TJ011133; TJC4	CD47	Cancer
Lemzoparlimab (TJ011133; TJC4) is a humanized anti-CD47 IgG4 antibody. Lemzoparlimab has a strong anti-tumor activity .

HY-P0144

Thrombospondin-1 (1016-1023) (human, bovine, mouse)	CD47 Apoptosis	Inflammation/Immunology
Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a *CD47* agonist peptide .

HY-P99706

Ligufalimab AK 117	CD47 Interleukin Related	Cancer
Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity .

HY-151132

Glutaminyl cyclases-IN-1 IsoQC-IN-1	CD47	Cancer
Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC₅₀ values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages .

HY-P10388

TAX2 peptide	CD47 TGF-β Receptor	Cancer
TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment .

HY-P99175

KWAR 23	CD47	Cancer
KWAR23 is an anti-human SIRPα antibody. KWAR23 binds human SIRPα with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research .

HY-P3970

KRFK	TGF-β Receptor	Inflammation/Immunology
KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach .

HY-P3970A

KRFK TFA 2 Publications Verification	TGF-β Receptor	Inflammation/Immunology
KRFK TFA, a peptide derived from TSP-1, can activate TGF-β. KRFK TFA promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach .

HY-120284

CCCI-01	Others	Cancer
CCCI-01 is a centrosome clustering inhibitor. CCCI-01 has selective effects on cancer. CCCI-01 can be used for the research of non-cross-resistant anti-cancer agents with blocking centrosome clustering .

HY-116681

Aflavarin	Others	Infection
Aflavarin is produced from cluster 39 expressed mainly in sclerotia. Aflavarin exhibits anti-insectan activity .

HY-P990033

Anzurstobart CC-95251; BMS-986351	CD47	Cancer
Anzurstobart (CC-95251; BMS-986351) is a high-affinity, fully human monoclonal anti-SIRPα antibody that blocks the binding of CD47 to SIRPα. Anzurstobart enhances macrophage phagocytic activity against DLBCL cell lines in co-culture models when combined with the antibody Rituximab (HY-P9913). Anzurstobart has the potential for solid and hematologic malignancies research .

HY-16438

RRx-001 10+ Cited Publications	CD47 Apoptosis Parasite	Infection Inflammation/Immunology Cancer
RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity . RRx-001 is a dual small molecule checkpoint inhibitor by downregulating *CD47* and SIRP-α . RRx-001 is a potent inhibitor of G6PD and shows potent antimalarial activity .

HY-P99021

Galcanezumab LY 2951742	CGRP Receptor	Neurological Disease
Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research .

HY-156533A

5-HT2 agonist-1 free base	5-HT Receptor	Neurological Disease Inflammation/Immunology Cancer
5-HT2 agonist-1 (Compound 24) free base is a 5-HT2A & 5-HT2B & 5-HT2C agonist, with IC₅₀s of 10 nM, 8.3, and 1.6 nM respectively. 5-HT2 agonist-1 free base can be used for research of depression, alcoholism, tobacco and cocaine addiction, inflammation, cluster headache, PTSD, seizure disorders and other CNS disorders .

HY-156533

5-HT2 agonist-1	5-HT Receptor	Cancer
5-HT2 agonist-1 (Compound 24) is a 5-HT2A & 5-HT2B & 5-HT2C agonist, with IC₅₀s of 10 nM, 8.3, and 1.6 nM respectively. 5-HT2 agonist-1 free base can be used for research of depression, alcoholism, tobacco and cocaine addiction, inflammation, cluster headache, PTSD, seizure disorders and other CNS disorders .

HY-12797

GF 15	Others	Cancer
GF 15 is a potent inhibitor of centrosomal clustering in tumor cells.

HY-156534

5-HT2A&5-HT2C agonist-1	5-HT Receptor	Neurological Disease Inflammation/Immunology Cancer
5-HT2A&5-HT2C agonist-1 (Example 2) is a 5-HT2A & 5-HT2C agonist, with IC₅₀s of 196 nM and 0.9 nM respectively. 5-HT2A&5-HT2C agonist-1 can be used for research of depression, alcoholism, tobacco and cocaine addiction, inflammation, cluster headache, PTSD, seizure disorders and other CNS disorders .

HY-P5984

Thioether-cyclized helix B peptide, CHBP	mTOR	Others
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-P5984A

Thioether-cyclized helix B peptide, CHBP TFA	mTOR	Others
Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-131967

CD73-IN-4	CD73	Inflammation/Immunology Cancer
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC₅₀ of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology .

HY-12040

Elesclomol 40+ Cited Publications STA-4783	Reactive Oxygen Species Apoptosis Cuproptosis	Cancer
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

HY-P10106

TAT-PAK18 inhibitory peptide	PAK	Cancer
TAT-PAK18 inhibitory peptide is a membrane-permeable PAK inhibitory peptide. TAT-PAK18 inhibitory peptide reduces F-actin clusters and occludes the effect of Shank3 knockdown .

HY-12518

OF-1 3 Publications Verification	Epigenetic Reader Domain	Cancer
OF-1 is a potent pan-BRPF bromodomain (BRD) inhibitor, with IC₅₀ values of 270 nM, 1.2 μM for TRIM24 and BRPF1B, respectively .

HY-I0726

Enantiomer of Sofosbuvir	Others	Infection
Enantiomer of Sofosbuvir is an enantiomer of Sofosbuvir, a prescription medicine for the treatment of patients with chronic hepatitis C. There is no biological activity report on enantiomer of Sofosbuvir until now.

HY-145795

OF-02	Liposome	Others
OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.

HY-121034

Acaterin	Others	Others
Acaterin is a compound isolated from Pseudomonas. Its biosynthetic gene cluster has been identified, and related studies have proposed its biosynthetic pathway. Comparative transcriptomics has shown that its formation is related to the bacterial regulatory network.

HY-146146

Kolavenic acid analog KAA	Kinesin	Cancer
Kolavenic acid analog (KAA) is an anticancer agent. Kolavenic acid analog shows strong activity against HSET-overproducing yeast cells. Kolavenic acid analog inhibits centrosome clustering in human cancer cells containing high HSET levels and supernumerary centrosomes .

HY-W250128

Dodecenylsuccinic anhydride (mixture of isomers) DDSA (mixture of isomers)	Biochemical Assay Reagents	Others
2-Dodecen-1-Ylsuccinic Anhydride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Dodecenylsuccinic anhydride (mixture of isomers) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-18377

Bioymifi DR5 Activator	TNF Receptor Apoptosis	Cancer
Bioymifi (DR5 Activator), a potent TRAIL receptor DR5 activator, binds to the extracellular domain (ECD) of DR5 with a K_d of 1.2 μM. Bioymifi can act as a single agent to induce DR5 clustering and aggregation, leading to apoptosis .

HY-76937

Impurity of Doxercalciferol	VD/VDR	Endocrinology
Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.

HY-134782

OF-Deg-Lin	Liposome	Others
OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).

HY-118090

L-γ-Glutamyl-L-glutamic acid	Others	Others
L-γ-Glutamyl-L-glutamic acid is the isomer of D-γ-Glutamyl-D-glutamic acid (HY-118090A), and can be used as an experimental control. D-γ-Glutamyl-D-glutamic acid is a poly(γ-glutamic acid) of clusters of D- and D-glutamic acid repeating units in a linear chain .

HY-149035

PAA4	Others	Cancer
PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model .

HY-149036

PAA5	Ferroptosis Endogenous Metabolite Reactive Oxygen Species	Cancer
PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity .

HY-15265

Impurity F of Calcipotriol	VD/VDR	Cancer
Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P99533

Urabrelimab SRF-231; SRF231	Classification of Application Fields Disease Research Fields Cancer	CD47 Interleukin Related
Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction .

HY-P99777

Ontorpacept TTI-621	Classification of Application Fields Disease Research Fields Cancer	CD47
Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a *CD47-blocking* checkpoint inhibitor with antitumor activity .

HY-P99029

Magrolimab 1 Publications Verification Hu5F9-G4	Classification of Application Fields Disease Research Fields Cancer	CD47
Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab can block the "don't eat me" signal of *CD47*, thereby promoting macrophage mediated phagocytosis. Magrolimab has antitumor activity in malignant bone tumors and breast cancer .

HY-P99026

Lemzoparlimab TJ011133; TJC4	Classification of Application Fields Disease Research Fields Cancer	CD47
Lemzoparlimab (TJ011133; TJC4) is a humanized anti-CD47 IgG4 antibody. Lemzoparlimab has a strong anti-tumor activity .

HY-P990033

Anzurstobart CC-95251; BMS-986351	Classification of Application Fields Disease Research Fields Cancer	CD47
Anzurstobart (CC-95251; BMS-986351) is a high-affinity, fully human monoclonal anti-SIRPα antibody that blocks the binding of CD47 to SIRPα. Anzurstobart enhances macrophage phagocytic activity against DLBCL cell lines in co-culture models when combined with the antibody Rituximab (HY-P9913). Anzurstobart has the potential for solid and hematologic malignancies research .

HY-17409

Nystatin Maximum Cited Publications 25 Publications Verification	Infection Structural Classification Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Mammalian Cell Culture Disease Research Disease Research Fields	Fungal Antibiotic Apoptosis Bacterial
Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

HY-W018772

D-Ribose(mixture of isomers) 3 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Cancer	Endogenous Metabolite
D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-116681

Aflavarin	Structural Classification Microorganisms Source classification Coumarins Phenylpropanoids	Others
Aflavarin is produced from cluster 39 expressed mainly in sclerotia. Aflavarin exhibits anti-insectan activity .

HY-121034

Acaterin	Structural Classification Natural Products Microorganisms Source classification	Others
Acaterin is a compound isolated from Pseudomonas. Its biosynthetic gene cluster has been identified, and related studies have proposed its biosynthetic pathway. Comparative transcriptomics has shown that its formation is related to the bacterial regulatory network.

HY-149036

PAA5	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Ferroptosis Endogenous Metabolite Reactive Oxygen Species
PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity .

HY-N6013

Aloin(mixture of A&B)	Infection Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields	MMP Bacterial Fungal
Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases (MMPs) .

HY-131152

Leucinostatin (mixture of A&B)	Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Inflammation/Immunology Disease Research Fields Other Antibiotics	Antibiotic
Leucinostatin (mixture of A&B), the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus, are antibiotics .

HY-W018772R

D-Ribose(mixture of isomers) (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Saccharides	Endogenous Metabolite
D-Ribose(mixture of isomers) (Standard) is the analytical standard of D-Ribose(mixture of isomers). This product is intended for research and analytical applications. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-N12498

Aureonuclemycin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Aureonuclemycin can be isolated from Staphylococcus aureus to obtain its biosynthetic gene cluster. Aureonuclemycin exists in two forms: Type A and Type B. Aureonuclemycin A is a nucleoside antibiotic that is structurally similar to herbicides and contains adenine. Aureonuclemycin B contains 5′-deoxyadenosine and exhibits antibacterial activity. Aureonuclemycin can be used in the research of bacterial leaf blight in rice, citrus canker, and bacterial leaf spot in rice. .

HY-17409R

Nystatin (Standard)	Structural Classification Microorganisms Antifungal Macrolide Antibiotics Antibiotics Source classification Mammalian Cell Culture Disease Research	Fungal Antibiotic Apoptosis Bacterial
Nystatin (Standard) is the analytical standard of Nystatin. This product is intended for research and analytical applications. Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

HY-W355141

Isopulegol	Structural Classification Natural Products Classification of Application Fields Source classification Essence, Fragrance Myrtaceae Cosmetic Research Plants Disease Research Fields Cancer Eucalyptus citriodora Hook. f.	Others
Isopulegol is one of the main components of ECO (Eucalyptus citriodora oil). ECO has antibacterial activity .

HY-116757

(±)-α-CMBHC	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(±)-α-CMBHC is a metabolite of α-Tocopherol .

HY-Y0344I

Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al Halite, meets analytical specification of Ph. Eur. BP USP	Classification of Application Fields Disease Research Fields Cancer	Biochemical Assay Reagents
Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt, is a biochemical reagent that can be used for life science related research.

HY-139637

(±)-Silybin Silibinin (mixture of Silybin A and Silybin B)	Structural Classification Flavanonols Flavonoids Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Others
(±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity .

HY-P99431

KY-1044 Alomfilimab; SAR 445256	Classification of Application Fields Disease Research Fields Cancer	Others
KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOS ^high cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8 ⁺ T_Eff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response .

HY-B1341

Norethynodrel Enidrel; SC 4642; NSC 15432	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
Norethynodrel (Enidre) is a 19-nortestosterone derivative to be used as a progestagen. Norethynodrel can be used for researching inhibition of ovulation . Norethynodrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N1651

2,3',4,6-Tetrahydroxybenzophenone	Structural Classification Gentiana lutea L. Source classification Gentianaceae Phenols Polyphenols Plants	Others
2,3',4,6-Tetrahydroxybenzophenone, a kind of benzophenone, is the immediate precursor of xanthones in higher plants .

HY-N8549A

5-Dihydrocortisone	Structural Classification Classification of Application Fields Cardiacglycosides Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
5-Dihydrocortisone is a 5-Dihydrocortisone with mixture of isomers. 5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver

HY-P99605

Cinrebafusp alfa PRS 343	Classification of Application Fields Disease Research Fields Cancer	EGFR TNF Receptor
Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (K_d=0.3 nM) and human monomeric CD137 (4-1BB; K_d=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research .

HY-N0244

Theaflavin-3'-gallate 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	Apoptosis Necroptosis
Theaflavin-3'-gallate is a monomer of theaflavins found in black tea, which has anti-UVB damage activity and inhibits cell apoptosis and necroptosis. Theaflavin-3'-gallate acts as a pro-oxidant and induces oxidative stress in cancer cells, inhibiting xanthine oxidase (OX), with an IC₅₀ of 7.6 μM .

HY-N9686

Caffeoyl-CoA	Natural Products Gramineae Source classification Secale cereale Plants	Others
Caffeoyl-CoAcould be isolated from leaf tissues of Gramineae with a K_m value of 1.45 μM .

HY-N3905

Fragransin A2 (+)-Fragransin A2	Structural Classification Knema tenuinervia W. J. de Wilde Source classification Phenols Polyphenols Myristicaceae Plants	Others
Fragransin A2 is a lignan that can be isolated from the stems of Knema furfuracea (Myristicaceae). Fragransin A2 shows anticancer activity .

HY-N9075

9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one	Structural Classification Monophenols Source classification Phenols Musaceae Plants Musa basjoo Sieb. et Zucc.	Glucosidase
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC₅₀: 3.86 mg/L) .

HY-122416

6,8-Diprenylnaringenin Lonchocarpol A; Senegalensin	Structural Classification Classification of Application Fields Erythrinasenegalensis DC. Source classification Metabolic Disease Plants Moraceae Flavonoids Leguminosae Humulus lupulus L. Flavonones Phenols Polyphenols Disease Research Fields Cancer	BCRP
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and ³H-Methotrexate transport (IC₅₀=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin .

HY-113403

Pyridinoline	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Pyridinoline, a fluorescent material, is a bone resorption biomarker. Pyridinoline also is a type crosslink of collagen .

HY-Y1787

Dimethyl malonate	Structural Classification Natural Products Melia azedarach L. Plants Meliaceae	Apoptosis
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .

HY-113434B

5-HETE (±)-5-HETE	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
5-HETE ((±)-5-HETE), a fatty acid, is a oxidative derivative of Arachidonic acid. 5-HETE is a mixture of 5(S)-HETE and 5(R)-HETE. 5-HETE is a potent aggregating agent that induces the aggregation of neutrophils with an IC₅₀ value of 200 nM .

HY-B1890

(±)-Catechin 1 Publications Verification rel-Cianidanol; rel-Catechuic acid	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Camellia sinensis (L.) O. Ktze. Infection Phenols Polyphenols Inflammation/Immunology Disease Research Fields Theaceae	COX
(±)-Catechin (rel-Cianidanol) This is a green tea polyester. Catechin possesses anti-cancer activity, which has led to its demise. (±)-Catechin 具有两种forms (+)-Catechin and its reflection body (-)-Catechin. (+)-Catechin inhibitory environment-1 (COX-1) IC₅₀ 为 1.4 μM. (-)-Catechin has the effect of promoting hBM-MSC adipose cell differentiation, increasing adipose tissue, and PPARγ horizontal. (±)-Catechin has anti-diabetic, anti-hypertrophic, anti-diabetic, anti-cardiovascular, anti-infective, and liver-protecting effects.

HY-117586

9-PAHPA	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
9-PAHPA is a fatty acid esters of hydroxy fatty acid (FAHFA). FAHFAs are a new family of endogenous lipids, have antidiabetic and anti-inflammatory effects .

HY-N4107

Phyllanthin	Phyllanthus urinaria Linn. Structural Classification Classification of Application Fields Source classification Lignans Metabolic Disease Euphorbiaceae Phenylpropanoids Plants Disease Research Fields	TGF-beta/Smad
Phyllanthin is an effective oral anticancer agent. Phyllanthin inhibits MOLT-4 cell viability, increases apoptosis, inhibits cell migration and invasion. Phyllanthin exerts anti-fibrotic effects by down-regulating TGF signaling pathway via ALK5 and Smad2/3. Phyllanthin also has anti-inflammatory and antibacterial properties .

HY-N4107R

Phyllanthin (Standard)	Phyllanthus urinaria Linn. Structural Classification Source classification Lignans Euphorbiaceae Phenylpropanoids Plants	TGF-beta/Smad
Phyllanthin (Standard) is the analytical standard of Phyllanthin. This product is intended for research and analytical applications. Phyllanthin is an effective oral anticancer agent. Phyllanthin inhibits MOLT-4 cell viability, increases apoptosis, inhibits cell migration and invasion. Phyllanthin exerts anti-fibrotic effects by down-regulating TGF signaling pathway via ALK5 and Smad2/3. Phyllanthin also has anti-inflammatory and antibacterial properties .

HY-N0750

Monocrotaline 20+ Cited Publications Crotaline	Structural Classification Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Crotalaria pallida Ait. Plants Disease Research Fields Cancer	Others
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC₅₀s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. ^[2][6][8].

HY-W013935

Bisphenol B	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite
Bisphenol B is a very close structural analog of Bisphenol A (HY-18260), an endocrine disrupting chemical (EDC) and a substance of very high concern (SVHC) in the European Union (EU) for both human health. Bisphenol B shows endocrine disruptive properties or other adverse effects on animal models .

HY-N8394

Eupatolide	Source classification Plants Compositae Guilandina minax (Hance) G. P. Lewis	Others
Eupatolide is an antitumor agent that can be isolated from Eupatorium formosanum. Eupatolide has cytotoxic activity and inhibits human epidermoid carcinoma of larynx cell growth in vitro .

HY-N12239

Condurango glycoside E	Apocynaceae Marsdenia cundurango Rchb.f. Source classification Plants	Others
Condurango glycoside E is a glycoside compound that can be isolated from the bark extract of Marsdenia cundurango .

HY-W013935R

Bisphenol B (Standard)	Structural Classification Source classification Phenols Polyphenols Endogenous metabolite	Endogenous Metabolite
Bisphenol B (Standard) is the analytical standard of Bisphenol B. This product is intended for research and analytical applications. Bisphenol B is a very close structural analog of Bisphenol A (HY-18260), an endocrine disrupting chemical (EDC) and a substance of very high concern (SVHC) in the European Union (EU) for both human health. Bisphenol B shows endocrine disruptive properties or other adverse effects on animal models .

HY-P99849

Depatuxizumab ABT-806	Classification of Application Fields Disease Research Fields Cancer	EGFR
Depatuxizumab is a brain-penetrant and humanized tumor-specific anti EGFR monoclonal antibody. Depatuxizumab inhibits the growth of xenograft models of mutant EGFRvIII and wild-type EGFR. Depatuxizumab can be used for research on cancer .

HY-113410

3-Methylglutaric acid	Structural Classification Classification of Application Fields Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH) .

HY-P99208

Lirilumab 2 Publications Verification IPH2102	Classification of Application Fields Disease Research Fields Cancer	Others
Lirilumab (IPH2102) is an anti-KIR monoclonal antibody, and shows antitumor activity. Lirilumab can be used in Leukemia, squamous cell carcinoma of the head and neck (SCCHN) research .

HY-W017423

(-)-Carvone	Structural Classification Microorganisms Ketones, Aldehydes, Acids Gymnaster koraiensis Source classification Umbelliferae Plants	Cholinesterase (ChE)
(-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-W017423R

(-)-Carvone (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Gymnaster koraiensis Source classification Umbelliferae Plants	Cholinesterase (ChE)
(-)-Carvone (Standard) is the analytical standard of (-)-Carvone. This product is intended for research and analytical applications. (-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae .

HY-128850

N-Acetyl-D-mannosamine N-Acetylmannosamine; ManNAc	Structural Classification Natural Products Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders .

HY-P99045

Sacituzumab	Classification of Application Fields Disease Research Fields Cancer	ADC Antibody TROP2
Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab is used for the synthesis of antibody-drug conjugates (ADC) drugs. Antibody-drug conjugates with sacituzumab (sacituzumab govitecan) (HY-132254) targeting TROP-2 have been approved for the field of triple-negative breast cancer .

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Monophenols Classification of Application Fields Neurological Disease Cassia obtusifolia L. Source classification Phenols Metabolic Disease Caesalpiniaceae Plants Disease Research Fields	Phosphatase
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression .

HY-N3002

α-Arbutin 4-Hydroxyphenyl α-D-glucopyranoside	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Cosmetic Research Ericaceae Plants Disease Research Fields	Tyrosinase
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a tyrosinase inhibitor, which is used as an effective skin whiteners. α-Arbutin is promising for research of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes .

Cat. No.	Product Name	Chemical Structure

HY-132382S

β-Sitosterol-d7 (mixture of diasteromers)
β-Sitosterol-d₇ (Mixture of Diastereomers) is the deuterium labeled β-Sitosterol (mixture of diasteromers)[1].

HY-W018772S15

D-Ribose(mixture of isomers)-13C5

D-Ribose(mixture of isomers)- ¹³C₅ isomers)- ¹³C₅ is the ¹³C labeled D-Ribose(mixture of isomers)[1]. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner[1].

HY-132485S

N-Methyl Pantoprazole-d3 (Mixture of 1 and 3 isomers)
N-Methyl Pantoprazole-d3 (Mixture of 1 and 3 isomers) is the deuterium labeled N-Methyl Pantoprazole (Mixture of 1 and 3 isomers) .

HY-132676S

Ramiprilat-d5 (Mixture of Diastereomers)
Ramiprilat-d₅ (Mixture of Diastereomers) is the deuterium labeled Ramiprilat (Mixture of Diastereomers)[1].

HY-W653769

Deltamethrin-d5 (Mixture of Diastereomers)
Deltamethrin-d5 (Mixture of Diastereomers) is the deuterium labeled Deltamethrin (Mixture of Diastereomers) .

HY-151002S

M8 metabolite of Carvedilol-d5
M8 metabolite of Carvedilol-d₅ is the deuterium labeled M8 metabolite of Carvedilol[1].

HY-132706S

N-Deformyl Formoterol-d6 Fumarate (Mixture of Diastereomers)
N-Deformyl Formoterol-d₆ Fumarate (Mixture of Diastereomers) is the deuterium labeled N-Deformyl Formoterol Fumarate (Mixture of Diastereomers)[1].

HY-132637S

Chlorfenvinphos-d10(Mixture of cis-trans isomers)
Chlorfenvinphos-d₁₀(Mixture of cis-trans isomers) is the deuterium labeled Chlorfenvinphos (Mixture of cis-trans isomers)[1].

HY-132379S

Hydroxy Pioglitazone-d5 (M-IV) (Mixture of-diastereomers)
Hydroxy Pioglitazone-d₅ (M-IV) (Mixture of-diastereomers) is the deuterium labeled Hydroxy Pioglitazone (M-IV) (Mixture of-diastereomers)[1].

HY-134670S

α-Hydroxy Metoprolol-d5 (Mixture of Diastereomers)
α-Hydroxy Metoprolol-d₅ (Mixture of Diastereomers) is the deuterium labeled α-Hydroxy Metoprolol Mixture of Diastereomers[1].

HY-12650S

Mirogabalin-13C2,d1 (Mixture of Diastereomers)
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS .

HY-113026S

(2RS,4R,8R)-δ-Tocopherol-d4 (Mixture of Diastereomers)
(2RS,4R,8R)-δ-Tocopherol-d₄ (Mixture of Diastereomers) is the deuterium labeled (2RS,4R,8R)-δ-Tocopherol (Mixture of Diastereomers)[1].

HY-150857S

Thymine-α,α,α,6-d4 Glycol (mixture of diastereomers)-d4
Thymine-α,α,α,6-d₄ Glycol (mixture of diastereomers)-d₄ is the deuterium labeled Thymine-α,α,α,6-d4 Glycol (mixture of diastereomers)[1].

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